U.S. patent number 3,923,058 [Application Number 05/484,104] was granted by the patent office on 1975-12-02 for multi-chamber syringe.
This patent grant is currently assigned to The Kendall Company. Invention is credited to Charles Z. Weingarten.
United States Patent |
3,923,058 |
Weingarten |
* December 2, 1975 |
Multi-chamber syringe
Abstract
A syringe has a floating barrier seal located at approximately
the middle of the syringe chamber, thereby forming (at least) two
different chambers on opposite sides of the barrier to provide
separate storage space for (at least) two different medicines. A
hypodermic needle projects inwardly into the adjacent one of the
chambers, far enough to pierce the floating barrier after the first
medicine has been dispensed. The needle passes through the barrier
to dispense the second medicine on the other side of the barrier.
At this time, the barrier seals the first medicine away from the
needle so that it cannot mix with or contaminate the second
medicine.
Inventors: |
Weingarten; Charles Z.
(Wilmette, IL) |
Assignee: |
The Kendall Company (Walpole,
MA)
|
[*] Notice: |
The portion of the term of this patent
subsequent to July 29, 1992 has been disclaimed. |
Family
ID: |
26944433 |
Appl.
No.: |
05/484,104 |
Filed: |
June 28, 1974 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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255099 |
May 19, 1972 |
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Current U.S.
Class: |
604/191;
604/203 |
Current CPC
Class: |
A61M
5/3129 (20130101); A61M 5/284 (20130101); A61M
5/19 (20130101); A61M 5/286 (20130101); A61M
2005/1787 (20130101) |
Current International
Class: |
A61M
5/28 (20060101); A61M 5/31 (20060101); A61M
5/19 (20060101); A61M 005/00 () |
Field of
Search: |
;128/218M,218R,218D,218DA,272,215,216,218P,218F,218A,218G |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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1,201,009 |
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Sep 1965 |
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DT |
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6,616,739 |
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May 1967 |
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NL |
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996,168 |
|
Jun 1965 |
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UK |
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1,054,173 |
|
Dec 1953 |
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FR |
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488,003 |
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Dec 1953 |
|
IT |
|
Primary Examiner: Michell; Robert W.
Assistant Examiner: Opitz; Rick
Attorney, Agent or Firm: Sprunger; Powell L.
Parent Case Text
This is a continuation of application Ser. No. 255,099 filed May
19, 1972, and now abandoned.
Claims
I claim:
1. A multi-chamber syringe comprising a cylinder having at least
one floating barrier means therein forming at least two separate
chambers, with each of said chambers containing a liquid, a plunger
received in said cylinder, hollow needle means attached to one end
of said cylinger and having an unbroken cylindrical shell initially
communicating with the chamber intermediate the barrier means and
said one end of the cylinder, said shell projecting into said
cylinder far enough to puncture and seal said barrier around the
periphery of said unbroken cylindrical needle shell to prevent the
liquids in the two chambers from mixing when said barrier nears the
en of its travel as said syringe is emptied responsive to movement
of said plunger, and means associated with said cylinder between
said one end and said barrier means for relieving back pressure on
said barrier after said needle punctures said barrier whereby said
barrier may continue to settle after having been punctured and
whereby said continued settling occurs without introduction of the
contents of one of said chambers into the other of said
chambers.
2. The syringe of claim 1 wherein said floating barrier means
comprises a soft plug having at least one integrally formed
circumferential piston ring and an axial bore closed by a
membrane.
3. The syringe of claim 2 wherein said means for relieving back
pressure comprises an unbroken but weakened wall area near the
bottom of the stroke between said cylinder and said barrier means,
whereby said weakened wall area ruptures under augmented pressure
to so receive said back pressure and evacuate the liquid under the
floating barrier.
4. The structure of claim 1 and a third closed chamber positioned
adjacent said means for relieving said back pressure after said
barrier means is punctured, said means for relieving back pressure
comprising a weakened rupture area in the wall between said chamber
near the end of said barrel travel and said third closed
chamber.
5. A syringe comprising a cylinder, a plunger received in one end
of the cylinder, a floating barrier received in the cylinder
intermediate the plunger and the other end of the cylinder, and a
closed chamber adjacent said cylinder with a wall common to said
cylinder, a needle extending into said cylinder to pierce said
barrier at a predetermined point in the stroke of said plunger, and
a weakened rupture area in said common wall between the end of said
needle inside said cylinder and the point where said needle is
attached to said syringe.
