U.S. patent number 3,924,700 [Application Number 05/528,093] was granted by the patent office on 1975-12-09 for blood withdrawing device.
This patent grant is currently assigned to Lifeline Instruments, Inc.. Invention is credited to Homer M. Lindsey, Wilbert D. Silva.
United States Patent |
3,924,700 |
Lindsey , et al. |
December 9, 1975 |
Blood withdrawing device
Abstract
A blood withdrawing device for use in measuring blood withdrawn
from a donor includes a frame on which is mounted a weight
responsive device. In one form there is a balance beam fulcrumed on
the frame and carrying a suspended tray for supporting a blood
container having a supply tube under control of a pinch valve on
the frame. The balance beam is continually balanced by a movable
weight on the balance arm, the weight being advanced and retracted
by an electric motor under control of a counter so that when a
predetermined weight of blood is in the container the pinch valve
is automatically actuated to stop the blood flow. During filling of
the container the tray is mechanically agitated so as to intermix
the incoming blood with an anticoagulant in the container. The
agitation or shaking is periodically interrupted as the blood flows
in and is terminated shortly before the final weighing, then
reinitiated upon completion of total draw.
Inventors: |
Lindsey; Homer M. (Carmichael,
CA), Silva; Wilbert D. (Cupertino, CA) |
Assignee: |
Lifeline Instruments, Inc.
(Sacramento, CA)
|
Family
ID: |
24104238 |
Appl.
No.: |
05/528,093 |
Filed: |
November 29, 1974 |
Current U.S.
Class: |
177/118;
128/DIG.13; 177/214; 604/245; 604/903 |
Current CPC
Class: |
A61M
1/0245 (20130101); A61B 5/15003 (20130101); A61B
5/153 (20130101); A61B 5/150221 (20130101); A61B
5/150366 (20130101); G01G 13/2906 (20130101); Y10S
604/903 (20130101); Y10S 128/13 (20130101) |
Current International
Class: |
A61B
5/15 (20060101); A61M 1/02 (20060101); G01G
13/29 (20060101); G01G 13/00 (20060101); G01G
013/02 (); G01G 007/00 (); A61M 001/00 () |
Field of
Search: |
;177/118,245,212,214
;128/276,DIG.13 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Miller, Jr.; George H.
Attorney, Agent or Firm: Lothrop & West
Claims
What is claimed is:
1. A blood withdrawing device comprising:
a. a frame;
b. a load measuring device on said frame, said load measuring
device being a balance beam;
c. a tray adapted to support a container having a supply tube;
d. means for connecting said tray to transmit a load thereon to
said load measuring device;
e. means on said frame for controlling the flow of blood through
said tube; and,
f. means actuated by said load measuring device for operating said
controlling means including:
a weight mounted for movement along said balance beam,
a motor for moving said weight long said balance beam,
means for effectuating a number of counts in accordance with said
movement,
means for accumulating said counts, and,
means effective at a predetermined number of counts for disabling
said motor.
2. A device as in claim 1 including means for changing said
predetermined number.
3. A device as in claim 1 including means for mounting said tray on
said balance beam for agitation relative thereto, and means on said
frame for agitating said tray relative to said balance beam.
4. A blood withdrawing device comprising:
a. a frame;
b. a load measuring device on said frame, said load measuring
device being an electrically responsive pressure device;
c. a tray adapted to support a container having a supply tube;
d. means for connecting said tray to transmit a load thereon to
said electrically responsive pressure device;
e. means on said frame for controlling the flow of blood through
said supply tube; and,
f. means actuated by said electrically responsive pressure device
for operating said controlling means.
5. A device as in claim 4 in which said electrically responsive
pressure device includes a weight sensor conditioned by said load
on said tray, said weight sensor being capable of converting said
load into an electrical current analog; means for converting said
electrical current analog into equivalent counting pulses; means
for accumulating said counts; a solenoid actuated pinch valve
connected to said supply tube; and means effective at a
predetermined number of counts to close said pinch valve.
