U.S. patent number 3,920,995 [Application Number 05/471,636] was granted by the patent office on 1975-11-18 for radioactive material generator.
This patent grant is currently assigned to E. R. Squibb & Sons, Inc.. Invention is credited to Bernard J. Bolter, Gerald A. Bruno, Thomas V. Czaplinski, Robert E. Heyer.
United States Patent |
3,920,995 |
Czaplinski , et al. |
November 18, 1975 |
Radioactive material generator
Abstract
A radioactive material generator includes radioactive material
in a column, which column is connected to inlet and outlet
conduits, the generator being embedded in a lead casing. The inlet
and outlet conduits extend through the casing and are topped by
pierceable closure caps. A fitting, containing means to connect an
eluent supply and an eluate container, is adapted to pierce the
closure caps. The lead casing and the fitting are compatibly
contoured such that they will fit only if properly aligned with
respect to each other.
Inventors: |
Czaplinski; Thomas V. (North
Brunswick, NJ), Bolter; Bernard J. (Trenton, NJ), Heyer;
Robert E. (Hopatcong, NJ), Bruno; Gerald A. (Shrewsbury,
NJ) |
Assignee: |
E. R. Squibb & Sons, Inc.
(Princeton, NJ)
|
Family
ID: |
26999652 |
Appl.
No.: |
05/471,636 |
Filed: |
May 20, 1974 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
|
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357433 |
May 4, 1973 |
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Current U.S.
Class: |
250/432R;
250/493.1; 250/432PD |
Current CPC
Class: |
G21G
4/06 (20130101); G21G 1/0005 (20130101) |
Current International
Class: |
G21G
4/06 (20060101); G21G 4/00 (20060101); G01M
021/24 () |
Field of
Search: |
;250/432,493 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Dixon; Harold A.
Attorney, Agent or Firm: Levinson; Lawrence S. Smith; Merle
J. Archer; John J.
Parent Case Text
This is a continuation-in-part application of Ser. No. 357,433,
filed May 4, 1973, now abandoned.
Claims
What is claimed is:
1. A generator for sterile, elutable radioactive material which
comprises a hollow column containing elutable radioactive material,
said column including inlet and outlet ports which are each in
communication with one end of inlet and outlet conduits
respectively, the other ends of said conduits being terminated by
pierceable closure caps, which caps prevent the inflow of
contaminents through said conduits, said column, inlet and outlet
conduits and caps being embedded in a casing adapted to permit the
caps to be pierced, a fitting adapted to be joined to said casing,
means to properly align said fitting on said casing to effect
joinder therebetween, said fitting including means to pierce said
caps, and said fitting including means in communication with said
piercing means for the cap on said inlet conduit to connect a
container of eluent, said eluent being passable through said inlet
conduit into said column, means in communication with said piercing
means for the cap on said outlet conduit to connect a collecting
container for eluate to said fitting, and means to establish a
pressure differential between said eluent and collecting containers
causing the eluent to flow through said conduits and into said
collecting container.
2. The generator of claim 1 wherein the means to join said casing
and said fitting in proper alignment comprise a boss on said
fitting adapted to be received in an opening in said casing, a
guide segment connected to said boss and a mating segment connected
to said casing, whereby said fitting and said casing can be joined
only when said segments are mated.
3. The generator of claim 1 wherein said casing is formed of
vertically split sections, each section including appropriate
interior depressions to accommodate said conduits and said column
therein.
4. The generator of claim 3 wherein said split sections include
spaced interior ribs and grooves, there being only one position in
which respective grooves and ribs are matable.
5. The generator of claim 1 including needles, depending from each
of said means to connect said container of eluent, and said means
to connect said collecting container, each adapted to pierce the
respective caps, thereby to define a complete fluid flow path
between said eluent and said collecting containers.
6. The generator of claim 1 including means to admit air into said
eluent container upon the evacuation of the eluent therefrom.
7. The generator of claim 1 wherein the means to establish a
pressure differential between said eluent and collecting containers
is an evacuated eluate collecting container.
