U.S. patent application number 12/868510 was filed with the patent office on 2011-04-21 for fusion proteins. This patent application is currently assigned to SYNTAXIN LIMITED. Invention is credited to Kei Roger Aoki, John Chaddock, Keith Foster, Joseph Francis, Philip Marks, Patrick Stancombe, Lance Steward.
Application Number | 20110091437 12/868510 |
Document ID | / |
Family ID | 36694795 |
Filed Date | 2011-04-21 |
United States Patent Application | 20110091437 |
Kind Code | A1 |
Foster; Keith ; et al. | April 21, 2011 |
A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a dynorphin Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the dynorphin Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described.
Inventors: | Foster; Keith; (Salisbury, GB) ; Chaddock; John; (Salisbury, GB) ; Marks; Philip; (Salisbury, GB) ; Stancombe; Patrick; (Salisbury, GB) ; Aoki; Kei Roger; (Irvine, CA) ; Francis; Joseph; (Irvine, CA) ; Steward; Lance; (Irvine, CA) |
Assignee: | SYNTAXIN LIMITED Abingdon CA ALLERGAN, INC. Irvine |
Family ID: | 36694795 |
Appl. No.: | 12/868510 |
Filed: | August 25, 2010 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12303078 | Sep 21, 2009 | |||
PCT/GB2007/002049 | Jun 1, 2007 | |||
12868510 | ||||
Current U.S. Class: | 424/94.3 ; 435/188; 435/320.1; 435/69.7; 536/23.2 |
Current CPC Class: | A61P 25/00 20180101; C07K 2319/055 20130101; A61K 38/4886 20130101; C12Y 304/24069 20130101; C07K 2319/06 20130101; C07K 14/665 20130101; A61K 38/00 20130101; A61K 47/6415 20170801; A61P 29/00 20180101; C12N 9/52 20130101; A61K 47/65 20170801; C12N 15/62 20130101; A61K 38/1709 20130101; A61P 25/04 20180101; A61K 38/4893 20130101; C07K 2319/50 20130101; A61K 38/482 20130101 |
Class at Publication: | 424/94.3 ; 435/188; 536/23.2; 435/320.1; 435/69.7 |
International Class: | A61K 38/48 20060101 A61K038/48; C12N 9/96 20060101 C12N009/96; C12N 15/57 20060101 C12N015/57; C12N 15/63 20060101 C12N015/63; C12P 21/02 20060101 C12P021/02; A61P 29/00 20060101 A61P029/00 |
Date | Code | Application Number |
---|---|---|
Jun 1, 2006 | GB | 0610867.4 |
Sequence CWU 1
1
9711302DNAArtificial SequenceSynthetic 1ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg ac 130221257DNAArtificial SequenceSynthetic
2ctgcagtgta tcaaggttaa caactgggat ttattcttca gcccgagtga agacaacttc
60accaacgacc tgaacaaagg tgaagaaatc acctcagata ctaacatcga agcagccgaa
120gaaaacatct cgctggacct gatccagcag tactacctga cctttaattt
cgacaacgag 180ccggaaaaca tttctatcga aaacctgagc tctgatatca
tcggccagct ggaactgatg 240ccgaacatcg aacgtttccc aaacggtaaa
aagtacgagc tggacaaata taccatgttc 300cactacctgc gcgcgcagga
atttgaacac ggcaaatccc gtatcgcact gactaactcc 360gttaacgaag
ctctgctcaa cccgtcccgt gtatacacct tcttctctag cgactacgtg
420aaaaaggtca acaaagcgac tgaagctgca atgttcttgg gttgggttga
acagcttgtt 480tatgatttta ccgacgagac gtccgaagta tctactaccg
acaaaattgc ggatatcact 540atcatcatcc cgtacatcgg tccggctctg
aacattggca acatgctgta caaagacgac 600ttcgttggcg cactgatctt
ctccggtgcg gtgatcctgc tggagttcat cccggaaatc 660gccatcccgg
tactgggcac ctttgctctg gtttcttaca ttgcaaacaa ggttctgact
720gtacaaacca tcgacaacgc gctgagcaaa cgtaacgaaa aatgggatga
agtttacaaa 780tatatcgtga ccaactggct ggctaaggtt aatactcaga
tcgacctcat ccgcaaaaaa 840atgaaagaag cactggaaaa ccaggcggaa
gctaccaagg caatcattaa ctaccagtac 900aaccagtaca ccgaggaaga
aaaaaacaac atcaacttca acatcgacga tctgtcctct 960aaactgaacg
aatccatcaa caaagctatg atcaacatca acaagttcct gaaccagtgc
1020tctgtaagct atctgatgaa ctccatgatc ccgtacggtg ttaaacgtct
ggaggacttc 1080gatgcgtctc tgaaagacgc cctgctgaaa tacatttacg
acaaccgtgg cactctgatc 1140ggtcaggttg atcgtctgaa ggacaaagtg
aacaatacct tatcgaccga catccctttt 1200cagctcagta aatatgtcga
taaccaacgc cttttgtcca ctctagacta gaagctt 125731323DNAArtificial
SequenceSynthetic 3ggatccatgc cggttaccat caacaacttc aactacaacg
acccgatcga caacaacaac 60atcattatga tggaaccgcc gttcgcacgt ggtaccggac
gttactacaa ggcttttaag 120atcaccgacc gtatctggat catcccggaa
cgttacacct tcggttacaa acctgaggac 180ttcaacaaga gtagcgggat
tttcaatcgt gacgtctgcg agtactatga tccagattat 240ctgaatacca
acgataagaa gaacatattc cttcagacta tgattaaact cttcaaccgt
300atcaaaagca aaccgctcgg tgaaaaactc ctcgaaatga ttatcaacgg
tatcccgtac 360ctcggtgacc gtcgtgtccc gcttgaagag ttcaacacca
acatcgcaag cgtcaccgtc 420aacaaactca tcagcaaccc aggtgaagtc
gaacgtaaaa aaggtatctt cgcaaacctc 480atcatcttcg gtccgggtcc
ggtcctcaac gaaaacgaaa ccatcgacat cggtatccag 540aaccacttcg
caagccgtga aggtttcggt ggtatcatgc agatgaaatt ctgcccggaa
600tacgtcagtg tcttcaacaa cgtccaggaa aacaaaggtg caagcatctt
caaccgtcgt 660ggttacttca gcgacccggc actcatcctc atgcatgaac
tcatccacgt cctccacggt 720ctctacggta tcaaagttga cgacctcccg
atcgtcccga acgagaagaa attcttcatg 780cagagcaccg acgcaatcca
ggctgaggaa ctctacacct tcggtggcca agacccaagt 840atcataaccc
cgtccaccga caaaagcatc tacgacaaag tcctccagaa cttcaggggt
900atcgtggaca gactcaacaa agtcctcgtc tgcatcagcg acccgaacat
caatatcaac 960atatacaaga acaagttcaa agacaagtac aaattcgtcg
aggacagcga aggcaaatac 1020agcatcgacg tagaaagttt cgacaagctc
tacaaaagcc tcatgttcgg tttcaccgaa 1080accaacatcg ccgagaacta
caagatcaag acaagggcaa gttacttcag cgacagcctc 1140ccgcctgtca
aaatcaagaa cctcttagac aacgagattt acacaattga agagggcttc
1200aacatcagtg acaaagacat ggagaaggaa tacagaggtc agaacaaggc
tatcaacaaa 1260caggcatacg aggagatcag caaagaacac ctcgcagtct
acaagatcca gatgtgcgtc 1320gac 132341260DNAArtificial
SequenceSynthetic 4ctgcagtgca tcgacgttga caacgaagac ctgttcttca
tcgctgacaa aaacagcttc 60agtgacgacc tgagcaaaaa cgaacgtatc gaatacaaca
cccagagcaa ctacatcgaa 120aacgacttcc cgatcaacga actgatcctg
gacaccgacc tgataagtaa aatcgaactg 180ccgagcgaaa acaccgaaag
tctgaccgac ttcaacgttg acgttccggt ttacgaaaaa 240cagccggcta
tcaagaaaat cttcaccgac gaaaacacca tcttccagta cctgtacagc
300cagaccttcc cgctggacat ccgtgacatc agtctgacca gcagtttcga
cgacgctctg 360ctgttcagca acaaagttta cagtttcttc agcatggact
acatcaaaac cgctaacaaa 420gttgttgaag cagggctgtt cgctggttgg
gttaaacaga tcgttaacga cttcgttatc 480gaagctaaca aaagcaacac
tatggacaaa atcgctgaca tcagtctgat cgttccgtac 540atcggtctgg
ctctgaacgt tggtaacgaa accgctaaag gtaactttga aaacgctttc
600gagatcgctg gtgcaagcat cctgctggag ttcatcccgg aactgctgat
cccggttgtt 660ggtgctttcc tgctggaaag ttacatcgac aacaaaaaca
agatcatcaa aaccatcgac 720aacgctctga ccaaacgtaa cgaaaaatgg
agtgatatgt acggtctgat cgttgctcag 780tggctgagca ccgtcaacac
ccagttctac accatcaaag aaggtatgta caaagctctg 840aactaccagg
ctcaggctct ggaagagatc atcaaatacc gttacaacat ctacagtgag
900aaggaaaaga gtaacatcaa catcgacttc aacgacatca acagcaaact
gaacgaaggt 960atcaaccagg ctatcgacaa catcaacaac ttcatcaacg
gttgcagtgt tagctacctg 1020atgaagaaga tgatcccgct ggctgttgaa
aaactgctgg acttcgacaa caccctgaaa 1080aagaacctgc tgaactacat
cgacgaaaac aagctgtacc tgatcggtag tgctgaatac 1140gaaaaaagta
aagtgaacaa atacctgaag accatcatgc cgttcgacct gagtatctac
1200accaacgaca ccatcctgat cgaaatgttc aacaaataca actctctaga
ctagaagctt 126051329DNAArtificial SequenceSynthetic 5ggatccgaat
tcatgccgat caccatcaac aacttcaact acagcgatcc ggtggataac 60aaaaacatcc
tgtacctgga tacccatctg aataccctgg cgaacgaacc ggaaaaagcg
120tttcgtatca ccggcaacat ttgggttatt ccggatcgtt ttagccgtaa
cagcaacccg 180aatctgaata aaccgccgcg tgttaccagc ccgaaaagcg
gttattacga tccgaactat 240ctgagcaccg atagcgataa agataccttc
ctgaaagaaa tcatcaaact gttcaaacgc 300atcaacagcc gtgaaattgg
cgaagaactg atctatcgcc tgagcaccga tattccgttt 360ccgggcaaca
acaacacccc gatcaacacc tttgatttcg atgtggattt caacagcgtt
420gatgttaaaa cccgccaggg taacaattgg gtgaaaaccg gcagcattaa
cccgagcgtg 480attattaccg gtccgcgcga aaacattatt gatccggaaa
ccagcacctt taaactgacc 540aacaacacct ttgcggcgca ggaaggtttt
ggcgcgctga gcattattag cattagcccg 600cgctttatgc tgacctatag
caacgcgacc aacgatgttg gtgaaggccg tttcagcaaa 660agcgaatttt
gcatggaccc gatcctgatc ctgatgcatg aactgaacca tgcgatgcat
720aacctgtatg gcatcgcgat tccgaacgat cagaccatta gcagcgtgac
cagcaacatc 780ttttacagcc agtacaacgt gaaactggaa tatgcggaaa
tctatgcgtt tggcggtccg 840accattgatc tgattccgaa aagcgcgcgc
aaatacttcg aagaaaaagc gctggattac 900tatcgcagca ttgcgaaacg
tctgaacagc attaccaccg cgaatccgag cagcttcaac 960aaatatatcg
gcgaatataa acagaaactg atccgcaaat atcgctttgt ggtggaaagc
1020agcggcgaag ttaccgttaa ccgcaataaa ttcgtggaac tgtacaacga
actgacccag 1080atcttcaccg aatttaacta tgcgaaaatc tataacgtgc
agaaccgtaa aatctacctg 1140agcaacgtgt ataccccggt gaccgcgaat
attctggatg ataacgtgta cgatatccag 1200aacggcttta acatcccgaa
aagcaacctg aacgttctgt ttatgggcca gaacctgagc 1260cgtaatccgg
cgctgcgtaa agtgaacccg gaaaacatgc tgtacctgtt caccaaattt
1320tgcgtcgac 132961263DNAArtificial SequenceSynthetic 6ctgcagtgtc
gtgaactgct ggtgaaaaac accgatctgc cgtttattgg cgatatcagc 60gatgtgaaaa
ccgatatctt cctgcgcaaa gatatcaacg aagaaaccga agtgatctac
120tacccggata acgtgagcgt tgatcaggtg atcctgagca aaaacaccag
cgaacatggt 180cagctggatc tgctgtatcc gagcattgat agcgaaagcg
aaattctgcc gggcgaaaac 240caggtgtttt acgataaccg tacccagaac
gtggattacc tgaacagcta ttactacctg 300gaaagccaga aactgagcga
taacgtggaa gattttacct ttacccgcag cattgaagaa 360gcgctggata
acagcgcgaa agtttacacc tattttccga ccctggcgaa caaagttaat
420gcgggtgttc agggcggtct gtttctgatg tgggcgaacg atgtggtgga
agatttcacc 480accaacatcc tgcgtaaaga taccctggat aaaatcagcg
atgttagcgc gattattccg 540tatattggtc cggcgctgaa cattagcaat
agcgtgcgtc gtggcaattt taccgaagcg 600tttgcggtta ccggtgtgac
cattctgctg gaagcgtttc cggaatttac cattccggcg 660ctgggtgcgt
ttgtgatcta tagcaaagtg caggaacgca acgaaatcat caaaaccatc
720gataactgcc tggaacagcg tattaaacgc tggaaagata gctatgaatg
gatgatgggc 780acctggctga gccgtattat cacccagttc aacaacatca
gctaccagat gtacgatagc 840ctgaactatc aggcgggtgc gattaaagcg
aaaatcgatc tggaatacaa aaaatacagc 900ggcagcgata aagaaaacat
caaaagccag gttgaaaacc tgaaaaacag cctggatgtg 960aaaattagcg
aagcgatgaa taacatcaac aaattcatcc gcgaatgcag cgtgacctac
1020ctgttcaaaa acatgctgcc gaaagtgatc gatgaactga acgaatttga
tcgcaacacc 1080aaagcgaaac tgatcaacct gatcgatagc cacaacatta
ttctggtggg cgaagtggat 1140aaactgaaag cgaaagttaa caacagcttc
cagaacacca tcccgtttaa catcttcagc 1200tataccaaca acagcctgct
gaaagatatc atcaacgaat acttcaatct agactagaag 1260ctt
12637207DNAArtificial SequenceSynthetic 7ggatccacgc acgtcgacgg
catcattacc tccaaaacta aatctctgat cgaaggtcgt 60tttggcggtt tcacgggcgc
acgcaaatca gcgcgtaaat tagctaacca ggcgctagcg 120ggcggtggcg
gtagcggcgg tggcggtagc ggcggtggcg gtagcgcact agtgctgcag
180acgcacggtc tagaatgata aaagctt 2078108DNAArtificial
SequenceSynthetic 8ggatccacgc acgtcgacgg catcattacc tccaaaacta
aatctctgat agaaggtaga 60aacaaagcgc tgaacctgca gacgcacggt ctagaatgat
aaaagctt 1089186DNAArtificial SequenceSynthetic 9catatgaata
acctcgggat tgagggtcgt tttggcggtt tcacgggcgc acgcaaatca 60gcgcgtaaat
tagctaacca gactagtggc ggtgggggta gtggcggtgg cggttcgggc
120gggggtggga gccctagggg atccgtcgac ctgcagggtc tagaagcgct
agcgtgataa 180aagctt 18610180DNAArtificial SequenceSynthetic
10ggatccacgc acgtcgacgc gattgatggt cgttttggcg gtttcacggg cgcacgcaaa
60tcagcgcgta aattagctaa ccaggcgcta gcgggcggtg gcggtagcgg cggtggcggt
120agcggcggtg gcggtagcgc actagtgctg cagacgcacg gtctagaatg
ataaaagctt 18011249DNAArtificial SequenceSynthetic 11ggatccacgc
acgtcgacgg catcattacc tccaaaacta aatctctgat cgaaggtcgt 60tacggtggtt
tcatgacctc tgaaaaatct cagaccccgc tggttaccct gttcaaaaac
120gctatcatca aaaacgctta caaaaaaggt gaagcgctag cgggtggtgg
tggttctggt 180ggtggtggtt ctggtggtgg tggttctgca ctagtgctgc
agacgcacgg tctagaatga 240taaaagctt 24912207DNAArtificial
SequenceSynthetic 12ggatccacgc acgtcgacgg catcattacc tccaaaacta
aatctctgat cgaaggtcgt 60tttggcggtt tcacgggcgc acgcaaatca gcgcgtaaac
gtaagaacca ggcgctagcg 120ggcggtggcg gtagcggcgg tggcggtagc
ggcggtggcg gtagcgcact agtgctgcag 180acgcacggtc tagaatgata aaagctt
207132709DNAArtificial SequenceSynthetic 13ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa 1320actaaatctc
tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa atcagcgcgt
1380aaattagcta accaggcgct agcgggcggt ggcggtagcg gcggtggcgg
tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtatc aaggttaaca
actgggattt attcttcagc 1500ccgagtgaag acaacttcac caacgacctg
aacaaaggtg aagaaatcac ctcagatact 1560aacatcgaag cagccgaaga
aaacatctcg ctggacctga tccagcagta ctacctgacc 1620tttaatttcg
acaacgagcc ggaaaacatt tctatcgaaa acctgagctc tgatatcatc
1680ggccagctgg aactgatgcc gaacatcgaa cgtttcccaa acggtaaaaa
gtacgagctg 1740gacaaatata ccatgttcca ctacctgcgc gcgcaggaat
ttgaacacgg caaatcccgt 1800atcgcactga ctaactccgt taacgaagct
ctgctcaacc cgtcccgtgt atacaccttc 1860ttctctagcg actacgtgaa
aaaggtcaac aaagcgactg aagctgcaat gttcttgggt 1920tgggttgaac
agcttgttta tgattttacc gacgagacgt ccgaagtatc tactaccgac
1980aaaattgcgg atatcactat catcatcccg tacatcggtc cggctctgaa
cattggcaac 2040atgctgtaca aagacgactt cgttggcgca ctgatcttct
ccggtgcggt gatcctgctg 2100gagttcatcc cggaaatcgc catcccggta
ctgggcacct ttgctctggt ttcttacatt 2160gcaaacaagg ttctgactgt
acaaaccatc gacaacgcgc tgagcaaacg taacgaaaaa 2220tgggatgaag
tttacaaata tatcgtgacc aactggctgg ctaaggttaa tactcagatc
2280gacctcatcc gcaaaaaaat gaaagaagca ctggaaaacc aggcggaagc
taccaaggca 2340atcattaact accagtacaa ccagtacacc gaggaagaaa
aaaacaacat caacttcaac 2400atcgacgatc tgtcctctaa actgaacgaa
tccatcaaca aagctatgat caacatcaac 2460aagttcctga accagtgctc
tgtaagctat ctgatgaact ccatgatccc gtacggtgtt 2520aaacgtctgg
aggacttcga tgcgtctctg aaagacgccc tgctgaaata catttacgac
2580aaccgtggca ctctgatcgg tcaggttgat cgtctgaagg acaaagtgaa
caatacctta 2640tcgaccgaca tcccttttca gctcagtaaa tatgtcgata
accaacgcct tttgtccact 2700ctagactag 270914902PRTArtificial
SequenceSynthetic 14Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr
Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn
Lys Ile Trp Val Ile Pro 35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu
Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val
Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys
Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr
Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser 100 105 110Ile Val Arg
Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu
Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135
140Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser
Ala145 150 155 160Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His
Glu Val Leu Asn 165 170 175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln
Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe Thr Phe Gly Phe Glu Glu
Ser Leu Glu Val Asp Thr Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys
Phe Ala Thr Asp Pro Ala Val Thr Leu Ala 210 215 220His Glu Leu Ile
His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn225 230 235 240Pro
Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250
255Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp
260 265 270Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu
Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn
Lys Ala Lys Ser 290 295 300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr
Met Lys Asn Val Phe Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu
Asp Thr Ser Gly Lys Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp
Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn
Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu
Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375
380Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu
Ala385 390 395 400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn
Met Asn Phe Thr 405 410 415Lys Leu Lys Asn
Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val Asp
Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg 435 440
445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala Asn
450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu Gln Cys Ile Lys
Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro Ser Glu Asp Asn
Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu Ile Thr Ser Asp
Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile Ser Leu Asp Leu
Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535 540Asn Glu Pro
Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile545 550 555
560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys
565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg
Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr
Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr
Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys Val Asn Lys Ala
Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp Val Glu Gln Leu
Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650 655Ser Thr Thr
Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile 660 665 670Gly
Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val 675 680
685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro
690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser
Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp
Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp Asp Glu Val Tyr
Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys Val Asn Thr Gln
Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu Ala Leu Glu Asn
Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775 780Gln Tyr Asn
Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn785 790 795
800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln Val Asp Arg Leu
Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser Thr Asp Ile Pro
Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890 895Leu Leu Ser
Thr Leu Asp 900152736DNAArtificial SequenceSynthetic 15ctcgggattg
agggtcgttt tggcggtttc acgggcgcac gcaaatcagc gcgtaaatta 60gctaaccaga
ctagtggcgg tgggggtagt ggcggtggcg gttcgggcgg gggtgggagc
120cctaggggat ccatggagtt cgttaacaaa cagttcaact ataaagaccc
agttaacggt 180gttgacattg cttacatcaa aatcccgaac gctggccaga
tgcagccggt aaaggcattc 240aaaatccaca acaaaatctg ggttatcccg
gaacgtgata cctttactaa cccggaagaa 300ggtgacctga acccgccacc
ggaagcgaaa caggtgccgg tatcttacta tgactccacc 360tacctgtcta
ccgataacga aaaggacaac tacctgaaag gtgttactaa actgttcgag
420cgtatttact ccaccgacct gggccgtatg ctgctgacta gcatcgttcg
cggtatcccg 480ttctggggcg gttctaccat cgataccgaa ctgaaagtaa
tcgacactaa ctgcatcaac 540gttattcagc cggacggttc ctatcgttcc
gaagaactga acctggtgat catcggcccg 600tctgctgata tcatccagtt
cgagtgtaag agctttggtc acgaagttct gaacctcacc 660cgtaacggct
acggttccac tcagtacatc cgtttctctc cggacttcac cttcggtttt
720gaagaatccc tggaagtaga cacgaaccca ctgctgggcg ctggtaaatt
cgcaactgat 780cctgcggtta ccctggctca cgaactgatt catgcaggcc
accgcctgta cggtatcgcc 840atcaatccga accgtgtctt caaagttaac
accaacgcgt attacgagat gtccggtctg 900gaagttagct tcgaagaact
gcgtactttt ggcggtcacg acgctaaatt catcgactct 960ctgcaagaaa
acgagttccg tctgtactac tataacaagt tcaaagatat cgcatccacc
1020ctgaacaaag cgaaatccat cgtgggtacc actgcttctc tccagtacat
gaagaacgtt 1080tttaaagaaa aatacctgct cagcgaagac acctccggca
aattctctgt agacaagttg 1140aaattcgata aactttacaa aatgctgact
gaaatttaca ccgaagacaa cttcgttaag 1200ttctttaaag ttctgaaccg
caaaacctat ctgaacttcg acaaggcagt attcaaaatc 1260aacatcgtgc
cgaaagttaa ctacactatc tacgatggtt tcaacctgcg taacaccaac
1320ctggctgcta attttaacgg ccagaacacg gaaatcaaca acatgaactt
cacaaaactg 1380aaaaacttca ctggtctgtt cgagttttac aagctgctgt
gcgtcgacgg catcattacc 1440tccaaaacta aatctctgat agaaggtaga
aacaaagcgc tgaacgacct ctgtatcaag 1500gttaacaact gggatttatt
cttcagcccg agtgaagaca acttcaccaa cgacctgaac 1560aaaggtgaag
aaatcacctc agatactaac atcgaagcag ccgaagaaaa catctcgctg
1620gacctgatcc agcagtacta cctgaccttt aatttcgaca acgagccgga
aaacatttct 1680atcgaaaacc tgagctctga tatcatcggc cagctggaac
tgatgccgaa catcgaacgt 1740ttcccaaacg gtaaaaagta cgagctggac
aaatatacca tgttccacta cctgcgcgcg 1800caggaatttg aacacggcaa
atcccgtatc gcactgacta actccgttaa cgaagctctg 1860ctcaacccgt
cccgtgtata caccttcttc tctagcgact acgtgaaaaa ggtcaacaaa
1920gcgactgaag ctgcaatgtt cttgggttgg gttgaacagc ttgtttatga
ttttaccgac 1980gagacgtccg aagtatctac taccgacaaa attgcggata
tcactatcat catcccgtac 2040atcggtccgg ctctgaacat tggcaacatg
ctgtacaaag acgacttcgt tggcgcactg 2100atcttctccg gtgcggtgat
cctgctggag ttcatcccgg aaatcgccat cccggtactg 2160ggcacctttg
ctctggtttc ttacattgca aacaaggttc tgactgtaca aaccatcgac
2220aacgcgctga gcaaacgtaa cgaaaaatgg gatgaagttt acaaatatat
cgtgaccaac 2280tggctggcta aggttaatac tcagatcgac ctcatccgca
aaaaaatgaa agaagcactg 2340gaaaaccagg cggaagctac caaggcaatc
attaactacc agtacaacca gtacaccgag 2400gaagaaaaaa acaacatcaa
cttcaacatc gacgatctgt cctctaaact gaacgaatcc 2460atcaacaaag
ctatgatcaa catcaacaag ttcctgaacc agtgctctgt aagctatctg
2520atgaactcca tgatcccgta cggtgttaaa cgtctggagg acttcgatgc
gtctctgaaa 2580gacgccctgc tgaaatacat ttacgacaac cgtggcactc
tgatcggtca ggttgatcgt 2640ctgaaggaca aagtgaacaa taccttatcg
accgacatcc cttttcagct cagtaaatat 2700gtcgataacc aacgcctttt
gtccactcta gactag 273616911PRTArtificial SequenceSynthetic 16Leu
Gly Ile Glu Gly Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser1 5 10
15Ala Arg Lys Leu Ala Asn Gln Thr Ser Gly Gly Gly Gly Ser Gly Gly
20 25 30Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg Gly Ser Met Glu Phe
Val 35 40 45Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp
Ile Ala 50 55 60Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val
Lys Ala Phe65 70 75 80Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu
Arg Asp Thr Phe Thr 85 90 95Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro
Pro Glu Ala Lys Gln Val 100 105 110Pro Val Ser Tyr Tyr Asp Ser Thr
Tyr Leu Ser Thr Asp Asn Glu Lys 115 120 125Asp Asn Tyr Leu Lys Gly
Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser 130 135 140Thr Asp Leu Gly
Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro145 150 155 160Phe
Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr 165 170
175Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu
180 185 190Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln
Phe Glu 195 200 205Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr
Arg Asn Gly Tyr 210 215 220Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro
Asp Phe Thr Phe Gly Phe225 230 235 240Glu Glu Ser Leu Glu Val Asp
Thr Asn Pro Leu Leu Gly Ala Gly Lys 245 250 255Phe Ala Thr Asp Pro
Ala Val Thr Leu Ala His Glu Leu Ile His Ala 260 265 270Gly His Arg
Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys 275 280 285Val
Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe 290 295
300Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp
Ser305 310 315 320Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn
Lys Phe Lys Asp 325 330 335Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser
Ile Val Gly Thr Thr Ala 340 345 350Ser Leu Gln Tyr Met Lys Asn Val
Phe Lys Glu Lys Tyr Leu Leu Ser 355 360 365Glu Asp Thr Ser Gly Lys
Phe Ser Val Asp Lys Leu Lys Phe Asp Lys 370 375 380Leu Tyr Lys Met
Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys385 390 395 400Phe
Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys Ala 405 410
415Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp
420 425 430Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn
Gly Gln 435 440 445Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu
Lys Asn Phe Thr 450 455 460Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys
Val Asp Gly Ile Ile Thr465 470 475 480Ser Lys Thr Lys Ser Leu Ile
Glu Gly Arg Asn Lys Ala Leu Asn Asp 485 490 495Leu Cys Ile Lys Val
Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu 500 505 510Asp Asn Phe
Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp 515 520 525Thr
Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln 530 535
540Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile
Ser545 550 555 560Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu
Glu Leu Met Pro 565 570 575Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys
Tyr Glu Leu Asp Lys Tyr 580 585 590Thr Met Phe His Tyr Leu Arg Ala
Gln Glu Phe Glu His Gly Lys Ser 595 600 605Arg Ile Ala Leu Thr Asn
Ser Val Asn Glu Ala Leu Leu Asn Pro Ser 610 615 620Arg Val Tyr Thr
Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys625 630 635 640Ala
Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr 645 650
655Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala
660 665 670Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn
Ile Gly 675 680 685Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu
Ile Phe Ser Gly 690 695 700Ala Val Ile Leu Leu Glu Phe Ile Pro Glu
Ile Ala Ile Pro Val Leu705 710 715 720Gly Thr Phe Ala Leu Val Ser
Tyr Ile Ala Asn Lys Val Leu Thr Val 725 730 735Gln Thr Ile Asp Asn
Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu 740 745 750Val Tyr Lys
Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln 755 760 765Ile
Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala 770 775
780Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr
Glu785 790 795 800Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp
Leu Ser Ser Lys 805 810 815Leu Asn Glu Ser Ile Asn Lys Ala Met Ile
Asn Ile Asn Lys Phe Leu 820 825 830Asn Gln Cys Ser Val Ser Tyr Leu
Met Asn Ser Met Ile Pro Tyr Gly 835 840 845Val Lys Arg Leu Glu Asp
Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu 850 855 860Lys Tyr Ile Tyr
Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg865 870 875 880Leu
Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln 885 890
895Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 900
905 910172715DNAArtificial SequenceSynthetic 17ggatccgaat
tcatgccgat caccatcaac aacttcaact acagcgatcc ggtggataac 60aaaaacatcc
tgtacctgga tacccatctg aataccctgg cgaacgaacc ggaaaaagcg
120tttcgtatca ccggcaacat ttgggttatt ccggatcgtt ttagccgtaa
cagcaacccg 180aatctgaata aaccgccgcg tgttaccagc ccgaaaagcg
gttattacga tccgaactat 240ctgagcaccg atagcgataa agataccttc
ctgaaagaaa tcatcaaact gttcaaacgc 300atcaacagcc gtgaaattgg
cgaagaactg atctatcgcc tgagcaccga tattccgttt 360ccgggcaaca
acaacacccc gatcaacacc tttgatttcg atgtggattt caacagcgtt
420gatgttaaaa cccgccaggg taacaattgg gtgaaaaccg gcagcattaa
cccgagcgtg 480attattaccg gtccgcgcga aaacattatt gatccggaaa
ccagcacctt taaactgacc 540aacaacacct ttgcggcgca ggaaggtttt
ggcgcgctga gcattattag cattagcccg 600cgctttatgc tgacctatag
caacgcgacc aacgatgttg gtgaaggccg tttcagcaaa 660agcgaatttt
gcatggaccc gatcctgatc ctgatgcatg aactgaacca tgcgatgcat
720aacctgtatg gcatcgcgat tccgaacgat cagaccatta gcagcgtgac
cagcaacatc 780ttttacagcc agtacaacgt gaaactggaa tatgcggaaa
tctatgcgtt tggcggtccg 840accattgatc tgattccgaa aagcgcgcgc
aaatacttcg aagaaaaagc gctggattac 900tatcgcagca ttgcgaaacg
tctgaacagc attaccaccg cgaatccgag cagcttcaac 960aaatatatcg
gcgaatataa acagaaactg atccgcaaat atcgctttgt ggtggaaagc
1020agcggcgaag ttaccgttaa ccgcaataaa ttcgtggaac tgtacaacga
actgacccag 1080atcttcaccg aatttaacta tgcgaaaatc tataacgtgc
agaaccgtaa aatctacctg 1140agcaacgtgt ataccccggt gaccgcgaat
attctggatg ataacgtgta cgatatccag 1200aacggcttta acatcccgaa
aagcaacctg aacgttctgt ttatgggcca gaacctgagc 1260cgtaatccgg
cgctgcgtaa agtgaacccg gaaaacatgc tgtacctgtt caccaaattt
1320tgcgtcgacg cgatagatgg tagatttggc ggtttcacgg gcgcacgcaa
atcagcgcgt 1380aaattagcta accaggcgct agcgggcggt ggcggtagcg
gcggtggcgg tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtcgt
gaactgctgg tgaaaaacac cgatctgccg 1500tttattggcg atatcagcga
tgtgaaaacc gatatcttcc tgcgcaaaga tatcaacgaa 1560gaaaccgaag
tgatctacta cccggataac gtgagcgttg atcaggtgat cctgagcaaa
1620aacaccagcg aacatggtca gctggatctg ctgtatccga gcattgatag
cgaaagcgaa 1680attctgccgg gcgaaaacca ggtgttttac gataaccgta
cccagaacgt ggattacctg 1740aacagctatt actacctgga aagccagaaa
ctgagcgata acgtggaaga ttttaccttt 1800acccgcagca ttgaagaagc
gctggataac agcgcgaaag tttacaccta ttttccgacc 1860ctggcgaaca
aagttaatgc gggtgttcag ggcggtctgt ttctgatgtg ggcgaacgat