6. A blood withdrawing device comprising:
a. a frame;
b. a load measuring device on said frame;
c. a tray adapted to support a container having a supply tube;
d. means for connecting said tray to transmit a load thereon to
said load measuring device;
e. means on said frame for controlling the flow of blood through
said supply tube;
f. means actuated by said load measuring device for operating said
controlling means;
g. means for mounting said tray on said load measuring device for
agitation relative thereto;
h. means on said frame for agitating said tray relative to said
load measuring device; and
i. means for interrupting the operation of said agitating means at
predetermined intervals to provide readings of said load in static
condition.
7. A device as in claim 6 in which said interrupting means is
operable during the loading of said tray and at termination of
blood flow.
8. A device as in claim 7 including means actuated by said load
measuring device for operating said controlling means.
Description
In the withdrawal of blood from a donor, particularly a human
donor, it is highly advisable, and is sometimes required, that the
quantity of blood withdrawn not exceed a particular value. The
value is often based on the weight of the donor and while it may
not exceed a set quantity, it is often desired to vary the setting
in order not to exceed the limit yet to acquire blood up to the set
limit. It is also often advisable to utilize an anticoagulant with
the blood just withdrawn so that during the withdrawal process and
thereafter the blood is kept without any substantial coagulation.
It is also advisable to make the withdrawal process as nearly
automatic and free of possible human errors as may be and to afford
an easy and effective withdrawal process.
To these ends it is an object of the invention to provide a blood
withdrawal device that can easily be utilized in the process of
blood withdrawal and can accurately and efficiently be worked by
personnel who may not be highly skilled.
Another object of the invention is to provide a blood withdrawal
device that measures the withdrawn blood quite accurately by
weight, and volume.
Another object of the invention is to provide a blood withdrawal
device in which the withdrawn blood is maintained in an optimum
condition during withdrawal.
Another object of the invention is to provide a blood withdrawal
device having the desired attributes, yet which can be embodied and
maintained in quite a simple, direct manner.
Another object of the invention is to provide a blood withdrawal
device that is flexible in its operation so that varying parameters
can easily be set and maintained.
Another object of the invention is in general to provide an
improved blood withdrawing device.
Other objects, together with the foregoing, are attained in the
embodiments of the invention described in the accompanying
description and illustrated in the accompanying drawings, in
which:
FIG. 1 is a diagram showing the logical or functional layout of one
form of blood withdrawing device pursuant to the invention;
FIG. 2 is an elevation of one form of blood withdrawing device with
a large portion of the casing broken away to show the interior
construction;
FIG. 3 is a cross-section, the plane of which is indicated by the
line 3--3 of FIG. 2;
FIG. 4 is a view similar to FIG. 2 but showing a modified form of
blood withdrawing device; and
FIG. 5 is a diagram similar to FIG. 1 but disclosing the
arrangement of the modified form of device.
In one arrangement there is provided, as particularly shown in FIG.
2, a frame 6 partly in the form of a housing 7 designed to enclose
and support various of the attendant mechanisms on feet 8 resting
on any suitable supporting surface 9, such as a table or stand.
To receive the blood withdrawn from the donor, there is a container
11, usually a flexible bag, which is provided with a supply tube 12
leading to the customary hypodermic needle and passing through a
pinch valve 13, when open permitting free fluid flow but when
closed inhibiting flow through the tube 12 into the container 11.
The valve 13 is suitably mounted on the frame 6 so as to be readily
accessible to an operator for introducing the tube into the valve
and for withdrawal of the tube therefrom.
The container 11 is placed upon a supporting tray 16 movably
mounted on the frame 6. The tray is especially contoured to accept
and confine the container 11 and to permit easy placement of and
removal of the container. The tray is provided with a special
mounting in connection with a mechanism sensitive to the weight of
the container and its contents. While blood quantity can be dealt
with either in terms of volume (in milliliters) or in terms of
weight (in grams, and usually in a range from zero to a thousand
grams or so), we prefer to calibrate all measurements herein in
terms of volume, bearing in mind, however, that it is blood weight
which is being directly measured.