Description
BACKGROUND OF THE INVENTION
The present invention relates to a radioactive material generator,
and in particular, the combination of such a generator and a
fitting which permits eluent supply means and eluate withdrawal
means to be operatively coupled thereto.
The use of radiosotopes in medicine, for diagnosis and treatment,
is well known and its use is under great expansion. Generally,
isotope solution is eluted from a radioactive material generator
when and as the material is to be utilized. THe reason for this is
that the daughter isotope generally has an extremely short
half-life and must be prepared at the proximate time of use. To
satisfy this requirement, numerous systems have been devised to
enable the physician to assemble the various components of the
generator and then elute the usable solution.
The radioactive generators have traditionally been of the type
shown in U.S. Pat. No. 3,369,121 issued Feb. 13, 1968 and U.S. Pat.
NO. 3,440,423 issued Apr. 22, 1969. As there described, the
generator comprises radioactive material such as a column of
alumina impregnated with Mo.sup.99. The daughter isotope, in this
case Tc.sup.99m, is eluted from the generator by means of a saline
or dilute hydrochloric acid solution. The alumina is suspended in a
plastic housing and naturally there must be means supplied to
introduce the eluent and to withdraw the eluate, i.e., the isotope
solution. In the prior art, these means have comprised pierceable
stoppers through which the fluids are introduced and removed by
means of hypodermic needles. Recent developments include the
provision of inlet and outlet conduits which are similarly sealed
by pierceable stoppers.
In all of the prior art embodiments, cumbersome and complex
protective equipment had to be utilized to protect various
personnel from being exposed to the emission of the generator. The
various protective equipment utilized required the physician to
assemble heavy parts and suspend various bottles, in short, calling
upon him to perform far too many manipulations. The present
invention is directed to a fitting which renders the generator
quite simple to use, eliminates unnecessary manipulations, and at
the same time provides complete protection against radioactive
emissions.
SUMMARY OF THE INVENTION
The generator incorporated in the instant invention comprises a
column of alumina inpregnated with Mo.sup.99. The alumina is
suspended in a cylindrical housing annd the housing is sealed at
both ends. An inlet conduit, for the introduction of the eluting
solution, is provided and connected to the upper portion of the
housing. An outlet conduit, for withdrawing eluate from the
generator, is provided and connected to the lower end of the
housing. Both conduits are sealed by means of pierceable caps.
The housing and conduits are embedded in a wing-shaped, split lead
casing, the casing interface being contoured to conform to the
housing contour and the contours of the conduits. Each section of
the split casing is suitably contoured to accept a portion of the
housing and of each conduit. Additionally, the interface is
composed of alternate ribs and grooves, and may include other
means, such that there is only one position at which the casing
sections can be joined. The casing sections are suitably joined, as
for example, by means of nuts and bolts, snap clasps, or other
suitable means.
The conduit sealing caps may protrude above the top surface of the
casing, above raised platforms which are situate at the top left
and top right corners of the casing, or these conduit sealing caps
or covers may be housed within the lead casing to provide
additional radiation shielding. The interior sidewalls of the
platforms are formed into parallel arcuate sections or other
nonsymmetrical surfaces. This formation constitutes a key-way which
insures proper alignment of the fitting when it is assembled to the
casing.
The fitting incorporated into the instant invention comprises a
lead bar having adjacent the respective ends thereof, holes into
which inserts are received, which inserts accommodate eluent supply
means and eluate withdrawal means. Those holes are positioned such
that they are directly above the sealing caps of the inlet and
outlet conduits upon assemblage of the fitting to the casing. The
eluent supply and eluate withdrawal means are adapted to
accommodate the eluent container and the eluate container,
preferably an evacuated vial which draws the desired solution out
of the generator.
To insure proper assemblage of the fitting and the casing, the
fitting is provided on the undersurface thereof with a plug or boss
having lateral surfaces complementary to the surfaces of the
interior sidewalls of the raised platforms on the top of the
casing. When such interior sidewalls are parallel arcuate sections,
the boss may be of generally circular shape (the diameter being
identical to that of the arc of each interior sidewall of the
platforms) so that the boss mates with one of the sidewalls, and a
guide section, which is adjacent to and of the same arcuate contour
as the other platform sidewall, mates with the other sidewall. The
provision of what is effectively a key and key-way structure
eliminates the possibility that the fitting will be improperly
assembled to the casing.
