loadpatents
Patent applications and USPTO patent grants for Valenzuela; David M..The latest application filed is for "targeted modification of rat genome".
Patent | Date |
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Targeted Modification Of Rat Genome App 20210301301 - Lee; Jeffrey D. ;   et al. | 2021-09-30 |
Genetic Modification Of Rats App 20210130846 - Lee; Jeffrey D. ;   et al. | 2021-05-06 |
Methods of modifying genes in eukaryotic cells Grant 10,988,776 - Economides , et al. April 27, 2 | 2021-04-27 |
Targeted modification of rat genome Grant 10,975,390 - Lee , et al. April 13, 2 | 2021-04-13 |
Genetic modification of rats Grant 10,894,965 - Lee , et al. January 19, 2 | 2021-01-19 |
Non-human Animals Having A Hexanucleotide Repeat Expansion In A C9orf72 Locus App 20200370054 - Heslin; David ;   et al. | 2020-11-26 |
Non-human animals having a hexanucleotide repeat expansion in a C9ORF72 locus Grant 10,781,453 - Heslin , et al. Sept | 2020-09-22 |
Methods And Compositions For The Targeted Modification Of A Genome App 20200291425 - Frendewey; David ;   et al. | 2020-09-17 |
Methods and compositions for the targeted modification of a mouse ES cell genome Grant 10,711,280 - Frendewey , et al. | 2020-07-14 |
Nuclease-mediated Dna Assembly App 20200208161 - Schoenherr; Chris ;   et al. | 2020-07-02 |
Mice that produce hybrid antibodies Grant 10,640,800 - Murphy , et al. | 2020-05-05 |
Nuclease-mediated DNA assembly Grant 10,626,402 - Schoenherr , et al. | 2020-04-21 |
Mice that produce hybrid antibodies Grant 10,584,364 - Murphy , et al. | 2020-03-10 |
Genetically modified mice that produce hybrid antibodies Grant 10,526,630 - Murphy , et al. J | 2020-01-07 |
Methods And Compositions For Targeted Genetic Modification Using Paired Guide Rnas App 20200002730 - Frendewey; David ;   et al. | 2020-01-02 |
Methods And Compositions For Targeted Genetic Modification Using Paired Guide Rnas App 20200002731 - Frendewey; David ;   et al. | 2020-01-02 |
Methods And Compositions For Generating Or Maintaining Pluripotent Cells App 20190382730 - Kuno; Junko ;   et al. | 2019-12-19 |
Methods and compositions for targeted genetic modification using paired guide RNAs Grant 10,457,960 - Frendewey , et al. Oc | 2019-10-29 |
Targeted Modification Of Rat Genome App 20190323032 - Lee; Jeffrey D. ;   et al. | 2019-10-24 |
Genetic Modification Of Rats App 20190316149 - Lee; Jeffrey D. ;   et al. | 2019-10-17 |
Methods and compositions for generating or maintaining pluripotent cells Grant 10,428,310 - Kuno , et al. October 1, 2 | 2019-10-01 |
Targeted modification of rat genome Grant 10,385,359 - Lee , et al. A | 2019-08-20 |
Mouse embryonic stem cells comprising a hybrid heavy chain immunoglobulin locus Grant 10,378,039 - Murphy , et al. A | 2019-08-13 |
Mice that produce hybrid antibodies Grant 10,378,038 - Murphy , et al. A | 2019-08-13 |
Methods of making a nucleic acid encoding a human variable region Grant 10,378,037 - Murphy , et al. A | 2019-08-13 |
Mice that produce hybrid antibodies Grant 10,378,040 - Murphy , et al. A | 2019-08-13 |
Methods And Compositions For Modifying A Targeted Locus App 20190225992 - Auerbach; Wojtek ;   et al. | 2019-07-25 |
Non-human Animals Having A Disruption In A C9orf72 Locus App 20190216062 - Atanasio; Amanda ;   et al. | 2019-07-18 |
Compositions and methods for modifying cells Grant 10,344,299 - Economides , et al. July 9, 2 | 2019-07-09 |
Nuclease-mediated Dna Assembly App 20190194668 - Schoenherr; Chris ;   et al. | 2019-06-27 |
Genetic modification of rats Grant 10,329,582 - Lee , et al. | 2019-06-25 |
Nuclease-mediated targeting with large targeting vectors Grant 10,301,646 - Frendewey , et al. | 2019-05-28 |
