U.S. patent number 4,921,694 [Application Number 07/197,949] was granted by the patent office on 1990-05-01 for deodorizing and antimicrobial composition for use in cosmetic or topical formulations.
This patent grant is currently assigned to Beiersdorf Aktiengesellschaft. Invention is credited to Ulrich Eigener, Walter Engel, Udo Hoppe, Wolfgang Pape, Gerhard Sauermann.
United States Patent |
4,921,694 |
Hoppe , et al. |
May 1, 1990 |
Deodorizing and antimicrobial composition for use in cosmetic or
topical formulations
Abstract
The invention relates to a deodorizing and antimicrobial
composition for use in cosmetic or topical formulations which
contains one or more 3,7,11-trimethyl-2,6,10-dodecatrien-1-ols, a
phenyl hydroxyalkyl ether with not more than 3 C atoms in the alkyl
radical and glycerol monolaurate.
Inventors: |
Hoppe; Udo (Hamburg,
DE), Eigener; Ulrich (Hamburg, DE),
Sauermann; Gerhard (Wiemersdorf, DE), Engel;
Walter (Pinneberg, DE), Pape; Wolfgang (Hamburg,
DE) |
Assignee: |
Beiersdorf Aktiengesellschaft
(Hamburg, DE)
|
Family
ID: |
25856894 |
Appl.
No.: |
07/197,949 |
Filed: |
May 24, 1988 |
Foreign Application Priority Data
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|
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Jun 24, 1987 [DE] |
|
|
3720831 |
Nov 27, 1987 [DE] |
|
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3740186 |
|
Current U.S.
Class: |
424/65; 424/47;
510/101; 510/389; 510/463; 510/500; 510/505; 510/506; 424/DIG.5;
510/133 |
Current CPC
Class: |
A61Q
15/00 (20130101); A61K 8/375 (20130101); A61Q
5/00 (20130101); A61K 8/33 (20130101); A61K
8/342 (20130101); A61Q 17/005 (20130101); A61K
8/34 (20130101); Y10S 424/05 (20130101) |
Current International
Class: |
A61K
8/34 (20060101); A61K 8/33 (20060101); A61K
8/37 (20060101); A61K 8/30 (20060101); A61Q
15/00 (20060101); A61Q 5/00 (20060101); A61Q
17/00 (20060101); A61K 007/32 (); A61K 007/46 ();
A61K 007/50 (); A61K 009/12 () |
Field of
Search: |
;424/65 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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1642057 |
|
Apr 1971 |
|
DE |
|
2728921 |
|
Jan 1979 |
|
DE |
|
3315058 |
|
Jun 1985 |
|
DE |
|
1155789 |
|
Jun 1969 |
|
GB |
|
Other References
"Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik und Agrenzende
Gebiete", vol. 9, 1981, p. 439..
|
Primary Examiner: Ore; Dale R.
Attorney, Agent or Firm: Sprung Horn Kramer & Woods
Claims
We claim:
1. A synergistic deodorizing and antibacterial composition
consisting essentially of, based on the total amount of the
composition of
(a) 32-36% by weight of at least one
3,7,11-trimethyl-2,6,10-dodecatrien-1-ol,
(b) 51-55% by weight of a phenoxyethanol, and
(c) 9-15% by weight of glycerol monolaurate.
2. A composition according to claim 1, consisting essentially
of
(a) 34% by weight of at least one
3,7,11-trimethyl-2,6,10-dodecatrien-1-ol,
(b) 53% by weight of phenoxyethanol, and
(c) 13% by weight of glycerol monolaurate.
3. A deodorizing cosmetic composition comprising a cosmetic base
and an effective amount of a composition according to claim 1.
4. A deodorizing cosmetic composition comprising a cosmetic base
and 0.05 to 5% by weight of a composition according to claim 1.
5. A method of stabilizing a topical or cosmetic composition
against decomposition by microorganisms which comprises
incorporating therein a composition according to claim 1.
6. The method according to claim 5, wherein the composition is
incorporated in the topical or cosmetic composition in from about
0.5 to 8% by weight.
