loadpatents
Patent applications and USPTO patent grants for Manoharan; Muthiah.The latest application filed is for "delivery of oligonucleotides to the striatum".
Patent | Date |
---|---|
Delivery Of Oligonucleotides To The Striatum App 20220307024 - Nair; Jayaprakash K. ;   et al. | 2022-09-29 |
Modified RNA Agents with Reduced Off-Target Effect App 20220290145 - MATSUDA; Shigeo ;   et al. | 2022-09-15 |
Modified double-stranded RNA agents Grant 11,427,822 - Maier , et al. August 30, 2 | 2022-08-30 |
Lipid containing formulations Grant 11,420,931 - Manoharan , et al. August 23, 2 | 2022-08-23 |
Reversir Tm Compounds App 20220259589 - JADHAV; Vasant ;   et al. | 2022-08-18 |
Biodegradable Lipids For The Delivery Of Active Agents App 20220249670 - Maier; Martin ;   et al. | 2022-08-11 |
Modified RNAi agents Grant 11,406,716 - Rajeev , et al. August 9, 2 | 2022-08-09 |
Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Grant 11,408,001 - Fitzgerald , et al. August 9, 2 | 2022-08-09 |
Modified double-stranded RNA agents Grant 11,401,517 - Maier , et al. August 2, 2 | 2022-08-02 |
Biodegradable lipids for the delivery of active agents Grant 11,400,158 - Maier , et al. August 2, 2 | 2022-08-02 |
Biodegradable lipids for the delivery of active agents Grant 11,382,979 - Maier , et al. July 12, 2 | 2022-07-12 |
HIGH DENSITY LIPOPROTEIN BINDING PROTEIN (HDLBP/VIGILIN) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20220202847 - Manoharan; Muthiah ;   et al. | 2022-06-30 |
Biodegradable Lipids For The Delivery Of Active Agents App 20220175930 - Maier; Martin ;   et al. | 2022-06-09 |
Biodegradable Lipids For The Delivery Of Active Agents App 20220175929 - Maier; Martin ;   et al. | 2022-06-09 |
Biodegradable Lipids For The Delivery Of Active Agents App 20220175928 - Maier; Martin ;   et al. | 2022-06-09 |
Compositions Comprising Alternating 2'-modified Nucleosides For Use In Gene Modulation App 20220162603 - Allerson; Charles ;   et al. | 2022-05-26 |
Carbohydrate Conjugates As Delivery Agents For Oligonucleotides App 20220143189 - MANOHARAN; Muthiah ;   et al. | 2022-05-12 |
Reversir Tm Compounds App 20220127604 - JADHAV; Vasant ;   et al. | 2022-04-28 |
Extrahepatic Delivery App 20220125823 - NAIR; Jayaprakash K. ;   et al. | 2022-04-28 |
Biodegradable Lipids For The Delivery Of Active Agents App 20220125927 - Maier; Martin ;   et al. | 2022-04-28 |
Modified iRNA agents Grant 11,312,957 - Manoharan , et al. April 26, 2 | 2022-04-26 |
Biodegradable Lipids For The Delivery Of Active Agents App 20220111053 - MAIER; MARTIN ;   et al. | 2022-04-14 |
Biodegradable Lipids For The Delivery Of Active Agents App 20220105187 - Maier; Martin ;   et al. | 2022-04-07 |
Multi-targeted Single Entity Conjugates App 20220106593 - JADHAV; Vasant ;   et al. | 2022-04-07 |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20220090068 - Fitzgerald; Kevin ;   et al. | 2022-03-24 |
Modified Double-stranded Rna Agents App 20220056448 - MAIER; Martin ;   et al. | 2022-02-24 |
Compositions And Methods For Inhibition Of Expression Of Apolipoprotein C-iii (apoc3) Genes App 20220049253 - Bettencourt; Brian ;   et al. | 2022-02-17 |
Biodegradable lipids for the delivery of active agents Grant 11,246,933 - Maier , et al. February 15, 2 | 2022-02-15 |
Lipid Compositions App 20220040308 - Manoharan; Muthiah ;   et al. | 2022-02-10 |
Lipids And Compositions For The Delivery Of Therapeutics App 20220023427 - Manoharan; Muthiah ;   et al. | 2022-01-27 |
Carbohydrate Conjugates As Delivery Agents For Oligonucleotides App 20220008541 - MANOHARAN; Muthiah ;   et al. | 2022-01-13 |
Modified Double-stranded Rna Agents App 20220002727 - MAIER; Martin ;   et al. | 2022-01-06 |
High density lipoprotein binding protein (Hdlbp/Vigilin) iRNA compositions and methods of use thereof Grant 11,207,342 - Manoharan , et al. December 28, 2 | 2021-12-28 |
Complement component C5 iRNA compositions and methods of use thereof Grant 11,162,098 - Fitzgerald , et al. November 2, 2 | 2021-11-02 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20210317452 - Sehgal; Alfica ;   et al. | 2021-10-14 |
Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Grant 11,142,766 - Fitzgerald , et al. October 12, 2 | 2021-10-12 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 11,110,174 - Manoharan , et al. September 7, 2 | 2021-09-07 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20210269796 - Schlegel; Mark K. ;   et al. | 2021-09-02 |
iRNA AGENTS WITH BIOCLEAVABLE TETHERS App 20210254065 - MANOHARAN; Muthiah ;   et al. | 2021-08-19 |
SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20210254063 - Akinc; Akin ;   et al. | 2021-08-19 |
