Patent | Date |
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Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers Grant 10,844,375 - Uhlmann , et al. November 24, 2 | 2020-11-24 |
Multimeric oligonucleotide compounds Grant 10,704,046 - Uhlmann , et al. | 2020-07-07 |
Modified TGF-beta oligonucleotides Grant 10,538,768 - Jaschinski , et al. Ja | 2020-01-21 |
Modified Tgf-beta Oligonucleotide For Use In A Method Of Preventing And/or Treating An Ophthalmic Disease App 20190144865 - JASCHINSKI; Frank ;   et al. | 2019-05-16 |
CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity Grant 10,260,071 - Debelak , et al. | 2019-04-16 |
Multimeric Oligonucleotide Compounds App 20190062743 - Uhlmann; Eugen ;   et al. | 2019-02-28 |
Modified TGF-beta oligonucleotide for use in a method of preventing and/or treating an ophthalmic disease Grant 10,125,368 - Jaschinski , et al. November 13, 2 | 2018-11-13 |
Multimetric oligonucleotide compounds Grant 10,093,924 - Uhlmann , et al. October 9, 2 | 2018-10-09 |
Modified Tgf-beta Oligonucleotides App 20180230473 - JASCHINSKI; Frank ;   et al. | 2018-08-16 |
Compositions And Methods For Oligonucleotide Formulations App 20180171338 - Uhlmann; Eugen ;   et al. | 2018-06-21 |
Modified Tgf-beta2 Oligonucleotides App 20180087055 - Jaschinski; Frank ;   et al. | 2018-03-29 |
Modified TGF-beta oligonucleotides Grant 9,926,563 - Jaschinski , et al. March 27, 2 | 2018-03-27 |
Multimeric Oligonucleotide Compounds Having Non-nucleotide Based Cleavable Linkers App 20180030444 - Uhlmann; Eugen ;   et al. | 2018-02-01 |
Modified TGF-beta2 oligonucleotides Grant 9,840,707 - Jaschinski , et al. December 12, 2 | 2017-12-12 |
Modified Tgf-beta Oligonucleotide For Use In A Method Of Preventing And/or Treating An Ophthalmic Disease App 20170314025 - JASCHINSKI; Frank ;   et al. | 2017-11-02 |
Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers Grant 9,790,494 - Uhlmann , et al. October 17, 2 | 2017-10-17 |
Multimeric oligonucleotides compounds having cleavable linkers Grant 9,732,340 - Uhlmann , et al. August 15, 2 | 2017-08-15 |
Methods of delivering multiple targeting oligonucleotides to a cell using cleavable linkers Grant 9,732,341 - Uhlmann , et al. August 15, 2 | 2017-08-15 |
Multimeric Oligonucleotide Compounds App 20170211065 - Uhlmann; Eugen ;   et al. | 2017-07-27 |
Modified TGF-beta oligonucleotide for use in a method of preventing and/or treating an ophthalmic disease Grant 9,688,988 - Jaschinski , et al. June 27, 2 | 2017-06-27 |
Multimeric oligonucleotides compounds Grant 9,580,708 - Uhlmann , et al. February 28, 2 | 2017-02-28 |
Inhibitory Oligonucleotides And Their Use In Therapy App 20160355822 - Uhlmann; Eugen ;   et al. | 2016-12-08 |
CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity App 20160348115 - Debelak; Harald ;   et al. | 2016-12-01 |
CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity Grant 9,382,545 - Debelak , et al. July 5, 2 | 2016-07-05 |
Modified Tgf-beta Oligonucleotides App 20160076037 - JASCHINSKI; Frank ;   et al. | 2016-03-17 |
Modified Tgf-beta2 Oligonucleotides App 20160060632 - JASCHINSKI; Frank ;   et al. | 2016-03-03 |
Modified Tgf-beta Oligonucleotide For Use In A Method Of Preventing And/or Treating An Ophthalmic Disease App 20160040167 - JASCHINSKI; Frank ;   et al. | 2016-02-11 |