1920gtggtggaag atttcaccac caacatcctg cgtaaagata ccctggataa
aatcagcgat 1980gttagcgcga ttattccgta tattggtccg gcgctgaaca
ttagcaatag cgtgcgtcgt 2040ggcaatttta ccgaagcgtt tgcggttacc
ggtgtgacca ttctgctgga agcgtttccg 2100gaatttacca ttccggcgct
gggtgcgttt gtgatctata gcaaagtgca ggaacgcaac 2160gaaatcatca
aaaccatcga taactgcctg gaacagcgta ttaaacgctg gaaagatagc
2220tatgaatgga tgatgggcac ctggctgagc cgtattatca cccagttcaa
caacatcagc 2280taccagatgt acgatagcct gaactatcag gcgggtgcga
ttaaagcgaa aatcgatctg 2340gaatacaaaa aatacagcgg cagcgataaa
gaaaacatca aaagccaggt tgaaaacctg 2400aaaaacagcc tggatgtgaa
aattagcgaa gcgatgaata acatcaacaa attcatccgc 2460gaatgcagcg
tgacctacct gttcaaaaac atgctgccga aagtgatcga tgaactgaac
2520gaatttgatc gcaacaccaa agcgaaactg atcaacctga tcgatagcca
caacattatt 2580ctggtgggcg aagtggataa actgaaagcg aaagttaaca
acagcttcca gaacaccatc 2640ccgtttaaca tcttcagcta taccaacaac
agcctgctga aagatatcat caacgaatac 2700ttcaatctag actag
271518904PRTArtificial SequenceSynthetic 18Gly Ser Glu Phe Met Pro
Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp1 5 10 15Pro Val Asp Asn Lys
Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr 20 25 30Leu Ala Asn Glu
Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp 35 40 45Val Ile Pro
Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys 50 55 60Pro Pro
Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr65 70 75
80Leu Ser Thr Asp Ser Asp Lys Asp Thr Phe Leu Lys Glu Ile Ile Lys
85 90 95Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile
Tyr 100 105 110Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn
Thr Pro Ile 115 120 125Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser
Val Asp Val Lys Thr 130 135 140Arg Gln Gly Asn Asn Trp Val Lys Thr
Gly Ser Ile
Asn Pro Ser Val145 150 155 160Ile Ile Thr Gly Pro Arg Glu Asn Ile
Ile Asp Pro Glu Thr Ser Thr 165 170 175Phe Lys Leu Thr Asn Asn Thr
Phe Ala Ala Gln Glu Gly Phe Gly Ala 180 185 190Leu Ser Ile Ile Ser
Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn 195 200 205Ala Thr Asn
Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys 210 215 220Met
Asp Pro Ile Leu Ile Leu Met His Glu Leu Asn His Ala Met His225 230
235 240Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser
Val 245 250 255Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu
Glu Tyr Ala 260 265 270Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp
Leu Ile Pro Lys Ser 275 280 285Ala Arg Lys Tyr Phe Glu Glu Lys Ala
Leu Asp Tyr Tyr Arg Ser Ile 290 295 300Ala Lys Arg Leu Asn Ser Ile
Thr Thr Ala Asn Pro Ser Ser Phe Asn305 310 315 320Lys Tyr Ile Gly
Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe 325 330 335Val Val
Glu Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val 340 345
350Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala
355 360 365Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn
Val Tyr 370 375 380Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val
Tyr Asp Ile Gln385 390 395 400Asn Gly Phe Asn Ile Pro Lys Ser Asn
Leu Asn Val Leu Phe Met Gly 405 410 415Gln Asn Leu Ser Arg Asn Pro
Ala Leu Arg Lys Val Asn Pro Glu Asn 420 425 430Met Leu Tyr Leu Phe
Thr Lys Phe Cys Val Asp Ala Ile Asp Gly Arg 435 440 445Phe Gly Gly
Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala Asn 450 455 460Gln
Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly465 470
475 480Gly Gly Ser Ala Leu Val Leu Gln Cys Arg Glu Leu Leu Val Lys
Asn 485 490 495Thr Asp Leu Pro Phe Ile Gly Asp Ile Ser Asp Val Lys
Thr Asp Ile 500 505 510Phe Leu Arg Lys Asp Ile Asn Glu Glu Thr Glu
Val Ile Tyr Tyr Pro 515 520 525Asp Asn Val Ser Val Asp Gln Val Ile
Leu Ser Lys Asn Thr Ser Glu 530 535 540His Gly Gln Leu Asp Leu Leu
Tyr Pro Ser Ile Asp Ser Glu Ser Glu545 550 555 560Ile Leu Pro Gly
Glu Asn Gln Val Phe Tyr Asp Asn Arg Thr Gln Asn 565 570 575Val Asp
Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser 580 585
590Asp Asn Val Glu Asp Phe Thr Phe Thr Arg Ser Ile Glu Glu Ala Leu
595 600 605Asp Asn Ser Ala Lys Val Tyr Thr Tyr Phe Pro Thr Leu Ala
Asn Lys 610 615 620Val Asn Ala Gly Val Gln Gly Gly Leu Phe Leu Met
Trp Ala Asn Asp625 630 635 640Val Val Glu Asp Phe Thr Thr Asn Ile
Leu Arg Lys Asp Thr Leu Asp 645 650 655Lys Ile Ser Asp Val Ser Ala
Ile Ile Pro Tyr Ile Gly Pro Ala Leu 660 665 670Asn Ile Ser Asn Ser
Val Arg Arg Gly Asn Phe Thr Glu Ala Phe Ala 675 680 685Val Thr Gly
Val Thr Ile Leu Leu Glu Ala Phe Pro Glu Phe Thr Ile 690 695 700Pro
Ala Leu Gly Ala Phe Val Ile Tyr Ser Lys Val Gln Glu Arg Asn705 710
715 720Glu Ile Ile Lys Thr Ile Asp Asn Cys Leu Glu Gln Arg Ile Lys
Arg 725 730 735Trp Lys Asp Ser Tyr Glu Trp Met Met Gly Thr Trp Leu
Ser Arg Ile 740 745 750Ile Thr Gln Phe Asn Asn Ile Ser Tyr Gln Met
Tyr Asp Ser Leu Asn 755 760 765Tyr Gln Ala Gly Ala Ile Lys Ala Lys
Ile Asp Leu Glu Tyr Lys Lys 770 775 780Tyr Ser Gly Ser Asp Lys Glu
Asn Ile Lys Ser Gln Val Glu Asn Leu785 790 795 800Lys Asn Ser Leu
Asp Val Lys Ile Ser Glu Ala Met Asn Asn Ile Asn 805 810 815Lys Phe
Ile Arg Glu Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu 820 825
830Pro Lys Val Ile Asp Glu Leu Asn Glu Phe Asp Arg Asn Thr Lys Ala
835 840 845Lys Leu Ile Asn Leu Ile Asp Ser His Asn Ile Ile Leu Val
Gly Glu 850 855 860Val Asp Lys Leu Lys Ala Lys Val Asn Asn Ser Phe
Gln Asn Thr Ile865 870 875 880Pro Phe Asn Ile Phe Ser Tyr Thr Asn
Asn Ser Leu Leu Lys Asp Ile 885 890 895Ile Asn Glu Tyr Phe Asn Leu
Asp 900192742DNAArtificial SequenceSynthetic 19ggatccgaat
tcatgccgat caccatcaac aacttcaact acagcgatcc ggtggataac 60aaaaacatcc
tgtacctgga tacccatctg aataccctgg cgaacgaacc ggaaaaagcg
120tttcgtatca ccggcaacat ttgggttatt ccggatcgtt ttagccgtaa
cagcaacccg 180aatctgaata aaccgccgcg tgttaccagc ccgaaaagcg
gttattacga tccgaactat 240ctgagcaccg atagcgataa agataccttc
ctgaaagaaa tcatcaaact gttcaaacgc 300atcaacagcc gtgaaattgg
cgaagaactg atctatcgcc tgagcaccga tattccgttt 360ccgggcaaca
acaacacccc gatcaacacc tttgatttcg atgtggattt caacagcgtt
420gatgttaaaa cccgccaggg taacaattgg gtgaaaaccg gcagcattaa
cccgagcgtg 480attattaccg gtccgcgcga aaacattatt gatccggaaa
ccagcacctt taaactgacc 540aacaacacct ttgcggcgca ggaaggtttt
ggcgcgctga gcattattag cattagcccg 600cgctttatgc tgacctatag
caacgcgacc aacgatgttg gtgaaggccg tttcagcaaa 660agcgaatttt
gcatggaccc gatcctgatc ctgatgcatg aactgaacca tgcgatgcat
720aacctgtatg gcatcgcgat tccgaacgat cagaccatta gcagcgtgac
cagcaacatc 780ttttacagcc agtacaacgt gaaactggaa tatgcggaaa
tctatgcgtt tggcggtccg 840accattgatc tgattccgaa aagcgcgcgc
aaatacttcg aagaaaaagc gctggattac 900tatcgcagca ttgcgaaacg
tctgaacagc attaccaccg cgaatccgag cagcttcaac 960aaatatatcg
gcgaatataa acagaaactg atccgcaaat atcgctttgt ggtggaaagc
1020agcggcgaag ttaccgttaa ccgcaataaa ttcgtggaac tgtacaacga
actgacccag 1080atcttcaccg aatttaacta tgcgaaaatc tataacgtgc
agaaccgtaa aatctacctg 1140agcaacgtgt ataccccggt gaccgcgaat
attctggatg ataacgtgta cgatatccag 1200aacggcttta acatcccgaa
aagcaacctg aacgttctgt ttatgggcca gaacctgagc 1260cgtaatccgg
cgctgcgtaa agtgaacccg gaaaacatgc tgtacctgtt caccaaattt
1320tgcgtcgacg gcatcattac ctccaaaact aaatctctga tagaaggtag
atttggcggt 1380ttcacgggcg cacgcaaatc agcgcgtaaa ttagctaacc
aggcgctagc gggcggtggc 1440ggtagcggcg gtggcggtag cggcggtggc
ggtagcgcac tagtgctgca gtgtcgtgaa 1500ctgctggtga aaaacaccga
tctgccgttt attggcgata tcagcgatgt gaaaaccgat 1560atcttcctgc
gcaaagatat caacgaagaa accgaagtga tctactaccc ggataacgtg
1620agcgttgatc aggtgatcct gagcaaaaac accagcgaac atggtcagct
ggatctgctg 1680tatccgagca ttgatagcga aagcgaaatt ctgccgggcg
aaaaccaggt gttttacgat 1740aaccgtaccc agaacgtgga ttacctgaac
agctattact acctggaaag ccagaaactg 1800agcgataacg tggaagattt
tacctttacc cgcagcattg aagaagcgct ggataacagc 1860gcgaaagttt
acacctattt tccgaccctg gcgaacaaag ttaatgcggg tgttcagggc
1920ggtctgtttc tgatgtgggc gaacgatgtg gtggaagatt tcaccaccaa
catcctgcgt 1980aaagataccc tggataaaat cagcgatgtt agcgcgatta
ttccgtatat tggtccggcg 2040ctgaacatta gcaatagcgt gcgtcgtggc
aattttaccg aagcgtttgc ggttaccggt 2100gtgaccattc tgctggaagc
gtttccggaa tttaccattc cggcgctggg tgcgtttgtg 2160atctatagca
aagtgcagga acgcaacgaa atcatcaaaa ccatcgataa ctgcctggaa
2220cagcgtatta aacgctggaa agatagctat gaatggatga tgggcacctg
gctgagccgt 2280attatcaccc agttcaacaa catcagctac cagatgtacg
atagcctgaa ctatcaggcg 2340ggtgcgatta aagcgaaaat cgatctggaa
tacaaaaaat acagcggcag cgataaagaa 2400aacatcaaaa gccaggttga
aaacctgaaa aacagcctgg atgtgaaaat tagcgaagcg 2460atgaataaca
tcaacaaatt catccgcgaa tgcagcgtga cctacctgtt caaaaacatg
2520ctgccgaaag tgatcgatga actgaacgaa tttgatcgca acaccaaagc
gaaactgatc 2580aacctgatcg atagccacaa cattattctg gtgggcgaag
tggataaact gaaagcgaaa 2640gttaacaaca gcttccagaa caccatcccg
tttaacatct tcagctatac caacaacagc 2700ctgctgaaag atatcatcaa
cgaatacttc aatctagact ag 274220913PRTArtificial SequenceSynthetic
20Gly Ser Glu Phe Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp1
5 10 15Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn
Thr 20 25 30Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn
Ile Trp 35 40 45Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn
Leu Asn Lys 50 55 60Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr
Asp Pro Asn Tyr65 70 75 80Leu Ser Thr Asp Ser Asp Lys Asp Thr Phe
Leu Lys Glu Ile Ile Lys 85 90 95Leu Phe Lys Arg Ile Asn Ser Arg Glu
Ile Gly Glu Glu Leu Ile Tyr 100 105 110Arg Leu Ser Thr Asp Ile Pro
Phe Pro Gly Asn Asn Asn Thr Pro Ile 115 120 125Asn Thr Phe Asp Phe
Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr 130 135 140Arg Gln Gly
Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val145 150 155
160Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr
165 170 175Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe
Gly Ala 180 185 190Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu
Thr Tyr Ser Asn 195 200 205Ala Thr Asn Asp Val Gly Glu Gly Arg Phe
Ser Lys Ser Glu Phe Cys 210 215 220Met Asp Pro Ile Leu Ile Leu Met
His Glu Leu Asn His Ala Met His225 230 235 240Asn Leu Tyr Gly Ile
Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val 245 250 255Thr Ser Asn
Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala 260 265 270Glu
Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser 275 280
285Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile
290 295 300Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser
Phe Asn305 310 315 320Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile
Arg Lys Tyr Arg Phe 325 330 335Val Val Glu Ser Ser Gly Glu Val Thr
Val Asn Arg Asn Lys Phe Val 340 345 350Glu Leu Tyr Asn Glu Leu Thr
Gln Ile Phe Thr Glu Phe Asn Tyr Ala 355 360 365Lys Ile Tyr Asn Val
Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr 370 375 380Thr Pro Val
Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln385 390 395
400Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly
405 410 415Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro
Glu Asn 420 425 430Met Leu Tyr Leu Phe Thr Lys Phe Cys Val Asp Gly
Ile Ile Thr Ser 435 440 445Lys Thr Lys Ser Leu Ile Glu Gly Arg Phe
Gly Gly Phe Thr Gly Ala 450 455 460Arg Lys Ser Ala Arg Lys Leu Ala
Asn Gln Ala Leu Ala Gly Gly Gly465 470 475 480Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu 485 490 495Gln Cys Arg
Glu Leu Leu Val Lys Asn Thr Asp Leu Pro Phe Ile Gly 500 505 510Asp
Ile Ser Asp Val Lys Thr Asp Ile Phe Leu Arg Lys Asp Ile Asn 515 520
525Glu Glu Thr Glu Val Ile Tyr Tyr Pro Asp Asn Val Ser Val Asp Gln
530 535 540Val Ile Leu Ser Lys Asn Thr Ser Glu His Gly Gln Leu Asp
Leu Leu545 550 555 560Tyr Pro Ser Ile Asp Ser Glu Ser Glu Ile Leu
Pro Gly Glu Asn Gln 565 570 575Val Phe Tyr Asp Asn Arg Thr Gln Asn
Val Asp Tyr Leu Asn Ser Tyr 580 585 590Tyr Tyr Leu Glu Ser Gln Lys
Leu Ser Asp Asn Val Glu Asp Phe Thr 595 600 605Phe Thr Arg Ser Ile
Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr 610 615 620Thr Tyr Phe
Pro Thr Leu Ala Asn Lys Val Asn Ala Gly Val Gln Gly625 630 635
640Gly Leu Phe Leu Met Trp Ala Asn Asp Val Val Glu Asp Phe Thr Thr
645 650 655Asn Ile Leu Arg Lys Asp Thr Leu Asp Lys Ile Ser Asp Val
Ser Ala 660 665 670Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Ser
Asn Ser Val Arg 675 680 685Arg Gly Asn Phe Thr Glu Ala Phe Ala Val
Thr Gly Val Thr Ile Leu 690 695 700Leu Glu Ala Phe Pro Glu Phe Thr
Ile Pro Ala Leu Gly Ala Phe Val705 710 715 720Ile Tyr Ser Lys Val
Gln Glu Arg Asn Glu Ile Ile Lys Thr Ile Asp 725 730 735Asn Cys Leu
Glu Gln Arg Ile Lys Arg Trp Lys Asp Ser Tyr Glu Trp 740 745 750Met
Met Gly Thr Trp Leu Ser Arg Ile Ile Thr Gln Phe Asn Asn Ile 755 760
765Ser Tyr Gln Met Tyr Asp Ser Leu Asn Tyr Gln Ala Gly Ala Ile Lys
770 775 780Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly Ser Asp
Lys Glu785 790 795 800Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn
Ser Leu Asp Val Lys 805 810 815Ile Ser Glu Ala Met Asn Asn Ile Asn
Lys Phe Ile Arg Glu Cys Ser 820 825 830Val Thr Tyr Leu Phe Lys Asn
Met Leu Pro Lys Val Ile Asp Glu Leu 835 840 845Asn Glu Phe Asp Arg
Asn Thr Lys Ala Lys Leu Ile Asn Leu Ile Asp 850 855 860Ser His Asn
Ile Ile Leu Val Gly Glu Val Asp Lys Leu Lys Ala Lys865 870 875
880Val Asn Asn Ser Phe Gln Asn Thr Ile Pro Phe Asn Ile Phe Ser Tyr
885 890 895Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu Tyr Phe
Asn Leu 900 905 910Asp212673DNAArtificial SequenceSynthetic
21ggatccatgg agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac
60attgcttaca tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctc tgatagaagg tagatacggt ggtttcatgg cgctagcggg
cggtggcggt 1380agcggcggtg gcggtagcgg cggtggcggt agcgcactag
tgctgcagtg tatcaaggtt 1440aacaactggg atttattctt cagcccgagt
gaagacaact tcaccaacga cctgaacaaa 1500ggtgaagaaa tcacctcaga
tactaacatc gaagcagccg aagaaaacat ctcgctggac 1560ctgatccagc
agtactacct gacctttaat ttcgacaacg agccggaaaa catttctatc
1620gaaaacctga gctctgatat catcggccag ctggaactga tgccgaacat
cgaacgtttc 1680ccaaacggta aaaagtacga gctggacaaa tataccatgt
tccactacct gcgcgcgcag 1740gaatttgaac acggcaaatc ccgtatcgca
ctgactaact ccgttaacga agctctgctc 1800aacccgtccc gtgtatacac
cttcttctct agcgactacg tgaaaaaggt caacaaagcg 1860actgaagctg
caatgttctt gggttgggtt gaacagcttg tttatgattt taccgacgag
1920acgtccgaag tatctactac cgacaaaatt gcggatatca ctatcatcat
cccgtacatc 1980ggtccggctc tgaacattgg caacatgctg tacaaagacg
acttcgttgg cgcactgatc 2040ttctccggtg
cggtgatcct gctggagttc atcccggaaa tcgccatccc ggtactgggc
2100acctttgctc tggtttctta cattgcaaac aaggttctga ctgtacaaac
catcgacaac 2160gcgctgagca aacgtaacga aaaatgggat gaagtttaca
aatatatcgt gaccaactgg 2220ctggctaagg ttaatactca gatcgacctc
atccgcaaaa aaatgaaaga agcactggaa 2280aaccaggcgg aagctaccaa
ggcaatcatt aactaccagt acaaccagta caccgaggaa 2340gaaaaaaaca
acatcaactt caacatcgac gatctgtcct ctaaactgaa cgaatccatc
2400aacaaagcta tgatcaacat caacaagttc ctgaaccagt gctctgtaag
ctatctgatg 2460aactccatga tcccgtacgg tgttaaacgt ctggaggact
tcgatgcgtc tctgaaagac 2520gccctgctga aatacattta cgacaaccgt
ggcactctga tcggtcaggt tgatcgtctg 2580aaggacaaag tgaacaatac
cttatcgacc gacatccctt ttcagctcag taaatatgtc 2640gataaccaac
gccttttgtc cactctagac tag 267322890PRTArtificial SequenceSynthetic
22Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1
5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln
Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
Ile Pro 35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu
Asn Pro Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp
Ser Thr Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu
Lys Gly Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155
160Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn
165 170 175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe
Ser Pro 180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val
Asp Thr Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp
Pro Ala Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His
Arg Leu Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe
Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu
Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala
Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280
285Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser
290 295 300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val
Phe Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly
Lys Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys
Met Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe
Phe Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys
Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr
Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395
400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr
405 410 415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
Leu Cys 420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu
Ile Glu Gly Arg 435 440 445Tyr Gly Gly Phe Met Ala Leu Ala Gly Gly
Gly Gly Ser Gly Gly Gly 450 455 460Gly Ser Gly Gly Gly Gly Ser Ala
Leu Val Leu Gln Cys Ile Lys Val465 470 475 480Asn Asn Trp Asp Leu
Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn 485 490 495Asp Leu Asn
Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala 500 505 510Ala
Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr 515 520
525Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser
530 535 540Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu
Arg Phe545 550 555 560Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr
Thr Met Phe His Tyr 565 570 575Leu Arg Ala Gln Glu Phe Glu His Gly
Lys Ser Arg Ile Ala Leu Thr 580 585 590Asn Ser Val Asn Glu Ala Leu
Leu Asn Pro Ser Arg Val Tyr Thr Phe 595 600 605Phe Ser Ser Asp Tyr
Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala 610 615 620Met Phe Leu
Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu625 630 635
640Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile
645 650 655Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu
Tyr Lys 660 665 670Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala
Val Ile Leu Leu 675 680 685Glu Phe Ile Pro Glu Ile Ala Ile Pro Val
Leu Gly Thr Phe Ala Leu 690 695 700Val Ser Tyr Ile Ala Asn Lys Val
Leu Thr Val Gln Thr Ile Asp Asn705 710 715 720Ala Leu Ser Lys Arg
Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile 725 730 735Val Thr Asn
Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg 740 745 750Lys
Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala 755 760
765Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn
770 775 780Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu
Ser Ile785 790 795 800Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu
Asn Gln Cys Ser Val 805 810 815Ser Tyr Leu Met Asn Ser Met Ile Pro
Tyr Gly Val Lys Arg Leu Glu 820 825 830Asp Phe Asp Ala Ser Leu Lys
Asp Ala Leu Leu Lys Tyr Ile Tyr Asp 835 840 845Asn Arg Gly Thr Leu
Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val 850 855 860Asn Asn Thr
Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val865 870 875
880Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 885
890232751DNAArtificial SequenceSynthetic 23ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa 1320actaaatctc
tgatcgaagg tcgttacggt ggtttcatga cctctgaaaa atctcagacc
1380ccgctggtta ccctgttcaa aaacgctatc atcaaaaacg cttacaaaaa
aggtgaagcg 1440ctagcgggtg gtggtggttc tggtggtggt ggttctggtg
gtggtggttc tgcactagtg 1500ctgcagtgta tcaaggttaa caactgggat
ttattcttca gcccgagtga agacaacttc 1560accaacgacc tgaacaaagg
tgaagaaatc acctcagata ctaacatcga agcagccgaa 1620gaaaacatct
cgctggacct gatccagcag tactacctga cctttaattt cgacaacgag
1680ccggaaaaca tttctatcga aaacctgagc tctgatatca tcggccagct
ggaactgatg 1740ccgaacatcg aacgtttccc aaacggtaaa aagtacgagc
tggacaaata taccatgttc 1800cactacctgc gcgcgcagga atttgaacac
ggcaaatccc gtatcgcact gactaactcc 1860gttaacgaag ctctgctcaa
cccgtcccgt gtatacacct tcttctctag cgactacgtg 1920aaaaaggtca
acaaagcgac tgaagctgca atgttcttgg gttgggttga acagcttgtt
1980tatgatttta ccgacgagac gtccgaagta tctactaccg acaaaattgc
ggatatcact 2040atcatcatcc cgtacatcgg tccggctctg aacattggca
acatgctgta caaagacgac 2100ttcgttggcg cactgatctt ctccggtgcg
gtgatcctgc tggagttcat cccggaaatc 2160gccatcccgg tactgggcac
ctttgctctg gtttcttaca ttgcaaacaa ggttctgact 2220gtacaaacca
tcgacaacgc gctgagcaaa cgtaacgaaa aatgggatga agtttacaaa
2280tatatcgtga ccaactggct ggctaaggtt aatactcaga tcgacctcat
ccgcaaaaaa 2340atgaaagaag cactggaaaa ccaggcggaa gctaccaagg
caatcattaa ctaccagtac 2400aaccagtaca ccgaggaaga aaaaaacaac
atcaacttca acatcgacga tctgtcctct 2460aaactgaacg aatccatcaa
caaagctatg atcaacatca acaagttcct gaaccagtgc 2520tctgtaagct
atctgatgaa ctccatgatc ccgtacggtg ttaaacgtct ggaggacttc
2580gatgcgtctc tgaaagacgc cctgctgaaa tacatttacg acaaccgtgg
cactctgatc 2640ggtcaggttg atcgtctgaa ggacaaagtg aacaatacct
tatcgaccga catccctttt 2700cagctcagta aatatgtcga taaccaacgc
cttttgtcca ctctagacta g 275124916PRTArtificial SequenceSynthetic
24Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1
5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln
Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
Ile Pro 35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu
Asn Pro Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp
Ser Thr Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu
Lys Gly Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155
160Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn
165 170 175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe
Ser Pro 180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val
Asp Thr Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp
Pro Ala Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His
Arg Leu Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe
Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu
Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala
Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280
285Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser
290 295 300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val
Phe Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly
Lys Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys
Met Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe
Phe Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys
Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr
Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395
400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr
405 410 415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
Leu Cys 420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu
Ile Glu Gly Arg 435 440 445Tyr Gly Gly Phe Met Thr Ser Glu Lys Ser
Gln Thr Pro Leu Val Thr 450 455 460Leu Phe Lys Asn Ala Ile Ile Lys
Asn Ala Tyr Lys Lys Gly Glu Ala465 470 475 480Leu Ala Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 485 490 495Ser Ala Leu
Val Leu Gln Cys Ile Lys Val Asn Asn Trp Asp Leu Phe 500 505 510Phe
Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu 515 520
525Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser
530 535 540Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp
Asn Glu545 550 555 560Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser
Asp Ile Ile Gly Gln 565 570 575Leu Glu Leu Met Pro Asn Ile Glu Arg
Phe Pro Asn Gly Lys Lys Tyr 580 585 590Glu Leu Asp Lys Tyr Thr Met
Phe His Tyr Leu Arg Ala Gln Glu Phe 595 600 605Glu His Gly Lys Ser
Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala 610 615 620Leu Leu Asn
Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val625 630 635
640Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val
645 650 655Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val
Ser Thr 660 665 670Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro
Tyr Ile Gly Pro 675 680 685Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys
Asp Asp Phe Val Gly Ala 690 695 700Leu Ile Phe Ser Gly Ala Val Ile
Leu Leu Glu Phe Ile Pro Glu Ile705 710 715 720Ala Ile Pro Val Leu
Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn 725 730 735Lys Val Leu
Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn 740 745 750Glu
Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala 755 760
765Lys Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala
770 775 780Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr
Gln Tyr785 790 795 800Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile
Asn Phe Asn Ile Asp 805 810 815Asp Leu Ser Ser Lys Leu Asn Glu Ser
Ile Asn Lys Ala Met Ile Asn 820 825 830Ile Asn Lys Phe Leu Asn Gln
Cys Ser Val Ser Tyr Leu Met Asn Ser 835 840 845Met Ile Pro Tyr Gly
Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu 850 855 860Lys Asp Ala
Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile865 870 875
880Gly Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr
885 890 895Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg
Leu Leu 900 905 910Ser Thr Leu Asp 915252709DNAArtificial
SequenceSynthetic 25ggatccatgg agttcgttaa caaacagttc aactataaag
acccagttaa cggtgttgac 60attgcttaca tcaaaatccc gaacgctggc cagatgcagc
cggtaaaggc attcaaaatc 120cacaacaaaa tctgggttat cccggaacgt
gataccttta ctaacccgga agaaggtgac 180ctgaacccgc caccggaagc
gaaacaggtg ccggtatctt actatgactc cacctacctg 240tctaccgata
acgaaaagga caactacctg aaaggtgtta ctaaactgtt cgagcgtatt
300tactccaccg acctgggccg tatgctgctg actagcatcg ttcgcggtat
cccgttctgg 360ggcggttcta ccatcgatac cgaactgaaa gtaatcgaca
ctaactgcat caacgttatt 420cagccggacg gttcctatcg ttccgaagaa
ctgaacctgg tgatcatcgg cccgtctgct 480gatatcatcc agttcgagtg
taagagcttt ggtcacgaag ttctgaacct cacccgtaac 540ggctacggtt
ccactcagta catccgtttc tctccggact tcaccttcgg ttttgaagaa
600tccctggaag tagacacgaa cccactgctg ggcgctggta aattcgcaac
tgatcctgcg 660gttaccctgg ctcacgaact gattcatgca ggccaccgcc
tgtacggtat cgccatcaat 720ccgaaccgtg tcttcaaagt taacaccaac
gcgtattacg agatgtccgg tctggaagtt 780agcttcgaag aactgcgtac
ttttggcggt cacgacgcta aattcatcga ctctctgcaa 840gaaaacgagt
tccgtctgta ctactataac aagttcaaag atatcgcatc caccctgaac
900aaagcgaaat ccatcgtggg taccactgct tctctccagt acatgaagaa
cgtttttaaa 960gaaaaatacc tgctcagcga agacacctcc ggcaaattct
ctgtagacaa gttgaaattc 1020gataaacttt acaaaatgct gactgaaatt
tacaccgaag acaacttcgt taagttcttt 1080aaagttctga accgcaaaac
ctatctgaac ttcgacaagg cagtattcaa aatcaacatc 1140gtgccgaaag
ttaactacac tatctacgat ggtttcaacc tgcgtaacac caacctggct
1200gctaatttta acggccagaa cacggaaatc aacaacatga acttcacaaa
actgaaaaac 1260ttcactggtc tgttcgagtt ttacaagctg ctgtgcgtcg
acggcatcat tacctccaaa 1320actaaatctc tgatagaagg tagatttggc
ggtttcacgg gcgcacgcaa atcagcgcgt 1380aaacgtaaga accaggcgct
agcgggcggt ggcggtagcg gcggtggcgg tagcggcggt 1440ggcggtagcg
cactagtgct gcagtgtatc aaggttaaca actgggattt attcttcagc
1500ccgagtgaag acaacttcac caacgacctg aacaaaggtg aagaaatcac
ctcagatact 1560aacatcgaag cagccgaaga aaacatctcg ctggacctga
tccagcagta ctacctgacc 1620tttaatttcg acaacgagcc ggaaaacatt
tctatcgaaa acctgagctc tgatatcatc 1680ggccagctgg aactgatgcc
gaacatcgaa cgtttcccaa acggtaaaaa gtacgagctg 1740gacaaatata
ccatgttcca ctacctgcgc gcgcaggaat ttgaacacgg caaatcccgt
1800atcgcactga ctaactccgt taacgaagct ctgctcaacc cgtcccgtgt
atacaccttc 1860ttctctagcg actacgtgaa aaaggtcaac aaagcgactg
aagctgcaat gttcttgggt 1920tgggttgaac agcttgttta tgattttacc
gacgagacgt ccgaagtatc tactaccgac 1980aaaattgcgg atatcactat
catcatcccg tacatcggtc cggctctgaa cattggcaac 2040atgctgtaca
aagacgactt cgttggcgca ctgatcttct ccggtgcggt gatcctgctg
2100gagttcatcc cggaaatcgc catcccggta ctgggcacct ttgctctggt
ttcttacatt 2160gcaaacaagg ttctgactgt acaaaccatc gacaacgcgc