Methods and compositions for modifying a targeted locus Grant 10,294,494 - Auerbach , et al. | 2019-05-21 |
Non-human animals having a disruption in a C9ORF72 locus Grant 10,285,388 - Atanasio , et al. | 2019-05-14 |
Stem Cells For Modeling Type 2 Diabetes App 20190136201 - Gong; Guochun ;   et al. | 2019-05-09 |
Nuclease-mediated DNA assembly Grant 10,273,488 - Schoenherr , et al. | 2019-04-30 |
Methods And Compositions For The Targeted Modification Of A Genome App 20190112619 - Frendewey; David ;   et al. | 2019-04-18 |
Methods of modifying eukaryotic cells Grant 10,227,625 - Murphy , et al. | 2019-03-12 |
Methods and compositions for the targeted modification of a mouse embryonic stem cell genome Grant 10,208,317 - Frendewey , et al. Feb | 2019-02-19 |
Stem cells for modeling type 2 diabetes Grant 10,196,613 - Gong , et al. Fe | 2019-02-05 |
Methods Of Modifying Genes In Eukaryotic Cells App 20180371493 - Economides; Aris N. ;   et al. | 2018-12-27 |
Methods and compositions for modifying a targeted locus Grant 10,106,820 - Auerbach , et al. October 23, 2 | 2018-10-23 |
Methods And Compositions For Targeted Genetic Modifications And Methods Of Use App 20180251784 - Frendewey; David ;   et al. | 2018-09-06 |
Methods and compositions for generating a mouse Grant 10,039,269 - Poueymirou , et al. August 7, 2 | 2018-08-07 |
Non-human Animals Having A Hexanucleotide Repeat Expansion In A C9orf72 Locus App 20180094267 - Heslin; David ;   et al. | 2018-04-05 |
Methods for producing a mouse XY embryonic (ES) cell line capable of producing a fertile XY female mouse in an F0 generation Grant 9,902,971 - Frendewey , et al. February 27, 2 | 2018-02-27 |
Nuclease-Mediated Targeting With Large Targeting Vectors App 20180037910 - Frendewey; David ;   et al. | 2018-02-08 |
Nuclease-mediated Dna Assembly App 20180002708 - Schoenherr; Chris ;   et al. | 2018-01-04 |
Nuclease-mediated targeting with large targeting vectors Grant 9,834,786 - Frendewey , et al. December 5, 2 | 2017-12-05 |
Methods And Compositions For Generating A Mouse App 20170295762 - Poueymirou; William ;   et al. | 2017-10-19 |
Compositions and Methods for Modifying Cells App 20170260544 - Economides; Aris N. ;   et al. | 2017-09-14 |
miRNA-regulated differentiation-dependent self-deleting cassette Grant 9,745,598 - Frendewey , et al. August 29, 2 | 2017-08-29 |
Nuclease-mediated DNA assembly Grant 9,738,897 - Schoenherr , et al. August 22, 2 | 2017-08-22 |
Methods and compositions for generating a mouse Grant 9,730,434 - Poueymirou , et al. August 15, 2 | 2017-08-15 |
Methods And Compositions For Modifying A Targeted Locus App 20170211099 - Auerbach; Wojtek ;   et al. | 2017-07-27 |
Targeted Modification Of Rat Genome App 20170204430 - Lee; Jeffrey D. ;   et al. | 2017-07-20 |
Methods of making a nucleic acid encoding a human variable region Grant 9,708,635 - Murphy , et al. July 18, 2 | 2017-07-18 |
Method for detecting the replacement of an endogenous allele with a modified allele by homologous recombination in a mouse ES cell Grant 9,677,129 - Economides , et al. June 13, 2 | 2017-06-13 |
Promoter-regulated differentiation-dependent self-deleting cassette Grant 9,677,086 - Frendewey , et al. June 13, 2 | 2017-06-13 |
Lincrna-deficient Non-human Animals App 20170071173 - Lai; Ka-Man Venus ;   et al. | 2017-03-16 |
Methods And Compositions For The Targeted Modification Of A Genome App 20170067078 - Frendewey; David ;   et al. | 2017-03-09 |
Nuclease-mediated DNA assembly Grant 9,580,715 - Schoenherr , et al. February 28, 2 | 2017-02-28 |