Compositions And Methods For Improving Strand Biased App 20210238594 - PARMAR; Rubina G. ;   et al. | 2021-08-05 |
Modified Rna Agents With Reduced Off-target Effect App 20210238595 - MATSUDA; Shigeo ;   et al. | 2021-08-05 |
Lipids and compositions for the delivery of therapeutics Grant 11,077,197 - Manoharan , et al. August 3, 2 | 2021-08-03 |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation Grant 11,078,485 - Allerson , et al. August 3, 2 | 2021-08-03 |
Biodegradable lipids for the delivery of active agents Grant 11,071,784 - Maier , et al. July 27, 2 | 2021-07-27 |
Hepatitis B virus (HBV) iRNA compositions and methods of use thereof Grant 11,060,091 - Hinkle , et al. July 13, 2 | 2021-07-13 |
Chirally-enriched Double-stranded Rna Agents App 20210207144 - MANOHARAN; Muthiah ;   et al. | 2021-07-08 |
Multi-targeted single entity conjugates Grant 11,053,495 - Jadhav , et al. July 6, 2 | 2021-07-06 |
Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Grant 11,034,958 - Fitzgerald , et al. June 15, 2 | 2021-06-15 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20210162053 - Manoharan; Muthiah ;   et al. | 2021-06-03 |
iRNA agents with biocleavable tethers Grant 11,015,194 - Manoharan , et al. May 25, 2 | 2021-05-25 |
Serpina1 iRNA compositions and methods of use thereof Grant 10,995,336 - Schlegel , et al. May 4, 2 | 2021-05-04 |
APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20210108203 - Fitzgerald; Kevin ;   et al. | 2021-04-15 |
Oligonucleotides Comprising Acyclic And Abasic Nucleosides And Analogs App 20210087219 - MANOHARAN; Muthiah ;   et al. | 2021-03-25 |
Lipid compositions Grant 10,953,095 - Manoharan , et al. March 23, 2 | 2021-03-23 |
Myostatin iRNA compositions and methods of use thereof Grant 10,933,081 - Jadhav , et al. March 2, 2 | 2021-03-02 |
Serpina1 iRNA compositions and methods of use thereof Grant 10,920,223 - Sehgal , et al. February 16, 2 | 2021-02-16 |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs Grant 10,913,767 - Manoharan , et al. February 9, 2 | 2021-02-09 |
Modified Double-stranded Rna Agents App 20210017519 - MAIER; Martin ;   et al. | 2021-01-21 |
Lipid Containing Formulations App 20200361854 - Manoharan; Muthiah ;   et al. | 2020-11-19 |
Lipids and compositions for the delivery of therapeutics Grant 10,835,612 - Manoharan , et al. November 17, 2 | 2020-11-17 |
MODIFIED RNAi AGENTS App 20200353097 - RAJEEV; Kallanthottathil G. ;   et al. | 2020-11-12 |
Lipids and compositions for the delivery of therapeutics Grant 10,821,186 - Manoharan , et al. November 3, 2 | 2020-11-03 |
Oligonucleotide-ligand conjugates and process for their preparation Grant 10,808,246 - Manoharan , et al. October 20, 2 | 2020-10-20 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 10,806,791 - Manoharan , et al. October 20, 2 | 2020-10-20 |
Rnai Agents, Compositions And Methods Of Use Thereof For Treating Transthyretin (ttr) Associated Diseases App 20200318111 - Rajeev; Kallanthottathil G. ;   et al. | 2020-10-08 |
Carbohydrate Conjugates As Delivery Agents For Oligonucleotides App 20200297853 - MANOHARAN; Muthiah ;   et al. | 2020-09-24 |
HEPATITIS D VIRUS (HDV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20200291405 - Hinkle; Gregory ;   et al. | 2020-09-17 |
Methods And Compositions For Detecting Anti-drug Antibodies App 20200291449 - Rajeev; Kallanthottathil G. ;   et al. | 2020-09-17 |
Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes App 20200263176 - Bettencourt; Brian ;   et al. | 2020-08-20 |
Therapeutic Compositions App 20200255833 - MANOHARAN; Muthiah ;   et al. | 2020-08-13 |
SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20200216844 - Akinc; Akin ;   et al. | 2020-07-09 |
APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20200199591 - Fitzgerald; Kevin ;   et al. | 2020-06-25 |
Serpina1 iRNA compositions and methods of use thereof Grant 10,683,504 - Sehgal , et al. | 2020-06-16 |
Modified iRNA agents Grant 10,676,740 - Manoharan , et al. | 2020-06-09 |
Modified RNAi agents Grant 10,668,170 - Rajeev , et al. | 2020-06-02 |
Therapeutic compositions Grant 10,669,544 - Manoharan , et al. | 2020-06-02 |
HEPATITIS B VIRUS (HBV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20200140864 - Hinkle; Gregory ;   et al. | 2020-05-07 |
Myostatin Irna Compositions And Methods Of Use Thereof App 20200138847 - Jadhav; Vasant R. ;   et al. | 2020-05-07 |
Lipid Compositions App 20200138955 - Manoharan; Muthiah ;   et al. | 2020-05-07 |
Hepatitis D virus (HDV) iRNA compositions and methods of use thereof Grant 10,640,770 - Hinkle , et al. | 2020-05-05 |
Modified double-stranded RNA agents Grant 10,612,024 - Maier , et al. | 2020-04-07 |
