U.S. patent number 3,870,046 [Application Number 05/462,805] was granted by the patent office on 1975-03-11 for insufflator.
This patent grant is currently assigned to Miles Laboratories, Inc.. Invention is credited to Roderick Douglas Elliott.
United States Patent |
3,870,046 |
Elliott |
March 11, 1975 |
**Please see images for:
( Certificate of Correction ) ** |
INSUFFLATOR
Abstract
This invention relates to an inhalation device for dispensing
medicament in finely divided form for use in enabling a patient to
inhale therefrom a dispersion of particulate material released from
a capsule.
Inventors: |
Elliott; Roderick Douglas
(Burnham, EN) |
Assignee: |
Miles Laboratories, Inc.
(Elkhart, IN)
|
Family
ID: |
10172161 |
Appl.
No.: |
05/462,805 |
Filed: |
April 22, 1974 |
Foreign Application Priority Data
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|
|
|
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May 8, 1973 [GB] |
|
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21991/73 |
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Current U.S.
Class: |
128/203.15 |
Current CPC
Class: |
A61M
15/0028 (20130101); A61M 15/0033 (20140204); A61M
15/0098 (20140204); A61M 2202/064 (20130101) |
Current International
Class: |
A61M
15/00 (20060101); A61m 013/00 () |
Field of
Search: |
;128/266,208,206,272
;222/193,81,85 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Medbery; Aldrich F.
Claims
What is claimed is:
1. An inhalation device comprising a housing having a first chamber
portion and a medicament chamber portion therewithin and having a
single mouthpiece formed with passage means communicating
respectively with said chamber portions; said housing being
provided with an air exhaust port communicating with said first
chamber portion and an air inlet port communicating with said
medicament chamber portion; a rotor mounted within said housing; a
drive portion on said rotor driven by said air flow through said
first chamber portion; means for dispersing a medicament within
said medicament chamber portion; and air flow control valve means
for causing air flow through said first chamber portion and said
exhaust port by exhalation through said mouthpiece to effect rotor
movement and for causing air flow through said inlet port and said
medicament chamber portion to effect entrainment of said medicament
by inhalation through said mouthpiece.
2. A device according to claim 1 wherein said dispersing means is
carried by said rotor within said medicament chamber.
3. A device according to claim 1 wherein said dispersing means
comprises means on said rotor for mounting at least one capsule of
medicament.
4. A device according to claim 1 wherein said dispersing means
comprises means on said rotor for mounting a plurality of capsules
of medicament in spaced relation about the axis of said rotor.
5. Apparatus according to claim 3 wherein said dispersing means
comprises a replaceable unitary multiple capsule pack mounted on
said rotor.
6. Apparatus according to claim 3 wherein a plurality of capsules
of medicament are mounted on said rotor and form therewith a
replaceable unit.
7. A device according to claim 3 wherein means is provided for
opening a capsule carried by said housing.
8. A device according to claim 7 wherein the capsule opening means
comprises a plunger manually movable between a rest position and an
operative position in which it is adapted to penetrate a capsule
carried by said rotor.
9. A device according to claim 8 wherein said plunger is spring
biased toward its rest position.
10. Apparatus according to claim 1 wherein the drive portion on
said rotor comprises a plurality of vanes in said first chamber
portion.
11. Apparatus according to claim 1 wherein said valve means
comprises a first non return valve controlling air flow through
said exhaust port and a second non return valve controlling air
flow through said inlet port.
12. Apparatus according to claim 11 wherein said non return valves
are normally closed flap valves.
13. Apparatus according to claim 1 wherein said passage means
comprises separate first and second passages communicating
respectively with said first and medicament chamber portions.
14. Apparatus according to claim 13 wherein said first passage is
positioned to direct exhaled air at the drive portion of said rotor
in a manner tending to cause rotation thereof.
Description
SUMMARY OF THE INVENTION
Various insufflators have been proposed and used from which
medicament can be inhaled directly into the lungs of a patient.
These prior devices have generally relied upon the motion of the
air being inhaled causing dispersion of the medicament into the air
being inhaled. Typical of such insufflators are devices described
by Altounyan et al., in U.S. Pat. Nos. 3,507,277 (1970); 3,635,219
(1972); and 3,669,113 (1972).
It has now been found that more reliable operation of an
insufflator can be obtained where the patient can use the action of
exhalation to distribute or disperse the medicament powder within a
medicament chamber ready for reliable treatment upon inhalation
drawing the dispersed powder from the chamber into the lungs of the
patient.
