U.S. patent application number 10/231353 was filed with the patent office on 2003-01-30 for novel human phosphatases and polynucleotides encoding the same. Invention is credited to Abuin, Alejandro, Friedrich, Glenn, Sands, Arthur T., Scoville, John, Turner, C. Alexander JR., Walke, D. Wade, Zambrowicz, Brian.
Application Number | 20030023064 10/231353 |
Document ID | / |
Family ID | 26905326 |
Filed Date | 2003-01-30 |
United States Patent Application | 20030023064 |
Kind Code | A1 |
Walke, D. Wade ; et al. | January 30, 2003 |
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Inventors: | Walke, D. Wade; (Spring, TX) ; Scoville, John; (Houston, TX) ; Turner, C. Alexander JR.; (The Woodlands, TX) ; Friedrich, Glenn; (Houston, TX) ; Abuin, Alejandro; (The Woodlands, TX) ; Zambrowicz, Brian; (The Woodlands, TX) ; Sands, Arthur T.; (The Woodlands, TX) |
Correspondence Address: |
LEXICON GENETICS INCORPORATED 8800 TECHNOLOGY FOREST PLACE THE WOODLANDS TX 77381-1160 US |
Family ID: | 26905326 |
Appl. No.: | 10/231353 |
Filed: | August 28, 2002 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10231353 | Aug 28, 2002 | |||
09877730 | Jun 8, 2001 | |||
6465632 | ||||
60210607 | Jun 9, 2000 | |||
Current U.S. Class: | 536/23.2 |
Current CPC Class: | C07H 21/04 20130101; C12N 9/16 20130101; C07K 14/70503 20130101 |
Class at Publication: | 536/23.2 |
International Class: | C07H 021/04 |
Sequence CWU 1
1
31 1 3210 DNA homo sapiens 1 atggcgcctc ctctgcgacc cctcgcccgg
ctgcgaccgc cggggatgct gctccgcgcg 60 ctcctgctcc tgctgmtgct
cagtcctttg ccaggagtgt ggtgctttag cgaactgtct 120 tttgtaaaag
aaccacagga tgtaactgtc acaagaaagg acccagtcgt tttagattgc 180
caggctcacg gagaagttcc tattaaggtc acatggttga aaaatggagc aaaaatgtct
240 gaaaataaac ggatcgaggt tctttctaac ggctctttat acatcagtga
ggtggaaggc 300 aggcgaggag agcagtccga tgaaggattt tatcagtgct
tggcaatgaa caaatatgga 360 gccattctta gtcaaaaagc tcatcttgcc
ttatcaacta tttctgcatt tgaagtccag 420 ccaatttcca ctgaggtcca
cgaaggtgga gttgctcgat ttgcatgcaa gatttcatcc 480 caccctcctg
cagtcataac atgggagttc aatcggacaa ctctacctat gactatggac 540
aggataactg ccctaccaac aggagtattg cagatctatg atgtcagcca aagggattct
600 ggaaattatc gttgtattgc tgccactgta gcccaccgac gtaaaagtat
ggaggcctcg 660 ctaactgtga ttccagctaa ggagtcaaaa tccttccaca
caccarcaat tatagcaggt 720 ccacagaaca taacaacatc tcttcatcag
actgtagttt tggaatgcat ggccacagga 780 aatcccaaac caatcatttc
ttggagccgc cttgatcaca aatccattga tgtctttaat 840 actcgggtac
ttggaaatgg taatctcatg atatctgatg tcaggctaca acatgctgga 900
gtatatgttt gtcgggccac tacccctggc acacgcaact ttacagttgc tatggcaact
960 ttaactgtat tagctcctcc ttcatttgtt gaatggccag aaagtttaac
aaggcctcga 1020 gctggcactg ctcgatttgt gtgtcaggca gaaggaatcc
cctctcccaa gatgtcatgg 1080 ttgaaaaatg gaaggaagat acattcgaat
ggtagaatta aaatgtacaa cagtaaattg 1140 gtaattaacc agattattcc
tgaagatgat gctatttatc agtgcatggc tgagaatagc 1200 caaggatcta
ttttatctag agccagactg actgtagtga tgtcagaaga cagacccagt 1260
gctccctata atgtacatgc tgaaaccatg tcaagctcag ccattctttt agcctgggag
1320 aggccacttt ataattcaga caaagtcatt gcctattctg tacactacat
gaaagcagaa 1380 ggtttaaata atgaagagta tcaagtagtc atcggaaatg
acacaactca ttatattatt 1440 gatgacttag agcctgccag caattatact
ttctacattg tagcatatat gccaatggga 1500 gccagccaga tgtctgacca
tgtgacacag aatactctag aggatgttcc cctgagacct 1560 cctgaaatta
gtttgacaag tcgaagtccc actgatattc tcatctcctg gctgccaatc 1620
ccagccaaat atcggcgggg ccaagtggtg ctgtatcgct tgtctttccg cctaagtact
1680 gagaattcaa tccaagttct ggagctcccg gggaccacgc atgagtacct
tttggaaggc 1740 ctgaaacctg acagtgtcta cctggttcgg attactgctg
ccaccagagt ggggctggga 1800 gagtcatcag tatggacttc acataggacg
cccaaagcta caagcgtgaa agcccctaag 1860 tctccagagt tgcatttgga
gcctctgaac tgtaccacca tttctgtgag gtggcagcaa 1920 gatgtagagg
acacagctgc tattcagggc tacaagctgt actacaagga agaagggcag 1980
caggagaatg ggcccatttt cttggatacc aaggacctac tctatactct cagtggctta
2040 gaccccagaa gaaaatatca tgtgagactc ctggcttaca acaacataga
cgatggctat 2100 caggcagatc agactgtcag cactccagga tgcgtgtctg
ttcgtgatcg catggtccct 2160 cctccaccac caccccacca tctctatgcg
aaggctaaca cctcatcttc catcttcctg 2220 cactggagga ggcctgcatt
caccgctgca caaatcatta actacaccat ccgctgtaat 2280 cctgttggcc
tgcagaatgc ttctttggtt ctgtaccttc aaacatcaga aactcacatg 2340
ttggttcaag gtctagaacc aaacaccaaa tacgaatttg ccgttcgatt acatgtggat
2400 cagctttcca gtccttggag ccctgtagtc taccattcta ctcttccaga
agcaccagca 2460 ggcccaccag ttggagtaaa agtgacatta atagaggatg
acactgccct ggtttcttgg 2520 aaaccccctg atggcccaga aacagttgtg
acccgctata ctatcttata tgcatctagg 2580 aaggcctgga ttgcaggaga
gtggcaggtc ttacaccgtg aaggggcaat aaccatggct 2640 ttgctagaaa
acttggtagc aggaaatgtg tacattgtca agatatctgc atccaatgag 2700
gtgggagaag gacccttttc aaattctgtg gagctggcag tacttccaaa ggaaacctct
2760 gaatcaaatc agaggcccaa gcgtttagat tctgctgatg ccaaagttta
ttcaggatat 2820 taccatctgg accaaaaatc aatgactggc attgctgtag
gtgttggcat agccttgacc 2880 tgcatcctca tctgtgttct catcttgata
taccgaagta aagccaggaa atcatctgct 2940 tccaagacgg cacagaatgg
aactcaacag ttacctcgta ccagtgcctc cttagctagt 3000 ggaaatgagg
taggaaagaa cctggaagga gctgtaggaa atgaagaatc tttaatgcca 3060
atgatcatgc caaacagctt cattgatgca aaggtactga gctgcgggat ttgctgcata
3120 agccgttctt ccattcctcc tccctgtgtg tgtaaaatgt acttccccca
aaattgtatg 3180 ttgaatgtat tataccaata ctcttattaa 3210 2 1069 PRT
homo sapiens 2 Met Ala Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro
Pro Gly Met 1 5 10 15 Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu
Ser Pro Leu Pro Gly 20 25 30 Val Trp Cys Phe Ser Glu Leu Ser Phe
Val Lys Glu Pro Gln Asp Val 35 40 45 Thr Val Thr Arg Lys Asp Pro
Val Val Leu Asp Cys Gln Ala His Gly 50 55 60 Glu Val Pro Ile Lys
Val Thr Trp Leu Lys Asn Gly Ala Lys Met Ser 65 70 75 80 Glu Asn Lys
Arg Ile Glu Val Leu Ser Asn Gly Ser Leu Tyr Ile Ser 85 90 95 Glu
Val Glu Gly Arg Arg Gly Glu Gln Ser Asp Glu Gly Phe Tyr Gln 100 105
110 Cys Leu Ala Met Asn Lys Tyr Gly Ala Ile Leu Ser Gln Lys Ala His
115 120 125 Leu Ala Leu Ser Thr Ile Ser Ala Phe Glu Val Gln Pro Ile
Ser Thr 130 135 140 Glu Val His Glu Gly Gly Val Ala Arg Phe Ala Cys
Lys Ile Ser Ser 145 150 155 160 His Pro Pro Ala Val Ile Thr Trp Glu
Phe Asn Arg Thr Thr Leu Pro 165 170 175 Met Thr Met Asp Arg Ile Thr
Ala Leu Pro Thr Gly Val Leu Gln Ile 180 185 190 Tyr Asp Val Ser Gln
Arg Asp Ser Gly Asn Tyr Arg Cys Ile Ala Ala 195 200 205 Thr Val Ala
His Arg Arg Lys Ser Met Glu Ala Ser Leu Thr Val Ile 210 215 220 Pro
Ala Lys Glu Ser Lys Ser Phe His Thr Pro Thr Ile Ile Ala Gly 225 230
235 240 Pro Gln Asn Ile Thr Thr Ser Leu His Gln Thr Val Val Leu Glu
Cys 245 250 255 Met Ala Thr Gly Asn Pro Lys Pro Ile Ile Ser Trp Ser
Arg Leu Asp 260 265 270 His Lys Ser Ile Asp Val Phe Asn Thr Arg Val
Leu Gly Asn Gly Asn 275 280 285 Leu Met Ile Ser Asp Val Arg Leu Gln
His Ala Gly Val Tyr Val Cys 290 295 300 Arg Ala Thr Thr Pro Gly Thr
Arg Asn Phe Thr Val Ala Met Ala Thr 305 310 315 320 Leu Thr Val Leu
Ala Pro Pro Ser Phe Val Glu Trp Pro Glu Ser Leu 325 330 335 Thr Arg
Pro Arg Ala Gly Thr Ala Arg Phe Val Cys Gln Ala Glu Gly 340 345 350
Ile Pro Ser Pro Lys Met Ser Trp Leu Lys Asn Gly Arg Lys Ile His 355
360 365 Ser Asn Gly Arg Ile Lys Met Tyr Asn Ser Lys Leu Val Ile Asn
Gln 370 375 380 Ile Ile Pro Glu Asp Asp Ala Ile Tyr Gln Cys Met Ala
Glu Asn Ser 385 390 395 400 Gln Gly Ser Ile Leu Ser Arg Ala Arg Leu
Thr Val Val Met Ser Glu 405 410 415 Asp Arg Pro Ser Ala Pro Tyr Asn
Val His Ala Glu Thr Met Ser Ser 420 425 430 Ser Ala Ile Leu Leu Ala
Trp Glu Arg Pro Leu Tyr Asn Ser Asp Lys 435 440 445 Val Ile Ala Tyr
Ser Val His Tyr Met Lys Ala Glu Gly Leu Asn Asn 450 455 460 Glu Glu
Tyr Gln Val Val Ile Gly Asn Asp Thr Thr His Tyr Ile Ile 465 470 475
480 Asp Asp Leu Glu Pro Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr
485 490 495 Met Pro Met Gly Ala Ser Gln Met Ser Asp His Val Thr Gln
Asn Thr 500 505 510 Leu Glu Asp Val Pro Leu Arg Pro Pro Glu Ile Ser
Leu Thr Ser Arg 515 520 525 Ser Pro Thr Asp Ile Leu Ile Ser Trp Leu
Pro Ile Pro Ala Lys Tyr 530 535 540 Arg Arg Gly Gln Val Val Leu Tyr
Arg Leu Ser Phe Arg Leu Ser Thr 545 550 555 560 Glu Asn Ser Ile Gln
Val Leu Glu Leu Pro Gly Thr Thr His Glu Tyr 565 570 575 Leu Leu Glu
Gly Leu Lys Pro Asp Ser Val Tyr Leu Val Arg Ile Thr 580 585 590 Ala
Ala Thr Arg Val Gly Leu Gly Glu Ser Ser Val Trp Thr Ser His 595 600
605 Arg Thr Pro Lys Ala Thr Ser Val Lys Ala Pro Lys Ser Pro Glu Leu
610 615 620 His Leu Glu Pro Leu Asn Cys Thr Thr Ile Ser Val Arg Trp
Gln Gln 625 630 635 640 Asp Val Glu Asp Thr Ala Ala Ile Gln Gly Tyr
Lys Leu Tyr Tyr Lys 645 650 655 Glu Glu Gly Gln Gln Glu Asn Gly Pro
Ile Phe Leu Asp Thr Lys Asp 660 665 670 Leu Leu Tyr Thr Leu Ser Gly
Leu Asp Pro Arg Arg Lys Tyr His Val 675 680 685 Arg Leu Leu Ala Tyr
Asn Asn Ile Asp Asp Gly Tyr Gln Ala Asp Gln 690 695 700 Thr Val Ser
Thr Pro Gly Cys Val Ser Val Arg Asp Arg Met Val Pro 705 710 715 720
Pro Pro Pro Pro Pro His His Leu Tyr Ala Lys Ala Asn Thr Ser Ser 725
730 735 Ser Ile Phe Leu His Trp Arg Arg Pro Ala Phe Thr Ala Ala Gln
Ile 740 745 750 Ile Asn Tyr Thr Ile Arg Cys Asn Pro Val Gly Leu Gln
Asn Ala Ser 755 760 765 Leu Val Leu Tyr Leu Gln Thr Ser Glu Thr His
Met Leu Val Gln Gly 770 775 780 Leu Glu Pro Asn Thr Lys Tyr Glu Phe
Ala Val Arg Leu His Val Asp 785 790 795 800 Gln Leu Ser Ser Pro Trp
Ser Pro Val Val Tyr His Ser Thr Leu Pro 805 810 815 Glu Ala Pro Ala
Gly Pro Pro Val Gly Val Lys Val Thr Leu Ile Glu 820 825 830 Asp Asp
Thr Ala Leu Val Ser Trp Lys Pro Pro Asp Gly Pro Glu Thr 835 840 845
Val Val Thr Arg Tyr Thr Ile Leu Tyr Ala Ser Arg Lys Ala Trp Ile 850
855 860 Ala Gly Glu Trp Gln Val Leu His Arg Glu Gly Ala Ile Thr Met
Ala 865 870 875 880 Leu Leu Glu Asn Leu Val Ala Gly Asn Val Tyr Ile
Val Lys Ile Ser 885 890 895 Ala Ser Asn Glu Val Gly Glu Gly Pro Phe
Ser Asn Ser Val Glu Leu 900 905 910 Ala Val Leu Pro Lys Glu Thr Ser
Glu Ser Asn Gln Arg Pro Lys Arg 915 920 925 Leu Asp Ser Ala Asp Ala
Lys Val Tyr Ser Gly Tyr Tyr His Leu Asp 930 935 940 Gln Lys Ser Met
Thr Gly Ile Ala Val Gly Val Gly Ile Ala Leu Thr 945 950 955 960 Cys
Ile Leu Ile Cys Val Leu Ile Leu Ile Tyr Arg Ser Lys Ala Arg 965 970
975 Lys Ser Ser Ala Ser Lys Thr Ala Gln Asn Gly Thr Gln Gln Leu Pro
980 985 990 Arg Thr Ser Ala Ser Leu Ala Ser Gly Asn Glu Val Gly Lys
Asn Leu 995 1000 1005 Glu Gly Ala Val Gly Asn Glu Glu Ser Leu Met
Pro Met Ile Met Pro 1010 1015 1020 Asn Ser Phe Ile Asp Ala Lys Val
Leu Ser Cys Gly Ile Cys Cys Ile 1025 1030 1035 1040 Ser Arg Ser Ser
Ile Pro Pro Pro Cys Val Cys Lys Met Tyr Phe Pro 1045 1050 1055 Gln
Asn Cys Met Leu Asn Val Leu Tyr Gln Tyr Ser Tyr 1060 1065 3 1143
DNA homo sapiens 3 atggcgcctc ctctgcgacc cctcgcccgg ctgcgaccgc
cggggatgct gctccgcgcg 60 ctcctgctcc tgctgmtgct cagtcctttg
ccaggagtgt ggtgctttag cgaactgtct 120 tttgtaaaag aaccacagga
tgtaactgtc acaagaaagg acccagtcgt tttagattgc 180 caggctcacg
gagaagttcc tattaaggtc acatggttga aaaatggagc aaaaatgtct 240
gaaaataaac ggatcgaggt tctttctaac ggctctttat acatcagtga ggtggaaggc
300 aggcgaggag agcagtccga tgaaggattt tatcagtgct tggcaatgaa
caaatatgga 360 gccattctta gtcaaaaagc tcatcttgcc ttatcaacta
tttctgcatt tgaagtccag 420 ccaatttcca ctgaggtcca cgaaggtgga
gttgctcgat ttgcatgcaa gatttcatcc 480 caccctcctg cagtcataac
atgggagttc aatcggacaa ctctacctat gactatggac 540 aggataactg
ccctaccaac aggagtattg cagatctatg atgtcagcca aagggattct 600
ggaaattatc gttgtattgc tgccactgta gcccaccgac gtaaaagtat ggaggcctcg
660 ctaactgtga ttccagctaa ggagtcaaaa tccttccaca caccarcaat
tatagcaggt 720 ccacagaaca taacaacatc tcttcatcag actgtagttt
tggaatgcat ggccacagga 780 aatcccaaac caatcatttc ttggagccgc
cttgatcaca aatccattga tgtctttaat 840 actcgggtac ttggaaatgg
taatctcatg atatctgatg tcaggctaca acatgctgga 900 gtatatgttt
gtcgggccac tacccctggc acacgcaact ttacagttgc tatggcaact 960
ttaactgtat tagctcctcc ttcatttgtt gaatggccag aaagtttaac aaggcctcga
1020 gctggcactg ctcgatttgt gtgtcaggca gaaggaatcc cctctcccaa
gatgtcatgg 1080 ttgaaaaatg gaaggaagat acattcgaat ggtagaatta
aaatgtacaa caggtttaaa 1140 taa 1143 4 380 PRT homo sapiens 4 Met
Ala Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro Pro Gly Met 1 5 10
15 Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu Ser Pro Leu Pro Gly
20 25 30 Val Trp Cys Phe Ser Glu Leu Ser Phe Val Lys Glu Pro Gln
Asp Val 35 40 45 Thr Val Thr Arg Lys Asp Pro Val Val Leu Asp Cys
Gln Ala His Gly 50 55 60 Glu Val Pro Ile Lys Val Thr Trp Leu Lys
Asn Gly Ala Lys Met Ser 65 70 75 80 Glu Asn Lys Arg Ile Glu Val Leu
Ser Asn Gly Ser Leu Tyr Ile Ser 85 90 95 Glu Val Glu Gly Arg Arg
Gly Glu Gln Ser Asp Glu Gly Phe Tyr Gln 100 105 110 Cys Leu Ala Met
Asn Lys Tyr Gly Ala Ile Leu Ser Gln Lys Ala His 115 120 125 Leu Ala
Leu Ser Thr Ile Ser Ala Phe Glu Val Gln Pro Ile Ser Thr 130 135 140
Glu Val His Glu Gly Gly Val Ala Arg Phe Ala Cys Lys Ile Ser Ser 145
150 155 160 His Pro Pro Ala Val Ile Thr Trp Glu Phe Asn Arg Thr Thr
Leu Pro 165 170 175 Met Thr Met Asp Arg Ile Thr Ala Leu Pro Thr Gly
Val Leu Gln Ile 180 185 190 Tyr Asp Val Ser Gln Arg Asp Ser Gly Asn
Tyr Arg Cys Ile Ala Ala 195 200 205 Thr Val Ala His Arg Arg Lys Ser
Met Glu Ala Ser Leu Thr Val Ile 210 215 220 Pro Ala Lys Glu Ser Lys
Ser Phe His Thr Pro Thr Ile Ile Ala Gly 225 230 235 240 Pro Gln Asn
Ile Thr Thr Ser Leu His Gln Thr Val Val Leu Glu Cys 245 250 255 Met
Ala Thr Gly Asn Pro Lys Pro Ile Ile Ser Trp Ser Arg Leu Asp 260 265
270 His Lys Ser Ile Asp Val Phe Asn Thr Arg Val Leu Gly Asn Gly Asn
275 280 285 Leu Met Ile Ser Asp Val Arg Leu Gln His Ala Gly Val Tyr
Val Cys 290 295 300 Arg Ala Thr Thr Pro Gly Thr Arg Asn Phe Thr Val