Modified double-stranded RNA agents Grant 10,612,027 - Maier , et al. | 2020-04-07 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20200080085 - Sehgal; Alfica ;   et al. | 2020-03-12 |
APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20200080088 - Fitzgerald; Kevin ;   et al. | 2020-03-12 |
RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases Grant 10,570,391 - Rajeev , et al. Feb | 2020-02-25 |
Monomers and oligonucleotides comprising cycloaddition adduct(s) Grant 10,550,386 - Manoharan , et al. Fe | 2020-02-04 |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20200032259 - Fitzgerald; Kevin ;   et al. | 2020-01-30 |
Compositions Comprising Alternating 2'-modified Nucleosides For Use In Gene Modulation App 20200017855 - Allerson; Charles ;   et al. | 2020-01-16 |
Hepatitis B virus (HBV) iRNA compositions and methods of use thereof Grant 10,513,703 - Hinkle , et al. Dec | 2019-12-24 |
Biodegradable Lipids For The Delivery Of Active Agents App 20190374646 - Maier; Martin ;   et al. | 2019-12-12 |
MODIFIED iRNA AGENTS App 20190345498 - MANOHARAN; Muthiah ;   et al. | 2019-11-14 |
Lipid compositions Grant 10,456,473 - Manoharan , et al. Oc | 2019-10-29 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20190316127 - Schlegel; Mark K. ;   et al. | 2019-10-17 |
Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Grant 10,407,679 - Fitzgerald , et al. Sept | 2019-09-10 |
Therapeutic Compositions App 20190264207 - MANOHARAN; Muthiah ;   et al. | 2019-08-29 |
Oligonucleotide end caps Grant 10,385,337 - Manoharan , et al. A | 2019-08-20 |
Modified Double-stranded Rna Agents App 20190241893 - MAIER; Martin ;   et al. | 2019-08-08 |
Modified Double-stranded Rna Agents App 20190241891 - Maier; Martin ;   et al. | 2019-08-08 |
Biodegradable lipids for the delivery of active agents Grant 10,369,226 - Maier , et al. | 2019-08-06 |
Carbohydrate Conjugates As Delivery Agents For Oligonucleotides App 20190184018 - MANOHARAN; Muthiah ;   et al. | 2019-06-20 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20190167800 - Manoharan; Muthiah ;   et al. | 2019-06-06 |
Carbohydrate Conjugated Rna Agents And Process For Their Preparation App 20190134206 - Nair; Jayaprakash K. ;   et al. | 2019-05-09 |
Therapeutic compositions Grant 10,273,477 - Manoharan , et al. | 2019-04-30 |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation Grant 10,266,825 - Allerson , et al. | 2019-04-23 |
Biodegradable lipids for the delivery of active agents Grant 10,266,484 - Manoharan , et al. | 2019-04-23 |
Targeting Lipids App 20190099493 - Manoharan; Muthiah ;   et al. | 2019-04-04 |
Modified double-stranded RNA agents Grant 10,233,448 - Maier , et al. | 2019-03-19 |
Chemical Modifications Of Monomers And Oligonucleotides With Cycloaddition App 20190048344 - Manoharan; Muthiah ;   et al. | 2019-02-14 |
HIGH DENSITY LIPOPROTEIN BINDING PROTEIN (HDLBP/VIGILIN) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20190038658 - Manoharan; Muthiah ;   et al. | 2019-02-07 |
MODIFIED RNAi AGENTS App 20190038768 - RAJEEV; Kallanthottathil G. ;   et al. | 2019-02-07 |
Compositions For Nucleic Acid Delivery App 20180369384 - Manoharan; Muthiah ;   et al. | 2018-12-27 |
Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes App 20180362978 - Bettencourt; Brian ;   et al. | 2018-12-20 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20180346910 - Sehgal; Alfica ;   et al. | 2018-12-06 |
5' phosphate mimics Grant 10,131,908 - Manoharan , et al. November 20, 2 | 2018-11-20 |
iRNA AGENTS WITH BIOCLEAVABLE TETHERS App 20180327744 - MANOHARAN; Muthiah ;   et al. | 2018-11-15 |
Carbohydrate Conjugates As Delivery Agents For Oligonucleotides App 20180326070 - MANOHARAN; Muthiah ;   et al. | 2018-11-15 |
PCSK9 iRNA compositions and methods of use thereof Grant 10,125,369 - Borodovsky , et al. November 13, 2 | 2018-11-13 |
iRNA agents with biocleavable tethers Grant 10,119,138 - Manoharan , et al. November 6, 2 | 2018-11-06 |
RNAi agents modified at the 4'-C position Grant 10,119,136 - Manoharan , et al. November 6, 2 | 2018-11-06 |
Lipids and compositions for the delivery of therapeutics Grant 10,117,941 - Manoharan , et al. November 6, 2 | 2018-11-06 |
Carbohydrate conjugated RNA agents and process for their preparation Grant 10,086,081 - Nair , et al. October 2, 2 | 2018-10-02 |
MODIFIED iRNA AGENTS App 20180258427 - MANOHARAN; Muthiah ;   et al. | 2018-09-13 |
Site-specific Delivery Of Nucleic Acids By Combining Targeting Ligands With Endosomolytic Components App 20180221494 - Manoharan; Muthiah ;   et al. | 2018-08-09 |