According to the present invention there is provided an inhaling
device for dispensing medicament in finely divided form comprising
a housing, a rotor adapted to disperse a medicament in a chamber
within the housing, a mouthpiece communicating with the chamber, a
passage communicating between the chamber and the exterior of the
housing, a drive portion of the rotor adapted to be driven by flow
of air therepast, a second passage communicating the mouthpiece
with the drive portion of the rotor, and valve means permitting
flow of air from the mouthpiece past said drive portion upon
exhalation into the mouthpiece and alternatively permitting air
flow through said first mentioned passage and said chamber upon
inhalation through the mouthpiece.
Preferably the drive portion is provided in a second chamber within
the housing with the two chambers being separated by the rotor
which may conveniently be in the form of a disk. The drive portion
of the rotor can then comprise a plurality of vanes adapted to be
driven by an exhaled flow of air from the mouthpiece through the
second chamber.
While the device may be constructed so as to provide on the rotor
mounting means for a single capsule, preferably so located as to
extend radially outwards from the axis of the rotor so that when
the outer end thereof is opened or pierced spinning of the rotor
will help to distribute medicament centrifugally within the
medicament chamber, in an alternative arrangement a plurality of
capsules may be mounted in a ring around the axis of the rotor with
these capsules being usable in turn as required by the patient.
With this latter arrangement conveniently the plurality of capsules
may be mounted as part of a blister pack which is secured to a face
of the rotor. It will be apparent that both capsule mounting
arrangements provide means for effectively dispersing medicament
within the medicament chamber upon spinning of the rotor.
While it is possible for the capsules to be individually opened or
pierced as required by the patient before use by opening of the
housing it is preferred that capsule opening means are provided
selectively operable for breaking or piercing a capsule carrier by
the rotor. A convenient form of capsule opening means may comprise
a plunger manually movable between a rest position and the capsule
opening position, the plunger being spring biased to a rest
position. If a portion of the rotor is engageable from the outside
of the housing for permitting indexing movement of the rotor within
the housing, the rotor can readily be indexed to align a full
capsule with the capsule opening means permitting the capsules in
the insufflator to be prepared for use without any opening of the
housing by the patient being required. This is of particular
convenience when the patient may require immediate relief, as all
that he need do is take out the loaded insufflator, open a capsule
using the capsule opening means, apply the mouthpiece to his mouth
and quickly exhale before immediately inhaling to breath the
dispersed and entrained particles of medicament into his lungs.
A particularly convenient form of valve means comprises nonreturn
type flap valves covering ports through the housing, it being
possible for such flap valves to comprise simple flaps of resilient
plastic material which are normally in a position closing the ports
associated therewith.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention will be further described, by way of example, with
reference to the accompanying drawings, in which:
FIG. 1 is a front elevational view of a single dose form of
insufflator embodying the invention;
FIG. 2 is a rear elevational view of the insufflator of FIG. 1;
FIG. 3 is an end elevational view of the insufflator as viewed from
the right hand side of FIG. 1;
FIG. 4 is a fragmentary sectional view taken through the front and
cap of the insufflator and showing the inhalation nonreturn
valve;
FIG. 5 is a fragmentary sectional view taken through the rear end
cap of the insufflator and showing the exhalation nonreturn valve;
and
FIGS. 6 to 8 are views similar to FIGS. 1 to 3 but showing a
multiple dose form of the insufflator.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
Referring to the drawings, and in particular to FIGS. 1 to 3, there
is shown a single dose inhalation device comprising a substantially
cylindrical housing 1 of high impact thermosetting plastics
material provided with front and rear end caps which, in the
illustrated embodiment of the invention, are transparent. These end
caps are screwed into position so as to be removable, and at least
one of said end caps carries a bearing portion, not apparent in the
drawings, for rotatably supporting a rotor 4 within the housing.
The rotor is of disk like form and separates the chamber within the
housing into a first chamber portion at the rear thereof and a
second or medicament chamber portion at the front thereof. The
rotor 4 comprises on the front side thereof a mounting 12 for a
capsule or other suitable container 14 for accomodating a
medicament to be dispensed, and on the rear side thereof is formed
with a series of radial vanes 6 which, in a manner to be described
below, acts as a drive portion for rotating the rotor. An
inhalation passage or port 3 is provided through the end cap at the
front of the housing, while an exhalation passage or port 5 is
provided through the end cap at the rear of the housing. A
mouthpiece 2 has passage means which communicates with the interior
of the housing and may comprise a divided entry providing a passage
11' leading to the aforementioned first chamber portion within the
housing containing the vanes 6, and a passage 11 leading to the
second or medicament chamber portion within the housing within
which the rotor supports the medicament capsule 14.