Ala Met Ala Thr 305 310 315 320 Leu Thr Val Leu Ala Pro Pro Ser Phe
Val Glu Trp Pro Glu Ser Leu 325 330 335 Thr Arg Pro Arg Ala Gly Thr
Ala Arg Phe Val Cys Gln Ala Glu Gly 340 345 350 Ile Pro Ser Pro Lys
Met Ser Trp Leu Lys Asn Gly Arg Lys Ile His 355 360 365 Ser Asn Gly
Arg Ile Lys Met Tyr Asn Arg Phe Lys 370 375 380 5 2715 DNA homo
sapiens 5 atggcgcctc ctctgcgacc cctcgcccgg ctgcgaccgc cggggatgct
gctccgcgcg 60 ctcctgctcc tgctgmtgct cagtcctttg ccaggagtgt
ggtgctttag cgaactgtct 120 tttgtaaaag aaccacagga tgtaactgtc
acaagaaagg acccagtcgt tttagattgc 180 caggctcacg gagaagttcc
tattaaggtc acatggttga aaaatggagc aaaaatgtct 240 gaaaataaac
ggatcgaggt tctttctaac ggctctttat acatcagtga ggtggaaggc 300
aggcgaggag agcagtccga tgaaggattt tatcagtgct tggcaatgaa caaatatgga
360 gccattctta gtcaaaaagc tcatcttgcc ttatcaacta tttctgcatt
tgaagtccag 420 ccaatttcca ctgaggtcca cgaaggtgga gttgctcgat
ttgcatgcaa gatttcatcc 480 caccctcctg cagtcataac atgggagttc
aatcggacaa ctctacctat gactatggac 540 aggataactg ccctaccaac
aggagtattg cagatctatg atgtcagcca aagggattct 600 ggaaattatc
gttgtattgc tgccactgta gcccaccgac gtaaaagtat ggaggcctcg 660
ctaactgtga ttccagctaa ggagtcaaaa tccttccaca caccarcaat tatagcaggt
720 ccacagaaca taacaacatc tcttcatcag actgtagttt tggaatgcat
ggccacagga 780 aatcccaaac caatcatttc ttggagccgc cttgatcaca
aatccattga tgtctttaat 840 actcgggtac ttggaaatgg taatctcatg
atatctgatg tcaggctaca acatgctgga 900 gtatatgttt gtcgggccac
tacccctggc acacgcaact ttacagttgc tatggcaact 960 ttaactgtat
tagctcctcc ttcatttgtt gaatggccag aaagtttaac aaggcctcga 1020
gctggcactg ctcgatttgt gtgtcaggca gaaggaatcc cctctcccaa gatgtcatgg
1080 ttgaaaaatg gaaggaagat acattcgaat ggtagaatta aaatgtacaa
cagtaaattg 1140 gtaattaacc agattattcc tgaagatgat gctatttatc
agtgcatggc tgagaatagc 1200 caaggatcta ttttatctag agccagactg
actgtagtga tgtcagaaga cagacccagt 1260 gctccctata atgtacatgc
tgaaaccatg tcaagctcag ccattctttt agcctgggag 1320 aggccacttt
ataattcaga caaagtcatt gcctattctg tacactacat gaaagcagaa 1380
ggtttaaata atgaagagta tcaagtagtc atcggaaatg acacaactca ttatattatt
1440 gatgacttag agcctgccag caattatact ttctacattg tagcatatat
gccaatggga 1500 gccagccaga tgtctgacca tgtgacacag aatactctag
aggatgaccc cagaagaaaa 1560 tatcatgtga gactcctggc ttacaacaac
atagacgatg
gctatcaggc agatcagact 1620 gtcagcactc caggatgcgt gtctgttcgt
gatcgcatgg tccctcctcc accaccaccc 1680 caccatctct atgcgaaggc
taacacctca tcttccatct tcctgcactg gaggaggcct 1740 gcattcaccg
ctgcacaaat cattaactac accatccgct gtaatcctgt tggcctgcag 1800
aatgcttctt tggttctgta ccttcaaaca tcagaaactc acatgttggt tcaaggtcta
1860 gaaccaaaca ccaaatacga atttgccgtt cgattacatg tggatcagct
ttccagtcct 1920 tggagccctg tagtctacca ttctactctt ccagaagcac
cagcaggccc accagttgga 1980 gtaaaagtga cattaataga ggatgacact
gccctggttt cttggaaacc ccctgatggc 2040 ccagaaacag ttgtgacccg
ctatactatc ttatatgcat ctaggaaggc ctggattgca 2100 ggagagtggc
aggtcttaca ccgtgaaggg gcaataacca tggctttgct agaaaacttg 2160
gtagcaggaa atgtgtacat tgtcaagata tctgcatcca atgaggtggg agaaggaccc
2220 ttttcaaatt ctgtggagct ggcagtactt ccaaaggaaa cctctgaatc
aaatcagagg 2280 cccaagcgtt tagattctgc tgatgccaaa gtttattcag
gatattacca tctggaccaa 2340 aaatcaatga ctggcattgc tgtaggtgtt
ggcatagcct tgacctgcat cctcatctgt 2400 gttctcatct tgatataccg
aagtaaagcc aggaaatcat ctgcttccaa gacggcacag 2460 aatggaactc
aacagttacc tcgtaccagt gcctccttag ctagtggaaa tgaggtagga 2520
aagaacctgg aaggagctgt aggaaatgaa gaatctttaa tgccaatgat catgccaaac
2580 agcttcattg atgcaaaggt actgagctgc gggatttgct gcataagccg
ttcttccatt 2640 cctcctccct gtgtgtgtaa aatgtacttc ccccaaaatt
gtatgttgaa tgtattatac 2700 caatactctt attaa 2715 6 904 PRT homo
sapiens 6 Met Ala Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro Pro
Gly Met 1 5 10 15 Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu Ser
Pro Leu Pro Gly 20 25 30 Val Trp Cys Phe Ser Glu Leu Ser Phe Val
Lys Glu Pro Gln Asp Val 35 40 45 Thr Val Thr Arg Lys Asp Pro Val
Val Leu Asp Cys Gln Ala His Gly 50 55 60 Glu Val Pro Ile Lys Val
Thr Trp Leu Lys Asn Gly Ala Lys Met Ser 65 70 75 80 Glu Asn Lys Arg
Ile Glu Val Leu Ser Asn Gly Ser Leu Tyr Ile Ser 85 90 95 Glu Val
Glu Gly Arg Arg Gly Glu Gln Ser Asp Glu Gly Phe Tyr Gln 100 105 110
Cys Leu Ala Met Asn Lys Tyr Gly Ala Ile Leu Ser Gln Lys Ala His 115
120 125 Leu Ala Leu Ser Thr Ile Ser Ala Phe Glu Val Gln Pro Ile Ser
Thr 130 135 140 Glu Val His Glu Gly Gly Val Ala Arg Phe Ala Cys Lys
Ile Ser Ser 145 150 155 160 His Pro Pro Ala Val Ile Thr Trp Glu Phe
Asn Arg Thr Thr Leu Pro 165 170 175 Met Thr Met Asp Arg Ile Thr Ala
Leu Pro Thr Gly Val Leu Gln Ile 180 185 190 Tyr Asp Val Ser Gln Arg
Asp Ser Gly Asn Tyr Arg Cys Ile Ala Ala 195 200 205 Thr Val Ala His
Arg Arg Lys Ser Met Glu Ala Ser Leu Thr Val Ile 210 215 220 Pro Ala
Lys Glu Ser Lys Ser Phe His Thr Pro Thr Ile Ile Ala Gly 225 230 235
240 Pro Gln Asn Ile Thr Thr Ser Leu His Gln Thr Val Val Leu Glu Cys
245 250 255 Met Ala Thr Gly Asn Pro Lys Pro Ile Ile Ser Trp Ser Arg
Leu Asp 260 265 270 His Lys Ser Ile Asp Val Phe Asn Thr Arg Val Leu
Gly Asn Gly Asn 275 280 285 Leu Met Ile Ser Asp Val Arg Leu Gln His
Ala Gly Val Tyr Val Cys 290 295 300 Arg Ala Thr Thr Pro Gly Thr Arg
Asn Phe Thr Val Ala Met Ala Thr 305 310 315 320 Leu Thr Val Leu Ala
Pro Pro Ser Phe Val Glu Trp Pro Glu Ser Leu 325 330 335 Thr Arg Pro
Arg Ala Gly Thr Ala Arg Phe Val Cys Gln Ala Glu Gly 340 345 350 Ile
Pro Ser Pro Lys Met Ser Trp Leu Lys Asn Gly Arg Lys Ile His 355 360
365 Ser Asn Gly Arg Ile Lys Met Tyr Asn Ser Lys Leu Val Ile Asn Gln
370 375 380 Ile Ile Pro Glu Asp Asp Ala Ile Tyr Gln Cys Met Ala Glu
Asn Ser 385 390 395 400 Gln Gly Ser Ile Leu Ser Arg Ala Arg Leu Thr
Val Val Met Ser Glu 405 410 415 Asp Arg Pro Ser Ala Pro Tyr Asn Val
His Ala Glu Thr Met Ser Ser 420 425 430 Ser Ala Ile Leu Leu Ala Trp
Glu Arg Pro Leu Tyr Asn Ser Asp Lys 435 440 445 Val Ile Ala Tyr Ser
Val His Tyr Met Lys Ala Glu Gly Leu Asn Asn 450 455 460 Glu Glu Tyr
Gln Val Val Ile Gly Asn Asp Thr Thr His Tyr Ile Ile 465 470 475 480
Asp Asp Leu Glu Pro Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr 485
490 495 Met Pro Met Gly Ala Ser Gln Met Ser Asp His Val Thr Gln Asn
Thr 500 505 510 Leu Glu Asp Asp Pro Arg Arg Lys Tyr His Val Arg Leu
Leu Ala Tyr 515 520 525 Asn Asn Ile Asp Asp Gly Tyr Gln Ala Asp Gln
Thr Val Ser Thr Pro 530 535 540 Gly Cys Val Ser Val Arg Asp Arg Met
Val Pro Pro Pro Pro Pro Pro 545 550 555 560 His His Leu Tyr Ala Lys
Ala Asn Thr Ser Ser Ser Ile Phe Leu His 565 570 575 Trp Arg Arg Pro
Ala Phe Thr Ala Ala Gln Ile Ile Asn Tyr Thr Ile 580 585 590 Arg Cys
Asn Pro Val Gly Leu Gln Asn Ala Ser Leu Val Leu Tyr Leu 595 600 605
Gln Thr Ser Glu Thr His Met Leu Val Gln Gly Leu Glu Pro Asn Thr 610
615 620 Lys Tyr Glu Phe Ala Val Arg Leu His Val Asp Gln Leu Ser Ser
Pro 625 630 635 640 Trp Ser Pro Val Val Tyr His Ser Thr Leu Pro Glu
Ala Pro Ala Gly 645 650 655 Pro Pro Val Gly Val Lys Val Thr Leu Ile
Glu Asp Asp Thr Ala Leu 660 665 670 Val Ser Trp Lys Pro Pro Asp Gly
Pro Glu Thr Val Val Thr Arg Tyr 675 680 685 Thr Ile Leu Tyr Ala Ser
Arg Lys Ala Trp Ile Ala Gly Glu Trp Gln 690 695 700 Val Leu His Arg
Glu Gly Ala Ile Thr Met Ala Leu Leu Glu Asn Leu 705 710 715 720 Val
Ala Gly Asn Val Tyr Ile Val Lys Ile Ser Ala Ser Asn Glu Val 725 730
735 Gly Glu Gly Pro Phe Ser Asn Ser Val Glu Leu Ala Val Leu Pro Lys
740 745 750 Glu Thr Ser Glu Ser Asn Gln Arg Pro Lys Arg Leu Asp Ser
Ala Asp 755 760 765 Ala Lys Val Tyr Ser Gly Tyr Tyr His Leu Asp Gln
Lys Ser Met Thr 770 775 780 Gly Ile Ala Val Gly Val Gly Ile Ala Leu
Thr Cys Ile Leu Ile Cys 785 790 795 800 Val Leu Ile Leu Ile Tyr Arg
Ser Lys Ala Arg Lys Ser Ser Ala Ser 805 810 815 Lys Thr Ala Gln Asn
Gly Thr Gln Gln Leu Pro Arg Thr Ser Ala Ser 820 825 830 Leu Ala Ser
Gly Asn Glu Val Gly Lys Asn Leu Glu Gly Ala Val Gly 835 840 845 Asn
Glu Glu Ser Leu Met Pro Met Ile Met Pro Asn Ser Phe Ile Asp 850 855
860 Ala Lys Val Leu Ser Cys Gly Ile Cys Cys Ile Ser Arg Ser Ser Ile
865 870 875 880 Pro Pro Pro Cys Val Cys Lys Met Tyr Phe Pro Gln Asn
Cys Met Leu 885 890 895 Asn Val Leu Tyr Gln Tyr Ser Tyr 900 7 3453
DNA homo sapiens 7 atggcgcctc ctctgcgacc cctcgcccgg ctgcgaccgc
cggggatgct gctccgcgcg 60 ctcctgctcc tgctgmtgct cagtcctttg
ccaggagtgt ggtgctttag cgaactgtct 120 tttgtaaaag aaccacagga
tgtaactgtc acaagaaagg acccagtcgt tttagattgc 180 caggctcacg
gagaagttcc tattaaggtc acatggttga aaaatggagc aaaaatgtct 240
gaaaataaac ggatcgaggt tctttctaac ggctctttat acatcagtga ggtggaaggc
300 aggcgaggag agcagtccga tgaaggattt tatcagtgct tggcaatgaa
caaatatgga 360 gccattctta gtcaaaaagc tcatcttgcc ttatcaacta
tttctgcatt tgaagtccag 420 ccaatttcca ctgaggtcca cgaaggtgga
gttgctcgat ttgcatgcaa gatttcatcc 480 caccctcctg cagtcataac
atgggagttc aatcggacaa ctctacctat gactatggac 540 aggataactg
ccctaccaac aggagtattg cagatctatg atgtcagcca aagggattct 600
ggaaattatc gttgtattgc tgccactgta gcccaccgac gtaaaagtat ggaggcctcg
660 ctaactgtga ttccagctaa ggagtcaaaa tccttccaca caccaacaat
tatagcaggt 720 ccacagaaca taacaacatc tcttcatcag actgtagttt
tggaatgcat ggccacagga 780 aatcccaaac caatcatttc ttggagccgc
cttgatcaca aatccattga tgtctttaat 840 actcgggtac ttggaaatgg
taatctcatg atatctgatg tcaggctaca acatgctgga 900 gtatatgttt
gtcgggccac tacccctggc acacgcaact ttacagttgc tatggcaact 960
ttaactgtat tagctcctcc ttcatttgtt gaatggccag aaagtttaac aaggcctcga
1020 gctggcactg ctcgatttgt gtgtcaggca gaaggaatcc cctctcccaa
gatgtcatgg 1080 ttgaaaaatg gaaggaagat acattcgaat ggtagaatta
aaatgtacaa cagtaaattg 1140 gtaattaacc agattattcc tgaagatgat
gctatttatc agtgcatggc tgagaatagc 1200 caaggatcta ttttatctag
agccagactg actgtagtga tgtcagaaga cagacccagt 1260 gctccctata
atgtacatgc tgaaaccatg tcaagctcag ccattctttt agcctgggag 1320
aggccacttt ataattcaga caaagtcatt gcctattctg tacactacat gaaagcagaa
1380 ggtttaaata atgaagagta tcaagtagtc atcggaaatg acacaactca
ttatattatt 1440 gatgacttag agcctgccag caattatact ttctacattg
tagcatatat gccaatggga 1500 gccagccaga tgtctgacca tgtgacacag
aatactctag aggatgttcc cctgagacct 1560 cctgaaatta gtttgacaag
tcgaagtccc actgatattc tcatctcctg gctgccaatc 1620 ccagccaaat
atcggcgggg ccaagtggtg ctgtatcgct tgtctttccg cctaagtact 1680
gagaattcaa tccaagttct ggagctcccg gggaccacgc atgagtacct tttggaaggc
1740 ctgaaacctg acagtgtcta cctggttcgg attactgctg ccaccagagt
ggggctggga 1800 gagtcatcag tatggacttc acataggacg cccaaagcta
caagcgtgaa agcccctaag 1860 tctccagagt tgcatttgga gcctctgaac
tgtaccacca tttctgtgag gtggcagcaa 1920 gatgtagagg acacagctgc
tattcagggc tacaagctgt actacaagga agaagggcag 1980 caggagaatg
ggcccatttt cttggatacc aaggacctac tctatactct cagtggctta 2040
gaccccagaa gaaaatatca tgtgagactc ctggcttaca acaacataga cgatggctat
2100 caggcagatc agactgtcag cactccagga tgcgtgtctg ttcgtgatcg
catggtccct 2160 cctccaccac caccccacca tctctatgcg aaggctaaca
cctcatcttc catcttcctg 2220 cactggagga ggcctgcatt caccgctgca
caaatcatta actacaccat ccgctgtaat 2280 cctgttggcc tgcagaatgc
ttctttggtt ctgtaccttc aaacatcaga aactcacatg 2340 ttggttcaag
gtctagaacc aaacaccaaa tacgaatttg ccgttcgatt acatgtggat 2400
cagctttcca gtccttggag ccctgtagtc taccattcta ctcttccaga agcaccagca
2460 ggcccaccag ttggagtaaa agtgacatta atagaggatg acactgccct
ggtttcttgg 2520 aaaccccctg atggcccaga aacagttgtg acccgctata
ctatcttata tgcatctagg 2580 aaggcctgga ttgcaggaga gtggcaggtc
ttacaccgtg aaggggcaat aaccatggct 2640 ttgctagaaa acttggtagc
aggaaatgtg tacattgtca agatatctgc atccaatgag 2700 gtgggagaag
gacccttttc aaattctgtg gagctggcag tacttccaaa ggaaacctct 2760
gaatcaaatc agaggcccaa gcgtttagat tctgctgatg ccaaagttta ttcaggatat
2820 taccatctgg accaaaaatc aatgactggc attgctgtag gtgttggcat
agccttgacc 2880 tgcatcctca tctgtgttct catcttgata taccgaagta
aagccaggaa atcatctgct 2940 tccaagacgg cacagaatgg aactcaacag
ttacctcgta ccagtgcctc cttagctagt 3000 ggaaatgagg taggaaagaa
cctggaagga gctgtaggaa atgaagaatc tttaatgcca 3060 atgatcatgc
caaacagctt cattgatgca aagggaggaa ctgacctgat aattaatagc 3120
tatggtccta taattaaaaa caactctaag aaaaagtggt tttttttcca agactcaaag
3180 aagatacaag ttgagcagcc tcaaagaaga tttactccag cggtctgctt
ttaccagcca 3240 ggcaccactg tattaatcag tgatgaagac tcccctagct
ccccaggtca gacaaccagc 3300 ttctcaagac cctttggtgt tgcagctgat
acagaacatt cagcaaatag tgaaggcagc 3360 catgagactg gggattctgg
gcggttttct catgagtcca acgatgagat acatctgtcc 3420 tcagttataa
gtaccacacc ccccaacctc tga 3453 8 1150 PRT homo sapiens 8 Met Ala
Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro Pro Gly Met 1 5 10 15
Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu Ser Pro Leu Pro Gly 20
25 30 Val Trp Cys Phe Ser Glu Leu Ser Phe Val Lys Glu Pro Gln Asp
Val 35 40 45 Thr Val Thr Arg Lys Asp Pro Val Val Leu Asp Cys Gln
Ala His Gly 50 55 60 Glu Val Pro Ile Lys Val Thr Trp Leu Lys Asn
Gly Ala Lys Met Ser 65 70 75 80 Glu Asn Lys Arg Ile Glu Val Leu Ser
Asn Gly Ser Leu Tyr Ile Ser 85 90 95 Glu Val Glu Gly Arg Arg Gly
Glu Gln Ser Asp Glu Gly Phe Tyr Gln 100 105 110 Cys Leu Ala Met Asn
Lys Tyr Gly Ala Ile Leu Ser Gln Lys Ala His 115 120 125 Leu Ala Leu
Ser Thr Ile Ser Ala Phe Glu Val Gln Pro Ile Ser Thr 130 135 140 Glu
Val His Glu Gly Gly Val Ala Arg Phe Ala Cys Lys Ile Ser Ser 145 150
155 160 His Pro Pro Ala Val Ile Thr Trp Glu Phe Asn Arg Thr Thr Leu
Pro 165 170 175 Met Thr Met Asp Arg Ile Thr Ala Leu Pro Thr Gly Val
Leu Gln Ile 180 185 190 Tyr Asp Val Ser Gln Arg Asp Ser Gly Asn Tyr
Arg Cys Ile Ala Ala 195 200 205 Thr Val Ala His Arg Arg Lys Ser Met
Glu Ala Ser Leu Thr Val Ile 210 215 220 Pro Ala Lys Glu Ser Lys Ser
Phe His Thr Pro Thr Ile Ile Ala Gly 225 230 235 240 Pro Gln Asn Ile
Thr Thr Ser Leu His Gln Thr Val Val Leu Glu Cys 245 250 255 Met Ala
