U.S. patent number 3,916,892 [Application Number 05/464,835] was granted by the patent office on 1975-11-04 for phlebotomy needle system incorporating means to add anticoagulant and wash liquid.
This patent grant is currently assigned to Haemonetics Corporation. Invention is credited to Allen Latham, Jr..
United States Patent |
3,916,892 |
Latham, Jr. |
November 4, 1975 |
**Please see images for:
( Certificate of Correction ) ** |
Phlebotomy needle system incorporating means to add anticoagulant
and wash liquid
Abstract
A phlebotomy needle system providing means to introduce
anticoagulant into blood immediately after it is discharged from
the needle cannula into a blood transfer tube and to coat the walls
of the tube with a thin film of anticoagulant up until at least
that point where the anticoagulant is thoroughly mixed through the
blood. Means are also provided within the same system for
backflowing a wash solution into the needle.
Inventors: |
Latham, Jr.; Allen (Jamaica
Plain, MA) |
Assignee: |
Haemonetics Corporation
(Natick, MA)
|
Family
ID: |
23845432 |
Appl.
No.: |
05/464,835 |
Filed: |
April 29, 1974 |
Current U.S.
Class: |
604/83; 604/272;
604/903; 604/6.07; 604/269; 604/326 |
Current CPC
Class: |
A61M
1/85 (20210501); A61M 1/3646 (20140204); Y10S
604/903 (20130101) |
Current International
Class: |
A61M
1/00 (20060101); A61M 1/36 (20060101); A61M
001/02 () |
Field of
Search: |
;128/2B,2F,214R,214C,214.2,214.4,221,276-278,347,240-241 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Truluck; Dalton L.
Attorney, Agent or Firm: Lepper; Bessie A.
Claims
I claim:
1. In a phlebotomy needle system suitable for withdrawing blood
from a donor and delivering said blood to a reservoir through a
blood transfer tube, including a needle cannula and hub affixed
thereto and having tubulation means for introducing an
anticoagulant into said blood as it is transferred to said
reservoir, the improvement comprising a socket member removably
connected through a liquid-tight friction fit with said hub, said
socket member comprising a central chamber into which the discharge
end of said cannula extends, supporting means within said socket
member by which the inlet end of said blood-transfer tube is
supported in position to surround said discharge end of said
cannula to define an annular passage therebetween providing
communication between said central chamber and said blood transfer
tube, a first auxiliary transfer tube, and means by which the
discharge end of said first auxiliary transfer tube is supported in
said socket member whereby said first auxiliary tube is in fluid
communication with said annular passage through said central
chamber.
2. A phlebotomy needle system in accordance with claim 1 including
a second auxiliary transfer tube and means by which the discharge
end of said second auxiliary transfer tube is supported in said
socket member whereby said second auxiliary transfer tube is in
fluid communication with said annular passage through said central
chamber.
3. In a phlebotomy needle system including a needle cannula
suitable for withdrawing blood from a donor and having tubulation
means for introducing an anticoagulant into said blood as it is
transferred to a reservoir, the improvement comprising
a. a tapered hub fit over the discharge end of said cannula of said
needle to allow a short length of said discharge end to extend
beyond said hub; and
b. a socket member affixed to said hub through a removable
liquid-tight friction fit and defining therein
1. a central chamber,
2. a central channel opening into said central chamber having
affixed therein a blood-transfer tube defining an internal passage
and being of sufficient depth to permit a portion of said shorth
length of said discharge 2. of said cannula to extend into said
central channel to define with said internal passage of said
blood-transfer tube an annular fluid passage, and
c. a first side channel having affixed therein a first auxiliary
tubing in fluid communication through said central chamber with
said annular fluid passage, whereby when an anticoagulant is
introduced through said first auxiliary tubing it is mixed with
said blood before it encounters any surface beyond said discharge
end of said cannula.
4. A phlebotomy needle system in accordance with claim 3 including
a second side channel having affixed therein a second auxiliary
tubing in fluid communication through said central chamber with
said annular fluid passage, whereby when a wash solution is
introduced through said second auxiliary tubing in the absence of
blood and anticoagulant flow it enters the discharge end of said
cannula by way of said annular passage.
