U.S. patent number 3,902,491 [Application Number 05/462,767] was granted by the patent office on 1975-09-02 for syringe usable as container for storage and preservation of injection fluid.
This patent grant is currently assigned to Compagnie Generale de Radiologie. Invention is credited to Pierre Lajus.
United States Patent |
3,902,491 |
Lajus |
September 2, 1975 |
Syringe usable as container for storage and preservation of
injection fluid
Abstract
A syringe which may be used for storage and preservation of
injection fluid includes a hollow cylindrical body which has an
outlet end and an inlet end. A rupturable member is provided at the
outlet end. A flange is provided at the inlet end. A sealing
member, which is desirably a fluid-impermeable membrane, is fixed
to the flange to seal the inlet end. A rod is provided on which a
piston is connected. The piston is positionable, with respect to
the cylindrical body, for entering its interior, rupturing the
sealing member and moving toward its outlet end. As a result, the
injection fluid stored and preserved within the hollow cylinder may
be removed via the outlet end by the piston under the influence of
the rod.
Inventors: |
Lajus; Pierre (Paris,
FR) |
Assignee: |
Compagnie Generale de
Radiologie (FR)
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Family
ID: |
9118614 |
Appl.
No.: |
05/462,767 |
Filed: |
April 22, 1974 |
Foreign Application Priority Data
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Apr 27, 1973 [FR] |
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73.15452 |
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Current U.S.
Class: |
604/221;
206/438 |
Current CPC
Class: |
A61M
5/31513 (20130101); A61M 5/24 (20130101); A61M
2005/3121 (20130101) |
Current International
Class: |
A61M
5/24 (20060101); A61M 5/315 (20060101); A61M
5/31 (20060101); A61M 005/315 (); A61J
001/00 () |
Field of
Search: |
;128/218R,218D,218P,218M,218PA,218A,215,234,235,261,272
;206/365-368,437,438,219-223,498 ;215/257,250 ;222/386 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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1,212,565 |
|
Nov 1970 |
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GB |
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116,726 |
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Jun 1918 |
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GB |
|
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: McGowan; J. C.
Attorney, Agent or Firm: Greigg; Edwin E.
Claims
What is claimed is:
1. A syringe which may be used for storage and preservation of
injection fluid comprising, in combination:
a. a hollow, cylindrical body having an outlet end and an inlet
end;
b. a rupturable member at said outlet end;
c. means defining a sealing surface at said inlet end;
d. a sealing member which is fixed to said sealing surface to seal
said inlet end;
e. rod means; and
f. a piston connected to said rod means and movably positioned
within said hollow cylindrical body for rupturing said sealing
member and moving toward said outlet end; and
wherein said rod means is separable from said piston; and further
including means for holding said piston separately from said rod
means, within said hollow, cylindrical body;
whereby injection fluid stored and preserved within the hollow
cylinder may be removed via the outlet end by the piston under the
influence of the rod means.
2. A syringe according to claim 1, wherein said sealing surface is
a surface of a first flange facing axially away from said hollow,
cylindrical body; said sealing member is in the form of a hollow
member having a substantially conical closed first end, said
sealing member surrounding a portion of said piston, being inserted
between said piston and the interior wall of said body and having a
second end in the form of a second flange located exteriorly of
said body, said second flange being joined to said first
flange.
3. A syringe according to claim 2, further including a second
sealing member covering the rear of said piston, said second
sealing member being joined to said first flange via said second
flange so as to hold said piston within said body.
4. A syringe according to claim 2, wherein said sealing member is
provided with a rupture region defined by a thickness reduction
therein substantially adjacent said first flange.
5. A syringe which may be used for storage and preservation of
injection fluid comprising, in combination:
a. a hollow, cylindrical body having an outlet end and an inlet
end;
b. a rupturable member at said outlet end;
c. means defining a sealing surface at said inlet end;
d. a sealing member which is fixed to said sealing surface to seal
said inlet end;
e. rod means; and
f. a piston connected to said rod means and movably positioned with
respect to said hollow cylindrical body for entering its interior,
rupturing said sealing member and moving toward said outlet
end;
wherein said sealing surface is a surface of a first flange facing
axially away from said hollow, cylindrical body; and
wherein said sealing member is composed of a member which
intimately, adhesively adheres to a portion of said piston, said
portion being located within the interior of said body, said
sealing member having a free portion in form of a second flange,
and said first flange being joined to said second flange in a
fluid-tight manner
whereby injection fluid stored and preserved within the hollow
cylinder may be removed via the outlet end by the piston under the
influence of the rod means.
6. A syringe which may be used for storage and preservation of
injection fluid comprising, in combination:
a. a hollow, cylindrical body having an outlet end and an inlet
end;
b. a rupturable member at said outlet end;
c. means defining a sealing surface at said inlet end;
d. a sealing member which is fixed to said sealing surface to seal
said inlet end;
e. rod means; and
f. a piston connected to said rod means and movably positioned with
respect to said hollow cylindrical body for entering its interior,
rupturing said sealing member and moving toward said outlet
end;
wherein said sealing surface is a surface of a first flange facing
axially away from said hollow, cylindrical body;
wherein said sealing member and said piston are one and the same
member, this member being of a material suitable for prolonged
contact with the stored fluid within said body and being provided
with a second flange which is joined to said first flange to
provide a sealed fluid-tight closure for said body; and
wherein said second flange is provided, at its joint with that
portion of said sealing member constituting said piston, with a
region of reduced thickness constituting a rupture area
whereby injection fluid stored and preserved within the hollow
cylinder may be removed via the outlet end by the piston under the
influence of the rod means.