Description
The invention relates to a deodorizing and antimicrobial
composition for use in cosmetic or topical formulations, in
particular deodorizing cosmetic agents.
Deodorizing cosmetic agents are used in particular to suppress
unpleasant body odour which forms by the action of certain skin
bacteria under the influence of heat and moisture on the initially
largely odourless apocrine perspiration as a result of the
formation of highly odiferous decomposition products.
As well as molecules which absorb odours, two main classes of
products are currently known for combating bad odours resulting
from perspiration.
On the one hand, antiperspirants are known which are based on
products which suppress or greatly inhibit the formation of
perspiration, such as astringents based on aluminium salts and in
particular based on aluminium hydroxychloride. The formation of bad
odours can be suppressed with these agents by suppressing their
immediate cause, that is to say the development of perspiration by
the epidermis (compare German Offenlegungsschrift 2,137,926). In
contrast to these antiperspirants, cosmetic agents with a
deodorizing action are a class of agents which although they have
only a weak effect, if any, on the volume of perspiration, because
of their bactericidal action they destroy the bacteria which lead
to decomposition of the perspiration. These include agents with a
content of antimicrobial substances. Amongst the compounds with
such properties, there have been disclosed, for example, phenol
derivatives with and without halogen substituents, organic mercury
compounds, quaternary ammonium compounds, such as Cequartyl.RTM.,
or certain ion exchangers or metal chelates of 1,3-diketones and
amino acid derivatives with a disinfecting action.
Phenyl hydroxyalkyl ethers, in particular the compound known by the
name phenoxyethanol, have furthermore been used as preservatives on
the basis of their bactericidal and fungicidal actions on a number
of microorganisms. Phenoxyethanol is active above all in an acid
and neutral medium, and also in an alkaline medium, and is
completely non-toxic. It already provides adequate protection in
low concentrations. Because of its neutral taste, it rapidly found
acceptance in the pharmaceutical and cosmetic industries.
Nevertheless, its action is directed chiefly only towards
Gram-negative bacteria.
From the chemical point of view, phenoxyethanol ##STR1## empirical
formula: C.sub.8 H.sub.10 O.sub.2 molecular weight: 138.17
is largely inert when used. It is a colourless, slightly viscous
liquid with a weak, pleasant smell and an astringent taste, and is
miscible with acetone, ethyl alcohol and glycerol, and soluble in
water (1:45) and fats, for example olive oil and groundnut oil
(1:50).
However, the solubility of phenoxyethanol in water is low and is
not sufficient for some preservative purposes.
Phenoxyethanol, which is adequately described in the literature,
has been detected in nature in tropical fruits, in Cichorium
endivia and in green tea (Camellia sinesis). It has a mild,
rose-like fragrance and is also used as a fixative for perfume
compositions.
It is also known from British Patent Specification 1,155,789 that
certain phenyl ethers can be used as antibacterial agents in
cleansing compositions for the skin. Substituted phenyl ethers are
also used as antibacterial agents (compare Offenlegungsschrift
1,642,057).
In a further development of the principle described above, attempts
have therefore been made additionally to use the antimicrobial
properties of certain odiferous substances, essential oils or other
perfume constituents and to employ these as antimicrobial and
deodorizing active compounds in deodorizing perfume compositions.
German Offenlegungsschrift 2,728,921 and German Offenlegungsschrift
3,315,058 describe the natural substance farnesol
(2-trans-6-trans-3,7,11-trimethyldodeca-2,5,10-trien-1-ol) and its
3 synthetic isomers as such an antimicrobially active substance
which greatly inhibits the growth of odour-forming bacteria on the
skin without greatly changing the entire bacterial flora of the
skin. A disadvantage here is, however, that these compounds must be
employed in considerably higher concentrations when used as a
deodorizing antimicrobial active compound than in customary perfume
compositions, in order to achieve the desired deodorizing
effect.
Thus, for example, for complete inhibition of growth of the
Gram-positive bacteria Staphylococcus aureus and Staphylococcus
epidermidis and for substantial inhibition of Corynebacterium
spec., a concentration of 0.3% by weight of farnesol, based on the
cosmetic composition, is required. The content of farnesol in
odiferous compositions and in deodorizing products is 0.2 to
0.5%.