The eluent supply means and eluate withdrawal means are preferably
incorporated into a unitary molded plastic receptacle holder for
the eluent container and the eluate container. This receptacle
holder also provides the means, including the two double ended
hypodermic needles, for fluid connection between the eluent
container and the inlet conduit and between the eluate container
and outlet conduit through the pierceable closure caps of the
containers and the conduits. The receptacle holder may be connected
to the lead bar of the fitting to form an integrated unit or the
receptacle holder may be provided with a locating or positioning
pin and releasable fasteners so that it may be mounted on the lead
bar in the proper operative position at the time of use.
The above and other aspects of the present invention will be
further amplified as the description continues, and when read in
conjunction with the appended drawings.
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a perspective view of a fitting showing all the structure
on the bottom thereof;
FIG. 2 is a perspective view of a casing showing the structure on
the top thereof;
FIG. 3 is a front elevational view of a fitting, cross-sectioned to
show the needle structure thereof;
FIG. 4 is a perspective view of a generator partially cut-away to
reveal the connection therewith of the outlet conduit;
FIG. 5 is a front elevational view of the casing of FIG. 2 showing
the interior of the split sections of the casing in side by side
relation;
FIG. 6 is a front elevational view of the fitting of FIGS. 1 and 3
assembled to the casing of FIGS. 2 and 5, partially cut-away to
expose the needles piercing the sealing caps;
FIG. 7 is a perspective view of an alternative embodiment of a
portion of a fitting showing a receptacle holder with needle
adapter assembly and the structure on the bottom thereof;
FIG. 8 is a perspective view of an alternative embodiment of a
casing showing the structure on the top thereof;
FIG. 9 is a front elevational view of an alternative embodiment of
a fitting, exploded and partly in cross-section to show the
receptacle holder with needle adapter assembly of FIG. 7 and the
manner of joining the receptacle holder and the lead bar portions
of the fitting; and
FIG. 10 is a front elevational view of the casing of FIG. 8 showing
the interior of the split sections of the casing in side by side
relation.
DETAILED DESCRIPTION
The present invention incorporates a radioactive material generator
10 as illustrated in FIG. 4. That generator is similar in operative
aspects as that shown and described in U.S. Pat. No. 3,369,121 and
3,440,423. The generator 10 comprises the cylindrical housing 12 in
which a chromatographic grade of alumina, impregnated with
Mo.sup.99, is suspended. The generator 10 is milked of its product
solution, containing Tc.sup.99m, by means of an eluent which may be
saline, dilute hydrochloric acid or other suitable solutions. The
system for eluate withdrawal from the generator and for introducing
the eluent will be described in greater detail as the description
continues.
The generator 10 is sealed at its top 14 and bottom 16 by stoppers
17 which are adapted to be pierced by hypodermic needles for the
purpose of loading the generator 10. The radioactive molybdenum
solution can thereby be introduced by pypodermic needle and
connected syringe or other suitable means through the top stopper
17 into contact with the alumina and the excess solution drawn off
by piercing the bottom stopper 17 with a hypodermic needle
connected to a syringe or to a vacuum line. The stoppers 17 are
preferably formed of a gas pervious, pierceable material which is
autoclavable, such as silicone, e.g., methylvinylpolysiloxane. As
noted in U.S. Pat. No. 3,801,818 issued Apr. 2, 1974, such closures
or stoppers are capable of venting gases which may be internally
generated during the autoclaving procedure by which the generator
10 is sterilized.