tgagcaaacg taacgaaaaa 2220tgggatgaag tttacaaata tatcgtgacc
aactggctgg ctaaggttaa tactcagatc 2280gacctcatcc gcaaaaaaat
gaaagaagca ctggaaaacc aggcggaagc taccaaggca 2340atcattaact
accagtacaa ccagtacacc gaggaagaaa aaaacaacat caacttcaac
2400atcgacgatc tgtcctctaa actgaacgaa tccatcaaca aagctatgat
caacatcaac 2460aagttcctga accagtgctc tgtaagctat ctgatgaact
ccatgatccc gtacggtgtt 2520aaacgtctgg aggacttcga tgcgtctctg
aaagacgccc tgctgaaata catttacgac 2580aaccgtggca ctctgatcgg
tcaggttgat cgtctgaagg acaaagtgaa caatacctta 2640tcgaccgaca
tcccttttca gctcagtaaa tatgtcgata accaacgcct tttgtccact
2700ctagactag 270926902PRTArtificial SequenceSynthetic 26Gly Ser
Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn
Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25
30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro
35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr
Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly
Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg
Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly
Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn
Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu
Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile
Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170
175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro
180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr
Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala
Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His Arg Leu
Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val
Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser
Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe
Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr
Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295
300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410
415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys
420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu
Gly Arg 435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys Arg Lys Asn 450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535
540Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile
Ile545 550 555 560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe
Pro Asn Gly Lys 565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe
His Tyr Leu Arg Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg
Ile Ala Leu Thr Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro
Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys
Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp
Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650
655Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile
660 665 670Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp
Phe Val 675 680 685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu
Glu Phe Ile Pro 690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe
Ala Leu Val Ser Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val
Gln Thr Ile Asp Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp
Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys
Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu
Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775
780Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe
Asn785 790 795 800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile
Asn Lys Ala Met 805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys
Ser Val Ser Tyr Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val
Lys Arg Leu Glu Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu
Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln
Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser
Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890
895Leu Leu Ser Thr Leu Asp 900272691DNAArtificial SequenceSynthetic
27ggatccatgg agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac
60attgcttaca tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctc tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa
atcagcggcg 1380ctagcgggcg gtggcggtag cggcggtggc ggtagcggcg
gtggcggtag cgcactagtg 1440ctgcagtgta tcaaggttaa caactgggat
ttattcttca gcccgagtga agacaacttc 1500accaacgacc tgaacaaagg
tgaagaaatc acctcagata ctaacatcga agcagccgaa 1560gaaaacatct
cgctggacct gatccagcag tactacctga cctttaattt cgacaacgag
1620ccggaaaaca tttctatcga aaacctgagc tctgatatca tcggccagct
ggaactgatg 1680ccgaacatcg aacgtttccc aaacggtaaa aagtacgagc
tggacaaata taccatgttc 1740cactacctgc gcgcgcagga atttgaacac
ggcaaatccc gtatcgcact gactaactcc 1800gttaacgaag ctctgctcaa
cccgtcccgt gtatacacct tcttctctag cgactacgtg 1860aaaaaggtca
acaaagcgac tgaagctgca atgttcttgg gttgggttga acagcttgtt
1920tatgatttta ccgacgagac gtccgaagta tctactaccg acaaaattgc
ggatatcact 1980atcatcatcc cgtacatcgg tccggctctg aacattggca
acatgctgta caaagacgac 2040ttcgttggcg cactgatctt ctccggtgcg
gtgatcctgc tggagttcat cccggaaatc 2100gccatcccgg tactgggcac
ctttgctctg gtttcttaca ttgcaaacaa ggttctgact 2160gtacaaacca
tcgacaacgc gctgagcaaa cgtaacgaaa aatgggatga agtttacaaa
2220tatatcgtga ccaactggct ggctaaggtt aatactcaga tcgacctcat
ccgcaaaaaa 2280atgaaagaag cactggaaaa ccaggcggaa gctaccaagg
caatcattaa ctaccagtac 2340aaccagtaca ccgaggaaga aaaaaacaac
atcaacttca acatcgacga tctgtcctct 2400aaactgaacg aatccatcaa
caaagctatg atcaacatca acaagttcct gaaccagtgc 2460tctgtaagct
atctgatgaa ctccatgatc ccgtacggtg ttaaacgtct ggaggacttc
2520gatgcgtctc tgaaagacgc cctgctgaaa tacatttacg acaaccgtgg
cactctgatc 2580ggtcaggttg atcgtctgaa ggacaaagtg aacaatacct
tatcgaccga catccctttt 2640cagctcagta aatatgtcga taaccaacgc
cttttgtcca ctctagacta g 269128896PRTArtificial SequenceSynthetic
28Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1
5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln
Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
Ile Pro 35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu
Asn Pro Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp
Ser Thr Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu
Lys Gly Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155
160Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn
165 170 175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe
Ser Pro 180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val
Asp Thr Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp
Pro Ala Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His
Arg Leu Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe
Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu
Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala
Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280
285Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser
290 295 300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val
Phe Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly
Lys Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys
Met Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe
Phe Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys
Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr
Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395
400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr
405 410 415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
Leu Cys 420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu
Ile Glu Gly Arg 435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser
Ala Ala Leu Ala Gly Gly 450 455 460Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ala Leu Val465 470 475 480Leu Gln Cys Ile Lys
Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser 485 490 495Glu Asp Asn
Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser 500 505 510Asp
Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile 515 520
525Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile
530 535 540Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu
Leu Met545 550 555 560Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys
Tyr Glu Leu Asp Lys 565 570 575Tyr Thr Met Phe His Tyr Leu Arg Ala
Gln Glu Phe Glu His Gly Lys 580 585 590Ser Arg Ile Ala Leu Thr Asn
Ser Val Asn Glu Ala Leu Leu Asn Pro 595 600 605Ser Arg Val Tyr Thr
Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn 610 615 620Lys Ala Thr
Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val625 630 635
640Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile
645 650 655Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu
Asn Ile 660 665 670Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala
Leu Ile Phe Ser 675 680 685Gly Ala Val Ile Leu Leu Glu Phe Ile Pro
Glu Ile Ala Ile Pro Val 690 695 700Leu Gly Thr Phe Ala Leu Val Ser
Tyr Ile Ala Asn Lys Val Leu Thr705 710 715 720Val Gln Thr Ile Asp
Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp 725 730 735Glu Val Tyr
Lys Tyr
Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr 740 745 750Gln Ile Asp
Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln 755 760 765Ala
Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr 770 775
780Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser
Ser785 790 795 800Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn
Ile Asn Lys Phe 805 810 815Leu Asn Gln Cys Ser Val Ser Tyr Leu Met
Asn Ser Met Ile Pro Tyr 820 825 830Gly Val Lys Arg Leu Glu Asp Phe
Asp Ala Ser Leu Lys Asp Ala Leu 835 840 845Leu Lys Tyr Ile Tyr Asp
Asn Arg Gly Thr Leu Ile Gly Gln Val Asp 850 855 860Arg Leu Lys Asp
Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe865 870 875 880Gln
Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 885 890
895292691DNAArtificial SequenceSynthetic 29ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa 1320actaaatctc
tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa atatgcggcg
1380ctagcgggcg gtggcggtag cggcggtggc ggtagcggcg gtggcggtag
cgcactagtg 1440ctgcagtgta tcaaggttaa caactgggat ttattcttca
gcccgagtga agacaacttc 1500accaacgacc tgaacaaagg tgaagaaatc
acctcagata ctaacatcga agcagccgaa 1560gaaaacatct cgctggacct
gatccagcag tactacctga cctttaattt cgacaacgag 1620ccggaaaaca
tttctatcga aaacctgagc tctgatatca tcggccagct ggaactgatg
1680ccgaacatcg aacgtttccc aaacggtaaa aagtacgagc tggacaaata
taccatgttc 1740cactacctgc gcgcgcagga atttgaacac ggcaaatccc
gtatcgcact gactaactcc 1800gttaacgaag ctctgctcaa cccgtcccgt
gtatacacct tcttctctag cgactacgtg 1860aaaaaggtca acaaagcgac
tgaagctgca atgttcttgg gttgggttga acagcttgtt 1920tatgatttta
ccgacgagac gtccgaagta tctactaccg acaaaattgc ggatatcact
1980atcatcatcc cgtacatcgg tccggctctg aacattggca acatgctgta
caaagacgac 2040ttcgttggcg cactgatctt ctccggtgcg gtgatcctgc
tggagttcat cccggaaatc 2100gccatcccgg tactgggcac ctttgctctg
gtttcttaca ttgcaaacaa ggttctgact 2160gtacaaacca tcgacaacgc
gctgagcaaa cgtaacgaaa aatgggatga agtttacaaa 2220tatatcgtga
ccaactggct ggctaaggtt aatactcaga tcgacctcat ccgcaaaaaa
2280atgaaagaag cactggaaaa ccaggcggaa gctaccaagg caatcattaa
ctaccagtac 2340aaccagtaca ccgaggaaga aaaaaacaac atcaacttca
acatcgacga tctgtcctct 2400aaactgaacg aatccatcaa caaagctatg
atcaacatca acaagttcct gaaccagtgc 2460tctgtaagct atctgatgaa
ctccatgatc ccgtacggtg ttaaacgtct ggaggacttc 2520gatgcgtctc
tgaaagacgc cctgctgaaa tacatttacg acaaccgtgg cactctgatc
2580ggtcaggttg atcgtctgaa ggacaaagtg aacaatacct tatcgaccga
catccctttt 2640cagctcagta aatatgtcga taaccaacgc cttttgtcca
ctctagacta g 269130896PRTArtificial SequenceSynthetic 30Gly Ser Met
Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln
Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40
45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro
50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr
Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val
Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185
190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro
195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310
315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425
430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg
435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Tyr Ala Ala Leu Ala
Gly Gly 450 455 460Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Leu Val465 470 475 480Leu Gln Cys Ile Lys Val Asn Asn Trp
Asp Leu Phe Phe Ser Pro Ser 485 490 495Glu Asp Asn Phe Thr Asn Asp
Leu Asn Lys Gly Glu Glu Ile Thr Ser 500 505 510Asp Thr Asn Ile Glu
Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile 515 520 525Gln Gln Tyr
Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile 530 535 540Ser
Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met545 550
555 560Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp
Lys 565 570 575Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu
His Gly Lys 580 585 590Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu
Ala Leu Leu Asn Pro 595 600 605Ser Arg Val Tyr Thr Phe Phe Ser Ser
Asp Tyr Val Lys Lys Val Asn 610 615 620Lys Ala Thr Glu Ala Ala Met
Phe Leu Gly Trp Val Glu Gln Leu Val625 630 635 640Tyr Asp Phe Thr
Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile 645 650 655Ala Asp
Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile 660 665
670Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser
675 680 685Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile
Pro Val 690 695 700Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn
Lys Val Leu Thr705 710 715 720Val Gln Thr Ile Asp Asn Ala Leu Ser
Lys Arg Asn Glu Lys Trp Asp 725 730 735Glu Val Tyr Lys Tyr Ile Val
Thr Asn Trp Leu Ala Lys Val Asn Thr 740 745 750Gln Ile Asp Leu Ile
Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln 755 760 765Ala Glu Ala
Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr 770 775 780Glu
Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser785 790
795 800Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys
Phe 805 810 815Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met
Ile Pro Tyr 820 825 830Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser
Leu Lys Asp Ala Leu 835 840 845Leu Lys Tyr Ile Tyr Asp Asn Arg Gly
Thr Leu Ile Gly Gln Val Asp 850 855 860Arg Leu Lys Asp Lys Val Asn
Asn Thr Leu Ser Thr Asp Ile Pro Phe865 870 875 880Gln Leu Ser Lys
Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 885 890
895312691DNAArtificial SequenceSynthetic 31ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa 1320actaaatctc
tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa atcatatgcg
1380ctagcgggcg gtggcggtag cggcggtggc ggtagcggcg gtggcggtag
cgcactagtg 1440ctgcagtgta tcaaggttaa caactgggat ttattcttca
gcccgagtga agacaacttc 1500accaacgacc tgaacaaagg tgaagaaatc
acctcagata ctaacatcga agcagccgaa 1560gaaaacatct cgctggacct
gatccagcag tactacctga cctttaattt cgacaacgag 1620ccggaaaaca
tttctatcga aaacctgagc tctgatatca tcggccagct ggaactgatg
1680ccgaacatcg aacgtttccc aaacggtaaa aagtacgagc tggacaaata
taccatgttc 1740cactacctgc gcgcgcagga atttgaacac ggcaaatccc
gtatcgcact gactaactcc 1800gttaacgaag ctctgctcaa cccgtcccgt
gtatacacct tcttctctag cgactacgtg 1860aaaaaggtca acaaagcgac
tgaagctgca atgttcttgg gttgggttga acagcttgtt 1920tatgatttta
ccgacgagac gtccgaagta tctactaccg acaaaattgc ggatatcact
1980atcatcatcc cgtacatcgg tccggctctg aacattggca acatgctgta
caaagacgac 2040ttcgttggcg cactgatctt ctccggtgcg gtgatcctgc
tggagttcat cccggaaatc 2100gccatcccgg tactgggcac ctttgctctg
gtttcttaca ttgcaaacaa ggttctgact 2160gtacaaacca tcgacaacgc
gctgagcaaa cgtaacgaaa aatgggatga agtttacaaa 2220tatatcgtga
ccaactggct ggctaaggtt aatactcaga tcgacctcat ccgcaaaaaa
2280atgaaagaag cactggaaaa ccaggcggaa gctaccaagg caatcattaa
ctaccagtac 2340aaccagtaca ccgaggaaga aaaaaacaac atcaacttca
acatcgacga tctgtcctct 2400aaactgaacg aatccatcaa caaagctatg
atcaacatca acaagttcct gaaccagtgc 2460tctgtaagct atctgatgaa
ctccatgatc ccgtacggtg ttaaacgtct ggaggacttc 2520gatgcgtctc
tgaaagacgc cctgctgaaa tacatttacg acaaccgtgg cactctgatc
2580ggtcaggttg atcgtctgaa ggacaaagtg aacaatacct tatcgaccga
catccctttt 2640cagctcagta aatatgtcga taaccaacgc cttttgtcca
ctctagacta g 269132896PRTArtificial SequenceSynthetic 32Gly Ser Met
Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln
Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40
45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro
50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr
Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val
Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185
190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro
195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310
315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425
430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg
435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Tyr Ala Leu Ala
Gly Gly 450 455 460Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Leu Val465 470 475 480Leu Gln Cys Ile Lys Val Asn Asn Trp
Asp Leu Phe Phe Ser Pro Ser 485 490 495Glu Asp Asn Phe Thr Asn Asp
Leu Asn Lys Gly Glu Glu Ile Thr Ser 500 505
510Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile
515 520 525Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu
Asn Ile 530 535 540Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln
Leu Glu Leu Met545 550 555 560Pro Asn Ile Glu Arg Phe Pro Asn Gly
Lys Lys Tyr Glu Leu Asp Lys 565 570 575Tyr Thr Met Phe His Tyr Leu
Arg Ala Gln Glu Phe Glu His Gly Lys 580 585 590Ser Arg Ile Ala Leu
Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro 595 600 605Ser Arg Val
Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn 610 615 620Lys
Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val625 630
635 640Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys
Ile 645 650 655Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala
Leu Asn Ile 660 665 670Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly
Ala Leu Ile Phe Ser 675 680 685Gly Ala Val Ile Leu Leu Glu Phe Ile
Pro Glu Ile Ala Ile Pro Val 690 695 700Leu Gly Thr Phe Ala Leu Val
Ser Tyr Ile Ala Asn Lys Val Leu Thr705 710 715 720Val Gln Thr Ile
Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp 725 730 735Glu Val
Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr 740 745
750Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln
755 760 765Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln
Tyr Thr 770 775 780Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp
Asp Leu Ser Ser785 790 795 800Lys Leu Asn Glu Ser Ile Asn Lys Ala
Met Ile Asn Ile Asn Lys Phe 805 810 815Leu Asn Gln Cys Ser Val Ser
Tyr Leu Met Asn Ser Met Ile Pro Tyr 820 825 830Gly Val Lys Arg Leu
Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu 835 840 845Leu Lys Tyr
Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp 850 855 860Arg
Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe865 870
875 880Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu
Asp 885 890 895332709DNAArtificial SequenceSynthetic 33ggatccatgg
agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca
tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctc tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa
atcagcgcgt 1380aaatatgcta accaggcgct agcgggcggt ggcggtagcg
gcggtggcgg tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtatc
aaggttaaca actgggattt attcttcagc 1500ccgagtgaag acaacttcac
caacgacctg aacaaaggtg aagaaatcac ctcagatact 1560aacatcgaag
cagccgaaga aaacatctcg ctggacctga tccagcagta ctacctgacc
1620tttaatttcg acaacgagcc ggaaaacatt tctatcgaaa acctgagctc
tgatatcatc 1680ggccagctgg aactgatgcc gaacatcgaa cgtttcccaa
acggtaaaaa gtacgagctg 1740gacaaatata ccatgttcca ctacctgcgc
gcgcaggaat ttgaacacgg caaatcccgt 1800atcgcactga ctaactccgt
taacgaagct ctgctcaacc cgtcccgtgt atacaccttc 1860ttctctagcg
actacgtgaa aaaggtcaac aaagcgactg aagctgcaat gttcttgggt
1920tgggttgaac agcttgttta tgattttacc gacgagacgt ccgaagtatc
tactaccgac 1980aaaattgcgg atatcactat catcatcccg tacatcggtc
cggctctgaa cattggcaac 2040atgctgtaca aagacgactt cgttggcgca
ctgatcttct ccggtgcggt gatcctgctg 2100gagttcatcc cggaaatcgc
catcccggta ctgggcacct ttgctctggt ttcttacatt 2160gcaaacaagg
ttctgactgt acaaaccatc gacaacgcgc tgagcaaacg taacgaaaaa
2220tgggatgaag tttacaaata tatcgtgacc aactggctgg ctaaggttaa
tactcagatc 2280gacctcatcc gcaaaaaaat gaaagaagca ctggaaaacc
aggcggaagc taccaaggca 2340atcattaact accagtacaa ccagtacacc
gaggaagaaa aaaacaacat caacttcaac 2400atcgacgatc tgtcctctaa
actgaacgaa tccatcaaca aagctatgat caacatcaac 2460aagttcctga
accagtgctc tgtaagctat ctgatgaact ccatgatccc gtacggtgtt
2520aaacgtctgg aggacttcga tgcgtctctg aaagacgccc tgctgaaata
catttacgac 2580aaccgtggca ctctgatcgg tcaggttgat cgtctgaagg
acaaagtgaa caatacctta 2640tcgaccgaca tcccttttca gctcagtaaa
tatgtcgata accaacgcct tttgtccact 2700ctagactag
270934902PRTArtificial SequenceSynthetic 34Gly Ser Met Glu Phe Val
Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile
Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40 45Glu Arg Asp
Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro Glu
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75
80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu
85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr
Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile
Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val
Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu Leu Asn Leu
Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile Gln Phe Glu
Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu Thr Arg Asn
Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 195 200
205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala
210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala
Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu Glu Leu
Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp Ser Leu
Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile Val Gly
Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310 315
320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp
325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn
Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile
Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe
Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys
Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val
Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg 435 440
445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Tyr Ala Asn
450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu Gln Cys Ile Lys
Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro Ser Glu Asp Asn
Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu Ile Thr Ser Asp
Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile Ser Leu Asp Leu
Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535 540Asn Glu Pro
Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile545 550 555
560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys
565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg
Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr
Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr
Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys Val Asn Lys Ala
Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp Val Glu Gln Leu
Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650 655Ser Thr Thr
Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile 660 665 670Gly
Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val 675 680
685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro
690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser
Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp
Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp Asp Glu Val Tyr
Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys Val Asn Thr Gln
Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu Ala Leu Glu Asn
Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775 780Gln Tyr Asn
Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn785 790 795
800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln Val Asp Arg Leu
Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser Thr Asp Ile Pro
Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890 895Leu Leu Ser
Thr Leu Asp 900352697DNAArtificial SequenceSynthetic 35ggatccatgg
agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca
tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctc tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa
atcagcgcgt 1380aaagcgctag cgggcggtgg cggtagcggc ggtggcggta
gcggcggtgg cggtagcgca 1440ctagtgctgc agtgtatcaa ggttaacaac
tgggatttat tcttcagccc gagtgaagac 1500aacttcacca acgacctgaa
caaaggtgaa gaaatcacct cagatactaa catcgaagca 1560gccgaagaaa
acatctcgct ggacctgatc cagcagtact acctgacctt taatttcgac
1620aacgagccgg aaaacatttc tatcgaaaac ctgagctctg atatcatcgg
ccagctggaa 1680ctgatgccga acatcgaacg tttcccaaac ggtaaaaagt
acgagctgga caaatatacc 1740atgttccact acctgcgcgc gcaggaattt
gaacacggca aatcccgtat cgcactgact 1800aactccgtta acgaagctct
gctcaacccg tcccgtgtat acaccttctt ctctagcgac 1860tacgtgaaaa
aggtcaacaa agcgactgaa gctgcaatgt tcttgggttg ggttgaacag
1920cttgtttatg attttaccga cgagacgtcc gaagtatcta ctaccgacaa
aattgcggat 1980atcactatca tcatcccgta catcggtccg gctctgaaca
ttggcaacat gctgtacaaa 2040gacgacttcg ttggcgcact gatcttctcc
ggtgcggtga tcctgctgga gttcatcccg 2100gaaatcgcca tcccggtact
gggcaccttt gctctggttt cttacattgc aaacaaggtt 2160ctgactgtac
aaaccatcga caacgcgctg agcaaacgta acgaaaaatg ggatgaagtt
2220tacaaatata tcgtgaccaa ctggctggct aaggttaata ctcagatcga
cctcatccgc 2280aaaaaaatga aagaagcact ggaaaaccag gcggaagcta
ccaaggcaat cattaactac 2340cagtacaacc agtacaccga ggaagaaaaa
aacaacatca acttcaacat cgacgatctg 2400tcctctaaac tgaacgaatc
catcaacaaa gctatgatca acatcaacaa gttcctgaac 2460cagtgctctg
taagctatct gatgaactcc atgatcccgt acggtgttaa acgtctggag
2520gacttcgatg cgtctctgaa agacgccctg ctgaaataca tttacgacaa
ccgtggcact 2580ctgatcggtc aggttgatcg tctgaaggac aaagtgaaca
ataccttatc gaccgacatc 2640ccttttcagc tcagtaaata tgtcgataac
caacgccttt tgtccactct agactag 269736898PRTArtificial
SequenceSynthetic 36Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr
Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn
Lys Ile Trp Val Ile Pro 35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu
Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val
Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys
Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr
Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser 100 105 110Ile Val Arg
Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu
Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135
140Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser
Ala145 150 155 160Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His
Glu Val Leu Asn 165 170 175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln
Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe Thr Phe Gly Phe Glu Glu
Ser Leu Glu Val Asp Thr Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys
Phe Ala Thr Asp Pro Ala Val Thr Leu Ala 210 215 220His Glu Leu Ile
His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn225 230 235 240Pro
Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250
255Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp
260
265 270Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr
Tyr 275 280 285Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys
Ala Lys Ser 290 295 300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met
Lys Asn Val Phe Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp
Thr Ser Gly Lys Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys
Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe
Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn
Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375
380Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu
Ala385 390 395 400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn
Met Asn Phe Thr 405 410 415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu
Phe Tyr Lys Leu Leu Cys 420 425 430Val Asp Gly Ile Ile Thr Ser Lys
Thr Lys Ser Leu Ile Glu Gly Arg 435 440 445Phe Gly Gly Phe Thr Gly
Ala Arg Lys Ser Ala Arg Lys Ala Leu Ala 450 455 460Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala465 470 475 480Leu
Val Leu Gln Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser 485 490
495Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile
500 505 510Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser
Leu Asp 515 520 525Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp
Asn Glu Pro Glu 530 535 540Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp
Ile Ile Gly Gln Leu Glu545 550 555 560Leu Met Pro Asn Ile Glu Arg
Phe Pro Asn Gly Lys Lys Tyr Glu Leu 565 570 575Asp Lys Tyr Thr Met
Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His 580 585 590Gly Lys Ser
Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu 595 600 605Asn
Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys 610 615
620Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu
Gln625 630 635 640Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val
Ser Thr Thr Asp 645 650 655Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro
Tyr Ile Gly Pro Ala Leu 660 665 670Asn Ile Gly Asn Met Leu Tyr Lys
Asp Asp Phe Val Gly Ala Leu Ile 675 680 685Phe Ser Gly Ala Val Ile
Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile 690 695 700Pro Val Leu Gly
Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val705 710 715 720Leu
Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys 725 730
735Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val
740 745 750Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala
Leu Glu 755 760 765Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr
Gln Tyr Asn Gln 770 775 780Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn
Phe Asn Ile Asp Asp Leu785 790 795 800Ser Ser Lys Leu Asn Glu Ser
Ile Asn Lys Ala Met Ile Asn Ile Asn 805 810 815Lys Phe Leu Asn Gln
Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile 820 825 830Pro Tyr Gly
Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp 835 840 845Ala
Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln 850 855
860Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp
Ile865 870 875 880Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg
Leu Leu Ser Thr 885 890 895Leu Asp3751DNAArtificial
SequenceSynthetic 37tttggcggtt tcacgggcgc acgcaaatca gcgcgtaaat
tagctaacca g 513817PRTArtificial SequenceSynthetic 38Phe Gly Gly
Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala Asn1 5 10
15Gln3933DNAArtificial SequenceSynthetic 39tttggcggtt tcacgggcgc
acgcaaatca gcg 334011PRTArtificial SequenceSynthetic 40Phe Gly Gly
Phe Thr Gly Ala Arg Lys Ser Ala1 5 104133DNAArtificial
SequenceSynthetic 41tttggcggtt tcacgggcgc acgcaaatat gcg
334211PRTArtificial SequenceSynthetic 42Phe Gly Gly Phe Thr Gly Ala
Arg Lys Tyr Ala1 5 104333DNAArtificial SequenceSynthetic
43tttggcggtt tcacgggcgc acgcaaatca tat 334411PRTArtificial
SequenceSynthetic 44Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Tyr1 5
104551DNAArtificial SequenceSynthetic 45tttggcggtt tcacgggcgc
acgcaaatca gcgcgtaaat atgctaacca g 514617PRTArtificial
SequenceSynthetic 46Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys Tyr Ala Asn1 5 10 15Gln4739DNAArtificial SequenceSynthetic
47tttggcggtt tcacgggcgc acgcaaatca gcgcgtaaa 394813PRTArtificial
SequenceSynthetic 48Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys1 5 104951DNAArtificial SequenceSynthetic 49tttggcggtt
tcacgggcgc acgcaaatca gcgcgtaaac gcaaaaacca g 515017PRTArtificial
SequenceSynthetic 50Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys Arg Lys Asn1 5 10 15Gln512736DNAArtificial SequenceSynthetic
51ctcgggattg agggtcgttt tggcggtttc acgggcgcac gcaaatcagc gcgtaaatta
60gctaaccaga ctagtggcgg tgggggtagt ggcggtggcg gttcgggcgg gggtgggagc
120cctaggggat ccatggagtt cgttaacaaa cagttcaact ataaagaccc
agttaacggt 180gttgacattg cttacatcaa aatcccgaac gctggccaga
tgcagccggt aaaggcattc 240aaaatccaca acaaaatctg ggttatcccg
gaacgtgata cctttactaa cccggaagaa 300ggtgacctga acccgccacc
ggaagcgaaa caggtgccgg tatcttacta tgactccacc 360tacctgtcta
ccgataacga aaaggacaac tacctgaaag gtgttactaa actgttcgag
420cgtatttact ccaccgacct gggccgtatg ctgctgacta gcatcgttcg
cggtatcccg 480ttctggggcg gttctaccat cgataccgaa ctgaaagtaa
tcgacactaa ctgcatcaac 540gttattcagc cggacggttc ctatcgttcc
gaagaactga acctggtgat catcggcccg 600tctgctgata tcatccagtt
cgagtgtaag agctttggtc acgaagttct gaacctcacc 660cgtaacggct
acggttccac tcagtacatc cgtttctctc cggacttcac cttcggtttt
720gaagaatccc tggaagtaga cacgaaccca ctgctgggcg ctggtaaatt
cgcaactgat 780cctgcggtta ccctggctca cgaactgatt catgcaggcc
accgcctgta cggtatcgcc 840atcaatccga accgtgtctt caaagttaac
accaacgcgt attacgagat gtccggtctg 900gaagttagct tcgaagaact
gcgtactttt ggcggtcacg acgctaaatt catcgactct 960ctgcaagaaa
acgagttccg tctgtactac tataacaagt tcaaagatat cgcatccacc
1020ctgaacaaag cgaaatccat cgtgggtacc actgcttctc tccagtacat
gaagaacgtt 1080tttaaagaaa aatacctgct cagcgaagac acctccggca
aattctctgt agacaagttg 1140aaattcgata aactttacaa aatgctgact
gaaatttaca ccgaagacaa cttcgttaag 1200ttctttaaag ttctgaaccg
caaaacctat ctgaacttcg acaaggcagt attcaaaatc 1260aacatcgtgc
cgaaagttaa ctacactatc tacgatggtt tcaacctgcg taacaccaac
1320ctggctgcta attttaacgg ccagaacacg gaaatcaaca acatgaactt
cacaaaactg 1380aaaaacttca ctggtctgtt cgagttttac aagctgctgt
gcgtcgacgg catcattacc 1440tccaaaacta aatctctgat agaaggtaga
aacaaagcgc tgaacctgca gtgtatcaag 1500gttaacaact gggatttatt
cttcagcccg agtgaagaca acttcaccaa cgacctgaac 1560aaaggtgaag
aaatcacctc agatactaac atcgaagcag ccgaagaaaa catctcgctg
1620gacctgatcc agcagtacta cctgaccttt aatttcgaca acgagccgga
aaacatttct 1680atcgaaaacc tgagctctga tatcatcggc cagctggaac
tgatgccgaa catcgaacgt 1740ttcccaaacg gtaaaaagta cgagctggac
aaatatacca tgttccacta cctgcgcgcg 1800caggaatttg aacacggcaa
atcccgtatc gcactgacta actccgttaa cgaagctctg 1860ctcaacccgt
cccgtgtata caccttcttc tctagcgact acgtgaaaaa ggtcaacaaa
1920gcgactgaag ctgcaatgtt cttgggttgg gttgaacagc ttgtttatga
ttttaccgac 1980gagacgtccg aagtatctac taccgacaaa attgcggata
tcactatcat catcccgtac 2040atcggtccgg ctctgaacat tggcaacatg
ctgtacaaag acgacttcgt tggcgcactg 2100atcttctccg gtgcggtgat
cctgctggag ttcatcccgg aaatcgccat cccggtactg 2160ggcacctttg
ctctggtttc ttacattgca aacaaggttc tgactgtaca aaccatcgac
2220aacgcgctga gcaaacgtaa cgaaaaatgg gatgaagttt acaaatatat
cgtgaccaac 2280tggctggcta aggttaatac tcagatcgac ctcatccgca
aaaaaatgaa agaagcactg 2340gaaaaccagg cggaagctac caaggcaatc
attaactacc agtacaacca gtacaccgag 2400gaagaaaaaa acaacatcaa
cttcaacatc gacgatctgt cctctaaact gaacgaatcc 2460atcaacaaag
ctatgatcaa catcaacaag ttcctgaacc agtgctctgt aagctatctg
2520atgaactcca tgatcccgta cggtgttaaa cgtctggagg acttcgatgc
gtctctgaaa 2580gacgccctgc tgaaatacat ttacgacaac cgtggcactc
tgatcggtca ggttgatcgt 2640ctgaaggaca aagtgaacaa taccttatcg
accgacatcc cttttcagct cagtaaatat 2700gtcgataacc aacgcctttt
gtccactcta gactag 273652911PRTArtificial SequenceSynthetic 52Leu
Gly Ile Glu Gly Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser1 5 10
15Ala Arg Lys Leu Ala Asn Gln Thr Ser Gly Gly Gly Gly Ser Gly Gly
20 25 30Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg Gly Ser Met Glu Phe
Val 35 40 45Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp
Ile Ala 50 55 60Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val
Lys Ala Phe65 70 75 80Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu
Arg Asp Thr Phe Thr 85 90 95Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro
Pro Glu Ala Lys Gln Val 100 105 110Pro Val Ser Tyr Tyr Asp Ser Thr
Tyr Leu Ser Thr Asp Asn Glu Lys 115 120 125Asp Asn Tyr Leu Lys Gly
Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser 130 135 140Thr Asp Leu Gly
Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro145 150 155 160Phe
Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr 165 170
175Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu
180 185 190Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln
Phe Glu 195 200 205Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr
Arg Asn Gly Tyr 210 215 220Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro
Asp Phe Thr Phe Gly Phe225 230 235 240Glu Glu Ser Leu Glu Val Asp
Thr Asn Pro Leu Leu Gly Ala Gly Lys 245 250 255Phe Ala Thr Asp Pro
Ala Val Thr Leu Ala His Glu Leu Ile His Ala 260 265 270Gly His Arg
Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys 275 280 285Val
Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe 290 295
300Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp
Ser305 310 315 320Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn
Lys Phe Lys Asp 325 330 335Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser
Ile Val Gly Thr Thr Ala 340 345 350Ser Leu Gln Tyr Met Lys Asn Val
Phe Lys Glu Lys Tyr Leu Leu Ser 355 360 365Glu Asp Thr Ser Gly Lys
Phe Ser Val Asp Lys Leu Lys Phe Asp Lys 370 375 380Leu Tyr Lys Met
Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys385 390 395 400Phe
Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys Ala 405 410
415Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp
420 425 430Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn
Gly Gln 435 440 445Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu
Lys Asn Phe Thr 450 455 460Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys
Val Asp Gly Ile Ile Thr465 470 475 480Ser Lys Thr Lys Ser Leu Ile
Glu Gly Arg Asn Lys Ala Leu Asn Leu 485 490 495Gln Cys Ile Lys Val
Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu 500 505 510Asp Asn Phe
Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp 515 520 525Thr
Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln 530 535
540Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile
Ser545 550 555 560Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu
Glu Leu Met Pro 565 570 575Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys
Tyr Glu Leu Asp Lys Tyr 580 585 590Thr Met Phe His Tyr Leu Arg Ala
Gln Glu Phe Glu His Gly Lys Ser 595 600 605Arg Ile Ala Leu Thr Asn
Ser Val Asn Glu Ala Leu Leu Asn Pro Ser 610 615 620Arg Val Tyr Thr
Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys625 630 635 640Ala
Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr 645 650
655Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala
660 665 670Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn
Ile Gly 675 680 685Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu
Ile Phe Ser Gly 690 695 700Ala Val Ile Leu Leu Glu Phe Ile Pro Glu
Ile Ala Ile Pro Val Leu705 710 715 720Gly Thr Phe Ala Leu Val Ser
Tyr Ile Ala Asn Lys Val Leu Thr Val 725 730 735Gln Thr Ile Asp Asn
Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu 740 745 750Val Tyr Lys
Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln 755 760 765Ile
Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala 770 775
780Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr
Glu785 790 795 800Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp
Leu Ser Ser Lys 805 810 815Leu Asn Glu Ser Ile Asn Lys Ala Met Ile
Asn Ile Asn Lys Phe Leu 820 825 830Asn Gln Cys Ser Val Ser Tyr Leu
Met Asn Ser Met Ile Pro Tyr Gly 835 840 845Val Lys Arg Leu Glu Asp
Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu 850 855 860Lys Tyr Ile Tyr
Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg865 870 875 880Leu
Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln 885 890
895Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 900
905 91053177DNAArtificial SequenceSynthetic 53ggatccacgc acgtcgacgg
catcattacc tccaaaacta aatctctgat agaaggtaga 60tttggcggtt tcacgggcgc
acgcaaatca gcgcgtaaat tagctaacca ggcgctagcg 120ggtggtggtg
gttctgcact agtgctgcag acgcacggtc tagaatgata aaagctt
17754192DNAArtificial SequenceSynthetic 54ggatccacgc acgtcgacgg
catcattacc tccaaaacta aatctctgat agaaggtaga 60tttggcggtt tcacgggcgc
acgcaaatca gcgcgtaaat tagctaacca ggcgctagcg 120ggtggtggtg
gttctggtgg tggtggttct gcactagtgc tgcagacgca cggtctagaa
180tgataaaagc tt 19255222DNAArtificial SequenceSynthetic
55ggatccacgc acgtcgacgg catcattacc tccaaaacta aatctctgat agaaggtaga
60tttggcggtt tcacgggcgc acgcaaatca gcgcgtaaat tagctaacca ggcgctagcg
120ggtggtggtg gttctggtgg tggtggttct ggtggtggtg gttctggtgg
tggtggttct 180gcactagtgc tgcagacgca cggtctagaa tgataaaagc tt
22256237DNAArtificial SequenceSynthetic 56ggatccacgc acgtcgacgg
catcattacc tccaaaacta aatctctgat agaaggtaga 60tttggcggtt tcacgggcgc
acgcaaatca gcgcgtaaat tagctaacca ggcgctagcg 120ggtggtggtg
gttctggtgg tggtggttct ggtggtggtg gttctggtgg tggtggttct
180ggtggtggtg gttctgcact agtgctgcag acgcacggtc tagaatgata aaagctt
23757228DNAArtificial SequenceSynthetic 57ggatccacgc acgtcgacgg
catcattacc tccaaaacta aatctctgat agaaggtaga 60tttggcggtt tcacgggcgc
acgcaaatca gcgcgtaaat tagctaacca ggcgctagcg 120gctgaagctg
ctgctaaaga agctgctgct aaagaagctg ctgctaaagc tggtggcggt
180ggttccgcac tagtgctgca gacgcacggt ctagaatgat
aaaagctt 228582694DNAArtificial SequenceSynthetic 58ggatccatgg
agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca
tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctc tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa
atcagcgcgt 1380aaattagcta accaggcgct agcgggtggt ggtggttctg
gtggtggtgg ttctgcacta 1440gtgctgcagt gtatcaaggt taacaactgg
gatttattct tcagcccgag tgaagacaac 1500ttcaccaacg acctgaacaa
aggtgaagaa atcacctcag atactaacat cgaagcagcc 1560gaagaaaaca
tctcgctgga cctgatccag cagtactacc tgacctttaa tttcgacaac
1620gagccggaaa acatttctat cgaaaacctg agctctgata tcatcggcca
gctggaactg 1680atgccgaaca tcgaacgttt cccaaacggt aaaaagtacg
agctggacaa atataccatg 1740ttccactacc tgcgcgcgca ggaatttgaa
cacggcaaat cccgtatcgc actgactaac 1800tccgttaacg aagctctgct
caacccgtcc cgtgtataca ccttcttctc tagcgactac 1860gtgaaaaagg
tcaacaaagc gactgaagct gcaatgttct tgggttgggt tgaacagctt
1920gtttatgatt ttaccgacga gacgtccgaa gtatctacta ccgacaaaat
tgcggatatc 1980actatcatca tcccgtacat cggtccggct ctgaacattg
gcaacatgct gtacaaagac 2040gacttcgttg gcgcactgat cttctccggt
gcggtgatcc tgctggagtt catcccggaa 2100atcgccatcc cggtactggg
cacctttgct ctggtttctt acattgcaaa caaggttctg 2160actgtacaaa
ccatcgacaa cgcgctgagc aaacgtaacg aaaaatggga tgaagtttac
2220aaatatatcg tgaccaactg gctggctaag gttaatactc agatcgacct
catccgcaaa 2280aaaatgaaag aagcactgga aaaccaggcg gaagctacca
aggcaatcat taactaccag 2340tacaaccagt acaccgagga agaaaaaaac
aacatcaact tcaacatcga cgatctgtcc 2400tctaaactga acgaatccat
caacaaagct atgatcaaca tcaacaagtt cctgaaccag 2460tgctctgtaa
gctatctgat gaactccatg atcccgtacg gtgttaaacg tctggaggac
2520ttcgatgcgt ctctgaaaga cgccctgctg aaatacattt acgacaaccg
tggcactctg 2580atcggtcagg ttgatcgtct gaaggacaaa gtgaacaata
ccttatcgac cgacatccct 2640tttcagctca gtaaatatgt cgataaccaa
cgccttttgt ccactctaga ctag 269459897PRTArtificial SequenceSynthetic
59Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1
5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln
Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
Ile Pro 35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu
Asn Pro Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp
Ser Thr Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu
Lys Gly Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155
160Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn
165 170 175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe
Ser Pro 180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val
Asp Thr Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp
Pro Ala Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His
Arg Leu Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe
Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu
Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala
Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280
285Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser
290 295 300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val
Phe Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly
Lys Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys
Met Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe
Phe Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys
Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr
Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395
400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr
405 410 415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
Leu Cys 420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu
Ile Glu Gly Arg 435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser
Ala Arg Lys Leu Ala Asn 450 455 460Gln Ala Leu Ala Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Leu465 470 475 480Val Leu Gln Cys Ile
Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 485 490 495Ser Glu Asp
Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 500 505 510Ser
Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 515 520
525Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn
530 535 540Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu
Glu Leu545 550 555 560Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys
Lys Tyr Glu Leu Asp 565 570 575Lys Tyr Thr Met Phe His Tyr Leu Arg
Ala Gln Glu Phe Glu His Gly 580 585 590Lys Ser Arg Ile Ala Leu Thr
Asn Ser Val Asn Glu Ala Leu Leu Asn 595 600 605Pro Ser Arg Val Tyr
Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 610 615 620Asn Lys Ala
Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu625 630 635
640Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys
645 650 655Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala
Leu Asn 660 665 670Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly
Ala Leu Ile Phe 675 680 685Ser Gly Ala Val Ile Leu Leu Glu Phe Ile
Pro Glu Ile Ala Ile Pro 690 695 700Val Leu Gly Thr Phe Ala Leu Val
Ser Tyr Ile Ala Asn Lys Val Leu705 710 715 720Thr Val Gln Thr Ile
Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 725 730 735Asp Glu Val
Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 740 745 750Thr
Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 755 760
765Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr
770 775 780Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp
Leu Ser785 790 795 800Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
Ile Asn Ile Asn Lys 805 810 815Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met Asn Ser Met Ile Pro 820 825 830Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala Ser Leu Lys Asp Ala 835 840 845Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val 850 855 860Asp Arg Leu
Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro865 870 875
880Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu
885 890 895Asp602724DNAArtificial SequenceSynthetic 60ggatccatgg
agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca
tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctc tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa
atcagcgcgt 1380aaattagcta accaggcgct agcgggtggt ggtggttctg
gtggtggtgg ttctggtggt 1440ggtggttctg gtggtggtgg ttctgcacta
gtgctgcagt gtatcaaggt taacaactgg 1500gatttattct tcagcccgag
tgaagacaac ttcaccaacg acctgaacaa aggtgaagaa 1560atcacctcag
atactaacat cgaagcagcc gaagaaaaca tctcgctgga cctgatccag
1620cagtactacc tgacctttaa tttcgacaac gagccggaaa acatttctat
cgaaaacctg 1680agctctgata tcatcggcca gctggaactg atgccgaaca
tcgaacgttt cccaaacggt 1740aaaaagtacg agctggacaa atataccatg
ttccactacc tgcgcgcgca ggaatttgaa 1800cacggcaaat cccgtatcgc
actgactaac tccgttaacg aagctctgct caacccgtcc 1860cgtgtataca
ccttcttctc tagcgactac gtgaaaaagg tcaacaaagc gactgaagct
1920gcaatgttct tgggttgggt tgaacagctt gtttatgatt ttaccgacga
gacgtccgaa 1980gtatctacta ccgacaaaat tgcggatatc actatcatca
tcccgtacat cggtccggct 2040ctgaacattg gcaacatgct gtacaaagac
gacttcgttg gcgcactgat cttctccggt 2100gcggtgatcc tgctggagtt
catcccggaa atcgccatcc cggtactggg cacctttgct 2160ctggtttctt
acattgcaaa caaggttctg actgtacaaa ccatcgacaa cgcgctgagc
2220aaacgtaacg aaaaatggga tgaagtttac aaatatatcg tgaccaactg
gctggctaag 2280gttaatactc agatcgacct catccgcaaa aaaatgaaag
aagcactgga aaaccaggcg 2340gaagctacca aggcaatcat taactaccag
tacaaccagt acaccgagga agaaaaaaac 2400aacatcaact tcaacatcga
cgatctgtcc tctaaactga acgaatccat caacaaagct 2460atgatcaaca
tcaacaagtt cctgaaccag tgctctgtaa gctatctgat gaactccatg
2520atcccgtacg gtgttaaacg tctggaggac ttcgatgcgt ctctgaaaga
cgccctgctg 2580aaatacattt acgacaaccg tggcactctg atcggtcagg
ttgatcgtct gaaggacaaa 2640gtgaacaata ccttatcgac cgacatccct
tttcagctca gtaaatatgt cgataaccaa 2700cgccttttgt ccactctaga ctag
272461907PRTArtificial SequenceSynthetic 61Gly Ser Met Glu Phe Val
Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile
Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40 45Glu Arg Asp
Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro Glu
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75
80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu
85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr
Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile
Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val
Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu Leu Asn Leu
Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile Gln Phe Glu
Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu Thr Arg Asn
Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 195 200
205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala
210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala
Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu Glu Leu
Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp Ser Leu
Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile Val Gly
Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310 315
320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp
325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn
Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile
Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe
Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys
Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val
Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg 435 440
445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala Asn
450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly465 470 475 480Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Val
Leu Gln Cys Ile Lys 485 490 495Val Asn Asn Trp Asp Leu Phe Phe Ser
Pro Ser Glu Asp Asn Phe Thr 500 505 510Asn Asp Leu Asn Lys Gly Glu
Glu Ile Thr Ser Asp Thr Asn Ile Glu 515 520 525Ala Ala Glu Glu Asn
Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu 530 535 540Thr Phe Asn
Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu545 550 555
560Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg
565 570 575Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met
Phe His 580 585 590Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser
Arg Ile Ala Leu 595 600 605Thr Asn Ser Val Asn Glu Ala Leu Leu Asn
Pro Ser Arg Val Tyr Thr 610 615 620Phe Phe Ser Ser Asp Tyr Val Lys
Lys Val Asn Lys Ala Thr Glu Ala625 630 635 640Ala Met Phe Leu Gly
Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp 645
650 655Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr
Ile 660 665 670Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn
Met Leu Tyr 675 680 685Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser
Gly Ala Val Ile Leu 690 695 700Leu Glu Phe Ile Pro Glu Ile Ala Ile
Pro Val Leu Gly Thr Phe Ala705 710 715 720Leu Val Ser Tyr Ile Ala
Asn Lys Val Leu Thr Val Gln Thr Ile Asp 725 730 735Asn Ala Leu Ser
Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr 740 745 750Ile Val
Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile 755 760
765Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys
770 775 780Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu
Lys Asn785 790 795 800Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser
Lys Leu Asn Glu Ser 805 810 815Ile Asn Lys Ala Met Ile Asn Ile Asn
Lys Phe Leu Asn Gln Cys Ser 820 825 830Val Ser Tyr Leu Met Asn Ser
Met Ile Pro Tyr Gly Val Lys Arg Leu 835 840 845Glu Asp Phe Asp Ala
Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile Tyr 850 855 860Asp Asn Arg
Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys Asp Lys865 870 875
880Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr
885 890 895Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 900
90562207DNAArtificial SequenceSynthetic 62ggatccacgc acgtcgacgg
catcattacc tccaaaacta aatctgacga tgacgataaa 60tttggcggtt tcacgggcgc
acgcaaatca gcgcgtaaac gtaagaacca ggcgctagcg 120ggcggtggcg
gtagcggcgg tggcggtagc ggcggtggcg gtagcgcact agtgctgcag
180acgcacggtc tagaatgata aaagctt 207632709DNAArtificial
SequenceSynthetic 63ggatccatgg agttcgttaa caaacagttc aactataaag
acccagttaa cggtgttgac 60attgcttaca tcaaaatccc gaacgctggc cagatgcagc
cggtaaaggc attcaaaatc 120cacaacaaaa tctgggttat cccggaacgt
gataccttta ctaacccgga agaaggtgac 180ctgaacccgc caccggaagc
gaaacaggtg ccggtatctt actatgactc cacctacctg 240tctaccgata
acgaaaagga caactacctg aaaggtgtta ctaaactgtt cgagcgtatt
300tactccaccg acctgggccg tatgctgctg actagcatcg ttcgcggtat
cccgttctgg 360ggcggttcta ccatcgatac cgaactgaaa gtaatcgaca
ctaactgcat caacgttatt 420cagccggacg gttcctatcg ttccgaagaa
ctgaacctgg tgatcatcgg cccgtctgct 480gatatcatcc agttcgagtg
taagagcttt ggtcacgaag ttctgaacct cacccgtaac 540ggctacggtt
ccactcagta catccgtttc tctccggact tcaccttcgg ttttgaagaa
600tccctggaag tagacacgaa cccactgctg ggcgctggta aattcgcaac
tgatcctgcg 660gttaccctgg ctcacgaact gattcatgca ggccaccgcc
tgtacggtat cgccatcaat 720ccgaaccgtg tcttcaaagt taacaccaac
gcgtattacg agatgtccgg tctggaagtt 780agcttcgaag aactgcgtac
ttttggcggt cacgacgcta aattcatcga ctctctgcaa 840gaaaacgagt
tccgtctgta ctactataac aagttcaaag atatcgcatc caccctgaac
900aaagcgaaat ccatcgtggg taccactgct tctctccagt acatgaagaa
cgtttttaaa 960gaaaaatacc tgctcagcga agacacctcc ggcaaattct
ctgtagacaa gttgaaattc 1020gataaacttt acaaaatgct gactgaaatt
tacaccgaag acaacttcgt taagttcttt 1080aaagttctga accgcaaaac
ctatctgaac ttcgacaagg cagtattcaa aatcaacatc 1140gtgccgaaag
ttaactacac tatctacgat ggtttcaacc tgcgtaacac caacctggct
1200gctaatttta acggccagaa cacggaaatc aacaacatga acttcacaaa
actgaaaaac 1260ttcactggtc tgttcgagtt ttacaagctg ctgtgcgtcg
acggcatcat tacctccaaa 1320actaaatctg acgatgacga taaatttggc
ggtttcacgg gcgcacgcaa atcagcgcgt 1380aaacgtaaga accaggcgct
agcgggcggt ggcggtagcg gcggtggcgg tagcggcggt 1440ggcggtagcg
cactagtgct gcagtgtatc aaggttaaca actgggattt attcttcagc
1500ccgagtgaag acaacttcac caacgacctg aacaaaggtg aagaaatcac
ctcagatact 1560aacatcgaag cagccgaaga aaacatctcg ctggacctga
tccagcagta ctacctgacc 1620tttaatttcg acaacgagcc ggaaaacatt
tctatcgaaa acctgagctc tgatatcatc 1680ggccagctgg aactgatgcc
gaacatcgaa cgtttcccaa acggtaaaaa gtacgagctg 1740gacaaatata
ccatgttcca ctacctgcgc gcgcaggaat ttgaacacgg caaatcccgt
1800atcgcactga ctaactccgt taacgaagct ctgctcaacc cgtcccgtgt