Inhibitory Oligonucleotides And Their Use In Therapy App 20150344884 - UHLMANN; Eugen ;   et al. | 2015-12-03 |
Phosphate-modified oligonucleotide analogs with enhanced immunostimulatory activity Grant 9,200,287 - Uhlmann , et al. December 1, 2 | 2015-12-01 |
Immune stimulatory oligonucleotide analogs containing modified sugar moieties Grant 9,186,399 - Uhlmann , et al. November 17, 2 | 2015-11-17 |
Multimeric Oligonucleotide Compounds Having Non-nucleotide Based Cleavable Linkers App 20150315585 - Uhlmann; Eugen ;   et al. | 2015-11-05 |
Multimeric Oligonucleotides Compounds Having Cleavable Linkers App 20150315587 - Uhlmann; Eugen ;   et al. | 2015-11-05 |
Methods Of Delivering Multiple Targeting Oligonucleotides To A Cell Using Non-nucleotide Based Cleavable Linkers App 20150315586 - Uhlmann; Eugen ;   et al. | 2015-11-05 |
Methods Of Delivering Multiple Targeting Oligonucleotides To A Cell Using Cleavable Linkers App 20150315588 - Uhlmann; Eugen ;   et al. | 2015-11-05 |
Multimeric Oligonucleotides Compounds App 20150299695 - Uhlmann; Eugen ;   et al. | 2015-10-22 |
Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties Grant 9,156,875 - Debelak , et al. October 13, 2 | 2015-10-13 |
Multimeric Oligonucleotide Compounds App 20150247141 - Uhlmann; Eugen ;   et al. | 2015-09-03 |
Synthetic double-stranded oligonucleotides for specific inhibition of gene expression Grant 8,772,469 - Uhlmann , et al. July 8, 2 | 2014-07-08 |
CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity App 20140163213 - Debelak; Harald ;   et al. | 2014-06-12 |
CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity Grant 8,580,268 - Debelak , et al. November 12, 2 | 2013-11-12 |
Immune Stimulatory Oligoribonucleotide Analogs Containing Modified Oligophosphate Moieties App 20130164333 - DEBELAK; Harald ;   et al. | 2013-06-27 |
Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties Grant 8,349,812 - Debelak , et al. January 8, 2 | 2013-01-08 |
Immunostimulatory nucleic acids Grant 8,304,396 - Krieg , et al. November 6, 2 | 2012-11-06 |
Immunostimulatory nucleic acids Grant 8,283,328 - Krieg , et al. October 9, 2 | 2012-10-09 |
Polymide nucleic acid derivatives, and agents and processes for preparing them Grant 8,268,560 - Uhlmann , et al. September 18, 2 | 2012-09-18 |
Combination Motif Immune Stimulatory Oligonucleotides With Improved Activity App 20120219571 - VOLLMER; JORG ;   et al. | 2012-08-30 |
Combination motif immune stimulatory oligonucleotides with improved activity Grant 8,198,251 - Vollmer , et al. June 12, 2 | 2012-06-12 |
C-class oligonucleotide analogs with enhanced immunostimulatory potency Grant 8,188,254 - Uhlmann , et al. May 29, 2 | 2012-05-29 |
Modified Oligoribonucleotide Analogs With Enhanced Immunostimulatory Activity App 20110244025 - Uhlmann; Eugen ;   et al. | 2011-10-06 |
Semi-soft C-class Immunostimulatory Oligonucleotides App 20110201672 - Krieg; Arthur M. ;   et al. | 2011-08-18 |
5' CpG nucleic acids and methods of use Grant 7,956,043 - Krieg , et al. June 7, 2 | 2011-06-07 |
Polymide Nucleic Acid Derivatives, And Agents And Processes For Preparing Them App 20110117569 - UHLMANN; Eugen ;   et al. | 2011-05-19 |