In most prior art generators in which the top and bottom are closed
by pierceable seals, the eluent is added and the eluate is
withdrawn through such seals. The generator 10 of the instant
invention provides for eluent addition via a conduit 18 and eluate
removal via conduit 20. In this embodiment the conduits are shown
as being separate tubes encapsulated within projections 22, 24
which are unitary with the housing 12. It should be evident that
the conduits 18, 20 may be unitary with the housing 12, the entire
unit being formed of a molded plastic. It is to be noted that the
outer terminal ends of the conduits 18, 20 are sealed by means of
covers or caps 26, 28. The covers 26, 28, according to FIG. 4,
comprise a molded cup 30 having a stem 32, which stem encapsulates
the upper terminus of the conduits 18, 20. The open ends of the
conduits 18, 20 however, are not blocked by cup 30, but are open to
the cup chamber. A pierceable closure 34, fabricated from material
such as silicone or neoprene, is sealingly received in the cup 30,
and is held in place by means of a flexible metallic ring 33 which
is crimped about the cup 30 and the closure 34.
From the structure thus far described, it follows that eluent is
injected into the generator 10 by being passed through the closure
34 into the cup 30, and from there into inlet conduit 18. By
providing a reduced pressure in cover 28, the eluent is sucked
through the generator 10, passing through the alumina bed where it
picks up the Tc.sup.99m, into the lower chamber 38, and into the
lower terminus 40 of the outlet conduit 20. An evacuated container
is advantageously used to provide the reduced pressure in cover 28,
and it draws the fluid out of cup 30 in cover 28. This eluate is
immediately ready to be injected into a patient.
The generator hereinbefore described must be properly shielded
inasmuch as the physician and the patient should not be
unnecessarily exposed to the emissions therefrom. Accordingly, a
lead casing is provided to house the entire generator 10. As shown
in FIGS. 2 and 5, the casing 42 is vertically split into two parts
44, 46. The mating interior surfaces which form the interface of
joinder are suitably contoured to closely accommodate therein the
generator 10 and the conduits 18, 20. To this end, each is provided
with a central depression 48 which accepts the cylindrical housing
in close confinement. Channels 50, 52 are provided for the
acceptance of the conduits 18, 20. The part 44 may be made thicker
than part 46 and will therefore more deeply accommodate the
generator 10 and conduits 18, 20. In this fashion the channels will
be formed in the part 44, there being only slight depressions 54,
56 in the part 46 to complement the channels 50, 52. Depressions 58
are provided in various positions to accommodate the projections
22, 24 and stems 32. The interior surfaces of the parts 44, 46 are
ribbed and grooved to insure that those parts are properly
mated.
As shown in FIG. 2, when the parts 44, 46 are joined the casing 42
resembles a fuselage-like section 60 flanked by wings 62, 64. The
parts 44, 46 may be joined by means of screws (not shown) received
in openings 68, and nuts (not shown) received in countersunk holes
in one of the parts to provide a secure joinder. It is obvious that
other means of joining parts 44 and 46 may be used. The wings 62,
64 are seen to terminate in upper flat surfaces 70, 72, which
surfaces integrate into the fuselage 60. The surfaces 70, 72
respectively step up to platforms 74, 76 which are also flat. It is
important to note the configuration of the respective sidewalls 78,
80 of those steps. Each sidewall is arcuate and they are
essentially parallel. This configuration provides a key-way the
function of which has been described previously and will be more
evident as the description continues. It is to be recognized, that
when the generator 10 is enclosed in casing 42, the covers 26, 28
are situate above the platforms 74, 76 to make them accessible to
the eluent supply and eluate withdrawal equipment illustrated in
FIGS. 1 and 3.
Turning now to FIGS. 1, 3 and 6 the eluent supply and eluate
withdrawal equipment is integrated into a fitting 100. That
fitting's major component is a rectangular lead bar 102 which
includes the holes 104, 106 adjacent the respective ends thereof.
Protruding from the undersurface of the bar 102 is a boss or
disc-like member 108 which can be of unitary construction with that
bar. The disc 108 is of sufficient diameter to generally cover the
entire area between the platforms 74, 76. That disc includes a
guide surface 110 which is of the same contour as the sidewall 78.
It should be evident that the guide surface 110 will mate only with
sidewall 78 and not with sidewall 80. This insures that when the
fitting 100 is assembled to casing 42 they will be properly
aligned.