For this purpose the frame 6 journals an aligned pair of rotatable
stub shafts 17, also termed fulcrum or fulcrum shafts, serving as
the central mounting for a balance beam, generally designated 18.
Included in this arrangement and secured to the pivot shafts 17 is
a pair of lower links 19 which move in unison with the shafts 17.
The lower links 19 form part of a parallelogram linkage also
including a pair of upper links 20 fulcrumed at one end by pins 21
on the main frame 6. At the other end, the lower and upper links
are connected by pivots 22 and 23 to a pair of intervening links
24. A cross bar 25 is secured to the beam 18 and also connnects the
ends of the links 19 adjacent the stub shafts 17. Thus, the balance
beam 18 and the links move in unison. The rocking movement of the
balance beam 18 about the axis of the fulcrum shafts 17 and of the
pairs of links 19 and 20 is productive of a nearly vertical motion
of the pair of intervening links 24.
The tray 16 is pivoted on the pivot pins 23 at its opposite ends,
thereby enabling the tray to swing laterally about the axis of the
pins 23. Also, the tray can move virtually vertically up and down
as the weight of the tray varies. The vertical motion of the tray
16 is transmitted to the links 19 and the cross bar 25 and causes
corresponding rocking movement of the balance beam 18 about the
axis of the stub pivot shafts 17.
It is important that blood supplied to the container 11 through the
tube 12 be maintained in appropriate condition. This is effectuated
by providing the container 11 initially with a supply of an
anticoagulant. To insure that the anticoagulant and the entering
blood are thoroughly intermixed and are maintained so, the
suspended tray 16 is agitated by swinging or oscillation generally
about the axis of the pins 23 as a center. For that reason on the
frame 6 there is mounted an electric drive motor 26 having a crank
pin 27 rotated thereby and connected through a pitman 28 to a pivot
pin 29 positioned in parallel linkage relationship to the pivot
pins 22 and 23. When the motor 26 is energized the tray 16 is
rocked side-to-side about the axis of the pins 23. This motion or
agitation intermixes and comingles the anticoagulant and the blood
so as to maintain the blood in proper condition.
In accordance with the arrangement the balance beam 18 is rocked
about the fulcrum 17 as the weight on the tray 16 decreases and
increases. To maintain the balance beam close to its central,
balanced condition, there is provided thereon a screw shaft 31
journalled at both ends in extensions of the balance beam and
having gearing 32 connecting the screw shaft to a motor 33 mounted
on an L-shaped bracket 35 secured to the base of the housing 7.
Engaging the screw shaft 31 is a dependent weight 34. When the
motor 33 is properly energized, its rotation is transmitted through
the gearing 32 correspondingly to rotate the shaft 31. This moves
the weight 34 toward and away from the fulcrum shaft 17 in a
corresponding fashion. If the weight 34 is appropriately positioned
at a sufficient distance from the fulcrum, the weight of the
container 11 or of the container and its contents is exactly
balanced.
Since there is a slight relative angular movement between the two
gears of the gearing 32 as the balance beam moves, the periphery of
the upper gear 30 on the shaft 31 is somewhat rounded, as appears
most clearly in FIG. 2, to maintain engagement with the lower gear
40 driven by the motor 33 despite any slight rocking movement of
the shaft 31 and gear 30. Meshing of the two gears 30 and 40 occurs
at a point coincident with the axis of the fulcrum shaft 17.