Genetic Modification Of Rats App 20170037429 - Lee; Jeffrey D. ;   et al. | 2017-02-09 |
IncRNA-knockout mice Grant 9,554,564 - Lai , et al. January 31, 2 | 2017-01-31 |
Methods and compositions for the targeted modification of a mouse genome Grant 9,546,384 - Frendewey , et al. January 17, 2 | 2017-01-17 |
Methods of modifying eukaryotic cells Grant 9,528,136 - Murphy , et al. December 27, 2 | 2016-12-27 |
Non-human Animals Having A Disruption In A C9orf72 Locus App 20160345547 - Atanasio; Amanda ;   et al. | 2016-12-01 |
ES Cell-Derived Mice From Diploid Host Embryo Injection App 20160316728 - Poueymirou; William ;   et al. | 2016-11-03 |
Mice That Produce Hybrid Antibodies App 20160316731 - Murphy; Andrew J. ;   et al. | 2016-11-03 |
Methods And Compositions For Generating A Mouse App 20160316729 - Poueymirou; William ;   et al. | 2016-11-03 |
Promoter-regulated Differentiation-dependent Self-deleting Cassette App 20160304903 - Frendewey; David ;   et al. | 2016-10-20 |
Methods and compositions for generating a mouse Grant 9,414,575 - Poueymirou , et al. August 16, 2 | 2016-08-16 |
Promoter-regulated differentiation-dependent self-deleting cassette Grant 9,410,163 - Frendewey , et al. August 9, 2 | 2016-08-09 |
Methods of producing hybrid antibodies Grant 9,388,446 - Murphy , et al. July 12, 2 | 2016-07-12 |
Methods of producing hybrid antibodies Grant 9,382,567 - Murphy , et al. July 5, 2 | 2016-07-05 |
Methods of producing hybrid antibodies Grant 9,376,699 - Murphy , et al. June 28, 2 | 2016-06-28 |
Stem Cells For Modeling Type 2 Diabetes App 20160177273 - Gong; Guochun ;   et al. | 2016-06-23 |
Genetically modified mice that produce hybrid antibodies Grant 9,371,553 - Murphy , et al. June 21, 2 | 2016-06-21 |
miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE App 20160150767 - Frendewey; David ;   et al. | 2016-06-02 |
Methods of producing hybrid antibodies Grant 9,353,394 - Murphy , et al. May 31, 2 | 2016-05-31 |
Methods And Compositions For Targeted Genetic Modification Using Paired Guide Rnas App 20160145646 - Frendewey; David ;   et al. | 2016-05-26 |
Nuclease-mediated Dna Assembly App 20160115486 - Schoenherr; Chris ;   et al. | 2016-04-28 |
Methods And Compositions For Generating Or Maintaining Pluripotent Cells App 20160108369 - Kuno; Junko ;   et al. | 2016-04-21 |
Genetic Modification Of Rats App 20160108360 - Lee; Jeffrey D. ;   et al. | 2016-04-21 |
Methods And Compositions For The Targeted Modification Of A Genome App 20160060657 - Frendewey; David ;   et al. | 2016-03-03 |
MiRNA-regulated differentiation-dependent self-deleting cassette Grant 9,267,152 - Frendewey , et al. February 23, 2 | 2016-02-23 |
Methods And Compositions For Targeted Genetic Modifications And Methods Of Use App 20160046960 - Frendewey; David ;   et al. | 2016-02-18 |
Methods and compositions for the targeted modification of a genome Grant 9,228,208 - Frendewey , et al. January 5, 2 | 2016-01-05 |
Methods And Compositions For Modifying A Targeted Locus App 20150376650 - Auerbach; Wojtek ;   et al. | 2015-12-31 |
Methods And Compositions For Targeted Genetic Modifications And Methods Of Use App 20150376651 - Frendewey; David ;   et al. | 2015-12-31 |
Nuclease-mediated Dna Assembly App 20150376628 - Schoenherr; Chris ;   et al. | 2015-12-31 |
miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE App 20150291978 - Frendewey; David ;   et al. | 2015-10-15 |
miRNA-regulated differentiation-dependent self-deleting cassette Grant 9,096,870 - Frendewey , et al. August 4, 2 | 2015-08-04 |
Methods and Compositions for the Targeted Modification of a Genome App 20150159174 - Frendewey; David ;   et al. | 2015-06-11 |