6. A multi-chamber syringe, comprising:
a hollow cylinder for retaining a liquid;
floating barrier means received in the cylinder defining a first
chamber intermediate the barrier means and one end of the cylinder
and a second chamber intermediate the barrier means and the other
end of the cylinder, with both of said chambers containing a
portion of said liquid;
a plunger received in the one cylinder end for pumping liquid out
of the cylinder;
hollow needle means attached to the other cylinder end and
projecting a sufficient distance into said cylinder to puncture and
seal said barrier means without mixing liquid between the first and
second chambers responsive to movement of the plunger into the
cylinder; and
means for diverting and emptying liquid from the second chamber
after a portion of the liquid is ejected from the second chamber
through the needle means.
Description
This invention relates to syringes for giving multimedicine
injections and, more particularly, to syringes which do not allow
two or more medicines to mix prior to their sequential injection
into a patient.
Syringes are used to inject medicine into the body of a human or an
animal. Usually, the injected medication is a single fluid or a
mixture, in which case the syringe has a single compartment and a
single needle. Sometimes, the medication includes two chemicals or
drugs which must be mixed immediately prior to the injection. Here,
the syringe usually has two compartments separated by a barrier
which either ruptures or opens at the time of injection so that the
injected medicine is a single chemical mixture as it passes into
the patient's body.
When it has been necessary to inject two separate and unmixed
chemicals, the customary practice has been to use two separate
syringes. This doubles the cost of preparing and administering the
mixtures for injection, and it doubles the pain by requiring two
punctures of the patient's skin.
A suggested alternative is to provide twin, rigidly interconnected
syringes which does nothing for the cost, but supposedly gives a
single sensation of pain since the two needles are physically too
close together to be perceived as more than a single point of
contact. Aside from the double cost, this twin syringe requires
greater skill on the part of the doctor or nurse administering the
medication.
Accordingly, an object of this invention is to provide a syringe
for administering two medications which are completely separate and
unmixed at the time of injection. Here an object is to provide a
syringe having substantially the same cost as a single medication
syringe. In this connection, an object is to provide a disposable,
double compartment syringe having such a low cost that it may be
filled with two or more medications and prepackaged in a sterile
container by a pharmaceutical company.
Another object of the invention is to reduce the skill level
required to administer a multi-medication injection. Here, an
object is to reduce the patient's pain and psychological suffering
in anticipation of and during the injection.
In keeping with an aspect of this invention, these and other
objects of the invention are accomplished by a syringe having a
floating barrier therein at approximately the middle of the syringe
chamber. Two different chambers are thereby formed on opposite
sides of the floating barrier to separate the two different
medications. A single hypodermic needle projects inwardly into the
bottom one of the chambers far enough to pierce the floating
barrier after substantially all of the first medication has been
dispensed. The needle passes through the barrier to thereafter
dispense the second medication on the other side of the barrier. At
this time, the barrier seals the first medication away from the
needle so that it cannot mix with or contaminate the second
medication.
The nature of a preferred embodiment of the invention may be
understood best from an inspection of the attached drawings
wherein:
FIG. 1 is an exploded view, in perspective, of the inventive
syringe;
FIGS. 2-5 are stop motion views schematically showing how two
medications are separately dispensed so that neither mixes with or
contaminates the other prior to injection; and
FIG. 6 schematically shows a method of evacuating the remainder of
a first medication after it is no longer being injected into a
patient.
The inventive syringe 20 comprises a needle assembly 21, a cylinder
22, a floating barrier seal 23, and a plunger assembly 24. The
needle is separated into first and second parts 26, 27,
respectively. The first part 26 is sharpened and adapted to pierce
the skin of a person or animal receiving the medication. The second
part 27 of the needle projects into the cylinder 22 for a distance
which is adequate to puncture the barrier 23 when it reaches the
bottom of the cylinder. A preferably plastic collar 28 is firmly
attached to the needle 21 at the junction point between the two
parts 26, 27. The collar 28 includes two oppositely disposed ears
29, 30 which cooperate with internal threads in the syringe to
attach the needle thereto.
The cylinder 22 is an elongated hollow tube of uniform
cross-section, terminated at the bottom in an internally threaded
coupler 35. Concentrically positioned inside coupler 35 is a tube
36 having an axial opening therein to receive the needle 27 with a
sufficiently tight seal to preclude leaking. The threads 37 inside
the coupler 35 engage and receive the ears 29, 30 on the collar 28.
Thus, as the assembly 28 is rotated, the two parts 28, 35 come
together with a tight seal.
The upper end of the cylinder 22 has opposing tabs 38, 39 which are
held by the index and middle fingers of the person administering
the injection. The upper end 40 of the cylinder 22 is beveled to
provide a conical entrance for guiding and directing the barrier 23
and plunger 24 members upon entrance into the cylinder. The entire
unit is preferably made from low cost, thin-walled, transparent
plastic material so that the person administering the injection can
watch the operation to be sure that the medications are properly
fed into the patient.