Methods And Compositions For Delivery Of Active Agents App 20180221510 - Manoharan; Muthiah ;   et al. | 2018-08-09 |
Multi-targeted Single Entity Conjugates App 20180208927 - JADHAV; Vasant ;   et al. | 2018-07-26 |
Serpina1 iRNA compositions and methods of use thereof Grant 10,030,244 - Sehgal , et al. July 24, 2 | 2018-07-24 |
PEGylated lipids and their use for drug delivery Grant 9,999,673 - Rajeev , et al. June 19, 2 | 2018-06-19 |
Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes Grant 9,970,006 - Bettencourt , et al. May 15, 2 | 2018-05-15 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20180125985 - Manoharan; Muthiah ;   et al. | 2018-05-10 |
Lipid Compositions App 20180104342 - Manoharan; Muthiah ;   et al. | 2018-04-19 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20180092971 - Manoharan; Muthiah ;   et al. | 2018-04-05 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20180064807 - Manoharan; Muthiah ;   et al. | 2018-03-08 |
Lipid Containing Formulations App 20180065918 - Manoharan; Muthiah ;   et al. | 2018-03-08 |
Biodegradable Lipids For The Delivery Of Active Agents App 20180065920 - Manoharan; Muthiah ;   et al. | 2018-03-08 |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components Grant 9,895,448 - Manoharan , et al. February 20, 2 | 2018-02-20 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20180043009 - Manoharan; Muthiah ;   et al. | 2018-02-15 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 9,867,882 - Manoharan , et al. January 16, 2 | 2018-01-16 |
MODIFIED RNAi AGENTS App 20180008724 - RAJEEV; Kallanthottathil G. ;   et al. | 2018-01-11 |
Compositions Comprising Alternating 2'-modified Nucleosides For Use In Gene Modulation App 20170369880 - Allerson; Charles ;   et al. | 2017-12-28 |
Reversir Tm Compounds App 20170369872 - JADHAV; Vasant ;   et al. | 2017-12-28 |
Complement component C5 iRNA compositions and methods of use thereof Grant 9,850,488 - Fitzgerald , et al. December 26, 2 | 2017-12-26 |
HEPATITIS B VIRUS (HBV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20170349900 - Hinkle; Gregory ;   et al. | 2017-12-07 |
HEPATITIS D VIRUS (HDV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20170349901 - Hinkle; Gregory ;   et al. | 2017-12-07 |
Targeting lipids Grant 9,814,777 - Manoharan , et al. November 14, 2 | 2017-11-14 |
Modified RNAi agents Grant 9,796,974 - Rajeev , et al. October 24, 2 | 2017-10-24 |
Therapeutic Compositions App 20170283801 - MANOHARAN; Muthiah ;   et al. | 2017-10-05 |
Modified Double-stranded Rna Agents App 20170275626 - MAIER; Martin ;   et al. | 2017-09-28 |
Phosphorous-linked oligomeric compounds and their use in gene modulation Grant 9,771,578 - Baker , et al. September 26, 2 | 2017-09-26 |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20170268005 - Fitzgerald; Kevin ;   et al. | 2017-09-21 |
Lipids and compositions for the delivery of therapeutics Grant 9,764,036 - Manoharan , et al. September 19, 2 | 2017-09-19 |
APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20170260527 - Fitzgerald; Kevin ;   et al. | 2017-09-14 |
5'-end derivatives Grant 9,725,479 - Manoharan , et al. August 8, 2 | 2017-08-08 |
Modified RNAi agents Grant 9,708,607 - Rajeev , et al. July 18, 2 | 2017-07-18 |
Lipids and compositions for the delivery of therapeutics Grant 9,707,292 - Manoharan , et al. July 18, 2 | 2017-07-18 |
Therapeutic compositions Grant 9,708,615 - Manoharan , et al. July 18, 2 | 2017-07-18 |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation Grant 9,708,610 - Allerson , et al. July 18, 2 | 2017-07-18 |
Di-aliphatic substituted pegylated lipids Grant 9,701,623 - Manoharan , et al. July 11, 2 | 2017-07-11 |
Complement component C5 iRNA compositions and methods of use thereof Grant 9,701,963 - Fitzgerald , et al. July 11, 2 | 2017-07-11 |
Lipid compositions Grant 9,694,077 - Manoharan , et al. July 4, 2 | 2017-07-04 |
Compositions for nucleic acid delivery Grant 9,687,550 - Manoharan , et al. June 27, 2 | 2017-06-27 |
Biodegradable lipids for the delivery of active agents Grant 9,682,922 - Manoharan , et al. June 20, 2 | 2017-06-20 |
Lipids and compositions for the delivery of therapeutics Grant 9,682,139 - Manoharan , et al. June 20, 2 | 2017-06-20 |
Lipid Formulation App 20170143631 - Chen; Jianxin ;   et al. | 2017-05-25 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20170114342 - Sehgal; Alfica ;   et al. | 2017-04-27 |
Monomers And Oligonucleotides Comprising Cycloaddition Adduct(s) App 20170107513 - MANOHARAN; Muthiah ;   et al. | 2017-04-20 |
Oligonucleotide End Caps App 20170107511 - MANOHARAN; Muthiah ;   et al. | 2017-04-20 |