5. A phlebotomy needle system particularly suited for use in a
pheresis procedure, comprising in combination
a. a needle comprising a cannula and a hub which includes a tapered
section, and is affixed to said cannula to allow a short free
length of the discharge end of said cannula to extend beyond said
hub;
b. a primary tubing adapted to transfer blood and two auxiliary
tubings adapted to transfer an anticoagulant and a wash
solution;
c. a socket member removably engaged with said hub, having a
central chamber and holding the ends of said primary and auxiliary
tubings in relation to the discharge end of said cannula whereby
said free length of said cannula extends through said central
chamber into said primary tubing to define an annular passage
providing fluid communication between said central chamber and said
primary tubing and said auxiliary tubings are in fluid
communication with said annular path through said central
chamber.
6. A phlebotomy needle system in accordance with claim 5 wherein
said socket member has seat means for positioning the ends of said
tubings therein.
7. A phlebotomy needle system in accordance with claim 5 wherein
said tubings are bonded to said socket member.
8. A phlebotomy needle system in accordance with claim 5 wherein
said hub makes a liquid-tight, friction fit within said socket
member.
9. A phlebotomy needle system in accordance with claim 5 including
gripper means affixed to said hub.
10. A phlebotomy needle system in accordance with claim 5 wherein
said cannula is a rigid stainless steel tubing.
11. A phlebotomy needle system in accordance with claim 5 wherein
said cannula is a flexible tubing having a rigid lancet extending
therethrough and beyond the inlet and outlet ends of said flexible
tubing.
12. A phlebotomy needle system in accordance with claim 5 including
a source of an anticoagulant connected to one of said auxiliary
tubings and a saline wash solution connected to the other of said
auxiliary tubings and means to control the flow of said
anticoagulant and said wash solution through said tubings.
13. A phlebotomy system in accordance with claim 5 wherein said
primary tubing is connected to a blood reservoir.
14. A phlebotomy system in accordance with claim 13 wherein said
reservoir is a centrifuge rotor.
Description
This invention relates to phlebotomy needles and particularly to
phlebotomy needles systems used in pheresis procedures wherein more
than one unit of blood may be conducted through the needle.
In the pheresis procedure, blood is withdrawn from a donor, the
desired blood component (usually platelets) is separated out from
the blood, and the blood essentially free of the desired component
is returned directly to the donor. This procedure normally permits
the donor to donate many units of certain blood components during
the time normally required for regeneration of one unit of whole
blood. Since, however, a greater quantity of blood must flow in
both directions through the pheresis needle and its associated
tubulations, the possibilities of the blood's clotting within the
needle and tubulations increases. Measures must therefore be taken
to prevent such clotting.
The needle systems presently used in the pheresis procedure are
hooked up with an array of fitments and tubulations such that there
are various discontinuities on the walls of the internal blood
passage between the point of the cannula of the needle and the
junction of the passage with the admission point of an
anticoagulant which is added to the blood. It is well known that
many of the discontinuities in the surface of a passageway for
whole blood which has not been treated with an anticoagulant tend
to initiate a clotting reaction which, over a brief period of time,
will build up a clot of sufficient size to restrict blood flow. It
is common practice to introduce an anticoagulant into the blood
sometime after it leaves the cannula of the needle, a practice
which permits the blood to contact the tubulation surface prior to
the addition of the anticoagulent. This tubulation is joined
through fitments to the cannula; and such fitments and their
associated tubulations (normally referred to as the "harness") of
the presently used pheresis needles are permanently attached to the
needle. This means that if for any reason the needle can not be
used successfully, it is necessary to replace the entire harness
before attempting a fresh venipunctuce. Finally, it is customary in
using the presently available pheresis needles to provide separate
fitments and tubulation (harness) for the admission of a saline
wash solution, an arrangement which complicates the structure and
use of the needle and adds to its cost.