In order to make sure that balance occurs, an appropriate mechanism
is provided. The balance beam 18 has an extension 36 with an
optical aperture 37 therein. In a balanced condition of the beam 18
the aperture 37 is in exact alignment with an optical scanning
device 38 having a source and receptor of light. When the beam is
out of position, a characteristic reflection causes a correction;
and when the beam 18 is in position, the light is transmitted but
not reflected to the structure 38, so no correcting impulse is
supplied thereby. Stated differently, when the beam 18 is out of
position because it is too heavy and the aperture 37 is lowered,
then the mechanism 38 is energized to cause the motor 33 to restore
the balance condition by properly moving the weight 34. A similar
but reverse correction occurs when the beam is out of position
because it is too light.
In addition, the extent of rotation of the shaft 31 and,
correspondingly, the radial position of the weight 34 from the axis
17 is indicated by the location of a disc 41 fixed on the end of
the shaft 31. The disc 41 has spaced apertures and intervening
solid reflectors effective upon an optical device 42 similar to the
arrangement with the device 38. The structure is such that the disc
41, being provided with a predetermined number of especially spaced
apertures, gives a series of indications to the device 42
representative of discrete, rotary positions of the shaft 31. In
this way, as will appear from a discussion of the logic diagram,
the momentary actual weight on the tray 16 is indicated and
compensated for. When a suitable tray weight is attained, the
mechanism for maintaining a substantially equal balance comes to an
end condition. Under those circumstances the valve 13 is actuated
to shut off further blood flow. The operator can then remove the
so-indicated or measured or weighed quantity of blood by removing
the container and can replace the container 11 with another, empty
one for a repetition of the cycle.
In more detail, as shown particularly in FIG. 1, the arrangement is
at least logically, somewhat more elaborate. Within the casing 7
and available from the surface thereof, there are decimal set
wheels 51, 52 and 53, or thumbwheels. These can be arranged
initially by the operator for a predetermined quantity, in three
order terms, of blood to be acquired (e.g., 761 grams, about 720
milliliters). The settable wheels 51, 52 and 53 are effective to
set a standard in a count comparator 54 as a base to compare with
the blood input.
It is to be noted, incidentially, that although the operation of
the balance beam mechanism is based upon blood weight, the wheels
51, 52 and 53 are calibrated in terms of volume, viz. milliliters
(ml.), since most operators are more familiar with volume
measurements.
Having introduced into the machine the measure of the desired
amount of blood to be acquired, the operator then observes a first
ready light 56 on the casing surface. When illuminated, this light
indicates that the machine is clear or free and ready for use with
the balance weight 34 in start position.
The operator then depresses a start switch 57. That action sends an
impulse to a balance drive motor control logic unit 58 which
immediately returns a signal illuminating the start switch 57 to
show that the mechanism is in proper condition to proceed. Since
successive containers 11 may vary in weight, the logic unit 58
first sends an impulse to the balance drive motor 33 and moves the
weight 34 to balance the empty container and to set a starting
point for blood weighing. When this is done, a second ready light
59 is illuminated and a "flow on" switch 60 is enabled. When the
switch 60 is actuated by the operator, a signal goes to a flow
pinch-off logic unit 61 which sends a return signal to illuminate
the switch 60. The signal to the unit 61 operates a flow pinch-off
solenoid 71. This opens the pinch valve 13 to permit blood flow
into the container 11. Also, the logic 58 continues the signal to
the balance drive motor 33. Drive power is derived from a power
supply 62 connected to the usual source through a manually
controlled power switch 63 and itself supplying power through
suitable leads to all power users in the mechanism. The balance
drive motor 33 is thus enabled to advance and retract the weight 34
so as to maintain very nearly an exact balance with the changing,
usually steadily increasing, weight on the tray 16. At any time
blood flow can be stopped by pressing a "flow off" switch 64. This
simply closes the valve 13 by deenergizing the solenoid controlled
by the unit 71. Flow can be resumed by pressing the switch 60.
At the time the balance logic 58 is energized, there is also
energized an interlace unit 66 which normally is effective to pass
a control signal to the agitation drive motor 26 to energize that
motor and so agitate or oscillate the tray 16.