Serapina1 iRNA compositions and methods of use thereof Grant 9,574,192 - Sehgal , et al. February 21, 2 | 2017-02-21 |
Methods And Compositions For Detecting Anti-drug Antibodies App 20170044591 - Rajeev; Kallanthottathil G. ;   et al. | 2017-02-16 |
Monomers and oligonucleotides comprising cycloaddition adduct(s) Grant 9,566,340 - Manoharan , et al. February 14, 2 | 2017-02-14 |
RNAi AGENTS MODIFIED AT THE 4'-C POSITION App 20170029815 - MANOHARAN; Muthiah ;   et al. | 2017-02-02 |
Oligonucleotide-ligand Conjugates And Process For Their Preparation App 20160376585 - MANOHARAN; Muthiah ;   et al. | 2016-12-29 |
iRNA AGENTS WITH BIOCLEAVABLE TETHERS App 20160376591 - MANOHARAN; Muthiah ;   et al. | 2016-12-29 |
Targeting Lipids App 20160375137 - Manoharan; Muthiah ;   et al. | 2016-12-29 |
Site-specific Delivery Of Nucleic Acids By Combining Targeting Ligands With Endosomolytic Components App 20160367687 - Manoharan; Muthiah ;   et al. | 2016-12-22 |
Rnai Agents, Compositions And Methods Of Use Thereof For Treating Transthyretin (ttr) Associated Diseases App 20160355817 - Rajeev; Kallanthottathil G. ;   et al. | 2016-12-08 |
Oligonucleotide end caps Grant 9,512,164 - Manoharan , et al. December 6, 2 | 2016-12-06 |
Nucleic Acid Chemical Modifications App 20160348110 - MANOHARAN; Muthiah ;   et al. | 2016-12-01 |
Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes App 20160333342 - Bettencourt; Brian ;   et al. | 2016-11-17 |
Methods And Compositions For Delivery Of Nucleic Acids App 20160317676 - Hope; Michael J. ;   et al. | 2016-11-03 |
iRNA agents with biocleavable tethers Grant 9,476,045 - Manoharan , et al. October 25, 2 | 2016-10-25 |
Compositions And Methods For Inhibiting Expression Of Mylip/idol Gene App 20160298122 - Bettencourt; Brian ;   et al. | 2016-10-13 |
Nucleic acid chemical modifications Grant 9,453,043 - Manoharan , et al. September 27, 2 | 2016-09-27 |
Ligand-conjugated monomers Grant 9,453,222 - Manoharan , et al. September 27, 2 | 2016-09-27 |
MODIFIED iRNA AGENTS App 20160264968 - MANOHARAN; Muthiah ;   et al. | 2016-09-15 |
SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20160257954 - Akinc; Akin ;   et al. | 2016-09-08 |
Methods And Compositions For Delivery Of Active Agents App 20160250354 - Manoharan; Muthiah ;   et al. | 2016-09-01 |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20160244763 - Fitzgerald; Kevin ;   et al. | 2016-08-25 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20160213785 - Manoharan; Muthiah ;   et al. | 2016-07-28 |
RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases Grant 9,399,775 - Rajeev , et al. July 26, 2 | 2016-07-26 |
Modified iRNA agents Grant 9,394,540 - Manoharan , et al. July 19, 2 | 2016-07-19 |
Lipid formulations Grant 9,394,234 - Chen , et al. July 19, 2 | 2016-07-19 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20160199485 - Manoharan; Muthiah ;   et al. | 2016-07-14 |
Serpinc1 iRNA compositions and methods of use thereof Grant 9,376,680 - Akinc , et al. June 28, 2 | 2016-06-28 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 9,370,582 - Manoharan , et al. June 21, 2 | 2016-06-21 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 9,370,581 - Manoharan , et al. June 21, 2 | 2016-06-21 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 9,352,048 - Manoharan , et al. May 31, 2 | 2016-05-31 |
Site specific delivery of nucleic acids by combining targeting ligands with endosomolytic components Grant 9,345,780 - Manoharan , et al. May 24, 2 | 2016-05-24 |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20160108401 - Fitzgerald; Kevin ;   et al. | 2016-04-21 |
Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes Grant 9,315,813 - Bettencourt , et al. April 19, 2 | 2016-04-19 |
Monomers And Oligonucleotides Comprising Cycloaddition Adduct(s) App 20160101189 - MANOHARAN; Muthiah ;   et al. | 2016-04-14 |
Modified iRNA agents Grant 9,290,760 - Rajeev , et al. March 22, 2 | 2016-03-22 |
Phosphorous-linked Oligomeric Compounds And Their Use In Gene Modulation App 20160076031 - Baker; Brenda F. ;   et al. | 2016-03-17 |
Therapeutic Compositions App 20160076040 - MANOHARAN; Muthiah ;   et al. | 2016-03-17 |
Compositions Comprising Alternating 2'-modified Nucleosides For Use In Gene Modulation App 20160053261 - Allerson; Charles ;   et al. | 2016-02-25 |
Carbohydrate Conjugates As Delivery Agents For Oligonucleotides App 20160051691 - MANOHARAN; Muthiah ;   et al. | 2016-02-25 |
Methods and compositions for delivery of active agents Grant 9,254,327 - Manoharan , et al. February 9, 2 | 2016-02-09 |
Complement component C5 iRNA compositions and methods of use thereof Grant 9,249,415 - Fitzgerald , et al. February 2, 2 | 2016-02-02 |