Manually operable capsule opening means 7 are shown at the top of
the housing as comprising a plunger 8 which is biased by a spring 9
to the rest position where an opening projection 10 is clear from
contact with a capsule 14 carried by the rotor. The plunger 8 is
manually depressable against the action of the spring 9 to cause
the projection 10 to move towards the axis of the rotor whereby
when a capsule 14 is aligned with the projection 10 such depression
of the plunger will cause the projection 10 to break or pierce the
end of the capsule 14.
Omitted in FIGS. 1 and 2 are valve means in the form of nonreturn
inhalation and exhalation valves 13 and 15 which cooperate with the
ports 3 and 5, respectively. These are shown in cross section in
the detail views of FIGS. 4 and 5, the inhalation valve 13 being
shown at the top of FIG. 4 in the position closing the port 3 which
it adopts at rest and when a patient is exhaling through the
mouthpiece 2 while the lower part of FIG. 4 shows the position
adopted by the inhalation valve 13 when the patient is inhaling
through the mouthpiece, air being sucked into the medicament
chamber from the outside of the housing through the port 3.
Similarly FIG. 5 shows the exhalation valve 15 in its closed
position which it occupies during rest and when the patient is
inhaling through the mouthpiece and its open position which it
occupies when the patient is exhaling through the mouthpiece.
In both instances the valves are simple nonreturn flap valves which
are made of resilient plastic material biased to closed position.
The valve 13 is shown as mounted in a recess formed in an inner
surface portion of the front end cap of the housing so that it does
not project to a position where it could interfere with rotation of
the rotor, while the valve 15 is shown as mounted on the outside of
the rear end cap of the housing normally resiliently to close the
port 5.
FIGS. 6 to 8 show an alternative embodiment of insufflator which is
adapted to mount a plurality of capsules of medicament. The
structure is generally similar to that of FIGS. 1 to 3 with a
housing 21 provided with a mouthpiece 22 and having in front and
rear end caps, respectively, an inhalation port 23 and an
exhalation port 25 provided with nonreturn flap valves similar to
those illustrated in FIGS. 4 and 5. A rotor 24 provided with vanes
26 on its rear side is mounted for rotation within the housing, the
vanes being drivable by flow of air from the mouthpiece 22 through
a first chamber portion containing the vanes and out through the
exhalation port 25. On the front side of the disk like rotor a
plurality of mounting means 32 are provided for capsules or other
suitable containers 34 for accomodating a medicament to be
dispersed. The mounting means 32 are arranged to hold the capsules
extending radially from the axis of the rotor, whereby upon
rotation of the rotor a dispersion of the medicament from a capsule
will be assisted by centrifugal action, the outer end of the
capsule being the part of the capsule opened.
In this embodiment no opening means corresponding with the opening
means 7 of the first embodiment are illustrated although such may
be provided if desired. Instead, the user removes the front end cap
of the housing in order manually to open a capsule before use of
the insufflator, or he can use a piercing instrument to extend from
the mouthpiece to penetrate the end of a capsule aligned with the
mouthpiece passage 31.
As before, a portion of the rotor may be engageable exteriorly of
the housing to permit indexing of a capsule for opening.
Instead of having individual mounting means for the various
capsules they may be formed as a single blister pack which can be
attached to the front face of the rotor 24.
In an alternative arrangement the rotor and medicament filled
capsules may themselves comprise an entirely replaceable unit which
can be provided within the housing for replacement by another full
unit once all the individual doses have been used.
During use of the insufflator the patient, having loaded the device
with one or more capsules, either opens one of the capsules
manually before replacing the end cover on the housing or utilizes
an opening means 7 to open the capsule after closure of the
housing. The patient then puts the mouthpiece to his mouth and
exhales strongly therethrough, whereupon the air exhaled passes
through the passage 11' or 31 into the first chamber portion within
the housing flows past the vanes 6 or 26 and out through the
exhalation port 5 or 25, causing the rotor to spin at high speed to
disperse medicament from the opened capsule into the medicament
chamber portion within the housing. The patient then immediately
inhales strongly through the mouthpiece, whereupon the valve 15
closes and the valve 13 opens to permit air to be inhaled through
inhalation port 3 or 23 and said medicament chamber portion,
carrying with it the air entrained medicament from said chamber
portion into the lungs of the patient.
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