As shown in FIGS. 1, 3 and 6, a unitary molded plastic receptacle
holder 112 is connected to the upper surface of bar 102 by way of
the skirts 114, 116 which depend into recesses 118, 120 in the bar
sidewalls 122, 124 and are crimped about ribs 126, 128
respectively. The receptacle holder 112 includes a holder 130 for
an eluate container, preferably an evacuated vial. That holder
extends into hole 106 and above the top surface of receptacle
holder 112. The holder 130 is sealed at the top and bottom of the
bar 102 except for the central portion which supports a double
ended hypodermic needle 132. It is through that needle that the
eluate is withdrawn via outlet conduit 20. The receptacle holder
112 also includes an eluent container holder 134 which, like holder
130 extends into the bar 102 and projects thereabove. The holder
134 is also similarly sealed and supports the hypodermic needles
136, 138. Needle 138 is similar to needle 132, it is double ended
and serves to conduct eluent into the generator 10. The needle 136
does not extend below the upper surface of bar 102 and serves only
to provide an inlet for air into an eluent container. The conduit
142 connects needle 136 with the atmosphere through a hydrophobic
filter (not shown). A filter (not shown) may be incorporated at the
lower portion of the holder 130 to remove any particulate matter
that may pass into the needle 132.
In use, the physician assembles the components of the system
illustrated in FIGS. 1 through 6 at the proximate time of usage.
Initially, the generator 10, enclosed in the casing 42, may be
stored in a lead pig for further protection against emission. The
fitting 100 is then assembled to the casing 42 by properly aligning
the disc 108 and pressing on the fitting until the needles 132, 138
pierce the respective closures 26, 28 of the inlet and outlet
conduits 18, 20. An eluent container (not shown) is assembled
upside down on the holder 134, the neck thereof being received
therein; and the needles 136, 138 pierce a sealing diaphragm of
that container. A completed entry path from the eluent container
through needle 138 and inlet conduit 18 is now defined into the
interior of generator 10. An evacuated vial is then similarly
assembled atop the holder 130 as the eluate container, with the
needle 132 piercing its sealing diaphragm. The pressure
differential produced by the evacuated eluate container draws the
eluent through the needle 138, through the closure 34, through
conduit 18 and through the alumina where it picks up the
Tc.sup.99m. Thereafter the eluate is drawn into bottom chamber 38
from which it passes into conduit 20. It is then drawn through
needle 132 and into the eluate container.
An alternative embodiment of the casing and of the fitting are
illustrated in FIGS. 7 through 10.
As shown in FIGS. 8 and 10, the lead casing 242 is very similar to
the embodiment illustrated in FIGS. 2 and 5. The casing 242 is in
two vertical sections 244, 246. The mating interior surfaces of the
sections 244 and 246 which form the interface of joinder are
suitably contoured to closely accommodate therein the generator 10,
the inlet and outlet conduits 18, 20, and the covers or caps 26,
28. For this purpose, each of the sections 244, 246 is provided
with a central depression 248 which accommodates the cylindrical
housing 12 of the generator 10 in close confinement. The depression
248 extends from the top to the bottom of each of the sections 244,
246 to provide in the assembled casing 242 an access opening to
each of the pierceable stoppers 17 at the top 14 and the bottom 16
of the housing 12 of the generator 10 contained within the casing
242. These openings are provided to permit loading of the generator
10 after it has been enclosed within the lead casing 242. Channels
250, 252 are provided for the inlet and outlet conduits 18, 20. The
sections 244, 246 are substantially the same thickness, and
therefore, each provides substantial portions of these channels
250, 252 for the conduits 18, 20. The interior ends 258 of the
channels 250, 252 accommodate the connections (shown in FIG. 4 as
projections 22, 24) of the conduits 18, 20 to the cylindrical
housing 12 of the generator 10. As shown in FIG. 10, channels 250,
252 provide for a housing 12 and conduits 18, 20 which are molded
as a single unit so that no projections (such as 22, 24 of FIG. 4)
are present at the connections of conduits 18, 20 to housing 12.