Immune Stimulatory Oligonucleotide Analogs Containing Modified Sugar Moieties App 20110098456 - Uhlmann; Eugen ;   et al. | 2011-04-28 |
Polyamide nucleic acid derivatives and agents, and processes for preparing them Grant 7,897,346 - Uhlmann , et al. March 1, 2 | 2011-03-01 |
Oligonucleotides which inhibit expression of the OB-RGRP protein Grant 7,884,084 - Jockers , et al. February 8, 2 | 2011-02-08 |
Class A Oligonucleotides with Immunostimulatory Potency App 20100285041 - Uhlmann; Eugen ;   et al. | 2010-11-11 |
Immune Stimulatory Oligoribonucleotide Analogs Containing Modified Oligophosphate Moieties App 20100260788 - Debelak; Harald ;   et al. | 2010-10-14 |
Phosphate-Modified Oligonucleotide Analogs with Enhanced Immunostimulatory Activity App 20100261779 - Uhlmann; Eugen ;   et al. | 2010-10-14 |
Semi-soft c-class immunostimulatory oligonucleotides Grant 7,795,235 - Krieg , et al. September 14, 2 | 2010-09-14 |
Compositions of TLR ligands and antivirals App 20100189772 - Vollmer; Jorg ;   et al. | 2010-07-29 |
Nucleic Acid-lipophilic Conjugates App 20100183639 - Uhlmann; Eugen ;   et al. | 2010-07-22 |
CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity App 20100166780 - Debelak; Harald ;   et al. | 2010-07-01 |
Oligoribonucleotides and uses thereof App 20100144846 - Jurk; Marion ;   et al. | 2010-06-10 |
Polyamide Nucleic Acid Derivatives And Agents, And Processes For Preparing Them App 20100022016 - UHLMANN; Eugen ;   et al. | 2010-01-28 |
Oligoribonucleotide derivatives for specific inhibition of gene expression Grant 7,635,769 - Uhlmann , et al. December 22, 2 | 2009-12-22 |
Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification App 20090306177 - Uhlmann; Eugen ;   et al. | 2009-12-10 |
Nucleic acid-lipophilic conjugates Grant 7,615,539 - Uhlmann , et al. November 10, 2 | 2009-11-10 |
Semi-soft C-class immunostimulatory oligonucleotides Grant 7,566,703 - Krieg , et al. July 28, 2 | 2009-07-28 |
Polyamide nucleic acid derivatives and agents, and processes for preparing them Grant 7,550,582 - Uhlmann , et al. June 23, 2 | 2009-06-23 |
Semi-soft C-class Immunostimulatory Oligonucleotides App 20090137519 - Krieg; Arthur M. ;   et al. | 2009-05-28 |
Combination Motif Immune Stimulatory Oligonucleotides With Improved Activity App 20090087446 - VOLLMER; JORG ;   et al. | 2009-04-02 |
Polyamide-oligonucleotide derivatives, their preparation and use Grant 7,485,421 - Uhlmann , et al. February 3, 2 | 2009-02-03 |
Abasic Oligonucleotide as Carrier Platform for Antigen and Immunostimulatory Agonist and Antagonist App 20080113929 - Lipford; Grayson B. ;   et al. | 2008-05-15 |
Polyamide Nucleic Acid Derivatives And Agents, And Processes For Preparing Them App 20080070258 - UHLMANN; Eugen ;   et al. | 2008-03-20 |
Conjugates And Processes For Their Preparation And Their Use For Transporting Molecules Across Biological Membranes App 20080071069 - Uhlmann; Eugen ;   et al. | 2008-03-20 |
Compositions and methods for oligonucleotide formulations App 20080045473 - Uhlmann; Eugen ;   et al. | 2008-02-21 |
Immunostimulatory nucleic acids App 20070224210 - Krieg; Arthur M. ;   et al. | 2007-09-27 |
Polyamide nucleic acid derivatives, and agents, and processes for preparing them Grant 7,241,882 - Uhlmann , et al. July 10, 2 | 2007-07-10 |