Farnesol ##STR2## 3,7,11-trimethyldodeca-2,5,10-trienol empirical
formula: C.sub.15 H.sub.26 O
molecular weight: 222.36
is an acyclic primary sesquiterpene alcohol, the natural occurrence
of which has been adequately documented in the literature. Thus, it
is found in Lemon-grass oil, palm-arosa oil, citronella oil,
tuberose flower oil, sandalwood oil, linden flower oil, and in many
other natural substances.
It is a colourless liquid with a typical odour and is clearly
soluble in 3 parts of ethyl alcohol (70%).
Glycerol monolaurate, known by the trade name Lauricidin.RTM., is
also to be regarded as a germicide suitable for cosmetic agents. It
is dispersible in water, soluble in alcohol, fats and paraffin oil,
and miscible with acetone.
Glycerol monolaurate ##STR3## Empirical formula: C.sub.15 H.sub.30
O.sub.4 Molecular weight: 274.41
Glycerol monolaurate has been detected in nature at least as a
metabolism product in the digestion of edible fats. Various
monoglycerides are therefore common as additives in the foodstuffs
industry. Glycerol monolaurate itself is used as a pharmaceutical
ointment base, as a coemulsifier for emulsions, and as a
consistency-imparting component for the most diverse cosmetic
agents, such as shampoo, bath additives, creams or lotions.
These two classes of agents described, however, are not completely
satisfactory, because, on the one hand, the astringent agents or
antiperspirants suppress the natural phenomenon of perspiration and
moreover have an adverse effect on the epidermis, and, on the other
hand, some of the bactericidal agents have the disadvantage that
they completely destroy the microbial flora of the skin and
accordingly substantially disturb the biological equilibrium of the
epidermis.
Furthermore, the majority of these agents have a slightly phenolic
odour. For this reason, there have been continuing efforts to
prepare cosmetic agents which have a very good deodorizing action
and a neutral odour and are free from side effects.
Deodorants which dispense with the traditional active compounds
listed have indeed recently become known. For example, attempts
have been made to solve the deodorant problem exclusively via the
perfume. The body odour components are thereby said to be
neutralized in the form of a fragrance complex of the perfume such
that the disadvantageous body odour is masked for some time.
However, the action of these deodorizing cosmetic agents is
inadequate for the requirements of practice in respect of action
potency (masking of odour) and duration of action.
The antibacterial properties of certain odiferous substances,
essential oils or other perfume constituents are furthermore used
individually or as a mixture by manufacturing deodorizing perfume
compositions as such. Products of this type have a deodorizing
effect over a relatively long period of time both via the fragrance
and via the antibacterial action.
Finally, there should also be mentioned a group of substances which
prevent, via enzyme inhibition, unpleasantly smelling decomposition
products from forming from the contents of perspiration, residues
of horny skin and grease of the skin surface.
However, even if the risk of skin irritation is not caused to the
same degree when deodorants are used as when antiperspirants are
used, continuous use of deodorants also sometimes causes
intolerances, photosensitivity and toxic side effects of varying
intensity.
A frequent disadvantage of such deodorizing active compounds is
that not only are the bacteria responsible for the body odour
prevented from growing or destroyed, but moreover other bacteria of
the bacterial skin flora are destroyed. Such deodorizing active
compounds thus undesirably have a considerably more potent action
than would be necessary to avoid body odour.
The following conditions are therefore linked with a satisfactory
deodorant:
(1) preservation of the natural biology of the skin
(2) fragrance neutrality
(3) effectiveness only in respect of deodorization, that is to say
only avoidance of and/or elimination of body odour
(4) avoidance of the formation of resistant strains of bacteria
(5) avoidance of the so-called accumulation effect
(6) innocuousness in the event of overdose or other use not as
specified
(7) good cosmetic use and performance
(8) easy handling (for example as a liquid) and universal
applicability in the most diverse cosmetic and external
formulations
(9) excellent skin and mucous membrane tolerability
(10) use of non-polluting substances
(11) return to natural systems or substances which occur in nature
with status (GRAS, RFM, and the like), and
(12) buffer capacity.