Thr Gly Asn Pro Lys Pro Ile Ile Ser Trp Ser Arg Leu Asp 260 265 270
His Lys Ser Ile Asp Val Phe Asn Thr Arg Val Leu Gly Asn Gly Asn 275
280 285 Leu Met Ile Ser Asp Val Arg Leu Gln His Ala Gly Val Tyr Val
Cys 290 295 300 Arg Ala Thr Thr Pro Gly Thr Arg Asn Phe Thr Val Ala
Met Ala Thr 305 310 315 320 Leu Thr Val Leu Ala Pro Pro Ser Phe Val
Glu Trp Pro Glu Ser Leu 325 330 335 Thr Arg Pro Arg Ala Gly Thr Ala
Arg Phe Val Cys Gln Ala Glu Gly 340 345 350 Ile Pro Ser Pro Lys Met
Ser Trp Leu Lys Asn Gly Arg Lys Ile His 355 360 365 Ser Asn Gly Arg
Ile Lys Met Tyr Asn Ser Lys Leu Val Ile Asn Gln 370 375 380 Ile Ile
Pro Glu Asp Asp Ala Ile Tyr Gln Cys Met Ala Glu Asn Ser 385 390 395
400 Gln Gly Ser Ile Leu Ser Arg Ala Arg Leu Thr Val Val Met Ser Glu
405 410 415 Asp Arg Pro Ser Ala Pro Tyr Asn Val His Ala Glu Thr Met
Ser Ser 420 425 430 Ser Ala Ile Leu Leu Ala Trp Glu Arg Pro Leu Tyr
Asn Ser Asp Lys 435 440 445 Val Ile Ala Tyr Ser Val His Tyr Met Lys
Ala Glu Gly Leu Asn Asn 450 455 460 Glu Glu Tyr Gln Val Val Ile Gly
Asn Asp Thr Thr His Tyr Ile Ile 465 470 475 480 Asp Asp Leu Glu Pro
Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr 485 490 495 Met Pro Met
Gly Ala Ser Gln Met Ser Asp His Val Thr Gln Asn Thr 500 505 510 Leu
Glu Asp Val Pro Leu Arg Pro Pro Glu Ile Ser Leu Thr Ser Arg 515 520
525 Ser Pro Thr Asp Ile Leu Ile Ser Trp Leu Pro Ile Pro Ala Lys Tyr
530 535 540 Arg Arg Gly Gln Val Val Leu Tyr Arg Leu Ser Phe Arg Leu
Ser Thr 545 550 555 560 Glu Asn Ser Ile Gln Val Leu Glu Leu Pro Gly
Thr Thr His Glu Tyr 565 570 575 Leu Leu Glu Gly Leu Lys Pro Asp Ser
Val Tyr Leu Val Arg Ile Thr 580 585 590 Ala Ala Thr Arg Val Gly Leu
Gly Glu Ser Ser Val Trp Thr Ser His 595 600 605 Arg Thr Pro Lys Ala
Thr Ser Val Lys Ala Pro Lys Ser Pro Glu Leu 610 615 620 His Leu Glu
Pro Leu Asn Cys Thr Thr Ile Ser Val Arg Trp Gln Gln 625 630 635 640
Asp Val Glu Asp Thr Ala Ala Ile Gln Gly Tyr Lys Leu Tyr Tyr Lys 645
650 655 Glu Glu Gly Gln Gln Glu Asn Gly Pro Ile Phe Leu Asp Thr Lys
Asp 660 665 670 Leu Leu Tyr Thr Leu Ser Gly Leu Asp Pro Arg Arg Lys
Tyr His Val 675 680 685 Arg Leu Leu Ala Tyr Asn Asn Ile Asp Asp Gly
Tyr Gln Ala Asp Gln 690 695 700 Thr Val Ser Thr Pro Gly Cys Val Ser
Val Arg Asp Arg Met Val Pro 705 710 715 720 Pro Pro Pro Pro Pro His
His Leu Tyr Ala Lys Ala Asn Thr Ser Ser 725 730 735 Ser Ile Phe Leu
His Trp Arg Arg Pro Ala Phe Thr Ala Ala Gln Ile 740 745 750 Ile Asn
Tyr Thr Ile Arg Cys Asn Pro Val Gly Leu Gln Asn Ala Ser 755 760 765
Leu Val Leu Tyr Leu Gln Thr Ser Glu Thr His Met Leu Val Gln Gly
770
775 780 Leu Glu Pro Asn Thr Lys Tyr Glu Phe Ala Val Arg Leu His Val
Asp 785 790 795 800 Gln Leu Ser Ser Pro Trp Ser Pro Val Val Tyr His
Ser Thr Leu Pro 805 810 815 Glu Ala Pro Ala Gly Pro Pro Val Gly Val
Lys Val Thr Leu Ile Glu 820 825 830 Asp Asp Thr Ala Leu Val Ser Trp
Lys Pro Pro Asp Gly Pro Glu Thr 835 840 845 Val Val Thr Arg Tyr Thr
Ile Leu Tyr Ala Ser Arg Lys Ala Trp Ile 850 855 860 Ala Gly Glu Trp
Gln Val Leu His Arg Glu Gly Ala Ile Thr Met Ala 865 870 875 880 Leu
Leu Glu Asn Leu Val Ala Gly Asn Val Tyr Ile Val Lys Ile Ser 885 890
895 Ala Ser Asn Glu Val Gly Glu Gly Pro Phe Ser Asn Ser Val Glu Leu
900 905 910 Ala Val Leu Pro Lys Glu Thr Ser Glu Ser Asn Gln Arg Pro
Lys Arg 915 920 925 Leu Asp Ser Ala Asp Ala Lys Val Tyr Ser Gly Tyr
Tyr His Leu Asp 930 935 940 Gln Lys Ser Met Thr Gly Ile Ala Val Gly
Val Gly Ile Ala Leu Thr 945 950 955 960 Cys Ile Leu Ile Cys Val Leu
Ile Leu Ile Tyr Arg Ser Lys Ala Arg 965 970 975 Lys Ser Ser Ala Ser
Lys Thr Ala Gln Asn Gly Thr Gln Gln Leu Pro 980 985 990 Arg Thr Ser
Ala Ser Leu Ala Ser Gly Asn Glu Val Gly Lys Asn Leu 995 1000 1005
Glu Gly Ala Val Gly Asn Glu Glu Ser Leu Met Pro Met Ile Met Pro
1010 1015 1020 Asn Ser Phe Ile Asp Ala Lys Gly Gly Thr Asp Leu Ile
Ile Asn Ser 1025 1030 1035 1040 Tyr Gly Pro Ile Ile Lys Asn Asn Ser
Lys Lys Lys Trp Phe Phe Phe 1045 1050 1055 Gln Asp Ser Lys Lys Ile
Gln Val Glu Gln Pro Gln Arg Arg Phe Thr 1060 1065 1070 Pro Ala Val
Cys Phe Tyr Gln Pro Gly Thr Thr Val Leu Ile Ser Asp 1075 1080 1085
Glu Asp Ser Pro Ser Ser Pro Gly Gln Thr Thr Ser Phe Ser Arg Pro
1090 1095 1100 Phe Gly Val Ala Ala Asp Thr Glu His Ser Ala Asn Ser
Glu Gly Ser 1105 1110 1115 1120 His Glu Thr Gly Asp Ser Gly Arg Phe
Ser His Glu Ser Asn Asp Glu 1125 1130 1135 Ile His Leu Ser Ser Val
Ile Ser Thr Thr Pro Pro Asn Leu 1140 1145 1150 9 2958 DNA homo
sapiens 9 atggcgcctc ctctgcgacc cctcgcccgg ctgcgaccgc cggggatgct
gctccgcgcg 60 ctcctgctcc tgctgmtgct cagtcctttg ccaggagtgt
ggtgctttag cgaactgtct 120 tttgtaaaag aaccacagga tgtaactgtc
acaagaaagg acccagtcgt tttagattgc 180 caggctcacg gagaagttcc
tattaaggtc acatggttga aaaatggagc aaaaatgtct 240 gaaaataaac
ggatcgaggt tctttctaac ggctctttat acatcagtga ggtggaaggc 300
aggcgaggag agcagtccga tgaaggattt tatcagtgct tggcaatgaa caaatatgga
360 gccattctta gtcaaaaagc tcatcttgcc ttatcaacta tttctgcatt
tgaagtccag 420 ccaatttcca ctgaggtcca cgaaggtgga gttgctcgat
ttgcatgcaa gatttcatcc 480 caccctcctg cagtcataac atgggagttc
aatcggacaa ctctacctat gactatggac 540 aggataactg ccctaccaac
aggagtattg cagatctatg atgtcagcca aagggattct 600 ggaaattatc
gttgtattgc tgccactgta gcccaccgac gtaaaagtat ggaggcctcg 660
ctaactgtga ttccagctaa ggagtcaaaa tccttccaca caccarcaat tatagcaggt
720 ccacagaaca taacaacatc tcttcatcag actgtagttt tggaatgcat
ggccacagga 780 aatcccaaac caatcatttc ttggagccgc cttgatcaca
aatccattga tgtctttaat 840 actcgggtac ttggaaatgg taatctcatg
atatctgatg tcaggctaca acatgctgga 900 gtatatgttt gtcgggccac
tacccctggc acacgcaact ttacagttgc tatggcaact 960 ttaactgtat
tagctcctcc ttcatttgtt gaatggccag aaagtttaac aaggcctcga 1020
gctggcactg ctcgatttgt gtgtcaggca gaaggaatcc cctctcccaa gatgtcatgg
1080 ttgaaaaatg gaaggaagat acattcgaat ggtagaatta aaatgtacaa
cagtaaattg 1140 gtaattaacc agattattcc tgaagatgat gctatttatc
agtgcatggc tgagaatagc 1200 caaggatcta ttttatctag agccagactg
actgtagtga tgtcagaaga cagacccagt 1260 gctccctata atgtacatgc
tgaaaccatg tcaagctcag ccattctttt agcctgggag 1320 aggccacttt
ataattcaga caaagtcatt gcctattctg tacactacat gaaagcagaa 1380
ggtttaaata atgaagagta tcaagtagtc atcggaaatg acacaactca ttatattatt
1440 gatgacttag agcctgccag caattatact ttctacattg tagcatatat
gccaatggga 1500 gccagccaga tgtctgacca tgtgacacag aatactctag
aggatgaccc cagaagaaaa 1560 tatcatgtga gactcctggc ttacaacaac
atagacgatg gctatcaggc agatcagact 1620 gtcagcactc caggatgcgt
gtctgttcgt gatcgcatgg tccctcctcc accaccaccc 1680 caccatctct
atgcgaaggc taacacctca tcttccatct tcctgcactg gaggaggcct 1740
gcattcaccg ctgcacaaat cattaactac accatccgct gtaatcctgt tggcctgcag
1800 aatgcttctt tggttctgta ccttcaaaca tcagaaactc acatgttggt
tcaaggtcta 1860 gaaccaaaca ccaaatacga atttgccgtt cgattacatg
tggatcagct ttccagtcct 1920 tggagccctg tagtctacca ttctactctt
ccagaagcac cagcaggccc accagttgga 1980 gtaaaagtga cattaataga
ggatgacact gccctggttt cttggaaacc ccctgatggc 2040 ccagaaacag
ttgtgacccg ctatactatc ttatatgcat ctaggaaggc ctggattgca 2100
ggagagtggc aggtcttaca ccgtgaaggg gcaataacca tggctttgct agaaaacttg
2160 gtagcaggaa atgtgtacat tgtcaagata tctgcatcca atgaggtggg
agaaggaccc 2220 ttttcaaatt ctgtggagct ggcagtactt ccaaaggaaa
cctctgaatc aaatcagagg 2280 cccaagcgtt tagattctgc tgatgccaaa
gtttattcag gatattacca tctggaccaa 2340 aaatcaatga ctggcattgc
tgtaggtgtt ggcatagcct tgacctgcat cctcatctgt 2400 gttctcatct
tgatataccg aagtaaagcc aggaaatcat ctgcttccaa gacggcacag 2460
aatggaactc aacagttacc tcgtaccagt gcctccttag ctagtggaaa tgaggtagga
2520 aagaacctgg aaggagctgt aggaaatgaa gaatctttaa tgccaatgat
catgccaaac 2580 agcttcattg atgcaaaggg aggaactgac ctgataatta
atagctatgg tcctataatt 2640 aaaaacaact ctaagaaaaa gtggtttttt
ttccaagact caaagaagat acaagttgag 2700 cagcctcaaa gaagatttac
tccagcggtc tgcttttacc agccaggcac cactgtatta 2760 atcagtgatg
aagactcccc tagctcccca ggtcagacaa ccagcttctc aagacccttt 2820
ggtgttgcag ctgatacaga acattcagca aatagtgaag gcagccatga gactggggat
2880 tctgggcggt tttctcatga gtccaacgat gagatacatc tgtcctcagt
tataagtacc 2940 acacccccca acctctga 2958 10 985 PRT homo sapiens 10
Met Ala Pro Pro Leu Arg Pro Leu Ala Arg Leu Arg Pro Pro Gly Met 1 5
10 15 Leu Leu Arg Ala Leu Leu Leu Leu Leu Leu Leu Ser Pro Leu Pro
Gly 20 25 30 Val Trp Cys Phe Ser Glu Leu Ser Phe Val Lys Glu Pro
Gln Asp Val 35 40 45 Thr Val Thr Arg Lys Asp Pro Val Val Leu Asp
Cys Gln Ala His Gly 50 55 60 Glu Val Pro Ile Lys Val Thr Trp Leu
Lys Asn Gly Ala Lys Met Ser 65 70 75 80 Glu Asn Lys Arg Ile Glu Val
Leu Ser Asn Gly Ser Leu Tyr Ile Ser 85 90 95 Glu Val Glu Gly Arg
Arg Gly Glu Gln Ser Asp Glu Gly Phe Tyr Gln 100 105 110 Cys Leu Ala
Met Asn Lys Tyr Gly Ala Ile Leu Ser Gln Lys Ala His 115 120 125 Leu
Ala Leu Ser Thr Ile Ser Ala Phe Glu Val Gln Pro Ile Ser Thr 130 135
140 Glu Val His Glu Gly Gly Val Ala Arg Phe Ala Cys Lys Ile Ser Ser
145 150 155 160 His Pro Pro Ala Val Ile Thr Trp Glu Phe Asn Arg Thr
Thr Leu Pro 165 170 175 Met Thr Met Asp Arg Ile Thr Ala Leu Pro Thr
Gly Val Leu Gln Ile 180 185 190 Tyr Asp Val Ser Gln Arg Asp Ser Gly
Asn Tyr Arg Cys Ile Ala Ala 195 200 205 Thr Val Ala His Arg Arg Lys
Ser Met Glu Ala Ser Leu Thr Val Ile 210 215 220 Pro Ala Lys Glu Ser
Lys Ser Phe His Thr Pro Thr Ile Ile Ala Gly 225 230 235 240 Pro Gln
Asn Ile Thr Thr Ser Leu His Gln Thr Val Val Leu Glu Cys 245 250 255
Met Ala Thr Gly Asn Pro Lys Pro Ile Ile Ser Trp Ser Arg Leu Asp 260
265 270 His Lys Ser Ile Asp Val Phe Asn Thr Arg Val Leu Gly Asn Gly
Asn 275 280 285 Leu Met Ile Ser Asp Val Arg Leu Gln His Ala Gly Val
Tyr Val Cys 290 295 300 Arg Ala Thr Thr Pro Gly Thr Arg Asn Phe Thr
Val Ala Met Ala Thr 305 310 315 320 Leu Thr Val Leu Ala Pro Pro Ser
Phe Val Glu Trp Pro Glu Ser Leu 325 330 335 Thr Arg Pro Arg Ala Gly
Thr Ala Arg Phe Val Cys Gln Ala Glu Gly 340 345 350 Ile Pro Ser Pro
Lys Met Ser Trp Leu Lys Asn Gly Arg Lys Ile His 355 360 365 Ser Asn
Gly Arg Ile Lys Met Tyr Asn Ser Lys Leu Val Ile Asn Gln 370 375 380
Ile Ile Pro Glu Asp Asp Ala Ile Tyr Gln Cys Met Ala Glu Asn Ser 385
390 395 400 Gln Gly Ser Ile Leu Ser Arg Ala Arg Leu Thr Val Val Met
Ser Glu 405 410 415 Asp Arg Pro Ser Ala Pro Tyr Asn Val His Ala Glu
Thr Met Ser Ser 420 425 430 Ser Ala Ile Leu Leu Ala Trp Glu Arg Pro
Leu Tyr Asn Ser Asp Lys 435 440 445 Val Ile Ala Tyr Ser Val His Tyr
Met Lys Ala Glu Gly Leu Asn Asn 450 455 460 Glu Glu Tyr Gln Val Val
Ile Gly Asn Asp Thr Thr His Tyr Ile Ile 465 470 475 480 Asp Asp Leu
Glu Pro Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr 485 490 495 Met
Pro Met Gly Ala Ser Gln Met Ser Asp His Val Thr Gln Asn Thr 500 505
510 Leu Glu Asp Asp Pro Arg Arg Lys Tyr His Val Arg Leu Leu Ala Tyr
515 520 525 Asn Asn Ile Asp Asp Gly Tyr Gln Ala Asp Gln Thr Val Ser
Thr Pro 530 535 540 Gly Cys Val Ser Val Arg Asp Arg Met Val Pro Pro
Pro Pro Pro Pro 545 550 555 560 His His Leu Tyr Ala Lys Ala Asn Thr
Ser Ser Ser Ile Phe Leu His 565 570 575 Trp Arg Arg Pro Ala Phe Thr
Ala Ala Gln Ile Ile Asn Tyr Thr Ile 580 585 590 Arg Cys Asn Pro Val
Gly Leu Gln Asn Ala Ser Leu Val Leu Tyr Leu 595 600 605 Gln Thr Ser
Glu Thr His Met Leu Val Gln Gly Leu Glu Pro Asn Thr 610 615 620 Lys
Tyr Glu Phe Ala Val Arg Leu His Val Asp Gln Leu Ser Ser Pro 625 630
635 640 Trp Ser Pro Val Val Tyr His Ser Thr Leu Pro Glu Ala Pro Ala
Gly 645 650 655 Pro Pro Val Gly Val Lys Val Thr Leu Ile Glu Asp Asp
Thr Ala Leu 660 665 670 Val Ser Trp Lys Pro Pro Asp Gly Pro Glu Thr
Val Val Thr Arg Tyr 675 680 685 Thr Ile Leu Tyr Ala Ser Arg Lys Ala
Trp Ile Ala Gly Glu Trp Gln 690 695 700 Val Leu His Arg Glu Gly Ala
Ile Thr Met Ala Leu Leu Glu Asn Leu 705 710 715 720 Val Ala Gly Asn
Val Tyr Ile Val Lys Ile Ser Ala Ser Asn Glu Val 725 730 735 Gly Glu
Gly Pro Phe Ser Asn Ser Val Glu Leu Ala Val Leu Pro Lys 740 745 750
Glu Thr Ser Glu Ser Asn Gln Arg Pro Lys Arg Leu Asp Ser Ala Asp 755
760 765 Ala Lys Val Tyr Ser Gly Tyr Tyr His Leu Asp Gln Lys Ser Met
Thr 770 775 780 Gly Ile Ala Val Gly Val Gly Ile Ala Leu Thr Cys Ile
Leu Ile Cys 785 790 795 800 Val Leu Ile Leu Ile Tyr Arg Ser Lys Ala
Arg Lys Ser Ser Ala Ser 805 810 815 Lys Thr Ala Gln Asn Gly Thr Gln
Gln Leu Pro Arg Thr Ser Ala Ser 820 825 830 Leu Ala Ser Gly Asn Glu
Val Gly Lys Asn Leu Glu Gly Ala Val Gly 835 840 845 Asn Glu Glu Ser
Leu Met Pro Met Ile Met Pro Asn Ser Phe Ile Asp 850 855 860 Ala Lys
Gly Gly Thr Asp Leu Ile Ile Asn Ser Tyr Gly Pro Ile Ile 865 870 875
880 Lys Asn Asn Ser Lys Lys Lys Trp Phe Phe Phe Gln Asp Ser Lys Lys
885 890 895 Ile Gln Val Glu Gln Pro Gln Arg Arg Phe Thr Pro Ala Val
Cys Phe 900 905 910 Tyr Gln Pro Gly Thr Thr Val Leu Ile Ser Asp Glu
Asp Ser Pro Ser 915 920 925 Ser Pro Gly Gln Thr Thr Ser Phe Ser Arg
Pro Phe Gly Val Ala Ala 930 935 940 Asp Thr Glu His Ser Ala Asn Ser
Glu Gly Ser His Glu Thr Gly Asp 945 950 955 960 Ser Gly Arg Phe Ser
His Glu Ser Asn Asp Glu Ile His Leu Ser Ser 965 970 975 Val Ile Ser
Thr Thr Pro Pro Asn Leu 980 985 11 2976 DNA homo sapiens 11
atgtctgaaa ataaacggat cgaggttctt tctaacggct ctttatacat cagtgaggtg
60 gaaggcaggc gaggagagca gtccgatgaa ggattttatc agtgcttggc
aatgaacaaa 120 tatggagcca ttcttagtca aaaagctcat cttgccttat
caactatttc tgcatttgaa 180 gtccagccaa tttccactga ggtccacgaa
ggtggagttg ctcgatttgc atgcaagatt 240 tcatcccacc ctcctgcagt
cataacatgg gagttcaatc ggacaactct acctatgact 300 atggacagga
taactgccct accaacagga gtattgcaga tctatgatgt cagccaaagg 360
gattctggaa attatcgttg tattgctgcc actgtagccc accgacgtaa aagtatggag
420 gcctcgctaa ctgtgattcc agctaaggag tcaaaatcct tccacacacc
arcaattata 480 gcaggtccac agaacataac aacatctctt catcagactg
tagttttgga atgcatggcc 540 acaggaaatc ccaaaccaat catttcttgg
agccgccttg atcacaaatc cattgatgtc 600 tttaatactc gggtacttgg