In passing through the interlace logic unit 66, the control for the
agitation drive motor may not be but preferably is subject to
periodic interruption. It is believed that the agitation need not
be continuous but can appropriately be interrupted at intervals to
improve the accuracy of weighing. The agitation may be periodically
interrupted at set intervals and resumed thereafter. This agitation
is usually interrupted to provide a clear reading of the weight
mechanism. That is to say, the optical balance sensor 38 which
controls the logic element 58 to advance or reverse the motor 33 is
slightly more accurate in between operations of the drive motor 26.
For example, the first five seconds of an interlace cycle is quiet
to permit blood weighing. The next fifteen seconds are for
agitation. The final five seconds are without agitation so the
blood may become quiet. The twenty-five second cycle is repeated
indefinitely until a set period just before final weighing.
The described operation continues with respect to the balance until
such time as the weight position responsive device 42 has arrived
at a certain point or number of counts. This point is achieved a
selected or predetermined number of milligrams of weight before the
final value as set into the comparator 54. This function is
particularly accomplished by a look ahead buffer unit 67 deriving
its impulses from the interlace timing logic unit 66.
This arrangement operates fundamentally on the output of the
optical count encoder 42 responsive to the position of the weight
34 and in discrete increments responding to the advancement of the
weight along the balance beam. Each time the impulse device 41
energizes the encoder 42 the count is entered into a counter 68
which affords a count in a decimal mode. The counts are not only
entered into the counter 68 but are also relayed into a "draw"
digital display 69 so that the supervisor or user can at any time
assess the progress of the blood withdrawal. The counts are
accumulated in the counter 68 and are also effective upon the look
ahead buffer 67.
The look ahead buffer 67 subtracts a predetermined number of counts
from the total number of counts manually set into the comparator
54. The buffer 67 transmits to the count comparator 54 the actual
number of counts. When this equals the set-in value less the
arbitrary number of accounts, the comparator 54 does several
things. For one, it sends an impulse to the interlace timing logic
66 and interrupts the operation of the agitation drive motor 26.
Thus, in the final phase of blood withdrawal there is no longer any
oscillation or agitation of the tray and the container, and the
mechanism is quiet for accurate final weighing. In addition, an
impulse goes to the balance drive motor logic 58 so that in a
predetermined number of further pulses the balance drive motor 33
is stopped. Equally important, an impulse to the flow pinch-off
logic 61 occurs after the correct number of counts and an impulse
goes through a normally closed load switch to the flow pinch-off
solenoid control 71. This immediately causes the tube 12 to be
clamped and no further blood to enter the container 11.
Since the predetermined amount of blood has then come into the
container 11 and the cycle to that extent is completed, the count
comparator impulse to the balance drive motor control logic 58
reverses the balance drive motor 33 and retracts the weight 34 to
an initial position. In such position the returned weight actuates
a limit switch 72 which shuts off the motor 33 with the balance in
home position, ready for the next cycle; and it also energizes the
ready light 56 indicating that the machine is then ready for
another cycle. The ready light 56, bing illuminated, again enables
the start switch 57 so that the next cycle can be manually started
at any time.
As a precaution and a safeguard there is also provided a reset
switch 74 which can be manually actuated at any time to stop the
operation of the mechanism by stopping the balance drive motor
control logic unit 58, by interrupting the operation of the
interlace timing logic unit 66 and by actuating the pinch-off logic
unit 61 to energize the solenoid so that the tube 12 is clamped.
The reset switch 74 is for terminating a draw for any reason,
emergency or otherwise, prior to reaching full draw. By depressing
the reset switch 74, the machine is reset to zero (ready for a new
cycle) by activating the motor 33 in the reverse direction until
the weight 34 contacts the limit switch 72 and stops.