According to the invention, a floating barrier member 23 is
provided for forming two separate chambers in the tube. Preferably,
this barrier is a soft rubber plug which has two longitudinally
displaced piston rings 41, 42 for making a good seal against the
interior wall of the cylinder 22. The bottom 44 of the plug is
somewhat conical to help guide it on its entrance into the cylinder
22. An axial bore 45 almost completely pierces the plug forming the
floating barrier member 23. However, the bottom of the bore 45 does
not quite extend through the bottom of the plug. Therefore, the
bottom of the bore 45 is covered by a thin membrane 46 to prevent
any fluid from passing through the barrier.
The plunger assembly 24 comprises a ram rod 50 having a soft rubber
plug 51 attached to the bottom and a thumb pad 52 attached to the
other end. The plugs 23 and 51 are almost identical, both slide
inside the cylinder 22.
The method of its use is illustrated by the stop motion views of
FIGS. 2-5. Preferably, a pharmaceutical manufacturer loads the
inventive syringe in his laboratory or factory by depositing a
first medicine 54 in the bottom of the cylinder 22. Then, the
barrier 23 is placed in the tube and brought down into contact with
the top of the medicine surface, to eliminate all entrapped air.
One way of doing this is to invert the syringe, allow the entrapped
air to escape through the tube 36, and then to seal the tube.
After the first medicine 54 is loaded into the first compartment, a
second medicine 55 is loaded into the second compartment. Then, the
plunger assembly 24 is brought down into contact with the upper
surface of the second medicine, and all entrapped air is withdrawn.
One way to withdraw the entrapped air is to slip a small tube of
hypodermic needle stock between the soft rubber plug 51 and the
inside surface of the cylinder 22 and to vacuum pump the air from
the upper chamber. The inventive syringe (FIG. 2) is now preloaded
with two completely separated medications 54, 55, held securely
apart, one from the other.
As the injection is given (FIG. 3), only the first medicine passes
out of the chamber 22 and through the needle 26, into the patient.
As the first medicine is exhausted, the floating barrier 23 engages
and is pierced by the upper end 27 of the needle 21. It is easy to
so pierce the floating barrier since only the thin membrane 46 is
present at this point. Thereafter, the needle end 27 is in the bore
45 which provides an unimpeded passage for the medicine in the
upper chamber. The rubber-like material of the floating barrier
surrounds and seals the outside of the needle 27 and prevents any
more of the first medicine 54 from passing through the needle.
At this time (FIG. 4), the second medicine 55 passes through the
needle 27 and into the patient receiving the injection. The second
medicine is not mixed with or contaminated by the first medicine at
any time before or during the injection.
At the bottom of the stroke (FIG. 5), the plug 51 reaches the top
of the barrier 23 or the needle 27, where it terminates the flow of
the medicine through the needle. The medicine is now exhausted, and
the spent syringe is discarded.
It is apparent that the same principle may be extended to an
administration of a larger number of medicines by increasing the
number of floating barriers and, therefore, the number of separate
compartments inside the cylinder 22. The membrane member 46 is thin
enough and the rubber plug 23 is soft enough so that the needle top
27 may penetrate the bore 45 far enough to admit the second
medicine 55 to the needle. However, sometimes the first medicine 54
entrapped under the floating barrier 23 should be evacuated to
relieve pressure and to allow the barrier 23 to settle further into
the cylinder 22. This is especially true if there are two or more
floating barriers. The first barrier must settle to allow the
second barrier to be pierced by the needle 27.
To provide relief from the back pressure of the first medication,
the cylinder 22 is weakened at a point 60 in the entrapped area 61.
An adjacent chamber 62 is positioned to communicate with the
entrapped area 61 when the weakened point 60 ruptures. As the first
medicine 54 is ejected from the cylinder 22, the pressure does not
exceed the rupture strength of the weakened area 60. However, when
the medication 54 flow is blocked by the needle end 27 passing
through the floating barrier, the fluid pressure builds in the
entrapped area 61. Weakened area 60 ruptures under the augmented
pressure, and the entrapped medication flows from area 61 into a
closed and, perhaps, evacuated chamber 62. As the fluid flows from
area 61, the barrier 23 settles further into cylinder 22 in order
to enable the needle end 27 to properly perform its penetration
function. There cannot be a reverse flow since the punctured
membrane 46 of the floating barrier 23 seals itself around the
outside periphery of the needle. Moreover, any pressure
differential is such that the flow will be from the cylinder 22
into the chamber 62.
It should be understood that modifications may be made without
departing from the scope of the invention. Therefore, the appended
claims should be construed to cover all equivalent structures.
* * * * *