Chimeric Oligomeric Compounds And Their Use In Gene Modulation App 20160017324 - Baker; Brenda F. ;   et al. | 2016-01-21 |
SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20160017330 - Akinc; Akin ;   et al. | 2016-01-21 |
PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20160017335 - Borodovsky; Anna ;   et al. | 2016-01-21 |
Biodegradable Lipids For The Delivery Of Active Agents App 20160009637 - MANOHARAN; Muthiah ;   et al. | 2016-01-14 |
Lipids and compositions for the delivery of therapeutics Grant 9,220,683 - Manoharan , et al. December 29, 2 | 2015-12-29 |
Therapeutic compositions Grant 9,222,091 - Manoharan , et al. December 29, 2 | 2015-12-29 |
Monomers and oligonucleotides comprising cycloaddition adduct(s) Grant 9,198,972 - Manoharan , et al. December 1, 2 | 2015-12-01 |
Compositions and methods for inhibiting expression of Mylip/Idol gene Grant 9,198,983 - Bettencourt , et al. December 1, 2 | 2015-12-01 |
Lipids and compositions for the delivery of therapeutics Grant 9,186,325 - Manoharan , et al. November 17, 2 | 2015-11-17 |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom Grant 9,156,873 - Prakash , et al. October 13, 2 | 2015-10-13 |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation Grant 9,150,605 - Allerson , et al. October 6, 2 | 2015-10-06 |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation Grant 9,150,606 - Allerson , et al. October 6, 2 | 2015-10-06 |
Biodegradable Lipids For The Delivery Of Active Agents App 20150273068 - MAIER; Martin ;   et al. | 2015-10-01 |
Novel Lipids And Compositions For The Delivery Of Therapeutics App 20150265708 - Manoharan; Muthiah ;   et al. | 2015-09-24 |
Methods and compositions for prevention or treatment of RSV infection Grant 9,127,277 - Vaishnaw , et al. September 8, 2 | 2015-09-08 |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF App 20150247143 - Fitzgerald; Kevin ;   et al. | 2015-09-03 |
Treatment Of Neurological Disorders App 20150224213 - SAH; Dinah W.Y. ;   et al. | 2015-08-13 |
2' and 5' modified monomers and oligonucleotides Grant 9,102,938 - Rajeev , et al. August 11, 2 | 2015-08-11 |
Nucleic Acid Chemical Modifications App 20150210733 - MANOHARAN; Muthiah ;   et al. | 2015-07-30 |
Chemical Modifications Of Monomers And Oligonucleotides With Cycloaddition App 20150203847 - MANOHARAN; Muthiah ;   et al. | 2015-07-23 |
Di-aliphatic Substituted Pegylated Lipids App 20150203446 - Manoharan; Muthiah ;   et al. | 2015-07-23 |
Carbohydrate Conjugated Rna Agents And Process For Their Preparation App 20150196655 - Nair; Jayaprakash K. ;   et al. | 2015-07-16 |
MODIFIED RNAi AGENTS App 20150197746 - Rajeev; Kallanthottathil G. ;   et al. | 2015-07-16 |
Ligand-conjugated Monomers App 20150191726 - MANOHARAN; Muthiah ;   et al. | 2015-07-09 |
Lipid Compositions App 20150190515 - Manoharan; Muthiah ;   et al. | 2015-07-09 |
Biodegradable lipids for the delivery of active agents Grant 9,061,063 - Maier , et al. June 23, 2 | 2015-06-23 |
Lipid Formulations App 20150166465 - Chen; Jianxin ;   et al. | 2015-06-18 |
Process for triphosphate oligonucleotide synthesis Grant 9,035,041 - Zlatev , et al. May 19, 2 | 2015-05-19 |
Carbohydrate Conjugates as Delivery Agents for Oligonucleotides App 20150119444 - MANOHARAN; Muthiah ;   et al. | 2015-04-30 |
Carbohydrate Conjugates as Delivery Agents for Oligonucleotides App 20150119445 - MANOHARAN; Muthiah ;   et al. | 2015-04-30 |
Biodegradable lipids for the delivery of active agents Grant 9,012,498 - Manoharan , et al. April 21, 2 | 2015-04-21 |
Lipids and compositions for the delivery of therapeutics Grant 8,999,351 - Manoharan , et al. April 7, 2 | 2015-04-07 |
Nuclease resistant double-stranded ribonucleic acid Grant 8,993,746 - Vornlocher , et al. March 31, 2 | 2015-03-31 |
5' Phosphate Mimics App 20150080457 - MANOHARAN; Muthiah ;   et al. | 2015-03-19 |
iRNA AGENTS WITH BIOCLEAVABLE TETHERS App 20150073133 - MANOHARAN; Muthiah ;   et al. | 2015-03-12 |
Nucleic acid chemical modifications Grant 8,975,389 - Manoharan , et al. March 10, 2 | 2015-03-10 |
Chemical modifications of monomers and oligonucleotides with cycloaddition Grant 8,962,580 - Manoharan , et al. February 24, 2 | 2015-02-24 |
Ligand-conjugated monomers Grant 8,957,223 - Manoharan , et al. February 17, 2 | 2015-02-17 |
Treatment of neurological disorders Grant 8,957,038 - Sah , et al. February 17, 2 | 2015-02-17 |
Carbohydrate Conjugates as Delivery Agents for Oligonucleotides App 20150011615 - MANOHARAN; Muthiah ;   et al. | 2015-01-08 |
RNAi MODULATION OF RSV AND THERAPEUTIC USES THEREOF App 20150011612 - Meyers; Rachel ;   et al. | 2015-01-08 |