atacaccttc 1860ttctctagcg actacgtgaa aaaggtcaac aaagcgactg
aagctgcaat gttcttgggt 1920tgggttgaac agcttgttta tgattttacc
gacgagacgt ccgaagtatc tactaccgac 1980aaaattgcgg atatcactat
catcatcccg tacatcggtc cggctctgaa cattggcaac 2040atgctgtaca
aagacgactt cgttggcgca ctgatcttct ccggtgcggt gatcctgctg
2100gagttcatcc cggaaatcgc catcccggta ctgggcacct ttgctctggt
ttcttacatt 2160gcaaacaagg ttctgactgt acaaaccatc gacaacgcgc
tgagcaaacg taacgaaaaa 2220tgggatgaag tttacaaata tatcgtgacc
aactggctgg ctaaggttaa tactcagatc 2280gacctcatcc gcaaaaaaat
gaaagaagca ctggaaaacc aggcggaagc taccaaggca 2340atcattaact
accagtacaa ccagtacacc gaggaagaaa aaaacaacat caacttcaac
2400atcgacgatc tgtcctctaa actgaacgaa tccatcaaca aagctatgat
caacatcaac 2460aagttcctga accagtgctc tgtaagctat ctgatgaact
ccatgatccc gtacggtgtt 2520aaacgtctgg aggacttcga tgcgtctctg
aaagacgccc tgctgaaata catttacgac 2580aaccgtggca ctctgatcgg
tcaggttgat cgtctgaagg acaaagtgaa caatacctta 2640tcgaccgaca
tcccttttca gctcagtaaa tatgtcgata accaacgcct tttgtccact
2700ctagactag 270964902PRTArtificial SequenceSynthetic 64Gly Ser
Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn
Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25
30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro
35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr
Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly
Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg
Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly
Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn
Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu
Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile
Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170
175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro
180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr
Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala
Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His Arg Leu
Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val
Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser
Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe
Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr
Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295
300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410
415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys
420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Asp Asp Asp
Asp Lys 435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys Arg Lys Asn 450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535
540Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile
Ile545 550 555 560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe
Pro Asn Gly Lys 565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe
His Tyr Leu Arg Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg
Ile Ala Leu Thr Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro
Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys
Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp
Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650
655Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile
660 665 670Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp
Phe Val 675 680 685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu
Glu Phe Ile Pro 690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe
Ala Leu Val Ser Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val
Gln Thr Ile Asp Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp
Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys
Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu
Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775
780Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe
Asn785 790 795 800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile
Asn Lys Ala Met 805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys
Ser Val Ser Tyr Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val
Lys Arg Leu Glu Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu
Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln
Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser
Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890
895Leu Leu Ser Thr Leu Asp 90065207DNAArtificial SequenceSynthetic
65ggatccacgc acgtcgacgg catcattacc tccaaaacta aatctctgat agaaggtaga
60tttggcggtt tcacgggcgc acgcaaatca gcgcgtaaac gtaagaacca ggcgctagcg
120ggcggtggcg gtagcggcgg tggcggtagc ggcggtggcg gtagcgcact
agtgctgcag 180acgcacggtc tagaatgata aaagctt 207662742DNAArtificial
SequenceSynthetic 66ggatccgaat tcatgccgat caccatcaac aacttcaact
acagcgatcc ggtggataac 60aaaaacatcc tgtacctgga tacccatctg aataccctgg
cgaacgaacc ggaaaaagcg 120tttcgtatca ccggcaacat ttgggttatt
ccggatcgtt ttagccgtaa cagcaacccg 180aatctgaata aaccgccgcg
tgttaccagc ccgaaaagcg gttattacga tccgaactat 240ctgagcaccg
atagcgataa agataccttc ctgaaagaaa tcatcaaact gttcaaacgc
300atcaacagcc gtgaaattgg cgaagaactg atctatcgcc tgagcaccga
tattccgttt 360ccgggcaaca acaacacccc gatcaacacc tttgatttcg
atgtggattt caacagcgtt 420gatgttaaaa cccgccaggg taacaattgg
gtgaaaaccg gcagcattaa cccgagcgtg 480attattaccg gtccgcgcga
aaacattatt gatccggaaa ccagcacctt taaactgacc 540aacaacacct
ttgcggcgca ggaaggtttt ggcgcgctga gcattattag cattagcccg
600cgctttatgc tgacctatag caacgcgacc aacgatgttg gtgaaggccg
tttcagcaaa 660agcgaatttt gcatggaccc gatcctgatc ctgatgcatg
aactgaacca tgcgatgcat 720aacctgtatg gcatcgcgat tccgaacgat
cagaccatta gcagcgtgac cagcaacatc 780ttttacagcc agtacaacgt
gaaactggaa tatgcggaaa tctatgcgtt tggcggtccg 840accattgatc
tgattccgaa aagcgcgcgc aaatacttcg aagaaaaagc gctggattac
900tatcgcagca ttgcgaaacg tctgaacagc attaccaccg cgaatccgag
cagcttcaac 960aaatatatcg gcgaatataa acagaaactg atccgcaaat
atcgctttgt ggtggaaagc 1020agcggcgaag ttaccgttaa ccgcaataaa
ttcgtggaac tgtacaacga actgacccag 1080atcttcaccg aatttaacta
tgcgaaaatc tataacgtgc agaaccgtaa aatctacctg 1140agcaacgtgt
ataccccggt gaccgcgaat attctggatg ataacgtgta cgatatccag
1200aacggcttta acatcccgaa aagcaacctg aacgttctgt ttatgggcca
gaacctgagc 1260cgtaatccgg cgctgcgtaa agtgaacccg gaaaacatgc
tgtacctgtt caccaaattt 1320tgcgtcgacg gcatcattac ctccaaaact
aaatctctga tagaaggtag atttggcggt 1380ttcacgggcg cacgcaaatc
agcgcgtaaa cgtaagaacc aggcgctagc gggcggtggc 1440ggtagcggcg
gtggcggtag cggcggtggc ggtagcgcac tagtgctgca gtgtcgtgaa
1500ctgctggtga aaaacaccga tctgccgttt attggcgata tcagcgatgt
gaaaaccgat 1560atcttcctgc gcaaagatat caacgaagaa accgaagtga
tctactaccc ggataacgtg 1620agcgttgatc aggtgatcct gagcaaaaac
accagcgaac atggtcagct ggatctgctg 1680tatccgagca ttgatagcga
aagcgaaatt ctgccgggcg aaaaccaggt gttttacgat 1740aaccgtaccc
agaacgtgga ttacctgaac agctattact acctggaaag ccagaaactg
1800agcgataacg tggaagattt tacctttacc cgcagcattg aagaagcgct
ggataacagc 1860gcgaaagttt acacctattt tccgaccctg gcgaacaaag
ttaatgcggg tgttcagggc 1920ggtctgtttc tgatgtgggc gaacgatgtg
gtggaagatt tcaccaccaa catcctgcgt 1980aaagataccc tggataaaat
cagcgatgtt agcgcgatta ttccgtatat tggtccggcg 2040ctgaacatta
gcaatagcgt gcgtcgtggc aattttaccg aagcgtttgc ggttaccggt
2100gtgaccattc tgctggaagc gtttccggaa tttaccattc cggcgctggg
tgcgtttgtg 2160atctatagca aagtgcagga acgcaacgaa atcatcaaaa
ccatcgataa ctgcctggaa 2220cagcgtatta aacgctggaa agatagctat
gaatggatga tgggcacctg gctgagccgt 2280attatcaccc agttcaacaa
catcagctac cagatgtacg atagcctgaa ctatcaggcg 2340ggtgcgatta
aagcgaaaat cgatctggaa tacaaaaaat acagcggcag cgataaagaa
2400aacatcaaaa gccaggttga aaacctgaaa aacagcctgg atgtgaaaat
tagcgaagcg 2460atgaataaca tcaacaaatt catccgcgaa tgcagcgtga
cctacctgtt caaaaacatg 2520ctgccgaaag tgatcgatga actgaacgaa
tttgatcgca acaccaaagc gaaactgatc 2580aacctgatcg atagccacaa
cattattctg gtgggcgaag tggataaact gaaagcgaaa 2640gttaacaaca
gcttccagaa caccatcccg tttaacatct tcagctatac caacaacagc
2700ctgctgaaag atatcatcaa cgaatacttc aatctagact ag
274267913PRTArtificial SequenceSynthetic 67Gly Ser Glu Phe Met Pro
Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp1 5 10 15Pro Val Asp Asn Lys
Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr 20 25 30Leu Ala Asn Glu
Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp 35 40 45Val Ile Pro
Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys 50 55 60Pro Pro
Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr65 70 75
80Leu Ser Thr Asp Ser Asp Lys Asp Thr Phe Leu Lys Glu Ile Ile Lys
85 90 95Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile
Tyr 100 105 110Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn
Thr Pro Ile 115 120 125Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser
Val Asp Val Lys Thr 130 135 140Arg Gln Gly Asn Asn Trp Val Lys Thr
Gly Ser Ile Asn Pro Ser Val145 150 155 160Ile Ile Thr Gly Pro Arg
Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr 165 170 175Phe Lys Leu Thr
Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala 180 185 190Leu Ser
Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn 195 200
205Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys
210 215 220Met Asp Pro Ile Leu Ile Leu Met His Glu Leu Asn His Ala
Met His225 230 235 240Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln
Thr Ile Ser Ser Val 245 250 255Thr Ser Asn Ile Phe Tyr Ser Gln Tyr
Asn Val Lys Leu Glu Tyr Ala 260 265 270Glu Ile Tyr Ala Phe Gly Gly
Pro Thr Ile Asp Leu Ile Pro Lys Ser 275 280 285Ala Arg Lys Tyr Phe
Glu Glu Lys Ala Leu Asp Tyr
Tyr Arg Ser Ile 290 295 300Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala
Asn Pro Ser Ser Phe Asn305 310 315 320Lys Tyr Ile Gly Glu Tyr Lys
Gln Lys Leu Ile Arg Lys Tyr Arg Phe 325 330 335Val Val Glu Ser Ser
Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val 340 345 350Glu Leu Tyr
Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala 355 360 365Lys
Ile Tyr Asn Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr 370 375
380Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile
Gln385 390 395 400Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val
Leu Phe Met Gly 405 410 415Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg
Lys Val Asn Pro Glu Asn 420 425 430Met Leu Tyr Leu Phe Thr Lys Phe
Cys Val Asp Gly Ile Ile Thr Ser 435 440 445Lys Thr Lys Ser Leu Ile
Glu Gly Arg Phe Gly Gly Phe Thr Gly Ala 450 455 460Arg Lys Ser Ala
Arg Lys Arg Lys Asn Gln Ala Leu Ala Gly Gly Gly465 470 475 480Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu 485 490
495Gln Cys Arg Glu Leu Leu Val Lys Asn Thr Asp Leu Pro Phe Ile Gly
500 505 510Asp Ile Ser Asp Val Lys Thr Asp Ile Phe Leu Arg Lys Asp
Ile Asn 515 520 525Glu Glu Thr Glu Val Ile Tyr Tyr Pro Asp Asn Val
Ser Val Asp Gln 530 535 540Val Ile Leu Ser Lys Asn Thr Ser Glu His
Gly Gln Leu Asp Leu Leu545 550 555 560Tyr Pro Ser Ile Asp Ser Glu
Ser Glu Ile Leu Pro Gly Glu Asn Gln 565 570 575Val Phe Tyr Asp Asn
Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr 580 585 590Tyr Tyr Leu
Glu Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr 595 600 605Phe
Thr Arg Ser Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr 610 615
620Thr Tyr Phe Pro Thr Leu Ala Asn Lys Val Asn Ala Gly Val Gln
Gly625 630 635 640Gly Leu Phe Leu Met Trp Ala Asn Asp Val Val Glu
Asp Phe Thr Thr 645 650 655Asn Ile Leu Arg Lys Asp Thr Leu Asp Lys
Ile Ser Asp Val Ser Ala 660 665 670Ile Ile Pro Tyr Ile Gly Pro Ala
Leu Asn Ile Ser Asn Ser Val Arg 675 680 685Arg Gly Asn Phe Thr Glu
Ala Phe Ala Val Thr Gly Val Thr Ile Leu 690 695 700Leu Glu Ala Phe
Pro Glu Phe Thr Ile Pro Ala Leu Gly Ala Phe Val705 710 715 720Ile
Tyr Ser Lys Val Gln Glu Arg Asn Glu Ile Ile Lys Thr Ile Asp 725 730
735Asn Cys Leu Glu Gln Arg Ile Lys Arg Trp Lys Asp Ser Tyr Glu Trp
740 745 750Met Met Gly Thr Trp Leu Ser Arg Ile Ile Thr Gln Phe Asn
Asn Ile 755 760 765Ser Tyr Gln Met Tyr Asp Ser Leu Asn Tyr Gln Ala
Gly Ala Ile Lys 770 775 780Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr
Ser Gly Ser Asp Lys Glu785 790 795 800Asn Ile Lys Ser Gln Val Glu
Asn Leu Lys Asn Ser Leu Asp Val Lys 805 810 815Ile Ser Glu Ala Met
Asn Asn Ile Asn Lys Phe Ile Arg Glu Cys Ser 820 825 830Val Thr Tyr
Leu Phe Lys Asn Met Leu Pro Lys Val Ile Asp Glu Leu 835 840 845Asn
Glu Phe Asp Arg Asn Thr Lys Ala Lys Leu Ile Asn Leu Ile Asp 850 855
860Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Lys Leu Lys Ala
Lys865 870 875 880Val Asn Asn Ser Phe Gln Asn Thr Ile Pro Phe Asn
Ile Phe Ser Tyr 885 890 895Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile
Asn Glu Tyr Phe Asn Leu 900 905 910Asp682673DNAArtificial
SequenceSynthetic 68ggatccatgg agttcgttaa caaacagttc aactataaag
acccagttaa cggtgttgac 60attgcttaca tcaaaatccc gaacgctggc cagatgcagc
cggtaaaggc attcaaaatc 120cacaacaaaa tctgggttat cccggaacgt
gataccttta ctaacccgga agaaggtgac 180ctgaacccgc caccggaagc
gaaacaggtg ccggtatctt actatgactc cacctacctg 240tctaccgata
acgaaaagga caactacctg aaaggtgtta ctaaactgtt cgagcgtatt
300tactccaccg acctgggccg tatgctgctg actagcatcg ttcgcggtat
cccgttctgg 360ggcggttcta ccatcgatac cgaactgaaa gtaatcgaca
ctaactgcat caacgttatt 420cagccggacg gttcctatcg ttccgaagaa
ctgaacctgg tgatcatcgg cccgtctgct 480gatatcatcc agttcgagtg
taagagcttt ggtcacgaag ttctgaacct cacccgtaac 540ggctacggtt
ccactcagta catccgtttc tctccggact tcaccttcgg ttttgaagaa
600tccctggaag tagacacgaa cccactgctg ggcgctggta aattcgcaac
tgatcctgcg 660gttaccctgg ctcacgaact gattcatgca ggccaccgcc
tgtacggtat cgccatcaat 720ccgaaccgtg tcttcaaagt taacaccaac
gcgtattacg agatgtccgg tctggaagtt 780agcttcgaag aactgcgtac
ttttggcggt cacgacgcta aattcatcga ctctctgcaa 840gaaaacgagt
tccgtctgta ctactataac aagttcaaag atatcgcatc caccctgaac
900aaagcgaaat ccatcgtggg taccactgct tctctccagt acatgaagaa
cgtttttaaa 960gaaaaatacc tgctcagcga agacacctcc ggcaaattct
ctgtagacaa gttgaaattc 1020gataaacttt acaaaatgct gactgaaatt
tacaccgaag acaacttcgt taagttcttt 1080aaagttctga accgcaaaac
ctatctgaac ttcgacaagg cagtattcaa aatcaacatc 1140gtgccgaaag
ttaactacac tatctacgat ggtttcaacc tgcgtaacac caacctggct
1200gctaatttta acggccagaa cacggaaatc aacaacatga acttcacaaa
actgaaaaac 1260ttcactggtc tgttcgagtt ttacaagctg ctgtgcgtcg
acggcatcat tacctccaaa 1320actaaatctc tgatagaagg tagatacggt
ggtttcctgg cgctagcggg cggtggcggt 1380agcggcggtg gcggtagcgg
cggtggcggt agcgcactag tgctgcagtg tatcaaggtt 1440aacaactggg
atttattctt cagcccgagt gaagacaact tcaccaacga cctgaacaaa
1500ggtgaagaaa tcacctcaga tactaacatc gaagcagccg aagaaaacat
ctcgctggac 1560ctgatccagc agtactacct gacctttaat ttcgacaacg
agccggaaaa catttctatc 1620gaaaacctga gctctgatat catcggccag
ctggaactga tgccgaacat cgaacgtttc 1680ccaaacggta aaaagtacga
gctggacaaa tataccatgt tccactacct gcgcgcgcag 1740gaatttgaac
acggcaaatc ccgtatcgca ctgactaact ccgttaacga agctctgctc
1800aacccgtccc gtgtatacac cttcttctct agcgactacg tgaaaaaggt
caacaaagcg 1860actgaagctg caatgttctt gggttgggtt gaacagcttg
tttatgattt taccgacgag 1920acgtccgaag tatctactac cgacaaaatt
gcggatatca ctatcatcat cccgtacatc 1980ggtccggctc tgaacattgg
caacatgctg tacaaagacg acttcgttgg cgcactgatc 2040ttctccggtg
cggtgatcct gctggagttc atcccggaaa tcgccatccc ggtactgggc
2100acctttgctc tggtttctta cattgcaaac aaggttctga ctgtacaaac
catcgacaac 2160gcgctgagca aacgtaacga aaaatgggat gaagtttaca
aatatatcgt gaccaactgg 2220ctggctaagg ttaatactca gatcgacctc
atccgcaaaa aaatgaaaga agcactggaa 2280aaccaggcgg aagctaccaa
ggcaatcatt aactaccagt acaaccagta caccgaggaa 2340gaaaaaaaca
acatcaactt caacatcgac gatctgtcct ctaaactgaa cgaatccatc
2400aacaaagcta tgatcaacat caacaagttc ctgaaccagt gctctgtaag
ctatctgatg 2460aactccatga tcccgtacgg tgttaaacgt ctggaggact
tcgatgcgtc tctgaaagac 2520gccctgctga aatacattta cgacaaccgt
ggcactctga tcggtcaggt tgatcgtctg 2580aaggacaaag tgaacaatac
cttatcgacc gacatccctt ttcagctcag taaatatgtc 2640gataaccaac
gccttttgtc cactctagac tag 267369890PRTArtificial SequenceSynthetic
69Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1
5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln
Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
Ile Pro 35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu
Asn Pro Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp
Ser Thr Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu
Lys Gly Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155
160Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn
165 170 175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe
Ser Pro 180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val
Asp Thr Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp
Pro Ala Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His
Arg Leu Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe
Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu
Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala
Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280
285Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser
290 295 300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val
Phe Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly
Lys Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys
Met Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe
Phe Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys
Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr
Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395
400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr
405 410 415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
Leu Cys 420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu
Ile Glu Gly Arg 435 440 445Tyr Gly Gly Phe Leu Ala Leu Ala Gly Gly
Gly Gly Ser Gly Gly Gly 450 455 460Gly Ser Gly Gly Gly Gly Ser Ala
Leu Val Leu Gln Cys Ile Lys Val465 470 475 480Asn Asn Trp Asp Leu
Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn 485 490 495Asp Leu Asn
Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala 500 505 510Ala
Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr 515 520
525Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser
530 535 540Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu
Arg Phe545 550 555 560Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr
Thr Met Phe His Tyr 565 570 575Leu Arg Ala Gln Glu Phe Glu His Gly
Lys Ser Arg Ile Ala Leu Thr 580 585 590Asn Ser Val Asn Glu Ala Leu
Leu Asn Pro Ser Arg Val Tyr Thr Phe 595 600 605Phe Ser Ser Asp Tyr
Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala 610 615 620Met Phe Leu
Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu625 630 635
640Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile
645 650 655Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu
Tyr Lys 660 665 670Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala
Val Ile Leu Leu 675 680 685Glu Phe Ile Pro Glu Ile Ala Ile Pro Val
Leu Gly Thr Phe Ala Leu 690 695 700Val Ser Tyr Ile Ala Asn Lys Val
Leu Thr Val Gln Thr Ile Asp Asn705 710 715 720Ala Leu Ser Lys Arg
Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile 725 730 735Val Thr Asn
Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg 740 745 750Lys
Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala 755 760
765Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn
770 775 780Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu
Ser Ile785 790 795 800Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu
Asn Gln Cys Ser Val 805 810 815Ser Tyr Leu Met Asn Ser Met Ile Pro
Tyr Gly Val Lys Arg Leu Glu 820 825 830Asp Phe Asp Ala Ser Leu Lys
Asp Ala Leu Leu Lys Tyr Ile Tyr Asp 835 840 845Asn Arg Gly Thr Leu
Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val 850 855 860Asn Asn Thr
Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val865 870 875
880Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 885
890702709DNAArtificial SequenceSynthetic 70ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa 1320actaaatctc
tgatagaagg tagatatggc ggtttcacgg gcgcacgcaa atcagcgcgt
1380aaattagcta accaggcgct agcgggcggt ggcggtagcg gcggtggcgg
tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtatc aaggttaaca
actgggattt attcttcagc 1500ccgagtgaag acaacttcac caacgacctg
aacaaaggtg aagaaatcac ctcagatact 1560aacatcgaag cagccgaaga
aaacatctcg ctggacctga tccagcagta ctacctgacc 1620tttaatttcg
acaacgagcc ggaaaacatt tctatcgaaa acctgagctc tgatatcatc
1680ggccagctgg aactgatgcc gaacatcgaa cgtttcccaa acggtaaaaa
gtacgagctg 1740gacaaatata ccatgttcca ctacctgcgc gcgcaggaat
ttgaacacgg caaatcccgt 1800atcgcactga ctaactccgt taacgaagct
ctgctcaacc cgtcccgtgt atacaccttc 1860ttctctagcg actacgtgaa
aaaggtcaac aaagcgactg aagctgcaat gttcttgggt 1920tgggttgaac
agcttgttta tgattttacc gacgagacgt ccgaagtatc tactaccgac
1980aaaattgcgg atatcactat catcatcccg tacatcggtc cggctctgaa
cattggcaac 2040atgctgtaca aagacgactt cgttggcgca ctgatcttct
ccggtgcggt gatcctgctg 2100gagttcatcc cggaaatcgc catcccggta
ctgggcacct ttgctctggt ttcttacatt 2160gcaaacaagg ttctgactgt
acaaaccatc gacaacgcgc tgagcaaacg taacgaaaaa 2220tgggatgaag
tttacaaata tatcgtgacc aactggctgg ctaaggttaa tactcagatc
2280gacctcatcc gcaaaaaaat gaaagaagca ctggaaaacc aggcggaagc
taccaaggca 2340atcattaact accagtacaa ccagtacacc gaggaagaaa
aaaacaacat caacttcaac 2400atcgacgatc tgtcctctaa actgaacgaa
tccatcaaca aagctatgat caacatcaac 2460aagttcctga accagtgctc
tgtaagctat ctgatgaact ccatgatccc gtacggtgtt 2520aaacgtctgg
aggacttcga tgcgtctctg aaagacgccc tgctgaaata catttacgac
2580aaccgtggca ctctgatcgg tcaggttgat cgtctgaagg acaaagtgaa
caatacctta 2640tcgaccgaca tcccttttca gctcagtaaa tatgtcgata
accaacgcct tttgtccact 2700ctagactag 270971902PRTArtificial
SequenceSynthetic 71Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr
Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys Ala Phe Lys Ile His Asn
Lys Ile Trp Val Ile Pro 35
40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr
Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly
Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg
Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly
Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn
Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu
Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile
Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170
175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro
180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr
Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala
Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His Arg Leu
Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val
Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser
Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe
Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr
Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295
300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410
415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys
420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu
Gly Arg 435 440 445Tyr Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys Leu Ala Asn 450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535
540Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile
Ile545 550 555 560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe
Pro Asn Gly Lys 565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe
His Tyr Leu Arg Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg
Ile Ala Leu Thr Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro
Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys
Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp
Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650
655Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile
660 665 670Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp
Phe Val 675 680 685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu
Glu Phe Ile Pro 690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe
Ala Leu Val Ser Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val
Gln Thr Ile Asp Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp
Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys
Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu
Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775
780Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe
Asn785 790 795 800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile
Asn Lys Ala Met 805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys
Ser Val Ser Tyr Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val
Lys Arg Leu Glu Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu
Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln
Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser
Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890
895Leu Leu Ser Thr Leu Asp 900722709DNAArtificial SequenceSynthetic
72ggatccatgg agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac
60attgcttaca tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctc tgatagaagg tagatatggc ggtttcacgg gcgcacgcaa
atcagcgcgt 1380aaacgtaaga accaggcgct agcgggcggt ggcggtagcg
gcggtggcgg tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtatc
aaggttaaca actgggattt attcttcagc 1500ccgagtgaag acaacttcac
caacgacctg aacaaaggtg aagaaatcac ctcagatact 1560aacatcgaag
cagccgaaga aaacatctcg ctggacctga tccagcagta ctacctgacc
1620tttaatttcg acaacgagcc ggaaaacatt tctatcgaaa acctgagctc
tgatatcatc 1680ggccagctgg aactgatgcc gaacatcgaa cgtttcccaa
acggtaaaaa gtacgagctg 1740gacaaatata ccatgttcca ctacctgcgc
gcgcaggaat ttgaacacgg caaatcccgt 1800atcgcactga ctaactccgt
taacgaagct ctgctcaacc cgtcccgtgt atacaccttc 1860ttctctagcg
actacgtgaa aaaggtcaac aaagcgactg aagctgcaat gttcttgggt
1920tgggttgaac agcttgttta tgattttacc gacgagacgt ccgaagtatc
tactaccgac 1980aaaattgcgg atatcactat catcatcccg tacatcggtc
cggctctgaa cattggcaac 2040atgctgtaca aagacgactt cgttggcgca
ctgatcttct ccggtgcggt gatcctgctg 2100gagttcatcc cggaaatcgc
catcccggta ctgggcacct ttgctctggt ttcttacatt 2160gcaaacaagg
ttctgactgt acaaaccatc gacaacgcgc tgagcaaacg taacgaaaaa
2220tgggatgaag tttacaaata tatcgtgacc aactggctgg ctaaggttaa
tactcagatc 2280gacctcatcc gcaaaaaaat gaaagaagca ctggaaaacc
aggcggaagc taccaaggca 2340atcattaact accagtacaa ccagtacacc
gaggaagaaa aaaacaacat caacttcaac 2400atcgacgatc tgtcctctaa
actgaacgaa tccatcaaca aagctatgat caacatcaac 2460aagttcctga
accagtgctc tgtaagctat ctgatgaact ccatgatccc gtacggtgtt
2520aaacgtctgg aggacttcga tgcgtctctg aaagacgccc tgctgaaata
catttacgac 2580aaccgtggca ctctgatcgg tcaggttgat cgtctgaagg
acaaagtgaa caatacctta 2640tcgaccgaca tcccttttca gctcagtaaa
tatgtcgata accaacgcct tttgtccact 2700ctagactag
270973902PRTArtificial SequenceSynthetic 73Gly Ser Met Glu Phe Val
Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile
Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40 45Glu Arg Asp
Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro Glu
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75
80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu
85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr
Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile
Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val
Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu Leu Asn Leu
Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile Gln Phe Glu
Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu Thr Arg Asn
Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 195 200
205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala
210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala
Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu Glu Leu
Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp Ser Leu
Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile Val Gly
Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310 315
320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp
325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn
Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile
Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe
Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys
Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val
Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg 435 440
445Tyr Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Arg Lys Asn
450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu Gln Cys Ile Lys
Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro Ser Glu Asp Asn
Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu Ile Thr Ser Asp
Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile Ser Leu Asp Leu
Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535 540Asn Glu Pro
Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile545 550 555
560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys
565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg
Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr
Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr
Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys Val Asn Lys Ala
Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp Val Glu Gln Leu
Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650 655Ser Thr Thr
Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile 660 665 670Gly
Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val 675 680
685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro
690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser
Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp
Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp Asp Glu Val Tyr
Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys Val Asn Thr Gln
Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu Ala Leu Glu Asn
Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775 780Gln Tyr Asn
Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn785 790 795
800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln Val Asp Arg Leu
Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser Thr Asp Ile Pro
Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890 895Leu Leu Ser
Thr Leu Asp 900742889DNAArtificial SequenceSynthetic 74ggatccttgg
tacgagatga cgttgactat caaattttcc gcgactttgc ggaaaataaa 60ggtaagtttt
tcgtcggcgc cacagacctg tccgtcaaaa ataagagagg ccagaacatc
120ggtaacgcac tgagcaacgt ccctatgatt gattttagtg tagcggacgt
taataaacgg 180attgcaaccg tcgttgatcc gcagtatgct gtcagcgtca
aacatgctaa agcggaagtt 240catacgttct attacgggca atataacggc
cataacgatg tggctgataa agaaaatgaa 300tatcgcgtgg tcgagcagaa
caattacgaa ccgcacaaag cgtggggcgc gagtaattta 360ggccgcctgg
aggactataa catggcccgt ttcaataaat tcgtgaccga ggtagcaccg
420atcgccccca cagatgctgg tgggggcctg gatacctaca aagataaaaa
ccgcttctct 480agcttcgtgc gcattggcgc cggtcgtcag ctcgtgtacg
agaagggtgt ctatcaccag 540gaaggtaatg aaaaggggta cgacctccgt
gatttgtccc aggcgtatcg ctacgctatt 600gccggaaccc cgtataaaga
tattaatatc gatcaaacca tgaataccga aggcctaatt 660ggtttcggga
atcataataa gcaatatagc gcagaagagc taaagcaggc cctcagccaa
720gatgcgttaa ccaattacgg agtgttaggc gatagcggca gtccgctgtt
tgccttcgat 780aaacagaaaa atcaatgggt gtttctgggc acttatgatt
attgggccgg atatggtaaa 840aagagctggc aggaatggaa tatttataaa
aaggaattcg cagacaaaat caagcagcat 900gacaacgcag gtacggtgaa
ggggaacggc gaacatcact ggaagacgac cggcacgaat 960agtcatatcg
gatcgacggc cgttcgcctg gcgaacaatg agggcgatgc aaacaatggg
1020caaaacgtga cctttgagga caacggtacc ctggtcctta accagaacat
aaatcagggc 1080gcgggaggct tgttctttaa aggcgactat actgttaagg
gagcaaacaa tgacatcacc 1140tggttagggg ccggtattga cgttgcggat
ggaaaaaagg tggtttggca ggttaaaaac 1200cctaacgggg accggctggc
aaaaatcggc aaagggacat tggaaattaa tggtaccggt 1260gtgaatcagg
gtcagctgaa agtgggagat gggaccgtga ttctgaacca gaaagcagac
1320gctgacaaaa aggtgcaagc ctttagccaa gtaggaattg ttagtggtcg
tggcacactc 1380gtcttgaact caagcaacca aataaatccg gataacctgt
actttggatt tcgtggcgga 1440cgcctggatg ctaacgggaa tgatctgacc
tttgaacata
tccgtaacgt tgacgagggt 1500gcgcgcatag ttaatcataa tactgaccat
gcatcaacta tcaccttgac cgggaaaagt 1560ctgattacaa acccaaactc
tctgtcagta cattccatcc agaatgatta tgatgaagac 1620gattactcat
actattaccg gccgcgtaga ccaattccac aaggtaaaga tctttattac
1680aaaaattacc gttattacgc attaaaatcc ggagggcggc tgaatgcacc
tatgccggaa 1740aatggcgtgg ccgaaaacaa tgactggatt tttatgggtt
atactcaaga agaggctcgc 1800aaaaatgcaa tgaaccataa aaataaccga
aggatcggtg atttcggcgg atttttcgat 1860gaggaaaatg gtaaaggtca
caatggtgcg ctgaatctaa attttaacgg caaaagtgcc 1920cagaaacgtt
tccttctgac tggtggcgct aatctgaatg gtaaaatcag tgtgacgcag
1980ggtaacgtgc tgctttctgg ccggccaact ccgcatgcac gtgattttgt
aaataaatcg 2040agcgctcgta aagatgcgca tttttctaaa aataacgagg
tcgtgtttga agatgactgg 2100ataaatcgca cctttaaagc ggcagaaatc
gcggttaatc agagtgcgag cttttcatcg 2160ggtaggaatg tatctgatat
tacagcaaac attacagcca ctgataatgc gaaggtcaac 2220ctgggttata
aaaacggtga tgaagtttgt gttcgatcgg attacacggg ctatgttacc
2280tgcaacactg gcaatctgtc tgataaagcg cttaactctt ttgacgccac
gcgcattaac 2340gggaatgtga acctgaacca aaacgctgcc ttggtacttg
gtaaggccgc gttgtggggt 2400aaaattcagg gccagggcaa ctcccgtgtg
tctctgaacc agcactcgaa gtggcacctg 2460acgggggact cgcaggtgca
caacttgtcc ctggccgata gccatattca ccttaacaat 2520gcgtccgatg
cccagtcagc taataaatat catacgatca aaatcaatca cctctctggc
2580aacggtcact ttcactactt aacggattta gcaaaaaact taggggataa
agtcctggta 2640aaagaatcag cgagcggaca ttatcagtta catgtacaga
acaaaacagg cgagccaaat 2700caggaaggcc ttgacttatt tgatgcttca
tcggtacaag atcgttccag actgttcgtt 2760tcactcgcga atcactacgt
tgatctgggt gcgctgcgct atactataaa gacggaaaat 2820ggcataacac
gcctctataa tccctatgcc ggtaacggcc gtccggtgaa acctgctccc
2880tgcgtcgac 2889754296DNAArtificial SequenceSynthetic
75ggatccttgg tacgagatga cgttgactat caaattttcc gcgactttgc ggaaaataaa
60ggtaagtttt tcgtcggcgc cacagacctg tccgtcaaaa ataagagagg ccagaacatc
120ggtaacgcac tgagcaacgt ccctatgatt gattttagtg tagcggacgt
taataaacgg 180attgcaaccg tcgttgatcc gcagtatgct gtcagcgtca
aacatgctaa agcggaagtt 240catacgttct attacgggca atataacggc
cataacgatg tggctgataa agaaaatgaa 300tatcgcgtgg tcgagcagaa
caattacgaa ccgcacaaag cgtggggcgc gagtaattta 360ggccgcctgg
aggactataa catggcccgt ttcaataaat tcgtgaccga ggtagcaccg
420atcgccccca cagatgctgg tgggggcctg gatacctaca aagataaaaa
ccgcttctct 480agcttcgtgc gcattggcgc cggtcgtcag ctcgtgtacg
agaagggtgt ctatcaccag 540gaaggtaatg aaaaggggta cgacctccgt
gatttgtccc aggcgtatcg ctacgctatt 600gccggaaccc cgtataaaga
tattaatatc gatcaaacca tgaataccga aggcctaatt 660ggtttcggga
atcataataa gcaatatagc gcagaagagc taaagcaggc cctcagccaa
720gatgcgttaa ccaattacgg agtgttaggc gatagcggca gtccgctgtt
tgccttcgat 780aaacagaaaa atcaatgggt gtttctgggc acttatgatt
attgggccgg atatggtaaa 840aagagctggc aggaatggaa tatttataaa
aaggaattcg cagacaaaat caagcagcat 900gacaacgcag gtacggtgaa
ggggaacggc gaacatcact ggaagacgac cggcacgaat 960agtcatatcg
gatcgacggc cgttcgcctg gcgaacaatg agggcgatgc aaacaatggg
1020caaaacgtga cctttgagga caacggtacc ctggtcctta accagaacat
aaatcagggc 1080gcgggaggct tgttctttaa aggcgactat actgttaagg
gagcaaacaa tgacatcacc 1140tggttagggg ccggtattga cgttgcggat
ggaaaaaagg tggtttggca ggttaaaaac 1200cctaacgggg accggctggc
aaaaatcggc aaagggacat tggaaattaa tggtaccggt 1260gtgaatcagg
gtcagctgaa agtgggagat gggaccgtga ttctgaacca gaaagcagac
1320gctgacaaaa aggtgcaagc ctttagccaa gtaggaattg ttagtggtcg
tggcacactc 1380gtcttgaact caagcaacca aataaatccg gataacctgt
actttggatt tcgtggcgga 1440cgcctggatg ctaacgggaa tgatctgacc
tttgaacata tccgtaacgt tgacgagggt 1500gcgcgcatag ttaatcataa
tactgaccat gcatcaacta tcaccttgac cgggaaaagt 1560ctgattacaa
acccaaactc tctgtcagta cattccatcc agaatgatta tgatgaagac
1620gattactcat actattaccg gccgcgtaga ccaattccac aaggtaaaga
tctttattac 1680aaaaattacc gttattacgc attaaaatcc ggagggcggc
tgaatgcacc tatgccggaa 1740aatggcgtgg ccgaaaacaa tgactggatt
tttatgggtt atactcaaga agaggctcgc 1800aaaaatgcaa tgaaccataa
aaataaccga aggatcggtg atttcggcgg atttttcgat 1860gaggaaaatg
gtaaaggtca caatggtgcg ctgaatctaa attttaacgg caaaagtgcc
1920cagaaacgtt tccttctgac tggtggcgct aatctgaatg gtaaaatcag
tgtgacgcag 1980ggtaacgtgc tgctttctgg ccggccaact ccgcatgcac
gtgattttgt aaataaatcg 2040agcgctcgta aagatgcgca tttttctaaa
aataacgagg tcgtgtttga agatgactgg 2100ataaatcgca cctttaaagc
ggcagaaatc gcggttaatc agagtgcgag cttttcatcg 2160ggtaggaatg
tatctgatat tacagcaaac attacagcca ctgataatgc gaaggtcaac
2220ctgggttata aaaacggtga tgaagtttgt gttcgatcgg attacacggg
ctatgttacc 2280tgcaacactg gcaatctgtc tgataaagcg cttaactctt
ttgacgccac gcgcattaac 2340gggaatgtga acctgaacca aaacgctgcc
ttggtacttg gtaaggccgc gttgtggggt 2400aaaattcagg gccagggcaa
ctcccgtgtg tctctgaacc agcactcgaa gtggcacctg 2460acgggggact
cgcaggtgca caacttgtcc ctggccgata gccatattca ccttaacaat
2520gcgtccgatg cccagtcagc taataaatat catacgatca aaatcaatca
cctctctggc 2580aacggtcact ttcactactt aacggattta gcaaaaaact
taggggataa agtcctggta 2640aaagaatcag cgagcggaca ttatcagtta
catgtacaga acaaaacagg cgagccaaat 2700caggaaggcc ttgacttatt
tgatgcttca tcggtacaag atcgttccag actgttcgtt 2760tcactcgcga
atcactacgt tgatctgggt gcgctgcgct atactataaa gacggaaaat
2820ggcataacac gcctctataa tccctatgcc ggtaacggcc gtccggtgaa
acctgctccc 2880tgcgtcgacg gcatcattac ctccaaaact aaatctctga
tagaaggtag atttggcggt 2940ttcacgggcg cacgcaaatc agcgcgtaaa
cgtaagaacc aggcgctagc gggcggtggc 3000ggtagcggcg gtggcggtag
cggcggtggc ggtagcgcac tagtgctgca gtgtatcaag 3060gttaacaact
gggatttatt cttcagcccg agtgaagaca acttcaccaa cgacctgaac
3120aaaggtgaag aaatcacctc agatactaac atcgaagcag ccgaagaaaa
catctcgctg 3180gacctgatcc agcagtacta cctgaccttt aatttcgaca
acgagccgga aaacatttct 3240atcgaaaacc tgagctctga tatcatcggc
cagctggaac tgatgccgaa catcgaacgt 3300ttcccaaacg gtaaaaagta
cgagctggac aaatatacca tgttccacta cctgcgcgcg 3360caggaatttg
aacacggcaa atcccgtatc gcactgacta actccgttaa cgaagctctg
3420ctcaacccgt cccgtgtata caccttcttc tctagcgact acgtgaaaaa
ggtcaacaaa 3480gcgactgaag ctgcaatgtt cttgggttgg gttgaacagc
ttgtttatga ttttaccgac 3540gagacgtccg aagtatctac taccgacaaa
attgcggata tcactatcat catcccgtac 3600atcggtccgg ctctgaacat
tggcaacatg ctgtacaaag acgacttcgt tggcgcactg 3660atcttctccg
gtgcggtgat cctgctggag ttcatcccgg aaatcgccat cccggtactg
3720ggcacctttg ctctggtttc ttacattgca aacaaggttc tgactgtaca
aaccatcgac 3780aacgcgctga gcaaacgtaa cgaaaaatgg gatgaagttt
acaaatatat cgtgaccaac 3840tggctggcta aggttaatac tcagatcgac
ctcatccgca aaaaaatgaa agaagcactg 3900gaaaaccagg cggaagctac
caaggcaatc attaactacc agtacaacca gtacaccgag 3960gaagaaaaaa
acaacatcaa cttcaacatc gacgatctgt cctctaaact gaacgaatcc
4020atcaacaaag ctatgatcaa catcaacaag ttcctgaacc agtgctctgt
aagctatctg 4080atgaactcca tgatcccgta cggtgttaaa cgtctggagg
acttcgatgc gtctctgaaa 4140gacgccctgc tgaaatacat ttacgacaac
cgtggcactc tgatcggtca ggttgatcgt 4200ctgaaggaca aagtgaacaa
taccttatcg accgacatcc cttttcagct cagtaaatat 4260gtcgataacc
aacgcctttt gtccactcta gactag 4296761431PRTArtificial
SequenceSynthetic 76Gly Ser Leu Val Arg Asp Asp Val Asp Tyr Gln Ile
Phe Arg Asp Phe1 5 10 15Ala Glu Asn Lys Gly Lys Phe Phe Val Gly Ala
Thr Asp Leu Ser Val 20 25 30Lys Asn Lys Arg Gly Gln Asn Ile Gly Asn
Ala Leu Ser Asn Val Pro 35 40 45Met Ile Asp Phe Ser Val Ala Asp Val
Asn Lys Arg Ile Ala Thr Val 50 55 60Val Asp Pro Gln Tyr Ala Val Ser
Val Lys His Ala Lys Ala Glu Val65 70 75 80His Thr Phe Tyr Tyr Gly
Gln Tyr Asn Gly His Asn Asp Val Ala Asp 85 90 95Lys Glu Asn Glu Tyr
Arg Val Val Glu Gln Asn Asn Tyr Glu Pro His 100 105 110Lys Ala Trp
Gly Ala Ser Asn Leu Gly Arg Leu Glu Asp Tyr Asn Met 115 120 125Ala
Arg Phe Asn Lys Phe Val Thr Glu Val Ala Pro Ile Ala Pro Thr 130 135
140Asp Ala Gly Gly Gly Leu Asp Thr Tyr Lys Asp Lys Asn Arg Phe
Ser145 150 155 160Ser Phe Val Arg Ile Gly Ala Gly Arg Gln Leu Val
Tyr Glu Lys Gly 165 170 175Val Tyr His Gln Glu Gly Asn Glu Lys Gly
Tyr Asp Leu Arg Asp Leu 180 185 190Ser Gln Ala Tyr Arg Tyr Ala Ile
Ala Gly Thr Pro Tyr Lys Asp Ile 195 200 205Asn Ile Asp Gln Thr Met
Asn Thr Glu Gly Leu Ile Gly Phe Gly Asn 210 215 220His Asn Lys Gln
Tyr Ser Ala Glu Glu Leu Lys Gln Ala Leu Ser Gln225 230 235 240Asp
Ala Leu Thr Asn Tyr Gly Val Leu Gly Asp Ser Gly Ser Pro Leu 245 250
255Phe Ala Phe Asp Lys Gln Lys Asn Gln Trp Val Phe Leu Gly Thr Tyr
260 265 270Asp Tyr Trp Ala Gly Tyr Gly Lys Lys Ser Trp Gln Glu Trp
Asn Ile 275 280 285Tyr Lys Lys Glu Phe Ala Asp Lys Ile Lys Gln His
Asp Asn Ala Gly 290 295 300Thr Val Lys Gly Asn Gly Glu His His Trp
Lys Thr Thr Gly Thr Asn305 310 315 320Ser His Ile Gly Ser Thr Ala
Val Arg Leu Ala Asn Asn Glu Gly Asp 325 330 335Ala Asn Asn Gly Gln
Asn Val Thr Phe Glu Asp Asn Gly Thr Leu Val 340 345 350Leu Asn Gln
Asn Ile Asn Gln Gly Ala Gly Gly Leu Phe Phe Lys Gly 355 360 365Asp
Tyr Thr Val Lys Gly Ala Asn Asn Asp Ile Thr Trp Leu Gly Ala 370 375
380Gly Ile Asp Val Ala Asp Gly Lys Lys Val Val Trp Gln Val Lys
Asn385 390 395 400Pro Asn Gly Asp Arg Leu Ala Lys Ile Gly Lys Gly
Thr Leu Glu Ile 405 410 415Asn Gly Thr Gly Val Asn Gln Gly Gln Leu
Lys Val Gly Asp Gly Thr 420 425 430Val Ile Leu Asn Gln Lys Ala Asp
Ala Asp Lys Lys Val Gln Ala Phe 435 440 445Ser Gln Val Gly Ile Val
Ser Gly Arg Gly Thr Leu Val Leu Asn Ser 450 455 460Ser Asn Gln Ile
Asn Pro Asp Asn Leu Tyr Phe Gly Phe Arg Gly Gly465 470 475 480Arg
Leu Asp Ala Asn Gly Asn Asp Leu Thr Phe Glu His Ile Arg Asn 485 490
495Val Asp Glu Gly Ala Arg Ile Val Asn His Asn Thr Asp His Ala Ser
500 505 510Thr Ile Thr Leu Thr Gly Lys Ser Leu Ile Thr Asn Pro Asn
Ser Leu 515 520 525Ser Val His Ser Ile Gln Asn Asp Tyr Asp Glu Asp
Asp Tyr Ser Tyr 530 535 540Tyr Tyr Arg Pro Arg Arg Pro Ile Pro Gln
Gly Lys Asp Leu Tyr Tyr545 550 555 560Lys Asn Tyr Arg Tyr Tyr Ala
Leu Lys Ser Gly Gly Arg Leu Asn Ala 565 570 575Pro Met Pro Glu Asn
Gly Val Ala Glu Asn Asn Asp Trp Ile Phe Met 580 585 590Gly Tyr Thr
Gln Glu Glu Ala Arg Lys Asn Ala Met Asn His Lys Asn 595 600 605Asn
Arg Arg Ile Gly Asp Phe Gly Gly Phe Phe Asp Glu Glu Asn Gly 610 615
620Lys Gly His Asn Gly Ala Leu Asn Leu Asn Phe Asn Gly Lys Ser
Ala625 630 635 640Gln Lys Arg Phe Leu Leu Thr Gly Gly Ala Asn Leu
Asn Gly Lys Ile 645 650 655Ser Val Thr Gln Gly Asn Val Leu Leu Ser
Gly Arg Pro Thr Pro His 660 665 670Ala Arg Asp Phe Val Asn Lys Ser
Ser Ala Arg Lys Asp Ala His Phe 675 680 685Ser Lys Asn Asn Glu Val
Val Phe Glu Asp Asp Trp Ile Asn Arg Thr 690 695 700Phe Lys Ala Ala
Glu Ile Ala Val Asn Gln Ser Ala Ser Phe Ser Ser705 710 715 720Gly
Arg Asn Val Ser Asp Ile Thr Ala Asn Ile Thr Ala Thr Asp Asn 725 730
735Ala Lys Val Asn Leu Gly Tyr Lys Asn Gly Asp Glu Val Cys Val Arg
740 745 750Ser Asp Tyr Thr Gly Tyr Val Thr Cys Asn Thr Gly Asn Leu
Ser Asp 755 760 765Lys Ala Leu Asn Ser Phe Asp Ala Thr Arg Ile Asn
Gly Asn Val Asn 770 775 780Leu Asn Gln Asn Ala Ala Leu Val Leu Gly
Lys Ala Ala Leu Trp Gly785 790 795 800Lys Ile Gln Gly Gln Gly Asn
Ser Arg Val Ser Leu Asn Gln His Ser 805 810 815Lys Trp His Leu Thr
Gly Asp Ser Gln Val His Asn Leu Ser Leu Ala 820 825 830Asp Ser His
Ile His Leu Asn Asn Ala Ser Asp Ala Gln Ser Ala Asn 835 840 845Lys
Tyr His Thr Ile Lys Ile Asn His Leu Ser Gly Asn Gly His Phe 850 855
860His Tyr Leu Thr Asp Leu Ala Lys Asn Leu Gly Asp Lys Val Leu
Val865 870 875 880Lys Glu Ser Ala Ser Gly His Tyr Gln Leu His Val
Gln Asn Lys Thr 885 890 895Gly Glu Pro Asn Gln Glu Gly Leu Asp Leu
Phe Asp Ala Ser Ser Val 900 905 910Gln Asp Arg Ser Arg Leu Phe Val
Ser Leu Ala Asn His Tyr Val Asp 915 920 925Leu Gly Ala Leu Arg Tyr
Thr Ile Lys Thr Glu Asn Gly Ile Thr Arg 930 935 940Leu Tyr Asn Pro
Tyr Ala Gly Asn Gly Arg Pro Val Lys Pro Ala Pro945 950 955 960Cys
Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly 965 970
975Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Arg Lys
980 985 990Asn Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 995 1000 1005Gly Gly Gly Ser Ala Leu Val Leu Gln Cys Ile
Lys Val Asn Asn 1010 1015 1020Trp Asp Leu Phe Phe Ser Pro Ser Glu
Asp Asn Phe Thr Asn Asp 1025 1030 1035Leu Asn Lys Gly Glu Glu Ile
Thr Ser Asp Thr Asn Ile Glu Ala 1040 1045 1050Ala Glu Glu Asn Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu 1055 1060 1065Thr Phe Asn
Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn 1070 1075 1080Leu
Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile 1085 1090
1095Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr
1100 1105 1110Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly
Lys Ser 1115 1120 1125Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala
Leu Leu Asn Pro 1130 1135 1140Ser Arg Val Tyr Thr Phe Phe Ser Ser
Asp Tyr Val Lys Lys Val 1145 1150 1155Asn Lys Ala Thr Glu Ala Ala
Met Phe Leu Gly Trp Val Glu Gln 1160 1165 1170Leu Val Tyr Asp Phe
Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 1175 1180 1185Asp Lys Ile
Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro 1190 1195 1200Ala
Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly 1205 1210
1215Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro
1220 1225 1230Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val
Ser Tyr 1235 1240 1245Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile
Asp Asn Ala Leu 1250 1255 1260Ser Lys Arg Asn Glu Lys Trp Asp Glu
Val Tyr Lys Tyr Ile Val 1265 1270 1275Thr Asn Trp Leu Ala Lys Val
Asn Thr Gln Ile Asp Leu Ile Arg 1280 1285 1290Lys Lys Met Lys Glu
Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys 1295 1300 1305Ala Ile Ile
Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys 1310 1315 1320Asn
Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn 1325 1330
1335Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn
1340 1345 1350Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro
Tyr Gly 1355 1360 1365Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu
Lys Asp Ala Leu 1370 1375 1380Leu Lys Tyr Ile Tyr Asp Asn Arg Gly
Thr Leu Ile Gly Gln Val 1385 1390 1395Asp Arg Leu Lys Asp Lys Val
Asn Asn Thr Leu Ser Thr Asp Ile 1400 1405 1410Pro Phe Gln Leu Ser
Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 1415 1420 1425Thr Leu Asp
1430771357DNAArtificial SequenceSynthetic 77gctagcgggc ggtggcggta
gcggcggtgg cggtagcggc ggtggcggta gcgcactagt 60gctgcagtgt atcaaggtta
acaactggga tttattcttc agcccgagtg aagacaactt 120caccaacgac
ctgaacaaag gtgaagaaat cacctcagat actaacatcg aagcagccga
180agaaaacatc tcgctggacc tgatccagca gtactacctg acctttaatt
tcgacaacga 240gccggaaaac atttctatcg aaaacctgag ctctgatatc
atcggccagc tggaactgat 300gccgaacatc gaacgtttcc caaacggtaa
aaagtacgag ctggacaaat ataccatgtt 360ccactacctg cgcgcgcagg
aatttgaaca cggcaaatcc
cgtatcgcac tgactaactc 420cgttaacgaa gctctgctca acccgtcccg
tgtatacacc ttcttctcta gcgactacgt 480gaaaaaggtc aacaaagcga
ctgaagctgc aatgttcttg ggttgggttg aacagcttgt 540ttatgatttt
accgacgaga cgtccgaagt atctactacc gacaaaattg cggatatcac
600tatcatcatc ccgtacatcg gtccggctct gaacattggc aacatgctgt
acaaagacga 660cttcgttggc gcactgatct tctccggtgc ggtgatcctg
ctggagttca tcccggaaat 720cgccatcccg gtactgggca cctttgctct
ggtttcttac attgcaaaca aggttctgac 780tgtacaaacc atcgacaacg
cgctgagcaa acgtaacgaa aaatgggatg aagtttacaa 840atatatcgtg
accaactggc tggctaaggt taatactcag atcgacctca tccgcaaaaa
900aatgaaagaa gcactggaaa accaggcgga agctaccaag gcaatcatta
actaccagta 960caaccagtac accgaggaag aaaaaaacaa catcaacttc
aacatcgacg atctgtcctc 1020taaactgaac gaatccatca acaaagctat
gatcaacatc aacaagttcc tgaaccagtg 1080ctctgtaagc tatctgatga
actccatgat cccgtacggt gttaaacgtc tggaggactt 1140cgatgcgtct
ctgaaagacg ccctgctgaa atacatttac gacaaccgtg gcactctgat
1200cggtcaggtt gatcgtctga aggacaaagt gaacaatacc ttatcgaccg
acatcccttt 1260tcagctcagt aaatatgtcg ataaccaacg ccttttgtcc
actctagaaa tagaaggtag 1320aagtgggcac catcaccatc accattaatg aaagctt
1357782745DNAArtificial SequenceSynthetic 78ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa 1320actaaatctc
tgatagaagg tagatttggc ggtttcacgg gcgcacgcaa atcagcgcgt
1380aaacgtaaga accaggcgct agcgggcggt ggcggtagcg gcggtggcgg
tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtatc aaggttaaca
actgggattt attcttcagc 1500ccgagtgaag acaacttcac caacgacctg
aacaaaggtg aagaaatcac ctcagatact 1560aacatcgaag cagccgaaga
aaacatctcg ctggacctga tccagcagta ctacctgacc 1620tttaatttcg
acaacgagcc ggaaaacatt tctatcgaaa acctgagctc tgatatcatc
1680ggccagctgg aactgatgcc gaacatcgaa cgtttcccaa acggtaaaaa
gtacgagctg 1740gacaaatata ccatgttcca ctacctgcgc gcgcaggaat
ttgaacacgg caaatcccgt 1800atcgcactga ctaactccgt taacgaagct
ctgctcaacc cgtcccgtgt atacaccttc 1860ttctctagcg actacgtgaa
aaaggtcaac aaagcgactg aagctgcaat gttcttgggt 1920tgggttgaac
agcttgttta tgattttacc gacgagacgt ccgaagtatc tactaccgac
1980aaaattgcgg atatcactat catcatcccg tacatcggtc cggctctgaa
cattggcaac 2040atgctgtaca aagacgactt cgttggcgca ctgatcttct
ccggtgcggt gatcctgctg 2100gagttcatcc cggaaatcgc catcccggta
ctgggcacct ttgctctggt ttcttacatt 2160gcaaacaagg ttctgactgt
acaaaccatc gacaacgcgc tgagcaaacg taacgaaaaa 2220tgggatgaag
tttacaaata tatcgtgacc aactggctgg ctaaggttaa tactcagatc
2280gacctcatcc gcaaaaaaat gaaagaagca ctggaaaacc aggcggaagc
taccaaggca 2340atcattaact accagtacaa ccagtacacc gaggaagaaa
aaaacaacat caacttcaac 2400atcgacgatc tgtcctctaa actgaacgaa
tccatcaaca aagctatgat caacatcaac 2460aagttcctga accagtgctc
tgtaagctat ctgatgaact ccatgatccc gtacggtgtt 2520aaacgtctgg
aggacttcga tgcgtctctg aaagacgccc tgctgaaata catttacgac
2580aaccgtggca ctctgatcgg tcaggttgat cgtctgaagg acaaagtgaa
caatacctta 2640tcgaccgaca tcccttttca gctcagtaaa tatgtcgata
accaacgcct tttgtccact 2700ctagaaatag aaggtagaag tgggcaccat
caccatcacc attaa 274579914PRTArtificial SequenceSynthetic 79Gly Ser
Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn
Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25
30Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro
35 40 45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
Pro 50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr
Tyr Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly
Val Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg
Met Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly
Gly Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn
Cys Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu
Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile
Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170
175Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro
180 185 190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr
Asn Pro 195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala
Val Thr Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His Arg Leu
Tyr Gly Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val
Asn Thr Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser
Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe
Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr
Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295
300Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
Lys305 310 315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410
415Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys
420 425 430Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu
Gly Arg 435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys Arg Lys Asn 450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535
540Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile
Ile545 550 555 560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe
Pro Asn Gly Lys 565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe
His Tyr Leu Arg Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg
Ile Ala Leu Thr Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro
Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys
Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp
Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650
655Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile
660 665 670Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp
Phe Val 675 680 685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu
Glu Phe Ile Pro 690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe
Ala Leu Val Ser Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val
Gln Thr Ile Asp Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp
Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys
Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu
Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775
780Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe
Asn785 790 795 800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile
Asn Lys Ala Met 805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys
Ser Val Ser Tyr Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val
Lys Arg Leu Glu Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu
Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln
Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser
Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890
895Leu Leu Ser Thr Leu Glu Ile Glu Gly Arg Ser Gly His His His His
900 905 910His His80619DNAArtificial SequenceSynthetic 80gctagcgggc
ggtggcggta gcggcggtgg cggtagcggc ggtggcggta gcgcactagt 60gctgcagtgt
atcaatctgg attgggacgt aatccgtgat aagaccaaaa caaaaatcga
120gtctttgaaa gaacacggcc cgatcaaaaa taagatgtct gaatcaccca
ataaaactgt 180ttcggaggaa aaagcgaaac agtatttgga agagtttcat
caaaccgcgc ttgaacatcc 240ggagctcagt gaactgaaaa cagtgacggg
aacgaatcct gtttttgcag gcgcaaacta 300tgcggcttgg gccgtgaatg
ttgcccaagt aattgatagt gagaccgcag acaacctgga 360aaagacgacc
gcagcgttaa gcattttacc ggggattggt tccgtgatgg gtatagcgga
420tggagcggtc caccataaca ctgaggaaat tgtcgcccag tcaatcgctc
tgagttccct 480gatggttgca caggctatcc cactcgtggg ggaactggtt
gacataggtt tcgccgccta 540caacttcgta gaaagcatta ttaatctttt
tcaggtggtg cataacagct acaaccgccc 600tctagaatga taaaagctt
619811971DNAArtificial SequenceSynthetic 81ggatccatgg agttcgttaa
caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca tcaaaatccc
gaacgctggc cagatgcagc cggtaaaggc attcaaaatc 120cacaacaaaa
tctgggttat cccggaacgt gataccttta ctaacccgga agaaggtgac
180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt actatgactc
cacctacctg 240tctaccgata acgaaaagga caactacctg aaaggtgtta
ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg tatgctgctg
actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta ccatcgatac
cgaactgaaa gtaatcgaca ctaactgcat caacgttatt 420cagccggacg
gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg cccgtctgct
480gatatcatcc agttcgagtg taagagcttt ggtcacgaag ttctgaacct
cacccgtaac 540ggctacggtt ccactcagta catccgtttc tctccggact
tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa cccactgctg
ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg ctcacgaact
gattcatgca ggccaccgcc tgtacggtat cgccatcaat 720ccgaaccgtg
tcttcaaagt taacaccaac gcgtattacg agatgtccgg tctggaagtt
780agcttcgaag aactgcgtac ttttggcggt cacgacgcta aattcatcga
ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac aagttcaaag
atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg taccactgct
tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc tgctcagcga
agacacctcc ggcaaattct ctgtagacaa gttgaaattc 1020gataaacttt
acaaaatgct gactgaaatt tacaccgaag acaacttcgt taagttcttt
1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg cagtattcaa
aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat ggtttcaacc
tgcgtaacac caacctggct 1200gctaatttta acggccagaa cacggaaatc
aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc tgttcgagtt
ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa 1320actaaatctc
