U.S. patent number 3,924,641 [Application Number 05/498,740] was granted by the patent office on 1975-12-09 for bi-phasic current stimulation system.
This patent grant is currently assigned to Axotronics Inc.. Invention is credited to Gerhard T. Weiss.
United States Patent |
3,924,641 |
Weiss |
December 9, 1975 |
Bi-phasic current stimulation system
Abstract
A circuit for producing current-controlled bi-phasic pulses to
stimulate living tissue includes two conducting paths connected in
parallel between high and low voltage terminals, with each of the
conducting paths having first and second switches connected in
series therein. The intersections of the respective first and
second switches in each of the paths define output terminals across
which bi-phasic pulses are produced. These output terminals include
electrode members for electrically attaching them to living
tissues. Interconnecting circuits connect the first switch of each
of the conducting paths with the second switch of the other
conducting path to respectively open and close the second switches
in response to the first switches of opposite paths being opened
and closed. A digital programmer alternately drives one of the
first switches open and the other closed. Current controlling
valves are connected in the paths between the low voltage terminal
and the output terminals to selectively control current flow
through the electrodes.
Inventors: |
Weiss; Gerhard T. (Northford,
CT) |
Assignee: |
Axotronics Inc. (Hamden,
CT)
|
Family
ID: |
23982312 |
Appl.
No.: |
05/498,740 |
Filed: |
August 19, 1974 |
Current U.S.
Class: |
607/74; 607/45;
607/46; 607/40; 607/42; 607/9 |
Current CPC
Class: |
A61N
1/36025 (20130101); A61N 1/36021 (20130101) |
Current International
Class: |
A61N
1/36 (20060101); A61N 001/36 () |
Field of
Search: |
;128/420,421,422,423,419B,419C,419E,419G,419PG,419R |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: Cohen; Lee S.
Attorney, Agent or Firm: Spruegel; Walter
Claims
The embodiment of the invention in which an exclusive property or
privilege are claimed are defined as follows:
1. A bi-phasic pulse generator for producing pulses to stimulate
living tissue comprising:
first and second voltage terminals having voltages of different
magnitudes;
first and second conducting paths connected in parallel between
said first and second voltage terminals, each of said first and
second conducting paths including first and second switches
connected in series, with said first switch being connected
electrically closer to said first voltage terminal than said second
switch and the intersections of said first and second switches in
each of said paths defining output electrodes across which
pulse-generator output bi-phasic pulses are produced;
interconnecting means for connecting said first switch of said
first conducting path with said second switch of said second
conducting path and said first switch of said second conducting
path with said second switch of said first conducting path to
respectively close and open said second switches in response to
said first switches of opposite paths being opened and closed;
and,
a driving means for alternately driving one of said first switches
open and the other closed for a first predetermined time period,
and vice versa for a second predetermined time period.
2. A bi-phasic pulse generator as in claim 1 wherein is further
included current-control, valve means connected in each of said
paths between said first voltage terminal and said output
electrodes to thereby control the flow of current through said
electrodes.
3. A bi-phasic pulse generator as in claim 2, wherein said switches
and control means comprise transistors.
4. A bi-phasic pulse generator as claimed in claim 1, wherein said
driving means comprises a programming circuit means for alternately
driving said first switches in a programmed sequence.
5. A bi-phasic pulse generator as claimed in claim 1, wherein said
output electrodes include means for electrically attaching said
electrodes to living tissue.
6. A bi-phasic pulse generator for producing pulses to stimulate
living tissue comprising:
first and second voltage terminals having different voltage
potentials thereon;
first and second output electrodes adapted to be attached to living
tissue;
a control circuit means connected between each of said first and
second voltage terminals and to each of said output electrodes for
alternately connecting said first voltage terminal to said first
electrode and said second voltage terminal to said second electrode
and said first voltage terminal to said second electrode and said
second voltage terminal to said first electrode, said control
circuit means connected between said first voltage terminal and
each of said electrodes including electronic valve means for
selectively controlling the magnitude of current flow between said
first voltage terminal and both of said first and second
electrodes; and
a control means attached to said electronic valve means for
selectively adjusting the flow of current through said valve
means.
7. A bi-phasic pulse generator as claimed in claim 6 wherein said
electronic valve means comprise transistors.
Description
BACKGROUND OF THE INVENTION
This invention relates broadly to the art of electronic stimulators
and more particularly to devices for generating current controlled,
bi-phasic pulses to stimulate areas of the brain, nerves, or other
organs.