Depressions 259 are provided to accommodate the covers or caps 26,
28 which seal the outer terminal ends of the conduits 18, 20. In
this embodiment of FIGS. 8 and 10, the covers 26, 28 are within the
lead casing 242 to provide additional radiation shielding. The
depressions 259 extend to the top surfaces of the platforms 274 and
276 of the casing 242 so that when sections 244, 246 are joined an
opening is provided permitting access to the pierceable closures 34
of the covers 26, 28 of inlet and outlet conduits 18, 20. The
interior surfaces of the sections 244, 246 are ribbed and grooved
to insure that the sections 244, 246 are properly mated. In
addition, four locating lugs 261 fit into four depressions 263 to
hold the sections 244, 246 in proper position with respect to each
other.
In FIG. 8, the sections 244, 246 are shown joined to form the
casing 242 which is very similar to the casing 42 of FIG. 2, i.e.,
the casing 242 also resembles a fuselage-like portion 260 flanked
by wing-like portions 262, 264. The sections 244, 246 may be
fastened together by any suitable means providing a secure joinder.
As shown in FIG. 8, the sections 244, 246 are held together by
spring clips 265, which may be formed of any suitable material such
as metal or plastic, in the notches 267 provided in the outside
surface of each of the wing-like portions 262, 264 of sections 244,
246. The top of the casing 242 is formed of three flat surfaces
270, 274 and 276. The surface 270 surrounds the opening, formed by
depression 248 in each of sections 244 and 246, at the top of the
fuselage-like portion 260 and also extends over part of the top of
each of the wing-like portions 262, 264 to the base of sidewalls
278 and 280 of the raised platforms 274 and 276 the top surfaces of
which are flat and coplanar. The surfaces 274 and 276 each surround
an opening formed by the depressions 259 in the sections 244 and
246. The sidewall 278 is formed by three angled vertical surfaces
approximating an arc, and the sidewall 280 is a single vertical
surface lateral to the sections 244, 246. Together these sidewalls
278, 280 form a keyway to cooperate with a key 208 of the fitting
200 to position the fitting 200 correctly on the casing 242 as will
be described more fully later in the description. The platforms 274
and 276 are of sufficient height to enclose the covers 26, 28 of
the generator 10.
FIGS. 7 and 9 illustrate features of an alternative embodiment of a
fitting 200 which provides the means for eluent supply and eluate
withdrawal. In this embodiment of the fitting 200, a lead bar 202
and a separate receptacle holder including needle adapter assembly
212 are joined on top of the casing 242 when the generator 10 is to
be eluted. Lead bar 202 is provided on its underside with a boss or
key 208 which is suitably an integral part of bar 202. The boss 208
has a curved surface 210 and a flat surface 211 at opposite ends to
form a key which will mate with the keyway provided by the
sidewalls 278 and 280 of the casing 242 to insure that the lead bar
202 can be mounted only in one position on the casing 242. The lead
bar 202 may remain in place on the casing 242 to provide additional
radiation shielding. The casing 242 and lead bar 202 are
customarily retained at all times in a lead pig (not shown) having
a cavity contoured to the shape of the casing 242 and lead bar 202
to provide additional radiation shielding. The top of the lead bar
202 is exposed when it is in place in the lead pig so that wells
204 and 206 are accessible to the needle adapter assembly of
receptacle holder 212. The locator hole 213 in lead bar 202 in
cooperation with the locating pin 215 of the receptacle holder 212
requires that assembly may be accomplished in only the correct
position. Each of the wells 204, 206 includes a lug or key 217 on
the inside wall to mate with keyways 219 of the needle shielding
guides or plugs 221 when the receptacle holder 212 is mounted on
the lead bar 202. These lugs 217 also provide means for retaining
radiation shielding plugs (not shown) in the wells 204, 206 when
the generator 10 is not being eluted. A rectangular cut out 223
near each corner of the lead bar 202 provides for the guides 225
which assist in assembling the receptacle holder 212 to the lead
bar 202 and which may include lugs (not shown) to act as releasable
fasteners to a protective plastic cover (not shown) which might be
used over the lead bar 202 and lead pig (not shown). The slot 227
is provided as a means to secure the lead bar 202 to the lead pig
(not shown).