aaatggtaat ctcatgatat ctgatgtcag gctacaacat 660 gctggagtat
atgtttgtcg ggccactacc cctggcacac gcaactttac agttgctatg 720
gcaactttaa ctgtattagc tcctccttca tttgttgaat ggccagaaag tttaacaagg
780 cctcgagctg gcactgctcg atttgtgtgt caggcagaag gaatcccctc
tcccaagatg 840 tcatggttga aaaatggaag gaagatacat tcgaatggta
gaattaaaat gtacaacagt 900 aaattggtaa ttaaccagat tattcctgaa
gatgatgcta tttatcagtg catggctgag 960 aatagccaag gatctatttt
atctagagcc agactgactg tagtgatgtc agaagacaga 1020 cccagtgctc
cctataatgt acatgctgaa accatgtcaa gctcagccat tcttttagcc 1080
tgggagaggc cactttataa ttcagacaaa gtcattgcct attctgtaca ctacatgaaa
1140 gcagaaggtt taaataatga agagtatcaa gtagtcatcg gaaatgacac
aactcattat 1200 attattgatg acttagagcc tgccagcaat tatactttct
acattgtagc atatatgcca 1260 atgggagcca gccagatgtc tgaccatgtg
acacagaata ctctagagga tgttcccctg 1320 agacctcctg aaattagttt
gacaagtcga agtcccactg atattctcat ctcctggctg 1380 ccaatcccag
ccaaatatcg gcggggccaa gtggtgctgt atcgcttgtc tttccgccta 1440
agtactgaga attcaatcca agttctggag ctcccgggga ccacgcatga gtaccttttg
1500 gaaggcctga aacctgacag tgtctacctg gttcggatta ctgctgccac
cagagtgggg 1560 ctgggagagt catcagtatg gacttcacat aggacgccca
aagctacaag cgtgaaagcc 1620 cctaagtctc cagagttgca tttggagcct
ctgaactgta ccaccatttc tgtgaggtgg 1680 cagcaagatg tagaggacac
agctgctatt cagggctaca agctgtacta caaggaagaa 1740 gggcagcagg
agaatgggcc cattttcttg gataccaagg acctactcta tactctcagt 1800
ggcttagacc ccagaagaaa atatcatgtg agactcctgg cttacaacaa catagacgat
1860 ggctatcagg cagatcagac tgtcagcact ccaggatgcg tgtctgttcg
tgatcgcatg 1920 gtccctcctc caccaccacc ccaccatctc tatgcgaagg
ctaacacctc atcttccatc 1980 ttcctgcact ggaggaggcc tgcattcacc
gctgcacaaa tcattaacta caccatccgc 2040 tgtaatcctg ttggcctgca
gaatgcttct ttggttctgt accttcaaac atcagaaact 2100 cacatgttgg
ttcaaggtct agaaccaaac accaaatacg aatttgccgt tcgattacat 2160
gtggatcagc tttccagtcc ttggagccct gtagtctacc attctactct tccagaagca
2220 ccagcaggcc caccagttgg agtaaaagtg acattaatag aggatgacac
tgccctggtt 2280 tcttggaaac cccctgatgg cccagaaaca gttgtgaccc
gctatactat cttatatgca 2340 tctaggaagg cctggattgc aggagagtgg
caggtcttac accgtgaagg ggcaataacc 2400 atggctttgc tagaaaactt
ggtagcagga aatgtgtaca ttgtcaagat atctgcatcc 2460 aatgaggtgg
gagaaggacc cttttcaaat tctgtggagc tggcagtact tccaaaggaa 2520
acctctgaat caaatcagag gcccaagcgt ttagattctg ctgatgccaa agtttattca
2580 ggatattacc atctggacca aaaatcaatg actggcattg ctgtaggtgt
tggcatagcc 2640 ttgacctgca tcctcatctg tgttctcatc ttgatatacc
gaagtaaagc caggaaatca 2700 tctgcttcca agacggcaca gaatggaact
caacagttac ctcgtaccag tgcctcctta 2760 gctagtggaa atgaggtagg
aaagaacctg gaaggagctg taggaaatga agaatcttta 2820 atgccaatga
tcatgccaaa cagcttcatt gatgcaaagg tactgagctg cgggatttgc 2880
tgcataagcc gttcttccat tcctcctccc tgtgtgtgta aaatgtactt cccccaaaat
2940 tgtatgttga atgtattata ccaatactct tattaa 2976 12 991 PRT homo
sapiens 12 Met Ser Glu Asn Lys Arg Ile Glu Val Leu Ser Asn Gly Ser
Leu Tyr 1 5 10 15 Ile Ser Glu Val Glu Gly Arg Arg Gly Glu Gln Ser
Asp Glu Gly Phe 20 25 30 Tyr Gln Cys Leu Ala Met Asn Lys Tyr Gly
Ala Ile Leu Ser Gln Lys 35 40 45 Ala His Leu Ala Leu Ser Thr Ile
Ser Ala Phe Glu Val Gln Pro Ile 50 55 60 Ser Thr Glu Val His Glu
Gly Gly Val Ala Arg Phe Ala Cys Lys Ile 65 70 75 80 Ser Ser His Pro
Pro Ala Val Ile Thr Trp Glu Phe Asn Arg Thr Thr 85 90 95 Leu Pro
Met Thr Met Asp Arg
Ile Thr Ala Leu Pro Thr Gly Val Leu 100 105 110 Gln Ile Tyr Asp Val
Ser Gln Arg Asp Ser Gly Asn Tyr Arg Cys Ile 115 120 125 Ala Ala Thr
Val Ala His Arg Arg Lys Ser Met Glu Ala Ser Leu Thr 130 135 140 Val
Ile Pro Ala Lys Glu Ser Lys Ser Phe His Thr Pro Thr Ile Ile 145 150
155 160 Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu His Gln Thr Val Val
Leu 165 170 175 Glu Cys Met Ala Thr Gly Asn Pro Lys Pro Ile Ile Ser
Trp Ser Arg 180 185 190 Leu Asp His Lys Ser Ile Asp Val Phe Asn Thr
Arg Val Leu Gly Asn 195 200 205 Gly Asn Leu Met Ile Ser Asp Val Arg
Leu Gln His Ala Gly Val Tyr 210 215 220 Val Cys Arg Ala Thr Thr Pro
Gly Thr Arg Asn Phe Thr Val Ala Met 225 230 235 240 Ala Thr Leu Thr
Val Leu Ala Pro Pro Ser Phe Val Glu Trp Pro Glu 245 250 255 Ser Leu
Thr Arg Pro Arg Ala Gly Thr Ala Arg Phe Val Cys Gln Ala 260 265 270
Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu Lys Asn Gly Arg Lys 275
280 285 Ile His Ser Asn Gly Arg Ile Lys Met Tyr Asn Ser Lys Leu Val
Ile 290 295 300 Asn Gln Ile Ile Pro Glu Asp Asp Ala Ile Tyr Gln Cys
Met Ala Glu 305 310 315 320 Asn Ser Gln Gly Ser Ile Leu Ser Arg Ala
Arg Leu Thr Val Val Met 325 330 335 Ser Glu Asp Arg Pro Ser Ala Pro
Tyr Asn Val His Ala Glu Thr Met 340 345 350 Ser Ser Ser Ala Ile Leu
Leu Ala Trp Glu Arg Pro Leu Tyr Asn Ser 355 360 365 Asp Lys Val Ile
Ala Tyr Ser Val His Tyr Met Lys Ala Glu Gly Leu 370 375 380 Asn Asn
Glu Glu Tyr Gln Val Val Ile Gly Asn Asp Thr Thr His Tyr 385 390 395
400 Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr Thr Phe Tyr Ile Val
405 410 415 Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser Asp His Val
Thr Gln 420 425 430 Asn Thr Leu Glu Asp Val Pro Leu Arg Pro Pro Glu
Ile Ser Leu Thr 435 440 445 Ser Arg Ser Pro Thr Asp Ile Leu Ile Ser
Trp Leu Pro Ile Pro Ala 450 455 460 Lys Tyr Arg Arg Gly Gln Val Val
Leu Tyr Arg Leu Ser Phe Arg Leu 465 470 475 480 Ser Thr Glu Asn Ser
Ile Gln Val Leu Glu Leu Pro Gly Thr Thr His 485 490 495 Glu Tyr Leu
Leu Glu Gly Leu Lys Pro Asp Ser Val Tyr Leu Val Arg 500 505 510 Ile
Thr Ala Ala Thr Arg Val Gly Leu Gly Glu Ser Ser Val Trp Thr 515 520
525 Ser His Arg Thr Pro Lys Ala Thr Ser Val Lys Ala Pro Lys Ser Pro
530 535 540 Glu Leu His Leu Glu Pro Leu Asn Cys Thr Thr Ile Ser Val
Arg Trp 545 550 555 560 Gln Gln Asp Val Glu Asp Thr Ala Ala Ile Gln
Gly Tyr Lys Leu Tyr 565 570 575 Tyr Lys Glu Glu Gly Gln Gln Glu Asn
Gly Pro Ile Phe Leu Asp Thr 580 585 590 Lys Asp Leu Leu Tyr Thr Leu
Ser Gly Leu Asp Pro Arg Arg Lys Tyr 595 600 605 His Val Arg Leu Leu
Ala Tyr Asn Asn Ile Asp Asp Gly Tyr Gln Ala 610 615 620 Asp Gln Thr
Val Ser Thr Pro Gly Cys Val Ser Val Arg Asp Arg Met 625 630 635 640
Val Pro Pro Pro Pro Pro Pro His His Leu Tyr Ala Lys Ala Asn Thr 645
650 655 Ser Ser Ser Ile Phe Leu His Trp Arg Arg Pro Ala Phe Thr Ala
Ala 660 665 670 Gln Ile Ile Asn Tyr Thr Ile Arg Cys Asn Pro Val Gly
Leu Gln Asn 675 680 685 Ala Ser Leu Val Leu Tyr Leu Gln Thr Ser Glu
Thr His Met Leu Val 690 695 700 Gln Gly Leu Glu Pro Asn Thr Lys Tyr
Glu Phe Ala Val Arg Leu His 705 710 715 720 Val Asp Gln Leu Ser Ser
Pro Trp Ser Pro Val Val Tyr His Ser Thr 725 730 735 Leu Pro Glu Ala
Pro Ala Gly Pro Pro Val Gly Val Lys Val Thr Leu 740 745 750 Ile Glu
Asp Asp Thr Ala Leu Val Ser Trp Lys Pro Pro Asp Gly Pro 755 760 765
Glu Thr Val Val Thr Arg Tyr Thr Ile Leu Tyr Ala Ser Arg Lys Ala 770
775 780 Trp Ile Ala Gly Glu Trp Gln Val Leu His Arg Glu Gly Ala Ile
Thr 785 790 795 800 Met Ala Leu Leu Glu Asn Leu Val Ala Gly Asn Val
Tyr Ile Val Lys 805 810 815 Ile Ser Ala Ser Asn Glu Val Gly Glu Gly
Pro Phe Ser Asn Ser Val 820 825 830 Glu Leu Ala Val Leu Pro Lys Glu
Thr Ser Glu Ser Asn Gln Arg Pro 835 840 845 Lys Arg Leu Asp Ser Ala
Asp Ala Lys Val Tyr Ser Gly Tyr Tyr His 850 855 860 Leu Asp Gln Lys
Ser Met Thr Gly Ile Ala Val Gly Val Gly Ile Ala 865 870 875 880 Leu
Thr Cys Ile Leu Ile Cys Val Leu Ile Leu Ile Tyr Arg Ser Lys 885 890
895 Ala Arg Lys Ser Ser Ala Ser Lys Thr Ala Gln Asn Gly Thr Gln Gln
900 905 910 Leu Pro Arg Thr Ser Ala Ser Leu Ala Ser Gly Asn Glu Val
Gly Lys 915 920 925 Asn Leu Glu Gly Ala Val Gly Asn Glu Glu Ser Leu
Met Pro Met Ile 930 935 940 Met Pro Asn Ser Phe Ile Asp Ala Lys Val
Leu Ser Cys Gly Ile Cys 945 950 955 960 Cys Ile Ser Arg Ser Ser Ile
Pro Pro Pro Cys Val Cys Lys Met Tyr 965 970 975 Phe Pro Gln Asn Cys
Met Leu Asn Val Leu Tyr Gln Tyr Ser Tyr 980 985 990 13 909 DNA homo
sapiens 13 atgtctgaaa ataaacggat cgaggttctt tctaacggct ctttatacat
cagtgaggtg 60 gaaggcaggc gaggagagca gtccgatgaa ggattttatc
agtgcttggc aatgaacaaa 120 tatggagcca ttcttagtca aaaagctcat
cttgccttat caactatttc tgcatttgaa 180 gtccagccaa tttccactga
ggtccacgaa ggtggagttg ctcgatttgc atgcaagatt 240 tcatcccacc
ctcctgcagt cataacatgg gagttcaatc ggacaactct acctatgact 300
atggacagga taactgccct accaacagga gtattgcaga tctatgatgt cagccaaagg
360 gattctggaa attatcgttg tattgctgcc actgtagccc accgacgtaa
aagtatggag 420 gcctcgctaa ctgtgattcc agctaaggag tcaaaatcct
tccacacacc arcaattata 480 gcaggtccac agaacataac aacatctctt
catcagactg tagttttgga atgcatggcc 540 acaggaaatc ccaaaccaat
catttcttgg agccgccttg atcacaaatc cattgatgtc 600 tttaatactc
gggtacttgg aaatggtaat ctcatgatat ctgatgtcag gctacaacat 660
gctggagtat atgtttgtcg ggccactacc cctggcacac gcaactttac agttgctatg
720 gcaactttaa ctgtattagc tcctccttca tttgttgaat ggccagaaag
tttaacaagg 780 cctcgagctg gcactgctcg atttgtgtgt caggcagaag
gaatcccctc tcccaagatg 840 tcatggttga aaaatggaag gaagatacat
tcgaatggta gaattaaaat gtacaacagg 900 tttaaataa 909 14 302 PRT homo
sapiens 14 Met Ser Glu Asn Lys Arg Ile Glu Val Leu Ser Asn Gly Ser
Leu Tyr 1 5 10 15 Ile Ser Glu Val Glu Gly Arg Arg Gly Glu Gln Ser
Asp Glu Gly Phe 20 25 30 Tyr Gln Cys Leu Ala Met Asn Lys Tyr Gly
Ala Ile Leu Ser Gln Lys 35 40 45 Ala His Leu Ala Leu Ser Thr Ile
Ser Ala Phe Glu Val Gln Pro Ile 50 55 60 Ser Thr Glu Val His Glu
Gly Gly Val Ala Arg Phe Ala Cys Lys Ile 65 70 75 80 Ser Ser His Pro
Pro Ala Val Ile Thr Trp Glu Phe Asn Arg Thr Thr 85 90 95 Leu Pro
Met Thr Met Asp Arg Ile Thr Ala Leu Pro Thr Gly Val Leu 100 105 110
Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly Asn Tyr Arg Cys Ile 115
120 125 Ala Ala Thr Val Ala His Arg Arg Lys Ser Met Glu Ala Ser Leu
Thr 130 135 140 Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His Thr Pro
Thr Ile Ile 145 150 155 160 Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu
His Gln Thr Val Val Leu 165 170 175 Glu Cys Met Ala Thr Gly Asn Pro
Lys Pro Ile Ile Ser Trp Ser Arg 180 185 190 Leu Asp His Lys Ser Ile
Asp Val Phe Asn Thr Arg Val Leu Gly Asn 195 200 205 Gly Asn Leu Met
Ile Ser Asp Val Arg Leu Gln His Ala Gly Val Tyr 210 215 220 Val Cys
Arg Ala Thr Thr Pro Gly Thr Arg Asn Phe Thr Val Ala Met 225 230 235
240 Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe Val Glu Trp Pro Glu
245 250 255 Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala Arg Phe Val Cys
Gln Ala 260 265 270 Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu Lys
Asn Gly Arg Lys 275 280 285 Ile His Ser Asn Gly Arg Ile Lys Met Tyr
Asn Arg Phe Lys 290 295 300 15 2481 DNA homo sapiens 15 atgtctgaaa
ataaacggat cgaggttctt tctaacggct ctttatacat cagtgaggtg 60
gaaggcaggc gaggagagca gtccgatgaa ggattttatc agtgcttggc aatgaacaaa
120 tatggagcca ttcttagtca aaaagctcat cttgccttat caactatttc
tgcatttgaa 180 gtccagccaa tttccactga ggtccacgaa ggtggagttg
ctcgatttgc atgcaagatt 240 tcatcccacc ctcctgcagt cataacatgg
gagttcaatc ggacaactct acctatgact 300 atggacagga taactgccct
accaacagga gtattgcaga tctatgatgt cagccaaagg 360 gattctggaa
attatcgttg tattgctgcc actgtagccc accgacgtaa aagtatggag 420
gcctcgctaa ctgtgattcc agctaaggag tcaaaatcct tccacacacc arcaattata
480 gcaggtccac agaacataac aacatctctt catcagactg tagttttgga
atgcatggcc 540 acaggaaatc ccaaaccaat catttcttgg agccgccttg
atcacaaatc cattgatgtc 600 tttaatactc gggtacttgg aaatggtaat
ctcatgatat ctgatgtcag gctacaacat 660 gctggagtat atgtttgtcg
ggccactacc cctggcacac gcaactttac agttgctatg 720 gcaactttaa
ctgtattagc tcctccttca tttgttgaat ggccagaaag tttaacaagg 780
cctcgagctg gcactgctcg atttgtgtgt caggcagaag gaatcccctc tcccaagatg
840 tcatggttga aaaatggaag gaagatacat tcgaatggta gaattaaaat
gtacaacagt 900 aaattggtaa ttaaccagat tattcctgaa gatgatgcta
tttatcagtg catggctgag 960 aatagccaag gatctatttt atctagagcc
agactgactg tagtgatgtc agaagacaga 1020 cccagtgctc cctataatgt
acatgctgaa accatgtcaa gctcagccat tcttttagcc 1080 tgggagaggc
cactttataa ttcagacaaa gtcattgcct attctgtaca ctacatgaaa 1140
gcagaaggtt taaataatga agagtatcaa gtagtcatcg gaaatgacac aactcattat
1200 attattgatg acttagagcc tgccagcaat tatactttct acattgtagc
atatatgcca 1260 atgggagcca gccagatgtc tgaccatgtg acacagaata
ctctagagga tgaccccaga 1320 agaaaatatc atgtgagact cctggcttac
aacaacatag acgatggcta tcaggcagat 1380 cagactgtca gcactccagg
atgcgtgtct gttcgtgatc gcatggtccc tcctccacca 1440 ccaccccacc
atctctatgc gaaggctaac acctcatctt ccatcttcct gcactggagg 1500
aggcctgcat tcaccgctgc acaaatcatt aactacacca tccgctgtaa tcctgttggc
1560 ctgcagaatg cttctttggt tctgtacctt caaacatcag aaactcacat
gttggttcaa 1620 ggtctagaac caaacaccaa atacgaattt gccgttcgat
tacatgtgga tcagctttcc 1680 agtccttgga gccctgtagt ctaccattct
actcttccag aagcaccagc aggcccacca 1740 gttggagtaa aagtgacatt
aatagaggat gacactgccc tggtttcttg gaaaccccct 1800 gatggcccag
aaacagttgt gacccgctat actatcttat atgcatctag gaaggcctgg 1860
attgcaggag agtggcaggt cttacaccgt gaaggggcaa taaccatggc tttgctagaa
1920 aacttggtag caggaaatgt gtacattgtc aagatatctg catccaatga
ggtgggagaa 1980 ggaccctttt caaattctgt ggagctggca gtacttccaa
aggaaacctc tgaatcaaat 2040 cagaggccca agcgtttaga ttctgctgat
gccaaagttt attcaggata ttaccatctg 2100 gaccaaaaat caatgactgg
cattgctgta ggtgttggca tagccttgac ctgcatcctc 2160 atctgtgttc
tcatcttgat ataccgaagt aaagccagga aatcatctgc ttccaagacg 2220
gcacagaatg gaactcaaca gttacctcgt accagtgcct ccttagctag tggaaatgag
2280 gtaggaaaga acctggaagg agctgtagga aatgaagaat ctttaatgcc
aatgatcatg 2340 ccaaacagct tcattgatgc aaaggtactg agctgcggga
tttgctgcat aagccgttct 2400 tccattcctc ctccctgtgt gtgtaaaatg
tacttccccc aaaattgtat gttgaatgta 2460 ttataccaat actcttatta a 2481
16 826 PRT homo sapiens 16 Met Ser Glu Asn Lys Arg Ile Glu Val Leu