The object of the invention was thus to provide a deodorizing and
antimicrobial composition based on starting substances which occur
in nature or are close to nature, such as, for example, essential
oils or fragrances, which effectively deodorizes with the maximum
possible preservation of the natural biology of the skin, can be
used universally in the most diverse deodorizing cosmetic agents
and thereby requires smaller use quantities than provided by the
previous prior art.
It has been found and the achievement of this object is that a
composition of one or more
3,7,11-trimethyl-2,6,10-dodecatrien-1-ols, a phenyl hydroxyalkyl
ether with not more than 3 C atoms in the alkyl radical and
glycerol monolaurate meets the above requirements.
The invention thus relates to a deodorizing and antimicrobial
composition for use in cosmetic or topical formulations,
characterized in that it contains, based on the total amount of the
formulation,
(a) 15-45, preferably 32-36, % by weight of one or more
3,7,11-trimethyl-2,6,10-dodecatrien-1-ols,
(b) 30-70, preferably 51-55, % by weight of a phenylhydroxyalkyl
ether with not more than 3 C atoms in the alkyl radical, and
(c) 5-25, preferably 9-15, % by weight of glycerol monolaurate,
the amounts being chosen so that the sum of a), b) and c) gives
100%.
The various 3,7,11-trimethyl-2,6,10-dodecatrien-1-ols, that is to
say the natural substance farnesol and its geometric isomers, can
thereby be used individually or in the form of any desired
mixture.
The phenyl hydroxyalkyl ethers with not more than 3 C atoms in the
alkyl radical which are used in the composition according to the
invention are preferably those in which the hydroxyl group is in
position 2 on the alkyl radical.
The use of phenoxyethanol (ethylene glycol monophenyl ether) is
particularly preferred. The ethylene glycol monophenyl ethers are
used in the deodorizing antimicrobial composition according to the
invention in amounts of 30 to 70% by weight, preferably 51 to 55%
by weight, individually or as a mixture.
Although certain antimicrobial properties are also known for
ethylene glycol monophenyl ether (U.S. Pat. No. 2,451,149) and
glycerol monolaurate, the composition according to the invention
has proved surprisingly and unpredictably to be significantly more
effective than was to be expected for the sum of the individual
components.
In microbial studies, a synergistic action of the composition
according to the invention has been detected for several relevant
germs in that the active amount of the composition according to the
invention contained smaller amounts of the 3 components than was
calculated on the basis of the minimum inhibitory concentrations.
Details in this respect are shown in Table 1. As described in
detail in Example 1, the synergistic action was confirmed with the
aid of the so-called Toxi-Chromo-test.
The deodorizing and antimicrobial composition according to the
invention is thus also sufficiently effective at lower use
quantities, compared with the individual components, when used in
topical or cosmetic formulations.
A deodorizing effect can also in part be detected for compositions
of the 3 components which lie outside the compositions claimed in
claim 1. However, such compositions outside the ranges claimed
prove to be unsuitable in practice, because the components can then
no longer be mixed without problems and individual components tend
to form separate phases, which leads to difficulties during
incorporation into topical or cosmetic formulations. This
particularly applies to high contents of glycerol monolaurate.
In contrast, a further advantage of the composition according to
the invention is that it can be used without problems in the
various types of formulations for deodorizing cosmetic agents, such
as roll-on, stick, lotion, spray or solution.
Direct incorporation of the synergistic composition according to
the invention into external compositions and cosmetic agents has
the advantage that homogeneous distribution of the components is
guaranteed and the time-consuming use of the individual components
is thus excluded.
A preferred embodiment of the invention therefore provides
deodorizing cosmetic agents which, in addition to the customary
constituents, contain an effective amount of the composition
according to the invention as the deodorizing active compound.
Deodorizing cosmetic agents which preferably have a content of 0.05
to 5.00% by weight, in particular 0.10 to 0.9% by weight, based on
the total amount of the cosmetic agent of the deodorizing and
antimicrobial composition according to the invention, have
therefore been found to be particularly advantageous in this
embodiment of the invention.