tgatagaagg tagatacggt ggtttcctgg cgctagcggg cggtggcggt
1380agcggcggtg gcggtagcgg cggtggcggt agcgcactag tgctgcagtg
tatcaatctg 1440gattgggacg taatccgtga taagaccaaa acaaaaatcg
agtctttgaa agaacacggc 1500ccgatcaaaa ataagatgtc tgaatcaccc
aataaaactg tttcggagga aaaagcgaaa 1560cagtatttgg aagagtttca
tcaaaccgcg cttgaacatc cggagctcag tgaactgaaa 1620acagtgacgg
gaacgaatcc tgtttttgca ggcgcaaact atgcggcttg ggccgtgaat
1680gttgcccaag taattgatag tgagaccgca gacaacctgg aaaagacgac
cgcagcgtta 1740agcattttac cggggattgg ttccgtgatg ggtatagcgg
atggagcggt ccaccataac 1800actgaggaaa ttgtcgccca gtcaatcgct
ctgagttccc tgatggttgc acaggctatc 1860ccactcgtgg gggaactggt
tgacataggt ttcgccgcct acaacttcgt agaaagcatt 1920attaatcttt
ttcaggtggt gcataacagc tacaaccgcc ctctagaatg a
197182656PRTArtificial SequenceSynthetic 82Gly Ser Met Glu Phe Val
Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile
Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40 45Glu Arg Asp
Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro Glu
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75
80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu
85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr
Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile
Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val
Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu Leu Asn Leu
Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile Gln Phe Glu
Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu Thr Arg Asn
Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 195 200
205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala
210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala
Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu Glu Leu
Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp Ser Leu
Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile Val Gly
Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310 315
320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp
325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn
Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile
Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe
Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys
Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val
Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg 435 440
445Tyr Gly Gly Phe Leu Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly
450 455 460Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu Gln Cys Ile
Asn Leu465 470 475 480Asp Trp
Asp Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu 485 490
495Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys
500 505 510Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe
His Gln 515 520 525Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu Lys
Thr Val Thr Gly 530 535 540Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr
Ala Ala Trp Ala Val Asn545 550 555 560Val Ala Gln Val Ile Asp Ser
Glu Thr Ala Asp Asn Leu Glu Lys Thr 565 570 575Thr Ala Ala Leu Ser
Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile 580 585 590Ala Asp Gly
Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser 595 600 605Ile
Ala Leu Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly 610 615
620Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser
Ile625 630 635 640Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr Asn
Arg Pro Leu Glu 645 650 655831329DNAArtificial SequenceSynthetic
83ggatccatgc ctattactat taacaatttt cgttatagcg atcccgtcaa caatgacacc
60attatcatga tggaaccgcc atattgcaaa ggactggaca tttactataa agccttcaag
120attactgacc gcatttggat tgttccagag cgttacgagt tcgggacgaa
accagaagat 180tttaacccgc cttcatcgct gatcgaagga gcatcagagt
attacgatcc gaactatctg 240cgtacggaca gcgataaaga ccgcttctta
cagaccatgg tcaaactttt taaccgtatt 300aagaacaatg tggccggaga
agcactcttg gataagatta tcaacgcgat tccatacctg 360ggcaattctt
acagcctgct ggataaattt gacacaaata gtaattcagt cagctttaac
420ctgttagaac aagatccgag tggcgcaacc acgaagtctg ccatgctgac
aaatctgatc 480atttttggtc caggtcctgt actgaataaa aatgaagtac
gcggcatcgt tctccgcgtg 540gacaataaga actacttccc atgccgtgac
ggcttcggtt cgatcatgca gatggctttc 600tgtccggagt acgttccgac
gtttgataat gttattgaga atatcacgag tttaacaatc 660ggtaagtcaa
aatattttca agatccggcc cttctcctta tgcatgaact gattcacgtg
720ctgcacggct tatatggtat gcaagtgtcc tcgcatgaaa tcattccgtc
caaacaggaa 780atttatatgc agcataccta cccgatttca gctgaagagt
tgtttacgtt tggtggccag 840gacgcgaatt tgatctccat cgacatcaaa
aacgatctgt atgagaaaac attaaatgac 900tataaagcga ttgcgaacaa
actgtctcag gtgactagct gcaacgatcc taacattgat 960attgattcct
acaaacaaat ttatcaacag aaataccagt tcgataaaga cagcaatggt
1020cagtatatcg taaacgaaga taaatttcag atcctgtata acagcattat
gtatggcttt 1080accgaaattg agttggggaa gaaatttaac attaaaaccc
gtctgtctta ttttagtatg 1140aaccatgatc cggtgaaaat ccccaatctg
cttgatgata ccatttataa tgataccgaa 1200gggttcaaca ttgaatctaa
ggatctgaaa tccgaataca aaggccaaaa tatgcgtgtt 1260aatactaacg
ctttccgtaa tgttgatggt agtggactcg tctcgaaact gattgggttg
1320tgtgtcgac 1329842736DNAArtificial SequenceSynthetic
84ggatccatgc ctattactat taacaatttt cgttatagcg atcccgtcaa caatgacacc
60attatcatga tggaaccgcc atattgcaaa ggactggaca tttactataa agccttcaag
120attactgacc gcatttggat tgttccagag cgttacgagt tcgggacgaa
accagaagat 180tttaacccgc cttcatcgct gatcgaagga gcatcagagt
attacgatcc gaactatctg 240cgtacggaca gcgataaaga ccgcttctta
cagaccatgg tcaaactttt taaccgtatt 300aagaacaatg tggccggaga
agcactcttg gataagatta tcaacgcgat tccatacctg 360ggcaattctt
acagcctgct ggataaattt gacacaaata gtaattcagt cagctttaac
420ctgttagaac aagatccgag tggcgcaacc acgaagtctg ccatgctgac
aaatctgatc 480atttttggtc caggtcctgt actgaataaa aatgaagtac
gcggcatcgt tctccgcgtg 540gacaataaga actacttccc atgccgtgac
ggcttcggtt cgatcatgca gatggctttc 600tgtccggagt acgttccgac
gtttgataat gttattgaga atatcacgag tttaacaatc 660ggtaagtcaa
aatattttca agatccggcc cttctcctta tgcatgaact gattcacgtg
720ctgcacggct tatatggtat gcaagtgtcc tcgcatgaaa tcattccgtc
caaacaggaa 780atttatatgc agcataccta cccgatttca gctgaagagt
tgtttacgtt tggtggccag 840gacgcgaatt tgatctccat cgacatcaaa
aacgatctgt atgagaaaac attaaatgac 900tataaagcga ttgcgaacaa
actgtctcag gtgactagct gcaacgatcc taacattgat 960attgattcct
acaaacaaat ttatcaacag aaataccagt tcgataaaga cagcaatggt
1020cagtatatcg taaacgaaga taaatttcag atcctgtata acagcattat
gtatggcttt 1080accgaaattg agttggggaa gaaatttaac attaaaaccc
gtctgtctta ttttagtatg 1140aaccatgatc cggtgaaaat ccccaatctg
cttgatgata ccatttataa tgataccgaa 1200gggttcaaca ttgaatctaa
ggatctgaaa tccgaataca aaggccaaaa tatgcgtgtt 1260aatactaacg
ctttccgtaa tgttgatggt agtggactcg tctcgaaact gattgggttg
1320tgtgtcgacg gcatcattac ctccaaaact aaatctctga tagaaggtag
atttggcggt 1380ttcacgggcg cacgcaaatc agcgcgtaaa cgtaagaacc
aggcgctagc gggcggtggc 1440ggtagcggcg gtggcggtag cggcggtggc
ggtagcgcac tagtgctgca gtgtatcaag 1500gttaacaact gggatttatt
cttcagcccg agtgaagaca acttcaccaa cgacctgaac 1560aaaggtgaag
aaatcacctc agatactaac atcgaagcag ccgaagaaaa catctcgctg
1620gacctgatcc agcagtacta cctgaccttt aatttcgaca acgagccgga
aaacatttct 1680atcgaaaacc tgagctctga tatcatcggc cagctggaac
tgatgccgaa catcgaacgt 1740ttcccaaacg gtaaaaagta cgagctggac
aaatatacca tgttccacta cctgcgcgcg 1800caggaatttg aacacggcaa
atcccgtatc gcactgacta actccgttaa cgaagctctg 1860ctcaacccgt
cccgtgtata caccttcttc tctagcgact acgtgaaaaa ggtcaacaaa
1920gcgactgaag ctgcaatgtt cttgggttgg gttgaacagc ttgtttatga
ttttaccgac 1980gagacgtccg aagtatctac taccgacaaa attgcggata
tcactatcat catcccgtac 2040atcggtccgg ctctgaacat tggcaacatg
ctgtacaaag acgacttcgt tggcgcactg 2100atcttctccg gtgcggtgat
cctgctggag ttcatcccgg aaatcgccat cccggtactg 2160ggcacctttg
ctctggtttc ttacattgca aacaaggttc tgactgtaca aaccatcgac
2220aacgcgctga gcaaacgtaa cgaaaaatgg gatgaagttt acaaatatat
cgtgaccaac 2280tggctggcta aggttaatac tcagatcgac ctcatccgca
aaaaaatgaa agaagcactg 2340gaaaaccagg cggaagctac caaggcaatc
attaactacc agtacaacca gtacaccgag 2400gaagaaaaaa acaacatcaa
cttcaacatc gacgatctgt cctctaaact gaacgaatcc 2460atcaacaaag
ctatgatcaa catcaacaag ttcctgaacc agtgctctgt aagctatctg
2520atgaactcca tgatcccgta cggtgttaaa cgtctggagg acttcgatgc
gtctctgaaa 2580gacgccctgc tgaaatacat ttacgacaac cgtggcactc
tgatcggtca ggttgatcgt 2640ctgaaggaca aagtgaacaa taccttatcg
accgacatcc cttttcagct cagtaaatat 2700gtcgataacc aacgcctttt
gtccactcta gactag 273685911PRTArtificial SequenceSynthetic 85Gly
Ser Met Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val1 5 10
15Asn Asn Asp Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu
20 25 30Asp Ile Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile
Val 35 40 45Pro Glu Arg Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn
Pro Pro 50 55 60Ser Ser Leu Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro
Asn Tyr Leu65 70 75 80Arg Thr Asp Ser Asp Lys Asp Arg Phe Leu Gln
Thr Met Val Lys Leu 85 90 95Phe Asn Arg Ile Lys Asn Asn Val Ala Gly
Glu Ala Leu Leu Asp Lys 100 105 110Ile Ile Asn Ala Ile Pro Tyr Leu
Gly Asn Ser Tyr Ser Leu Leu Asp 115 120 125Lys Phe Asp Thr Asn Ser
Asn Ser Val Ser Phe Asn Leu Leu Glu Gln 130 135 140Asp Pro Ser Gly
Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile145 150 155 160Ile
Phe Gly Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile 165 170
175Val Leu Arg Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe
180 185 190Gly Ser Ile Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro
Thr Phe 195 200 205Asp Asn Val Ile Glu Asn Ile Thr Ser Leu Thr Ile
Gly Lys Ser Lys 210 215 220Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met
His Glu Leu Ile His Val225 230 235 240Leu His Gly Leu Tyr Gly Met
Gln Val Ser Ser His Glu Ile Ile Pro 245 250 255Ser Lys Gln Glu Ile
Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu 260 265 270Glu Leu Phe
Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp 275 280 285Ile
Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile 290 295
300Ala Asn Lys Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile
Asp305 310 315 320Ile Asp Ser Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr
Gln Phe Asp Lys 325 330 335Asp Ser Asn Gly Gln Tyr Ile Val Asn Glu
Asp Lys Phe Gln Ile Leu 340 345 350Tyr Asn Ser Ile Met Tyr Gly Phe
Thr Glu Ile Glu Leu Gly Lys Lys 355 360 365Phe Asn Ile Lys Thr Arg
Leu Ser Tyr Phe Ser Met Asn His Asp Pro 370 375 380Val Lys Ile Pro
Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu385 390 395 400Gly
Phe Asn Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln 405 410
415Asn Met Arg Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly
420 425 430Leu Val Ser Lys Leu Ile Gly Leu Cys Val Asp Gly Ile Ile
Thr Ser 435 440 445Lys Thr Lys Ser Leu Ile Glu Gly Arg Phe Gly Gly
Phe Thr Gly Ala 450 455 460Arg Lys Ser Ala Arg Lys Arg Lys Asn Gln
Ala Leu Ala Gly Gly Gly465 470 475 480Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ala Leu Val Leu 485 490 495Gln Cys Ile Lys Val
Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu 500 505 510Asp Asn Phe
Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp 515 520 525Thr
Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln 530 535
540Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile
Ser545 550 555 560Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu
Glu Leu Met Pro 565 570 575Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys
Tyr Glu Leu Asp Lys Tyr 580 585 590Thr Met Phe His Tyr Leu Arg Ala
Gln Glu Phe Glu His Gly Lys Ser 595 600 605Arg Ile Ala Leu Thr Asn
Ser Val Asn Glu Ala Leu Leu Asn Pro Ser 610 615 620Arg Val Tyr Thr
Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys625 630 635 640Ala
Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr 645 650
655Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala
660 665 670Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn
Ile Gly 675 680 685Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu
Ile Phe Ser Gly 690 695 700Ala Val Ile Leu Leu Glu Phe Ile Pro Glu
Ile Ala Ile Pro Val Leu705 710 715 720Gly Thr Phe Ala Leu Val Ser
Tyr Ile Ala Asn Lys Val Leu Thr Val 725 730 735Gln Thr Ile Asp Asn
Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu 740 745 750Val Tyr Lys
Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln 755 760 765Ile
Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala 770 775
780Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr
Glu785 790 795 800Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp
Leu Ser Ser Lys 805 810 815Leu Asn Glu Ser Ile Asn Lys Ala Met Ile
Asn Ile Asn Lys Phe Leu 820 825 830Asn Gln Cys Ser Val Ser Tyr Leu
Met Asn Ser Met Ile Pro Tyr Gly 835 840 845Val Lys Arg Leu Glu Asp
Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu 850 855 860Lys Tyr Ile Tyr
Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg865 870 875 880Leu
Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln 885 890
895Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 900
905 91086180DNAArtificial SequenceSynthetic 86ggatccacgc acgtcgacgc
gattgatggt cgttttggcg gtttcacggg cgcacgcaaa 60tcagcgcgta aacgtaagaa
ccaggcgcta gcgggcggtg gcggtagcgg cggtggcggt 120agcggcggtg
gcggtagcgc actagtgctg cagacgcacg gtctagaatg ataaaagctt
180872715DNAArtificial SequenceSynthetic 87ggatccgaat tcatgccgat
caccatcaac aacttcaact acagcgatcc ggtggataac 60aaaaacatcc tgtacctgga
tacccatctg aataccctgg cgaacgaacc ggaaaaagcg 120tttcgtatca
ccggcaacat ttgggttatt ccggatcgtt ttagccgtaa cagcaacccg
180aatctgaata aaccgccgcg tgttaccagc ccgaaaagcg gttattacga
tccgaactat 240ctgagcaccg atagcgataa agataccttc ctgaaagaaa
tcatcaaact gttcaaacgc 300atcaacagcc gtgaaattgg cgaagaactg
atctatcgcc tgagcaccga tattccgttt 360ccgggcaaca acaacacccc
gatcaacacc tttgatttcg atgtggattt caacagcgtt 420gatgttaaaa
cccgccaggg taacaattgg gtgaaaaccg gcagcattaa cccgagcgtg
480attattaccg gtccgcgcga aaacattatt gatccggaaa ccagcacctt
taaactgacc 540aacaacacct ttgcggcgca ggaaggtttt ggcgcgctga
gcattattag cattagcccg 600cgctttatgc tgacctatag caacgcgacc
aacgatgttg gtgaaggccg tttcagcaaa 660agcgaatttt gcatggaccc
gatcctgatc ctgatgcatg aactgaacca tgcgatgcat 720aacctgtatg
gcatcgcgat tccgaacgat cagaccatta gcagcgtgac cagcaacatc
780ttttacagcc agtacaacgt gaaactggaa tatgcggaaa tctatgcgtt
tggcggtccg 840accattgatc tgattccgaa aagcgcgcgc aaatacttcg
aagaaaaagc gctggattac 900tatcgcagca ttgcgaaacg tctgaacagc
attaccaccg cgaatccgag cagcttcaac 960aaatatatcg gcgaatataa
acagaaactg atccgcaaat atcgctttgt ggtggaaagc 1020agcggcgaag
ttaccgttaa ccgcaataaa ttcgtggaac tgtacaacga actgacccag
1080atcttcaccg aatttaacta tgcgaaaatc tataacgtgc agaaccgtaa
aatctacctg 1140agcaacgtgt ataccccggt gaccgcgaat attctggatg
ataacgtgta cgatatccag 1200aacggcttta acatcccgaa aagcaacctg
aacgttctgt ttatgggcca gaacctgagc 1260cgtaatccgg cgctgcgtaa
agtgaacccg gaaaacatgc tgtacctgtt caccaaattt 1320tgcgtcgacg
cgattgatgg tcgttttggc ggtttcacgg gcgcacgcaa atcagcgcgt
1380aaacgtaaga accaggcgct agcgggcggt ggcggtagcg gcggtggcgg
tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtcgt gaactgctgg
tgaaaaacac cgatctgccg 1500tttattggcg atatcagcga tgtgaaaacc
gatatcttcc tgcgcaaaga tatcaacgaa 1560gaaaccgaag tgatctacta
cccggataac gtgagcgttg atcaggtgat cctgagcaaa 1620aacaccagcg
aacatggtca gctggatctg ctgtatccga gcattgatag cgaaagcgaa
1680attctgccgg gcgaaaacca ggtgttttac gataaccgta cccagaacgt
ggattacctg 1740aacagctatt actacctgga aagccagaaa ctgagcgata
acgtggaaga ttttaccttt 1800acccgcagca ttgaagaagc gctggataac
agcgcgaaag tttacaccta ttttccgacc 1860ctggcgaaca aagttaatgc
gggtgttcag ggcggtctgt ttctgatgtg ggcgaacgat 1920gtggtggaag
atttcaccac caacatcctg cgtaaagata ccctggataa aatcagcgat
1980gttagcgcga ttattccgta tattggtccg gcgctgaaca ttagcaatag
cgtgcgtcgt 2040ggcaatttta ccgaagcgtt tgcggttacc ggtgtgacca
ttctgctgga agcgtttccg 2100gaatttacca ttccggcgct gggtgcgttt
gtgatctata gcaaagtgca ggaacgcaac 2160gaaatcatca aaaccatcga
taactgcctg gaacagcgta ttaaacgctg gaaagatagc 2220tatgaatgga
tgatgggcac ctggctgagc cgtattatca cccagttcaa caacatcagc
2280taccagatgt acgatagcct gaactatcag gcgggtgcga ttaaagcgaa
aatcgatctg 2340gaatacaaaa aatacagcgg cagcgataaa gaaaacatca
aaagccaggt tgaaaacctg 2400aaaaacagcc tggatgtgaa aattagcgaa
gcgatgaata acatcaacaa attcatccgc 2460gaatgcagcg tgacctacct
gttcaaaaac atgctgccga aagtgatcga tgaactgaac 2520gaatttgatc
gcaacaccaa agcgaaactg atcaacctga tcgatagcca caacattatt
2580ctggtgggcg aagtggataa actgaaagcg aaagttaaca acagcttcca
gaacaccatc 2640ccgtttaaca tcttcagcta taccaacaac agcctgctga
aagatatcat caacgaatac 2700ttcaatctag actag 271588904PRTArtificial
SequenceSynthetic 88Gly Ser Glu Phe Met Pro Ile Thr Ile Asn Asn Phe
Asn Tyr Ser Asp1 5 10 15Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp
Thr His Leu Asn Thr 20 25 30Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg
Ile Thr Gly Asn Ile Trp 35 40 45Val Ile Pro Asp Arg Phe Ser Arg Asn
Ser Asn Pro Asn Leu Asn Lys 50 55 60Pro Pro Arg Val Thr Ser Pro Lys
Ser Gly Tyr Tyr Asp Pro Asn Tyr65 70 75 80Leu Ser Thr Asp Ser Asp
Lys Asp Thr Phe Leu Lys Glu Ile Ile Lys 85 90 95Leu Phe Lys Arg Ile
Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr 100 105 110Arg Leu Ser
Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile 115 120 125Asn
Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr 130 135
140Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser
Val145 150 155 160Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro
Glu Thr Ser Thr 165 170 175Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala
Gln Glu Gly Phe Gly Ala
180 185 190Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr
Ser Asn 195 200 205Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys
Ser Glu Phe Cys 210 215 220Met Asp Pro Ile Leu Ile Leu Met His Glu
Leu Asn His Ala Met His225 230 235 240Asn Leu Tyr Gly Ile Ala Ile
Pro Asn Asp Gln Thr Ile Ser Ser Val 245 250 255Thr Ser Asn Ile Phe
Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala 260 265 270Glu Ile Tyr
Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser 275 280 285Ala
Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile 290 295
300Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe
Asn305 310 315 320Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg
Lys Tyr Arg Phe 325 330 335Val Val Glu Ser Ser Gly Glu Val Thr Val
Asn Arg Asn Lys Phe Val 340 345 350Glu Leu Tyr Asn Glu Leu Thr Gln
Ile Phe Thr Glu Phe Asn Tyr Ala 355 360 365Lys Ile Tyr Asn Val Gln
Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr 370 375 380Thr Pro Val Thr
Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln385 390 395 400Asn
Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly 405 410
415Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn
420 425 430Met Leu Tyr Leu Phe Thr Lys Phe Cys Val Asp Ala Ile Asp
Gly Arg 435 440 445Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg
Lys Arg Lys Asn 450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu
Gln Cys Arg Glu Leu Leu Val Lys Asn 485 490 495Thr Asp Leu Pro Phe
Ile Gly Asp Ile Ser Asp Val Lys Thr Asp Ile 500 505 510Phe Leu Arg
Lys Asp Ile Asn Glu Glu Thr Glu Val Ile Tyr Tyr Pro 515 520 525Asp
Asn Val Ser Val Asp Gln Val Ile Leu Ser Lys Asn Thr Ser Glu 530 535
540His Gly Gln Leu Asp Leu Leu Tyr Pro Ser Ile Asp Ser Glu Ser
Glu545 550 555 560Ile Leu Pro Gly Glu Asn Gln Val Phe Tyr Asp Asn
Arg Thr Gln Asn 565 570 575Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr Leu
Glu Ser Gln Lys Leu Ser 580 585 590Asp Asn Val Glu Asp Phe Thr Phe
Thr Arg Ser Ile Glu Glu Ala Leu 595 600 605Asp Asn Ser Ala Lys Val
Tyr Thr Tyr Phe Pro Thr Leu Ala Asn Lys 610 615 620Val Asn Ala Gly
Val Gln Gly Gly Leu Phe Leu Met Trp Ala Asn Asp625 630 635 640Val
Val Glu Asp Phe Thr Thr Asn Ile Leu Arg Lys Asp Thr Leu Asp 645 650
655Lys Ile Ser Asp Val Ser Ala Ile Ile Pro Tyr Ile Gly Pro Ala Leu
660 665 670Asn Ile Ser Asn Ser Val Arg Arg Gly Asn Phe Thr Glu Ala
Phe Ala 675 680 685Val Thr Gly Val Thr Ile Leu Leu Glu Ala Phe Pro
Glu Phe Thr Ile 690 695 700Pro Ala Leu Gly Ala Phe Val Ile Tyr Ser
Lys Val Gln Glu Arg Asn705 710 715 720Glu Ile Ile Lys Thr Ile Asp
Asn Cys Leu Glu Gln Arg Ile Lys Arg 725 730 735Trp Lys Asp Ser Tyr
Glu Trp Met Met Gly Thr Trp Leu Ser Arg Ile 740 745 750Ile Thr Gln
Phe Asn Asn Ile Ser Tyr Gln Met Tyr Asp Ser Leu Asn 755 760 765Tyr
Gln Ala Gly Ala Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys 770 775
780Tyr Ser Gly Ser Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn
Leu785 790 795 800Lys Asn Ser Leu Asp Val Lys Ile Ser Glu Ala Met
Asn Asn Ile Asn 805 810 815Lys Phe Ile Arg Glu Cys Ser Val Thr Tyr
Leu Phe Lys Asn Met Leu 820 825 830Pro Lys Val Ile Asp Glu Leu Asn
Glu Phe Asp Arg Asn Thr Lys Ala 835 840 845Lys Leu Ile Asn Leu Ile
Asp Ser His Asn Ile Ile Leu Val Gly Glu 850 855 860Val Asp Lys Leu
Lys Ala Lys Val Asn Asn Ser Phe Gln Asn Thr Ile865 870 875 880Pro
Phe Asn Ile Phe Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile 885 890
895Ile Asn Glu Tyr Phe Asn Leu Asp 9008917PRTArtificial
SequenceSynthetic 89Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu
Lys Trp Asp Asn1 5 10 15Gln902709DNAArtificial SequenceSynthetic
90ggatccatgg agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac
60attgcttaca tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg acggcatcat tacctccaaa
1320actaaatctg acgatgacga taaatatgga ggttttttga gaaggatacg
accaaaatta 1380aagtgggata atcaagcgct agcgggcggt ggcggtagcg
gcggtggcgg tagcggcggt 1440ggcggtagcg cactagtgct gcagtgtatc
aaggttaaca actgggattt attcttcagc 1500ccgagtgaag acaacttcac
caacgacctg aacaaaggtg aagaaatcac ctcagatact 1560aacatcgaag
cagccgaaga aaacatctcg ctggacctga tccagcagta ctacctgacc
1620tttaatttcg acaacgagcc ggaaaacatt tctatcgaaa acctgagctc
tgatatcatc 1680ggccagctgg aactgatgcc gaacatcgaa cgtttcccaa
acggtaaaaa gtacgagctg 1740gacaaatata ccatgttcca ctacctgcgc
gcgcaggaat ttgaacacgg caaatcccgt 1800atcgcactga ctaactccgt
taacgaagct ctgctcaacc cgtcccgtgt atacaccttc 1860ttctctagcg
actacgtgaa aaaggtcaac aaagcgactg aagctgcaat gttcttgggt
1920tgggttgaac agcttgttta tgattttacc gacgagacgt ccgaagtatc
tactaccgac 1980aaaattgcgg atatcactat catcatcccg tacatcggtc
cggctctgaa cattggcaac 2040atgctgtaca aagacgactt cgttggcgca
ctgatcttct ccggtgcggt gatcctgctg 2100gagttcatcc cggaaatcgc
catcccggta ctgggcacct ttgctctggt ttcttacatt 2160gcaaacaagg
ttctgactgt acaaaccatc gacaacgcgc tgagcaaacg taacgaaaaa
2220tgggatgaag tttacaaata tatcgtgacc aactggctgg ctaaggttaa
tactcagatc 2280gacctcatcc gcaaaaaaat gaaagaagca ctggaaaacc
aggcggaagc taccaaggca 2340atcattaact accagtacaa ccagtacacc
gaggaagaaa aaaacaacat caacttcaac 2400atcgacgatc tgtcctctaa
actgaacgaa tccatcaaca aagctatgat caacatcaac 2460aagttcctga
accagtgctc tgtaagctat ctgatgaact ccatgatccc gtacggtgtt
2520aaacgtctgg aggacttcga tgcgtctctg aaagacgccc tgctgaaata
catttacgac 2580aaccgtggca ctctgatcgg tcaggttgat cgtctgaagg
acaaagtgaa caatacctta 2640tcgaccgaca tcccttttca gctcagtaaa
tatgtcgata accaacgcct tttgtccact 2700ctagactag
270991902PRTArtificial SequenceSynthetic 91Gly Ser Met Glu Phe Val
Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly Val Asp Ile
Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40 45Glu Arg Asp
Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro Glu
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75
80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu
85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr
Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile
Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val
Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu Leu Asn Leu
Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile Gln Phe Glu
Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu Thr Arg Asn
Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 195 200
205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala
210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala
Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu Glu Leu
Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp Ser Leu
Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile Val Gly
Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310 315
320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp
325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn
Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile
Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe
Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys
Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val
Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Asp Asp Asp Asp Lys 435 440
445Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn
450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly465 470 475 480Gly Gly Ser Ala Leu Val Leu Gln Cys Ile Lys
Val Asn Asn Trp Asp 485 490 495Leu Phe Phe Ser Pro Ser Glu Asp Asn
Phe Thr Asn Asp Leu Asn Lys 500 505 510Gly Glu Glu Ile Thr Ser Asp
Thr Asn Ile Glu Ala Ala Glu Glu Asn 515 520 525Ile Ser Leu Asp Leu
Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 530 535 540Asn Glu Pro
Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile545 550 555
560Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys
565 570 575Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg
Ala Gln 580 585 590Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr
Asn Ser Val Asn 595 600 605Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr
Thr Phe Phe Ser Ser Asp 610 615 620Tyr Val Lys Lys Val Asn Lys Ala
Thr Glu Ala Ala Met Phe Leu Gly625 630 635 640Trp Val Glu Gln Leu
Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val 645 650 655Ser Thr Thr
Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile 660 665 670Gly
Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val 675 680
685Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro
690 695 700Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser
Tyr Ile705 710 715 720Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp
Asn Ala Leu Ser Lys 725 730 735Arg Asn Glu Lys Trp Asp Glu Val Tyr
Lys Tyr Ile Val Thr Asn Trp 740 745 750Leu Ala Lys Val Asn Thr Gln
Ile Asp Leu Ile Arg Lys Lys Met Lys 755 760 765Glu Ala Leu Glu Asn
Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr 770 775 780Gln Tyr Asn
Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn785 790 795
800Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
805 810 815Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met 820 825 830Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala 835 840 845Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr 850 855 860Leu Ile Gly Gln Val Asp Arg Leu
Lys Asp Lys Val Asn Asn Thr Leu865 870 875 880Ser Thr Asp Ile Pro
Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg 885 890 895Leu Leu Ser
Thr Leu Asp 90092892PRTArtificial SequenceSynthetic 92Gly Ser Met
Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln
Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40
45Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro
50 55 60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr
Leu65 70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val
Thr Lys Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185
190Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro
195 200 205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu Ala 210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310
315 320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
Asp 325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr Tyr 355