In behavioral research, stimulation of certain areas of the brain
is often used to find ways to suppress intractable pain, aggressive
behavior, or to explore brain structures and their influence on the
behavior of animals or humans. Brain stimulation is also applied in
efforts to fight other disorders associated with the brain.
In addition to brain research, electrical stimulation is also
widely used to restore proper functioning of various organs such as
hearts, lungs, or bladders in cases where the control of these
organs is disturbed because of disease, injury, or other
causes.
The effects elicited by electrical stimulations are, to a large
extent, determined by the amounts of current flow rather than by
the magnitudes of applied voltages. Since the impedance between
points of stimulation varies widely and may even change during
stimulation, the current will also change even if the voltage is
maintained at a constant level. This makes it difficult to control
the amount of current flow. Thus, it is an object of this invention
to provide an electrical stimulation circuit which provides an
adjustable, controllable, stimulating current.
Further, if pulses of one polarity only are used for stimulation,
electro/chemical effects tend to create unfavorable interactions
between electrodes and tissues. Many researchers, therefore, prefer
stimulation pulses in both polarities, such as with a negative
pulse, followed immediately by a positive pulse, preferably each
being of equal magnitude and duration. Thus, it is an object of
this invention to provide an electrical circuit for providing such
pulses.
Another object of this invention is to provide a circuit for
generating bi-phasic, current-controlled pulses with current
amplitudes of both negative and positive portions thereof being
proportional to an applied control voltage.
Still another object of this invention is to provide a current
controlled, bi-phasic or mono-phasic pulse generator whose output
impedance is high enough to allow the use of its stimulation
electrodes for measuring the response to stimulation, e.g. brain
stimulation, EEG recordings and the like.
Still another object of this invention is to provide a circuit for
generating bi-phasic or mono-phasic current controlled pulses, the
characteristics of which are controlled by a programmer.
SUMMARY OF THE INVENTION
According to principles of this invention, two parallel paths
connected between two voltage terminals each have first and second
series-connected switches therein with the switch intersections
thereof defining output terminals across which pulse-generator
output bi-phasic, current controlled, pulses are produced. The
first switch of the first path is interconnected to the second
switch of the second path, and vice versa, to assure that the first
and second switches of opposite paths are opened and closed
together. A driving device alternately drives the first switch of
the first path "on" or "closed," and the first switch of the second
path "off," or "open," and vice versa. The driving mechanism
measures the time period that the switches are in open and closed
positions. Electronic valves are located in each of the first and
second paths between the first voltage terminal and the output
terminals to selectively control current flow to the
electrodes.
BRIEF DESCRIPTION OF THE DRAWINGS
The foregoing and other objects, features and advantages of the
invention will be apparent from the following more particular
description of a preferred embodiment of the invention, as
illustrated in the accompanying drawings in which reference
characters refer to the same parts throughout the different views.
The drawings are not necessarily to scale, emphasis instead being
placed upon illustrating principles of the invention in a clear
manner.
FIG. 1 is a schematic diagram of a current controlled, bi-phasis
pulse generator employing principles of this invention; and
FIG. 2 is a diagrammatic representation of an output pulse of the
bi-phasic pulse generator of FIG. 1.
DESCRIPTION OF THE PREFERRED EMBODIMENT
The preferred embodiment of the pulse generator of this invention,
illustrated in FIG. 1, comprises two first transistor switches 10
and 12, two second transistor switches 14 and 16, a pair of current
control valve devices 18 and 20, a digital programmer 22 and a
control voltage generator 24. The pulse generator is energized by a
+20 volts, positive voltage terminal 26 and a -20 volts, negative
voltage terminal 28 and forms two parallel connected, main
conducting paths 30 and 32 between these voltage terminals. In
practice, a single 40 volt source could be used.
The first transistor switches 10 and 12 comprise PNP transistors Q1
and Q2 and 22K control resistors 34 and 36. The second transistor
switches 14 and 16 comprise NPN transistors Q3 and Q4 and 100K
control resistors 38 and 40. In this regard, the interconnection
between the positive voltage terminal 26 and the base of the
transistor Q1 via the resistor 34 holds transistor Q1 in an off
state when transistor Q4 is off and no current can flow through
resistor 40. When transistor Q4 is on, a current path is
established from the positive voltage terminal 26 through both the
Q1 base-to-emitter junction, and the resistor 34, the resistor 40,
and the transistor Q4 to the negative voltage terminal 28, thereby
placing transistor Q1 in an on state. There is a similar
interaction between the resistors 36 and 38 and the transistors Q2
and Q3.