Chemiluminescence measurements on the skin suggest that the good
deodorizing action of the composition according to the invention is
also to be attributed to oxidative reactions induced by the
composition according to the invention, in addition to the
antimicrobial action.
Another advantageous embodiment of the invention is the use of the
deodorizing and antimicrobial composition according to the
invention as an antimicrobial active compound for stabilizing
topical or cosmetic formulations against decomposition by
microorganisms.
The microbiological studies carried out (contact growth index
according to Heiss) were performed with the bacteria species
Staphylococcus aureus ATCC 6538 P, Staphylococcus epidermidis ATCC
12228, E. coli ATCC 8739, Pseudomonas aeruginosa ATCC 9027 and
Propionibacterium acnes ATCC 6917. In each case, concentrations of
0.1, 0.3 and 1.0% of the compounds glycerol monolaurate (G),
farnesol (F) and phenoxyethanol (P) were thereby brought together
individually and as a mixture with a suspension of the test
organisms (10.sup.8 -10.sup.9 colony-forming units (CFU)/ml). The
investigation was carried out in the customary manner, in that
leaves of filter paper with an area of 23.8 cm.sup.2 were each
charged with 0.4 g of in each case a 0.1, 0.3 and 1.0% strength
solution of the compounds (F), (G) and (P) and mixtures thereof.
After drying of the solutions applied, the leaves of filter-paper
were embedded in the nutrient agar in Petri dishes, the surface
being covered with a thin nutrient agar layer. The plate was then
inoculated with the test bacteria (compare Table 1).
The growth-inhibiting action by the test substances or mixtures
thereof was evaluated with the aid of numbers 0 to 4, the index 4
indicating no action at all and no growth (total inhibiting action)
being detectable with number 0. The letter D indicates that, in
addition to the absence of growth in the region of the contact area
of the filter leaf, virtually no growth is also to be detected in
the edge region alongside the filter leaf, and an even better
action than with the index 0 is thus present.
A clear antibacterial action against the 3 Gram-positive species of
the 5 species of bacteria tested, which with these 3 species of
bacteria resulted in total inhibition of growth, can thereby be
detected for mixtures 1-7 in test concentrations of 1.0 and
0.3%.
Total to clear inhibition of growth is also detectable in the two
Staphylococci strains at a use concentration of 0.1% of mixtures
1-7, whilst only slight inhibition by the mixtures 2, 3, 4 and 7
and no inhibition of growth by mixtures 1, 5 and 6 is detectable in
Propionibact. acnes at this concentration.
This is surprising, since farnesol by itself is less active against
the two Staphylococci when used in a concentration of 0.1% than,
for example, mixtures 3, 5, 6 and 7, which contain only 15-34% of
this compound. Glycerol monolaurate, which has a comparable action
to the mixtures mentioned, is contained in these mixtures, however,
in amounts of only 10-25%. Phenoxyethanol shows an action neither
on Staph. aureus nor on Staph. epidermidis.
The pronounced action of the mixtures on Propionibact. acnes is
also surprising, since farnesol and phenoxyethanol show virtually
no action against this test germ as individual substances and
glycerol monolaurate is used in the mixtures in an amount of only
5-25%. Precisely this activity is of the greatest importance, since
this group of bacteria in particular chiefly causes odour formation
in perspiration.
TABLE 1
__________________________________________________________________________
Contact growth index (CGI) of glycerol monolaurate (G), farnesol
(F) and phenoxyethanol (P) and mixtures thereof Concen- Staph.