Ser Asn Gly Ser Leu Tyr 1 5 10 15 Ile Ser Glu Val Glu Gly Arg Arg
Gly Glu Gln Ser Asp Glu Gly Phe 20 25 30 Tyr Gln Cys Leu Ala Met
Asn Lys Tyr Gly Ala Ile Leu Ser Gln Lys 35 40 45 Ala His Leu Ala
Leu Ser Thr Ile Ser Ala Phe Glu Val Gln Pro Ile 50 55 60 Ser Thr
Glu Val His Glu Gly Gly Val Ala Arg Phe Ala Cys Lys Ile 65 70 75 80
Ser Ser His Pro Pro Ala Val Ile Thr Trp Glu Phe Asn Arg Thr Thr 85
90 95 Leu Pro Met Thr Met Asp Arg Ile Thr Ala Leu Pro Thr Gly Val
Leu 100 105 110 Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly Asn Tyr
Arg Cys Ile 115 120 125 Ala Ala Thr Val Ala His Arg Arg Lys Ser Met
Glu Ala Ser Leu Thr 130 135 140 Val Ile Pro Ala Lys Glu Ser Lys Ser
Phe His Thr Pro Thr Ile Ile 145 150 155 160 Ala Gly Pro Gln Asn Ile
Thr Thr Ser Leu His Gln Thr Val Val Leu 165 170 175 Glu Cys Met Ala
Thr Gly Asn Pro Lys Pro Ile Ile Ser Trp Ser Arg 180 185 190 Leu Asp
His Lys Ser Ile Asp Val Phe Asn Thr Arg Val Leu Gly Asn 195 200 205
Gly Asn Leu Met Ile Ser Asp Val Arg Leu Gln His Ala Gly Val Tyr 210
215 220 Val Cys Arg Ala Thr Thr Pro Gly Thr Arg Asn Phe Thr Val Ala
Met 225 230 235 240 Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe Val
Glu Trp Pro Glu 245 250 255 Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala
Arg Phe Val Cys Gln Ala 260 265 270 Glu Gly Ile Pro Ser Pro Lys Met
Ser Trp Leu Lys Asn Gly Arg Lys 275 280 285 Ile His Ser Asn Gly Arg
Ile Lys Met Tyr Asn Ser Lys Leu Val Ile 290 295 300 Asn Gln Ile Ile
Pro Glu Asp Asp Ala Ile Tyr Gln Cys Met Ala Glu 305 310 315 320 Asn
Ser Gln Gly Ser Ile Leu Ser Arg Ala Arg Leu Thr Val Val Met 325 330
335 Ser Glu Asp Arg Pro Ser Ala Pro Tyr Asn Val His Ala Glu Thr Met
340 345 350 Ser Ser Ser Ala Ile Leu Leu Ala Trp Glu Arg Pro Leu Tyr
Asn Ser 355 360 365 Asp Lys Val Ile Ala Tyr Ser Val His Tyr Met Lys
Ala Glu Gly Leu 370 375 380 Asn Asn Glu Glu Tyr Gln Val Val Ile Gly
Asn Asp Thr Thr His Tyr 385 390 395 400 Ile Ile Asp Asp Leu Glu Pro
Ala Ser Asn Tyr Thr Phe Tyr Ile Val 405 410 415 Ala Tyr Met Pro Met
Gly Ala Ser Gln Met Ser Asp His Val Thr Gln 420 425 430 Asn Thr Leu
Glu Asp Asp Pro Arg Arg Lys Tyr His Val Arg Leu Leu 435 440 445 Ala
Tyr Asn Asn Ile Asp Asp Gly Tyr Gln Ala Asp Gln Thr Val Ser 450 455
460 Thr Pro Gly Cys Val Ser Val Arg Asp Arg Met Val Pro Pro Pro Pro
465 470 475 480 Pro Pro His His Leu Tyr Ala Lys Ala Asn Thr Ser Ser
Ser Ile Phe 485 490 495 Leu His Trp Arg Arg Pro Ala Phe Thr Ala Ala
Gln Ile Ile Asn Tyr 500 505 510 Thr Ile Arg Cys Asn Pro Val Gly Leu
Gln Asn Ala Ser Leu Val Leu 515 520 525 Tyr Leu Gln Thr Ser Glu Thr
His Met Leu Val Gln Gly Leu Glu Pro 530 535 540 Asn Thr Lys Tyr Glu
Phe Ala Val Arg Leu His Val Asp Gln Leu Ser 545 550 555 560 Ser Pro
Trp Ser Pro Val Val Tyr His Ser Thr Leu Pro Glu Ala Pro 565 570 575
Ala Gly Pro Pro Val Gly Val Lys Val Thr Leu Ile Glu Asp Asp Thr 580
585 590 Ala Leu Val Ser Trp Lys Pro Pro Asp Gly Pro Glu Thr Val Val
Thr 595 600 605 Arg Tyr Thr Ile Leu Tyr Ala Ser Arg Lys Ala Trp Ile
Ala Gly Glu 610 615 620 Trp Gln Val Leu His Arg Glu Gly Ala Ile Thr
Met Ala Leu Leu Glu 625 630 635 640 Asn Leu Val Ala Gly Asn Val Tyr
Ile Val Lys Ile Ser Ala Ser Asn 645 650 655 Glu Val Gly Glu Gly Pro
Phe Ser Asn Ser Val Glu Leu Ala Val Leu 660 665 670
Pro Lys Glu Thr Ser Glu Ser Asn Gln Arg Pro Lys Arg Leu Asp Ser 675
680 685 Ala Asp Ala Lys Val Tyr Ser Gly Tyr Tyr His Leu Asp Gln Lys
Ser 690 695 700 Met Thr Gly Ile Ala Val Gly Val Gly Ile Ala Leu Thr
Cys Ile Leu 705 710 715 720 Ile Cys Val Leu Ile Leu Ile Tyr Arg Ser
Lys Ala Arg Lys Ser Ser 725 730 735 Ala Ser Lys Thr Ala Gln Asn Gly
Thr Gln Gln Leu Pro Arg Thr Ser 740 745 750 Ala Ser Leu Ala Ser Gly
Asn Glu Val Gly Lys Asn Leu Glu Gly Ala 755 760 765 Val Gly Asn Glu
Glu Ser Leu Met Pro Met Ile Met Pro Asn Ser Phe 770 775 780 Ile Asp
Ala Lys Val Leu Ser Cys Gly Ile Cys Cys Ile Ser Arg Ser 785 790 795
800 Ser Ile Pro Pro Pro Cys Val Cys Lys Met Tyr Phe Pro Gln Asn Cys
805 810 815 Met Leu Asn Val Leu Tyr Gln Tyr Ser Tyr 820 825 17 3219
DNA homo sapiens 17 atgtctgaaa ataaacggat cgaggttctt tctaacggct
ctttatacat cagtgaggtg 60 gaaggcaggc gaggagagca gtccgatgaa
ggattttatc agtgcttggc aatgaacaaa 120 tatggagcca ttcttagtca
aaaagctcat cttgccttat caactatttc tgcatttgaa 180 gtccagccaa
tttccactga ggtccacgaa ggtggagttg ctcgatttgc atgcaagatt 240
tcatcccacc ctcctgcagt cataacatgg gagttcaatc ggacaactct acctatgact
300 atggacagga taactgccct accaacagga gtattgcaga tctatgatgt
cagccaaagg 360 gattctggaa attatcgttg tattgctgcc actgtagccc
accgacgtaa aagtatggag 420 gcctcgctaa ctgtgattcc agctaaggag
tcaaaatcct tccacacacc arcaattata 480 gcaggtccac agaacataac
aacatctctt catcagactg tagttttgga atgcatggcc 540 acaggaaatc
ccaaaccaat catttcttgg agccgccttg atcacaaatc cattgatgtc 600
tttaatactc gggtacttgg aaatggtaat ctcatgatat ctgatgtcag gctacaacat
660 gctggagtat atgtttgtcg ggccactacc cctggcacac gcaactttac
agttgctatg 720 gcaactttaa ctgtattagc tcctccttca tttgttgaat
ggccagaaag tttaacaagg 780 cctcgagctg gcactgctcg atttgtgtgt
caggcagaag gaatcccctc tcccaagatg 840 tcatggttga aaaatggaag
gaagatacat tcgaatggta gaattaaaat gtacaacagt 900 aaattggtaa
ttaaccagat tattcctgaa gatgatgcta tttatcagtg catggctgag 960
aatagccaag gatctatttt atctagagcc agactgactg tagtgatgtc agaagacaga
1020 cccagtgctc cctataatgt acatgctgaa accatgtcaa gctcagccat
tcttttagcc 1080 tgggagaggc cactttataa ttcagacaaa gtcattgcct
attctgtaca ctacatgaaa 1140 gcagaaggtt taaataatga agagtatcaa
gtagtcatcg gaaatgacac aactcattat 1200 attattgatg acttagagcc
tgccagcaat tatactttct acattgtagc atatatgcca 1260 atgggagcca
gccagatgtc tgaccatgtg acacagaata ctctagagga tgttcccctg 1320
agacctcctg aaattagttt gacaagtcga agtcccactg atattctcat ctcctggctg
1380 ccaatcccag ccaaatatcg gcggggccaa gtggtgctgt atcgcttgtc
tttccgccta 1440 agtactgaga attcaatcca agttctggag ctcccgggga
ccacgcatga gtaccttttg 1500 gaaggcctga aacctgacag tgtctacctg
gttcggatta ctgctgccac cagagtgggg 1560 ctgggagagt catcagtatg
gacttcacat aggacgccca aagctacaag cgtgaaagcc 1620 cctaagtctc
cagagttgca tttggagcct ctgaactgta ccaccatttc tgtgaggtgg 1680
cagcaagatg tagaggacac agctgctatt cagggctaca agctgtacta caaggaagaa
1740 gggcagcagg agaatgggcc cattttcttg gataccaagg acctactcta
tactctcagt 1800 ggcttagacc ccagaagaaa atatcatgtg agactcctgg
cttacaacaa catagacgat 1860 ggctatcagg cagatcagac tgtcagcact
ccaggatgcg tgtctgttcg tgatcgcatg 1920 gtccctcctc caccaccacc
ccaccatctc tatgcgaagg ctaacacctc atcttccatc 1980 ttcctgcact
ggaggaggcc tgcattcacc gctgcacaaa tcattaacta caccatccgc 2040
tgtaatcctg ttggcctgca gaatgcttct ttggttctgt accttcaaac atcagaaact
2100 cacatgttgg ttcaaggtct agaaccaaac accaaatacg aatttgccgt
tcgattacat 2160 gtggatcagc tttccagtcc ttggagccct gtagtctacc
attctactct tccagaagca 2220 ccagcaggcc caccagttgg agtaaaagtg
acattaatag aggatgacac tgccctggtt 2280 tcttggaaac cccctgatgg
cccagaaaca gttgtgaccc gctatactat cttatatgca 2340 tctaggaagg
cctggattgc aggagagtgg caggtcttac accgtgaagg ggcaataacc 2400
atggctttgc tagaaaactt ggtagcagga aatgtgtaca ttgtcaagat atctgcatcc
2460 aatgaggtgg gagaaggacc cttttcaaat tctgtggagc tggcagtact
tccaaaggaa 2520 acctctgaat caaatcagag gcccaagcgt ttagattctg
ctgatgccaa agtttattca 2580 ggatattacc atctggacca aaaatcaatg
actggcattg ctgtaggtgt tggcatagcc 2640 ttgacctgca tcctcatctg
tgttctcatc ttgatatacc gaagtaaagc caggaaatca 2700 tctgcttcca
agacggcaca gaatggaact caacagttac ctcgtaccag tgcctcctta 2760
gctagtggaa atgaggtagg aaagaacctg gaaggagctg taggaaatga agaatcttta
2820 atgccaatga tcatgccaaa cagcttcatt gatgcaaagg gaggaactga
cctgataatt 2880 aatagctatg gtcctataat taaaaacaac tctaagaaaa
agtggttttt tttccaagac 2940 tcaaagaaga tacaagttga gcagcctcaa
agaagattta ctccagcggt ctgcttttac 3000 cagccaggca ccactgtatt
aatcagtgat gaagactccc ctagctcccc aggtcagaca 3060 accagcttct
caagaccctt tggtgttgca gctgatacag aacattcagc aaatagtgaa 3120
ggcagccatg agactgggga ttctgggcgg ttttctcatg agtccaacga tgagatacat
3180 ctgtcctcag ttataagtac cacacccccc aacctctga 3219 18 1072 PRT
homo sapiens 18 Met Ser Glu Asn Lys Arg Ile Glu Val Leu Ser Asn Gly
Ser Leu Tyr 1 5 10 15 Ile Ser Glu Val Glu Gly Arg Arg Gly Glu Gln
Ser Asp Glu Gly Phe 20 25 30 Tyr Gln Cys Leu Ala Met Asn Lys Tyr
Gly Ala Ile Leu Ser Gln Lys 35 40 45 Ala His Leu Ala Leu Ser Thr
Ile Ser Ala Phe Glu Val Gln Pro Ile 50 55 60 Ser Thr Glu Val His
Glu Gly Gly Val Ala Arg Phe Ala Cys Lys Ile 65 70 75 80 Ser Ser His
Pro Pro Ala Val Ile Thr Trp Glu Phe Asn Arg Thr Thr 85 90 95 Leu
Pro Met Thr Met Asp Arg Ile Thr Ala Leu Pro Thr Gly Val Leu 100 105
110 Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly Asn Tyr Arg Cys Ile
115 120 125 Ala Ala Thr Val Ala His Arg Arg Lys Ser Met Glu Ala Ser
Leu Thr 130 135 140 Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His Thr
Pro Thr Ile Ile 145 150 155 160 Ala Gly Pro Gln Asn Ile Thr Thr Ser
Leu His Gln Thr Val Val Leu 165 170 175 Glu Cys Met Ala Thr Gly Asn
Pro Lys Pro Ile Ile Ser Trp Ser Arg 180 185 190 Leu Asp His Lys Ser
Ile Asp Val Phe Asn Thr Arg Val Leu Gly Asn 195 200 205 Gly Asn Leu
Met Ile Ser Asp Val Arg Leu Gln His Ala Gly Val Tyr 210 215 220 Val
Cys Arg Ala Thr Thr Pro Gly Thr Arg Asn Phe Thr Val Ala Met 225 230
235 240 Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe Val Glu Trp Pro
Glu 245 250 255 Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala Arg Phe Val
Cys Gln Ala 260 265 270 Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu
Lys Asn Gly Arg Lys 275 280 285 Ile His Ser Asn Gly Arg Ile Lys Met
Tyr Asn Ser Lys Leu Val Ile 290 295 300 Asn Gln Ile Ile Pro Glu Asp
Asp Ala Ile Tyr Gln Cys Met Ala Glu 305 310 315 320 Asn Ser Gln Gly
Ser Ile Leu Ser Arg Ala Arg Leu Thr Val Val Met 325 330 335 Ser Glu
Asp Arg Pro Ser Ala Pro Tyr Asn Val His Ala Glu Thr Met 340 345 350
Ser Ser Ser Ala Ile Leu Leu Ala Trp Glu Arg Pro Leu Tyr Asn Ser 355
360 365 Asp Lys Val Ile Ala Tyr Ser Val His Tyr Met Lys Ala Glu Gly
Leu 370 375 380 Asn Asn Glu Glu Tyr Gln Val Val Ile Gly Asn Asp Thr
Thr His Tyr 385 390 395 400 Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn
Tyr Thr Phe Tyr Ile Val 405 410 415 Ala Tyr Met Pro Met Gly Ala Ser
Gln Met Ser Asp His Val Thr Gln 420 425 430 Asn Thr Leu Glu Asp Val
Pro Leu Arg Pro Pro Glu Ile Ser Leu Thr 435 440 445 Ser Arg Ser Pro
Thr Asp Ile Leu Ile Ser Trp Leu Pro Ile Pro Ala 450 455 460 Lys Tyr
Arg Arg Gly Gln Val Val Leu Tyr Arg Leu Ser Phe Arg Leu 465 470 475
480 Ser Thr Glu Asn Ser Ile Gln Val Leu Glu Leu Pro Gly Thr Thr His
485 490 495 Glu Tyr Leu Leu Glu Gly Leu Lys Pro Asp Ser Val Tyr Leu
Val Arg 500 505 510 Ile Thr Ala Ala Thr Arg Val Gly Leu Gly Glu Ser
Ser Val Trp Thr 515 520 525 Ser His Arg Thr Pro Lys Ala Thr Ser Val
Lys Ala Pro Lys Ser Pro 530 535 540 Glu Leu His Leu Glu Pro Leu Asn
Cys Thr Thr Ile Ser Val Arg Trp 545 550 555 560 Gln Gln Asp Val Glu
Asp Thr Ala Ala Ile Gln Gly Tyr Lys Leu Tyr 565 570 575 Tyr Lys Glu
Glu Gly Gln Gln Glu Asn Gly Pro Ile Phe Leu Asp Thr 580 585 590 Lys
Asp Leu Leu Tyr Thr Leu Ser Gly Leu Asp Pro Arg Arg Lys Tyr 595 600
605 His Val Arg Leu Leu Ala Tyr Asn Asn Ile Asp Asp Gly Tyr Gln Ala
610 615 620 Asp Gln Thr Val Ser Thr Pro Gly Cys Val Ser Val Arg Asp
Arg Met 625 630 635 640 Val Pro Pro Pro Pro Pro Pro His His Leu Tyr
Ala Lys Ala Asn Thr 645 650 655 Ser Ser Ser Ile Phe Leu His Trp Arg
Arg Pro Ala Phe Thr Ala Ala 660 665 670 Gln Ile Ile Asn Tyr Thr Ile
Arg Cys Asn Pro Val Gly Leu Gln Asn 675 680 685 Ala Ser Leu Val Leu
Tyr Leu Gln Thr Ser Glu Thr His Met Leu Val 690 695 700 Gln Gly Leu
Glu Pro Asn Thr Lys Tyr Glu Phe Ala Val Arg Leu His 705 710 715 720
Val Asp Gln Leu Ser Ser Pro Trp Ser Pro Val Val Tyr His Ser Thr 725
730 735 Leu Pro Glu Ala Pro Ala Gly Pro Pro Val Gly Val Lys Val Thr
Leu 740 745 750 Ile Glu Asp Asp Thr Ala Leu Val Ser Trp Lys Pro Pro
Asp Gly Pro 755 760 765 Glu Thr Val Val Thr Arg Tyr Thr Ile Leu Tyr
Ala Ser Arg Lys Ala 770 775 780 Trp Ile Ala Gly Glu Trp Gln Val Leu
His Arg Glu Gly Ala Ile Thr 785 790 795 800 Met Ala Leu Leu Glu Asn
Leu Val Ala Gly Asn Val Tyr Ile Val Lys 805 810 815 Ile Ser Ala Ser
Asn Glu Val Gly Glu Gly Pro Phe Ser Asn Ser Val 820 825 830 Glu Leu
Ala Val Leu Pro Lys Glu Thr Ser Glu Ser Asn Gln Arg Pro 835 840 845
Lys Arg Leu Asp Ser Ala Asp Ala Lys Val Tyr Ser Gly Tyr Tyr His 850
855 860 Leu Asp Gln Lys Ser Met Thr Gly Ile Ala Val Gly Val Gly Ile
Ala 865 870 875 880 Leu Thr Cys Ile Leu Ile Cys Val Leu Ile Leu Ile
Tyr Arg Ser Lys 885 890 895 Ala Arg Lys Ser Ser Ala Ser Lys Thr Ala
Gln Asn Gly Thr Gln Gln 900 905 910 Leu Pro Arg Thr Ser Ala Ser Leu
Ala Ser Gly Asn Glu Val Gly Lys 915 920 925 Asn Leu Glu Gly Ala Val
Gly Asn Glu Glu Ser Leu Met Pro Met Ile 930 935 940 Met Pro Asn Ser
Phe Ile Asp Ala Lys Gly Gly Thr Asp Leu Ile Ile 945 950 955 960 Asn
Ser Tyr Gly Pro Ile Ile Lys Asn Asn Ser Lys Lys Lys Trp Phe 965 970
975 Phe Phe Gln Asp Ser Lys Lys Ile Gln Val Glu Gln Pro Gln Arg Arg
980 985 990 Phe Thr Pro Ala Val Cys Phe Tyr Gln Pro Gly Thr Thr Val
Leu Ile 995 1000 1005 Ser Asp Glu Asp Ser Pro Ser Ser Pro Gly Gln
Thr Thr Ser Phe Ser 1010 1015 1020 Arg Pro Phe Gly Val Ala Ala Asp
Thr Glu His Ser Ala Asn Ser Glu 1025 1030 1035 1040 Gly Ser His Glu
Thr Gly Asp Ser Gly Arg Phe Ser His Glu Ser Asn 1045 1050 1055 Asp
Glu Ile His Leu Ser Ser Val Ile Ser Thr Thr Pro Pro Asn Leu 1060
1065 1070 19 2724 DNA homo sapiens 19 atgtctgaaa ataaacggat
cgaggttctt tctaacggct ctttatacat cagtgaggtg 60 gaaggcaggc
gaggagagca gtccgatgaa ggattttatc agtgcttggc aatgaacaaa 120
tatggagcca ttcttagtca aaaagctcat cttgccttat caactatttc tgcatttgaa
180 gtccagccaa tttccactga ggtccacgaa ggtggagttg ctcgatttgc