Methods And Compositions For The Targeted Modification Of A Genome App 20150159175 - Frendewey; David ;   et al. | 2015-06-11 |
Promoter-regulated Differentiation-dependent Self-deleting Cassette App 20150099296 - Frendewey; David ;   et al. | 2015-04-09 |
lincRNA-DEFICIENT NON-HUMAN ANIMALS App 20150047062 - Lai; Ka-Man Venus ;   et al. | 2015-02-12 |
Promoter-regulated differentiation-dependent self-deleting cassette Grant 8,946,504 - Frendewey , et al. February 3, 2 | 2015-02-03 |
Promoter-regulated differentiation-dependent self-deleting cassette Grant 8,946,505 - Frendewey , et al. February 3, 2 | 2015-02-03 |
Methods And Compositions For Generating A Mouse App 20140331340 - Poueymirou; William ;   et al. | 2014-11-06 |
Targeted Modification Of Rat Genome App 20140309487 - Lee; Jeffrey D. ;   et al. | 2014-10-16 |
Targeted Modification Of Rat Genome App 20140310828 - Lee; Jeffrey D. ;   et al. | 2014-10-16 |
Method for genetically modifying isolated non-human mammalian cell by homologous recombination Grant 8,846,402 - Economides , et al. September 30, 2 | 2014-09-30 |
Conditioned culture media Grant 8,816,150 - Poueymirou , et al. August 26, 2 | 2014-08-26 |
Genetic Modification Of Rats App 20140235933 - Lee; Jeffrey D. ;   et al. | 2014-08-21 |
Cloned Non-human Animals Free Of Selective Markers App 20140221734 - Gong; Guochun ;   et al. | 2014-08-07 |
Hybrid antibodies comprising human variable regions and mouse constant regions produced in a genetically modified mouse Grant 8,791,323 - Murphy , et al. July 29, 2 | 2014-07-29 |
Promoter-regulated Differentiation-dependent Self-deleting Cassette App 20140199761 - Frendewey; David ;   et al. | 2014-07-17 |
miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE App 20140189900 - Frendewey; David ;   et al. | 2014-07-03 |
Compositions and Methods for Modifying Cells App 20140178879 - ECONOMIDES; ARIS N. ;   et al. | 2014-06-26 |
Method for genetically modifying mouse embryonic stem cell by homologous recombination Grant 8,759,105 - Economides , et al. June 24, 2 | 2014-06-24 |
Methods Of Modifying Genes In Eukaryotic Cells App 20140155689 - Economides; Aris N. ;   et al. | 2014-06-05 |
MiRNA-regulated differentiation-dependent self-deleting cassette Grant 8,697,851 - Frendewey , et al. April 15, 2 | 2014-04-15 |
Parental Cell Lines for Making Cassette-Free F1 Progeny App 20140075586 - Gong; Guochun ;   et al. | 2014-03-13 |
Nuclease-Mediated Targeting With Large Targeting Vectors App 20130309670 - Frendewey; David ;   et al. | 2013-11-21 |
Promoter-regulated Differentiation-dependent Self-deleting Cassette App 20130312128 - FRENDEWEY; David ;   et al. | 2013-11-21 |
Promoter-regulated Differentiation-dependent Self-deleting Cassette App 20130312129 - FRENDEWEY; David ;   et al. | 2013-11-21 |
Promoter-regulated differentiation-dependent self-deleting cassette Grant 8,518,392 - Frendewey , et al. August 27, 2 | 2013-08-27 |
Methods of Modifying Eukaryotic Cells App 20130137101 - Economides; Aris N. ;   et al. | 2013-05-30 |
miRNA-Regulated Differentiation-Dependent Self-Deleting Cassette App 20130095565 - FRENDEWEY; David ;   et al. | 2013-04-18 |
miRNA-regulated differentiation-dependent self-deleting cassette Grant 8,354,389 - Frendewey , et al. January 15, 2 | 2013-01-15 |
miRNA-Regulated Differentiation-Dependent Self-Deleting Cassette App 20110041196 - FRENDEWEY; David ;   et al. | 2011-02-17 |
Promoter-Regulated Differentiation-Dependent Self-Deleting Cassette App 20110041197 - FRENDEWEY; DAVID ;   et al. | 2011-02-17 |
Method for making homozygous genetic modifications Grant 7,659,442 - Poueymirou , et al. February 9, 2 | 2010-02-09 |