Contact growth index Test substance tration Staph. epider-
Propionibact. Ps. or mixture used % Use aureus midis acnes
aeruginosa E. coli
__________________________________________________________________________
Glycerol monolaurate 1.0 0.4 g/ D D 0 4 4 0.3 23,8 cm.sup.2 D D 0 4
4 0.1 0 0 2 4 4 Farnesol 1.0 0.4 g/ 0 0 3 4 4 0.3 23,8 cm.sup.2 0 0
4 4 4 0.1 1 2 4 4 4 Phenoxyethanol 1.0 0.4 g/ 4 4 4 4 4 0.3 23,8
cm.sup.2 4 4 4 4 4 0.1 4 4 4 4 4 Mixture 1 1.0 0.4 g/ 0 0 D 4 4 (G
= 5% F = 45% P = 50%) 0.3 23,8 cm.sup.2 0 0 0 4 4 0.1 1 1 4 4 4
Mixture 2 1.0 0.4 g/ D D 0 4 4 (G = 10% F = 35% P = 55%) 0.3 23,8
cm.sup.2 0 0 0 4 4 0.1 0 1 3 4 4 Mixture 3 1.0 0.4 g/ D D D 4 4 (G
= 10% F = 30% P = 60%) 0.3 23,8 cm.sup.2 0 0 D 4 4 0.1 0 0 3 4 4
Mixture 4 1.0 0.4 g/ D 0 D 4 4 (G = 10% F = 20% P = 70%) 0.3 23,8
cm.sup.2 0 0 D 4 4 0.1 1 1 3 4 4 Mixture 5 1.0 0.4 g/ D D D 4 4 (G
= 13% F = 34% P = 53%) 0.3 23,8 cm.sup.2 0 0 D 4 4 0.1 0 0 4 4 4
Mixture 6 1.0 0.4 g/ D D D 4 4 (G = 15% F = 15% P = 70%) 0.3 23,8
cm.sup.2 0 0 D 4 4 0.1 0 0 4 4 4 Mixture 7 1.0 0.4 g/ D D D 4 4 (G
= 25% F = 25% P = 50%) 0.3 23,8 cm.sup.2 0 D D 4 4 0.1 0 0 2 4 4
__________________________________________________________________________
EXAMPLE 1
The following mixture was brought together in a dissolving kettle
with stirring equipment and was stirred at room temperature until a
homogeneous solution had formed:
3,7,11-trimethyl-2,6,10-dodecatrien-1-ol (isomer mixture of 4
isomers, farnesol No. 2/027040 from Dragoco, Holzminden): 34 PW
phenoxyethanol: 53 PW
glycerol monolaurate: 13 PW
The antimicrobial activity of the abovementioned composition
according to the invention was investigated in comparison with the
individual components with the aid of the Toxi-Chromotest (Orgenics
Ltd., Yavne, Israel). The substances were used as 1% strength
solutions or dispersions in water in dilution series. A solution of
mercury chloride (4 mg/l) served as a control, and sodium lauryl
sulphate (1 g/l) served as the internal standard. The minimum
growth inhibition concentrations shown in rable 2 resulted against
the E. coli mutants used for the test.
TABLE 2 ______________________________________ Minimum Test
substance inhibitory concentrations
______________________________________ mercury chloride 0.05 ppm
glycerol monolaurate 9.8 ppm
3,7,11-trimethyl-2,6,10-dodecatrien-1-ol 156.3 ppm (isomer mixture
of all 4 isomers) phenoxyethanol 10,000.0 ppm composition according
to the invention 39.1 ppm sodium lauryl sulphate 62.5 ppm
______________________________________
Table 3 summarizes the concentrations of the individual components
contained in the composition according to the invention and
indicates the percentage of the minimum inhibitory concentration of
each individual component which the composition according to the
invention contains at the concentration which effects complete
inhibition.
TABLE 3 ______________________________________ Concentration in the
% of the minimum composition inhibitory according concentration to
the invention for of the individual Substance complete inhibition
substance ______________________________________ glycerol
monolaurate 5.1 ppm 51.9% 3,7,11-trimethyl- 2,6,10-dodecatrien-1-ol
13.3 ppm 8.5% phenoxyethanol 20.7 ppm 0.2% total 60.6%
______________________________________
This shows that the active amount of the composition according to
the invention contains all the components in concentrations which
are below the minimum inhibitory concentration of the particular
component. If the percentage concentrations of each component in
the maximum inhibitory concentration are added up, a value which is
clearly below the 100% which would be expected with additive
behaviour of the components is obtained.
The composition according to the invention thus has a synergistic
interaction, that is to say the components mutually intensify each
other in their action.
The deodorizing cosmetic agents described in Examples 2 to 9 were
prepared by the processes known to the expert and customary for the
particular agents. The abbreviation PW denotes parts by weight and
the abbreviation EO stands for ethylene oxide units.