In this fashion there is provided a means for automatically
controlling the amount of blood withdrawn from a donor, for
automatically stopping the flow of blood at the predetermined
point, for agitating the withdrawn blood with an anticoagulant
during the operation, for stopping the agitation during critical or
final weighting and for affording a variable quantity of withdrawn
blood for regulating operation of the machine. As previously
indicated, all display elements, such as the draw digital display
69, as well as the thumbwheels 51, 52 and 53 are calibrated in
terms of blood volume (ml). In like manner, all controls, switches,
labels and even the balance mechanism 18 are calibrated in terms of
milliliters (1 ml=1.057 gm).
In most instances the weight measurement is done by the balance
weight mechanism shown in FIG. 2 and 3. But this can also be
accomplished by a variant means, as shown in FIGS. 4 and 5. For the
most part the arrangement of these figures is identical with that
shown in FIGS. 1, 2 and 3 except for mechanism peculiar to the
operation of the balance arm mechanism. In this instance there are
provided manually presettable register wheels 81, 82 and 83 into
which can be initially set the weight in milliliters of blood to be
withdrawn. These in turn introduce their set values into a count
comparator 84 comparable to the comparator 54. The mechanism is
started by the manual actuation of a start switch 86 which controls
an auto zero buffer 87 having several functions. One of the
functions is for the buffer 87 to condition an analog digital
converter 88 to be receptive to analog signals from a weight sensor
89 in the form, usually, of a load cell incorporating its own
bridge electronics.
The weight sensor is conditioned by the actual weight on the tray
and converts such weight into an analog in electrical current
impressed upon the converter 88 which puts out equivalent pulses or
counts. The auto zero buffer 87 has another output which is
effective upon an interlace timing logic unit 91 comparable to the
element 66. When energized the unit 91 is effective to enable an
agitation drive motor 92 comparable to the motor 26 so that the
tray is appropriately agitated or oscillated. The energized
converter 88 produces output signals to a "draw" digital display
93. The display element 93 is comparable to the display element 69
and shows to the user, in volumetric terms, the amount of blood
withdrawn up to the time of reading.
The converter 88 likewise sends pulses to a look ahead buffer 94
comparable to the look ahead buffer 67. This may automatically add
a predetermined number, say 50, digits to the weight generated
output of the converter 88. The artificially augmented value is
introduced into the comparator 84.
In the comparator 84 when the artificially increased value is
received a pulse is sent to two destinations. One is into the
interlace timing logic 91 to interrupt the agitation drive motor 92
a set, short interval before the blood withdrawal has been
completed. The other portion of the impulse from the comparator 84
goes into a flow pinch-off logic element 96 comparable to the
element 61. This is effective when energized, upon receipt of a
second, final load pulse from the comparator, through a normally
closed load switch to actuate a flow pinch-off solenoid 97
effective upon the pinch valve 13, just as before, and so to stop
the withdrawal of blood.
In the present arrangement there is also provided a flow on switch
98 comparable to the switch 60 in FIG. 1 which can be energized to
actuate the logic 96 to open the pinch-off solenoid 97. Similarly,
there is a flow off switch 99, like the switch 64, effective when
actuated through the pinch-off logic 96 to close the pinch-off
valve 13 through its solenoid control 97.
In this way the flow can be started and stopped at any intermediate
part of the cycle, if the operator so chooses.
In this arrangement, as well, the mechanism is effective to measure
an amount of blood as it is being withdrawn, keeping a very close
indication thereof, and agitating the container for the blood in
order to maintain its mixture with an anticoagulant, and finally
stopping the agitation shortly before the end of the withdrawal so
that the weighing mechanism is not interfered with during the final
part of the withdrawal and can accurately stop the withdrawal at
the indicated amount by operation of the pinch valve. During the
operation there is a display of the amount of blood momentarily
available in the container.
Also, the start switch 86 in energizing part of the mechanism
causes the automatic zero buffer 87 first to take the tare weight
of the container and then to zero the weight mechanism in order
that the blood withdrawn will have a net weight value and so that
the weight of the container will not adversely affect the measured
and indicated weight of blood withdrawn.
* * * * *