It would therefore be desirable to have a phlebotomy needle system,
and particularly a phelbotomy needle system useable for the
pheresis procedure, which overcomes the disadvantages associated
with the prior art types of needles systems designed for this
purpose.
It is therefore a primary object of this invention to provide a
phlebotomy needle system particularly suitable for pheresis
procedures which essentially eliminates the possibility of clot
formation in the needle, in its fitments and in tubulations
attached thereto. It is an additional object of this invention to
provide a phlebotomy needle system of the character described which
provides for the introduction of the anticoagulant into the blood
at the discharge end of the cannula and also provides for
introducing the anticoagulant as a continuous film on the walls of
the blood passageway so that the blood encounters anticoagulant
before it encounters any wall of the passageway beyond the
discharge end of the cannula.
It is another object of this invention to provide a phlebotomy
needle and harness which permits the disengagement of the needle
from the harness and replacement by another needle while
maintaining aseptic conditions.
Still another primary object of this invention is to provide a
phlebotomy needle system with such fitments and tubulation which
incorporate directly therein means to introduce a saline wash
solution through said needle when blood is not being carried
through the needle.
Other objects of the invention will in part be obvious and will in
part be apparent hereinafter.
In the phlebotomy needle system of this invention, the cannula is
fitted at the discharge end with a tapered hub positioned to allow
a short free length of the cannula to extend beyond the hub. The
hub makes a removable liquid-tight friction fit with one end of a
socket member which has a central chamber. A central channel and
two auxiliary side channels extend through the other end of the hub
into the central chamber. The central channel is sized to permit a
blood-transfer tubing to be inserted therein and bonded to the
socket. When the hub is fitted into the socket the free length of
the cannula extends into the central tubulation and defines with it
an annular fluid passage in fluid communication with the central
chamber in the socket. The two auxiliary side channels have tubings
inserted in them and these tubings are in turn bonded to the socket
member. When an anticoagulant is introduced through the tubing in
one of the auxiliary channels it is caused to flow through the
annular fluid passage to be mixed with the blood immediately as it
is discharged from the cannula and to form a film along the inner
wall of the blood-transfer tubing. Thus no blood without
anticoagulant contacts the tubulation surface. In a similar manner,
when blood flow through the needle is stopped, a saline wash
solution may be introduced through the tubing in the other of the
auxiliary channels to flow through the annular fluid passage and
enter the discharge end of the cannula.
The invention accordingly comprises the features of construction,
combination of elements, and arrangement of parts which will be
exemplified in the construction hereinafter set forth, and the
scope of the invention will be indicated in the claims.
For a fuller understanding of the nature and objects of the
invention, reference should be had to the following detailed
description taken in connection with the accompanying drawings in
which
FIG. 1 is a general view of the needle system of this invention
showing the auxiliary tubings attached to a source of an
anticoagulant and a source of a saline wash solution;
FIG. 2 is a side elevational view of one embodiment of a needle of
the needle system of this invention illustrating the use of a
stainless steel cannula;
FIG. 3 is a cross section of the needle of FIG. 2 taken through
plane 3--3 of FIG. 2;
FIG. 4 is a cross section of another embodiment of a needle of the
needle system of this invention illustrating the use of a flexible
cannula having a rigid lancet;
FIG. 5 is a longitudinal cross section of the socket member of this
invention showing the hub of the needle in fully engaged
position;
FIG. 6 is a longitudinal cross section of the socket member of FIG.
5 taken through plane 6--6 of FIG. 4;
FIG. 7 is a top plan view of the socket member without tubulations;
and
FIG. 8 is a cross section of the socket member of FIG. 5 taken
through plane 8--8 of FIG. 5.
The phlebotomy needle of this invention is illustrated in FIG. 1
with its harness attached to a source of anticoagulant a source of
saline solution and a blood reservoir in the form of a centrifuge
rotor. The needle 10 is comprised of a cannula 11, a hub 12 and a
gripping member 13 affixed to the hub. In FIG. 1 the needle is
shown to be partially withdrawn from its aseptic cover 14 which is
not part of this invention. Hub 12 is engaged with a socket member
16 to which the blood-transfer tubing 17, the anticoagulant tubing
18 and saline solution tubing 19 are affixed. Hub 16 and tubings
17, 18 and 19 make up the harness generally indicated at 20.