iRNA Agents Targeting VEGF App 20150011608 - de Fougerolles; Antonin ;   et al. | 2015-01-08 |
5' phosphate mimics Grant 8,927,513 - Manoharan , et al. January 6, 2 | 2015-01-06 |
Lipid compositions Grant 8,883,202 - Manoharan , et al. November 11, 2 | 2014-11-11 |
Rnai Agents, Compositions And Methods Of Use Thereof For Treating Transthyretin (ttr) Associated Diseases App 20140315835 - Rajeev; Kallanthottathil G. ;   et al. | 2014-10-23 |
MODIDIFED iRNA AGENTS App 20140316124 - MANOHARAN; Muthiah ;   et al. | 2014-10-23 |
iRNA agents with biocleavable tethers Grant 8,865,677 - Manoharan , et al. October 21, 2 | 2014-10-21 |
Lipids For The Delivery Of Active Agents App 20140308304 - Manoharan; Muthiah ;   et al. | 2014-10-16 |
Therapeutic Compositions App 20140309411 - MANOHARAN; Muthiah ;   et al. | 2014-10-16 |
RNAi modulation of RSV and therapeutic uses thereof Grant 8,859,750 - Meyers , et al. October 14, 2 | 2014-10-14 |
MODIFIED RNAi AGENTS App 20140288158 - Rajeev; Kallanthottathil G. ;   et al. | 2014-09-25 |
Site Specific Delivery Of Nucleic Acids By Combining Targeting Ligands With Endosomolytic Components App 20140256785 - Manoharan; Muthiah ;   et al. | 2014-09-11 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 8,828,956 - Manoharan , et al. September 9, 2 | 2014-09-09 |
Therapeutic compositions Grant 8,809,516 - Manoharan , et al. August 19, 2 | 2014-08-19 |
Lipid formulation Grant 8,802,644 - Chen , et al. August 12, 2 | 2014-08-12 |
Modified iRNA agents Grant 8,796,436 - Manoharan , et al. August 5, 2 | 2014-08-05 |
Pegylated Lipids And Their Use For Drug Delivery App 20140200257 - Rajeev; Kallanthottathil G ;   et al. | 2014-07-17 |
Targeting Lipids App 20140179761 - Manoharan; Muthiah ;   et al. | 2014-06-26 |
Therapeutic compositions Grant 8,754,201 - Manoharan , et al. June 17, 2 | 2014-06-17 |
Lipids and compositions for the delivery of therapeutics Grant 8,722,082 - Manoharan , et al. May 13, 2 | 2014-05-13 |
Lipid Containing Formulations App 20140121393 - Manoharan; Muthiah ;   et al. | 2014-05-01 |
Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes App 20140113957 - Bettencourt; Brian ;   et al. | 2014-04-24 |
Compositions And Methods For Enhancing Production Of A Biological Product App 20140099666 - Rossomando; Anthony ;   et al. | 2014-04-10 |
Compositions and methods for non-parenteral delivery of oligonucleotides Grant 8,691,785 - Teng , et al. April 8, 2 | 2014-04-08 |
Chemically Modified Oligonucleotides For Use In Modulating Micro Rna And Uses Thereof App 20140073684 - Stoffel; Markus ;   et al. | 2014-03-13 |
Folate Conjugates App 20140045919 - Manoharan; Muthiah ;   et al. | 2014-02-13 |
Lipid containing formulations Grant 8,642,076 - Manoharan , et al. February 4, 2 | 2014-02-04 |
Cell-based Bioprocessing App 20140004565 - Rossomando; Anthony ;   et al. | 2014-01-02 |
Compositions For Nucleic Acid Delivery App 20130338210 - Manoharan; Muthiah ;   et al. | 2013-12-19 |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation Grant 8,604,183 - Allerson , et al. December 10, 2 | 2013-12-10 |
5'-end Derivatives App 20130323836 - Manoharan; Muthiah ;   et al. | 2013-12-05 |
Methods And Compositions For Delivery Of Active Agents App 20130323269 - Manoharan; Muthiah ;   et al. | 2013-12-05 |
MODIFIED iRNA AGENTS App 20130317080 - Rajeev; Kallanthottathil G. ;   et al. | 2013-11-28 |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components Grant 8,575,123 - Manoharan , et al. November 5, 2 | 2013-11-05 |
iRNA AGENTS WITH BIOCLEAVABLE TETHERS App 20130281685 - MANOHARAN; Muthiah ;   et al. | 2013-10-24 |
Compositions And Methods For Non-parenteral Delivery Of Oligonucleotides App 20130274309 - Teng; Ching-Leou ;   et al. | 2013-10-17 |
Methods And Compositions For Treating Neurological Disease App 20130261166 - Manoharan; Muthiah ;   et al. | 2013-10-03 |
Conformationally Restricted Dinucleotide Monomers And Oligonucleotides App 20130260460 - Lackey; Jeremy ;   et al. | 2013-10-03 |
Supports for oligomer synthesis Grant 8,541,599 - Ravikumar , et al. September 24, 2 | 2013-09-24 |
Chemically modified oligonucleotides for use in modulation micro RNA and uses thereof Grant 8,541,385 - Stoffel , et al. September 24, 2 | 2013-09-24 |
Multifunctional Copolymers For Nucleic Acid Delivery App 20130236968 - Manoharan; Muthiah ;   et al. | 2013-09-12 |
MODIFIED iRNA AGENTS App 20130211063 - MANOHARAN; Muthiah ;   et al. | 2013-08-15 |
Folate conjugates Grant 8,507,455 - Manoharan , et al. August 13, 2 | 2013-08-13 |
Modified iRNA agents Grant 8,507,661 - Manoharan , et al. August 13, 2 | 2013-08-13 |