atgcaagatt 240 tcatcccacc ctcctgcagt cataacatgg gagttcaatc
ggacaactct acctatgact 300 atggacagga taactgccct accaacagga
gtattgcaga tctatgatgt cagccaaagg 360 gattctggaa attatcgttg
tattgctgcc actgtagccc accgacgtaa aagtatggag 420 gcctcgctaa
ctgtgattcc agctaaggag tcaaaatcct tccacacacc arcaattata 480
gcaggtccac agaacataac aacatctctt catcagactg tagttttgga atgcatggcc
540 acaggaaatc ccaaaccaat catttcttgg agccgccttg atcacaaatc
cattgatgtc 600 tttaatactc gggtacttgg aaatggtaat ctcatgatat
ctgatgtcag gctacaacat 660 gctggagtat atgtttgtcg ggccactacc
cctggcacac gcaactttac agttgctatg 720 gcaactttaa ctgtattagc
tcctccttca tttgttgaat ggccagaaag tttaacaagg 780 cctcgagctg
gcactgctcg atttgtgtgt caggcagaag gaatcccctc tcccaagatg 840
tcatggttga aaaatggaag gaagatacat tcgaatggta gaattaaaat gtacaacagt
900 aaattggtaa ttaaccagat tattcctgaa gatgatgcta tttatcagtg
catggctgag 960 aatagccaag gatctatttt atctagagcc agactgactg
tagtgatgtc agaagacaga 1020 cccagtgctc cctataatgt acatgctgaa
accatgtcaa gctcagccat tcttttagcc 1080 tgggagaggc cactttataa
ttcagacaaa gtcattgcct attctgtaca ctacatgaaa 1140 gcagaaggtt
taaataatga agagtatcaa gtagtcatcg gaaatgacac aactcattat 1200
attattgatg acttagagcc tgccagcaat tatactttct acattgtagc atatatgcca
1260 atgggagcca gccagatgtc tgaccatgtg acacagaata ctctagagga
tgaccccaga 1320 agaaaatatc atgtgagact cctggcttac aacaacatag
acgatggcta tcaggcagat 1380 cagactgtca gcactccagg atgcgtgtct
gttcgtgatc gcatggtccc tcctccacca 1440 ccaccccacc atctctatgc
gaaggctaac acctcatctt ccatcttcct gcactggagg 1500 aggcctgcat
tcaccgctgc acaaatcatt aactacacca tccgctgtaa tcctgttggc 1560
ctgcagaatg cttctttggt tctgtacctt caaacatcag aaactcacat gttggttcaa
1620 ggtctagaac caaacaccaa atacgaattt gccgttcgat tacatgtgga
tcagctttcc 1680 agtccttgga gccctgtagt ctaccattct actcttccag
aagcaccagc aggcccacca 1740 gttggagtaa aagtgacatt aatagaggat
gacactgccc tggtttcttg gaaaccccct 1800 gatggcccag aaacagttgt
gacccgctat actatcttat atgcatctag gaaggcctgg 1860 attgcaggag
agtggcaggt cttacaccgt gaaggggcaa taaccatggc tttgctagaa 1920
aacttggtag caggaaatgt gtacattgtc aagatatctg catccaatga ggtgggagaa
1980 ggaccctttt caaattctgt ggagctggca gtacttccaa aggaaacctc
tgaatcaaat 2040 cagaggccca agcgtttaga ttctgctgat gccaaagttt
attcaggata ttaccatctg 2100 gaccaaaaat caatgactgg cattgctgta
ggtgttggca tagccttgac ctgcatcctc 2160 atctgtgttc tcatcttgat
ataccgaagt aaagccagga aatcatctgc ttccaagacg 2220 gcacagaatg
gaactcaaca gttacctcgt accagtgcct ccttagctag tggaaatgag 2280
gtaggaaaga acctggaagg agctgtagga aatgaagaat ctttaatgcc aatgatcatg
2340 ccaaacagct tcattgatgc aaagggagga actgacctga taattaatag
ctatggtcct 2400 ataattaaaa acaactctaa gaaaaagtgg ttttttttcc
aagactcaaa gaagatacaa 2460 gttgagcagc ctcaaagaag atttactcca
gcggtctgct tttaccagcc aggcaccact 2520 gtattaatca gtgatgaaga
ctcccctagc tccccaggtc agacaaccag cttctcaaga 2580 ccctttggtg
ttgcagctga tacagaacat tcagcaaata gtgaaggcag ccatgagact 2640
ggggattctg ggcggttttc tcatgagtcc aacgatgaga tacatctgtc ctcagttata
2700 agtaccacac cccccaacct ctga 2724 20 907 PRT homo sapiens 20 Met
Ser Glu Asn Lys Arg Ile Glu Val Leu Ser Asn Gly Ser Leu Tyr 1 5 10
15 Ile Ser Glu Val Glu Gly Arg Arg Gly Glu Gln Ser Asp Glu Gly Phe
20 25 30 Tyr Gln Cys Leu Ala Met Asn Lys Tyr Gly Ala Ile Leu Ser
Gln Lys 35 40 45 Ala His Leu Ala Leu Ser Thr Ile Ser Ala Phe Glu
Val Gln Pro Ile 50 55 60 Ser Thr Glu Val His Glu Gly Gly Val Ala
Arg Phe Ala Cys Lys Ile 65 70 75 80 Ser Ser His Pro Pro Ala Val Ile
Thr Trp Glu Phe Asn Arg Thr Thr 85 90 95 Leu Pro Met Thr Met Asp
Arg Ile Thr Ala Leu Pro Thr Gly Val Leu 100 105 110 Gln Ile Tyr Asp
Val Ser Gln Arg Asp Ser Gly Asn Tyr Arg Cys Ile 115 120 125 Ala Ala
Thr Val Ala His Arg Arg Lys Ser Met Glu Ala Ser Leu Thr 130 135 140
Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His Thr Pro Thr Ile Ile 145
150 155 160 Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu His Gln Thr Val
Val Leu 165 170 175 Glu Cys Met Ala Thr Gly Asn Pro Lys Pro Ile Ile
Ser Trp Ser Arg 180 185 190 Leu Asp His Lys Ser Ile Asp Val Phe Asn
Thr Arg Val Leu Gly Asn 195 200 205 Gly Asn Leu Met Ile Ser Asp Val
Arg Leu Gln His Ala Gly Val Tyr 210 215 220 Val Cys Arg Ala Thr Thr
Pro Gly Thr
Arg Asn Phe Thr Val Ala Met 225 230 235 240 Ala Thr Leu Thr Val Leu
Ala Pro Pro Ser Phe Val Glu Trp Pro Glu 245 250 255 Ser Leu Thr Arg
Pro Arg Ala Gly Thr Ala Arg Phe Val Cys Gln Ala 260 265 270 Glu Gly
Ile Pro Ser Pro Lys Met Ser Trp Leu Lys Asn Gly Arg Lys 275 280 285
Ile His Ser Asn Gly Arg Ile Lys Met Tyr Asn Ser Lys Leu Val Ile 290
295 300 Asn Gln Ile Ile Pro Glu Asp Asp Ala Ile Tyr Gln Cys Met Ala
Glu 305 310 315 320 Asn Ser Gln Gly Ser Ile Leu Ser Arg Ala Arg Leu
Thr Val Val Met 325 330 335 Ser Glu Asp Arg Pro Ser Ala Pro Tyr Asn
Val His Ala Glu Thr Met 340 345 350 Ser Ser Ser Ala Ile Leu Leu Ala
Trp Glu Arg Pro Leu Tyr Asn Ser 355 360 365 Asp Lys Val Ile Ala Tyr
Ser Val His Tyr Met Lys Ala Glu Gly Leu 370 375 380 Asn Asn Glu Glu
Tyr Gln Val Val Ile Gly Asn Asp Thr Thr His Tyr 385 390 395 400 Ile
Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr Thr Phe Tyr Ile Val 405 410
415 Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser Asp His Val Thr Gln
420 425 430 Asn Thr Leu Glu Asp Asp Pro Arg Arg Lys Tyr His Val Arg
Leu Leu 435 440 445 Ala Tyr Asn Asn Ile Asp Asp Gly Tyr Gln Ala Asp
Gln Thr Val Ser 450 455 460 Thr Pro Gly Cys Val Ser Val Arg Asp Arg
Met Val Pro Pro Pro Pro 465 470 475 480 Pro Pro His His Leu Tyr Ala
Lys Ala Asn Thr Ser Ser Ser Ile Phe 485 490 495 Leu His Trp Arg Arg
Pro Ala Phe Thr Ala Ala Gln Ile Ile Asn Tyr 500 505 510 Thr Ile Arg
Cys Asn Pro Val Gly Leu Gln Asn Ala Ser Leu Val Leu 515 520 525 Tyr
Leu Gln Thr Ser Glu Thr His Met Leu Val Gln Gly Leu Glu Pro 530 535
540 Asn Thr Lys Tyr Glu Phe Ala Val Arg Leu His Val Asp Gln Leu Ser
545 550 555 560 Ser Pro Trp Ser Pro Val Val Tyr His Ser Thr Leu Pro
Glu Ala Pro 565 570 575 Ala Gly Pro Pro Val Gly Val Lys Val Thr Leu
Ile Glu Asp Asp Thr 580 585 590 Ala Leu Val Ser Trp Lys Pro Pro Asp
Gly Pro Glu Thr Val Val Thr 595 600 605 Arg Tyr Thr Ile Leu Tyr Ala
Ser Arg Lys Ala Trp Ile Ala Gly Glu 610 615 620 Trp Gln Val Leu His
Arg Glu Gly Ala Ile Thr Met Ala Leu Leu Glu 625 630 635 640 Asn Leu
Val Ala Gly Asn Val Tyr Ile Val Lys Ile Ser Ala Ser Asn 645 650 655
Glu Val Gly Glu Gly Pro Phe Ser Asn Ser Val Glu Leu Ala Val Leu 660
665 670 Pro Lys Glu Thr Ser Glu Ser Asn Gln Arg Pro Lys Arg Leu Asp
Ser 675 680 685 Ala Asp Ala Lys Val Tyr Ser Gly Tyr Tyr His Leu Asp
Gln Lys Ser 690 695 700 Met Thr Gly Ile Ala Val Gly Val Gly Ile Ala
Leu Thr Cys Ile Leu 705 710 715 720 Ile Cys Val Leu Ile Leu Ile Tyr
Arg Ser Lys Ala Arg Lys Ser Ser 725 730 735 Ala Ser Lys Thr Ala Gln
Asn Gly Thr Gln Gln Leu Pro Arg Thr Ser 740 745 750 Ala Ser Leu Ala
Ser Gly Asn Glu Val Gly Lys Asn Leu Glu Gly Ala 755 760 765 Val Gly
Asn Glu Glu Ser Leu Met Pro Met Ile Met Pro Asn Ser Phe 770 775 780
Ile Asp Ala Lys Gly Gly Thr Asp Leu Ile Ile Asn Ser Tyr Gly Pro 785
790 795 800 Ile Ile Lys Asn Asn Ser Lys Lys Lys Trp Phe Phe Phe Gln
Asp Ser 805 810 815 Lys Lys Ile Gln Val Glu Gln Pro Gln Arg Arg Phe
Thr Pro Ala Val 820 825 830 Cys Phe Tyr Gln Pro Gly Thr Thr Val Leu
Ile Ser Asp Glu Asp Ser 835 840 845 Pro Ser Ser Pro Gly Gln Thr Thr
Ser Phe Ser Arg Pro Phe Gly Val 850 855 860 Ala Ala Asp Thr Glu His
Ser Ala Asn Ser Glu Gly Ser His Glu Thr 865 870 875 880 Gly Asp Ser
Gly Arg Phe Ser His Glu Ser Asn Asp Glu Ile His Leu 885 890 895 Ser
Ser Val Ile Ser Thr Thr Pro Pro Asn Leu 900 905 21 2139 DNA homo
sapiens 21 atgtcatggt tgaaaaatgg aaggaagata cattcgaatg gtagaattaa
aatgtacaac 60 agtaaattgg taattaacca gattattcct gaagatgatg
ctatttatca gtgcatggct 120 gagaatagcc aaggatctat tttatctaga
gccagactga ctgtagtgat gtcagaagac 180 agacccagtg ctccctataa
tgtacatgct gaaaccatgt caagctcagc cattctttta 240 gcctgggaga
ggccacttta taattcagac aaagtcattg cctattctgt acactacatg 300
aaagcagaag gtttaaataa tgaagagtat caagtagtca tcggaaatga cacaactcat
360 tatattattg atgacttaga gcctgccagc aattatactt tctacattgt
agcatatatg 420 ccaatgggag ccagccagat gtctgaccat gtgacacaga
atactctaga ggatgttccc 480 ctgagacctc ctgaaattag tttgacaagt
cgaagtccca ctgatattct catctcctgg 540 ctgccaatcc cagccaaata
tcggcggggc caagtggtgc tgtatcgctt gtctttccgc 600 ctaagtactg
agaattcaat ccaagttctg gagctcccgg ggaccacgca tgagtacctt 660
ttggaaggcc tgaaacctga cagtgtctac ctggttcgga ttactgctgc caccagagtg
720 gggctgggag agtcatcagt atggacttca cataggacgc ccaaagctac
aagcgtgaaa 780 gcccctaagt ctccagagtt gcatttggag cctctgaact
gtaccaccat ttctgtgagg 840 tggcagcaag atgtagagga cacagctgct
attcagggct acaagctgta ctacaaggaa 900 gaagggcagc aggagaatgg
gcccattttc ttggatacca aggacctact ctatactctc 960 agtggcttag
accccagaag aaaatatcat gtgagactcc tggcttacaa caacatagac 1020
gatggctatc aggcagatca gactgtcagc actccaggat gcgtgtctgt tcgtgatcgc
1080 atggtccctc ctccaccacc accccaccat ctctatgcga aggctaacac
ctcatcttcc 1140 atcttcctgc actggaggag gcctgcattc accgctgcac
aaatcattaa ctacaccatc 1200 cgctgtaatc ctgttggcct gcagaatgct
tctttggttc tgtaccttca aacatcagaa 1260 actcacatgt tggttcaagg
tctagaacca aacaccaaat acgaatttgc cgttcgatta 1320 catgtggatc
agctttccag tccttggagc cctgtagtct accattctac tcttccagaa 1380
gcaccagcag gcccaccagt tggagtaaaa gtgacattaa tagaggatga cactgccctg
1440 gtttcttgga aaccccctga tggcccagaa acagttgtga cccgctatac
tatcttatat 1500 gcatctagga aggcctggat tgcaggagag tggcaggtct
tacaccgtga aggggcaata 1560 accatggctt tgctagaaaa cttggtagca
ggaaatgtgt acattgtcaa gatatctgca 1620 tccaatgagg tgggagaagg
acccttttca aattctgtgg agctggcagt acttccaaag 1680 gaaacctctg
aatcaaatca gaggcccaag cgtttagatt ctgctgatgc caaagtttat 1740
tcaggatatt accatctgga ccaaaaatca atgactggca ttgctgtagg tgttggcata
1800 gccttgacct gcatcctcat ctgtgttctc atcttgatat accgaagtaa
agccaggaaa 1860 tcatctgctt ccaagacggc acagaatgga actcaacagt
tacctcgtac cagtgcctcc 1920 ttagctagtg gaaatgaggt aggaaagaac
ctggaaggag ctgtaggaaa tgaagaatct 1980 ttaatgccaa tgatcatgcc
aaacagcttc attgatgcaa aggtactgag ctgcgggatt 2040 tgctgcataa
gccgttcttc cattcctcct ccctgtgtgt gtaaaatgta cttcccccaa 2100
aattgtatgt tgaatgtatt ataccaatac tcttattaa 2139 22 712 PRT homo
sapiens 22 Met Ser Trp Leu Lys Asn Gly Arg Lys Ile His Ser Asn Gly
Arg Ile 1 5 10 15 Lys Met Tyr Asn Ser Lys Leu Val Ile Asn Gln Ile
Ile Pro Glu Asp 20 25 30 Asp Ala Ile Tyr Gln Cys Met Ala Glu Asn
Ser Gln Gly Ser Ile Leu 35 40 45 Ser Arg Ala Arg Leu Thr Val Val
Met Ser Glu Asp Arg Pro Ser Ala 50 55 60 Pro Tyr Asn Val His Ala
Glu Thr Met Ser Ser Ser Ala Ile Leu Leu 65 70 75 80 Ala Trp Glu Arg
Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr Ser 85 90 95 Val His
Tyr Met Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln Val 100 105 110
Val Ile Gly Asn Asp Thr Thr His Tyr Ile Ile Asp Asp Leu Glu Pro 115
120 125 Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly
Ala 130 135 140 Ser Gln Met Ser Asp His Val Thr Gln Asn Thr Leu Glu
Asp Val Pro 145 150 155 160 Leu Arg Pro Pro Glu Ile Ser Leu Thr Ser
Arg Ser Pro Thr Asp Ile 165 170 175 Leu Ile Ser Trp Leu Pro Ile Pro
Ala Lys Tyr Arg Arg Gly Gln Val 180 185 190 Val Leu Tyr Arg Leu Ser
Phe Arg Leu Ser Thr Glu Asn Ser Ile Gln 195 200 205 Val Leu Glu Leu
Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly Leu 210 215 220 Lys Pro
Asp Ser Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg Val 225 230 235
240 Gly Leu Gly Glu Ser Ser Val Trp Thr Ser His Arg Thr Pro Lys Ala
245 250 255 Thr Ser Val Lys Ala Pro Lys Ser Pro Glu Leu His Leu Glu
Pro Leu 260 265 270 Asn Cys Thr Thr Ile Ser Val Arg Trp Gln Gln Asp
Val Glu Asp Thr 275 280 285 Ala Ala Ile Gln Gly Tyr Lys Leu Tyr Tyr
Lys Glu Glu Gly Gln Gln 290 295 300 Glu Asn Gly Pro Ile Phe Leu Asp
Thr Lys Asp Leu Leu Tyr Thr Leu 305 310 315 320 Ser Gly Leu Asp Pro
Arg Arg Lys Tyr His Val Arg Leu Leu Ala Tyr 325 330 335 Asn Asn Ile
Asp Asp Gly Tyr Gln Ala Asp Gln Thr Val Ser Thr Pro 340 345 350 Gly
Cys Val Ser Val Arg Asp Arg Met Val Pro Pro Pro Pro Pro Pro 355 360
365 His His Leu Tyr Ala Lys Ala Asn Thr Ser Ser Ser Ile Phe Leu His
370 375 380 Trp Arg Arg Pro Ala Phe Thr Ala Ala Gln Ile Ile Asn Tyr
Thr Ile 385 390 395 400 Arg Cys Asn Pro Val Gly Leu Gln Asn Ala Ser
Leu Val Leu Tyr Leu 405 410 415 Gln Thr Ser Glu Thr His Met Leu Val
Gln Gly Leu Glu Pro Asn Thr 420 425 430 Lys Tyr Glu Phe Ala Val Arg
Leu His Val Asp Gln Leu Ser Ser Pro 435 440 445 Trp Ser Pro Val Val
Tyr His Ser Thr Leu Pro Glu Ala Pro Ala Gly 450 455 460 Pro Pro Val
Gly Val Lys Val Thr Leu Ile Glu Asp Asp Thr Ala Leu 465 470 475 480
Val Ser Trp Lys Pro Pro Asp Gly Pro Glu Thr Val Val Thr Arg Tyr 485
490 495 Thr Ile Leu Tyr Ala Ser Arg Lys Ala Trp Ile Ala Gly Glu Trp
Gln 500 505 510 Val Leu His Arg Glu Gly Ala Ile Thr Met Ala Leu Leu
Glu Asn Leu 515 520 525 Val Ala Gly Asn Val Tyr Ile Val Lys Ile Ser
Ala Ser Asn Glu Val 530 535 540 Gly Glu Gly Pro Phe Ser Asn Ser Val
Glu Leu Ala Val Leu Pro Lys 545 550 555 560 Glu Thr Ser Glu Ser Asn
Gln Arg Pro Lys Arg Leu Asp Ser Ala Asp 565 570 575 Ala Lys Val Tyr
Ser Gly Tyr Tyr His Leu Asp Gln Lys Ser Met Thr 580 585 590 Gly Ile
Ala Val Gly Val Gly Ile Ala Leu Thr Cys Ile Leu Ile Cys 595 600 605
Val Leu Ile Leu Ile Tyr Arg Ser Lys Ala Arg Lys Ser Ser Ala Ser 610
615 620 Lys Thr Ala Gln Asn Gly Thr Gln Gln Leu Pro Arg Thr Ser Ala
Ser 625 630 635 640 Leu Ala Ser Gly Asn Glu Val Gly Lys Asn Leu Glu
Gly Ala Val Gly 645 650 655 Asn Glu Glu Ser Leu Met Pro Met Ile Met
Pro Asn Ser Phe Ile Asp 660 665 670 Ala Lys Val Leu Ser Cys Gly Ile
Cys Cys Ile Ser Arg Ser Ser Ile 675 680 685 Pro Pro Pro Cys Val Cys
Lys Met Tyr Phe Pro Gln Asn Cys Met Leu 690 695 700 Asn Val Leu Tyr