Anticoagulant tubing 18 is shown to be connected to an
anticoagulant source 21, and saline solution tubing to a saline
solution source 22. Pinch clamps 23 and 24 are provided to control
the flow of the anticoagulant and saline solution, respectively. In
the system of FIG. 1, the liquids are gravity fed. It is, of
course, within the scope of this invention to use any other means
to cause the anticoagulant and the saline solutions to flow in
their respective tubings and to use means other than pinch clamps
to control their flow. The actual means by which these liquids are
introduced into and pumped through the tubulations is not part of
this invention. The blood transfer tubing is shown to be connected
to a reservoir 25, such as a centrifuge rotor of a system similar
to that shown in U.S. Pat. No. 3,145,713.
Two embodiments of needles suitable for use in the needle system of
this invention are shown in side elevational and cross sectional
views in FIGS. 2-4. In these FIGURES, as well as in all of the
other of the FIGURES, the same reference numerals are used to
identify the same elements of the apparatus.
In the needle embodiment of FIGS. 2 and 3 the cannula 11 is of the
well-known rigid, stainless steel type; while in FIG. 4 it is
formed as a flexible tubing 25 having a bevelled end 26. Such
tubing is generally made from a polytetrafluoroethylene resin.
Since cannula 25 is flexible, it is necessary to give it the
necessary degree of rigidity for venipuncture and this is done by
inserting a solid stainless steel lancet 27 throughout the entire
length of the flexible tubing 25. The end 28 of the lancet which
extends just beyond the inlet end of cannula 25 is configured to
gain ready access to the interior of the vein and provide for the
insertion of flexible cannula 25 into the vein, and the end 29 of
the lancet which extends beyond the discharge end of cannula 25 is
bonded to a needle cap 32 which is configured to fit over hub 12.
Subsequent to making the venipuncture, cap 32 is removed while
pressure is supplied to the vein, thus withdrawing the lancet and
opening the passage in flexible cannula 25. The term "cannula" is
therefore hereinafter used in its broadest sense to designate
either a rigid or flexible tubing member. In FIGS. 5-8, the cannula
11 of FIGS. 2 and 3 is shown as an exemplary cannula.
In either needle embodiment of FIGS. 3 or 4, the hub 12, typically
formed of a haemocompatible molded plastic such as polycarbonate,
is fitted onto the discharge end of the cannula and bonded thereto
by ultrasonic insertion or by a suitable adhesive. Hub 12 has a
tapered section 30, the diameter decreasing toward the discharge
end of cannula 11, and a straight section 31. The gripping member
13 (or 13a in FIG. 4) is attached to straight section 31. A short
length of cannula 11 or 25 extends beyond the tapered section 30 of
the hub. As is known in the art, gripping member 13 or 13a is of a
flat configuration designed to give the doctor or nurse performing
the venipuncture a firm grip on the needle and a means for sensing
needle orientation.
The socket member 16, through which the needle is removably
attached to the harness, is shown in several views in FIGS. 5 - 8.
This socket like the hub 12 is molded of a suitable haemocompatible
synthetic resin material such as a polycarbonate. Socket 16 is
formed to have a needle-engaging section 35, shown in the drawings
to have an external taper with the diameter increasing toward the
discharge end of cannula 11, and a tubulation-engaging section 36
of a generally elliptical configuration as seen in FIGS. 7 and 8.
This external taper in the needle-engaging section 35 is not
essential. Needle-engaging section 35 has a hub-engaging passage 37
having a tapered configuration, the diameter of the internal walls
of the passage decreasing toward the internal opening 38 which
terminates in central chamber 39 within the socket member. The
degree of taper of passage 37 corresponds to that of hub section 30
so that when the needle is affixed to the socket, the surface of
hub section 30 makes a liquid-tight friction fit with the wall of
hub-engaging passage 37 of the socket member.