G cap-stabilized oligonucleotides Grant 7,229,974 - Peyman , et al. June 12, 2 | 2007-06-12 |
Modified oligoribonucleotide analogs with enhanced immunostimulatory activity App 20060241076 - Uhlmann; Eugen ;   et al. | 2006-10-26 |
Semi-soft C-class immunostimulatory oligonucleotides App 20060140875 - Krieg; Arthur M. ;   et al. | 2006-06-29 |
Novel oligoribonucleotide derivatives for specific inhibition of gene expression App 20060025374 - Uhlmann; Eugen ;   et al. | 2006-02-02 |
Sequence requirements for inhibitory oligonucleotides App 20050239733 - Jurk, Marion ;   et al. | 2005-10-27 |
C-class oligonucleotide analogs with enhanced immunostimulatory potency App 20050239734 - Uhlmann, Eugen ;   et al. | 2005-10-27 |
Polyamide-oligonucleotide derivatives, their preparation and use Grant 6,919,441 - Uhlmann , et al. July 19, 2 | 2005-07-19 |
Antisense oligonucleotides against tenascin for the treating of vitiligo App 20050148017 - Peyman, Anuschirwan ;   et al. | 2005-07-07 |
Nucleic acid-lipophilic conjugates App 20050130911 - Uhlmann, Eugen ;   et al. | 2005-06-16 |
Polyamide nucleic acid derivatives, and agents and processes for preparing them Grant 6,905,820 - Uhlmann , et al. June 14, 2 | 2005-06-14 |
Antisense oligonucleotides against tenascin for treating vitiligo Grant 6,878,547 - Peyman , et al. April 12, 2 | 2005-04-12 |
Mini-proinsulin, its preparation and use Grant 6,875,589 - Dorschug , et al. April 5, 2 | 2005-04-05 |
Immunostimulatory nucleic acids App 20050059619 - Krieg, Arthur M. ;   et al. | 2005-03-17 |
Polyamide-oligonucleotide derivatives, their preparation and use App 20050026817 - Uhlmann, Eugen ;   et al. | 2005-02-03 |
Modified antisense nucleotides complementary to a section of the human haras gene App 20050020523 - Uhlmann, Eugen ;   et al. | 2005-01-27 |
Oligonucleotides which inhibit expression of the OB-RGRP protein and method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor App 20050009042 - Jockers, Ralf ;   et al. | 2005-01-13 |
Polyamide nucleic acid derivatives, and agents, and processes for preparing them App 20050009073 - Uhlmann, Eugen ;   et al. | 2005-01-13 |
Polyamide nucleic acid derivatives, and agents, and processes for preparing them App 20040265885 - Uhlmann, Eugen ;   et al. | 2004-12-30 |
5' CpG nucleic acids and methods of use App 20040171571 - Krieg, Arthur M. ;   et al. | 2004-09-02 |
Polyamide nucleic acid derivatives and agents and processes for preparing them Grant 6,777,544 - Uhlmann , et al. August 17, 2 | 2004-08-17 |
Modified antisense nucleotides complementary to a section of the human Ha-ras gene Grant 6,723,706 - Uhlmann , et al. April 20, 2 | 2004-04-20 |
Polyamide-oligonucleotide derivatives, their preparation and use App 20030203359 - Uhlmann, Eugen ;   et al. | 2003-10-30 |
Antisense oligonucleotides for the inhibition of integrin alphav -subunit expression App 20030176384 - Uhlmann, Eugen ;   et al. | 2003-09-18 |
Synthetic double-stranded oligonucleotides for specific inhibition of gene expression App 20030139585 - Uhlmann, Eugen ;   et al. | 2003-07-24 |
Oligoribonucleotide derivatives for specific inhibition of gene expression App 20030105052 - Uhlmann, Eugen ;   et al. | 2003-06-05 |