Gln Tyr Ser Tyr 705 710 23 1875 DNA homo sapiens 23 atggaaggaa
gatacattcg aatggtagaa ttaaaatgta caacaggttt aaataatgaa 60
gagtatcaag tagtcatcgg aaatgacaca actcattata ttattgatga cttagagcct
120 gccagcaatt atactttcta cattgtagca tatatgccaa tgggagccag
ccagatgtct 180 gaccatgtga cacagaatac tctagaggat gttcccctga
gacctcctga aattagtttg 240 acaagtcgaa gtcccactga tattctcatc
tcctggctgc caatcccagc caaatatcgg 300 cggggccaag tggtgctgta
tcgcttgtct ttccgcctaa gtactgagaa ttcaatccaa 360 gttctggagc
tcccggggac cacgcatgag taccttttgg aaggcctgaa acctgacagt 420
gtctacctgg ttcggattac tgctgccacc agagtggggc tgggagagtc atcagtatgg
480 acttcacata ggacgcccaa agctacaagc gtgaaagccc ctaagtctcc
agagttgcat 540 ttggagcctc tgaactgtac caccatttct gtgaggtggc
agcaagatgt agaggacaca 600 gctgctattc agggctacaa gctgtactac
aaggaagaag ggcagcagga gaatgggccc 660 attttcttgg ataccaagga
cctactctat actctcagtg gcttagaccc cagaagaaaa 720 tatcatgtga
gactcctggc ttacaacaac atagacgatg gctatcaggc agatcagact 780
gtcagcactc caggatgcgt gtctgttcgt gatcgcatgg tccctcctcc accaccaccc
840 caccatctct atgcgaaggc taacacctca tcttccatct tcctgcactg
gaggaggcct 900 gcattcaccg ctgcacaaat cattaactac accatccgct
gtaatcctgt tggcctgcag 960 aatgcttctt tggttctgta ccttcaaaca
tcagaaactc acatgttggt tcaaggtcta 1020 gaaccaaaca ccaaatacga
atttgccgtt cgattacatg tggatcagct ttccagtcct 1080 tggagccctg
tagtctacca ttctactctt ccagaagcac cagcaggccc accagttgga 1140
gtaaaagtga cattaataga ggatgacact gccctggttt cttggaaacc ccctgatggc
1200 ccagaaacag ttgtgacccg ctatactatc ttatatgcat ctaggaaggc
ctggattgca 1260 ggagagtggc aggtcttaca ccgtgaaggg gcaataacca
tggctttgct agaaaacttg 1320 gtagcaggaa atgtgtacat tgtcaagata
tctgcatcca atgaggtggg agaaggaccc 1380 ttttcaaatt ctgtggagct
ggcagtactt ccaaaggaaa cctctgaatc aaatcagagg 1440 cccaagcgtt
tagattctgc tgatgccaaa gtttattcag gatattacca tctggaccaa 1500
aaatcaatga ctggcattgc tgtaggtgtt ggcatagcct tgacctgcat cctcatctgt
1560 gttctcatct tgatataccg aagtaaagcc aggaaatcat ctgcttccaa
gacggcacag 1620 aatggaactc aacagttacc tcgtaccagt gcctccttag
ctagtggaaa tgaggtagga 1680 aagaacctgg aaggagctgt aggaaatgaa
gaatctttaa tgccaatgat catgccaaac 1740 agcttcattg atgcaaaggt
actgagctgc gggatttgct gcataagccg ttcttccatt 1800 cctcctccct
gtgtgtgtaa aatgtacttc ccccaaaatt gtatgttgaa tgtattatac 1860
caatactctt attaa 1875 24 624 PRT homo sapiens 24 Met Glu Gly Arg
Tyr Ile Arg Met Val Glu Leu Lys Cys Thr Thr Gly 1 5 10 15 Leu Asn
Asn Glu Glu Tyr Gln Val Val Ile Gly Asn Asp Thr Thr His 20 25 30
Tyr Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr Thr Phe Tyr Ile 35
40 45 Val Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser Asp His Val
Thr 50 55 60 Gln Asn Thr Leu Glu Asp Val Pro Leu Arg Pro Pro Glu
Ile Ser Leu 65 70 75 80 Thr Ser Arg Ser Pro Thr Asp Ile Leu Ile Ser
Trp Leu Pro Ile Pro 85 90 95 Ala Lys Tyr Arg Arg Gly Gln Val Val
Leu Tyr Arg Leu Ser Phe Arg 100 105 110 Leu Ser Thr Glu Asn Ser Ile
Gln Val Leu Glu Leu Pro Gly Thr Thr 115 120 125 His Glu Tyr Leu Leu
Glu Gly Leu Lys Pro Asp Ser Val Tyr Leu Val 130 135 140 Arg Ile Thr
Ala Ala Thr Arg Val Gly Leu Gly Glu Ser Ser Val Trp 145 150 155 160
Thr Ser His Arg Thr Pro Lys Ala Thr Ser Val Lys Ala Pro Lys Ser 165
170 175 Pro Glu Leu His Leu Glu Pro Leu Asn Cys Thr Thr Ile Ser Val
Arg 180 185 190 Trp Gln Gln Asp Val Glu Asp Thr Ala Ala Ile Gln Gly
Tyr Lys Leu 195 200 205 Tyr Tyr Lys Glu Glu Gly Gln Gln Glu Asn Gly
Pro Ile Phe Leu Asp 210 215 220 Thr Lys Asp Leu Leu Tyr Thr Leu Ser
Gly Leu Asp Pro Arg Arg Lys 225 230 235 240 Tyr His Val Arg Leu Leu
Ala Tyr Asn Asn Ile Asp Asp Gly Tyr Gln 245 250 255 Ala Asp Gln Thr
Val Ser Thr Pro Gly Cys Val Ser Val Arg Asp Arg 260 265 270 Met Val
Pro Pro Pro Pro Pro Pro His His Leu Tyr Ala Lys Ala Asn 275 280 285
Thr Ser Ser Ser Ile Phe Leu His Trp Arg Arg Pro Ala Phe Thr Ala 290
295 300 Ala Gln Ile Ile Asn Tyr Thr Ile Arg Cys Asn Pro Val Gly Leu
Gln 305 310 315 320 Asn Ala Ser Leu Val Leu Tyr Leu Gln Thr Ser Glu
Thr His Met Leu 325 330 335 Val Gln Gly Leu Glu Pro Asn Thr Lys Tyr
Glu Phe Ala Val Arg Leu 340 345 350 His Val Asp Gln Leu Ser Ser Pro
Trp Ser Pro Val Val Tyr His Ser 355 360 365 Thr Leu Pro Glu Ala Pro
Ala Gly Pro Pro Val Gly Val Lys Val Thr 370
375 380 Leu Ile Glu Asp Asp Thr Ala Leu Val Ser Trp Lys Pro Pro Asp
Gly 385 390 395 400 Pro Glu Thr Val Val Thr Arg Tyr Thr Ile Leu Tyr
Ala Ser Arg Lys 405 410 415 Ala Trp Ile Ala Gly Glu Trp Gln Val Leu
His Arg Glu Gly Ala Ile 420 425 430 Thr Met Ala Leu Leu Glu Asn Leu
Val Ala Gly Asn Val Tyr Ile Val 435 440 445 Lys Ile Ser Ala Ser Asn
Glu Val Gly Glu Gly Pro Phe Ser Asn Ser 450 455 460 Val Glu Leu Ala
Val Leu Pro Lys Glu Thr Ser Glu Ser Asn Gln Arg 465 470 475 480 Pro
Lys Arg Leu Asp Ser Ala Asp Ala Lys Val Tyr Ser Gly Tyr Tyr 485 490
495 His Leu Asp Gln Lys Ser Met Thr Gly Ile Ala Val Gly Val Gly Ile
500 505 510 Ala Leu Thr Cys Ile Leu Ile Cys Val Leu Ile Leu Ile Tyr
Arg Ser 515 520 525 Lys Ala Arg Lys Ser Ser Ala Ser Lys Thr Ala Gln
Asn Gly Thr Gln 530 535 540 Gln Leu Pro Arg Thr Ser Ala Ser Leu Ala
Ser Gly Asn Glu Val Gly 545 550 555 560 Lys Asn Leu Glu Gly Ala Val
Gly Asn Glu Glu Ser Leu Met Pro Met 565 570 575 Ile Met Pro Asn Ser
Phe Ile Asp Ala Lys Val Leu Ser Cys Gly Ile 580 585 590 Cys Cys Ile
Ser Arg Ser Ser Ile Pro Pro Pro Cys Val Cys Lys Met 595 600 605 Tyr
Phe Pro Gln Asn Cys Met Leu Asn Val Leu Tyr Gln Tyr Ser Tyr 610 615
620 25 1644 DNA homo sapiens 25 atgtcatggt tgaaaaatgg aaggaagata
cattcgaatg gtagaattaa aatgtacaac 60 agtaaattgg taattaacca
gattattcct gaagatgatg ctatttatca gtgcatggct 120 gagaatagcc
aaggatctat tttatctaga gccagactga ctgtagtgat gtcagaagac 180
agacccagtg ctccctataa tgtacatgct gaaaccatgt caagctcagc cattctttta
240 gcctgggaga ggccacttta taattcagac aaagtcattg cctattctgt
acactacatg 300 aaagcagaag gtttaaataa tgaagagtat caagtagtca
tcggaaatga cacaactcat 360 tatattattg atgacttaga gcctgccagc
aattatactt tctacattgt agcatatatg 420 ccaatgggag ccagccagat
gtctgaccat gtgacacaga atactctaga ggatgacccc 480 agaagaaaat
atcatgtgag actcctggct tacaacaaca tagacgatgg ctatcaggca 540
gatcagactg tcagcactcc aggatgcgtg tctgttcgtg atcgcatggt ccctcctcca
600 ccaccacccc accatctcta tgcgaaggct aacacctcat cttccatctt
cctgcactgg 660 aggaggcctg cattcaccgc tgcacaaatc attaactaca
ccatccgctg taatcctgtt 720 ggcctgcaga atgcttcttt ggttctgtac
cttcaaacat cagaaactca catgttggtt 780 caaggtctag aaccaaacac
caaatacgaa tttgccgttc gattacatgt ggatcagctt 840 tccagtcctt
ggagccctgt agtctaccat tctactcttc cagaagcacc agcaggccca 900
ccagttggag taaaagtgac attaatagag gatgacactg ccctggtttc ttggaaaccc
960 cctgatggcc cagaaacagt tgtgacccgc tatactatct tatatgcatc
taggaaggcc 1020 tggattgcag gagagtggca ggtcttacac cgtgaagggg
caataaccat ggctttgcta 1080 gaaaacttgg tagcaggaaa tgtgtacatt
gtcaagatat ctgcatccaa tgaggtggga 1140 gaaggaccct tttcaaattc
tgtggagctg gcagtacttc caaaggaaac ctctgaatca 1200 aatcagaggc
ccaagcgttt agattctgct gatgccaaag tttattcagg atattaccat 1260
ctggaccaaa aatcaatgac tggcattgct gtaggtgttg gcatagcctt gacctgcatc
1320 ctcatctgtg ttctcatctt gatataccga agtaaagcca ggaaatcatc
tgcttccaag 1380 acggcacaga atggaactca acagttacct cgtaccagtg
cctccttagc tagtggaaat 1440 gaggtaggaa agaacctgga aggagctgta
ggaaatgaag aatctttaat gccaatgatc 1500 atgccaaaca gcttcattga
tgcaaaggta ctgagctgcg ggatttgctg cataagccgt 1560 tcttccattc
ctcctccctg tgtgtgtaaa atgtacttcc cccaaaattg tatgttgaat 1620
gtattatacc aatactctta ttaa 1644 26 547 PRT homo sapiens 26 Met Ser
Trp Leu Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg Ile 1 5 10 15
Lys Met Tyr Asn Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu Asp 20
25 30 Asp Ala Ile Tyr Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile
Leu 35 40 45 Ser Arg Ala Arg Leu Thr Val Val Met Ser Glu Asp Arg
Pro Ser Ala 50 55 60 Pro Tyr Asn Val His Ala Glu Thr Met Ser Ser
Ser Ala Ile Leu Leu 65 70 75 80 Ala Trp Glu Arg Pro Leu Tyr Asn Ser
Asp Lys Val Ile Ala Tyr Ser 85 90 95 Val His Tyr Met Lys Ala Glu
Gly Leu Asn Asn Glu Glu Tyr Gln Val 100 105 110 Val Ile Gly Asn Asp
Thr Thr His Tyr Ile Ile Asp Asp Leu Glu Pro 115 120 125 Ala Ser Asn
Tyr Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly Ala 130 135 140 Ser
Gln Met Ser Asp His Val Thr Gln Asn Thr Leu Glu Asp Asp Pro 145 150
155 160 Arg Arg Lys Tyr His Val Arg Leu Leu Ala Tyr Asn Asn Ile Asp
Asp 165 170 175 Gly Tyr Gln Ala Asp Gln Thr Val Ser Thr Pro Gly Cys
Val Ser Val 180 185 190 Arg Asp Arg Met Val Pro Pro Pro Pro Pro Pro
His His Leu Tyr Ala 195 200 205 Lys Ala Asn Thr Ser Ser Ser Ile Phe
Leu His Trp Arg Arg Pro Ala 210 215 220 Phe Thr Ala Ala Gln Ile Ile
Asn Tyr Thr Ile Arg Cys Asn Pro Val 225 230 235 240 Gly Leu Gln Asn
Ala Ser Leu Val Leu Tyr Leu Gln Thr Ser Glu Thr 245 250 255 His Met
Leu Val Gln Gly Leu Glu Pro Asn Thr Lys Tyr Glu Phe Ala 260 265 270
Val Arg Leu His Val Asp Gln Leu Ser Ser Pro Trp Ser Pro Val Val 275
280 285 Tyr His Ser Thr Leu Pro Glu Ala Pro Ala Gly Pro Pro Val Gly
Val 290 295 300 Lys Val Thr Leu Ile Glu Asp Asp Thr Ala Leu Val Ser
Trp Lys Pro 305 310 315 320 Pro Asp Gly Pro Glu Thr Val Val Thr Arg
Tyr Thr Ile Leu Tyr Ala 325 330 335 Ser Arg Lys Ala Trp Ile Ala Gly
Glu Trp Gln Val Leu His Arg Glu 340 345 350 Gly Ala Ile Thr Met Ala
Leu Leu Glu Asn Leu Val Ala Gly Asn Val 355 360 365 Tyr Ile Val Lys
Ile Ser Ala Ser Asn Glu Val Gly Glu Gly Pro Phe 370 375 380 Ser Asn
Ser Val Glu Leu Ala Val Leu Pro Lys Glu Thr Ser Glu Ser 385 390 395
400 Asn Gln Arg Pro Lys Arg Leu Asp Ser Ala Asp Ala Lys Val Tyr Ser
405 410 415 Gly Tyr Tyr His Leu Asp Gln Lys Ser Met Thr Gly Ile Ala
Val Gly 420 425 430 Val Gly Ile Ala Leu Thr Cys Ile Leu Ile Cys Val
Leu Ile Leu Ile 435 440 445 Tyr Arg Ser Lys Ala Arg Lys Ser Ser Ala
Ser Lys Thr Ala Gln Asn 450 455 460 Gly Thr Gln Gln Leu Pro Arg Thr
Ser Ala Ser Leu Ala Ser Gly Asn 465 470 475 480 Glu Val Gly Lys Asn
Leu Glu Gly Ala Val Gly Asn Glu Glu Ser Leu 485 490 495 Met Pro Met
Ile Met Pro Asn Ser Phe Ile Asp Ala Lys Val Leu Ser 500 505 510 Cys
Gly Ile Cys Cys Ile Ser Arg Ser Ser Ile Pro Pro Pro Cys Val 515 520
525 Cys Lys Met Tyr Phe Pro Gln Asn Cys Met Leu Asn Val Leu Tyr Gln
530 535 540 Tyr Ser Tyr 545 27 2382 DNA homo sapiens 27 atgtcatggt
tgaaaaatgg aaggaagata cattcgaatg gtagaattaa aatgtacaac 60
agtaaattgg taattaacca gattattcct gaagatgatg ctatttatca gtgcatggct
120 gagaatagcc aaggatctat tttatctaga gccagactga ctgtagtgat
gtcagaagac 180 agacccagtg ctccctataa tgtacatgct gaaaccatgt
caagctcagc cattctttta 240 gcctgggaga ggccacttta taattcagac
aaagtcattg cctattctgt acactacatg 300 aaagcagaag gtttaaataa
tgaagagtat caagtagtca tcggaaatga cacaactcat 360 tatattattg
atgacttaga gcctgccagc aattatactt tctacattgt agcatatatg 420
ccaatgggag ccagccagat gtctgaccat gtgacacaga atactctaga ggatgttccc
480 ctgagacctc ctgaaattag tttgacaagt cgaagtccca ctgatattct
catctcctgg 540 ctgccaatcc cagccaaata tcggcggggc caagtggtgc
tgtatcgctt gtctttccgc 600 ctaagtactg agaattcaat ccaagttctg
gagctcccgg ggaccacgca tgagtacctt 660 ttggaaggcc tgaaacctga
cagtgtctac ctggttcgga ttactgctgc caccagagtg 720 gggctgggag
agtcatcagt atggacttca cataggacgc ccaaagctac aagcgtgaaa 780
gcccctaagt ctccagagtt gcatttggag cctctgaact gtaccaccat ttctgtgagg
840 tggcagcaag atgtagagga cacagctgct attcagggct acaagctgta
ctacaaggaa 900 gaagggcagc aggagaatgg gcccattttc ttggatacca
aggacctact ctatactctc 960 agtggcttag accccagaag aaaatatcat
gtgagactcc tggcttacaa caacatagac 1020 gatggctatc aggcagatca
gactgtcagc actccaggat gcgtgtctgt tcgtgatcgc 1080 atggtccctc
ctccaccacc accccaccat ctctatgcga aggctaacac ctcatcttcc 1140
atcttcctgc actggaggag gcctgcattc accgctgcac aaatcattaa ctacaccatc
1200 cgctgtaatc ctgttggcct gcagaatgct tctttggttc tgtaccttca
aacatcagaa 1260 actcacatgt tggttcaagg tctagaacca aacaccaaat
acgaatttgc cgttcgatta 1320 catgtggatc agctttccag tccttggagc
cctgtagtct accattctac tcttccagaa 1380 gcaccagcag gcccaccagt
tggagtaaaa gtgacattaa tagaggatga cactgccctg 1440 gtttcttgga
aaccccctga tggcccagaa acagttgtga cccgctatac tatcttatat 1500
gcatctagga aggcctggat tgcaggagag tggcaggtct tacaccgtga aggggcaata
1560 accatggctt tgctagaaaa cttggtagca ggaaatgtgt acattgtcaa
gatatctgca 1620 tccaatgagg tgggagaagg acccttttca aattctgtgg
agctggcagt acttccaaag 1680 gaaacctctg aatcaaatca gaggcccaag
cgtttagatt ctgctgatgc caaagtttat 1740 tcaggatatt accatctgga
ccaaaaatca atgactggca ttgctgtagg tgttggcata 1800 gccttgacct
gcatcctcat ctgtgttctc atcttgatat accgaagtaa agccaggaaa 1860
tcatctgctt ccaagacggc acagaatgga actcaacagt tacctcgtac cagtgcctcc
1920 ttagctagtg gaaatgaggt aggaaagaac ctggaaggag ctgtaggaaa
tgaagaatct 1980 ttaatgccaa tgatcatgcc aaacagcttc attgatgcaa
agggaggaac tgacctgata 2040 attaatagct atggtcctat aattaaaaac
aactctaaga aaaagtggtt ttttttccaa 2100 gactcaaaga agatacaagt
tgagcagcct caaagaagat ttactccagc ggtctgcttt 2160 taccagccag
gcaccactgt attaatcagt gatgaagact cccctagctc cccaggtcag 2220
acaaccagct tctcaagacc ctttggtgtt gcagctgata cagaacattc agcaaatagt
2280 gaaggcagcc atgagactgg ggattctggg cggttttctc atgagtccaa
cgatgagata 2340 catctgtcct cagttataag taccacaccc cccaacctct ga 2382
28 793 PRT homo sapiens 28 Met Ser Trp Leu Lys Asn Gly Arg Lys Ile
His Ser Asn Gly Arg Ile 1 5 10 15 Lys Met Tyr Asn Ser Lys Leu Val
Ile Asn Gln Ile Ile Pro Glu Asp 20 25 30 Asp Ala Ile Tyr Gln Cys
Met Ala Glu Asn Ser Gln Gly Ser Ile Leu 35 40 45 Ser Arg Ala Arg
Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser Ala 50 55 60 Pro Tyr
Asn Val His Ala Glu Thr Met Ser Ser Ser Ala Ile Leu Leu 65 70 75 80
Ala Trp Glu Arg Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr Ser 85
90 95 Val His Tyr Met Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln
Val 100 105 110 Val Ile Gly Asn Asp Thr Thr His Tyr Ile Ile Asp Asp
Leu Glu Pro 115 120 125 Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr
Met Pro Met Gly Ala 130 135 140 Ser Gln Met Ser Asp His Val Thr Gln
Asn Thr Leu Glu Asp Val Pro 145 150 155 160 Leu Arg Pro Pro Glu Ile
Ser Leu Thr Ser Arg Ser Pro Thr Asp Ile 165 170 175 Leu Ile Ser Trp
Leu Pro Ile Pro Ala Lys Tyr Arg Arg Gly Gln Val 180 185 190 Val Leu
Tyr Arg Leu Ser Phe Arg Leu Ser Thr Glu Asn Ser Ile Gln 195 200 205
Val Leu Glu Leu Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly Leu 210
215 220 Lys Pro Asp Ser Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg
Val 225 230 235 240 Gly Leu Gly Glu Ser Ser Val Trp Thr Ser His Arg
Thr Pro Lys Ala 245 250 255 Thr Ser Val Lys Ala Pro Lys Ser Pro Glu
Leu His Leu Glu Pro Leu 260 265 270 Asn Cys Thr Thr Ile Ser Val Arg
Trp Gln Gln Asp Val Glu Asp Thr 275 280 285 Ala Ala Ile Gln Gly Tyr
Lys Leu Tyr Tyr Lys Glu Glu Gly Gln Gln 290 295 300 Glu Asn Gly Pro
Ile Phe Leu Asp Thr Lys Asp Leu Leu Tyr Thr Leu 305 310 315 320 Ser
Gly Leu Asp Pro Arg Arg Lys Tyr His Val Arg Leu Leu Ala Tyr 325 330
335 Asn Asn Ile Asp Asp Gly Tyr Gln Ala Asp Gln Thr Val Ser Thr Pro
340 345 350 Gly Cys Val Ser Val Arg Asp Arg Met Val Pro Pro Pro Pro
Pro Pro 355 360 365 His His Leu Tyr Ala Lys Ala Asn Thr Ser Ser Ser
Ile Phe Leu His 370 375 380 Trp Arg Arg Pro Ala Phe Thr Ala Ala Gln
Ile Ile Asn Tyr Thr Ile 385 390 395 400 Arg Cys Asn Pro Val Gly Leu
Gln Asn Ala Ser Leu Val Leu Tyr Leu 405 410 415 Gln Thr Ser Glu Thr
His Met Leu Val Gln Gly Leu Glu Pro Asn Thr 420 425 430 Lys Tyr Glu
Phe Ala Val Arg Leu His Val Asp Gln Leu Ser Ser Pro 435 440 445 Trp
Ser Pro Val Val Tyr His Ser Thr Leu Pro Glu Ala Pro Ala Gly 450 455
460 Pro Pro Val Gly Val Lys Val Thr Leu Ile Glu Asp Asp Thr Ala Leu
465 470 475 480 Val Ser Trp Lys Pro Pro Asp Gly Pro Glu Thr Val Val
Thr Arg Tyr 485 490 495 Thr Ile Leu Tyr Ala Ser Arg Lys Ala Trp Ile
Ala Gly Glu Trp Gln 500 505 510 Val Leu His Arg Glu Gly Ala Ile Thr
Met Ala Leu Leu Glu Asn Leu 515 520 525 Val Ala Gly Asn Val Tyr Ile
Val Lys Ile Ser Ala Ser Asn Glu Val 530 535 540 Gly Glu Gly Pro Phe
Ser Asn Ser Val Glu Leu Ala Val Leu Pro Lys 545 550 555 560 Glu Thr
Ser Glu Ser Asn Gln Arg Pro Lys Arg Leu Asp Ser Ala Asp 565 570 575
Ala Lys Val Tyr Ser Gly Tyr Tyr His Leu Asp Gln Lys Ser Met Thr 580
585 590 Gly Ile Ala Val Gly Val Gly Ile Ala Leu Thr Cys Ile Leu Ile
Cys 595 600 605 Val Leu Ile Leu Ile Tyr Arg Ser Lys Ala Arg Lys Ser
Ser Ala Ser 610 615 620 Lys Thr Ala Gln Asn Gly Thr Gln Gln Leu Pro
Arg Thr Ser Ala Ser 625 630 635 640 Leu Ala Ser Gly Asn Glu Val Gly
Lys Asn Leu Glu Gly Ala Val Gly 645 650 655 Asn Glu Glu Ser Leu Met
Pro Met Ile Met Pro Asn Ser Phe Ile Asp 660 665 670 Ala Lys Gly Gly
Thr Asp Leu Ile Ile Asn Ser Tyr Gly Pro Ile Ile 675 680 685 Lys Asn
Asn Ser Lys Lys Lys Trp Phe Phe Phe Gln Asp Ser Lys Lys 690 695 700
Ile Gln Val Glu Gln Pro Gln Arg Arg Phe Thr Pro Ala Val Cys Phe 705
710 715 720 Tyr Gln Pro Gly Thr Thr Val Leu Ile Ser Asp Glu Asp Ser
Pro Ser 725 730 735 Ser Pro Gly Gln Thr Thr Ser Phe Ser Arg Pro Phe
Gly Val Ala Ala 740 745 750 Asp Thr Glu His Ser Ala Asn Ser Glu Gly
Ser His Glu Thr Gly Asp 755 760 765 Ser Gly Arg Phe Ser His Glu Ser
Asn Asp Glu Ile His Leu Ser Ser 770 775 780 Val Ile Ser Thr Thr Pro
Pro Asn Leu 785 790 29 1887 DNA homo sapiens 29 atgtcatggt
tgaaaaatgg aaggaagata cattcgaatg gtagaattaa aatgtacaac 60
agtaaattgg taattaacca gattattcct gaagatgatg ctatttatca gtgcatggct
120 gagaatagcc aaggatctat tttatctaga gccagactga ctgtagtgat
gtcagaagac 180 agacccagtg ctccctataa tgtacatgct gaaaccatgt
caagctcagc cattctttta 240 gcctgggaga ggccacttta taattcagac
aaagtcattg cctattctgt acactacatg 300 aaagcagaag gtttaaataa
tgaagagtat caagtagtca tcggaaatga cacaactcat 360 tatattattg
atgacttaga gcctgccagc aattatactt tctacattgt agcatatatg 420
ccaatgggag ccagccagat gtctgaccat gtgacacaga atactctaga ggatgacccc
480 agaagaaaat atcatgtgag actcctggct tacaacaaca tagacgatgg
ctatcaggca 540 gatcagactg tcagcactcc aggatgcgtg tctgttcgtg
atcgcatggt ccctcctcca 600 ccaccacccc accatctcta tgcgaaggct
aacacctcat cttccatctt cctgcactgg 660 aggaggcctg cattcaccgc
tgcacaaatc attaactaca ccatccgctg taatcctgtt 720 ggcctgcaga
atgcttcttt ggttctgtac cttcaaacat cagaaactca catgttggtt 780
caaggtctag aaccaaacac caaatacgaa tttgccgttc gattacatgt ggatcagctt
840 tccagtcctt ggagccctgt agtctaccat tctactcttc cagaagcacc
agcaggccca 900 ccagttggag taaaagtgac attaatagag gatgacactg
ccctggtttc ttggaaaccc 960 cctgatggcc cagaaacagt tgtgacccgc
tatactatct tatatgcatc taggaaggcc 1020 tggattgcag gagagtggca
ggtcttacac cgtgaagggg caataaccat ggctttgcta 1080 gaaaacttgg
tagcaggaaa tgtgtacatt gtcaagatat ctgcatccaa tgaggtggga 1140
gaaggaccct
tttcaaattc tgtggagctg gcagtacttc caaaggaaac ctctgaatca 1200
aatcagaggc ccaagcgttt agattctgct gatgccaaag tttattcagg atattaccat
1260 ctggaccaaa aatcaatgac tggcattgct gtaggtgttg gcatagcctt
gacctgcatc 1320 ctcatctgtg ttctcatctt gatataccga agtaaagcca
ggaaatcatc tgcttccaag 1380 acggcacaga atggaactca acagttacct
cgtaccagtg cctccttagc tagtggaaat 1440 gaggtaggaa agaacctgga
aggagctgta ggaaatgaag aatctttaat gccaatgatc 1500 atgccaaaca
gcttcattga tgcaaaggga ggaactgacc tgataattaa tagctatggt 1560
cctataatta aaaacaactc taagaaaaag tggttttttt tccaagactc aaagaagata
1620 caagttgagc agcctcaaag aagatttact ccagcggtct gcttttacca
gccaggcacc 1680 actgtattaa tcagtgatga agactcccct agctccccag
gtcagacaac cagcttctca 1740 agaccctttg gtgttgcagc tgatacagaa
cattcagcaa atagtgaagg cagccatgag 1800 actggggatt ctgggcggtt
ttctcatgag tccaacgatg agatacatct gtcctcagtt 1860 ataagtacca
caccccccaa cctctga 1887 30 628 PRT homo sapiens 30 Met Ser Trp Leu
Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg Ile 1 5 10 15 Lys Met
Tyr Asn Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu Asp 20 25 30
Asp Ala Ile Tyr Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile Leu 35
40 45 Ser Arg Ala Arg Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser
Ala 50 55 60 Pro Tyr Asn Val His Ala Glu Thr Met Ser Ser Ser Ala
Ile Leu Leu 65 70 75 80 Ala Trp Glu Arg Pro Leu Tyr Asn Ser Asp Lys
Val Ile Ala Tyr Ser 85 90 95 Val His Tyr Met Lys Ala Glu Gly Leu
Asn Asn Glu Glu Tyr Gln Val 100 105 110 Val Ile Gly Asn Asp Thr Thr
His Tyr Ile Ile Asp Asp Leu Glu Pro 115 120 125 Ala Ser Asn Tyr Thr
Phe Tyr Ile Val Ala Tyr Met Pro Met Gly Ala 130 135 140 Ser Gln Met
Ser Asp His Val Thr Gln Asn Thr Leu Glu Asp Asp Pro 145 150 155 160
Arg Arg Lys Tyr His Val Arg Leu Leu Ala Tyr Asn Asn Ile Asp Asp 165
170 175 Gly Tyr Gln Ala Asp Gln Thr Val Ser Thr Pro Gly Cys Val Ser
Val 180 185 190 Arg Asp Arg Met Val Pro Pro Pro Pro Pro Pro His His
Leu Tyr Ala 195 200 205 Lys Ala Asn Thr Ser Ser Ser Ile Phe Leu His
Trp Arg Arg Pro Ala 210 215 220 Phe Thr Ala Ala Gln Ile Ile Asn Tyr
Thr Ile Arg Cys Asn Pro Val 225 230 235 240 Gly Leu Gln Asn Ala Ser
Leu Val Leu Tyr Leu Gln Thr Ser Glu Thr 245 250 255 His Met Leu Val
Gln Gly Leu Glu Pro Asn Thr Lys Tyr Glu Phe Ala 260 265 270 Val Arg
Leu His Val Asp Gln Leu Ser Ser Pro Trp Ser Pro Val Val 275 280 285
Tyr His Ser Thr Leu Pro Glu Ala Pro Ala Gly Pro Pro Val Gly Val 290
295 300 Lys Val Thr Leu Ile Glu Asp Asp Thr Ala Leu Val Ser Trp Lys
Pro 305 310 315 320 Pro Asp Gly Pro Glu Thr Val Val Thr Arg Tyr Thr
Ile Leu Tyr Ala 325 330 335 Ser Arg Lys Ala Trp Ile Ala Gly Glu Trp
Gln Val Leu His Arg Glu 340 345 350 Gly Ala Ile Thr Met Ala Leu Leu
Glu Asn Leu Val Ala Gly Asn Val 355 360 365 Tyr Ile Val Lys Ile Ser
Ala Ser Asn Glu Val Gly Glu Gly Pro Phe 370 375 380 Ser Asn Ser Val
Glu Leu Ala Val Leu Pro Lys Glu Thr Ser Glu Ser 385 390 395 400 Asn
Gln Arg Pro Lys Arg Leu Asp Ser Ala Asp Ala Lys Val Tyr Ser 405 410
415 Gly Tyr Tyr His Leu Asp Gln Lys Ser Met Thr Gly Ile Ala Val Gly
420 425 430 Val Gly Ile Ala Leu Thr Cys Ile Leu Ile Cys Val Leu Ile
Leu Ile 435 440 445 Tyr Arg Ser Lys Ala Arg Lys Ser Ser Ala Ser Lys
Thr Ala Gln Asn 450 455 460 Gly Thr Gln Gln Leu Pro Arg Thr Ser Ala
Ser Leu Ala Ser Gly Asn 465 470 475 480 Glu Val Gly Lys Asn Leu Glu
Gly Ala Val Gly Asn Glu Glu Ser Leu 485 490 495 Met Pro Met Ile Met
Pro Asn Ser Phe Ile Asp Ala Lys Gly Gly Thr 500 505 510 Asp Leu Ile
Ile Asn Ser Tyr Gly Pro Ile Ile Lys Asn Asn Ser Lys 515 520 525 Lys
Lys Trp Phe Phe Phe Gln Asp Ser Lys Lys Ile Gln Val Glu Gln 530 535
540 Pro Gln Arg Arg Phe Thr Pro Ala Val Cys Phe Tyr Gln Pro Gly Thr
545 550 555 560 Thr Val Leu Ile Ser Asp Glu Asp Ser Pro Ser Ser Pro
Gly Gln Thr 565 570 575 Thr Ser Phe Ser Arg Pro Phe Gly Val Ala Ala
Asp Thr Glu His Ser 580 585 590 Ala Asn Ser Glu Gly Ser His Glu Thr
Gly Asp Ser Gly Arg Phe Ser 595 600 605 His Glu Ser Asn Asp Glu Ile
His Leu Ser Ser Val Ile Ser Thr Thr 610 615 620 Pro Pro Asn Leu 625
31 3874 DNA homo sapiens 31 tgcttctcgc gagcggccgt ccgagcacca
gcctcgccgc cgcagagacg ctcgccacgc 60 cggtgccgga gccggagcgg
ggagccaggc tgcgtgcgac cagccgcaga gcagagagcg 120 cccggggcgg
gggccgcaga cggacagggg ctctgggcgg ccggggagca tgcccgcgcg 180
gctacgctga atggcgcctc ctctgcgacc cctcgcccgg ctgcgaccgc cggggatgct
240 gctccgcgcg ctcctgctcc tgctgmtgct cagtcctttg ccaggagtgt
ggtgctttag 300 cgaactgtct tttgtaaaag aaccacagga tgtaactgtc
acaagaaagg acccagtcgt 360 tttagattgc caggctcacg gagaagttcc
tattaaggtc acatggttga aaaatggagc 420 aaaaatgtct gaaaataaac
ggatcgaggt tctttctaac ggctctttat acatcagtga 480 ggtggaaggc
aggcgaggag agcagtccga tgaaggattt tatcagtgct tggcaatgaa 540
caaatatgga gccattctta gtcaaaaagc tcatcttgcc ttatcaacta tttctgcatt
600 tgaagtccag ccaatttcca ctgaggtcca cgaaggtgga gttgctcgat
ttgcatgcaa 660 gatttcatcc caccctcctg cagtcataac atgggagttc
aatcggacaa ctctacctat 720 gactatggac aggataactg ccctaccaac
aggagtattg cagatctatg atgtcagcca 780 aagggattct ggaaattatc
gttgtattgc tgccactgta gcccaccgac gtaaaagtat 840 ggaggcctcg
ctaactgtga ttccagctaa ggagtcaaaa tccttccaca caccarcaat 900
tatagcaggt ccacagaaca taacaacatc tcttcatcag actgtagttt tggaatgcat
960 ggccacagga aatcccaaac caatcatttc ttggagccgc cttgatcaca
aatccattga 1020 tgtctttaat actcgggtac ttggaaatgg taatctcatg
atatctgatg tcaggctaca 1080 acatgctgga gtatatgttt gtcgggccac
tacccctggc acacgcaact ttacagttgc 1140 tatggcaact ttaactgtat
tagctcctcc ttcatttgtt gaatggccag aaagtttaac 1200 aaggcctcga
gctggcactg ctcgatttgt gtgtcaggca gaaggaatcc cctctcccaa 1260
gatgtcatgg ttgaaaaatg gaaggaagat acattcgaat ggtagaatta aaatgtacaa
1320 cagtaaattg gtaattaacc agattattcc tgaagatgat gctatttatc
agtgcatggc 1380 tgagaatagc caaggatcta ttttatctag agccagactg
actgtagtga tgtcagaaga 1440 cagacccagt gctccctata atgtacatgc
tgaaaccatg tcaagctcag ccattctttt 1500 agcctgggag aggccacttt
ataattcaga caaagtcatt gcctattctg tacactacat 1560 gaaagcagaa
ggtttaaata atgaagagta tcaagtagtc atcggaaatg acacaactca 1620
ttatattatt gatgacttag agcctgccag caattatact ttctacattg tagcatatat
1680 gccaatggga gccagccaga tgtctgacca tgtgacacag aatactctag
aggatgttcc 1740 cctgagacct cctgaaatta gtttgacaag tcgaagtccc
actgatattc tcatctcctg 1800 gctgccaatc ccagccaaat atcggcgggg
ccaagtggtg ctgtatcgct tgtctttccg 1860 cctaagtact gagaattcaa
tccaagttct ggagctcccg gggaccacgc atgagtacct 1920 tttggaaggc
ctgaaacctg acagtgtcta cctggttcgg attactgctg ccaccagagt 1980
ggggctggga gagtcatcag tatggacttc acataggacg cccaaagcta caagcgtgaa
2040 agcccctaag tctccagagt tgcatttgga gcctctgaac tgtaccacca
tttctgtgag 2100 gtggcagcaa gatgtagagg acacagctgc tattcagggc
tacaagctgt actacaagga 2160 agaagggcag caggagaatg ggcccatttt
cttggatacc aaggacctac tctatactct 2220 cagtggctta gaccccagaa
gaaaatatca tgtgagactc ctggcttaca acaacataga 2280 cgatggctat
caggcagatc agactgtcag cactccagga tgcgtgtctg ttcgtgatcg 2340
catggtccct cctccaccac caccccacca tctctatgcg aaggctaaca cctcatcttc
2400 catcttcctg cactggagga ggcctgcatt caccgctgca caaatcatta
actacaccat 2460 ccgctgtaat cctgttggcc tgcagaatgc ttctttggtt
ctgtaccttc aaacatcaga 2520 aactcacatg ttggttcaag gtctagaacc
aaacaccaaa tacgaatttg ccgttcgatt 2580 acatgtggat cagctttcca
gtccttggag ccctgtagtc taccattcta ctcttccaga 2640 agcaccagca
ggcccaccag ttggagtaaa agtgacatta atagaggatg acactgccct 2700
ggtttcttgg aaaccccctg atggcccaga aacagttgtg acccgctata ctatcttata
2760 tgcatctagg aaggcctgga ttgcaggaga gtggcaggtc ttacaccgtg
aaggggcaat 2820 aaccatggct ttgctagaaa acttggtagc aggaaatgtg
tacattgtca agatatctgc 2880 atccaatgag gtgggagaag gacccttttc
aaattctgtg gagctggcag tacttccaaa 2940 ggaaacctct gaatcaaatc
agaggcccaa gcgtttagat tctgctgatg ccaaagttta 3000 ttcaggatat
taccatctgg accaaaaatc aatgactggc attgctgtag gtgttggcat 3060
agccttgacc tgcatcctca tctgtgttct catcttgata taccgaagta aagccaggaa
3120 atcatctgct tccaagacgg cacagaatgg aactcaacag ttacctcgta
ccagtgcctc 3180 cttagctagt ggaaatgagg taggaaagaa cctggaagga
gctgtaggaa atgaagaatc 3240 tttaatgcca atgatcatgc caaacagctt
cattgatgca aagggaggaa ctgacctgat 3300 aattaatagc tatggtccta
taattaaaaa caactctaag aaaaagtggt tttttttcca 3360 agactcaaag
aagatacaag ttgagcagcc tcaaagaaga tttactccag cggtctgctt 3420
ttaccagcca ggcaccactg tattaatcag tgatgaagac tcccctagct ccccaggtca
3480 gacaaccagc ttctcaagac cctttggtgt tgcagctgat acagaacatt
cagcaaatag 3540 tgaaggcagc catgagactg gggattctgg gcggttttct
catgagtcca acgatgagat 3600 acatctgtcc tcagttataa gtaccacacc
ccccaacctc tgattctttc actggcagtg 3660 attcaggtgg agattccgca
ttgaggaagt gtgaagaccc tgctgtgtca tctgttagtg 3720 agcagacttc
ctccttagtt ctgcagccgc catctgccat gctatgcttt gataaaaatg 3780
attttccaat ctagacggcc atgctcaggt attctcacca ttaaatctgt tcgaaggaca
3840 atgaacaggg aaccaaaaaa aaaaaaaaaa aaaa 3874
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