The receptacle holder 212 shown in FIG. 7 and 9 is a unitary molded
plastic holder for an eluent container (not shown) and an eluate
container (not shown). The eluate container is preferably an
evacuated vial and is inserted upside down into holder 230, after
removal of protective cap 231, where double ended hypodermic needle
232 is positioned to pierce the closure of the eluate container.
The needle 232 may include an intermediate filter 319 with
associated lead shielding 320 and spring means 321 to hold it in
place, and the bottom portion of the needle 232 is supported and
centered by needle shielding guide or plug 221 mounted on the
underside of holder 230 and which contains the collapsible needle
shield 229. This needle shield 229 can be drawn down over the
needle 232 to protect it when the receptacle holder 212 is not in
use and is pushed out of the way into plug 221 when the receptacle
holder 212 is mounted on the lead bar 202 and casing 242.
The receptacle holder 212 also includes holder 234 for an eluent
container (not shown) which is inserted in an inverted position,
after the removal of protective cover 235, so that needles 236 and
238 may pierce its closure. The needles 236 and 238 are supported
within the holder 234. Needle 238 is a double ended hypodermic
needle to conduct eluent into generator 10, and it is supported and
centered by guide 221 and protected by needle shield 229 in the
same manner as described above with respect to needle 232. Needle
236 serves to provide an inlet for air into the eluent container by
connecting it to the atmosphere through conduit 242 and a
hydrophobic filter 243.
The alternative embodiment of the fitting illustrated in FIGS. 7
and 9 includes as an optional but preferred feature the filter 319.
This filter 319 is placed in the eluate collection line formed by
conduit 20 and needle 232 and serves to further insure that the
eluate collected from the generator 10 will be sterile and particle
free and thereby suitable for immediate injection into a patient
for diagnostic use. This filter 319 may be any suitable filter but
is preferably a MIllipore filter, i.e., a microporous membrane
filter composed of cellulose esters or similar polymeric materials,
such as described in U.S. Pat. No. 3,386,585, issued June 4, 1968,
or U.S. Pat. No. 3,471,019, issued Oct. 7, 1969, and manufactured
by Millipore Corporation of Bedford, Massachusetts. A particularly
desirable filter is a 0.22 micron Millipore filter in which part of
the filter is hydrophobic. This filter has very good flow
characteristics, and maintains good flow characteristics after the
initial elution, i.e., on subsequent runs after the hydrophilic
portion has already been wetted.
When the generator 10 is to be eluted with the embodiments of the
casing 242 and fitting 200 illustrated in FIGS. 7 through 10, the
technician removes lead plugs (not shown) from the two wells 204,
206 of the bar 202 in position on the casing 242 containing the
generator 10. The locator pin 215 is aligned with the depression
213 and this permits the insertion of the needle shielding plugs
221 with needles 238 and 232 of the receptacle holder 212. The
needles 238 and 232 pass down through the wells 204, 206 and pierce
the covers 26, 28 of the inlet and outlet conduits 18, 20. When the
eluent container and eluate container have been inserted into
holders 234 and 230 to pierce their closures with the needles 236,
238 and 232, the elution will take place when a reduced pressure is
present at the top of needle 232 in the eluate container. This
reduced pressure is preferably obtained by the use of an evacuated
vial as an eluate container. As elution proceeds, eluent is drawn
through needle 238 into and through inlet conduit 18, through the
alumina in generator 10 where it picks up the Tc.sup. 99m, to the
bottom of generator 10 where it passes into and through outlet
conduit 20, through the bottom portion of needle 232, through the
filter 319 which interrupts needle 232, through the balance of
needle 232 and into the eluate container.
At no time is this system rendered vulnerable to the inflow of
contaminents nor does it permit leakage of the emissive fluids. The
system is simple to assemble, there being little room for error in
aligning the parts. All concerned parties are adequately protected
from emission until the preparation is withdrawn for injection.
Many changes may be made in the details of the instant invention,
in the method and materials of fabrication, in the configuration
and assemblage of the constituent elements without departing from
the spirit and scope of the appended claims, which changes are
intended to be embraced therewithin .
* * * * *