Modified Antisense Nucleotides Complementary To A Section Of The Human Ha-ras Gene App 20030064514 - UHLMANN, EUGEN ;   et al. | 2003-04-03 |
Polyamide nucleic acid derivatives and agents and processes for preparing them App 20030022172 - Uhlmann, Eugen ;   et al. | 2003-01-30 |
Polyamide nucleic acid derivatives, and agents and processes for preparing them App 20020187473 - Uhlmann, Eugen ;   et al. | 2002-12-12 |
Oligonucleotides for the inhibition of human eg5 expression Grant 6,472,521 - Uhlmann , et al. October 29, 2 | 2002-10-29 |
G cap-stabilized oligonucleotides App 20020151512 - Peyman, Anuschirwan ;   et al. | 2002-10-17 |
Stabilized oligonucleotides and their use Grant 6,348,312 - Peyman , et al. February 19, 2 | 2002-02-19 |
3 modified oligonucleotide derivatives Grant 6,326,487 - Peyman , et al. December 4, 2 | 2001-12-04 |
Short Oligonucleotides For The Inhibition Of Vegf Expression App 20010021772 - UHLMANN, EUGEN ;   et al. | 2001-09-13 |
Phosphonomonoester nucleic acids process for their preparation and their use Grant 6,127,346 - Peyman , et al. October 3, 2 | 2000-10-03 |
G cap-stabilized oligonucleotides Grant 6,121,434 - Peyman , et al. September 19, 2 | 2000-09-19 |
Process for amplifying nucleic acids using DNA/PNA primers Grant 6,063,571 - Uhlmann , et al. May 16, 2 | 2000-05-16 |
Gene and gene structure coding for an aminotransferase, and microorganisms which express this gene Grant 6,051,408 - Bartsch , et al. April 18, 2 | 2000-04-18 |
PNA synthesis using an amino protecting group which is labile to weak acids Grant 6,046,306 - Breipohl , et al. April 4, 2 | 2000-04-04 |
Enzymatic RNA molecules that cleave mutant N-RAS Grant 6,037,463 - Uhlmann , et al. March 14, 2 | 2000-03-14 |
Oligonucleotide analogs, their preparation and use Grant 6,033,909 - Uhlmann , et al. March 7, 2 | 2000-03-07 |
G cap-stabilized oligonucleotides Grant 6,013,639 - Peyman , et al. January 11, 2 | 2000-01-11 |
Phosphonomonoester nucleic acids, process for their preparation, and their use Grant 5,874,553 - Peyman , et al. February 23, 1 | 1999-02-23 |
Homogeneous gene probe test using a receptor directed against the label Grant 5,858,668 - Neuenhofer , et al. January 12, 1 | 1999-01-12 |
Process for preparing substituted N-ethyglycine derivatives Grant 5,817,811 - Breipohl , et al. October 6, 1 | 1998-10-06 |
3'-modified oligonucleotide derivatives Grant 5,696,248 - Peyman , et al. December 9, 1 | 1997-12-09 |
3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use Grant 5,646,261 - Uhlmann , et al. July 8, 1 | 1997-07-08 |
Antisense oligonucleotides against HSV 1, and their preparation Grant 5,563,050 - Peyman , et al. October 8, 1 | 1996-10-08 |
Method of preparing fusion proteins Grant 5,358,857 - Stengelin , et al. * October 25, 1 | 1994-10-25 |
Phosphinothricin-resistance gene, and its use Grant 5,276,268 - Strauch , et al. January 4, 1 | 1994-01-04 |
Fusion proteins, their preparation and use Grant 5,227,293 - Stengelin , et al. July 13, 1 | 1993-07-13 |
Process for 5'-phosphorylation of nucleic acids Grant 5,039,796 - Engels , et al. August 13, 1 | 1991-08-13 |
Preparation of polypeptides having human .gamma.-interferon activity Grant 4,832,959 - Engels , et al. May 23, 1 | 1989-05-23 |