360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys
Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr
Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile
Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys Asn Phe Thr Gly Leu
Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val Asp Gly Ile Ile Thr
Ser Lys Thr Lys Ser Asp Asp Asp Asp Lys 435 440 445Tyr Gly Gly Phe
Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn 450 455 460Gln Ala
Leu Ala Gly Gly Gly Gly Ser Ala Leu Val Leu Gln Cys Ile465 470 475
480Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe
485 490 495Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr
Asn Ile 500 505 510Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile
Gln Gln Tyr Tyr 515 520 525Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu
Asn Ile Ser Ile Glu Asn 530 535 540Leu Ser Ser Asp Ile Ile Gly Gln
Leu Glu Leu Met Pro Asn Ile Glu545 550 555 560Arg Phe Pro Asn Gly
Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe 565 570 575His Tyr Leu
Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala 580 585 590Leu
Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr 595 600
605Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu
610 615 620Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp
Phe Thr625 630 635 640Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys
Ile Ala Asp Ile Thr 645 650 655Ile Ile Ile Pro Tyr Ile Gly Pro Ala
Leu Asn Ile Gly Asn Met Leu 660 665 670Tyr Lys Asp Asp Phe Val Gly
Ala Leu Ile Phe Ser Gly Ala Val Ile 675 680 685Leu Leu Glu Phe Ile
Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe 690 695 700Ala Leu Val
Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile705 710 715
720Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys
725 730 735Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile
Asp Leu 740 745 750Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln
Ala Glu Ala Thr 755 760 765Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln
Tyr Thr Glu Glu Glu Lys 770 775 780Asn Asn Ile Asn Phe Asn Ile Asp
Asp Leu Ser Ser Lys Leu Asn Glu785 790 795 800Ser Ile Asn Lys Ala
Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys 805 810 815Ser Val Ser
Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg 820 825 830Leu
Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile 835 840
845Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys Asp
850 855 860Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu
Ser Lys865 870 875 880Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu
Asp 885 89093897PRTArtificial SequenceSynthetic 93Gly Ser Met Glu
Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly Val
Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln Pro
Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40 45Glu
Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 50 55
60Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu65
70 75 80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys
Leu 85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu
Thr Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr
Ile Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys Ile Asn
Val Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu Leu Asn
Leu Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile Gln Phe
Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu Thr Arg
Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185 190Asp
Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 195 200
205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala
210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala
Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu Glu Leu
Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp Ser Leu
Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile Val Gly
Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310 315
320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp
325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn
Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile
Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe
Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys
Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val
Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Asp Asp Asp Asp Lys 435 440
445Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn
450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu465 470 475 480Val Leu Gln Cys Ile Lys Val Asn Asn Trp Asp
Leu Phe Phe Ser Pro 485 490 495Ser Glu Asp Asn Phe Thr Asn Asp Leu
Asn Lys Gly Glu Glu Ile Thr 500 505 510Ser Asp Thr Asn Ile Glu Ala
Ala Glu Glu Asn Ile Ser Leu Asp Leu 515 520 525Ile Gln Gln Tyr Tyr
Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn 530 535 540Ile Ser Ile
Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu545 550 555
560Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp
565 570 575Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu
His Gly 580 585 590Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu
Ala Leu Leu Asn 595 600 605Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser
Asp Tyr Val Lys Lys Val 610 615 620Asn Lys Ala Thr Glu Ala Ala Met
Phe Leu Gly Trp Val Glu Gln Leu625 630 635 640Val Tyr Asp Phe Thr
Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys 645 650 655Ile Ala Asp
Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 660 665 670Ile
Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 675 680
685Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro
690 695 700Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys
Val Leu705 710 715 720Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys
Arg Asn Glu Lys Trp 725 730 735Asp Glu Val Tyr Lys Tyr Ile Val Thr
Asn Trp Leu Ala Lys Val Asn 740 745 750Thr Gln Ile Asp Leu Ile Arg
Lys Lys Met Lys Glu Ala Leu Glu Asn 755 760 765Gln Ala Glu Ala Thr
Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr 770 775 780Thr Glu Glu
Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser785 790 795
800Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys
805 810 815Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met
Ile Pro 820 825 830Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser
Leu Lys Asp Ala 835 840 845Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly
Thr Leu Ile Gly Gln Val 850 855 860Asp Arg Leu Lys Asp Lys Val Asn
Asn Thr Leu Ser Thr Asp Ile Pro865 870 875 880Phe Gln Leu Ser Lys
Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu 885 890
895Asp94907PRTArtificial SequenceSynthetic 94Gly Ser Met Glu Phe
Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val1 5 10 15Asn Gly Val Asp
Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 20 25 30Gln Pro Val
Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 35 40 45Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 50 55 60Pro
Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu65 70 75
80Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu
85 90 95Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr
Ser 100 105 110Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile
Asp Thr Glu 115 120 125Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val
Ile Gln Pro Asp Gly 130 135 140Ser Tyr Arg Ser Glu Glu Leu Asn Leu
Val Ile Ile Gly Pro Ser Ala145 150 155 160Asp Ile Ile Gln Phe Glu
Cys Lys Ser Phe Gly His Glu Val Leu Asn 165 170 175Leu Thr Arg Asn
Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 180 185 190Asp Phe
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 195 200
205Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala
210 215 220His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
Ile Asn225 230 235 240Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala
Tyr Tyr Glu Met Ser 245 250 255Gly Leu Glu Val Ser Phe Glu Glu Leu
Arg Thr Phe Gly Gly His Asp 260 265 270Ala Lys Phe Ile Asp Ser Leu
Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 275 280 285Tyr Asn Lys Phe Lys
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 290 295 300Ile Val Gly
Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys305 310 315
320Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp
325 330 335Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
Tyr Thr 340 345 350Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn
Arg Lys Thr Tyr 355 360 365Leu Asn Phe Asp Lys Ala Val Phe Lys Ile
Asn Ile Val Pro Lys Val 370 375 380Asn Tyr Thr Ile Tyr Asp Gly Phe
Asn Leu Arg Asn Thr Asn Leu Ala385 390 395 400Ala Asn Phe Asn Gly
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 405 410 415Lys Leu Lys
Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 420 425 430Val
Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Asp Asp Asp Asp Lys 435 440
445Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn
450 455 460Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly465 470 475 480Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Val
Leu Gln Cys Ile Lys 485 490 495Val Asn Asn Trp Asp Leu Phe Phe Ser
Pro Ser Glu Asp Asn Phe Thr 500 505 510Asn Asp Leu Asn Lys Gly Glu
Glu Ile Thr Ser Asp Thr Asn Ile Glu 515 520 525Ala Ala Glu Glu Asn
Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu 530 535 540Thr Phe Asn
Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu545 550 555
560Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg
565 570 575Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met
Phe His 580 585 590Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser
Arg Ile Ala Leu 595 600 605Thr Asn Ser Val Asn Glu Ala Leu Leu Asn
Pro Ser Arg Val Tyr Thr 610 615 620Phe Phe Ser Ser Asp Tyr Val Lys
Lys Val Asn Lys Ala Thr Glu Ala625 630 635 640Ala Met Phe Leu Gly
Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp 645 650 655Glu Thr Ser
Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile 660 665 670Ile
Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr 675 680
685Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu
690 695 700Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr
Phe Ala705 710 715 720Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr
Val Gln Thr Ile Asp 725 730 735Asn Ala Leu Ser Lys Arg Asn Glu Lys
Trp Asp Glu Val Tyr Lys Tyr 740 745 750Ile Val Thr Asn Trp Leu Ala
Lys Val Asn Thr Gln Ile Asp Leu Ile 755 760 765Arg Lys Lys Met Lys
Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys 770 775 780Ala Ile Ile
Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn785 790 795
800Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser
805 810 815Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln
Cys Ser 820 825 830Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly
Val Lys Arg Leu 835 840 845Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala
Leu Leu Lys Tyr Ile Tyr 850 855 860Asp Asn Arg Gly Thr Leu Ile Gly
Gln Val Asp Arg Leu Lys Asp Lys865 870 875 880Val Asn Asn Thr Leu
Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr 885 890 895Val Asp Asn
Gln Arg Leu Leu Ser Thr Leu Asp 900 90595913PRTArtificial
SequenceSynthetic 95Gly Ser Glu Phe Met Pro Ile Thr Ile Asn Asn Phe
Asn Tyr Ser Asp1 5 10 15Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp
Thr His Leu Asn Thr 20 25 30Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg
Ile Thr Gly Asn Ile Trp 35 40 45Val Ile Pro Asp Arg Phe Ser Arg Asn
Ser Asn Pro Asn Leu Asn Lys 50 55 60Pro Pro Arg Val Thr Ser Pro Lys
Ser Gly Tyr Tyr Asp Pro Asn Tyr65 70 75 80Leu Ser Thr Asp Ser Asp
Lys Asp Thr Phe Leu Lys Glu Ile Ile Lys 85 90 95Leu Phe Lys Arg Ile
Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr 100 105 110Arg Leu Ser
Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile 115
120 125Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys
Thr 130 135 140Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn
Pro Ser Val145 150 155 160Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile
Asp Pro Glu Thr Ser Thr 165 170 175Phe Lys Leu Thr Asn Asn Thr Phe
Ala Ala Gln Glu Gly Phe Gly Ala 180 185 190Leu Ser Ile Ile Ser Ile
Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn 195 200 205Ala Thr Asn Asp
Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys 210 215 220Met Asp
Pro Ile Leu Ile Leu Met His Glu Leu Asn His Ala Met His225 230 235
240Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val
245 250 255Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu
Tyr Ala 260 265 270Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu
Ile Pro Lys Ser 275 280 285Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu
Asp Tyr Tyr Arg Ser Ile 290 295 300Ala Lys Arg Leu Asn Ser Ile Thr
Thr Ala Asn Pro Ser Ser Phe Asn305 310 315 320Lys Tyr Ile Gly Glu
Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe 325 330 335Val Val Glu
Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val 340 345 350Glu
Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala 355 360
365Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr
370 375 380Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp
Ile Gln385 390 395 400Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn
Val Leu Phe Met Gly 405 410 415Gln Asn Leu Ser Arg Asn Pro Ala Leu
Arg Lys Val Asn Pro Glu Asn 420 425 430Met Leu Tyr Leu Phe Thr Lys
Phe Cys Val Asp Gly Ile Ile Thr Ser 435 440 445Lys Thr Lys Ser Asp
Asp Asp Asp Lys Tyr Gly Gly Phe Leu Arg Arg 450 455 460Ile Arg Pro
Lys Leu Lys Trp Asp Asn Gln Ala Leu Ala Gly Gly Gly465 470 475
480Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu
485 490 495Gln Cys Arg Glu Leu Leu Val Lys Asn Thr Asp Leu Pro Phe
Ile Gly 500 505 510Asp Ile Ser Asp Val Lys Thr Asp Ile Phe Leu Arg
Lys Asp Ile Asn 515 520 525Glu Glu Thr Glu Val Ile Tyr Tyr Pro Asp
Asn Val Ser Val Asp Gln 530 535 540Val Ile Leu Ser Lys Asn Thr Ser
Glu His Gly Gln Leu Asp Leu Leu545 550 555 560Tyr Pro Ser Ile Asp
Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln 565 570 575Val Phe Tyr
Asp Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr 580 585 590Tyr
Tyr Leu Glu Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr 595 600
605Phe Thr Arg Ser Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr
610 615 620Thr Tyr Phe Pro Thr Leu Ala Asn Lys Val Asn Ala Gly Val
Gln Gly625 630 635 640Gly Leu Phe Leu Met Trp Ala Asn Asp Val Val
Glu Asp Phe Thr Thr 645 650 655Asn Ile Leu Arg Lys Asp Thr Leu Asp
Lys Ile Ser Asp Val Ser Ala 660 665 670Ile Ile Pro Tyr Ile Gly Pro
Ala Leu Asn Ile Ser Asn Ser Val Arg 675 680 685Arg Gly Asn Phe Thr
Glu Ala Phe Ala Val Thr Gly Val Thr Ile Leu 690 695 700Leu Glu Ala
Phe Pro Glu Phe Thr Ile Pro Ala Leu Gly Ala Phe Val705 710 715
720Ile Tyr Ser Lys Val Gln Glu Arg Asn Glu Ile Ile Lys Thr Ile Asp
725 730 735Asn Cys Leu Glu Gln Arg Ile Lys Arg Trp Lys Asp Ser Tyr
Glu Trp 740 745 750Met Met Gly Thr Trp Leu Ser Arg Ile Ile Thr Gln
Phe Asn Asn Ile 755 760 765Ser Tyr Gln Met Tyr Asp Ser Leu Asn Tyr
Gln Ala Gly Ala Ile Lys 770 775 780Ala Lys Ile Asp Leu Glu Tyr Lys
Lys Tyr Ser Gly Ser Asp Lys Glu785 790 795 800Asn Ile Lys Ser Gln
Val Glu Asn Leu Lys Asn Ser Leu Asp Val Lys 805 810 815Ile Ser Glu
Ala Met Asn Asn Ile Asn Lys Phe Ile Arg Glu Cys Ser 820 825 830Val
Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val Ile Asp Glu Leu 835 840
845Asn Glu Phe Asp Arg Asn Thr Lys Ala Lys Leu Ile Asn Leu Ile Asp
850 855 860Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Lys Leu Lys
Ala Lys865 870 875 880Val Asn Asn Ser Phe Gln Asn Thr Ile Pro Phe
Asn Ile Phe Ser Tyr 885 890 895Thr Asn Asn Ser Leu Leu Lys Asp Ile
Ile Asn Glu Tyr Phe Asn Leu 900 905 910Asp961432PRTArtificial
SequenceSynthetic 96Gly Ser Leu Val Arg Asp Asp Val Asp Tyr Gln Ile
Phe Arg Asp Phe1 5 10 15Ala Glu Asn Lys Gly Lys Phe Phe Val Gly Ala
Thr Asp Leu Ser Val 20 25 30Lys Asn Lys Arg Gly Gln Asn Ile Gly Asn
Ala Leu Ser Asn Val Pro 35 40 45Met Ile Asp Phe Ser Val Ala Asp Val
Asn Lys Arg Ile Ala Thr Val 50 55 60Val Asp Pro Gln Tyr Ala Val Ser
Val Lys His Ala Lys Ala Glu Val65 70 75 80His Thr Phe Tyr Tyr Gly
Gln Tyr Asn Gly His Asn Asp Val Ala Asp 85 90 95Lys Glu Asn Glu Tyr
Arg Val Val Glu Gln Asn Asn Tyr Glu Pro His 100 105 110Lys Ala Trp
Gly Ala Ser Asn Leu Gly Arg Leu Glu Asp Tyr Asn Met 115 120 125Ala
Arg Phe Asn Lys Phe Val Thr Glu Val Ala Pro Ile Ala Pro Thr 130 135
140Asp Ala Gly Gly Gly Leu Asp Thr Tyr Lys Asp Lys Asn Arg Phe
Ser145 150 155 160Ser Phe Val Arg Ile Gly Ala Gly Arg Gln Leu Val
Tyr Glu Lys Gly 165 170 175Val Tyr His Gln Glu Gly Asn Glu Lys Gly
Tyr Asp Leu Arg Asp Leu 180 185 190Ser Gln Ala Tyr Arg Tyr Ala Ile
Ala Gly Thr Pro Tyr Lys Asp Ile 195 200 205Asn Ile Asp Gln Thr Met
Asn Thr Glu Gly Leu Ile Gly Phe Gly Asn 210 215 220His Asn Lys Gln
Tyr Ser Ala Glu Glu Leu Lys Gln Ala Leu Ser Gln225 230 235 240Asp
Ala Leu Thr Asn Tyr Gly Val Leu Gly Asp Ser Gly Ser Pro Leu 245 250
255Phe Ala Phe Asp Lys Gln Lys Asn Gln Trp Val Phe Leu Gly Thr Tyr
260 265 270Asp Tyr Trp Ala Gly Tyr Gly Lys Lys Ser Trp Gln Glu Trp
Asn Ile 275 280 285Tyr Lys Lys Glu Phe Ala Asp Lys Ile Lys Gln His
Asp Asn Ala Gly 290 295 300Thr Val Lys Gly Asn Gly Glu His His Trp
Lys Thr Thr Gly Thr Asn305 310 315 320Ser His Ile Gly Ser Thr Ala
Val Arg Leu Ala Asn Asn Glu Gly Asp 325 330 335Ala Asn Asn Gly Gln
Asn Val Thr Phe Glu Asp Asn Gly Thr Leu Val 340 345 350Leu Asn Gln
Asn Ile Asn Gln Gly Ala Gly Gly Leu Phe Phe Lys Gly 355 360 365Asp
Tyr Thr Val Lys Gly Ala Asn Asn Asp Ile Thr Trp Leu Gly Ala 370 375
380Gly Ile Asp Val Ala Asp Gly Lys Lys Val Val Trp Gln Val Lys
Asn385 390 395 400Pro Asn Gly Asp Arg Leu Ala Lys Ile Gly Lys Gly
Thr Leu Glu Ile 405 410 415Asn Gly Thr Gly Val Asn Gln Gly Gln Leu
Lys Val Gly Asp Gly Thr 420 425 430Val Ile Leu Asn Gln Lys Ala Asp
Ala Asp Lys Lys Val Gln Ala Phe 435 440 445Ser Gln Val Gly Ile Val
Ser Gly Arg Gly Thr Leu Val Leu Asn Ser 450 455 460Ser Asn Gln Ile
Asn Pro Asp Asn Leu Tyr Phe Gly Phe Arg Gly Gly465 470 475 480Arg
Leu Asp Ala Asn Gly Asn Asp Leu Thr Phe Glu His Ile Arg Asn 485 490
495Val Asp Glu Gly Ala Arg Ile Val Asn His Asn Thr Asp His Ala Ser
500 505 510Thr Ile Thr Leu Thr Gly Lys Ser Leu Ile Thr Asn Pro Asn
Ser Leu 515 520 525Ser Val His Ser Ile Gln Asn Asp Tyr Asp Glu Asp
Asp Tyr Ser Tyr 530 535 540Tyr Tyr Arg Pro Arg Arg Pro Ile Pro Gln
Gly Lys Asp Leu Tyr Tyr545 550 555 560Lys Asn Tyr Arg Tyr Tyr Ala
Leu Lys Ser Gly Gly Arg Leu Asn Ala 565 570 575Pro Met Pro Glu Asn
Gly Val Ala Glu Asn Asn Asp Trp Ile Phe Met 580 585 590Gly Tyr Thr
Gln Glu Glu Ala Arg Lys Asn Ala Met Asn His Lys Asn 595 600 605Asn
Arg Arg Ile Gly Asp Phe Gly Gly Phe Phe Asp Glu Glu Asn Gly 610 615
620Lys Gly His Asn Gly Ala Leu Asn Leu Asn Phe Asn Gly Lys Ser
Ala625 630 635 640Gln Lys Arg Phe Leu Leu Thr Gly Gly Ala Asn Leu
Asn Gly Lys Ile 645 650 655Ser Val Thr Gln Gly Asn Val Leu Leu Ser
Gly Arg Pro Thr Pro His 660 665 670Ala Arg Asp Phe Val Asn Lys Ser
Ser Ala Arg Lys Asp Ala His Phe 675 680 685Ser Lys Asn Asn Glu Val
Val Phe Glu Asp Asp Trp Ile Asn Arg Thr 690 695 700Phe Lys Ala Ala
Glu Ile Ala Val Asn Gln Ser Ala Ser Phe Ser Ser705 710 715 720Gly
Arg Asn Val Ser Asp Ile Thr Ala Asn Ile Thr Ala Thr Asp Asn 725 730
735Ala Lys Val Asn Leu Gly Tyr Lys Asn Gly Asp Glu Val Cys Val Arg
740 745 750Ser Asp Tyr Thr Gly Tyr Val Thr Cys Asn Thr Gly Asn Leu
Ser Asp 755 760 765Lys Ala Leu Asn Ser Phe Asp Ala Thr Arg Ile Asn
Gly Asn Val Asn 770 775 780Leu Asn Gln Asn Ala Ala Leu Val Leu Gly
Lys Ala Ala Leu Trp Gly785 790 795 800Lys Ile Gln Gly Gln Gly Asn
Ser Arg Val Ser Leu Asn Gln His Ser 805 810 815Lys Trp His Leu Thr
Gly Asp Ser Gln Val His Asn Leu Ser Leu Ala 820 825 830Asp Ser His
Ile His Leu Asn Asn Ala Ser Asp Ala Gln Ser Ala Asn 835 840 845Lys
Tyr His Thr Ile Lys Ile Asn His Leu Ser Gly Asn Gly His Phe 850 855
860His Tyr Leu Thr Asp Leu Ala Lys Asn Leu Gly Asp Lys Val Leu
Val865 870 875 880Lys Glu Ser Ala Ser Gly His Tyr Gln Leu His Val
Gln Asn Lys Thr 885 890 895Gly Glu Pro Asn Gln Glu Gly Leu Asp Leu
Phe Asp Ala Ser Ser Val 900 905 910Gln Asp Arg Ser Arg Leu Phe Val
Ser Leu Ala Asn His Tyr Val Asp 915 920 925Leu Gly Ala Leu Arg Tyr
Thr Ile Lys Thr Glu Asn Gly Ile Thr Arg 930 935 940Leu Tyr Asn Pro
Tyr Ala Gly Asn Gly Arg Pro Val Lys Pro Ala Pro945 950 955 960Cys
Val Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Asp Asp 965 970
975Asp Lys Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp
980 985 990Asp Asn Gln Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 995 1000 1005Gly Gly Gly Gly Ser Ala Leu Val Leu Gln Cys
Ile Lys Val Asn 1010 1015 1020Asn Trp Asp Leu Phe Phe Ser Pro Ser
Glu Asp Asn Phe Thr Asn 1025 1030 1035Asp Leu Asn Lys Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu 1040 1045 1050Ala Ala Glu Glu Asn
Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr 1055 1060 1065Leu Thr Phe
Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu 1070 1075 1080Asn
Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn 1085 1090
1095Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr
1100 1105 1110Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His
Gly Lys 1115 1120 1125Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu
Ala Leu Leu Asn 1130 1135 1140Pro Ser Arg Val Tyr Thr Phe Phe Ser
Ser Asp Tyr Val Lys Lys 1145 1150 1155Val Asn Lys Ala Thr Glu Ala
Ala Met Phe Leu Gly Trp Val Glu 1160 1165 1170Gln Leu Val Tyr Asp
Phe Thr Asp Glu Thr Ser Glu Val Ser Thr 1175 1180 1185Thr Asp Lys
Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly 1190 1195 1200Pro
Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val 1205 1210
1215Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile
1220 1225 1230Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu
Val Ser 1235 1240 1245Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr
Ile Asp Asn Ala 1250 1255 1260Leu Ser Lys Arg Asn Glu Lys Trp Asp
Glu Val Tyr Lys Tyr Ile 1265 1270 1275Val Thr Asn Trp Leu Ala Lys
Val Asn Thr Gln Ile Asp Leu Ile 1280 1285 1290Arg Lys Lys Met Lys
Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr 1295 1300 1305Lys Ala Ile
Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu 1310 1315 1320Lys
Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu 1325 1330
1335Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu
1340 1345 1350Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile
Pro Tyr 1355 1360 1365Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser
Leu Lys Asp Ala 1370 1375 1380Leu Leu Lys Tyr Ile Tyr Asp Asn Arg
Gly Thr Leu Ile Gly Gln 1385 1390 1395Val Asp Arg Leu Lys Asp Lys
Val Asn Asn Thr Leu Ser Thr Asp 1400 1405 1410Ile Pro Phe Gln Leu
Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu 1415 1420 1425Ser Thr Leu
Asp 143097911PRTArtificial SequenceSynthetic 97Gly Ser Met Pro Ile
Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val1 5 10 15Asn Asn Asp Thr
Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu 20 25 30Asp Ile Tyr
Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val 35 40 45Pro Glu
Arg Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro 50 55 60Ser
Ser Leu Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu65 70 75
80Arg Thr Asp Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu
85 90 95Phe Asn Arg Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp
Lys 100 105 110Ile Ile Asn Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser
Leu Leu Asp 115 120 125Lys Phe Asp Thr Asn Ser Asn Ser Val Ser Phe
Asn Leu Leu Glu Gln 130 135 140Asp Pro Ser Gly Ala Thr Thr Lys Ser
Ala Met Leu Thr Asn Leu Ile145 150 155 160Ile Phe Gly Pro Gly Pro
Val Leu Asn Lys Asn Glu Val Arg Gly Ile 165 170 175Val Leu Arg Val
Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe 180 185 190Gly Ser
Ile Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe 195 200
205Asp Asn Val Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys
210 215 220Tyr Phe Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile
His Val225 230
235 240Leu His Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile
Pro 245 250 255Ser Lys Gln Glu Ile Tyr Met Gln His Thr Tyr Pro Ile
Ser Ala Glu 260 265 270Glu Leu Phe Thr Phe Gly Gly Gln Asp Ala Asn
Leu Ile Ser Ile Asp 275 280 285Ile Lys Asn Asp Leu Tyr Glu Lys Thr
Leu Asn Asp Tyr Lys Ala Ile 290 295 300Ala Asn Lys Leu Ser Gln Val
Thr Ser Cys Asn Asp Pro Asn Ile Asp305 310 315 320Ile Asp Ser Tyr
Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys 325 330 335Asp Ser
Asn Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu 340 345
350Tyr Asn Ser Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys
355 360 365Phe Asn Ile Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His
Asp Pro 370 375 380Val Lys Ile Pro Asn Leu Leu Asp Asp Thr Ile Tyr
Asn Asp Thr Glu385 390 395 400Gly Phe Asn Ile Glu Ser Lys Asp Leu
Lys Ser Glu Tyr Lys Gly Gln 405 410 415Asn Met Arg Val Asn Thr Asn
Ala Phe Arg Asn Val Asp Gly Ser Gly 420 425 430Leu Val Ser Lys Leu
Ile Gly Leu Cys Val Asp Gly Ile Ile Thr Ser 435 440 445Lys Thr Lys
Ser Asp Asp Asp Asp Lys Tyr Gly Gly Phe Leu Arg Arg 450 455 460Ile
Arg Pro Lys Leu Lys Trp Asp Asn Gln Ala Leu Ala Gly Gly Gly465 470
475 480Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Val
Leu 485 490 495Gln Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser
Pro Ser Glu 500 505 510Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu
Glu Ile Thr Ser Asp 515 520 525Thr Asn Ile Glu Ala Ala Glu Glu Asn
Ile Ser Leu Asp Leu Ile Gln 530 535 540Gln Tyr Tyr Leu Thr Phe Asn
Phe Asp Asn Glu Pro Glu Asn Ile Ser545 550 555 560Ile Glu Asn Leu
Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro 565 570 575Asn Ile
Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr 580 585
590Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser
595 600 605Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn
Pro Ser 610 615 620Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys
Lys Val Asn Lys625 630 635 640Ala Thr Glu Ala Ala Met Phe Leu Gly
Trp Val Glu Gln Leu Val Tyr 645 650 655Asp Phe Thr Asp Glu Thr Ser
Glu Val Ser Thr Thr Asp Lys Ile Ala 660 665 670Asp Ile Thr Ile Ile
Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly 675 680 685Asn Met Leu
Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly 690 695 700Ala
Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu705 710
715 720Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr
Val 725 730 735Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys
Trp Asp Glu 740 745 750Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala
Lys Val Asn Thr Gln 755 760 765Ile Asp Leu Ile Arg Lys Lys Met Lys
Glu Ala Leu Glu Asn Gln Ala 770 775 780Glu Ala Thr Lys Ala Ile Ile
Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu785 790 795 800Glu Glu Lys Asn
Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys 805 810 815Leu Asn
Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu 820 825
830Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly
835 840 845Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala
Leu Leu 850 855 860Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly
Gln Val Asp Arg865 870 875 880Leu Lys Asp Lys Val Asn Asn Thr Leu
Ser Thr Asp Ile Pro Phe Gln 885 890 895Leu Ser Lys Tyr Val Asp Asn
Gln Arg Leu Leu Ser Thr Leu Asp 900 905 910
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