EXAMPLE 2
Roll-on deodorant
Methylcellulose (Viskontran.RTM. HEC 30 000): 0.80 PW
Water: 52.00 PW
Ethoxylated glycerol monococoate 7 EO (Cetiol.RTM. HE): 1.00 PW
Hydrogenated castor oil 40 EO (Cremophor.RTM. RH40): 2.50 PW
Ethanol: 39.20 PW
1,2-Propylene glycol: 3.00 PW
Perfume: 1.00 PW
Composition according to the invention from Example 1: 0.15 PW
0.025% strength colouring solution: 0.35 PW
EXAMPLE 3
Deodorizing stick
1,2-Propylene glycol: 46.00 PW
Stearic acid: 7.00 PW
Ethyl alcohol: 35.10 PW
Water: 10.00 PW
NaOH lozenges: 1.20 PW
Perfume: 0.50 PW
Composition according to the invention from Example 1: 0.20 PW
EXAMPLE 4
Deodorizing lotion (viscous)
Polyethylene glycol(20) oleyl ether (Cremophor.RTM.0): 2.00 PW
Cetylstearyl alcohol: 3.00 PW
Paraffin oil: 5.00 PW
1,2-Propylene glycol: 3.00 PW
Polyvinylpyrrolidone (Luviskol.RTM. K30): 0.50 PW
Composition according to the invention from Example 1: 0.15 PW
Water: 89.90 PW
Perfume: 0.45 PW
EXAMPLE 5
Deodorizing lotion (thin)
Ethoxylated fatty alcohol 6 EO (Cremophor.RTM. A): 1.00 PW
Polyethylene glycol(20) oleyl ether (Cremophor.RTM.0): 1.00 PW
Glycerol monostearate: 2.00 PW
Cetyl alcohol: 1.00 PW
Isopropyl myristate: 2.00 Pw
Glycerol: 1.00 PW
Polyvinylpyrrolidone (Luviskol.RTM. K30): 0.50 PW
Composition according to the invention from Example 1: 0.15 PW
Water: 90.90 PW
Perfume: 0.45 PW
EXAMPLE 6
Deodorizing pump spray (not aerosol)
Ethanol: 61.50 PW
Ethoxylated glycerol monococoate 7 EO (Cetiol.RTM. HE): 1.50 PW
Composition according to the invention from Example 1: 0.40 PW
Citric acid: 0.02 PW
Water: 36.18 PW
EXAMPLE 7
Deodorizing body spray (aerosol)
Ethanol: 21.35 PW
1,2-Propylene glycol: 3.00 PW
Octyldodecanol (Eutanol.RTM. G): 0.04 PW
Perfume: 0.50 PW
Composition according to the invention from Example 1: 0.10 PW
Isopropyl myristate: 0.01 PW
Propellant gas: 75.00 PW
EXAMPLE 8
Deodorizing intimate washing solution
30% strength cocoamidopropyl-betain (Tego-Betain.RTM. L7): 10.00
PW
Ethoxylated glycerol monolaurate 22 EO (Tagat.RTM. L2): 2.00 PW
Composition according to the invention from Example 1: 0.10 PW
80% strength lactic acid: 0.50 PW
Perfume: 0.08 PW
Water: 87.32 PW
EXAMPLE 9
Deodorizing agent (liquid) against hair odour
Polyethylene glycol 400: 0.20 PW
Ethanol: 37.50 PW
Perfume: 0.10 PW
Composition according to the invention from Example 1: 0.10 PW
Hydrogenated castor oil 40 EO (Cremophor.RTM. RH 40): 0.20 PW
Citric acid: 0.01 PW
Water: 61.89 PW
EXAMPLE 10
______________________________________ Deodorizing soap
______________________________________ Basic soap 80/20 (about 78%
of fatty acid) 96.84 PW Superfatting agent 1.45 PW Dyestuffs 0.01
PW Antioxidant 0.05 PW Perfume 1.07 PW Titanium dioxide 0.19 PW
Composition according to the invention from Example 1 0.39 PW
100.00 PW ______________________________________
* * * * *