Tubulation section 36 of the socket member (shown in top plan view
of FIG. 7 and in cross-section in FIG. 8) is configured to accept
and hold blood-transfer tubing 17 axially aligned with cannula 11
and the two auxiliary tubings 18 and 19 for anticoagulant and
saline solution on either side. A central channel 40 defined by
wall 41, which terminates internally in the socket in a lip 42,
serves to receive and hold blood-transfer tubing 17. This tubing is
seated on lip 42 and is bonded to the socket member such as by
solvent bonding around entrance 43 of channel 40. The location of
the lip seat 42 should be such as to position blood-transfer tubing
17 so that the free end of cannula 11 extends into it to define an
annular liquid passageway 44.
Similarly, the socket member has a wall 45, merging into one side
of wall 41, to define channel 46 terminating in a lip 47 to receive
and seat anticoagulant tubing 18 which is bonded at 48 to the
socket. Liquid communication between tubing 18 and central chamber
39 is by way of channel 49. In like manner, the socket member has a
wall 50, merging into the other side of wall 41, to define channel
51 terminating in a lip 52 to receive and seat saline solution
tubing 19 which is bonded at 53 to the socket. Liquid communication
between tubing 19 and central chamber 39 is by way of channel
54.
In some applications of a needle system such as the one of this
invention, it may not be necessary to backwash the needle with
saline solution. Therefore it is within the scope of this invention
to eliminate saline solution tubulation 19, channel 51 in the
socket and channel 54 within chamber 39.
Prior to making the venipuncture, the anticoagulant tubing, socket
member passages, needle cannula and adjacent portions of the blood
tubing are primed with anticoagulant. In operation, as soon as
blood begins to flow in cannula 11, the flow of anticoagulant
through tubing 18 is begun. It will be seen in FIG. 5 that the
anticoagulant (the flow of which is indicated by the dotted arrows
on only one side of passage 44) enters blood-transfer tubing 17
through annular passage 44 by way of channel 49 and central chamber
30. Thus the anticoagulant is available for mixing with the blood
(the flow of which is indicated by the solid arrows) immediately
upon its discharge from cannula 11. This flow pattern of the
anticoagulant, which is, of course, around the entire surface of
cannula 11, also provides a continuous film of anticoagulant around
the entire surface of the inner wall of tubulation 17 up to at
least a point where the anticoagulant is thoroughly mixed with the
blood. This means that the unanticoagulated blood never comes into
contact with any discontinuities in the transfer system which could
give rise to clotting. Hence a free flow of blood is insured
throughout the pheresis procedure.
In the case where the needle of FIG. 4 with a flexible cannula is
used, the socket 16 and harness 20 are not attached to the needle
until after the venipuncture is accomplished. As noted previously
in the description of FIG. 4, after venipuncture is made, the
needle cap 32 is removed and along with it the steel lancet. During
the removal of cap 32 and engagement of the needle with the hub,
pressure is applied to the punctured vein. Once this engagement is
effected the pressure is removed and the anticoagulant is added to
the blood as described.
When the flow of blood and anticoagulant is stopped, the flow of
saline wash solution, if used, is begun through tubing 19. As
indicated by the dash-dot arrows, this saline solution travels
through channel 54, central chamber 39 and annular passage 44 to
enter the discharge end of cannula 11, thus washing the passages
free from blood which could clot. This saline solution also, of
course, contacts the entire surface of the walls defining passage
44, the single arrow being used for clarity in the drawing.
If during venipuncture, the needle fails for one reason or another,
if may be readily disengaged from its friction fit with the socket
and replaced by another needle without the need for replacing the
socket and the tubulation connections as well. By incorporating the
ability to introduce the saline wash solution through the same
connections within the socket member, a material saving in cost of
equipment is realized. Moreover, the entire procedure is simplified
and as a result is made more fail-safe.
It will thus be seen that the objects set forth above, among those
made apparent from the preceding description, are efficiently
attained and, since certain changes may be made in the above
construction without departing from the scope of the invention, it
is intended that all matter contained in the above description or
shown in the accompanying drawings shall be interpreted as
illustrative and not in a limiting sense.
* * * * *