The first and second current control valve devices 18 and 20
respectively comprise NPN transistors Q5 and Q6 and series
resistors 42 and 44.
In the preferred embodiment, the switching transistors Q1, Q2, Q3,
and Q4 are chosen to operate, for practical purposes, in an on-off
fashion while the current control transistors Q5 and Q6 are chosen
to operate in a gradual manner for regulating current flow.
Electrodes 46 and 48, which are adapted to be electrically attached
to living tissue, are respectively electrically connected to the
main conducting paths 30 and 32 between the transistor switch 10
and the first current control valve device 18 and between the
transistor switch 12 and the second current control valve device
20.
The digital programmer 22 is connected to the bases of the
switching transistors Q3 and Q4 and selectively provides gating
signals to these transistors. The digital programmer 22 also drives
the control voltage generator 24 which, in turn, selectively
produces steady-state control voltages at the bases of the first
and second current control transistors Q5 and Q6.
Diodes 50 and 52 prevent excess reverse voltages from occurring
between the bases and emitters of the current control transistors
Q5 and Q6.
In operation, the electrodes 46 and 48 are connected to living
tissue, such as nerves or other organs, either directly or
indirectly. When it is desired to transmit biphasic pulses to the
living tissue, the digital programmer 22 gates the switching
transistor Q3 on and the switching transistor Q4 off for a time
period of T1 and then gates the switching transistor Q4 on and
switching transistor Q3 off for an identical time period T2.
During time period T1, when the switching transistor Q3 is on, a
current flow is established through the control resistors 36 and 38
to lower the potential appearing at the base of the switching
transistor Q2. This places the switching transistor Q2 in an on
mode of operation. Thus, a circuit is established between the
positive voltage terminal 26 and the first electrode 46 through the
switching transistor Q2. A circuit is also completed between the
second electrode 48 and the negative voltage terminal 28 via the
current control transistor Q5, the resistor 42, and diode 50, and
the switching transistor Q3. Thus, a circuit is completed from the
positive voltage terminal 26 to the negative voltage terminal 28
via living tissue connected to the electrodes 46 and 48. It should
be noted that during time period T, both of the switching
transistors Q4 and Q1 are locked in off modes.
During the time period T2 the switching transistor Q3 is turned off
so that the voltage appearing at the base of the switching
transistor Q2 rises to the voltage of the positive voltage terminal
26, which, in turn, turns off the switching transistor Q2. Thus,
the electrode 46 is no longer connected to the high voltage
terminal 26. However, the switching transistor Q4 is turned on by
the digital programmer 22 so that the voltage at the base of the
switching transistor Q1 rises to turn on this transistor. Thus, the
electrode 48 is now in communication with the positive voltage
terminal 26. Also, the other electrode 46 is now in communication
with the negative voltage terminal 28 via the second current
control device 20, the diode 52 and the switching transistor Q4.
Thus, the polarities, and current flow, of the electrodes 46 and 48
have been reversed.
Before and after the time periods T1 and T2, the digital programmer
does not place either the third or fourth switching transistors Q3
and Q4 in on modes of operation so that neither of the electrodes
46 and 48 are connected to the positive and negative voltage
terminals 26 and 28. The output signal appearing at electrodes 46
and 48 before, after, and during the time periods T1 and T2 can be
graphically represented as shown in FIG. 2.
In the preferred embodiment, the control voltage generator 24
provides steady-state control voltages ranging from 1.4 to 5 volts.
It should be understood that the magnitude of a selected control
voltage determines the magnitudes of current signals applied by the
electrodes 46 and 48 to living tissue.
It should be further appreciated that the duration of the pulses
can be accurately controlled by the digital programmer 22.
In addition, during periods of no pulses, since all four transistor
switches are open, the electrodes 46 and 48 can be used for
recording purposes.
While the invention has been particularly shown and described with
reference to a preferred embodiment, it will be understood by those
skilled in the art that various changes in form and detail may be
made therein without departing from the spirit and scope of the
invention. For example, various voltage magnitudes at voltage
terminals 26 and 28 could be employed and it is not necessary that
one of the supply voltages be either negative or positive. With
regard to voltage magnitude, the high voltage source limit is
determined by the perimeters of the transistors chosen and/or by
the maximum current which has to be driven through the highest
expected load impedance. Further, the transistors could be replaced
by other types of electrical valves.
* * * * *