ES Cell-Derived Mice From Diploid Host Embryo Injection App 20090271884 - POUEYMIROU; William ;   et al. | 2009-10-29 |
Method for making genetic modifications Grant 7,576,259 - Poueymirou , et al. August 18, 2 | 2009-08-18 |
Methods of modifying eukaryotic cells App 20090055943 - Economides; Aris N. ;   et al. | 2009-02-26 |
Conditioned culture media App 20080078000 - Poueymirou; William ;   et al. | 2008-03-27 |
Method for making homozygous genetic modifications App 20080078001 - Poueymirou; William ;   et al. | 2008-03-27 |
Method for making genetic modifications App 20080028479 - Poueymirou; William ;   et al. | 2008-01-31 |
Methods of modifying genes in eukaryotic cells App 20070275466 - Economides; Aris N. ;   et al. | 2007-11-29 |
Method for generating an animal homozygous for a genetic modification Grant 7,294,754 - Poueymirou , et al. November 13, 2 | 2007-11-13 |
Therapeutic method for treating bone formation diseases Grant 7,285,532 - Economides , et al. October 23, 2 | 2007-10-23 |
Morphogenic protein Grant 7,241,739 - Valenzuela , et al. July 10, 2 | 2007-07-10 |
Genome mutation by intron insertion into an embryonic stem cell genome Grant 7,205,148 - Economides , et al. April 17, 2 | 2007-04-17 |
Method for generating an animal homozygous for a genetic modification App 20060085866 - Poueymirou; William ;   et al. | 2006-04-20 |
Methods for identifying a cell or an embryo carrying a Y chromosome App 20060064770 - Frendewey; David ;   et al. | 2006-03-23 |
Methods of modifying eukaryotic cells App 20050144655 - Economides, Aris N. ;   et al. | 2005-06-30 |
Method of improving gene targeting using a ubiquitin promoter App 20050101017 - Auerbach, Wojtek ;   et al. | 2005-05-12 |
TIE-2 ligand-4 Grant 6,881,395 - Valenzuela , et al. April 19, 2 | 2005-04-19 |
Tyrosine kinase receptors and ligands Grant 6,852,838 - Valenzuela , et al. February 8, 2 | 2005-02-08 |
Tie-2 ligand-3 Grant 6,846,914 - Valenzuela , et al. January 25, 2 | 2005-01-25 |
Methods of modifying genes in eukaryotic cells App 20050003543 - Economides, Aris N. ;   et al. | 2005-01-06 |
Therapeutic method for treating bone formation diseases App 20040132661 - Economides, Aris N. ;   et al. | 2004-07-08 |
Novel morphogenic protein App 20030199042 - Valenzuela, David M. ;   et al. | 2003-10-23 |
Morphogenic proteins Grant 6,610,510 - Valenzuela , et al. August 26, 2 | 2003-08-26 |
Methods of modifying eukaryotic cells Grant 6,586,251 - Economides , et al. July 1, 2 | 2003-07-01 |
Novel ligands, methods of making and uses thereof App 20030064470 - Valenzuela, David M. ;   et al. | 2003-04-03 |
Novel ligands, methods of making and uses thereof App 20030059887 - Valenzuela, David M. ;   et al. | 2003-03-27 |
Novel tyrosine kinase receptors and ligands App 20020164702 - Valenzuela, David M. ;   et al. | 2002-11-07 |
Novel orphan receptors App 20020160451 - Masiakowski, Piotr J. ;   et al. | 2002-10-31 |
Methods of modifying eukaryotic cells App 20020106628 - Economides, Aris N. ;   et al. | 2002-08-08 |
Dorsal tissue affecting factor and compositions App 20020102643 - Valenzuela, David M. ;   et al. | 2002-08-01 |
Tie ligand-3, methods of making and uses thereof Grant 5,851,797 - Valenzuela , et al. December 22, 1 | 1998-12-22 |
Hybridoma cell lines and antibodies that bind noggin Grant 5,821,124 - Valenzuela , et al. October 13, 1 | 1998-10-13 |
Tyrosine kinase receptors and ligands Grant 5,814,478 - Valenzuela , et al. September 29, 1 | 1998-09-29 |
Monoclonal antibodies recognizing parathyroid hormone-like protein Grant 5,217,896 - Kramer , et al. June 8, 1 | 1993-06-08 |
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