2' And 5' Modified Monomers And Oligonucleotides App 20130203836 - Rajeev; Kallanthottathil G. ;   et al. | 2013-08-08 |
Methods And Compositions For Delivery Of Active Agents App 20130202652 - Manoharan; Muthiah ;   et al. | 2013-08-08 |
Biodegradable Lipids For The Delivery Of Active Agents App 20130195920 - MAIER; Martin ;   et al. | 2013-08-01 |
ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND App 20130196434 - MAIER; Martin ;   et al. | 2013-08-01 |
Ligand-conjugated Monomers App 20130184328 - MANOHARAN; Muthiah ;   et al. | 2013-07-18 |
Carbohydrate Conjugates As Delivery Agents For Oligonucleotides App 20130178512 - MANOHARAN; Muthiah ;   et al. | 2013-07-11 |
Methods And Compositions For Prevention Or Treatment Of RSV Infection App 20130165499 - Vaishnaw; Akshay ;   et al. | 2013-06-27 |
Cell-based Methods And Reagents App 20130164329 - Rossomando; Anthony ;   et al. | 2013-06-27 |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety Grant 8,470,988 - Manoharan , et al. June 25, 2 | 2013-06-25 |
Lipid Formulated Single Stranded Rna App 20130156845 - Manoharan; Muthiah ;   et al. | 2013-06-20 |
Nuclease Resistant Double-stranded Ribonucleic Acid App 20130150570 - VORNLOCHER; Hans-Peter ;   et al. | 2013-06-13 |
Therapeutic Compositions App 20130144048 - MANOHARAN; Muthiah ;   et al. | 2013-06-06 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 8,450,467 - Manoharan , et al. May 28, 2 | 2013-05-28 |
Methods And Compositions For Delivery Of Active Agents App 20130129785 - Manoharan; Muthiah ;   et al. | 2013-05-23 |
Oligonucleotides Comprising Acyclic And Abasic Nucleosides And Analogs App 20130130378 - Manoharan; Muthiah ;   et al. | 2013-05-23 |
Therapeutic compositions Grant 8,445,665 - Manoharan , et al. May 21, 2 | 2013-05-21 |
Compositions And Methods For Inhibiting Expression Of Mylip/idol Gene App 20130123332 - Bettencourt; Brian ;   et al. | 2013-05-16 |
Modified 5' Diphosphate Nucleosides And Oligomeric Compounds Prepared Therefrom App 20130109850 - Prakash; Thazha P. ;   et al. | 2013-05-02 |
Process for desilylation of oligonucleotides Grant 8,431,693 - Manoharan , et al. April 30, 2 | 2013-04-30 |
iRNA agents with biocleavable tethers Grant 8,426,377 - Manoharan , et al. April 23, 2 | 2013-04-23 |
Therapeutic compositions Grant 8,420,799 - Manoharan April 16, 2 | 2013-04-16 |
Methods and compositions for prevention or treatment of RSV infection Grant 8,410,073 - Vaishnaw , et al. April 2, 2 | 2013-04-02 |
Ligand-conjugated monomers Grant 8,404,862 - Manoharan , et al. March 26, 2 | 2013-03-26 |
Monomers And Oligonucleotides Comprising Cycloaddition Adduct(s) App 20130053334 - Manoharan; Muthiah ;   et al. | 2013-02-28 |
Compositions and methods for non-parenteral delivery of oligonucleotides Grant 8,377,897 - Teng , et al. February 19, 2 | 2013-02-19 |
Modified iRNA agents Grant 8,344,125 - Manoharan , et al. January 1, 2 | 2013-01-01 |
Nuclease resistant double-stranded ribonucleic acid Grant 8,334,373 - Vornlocher , et al. December 18, 2 | 2012-12-18 |
Compositions and methods for delivering RNAI using lipoproteins Grant 8,324,366 - Akinc , et al. December 4, 2 | 2012-12-04 |
iRNA agents targeting VEGF Grant 8,293,719 - De Fougerolles , et al. October 23, 2 | 2012-10-23 |
Lipid formulation Grant 8,158,601 - Chen , et al. April 17, 2 | 2012-04-17 |
RNAi modulation of RSV and therapeutic uses thereof Grant 8,158,773 - Myers , et al. April 17, 2 | 2012-04-17 |
Supports for oligomer synthesis Grant 8,153,725 - Ravikumar , et al. April 10, 2 | 2012-04-10 |
Therapeutic compositions Grant 8,110,674 - Manoharan , et al. February 7, 2 | 2012-02-07 |
Carbohydrate conjugates as delivery agents for oligonucleotides Grant 8,106,022 - Manoharan , et al. January 31, 2 | 2012-01-31 |
Processes and reagents for desilylation of oligonucleotides Grant 8,063,198 - Manoharan , et al. November 22, 2 | 2011-11-22 |
Processes and reagents for sulfurization of oligonucleotides Grant 8,058,448 - Manoharan , et al. November 15, 2 | 2011-11-15 |
IRNA agents targeting CCR5 expressing cells and uses thereof Grant 8,034,921 - Manoharan , et al. October 11, 2 | 2011-10-11 |
Lipid containing formulations Grant 8,034,376 - Manoharan , et al. October 11, 2 | 2011-10-11 |
Chemically modified oligonucleotides Grant 8,017,763 - Manoharan , et al. September 13, 2 | 2011-09-13 |
Modified iRNA agents Grant 8,017,762 - Manoharan , et al. September 13, 2 | 2011-09-13 |
Oligonucleotides comprising a non-phosphate backbone linkage Grant 8,013,136 - Manoharan , et al. September 6, 2 | 2011-09-06 |
iRNA agents targeting VEGF Grant 7,947,659 - de Fougerolles , et al. May 24, 2 | 2011-05-24 |
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