7. A syringe according to claim 6, wherein said rod means includes
a tip portion having an enlargement having a diameter which is
substantially equal to the outer diameter of that portion of said
sealing member constituting said piston; and said enlargement, at
its end facing said body is terminated by a sharply angled edge
forming a circular blade which permits cutting between said second
flange and that portion of said sealing member constituting said
piston when said tip is pushed into the interior of said body.
Description
BACKGROUND OF THE INVENTION
This invention relates to a syringe which may be used as a
container for storing and preserving fluids which are to be
injected and, more particularly, to such a syringe which may
contain its own injection fluid which is thus stored in sterile
condition and ready to be used.
In medicine and especially in radiology, it is often necessary to
administer numerous injections of contrast material during
prolonged periods of time which requires sterilization operations.
These operations require much time and effort.
To reduce the time and effort, at least to a considerable extent,
it is known to employ "ready to use" syringes, i.e., syringes which
are sold and stored in a sterile envelope. These syringes, which
are generally plastic, are disposed of after use. However, this
technique still requires a time-consuming manipulation to fill the
syringe with injection fluid, which has been separately stored and
preserved in a separate sealed container.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a syringe which
contains its own injection fluid in a sterile manner.
It is another object of the present invention to provide a syringe
which advantageously stores and preserves its own injection fluid
in a sterile fashion ready for use.
It is an additional object of the present invention to provide a
syringe which is at least partially disposable and is of relatively
simple construction.
The foregoing objects, as well as others which are to become clear
from the text below, are achieved in accordance with the present
invention by providing a syringe which may be used for storage and
preservation of injection fluid. The syringe includes a hollow
cylindrical body which has an outlet end and an inlet end. A
rupturable member is provided at the outlet end. A flange or the
like is provided at the inlet end. A sealing member, which is
desirably a fluid-impermeable membrane, is fixed to the flange or
the like to seal the inlet end. A rod is provided on which a piston
is connected. The piston is positionable, with respect to the
cylindrical body, for entering its interior, rupturing the sealing
member and moving toward the outlet end. The movement of the
piston, under the influence of the rod, causes the injection fluid
stored and preserved within the hollow cylinder to be removed via
the outlet end.
The syringe according to the invention desirably has at its outlet
end a rupturable member in the form of a breakable sealed nipple. A
first flange, on which there is a fixed, fluid-impermeable
membrane, constituting the sealing member, is provided to store and
to preserve the injection fluid contained in the syringe in a
fluid-tight fashion. The membrane is ruptured by the motion of the
piston toward the outlet end of the syringe.
In accordance with a preferred embodiment of the invention, the
syringe includes a piston which is also made of plastic material,
such as polypropylene, which is resistant to the injection fluid.
The piston, in this case, also includes a second sealing flange or
the like integral with the piston and joined, by fusing or other
techniques, to the first flange formed on the body of the syringe.
At the place where it is joined to the piston, the second flange
has a rupturable region formed by a reduction of its thickness.
In a preferred variant of the preferred embodiment mentioned above,
the piston is hollow and its associated piston rod has a tip which
conforms to the interior shape of the piston. At a distance equal
to the depth of the piston, the tip carries an enlargement of its
diameter equal to that of the piston. This enlargement terminates
at a steep angle directed toward the syringe body in order to
facilitate the separation of the flange attached thereto.
The invention is to be better understood, and other characteristics
and advantages are to become apparent with the aid of the below set
forth detailed description and the figures of accompanying
drawing.
BRIEF DESCRIPTION OF THE DRAWING
FIG. 1 is a side view of a syringe according to an illustrative
embodiment of the present invention.
FIG. 2 is an exploded, perspective view showing the syringe of FIG.
1, its membrane, piston, and piston rod being shown.
FIG. 3 is an axial, sectional view through a syringe according to a
first variant of the embodiment shown in FIGS. 1 and 2.
FIG. 4 is an axial, sectional view through a syringe according to
another variant of the embodiment shown in FIGS. 1 and 2.
FIG. 5 is an axial, sectional view of a most preferred embodiment
of a syringe according to the present invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
As visible in FIG. 1, an illustrative embodiment of a syringe
according to the present invention includes a hollow, cylindrical
body 1, an outlet end of which is equipped with an attachment known
per se.
The attachment is defined by a sleeve 2 having interior threads
intended to be used to attach the syringe to a needle, a valve, or
a catheter, or some other accessory for utilization. At the center
of the sleeve 2 is a thin, rupturable member, such as a tube, with
a sealed, fluid-tight tip (see 20 FIG. 5) intended to be cut off
prior to connecting the attachment sleeve 2 to the accessory needle
or the like. The tip is intended to be broken easily, for example,
by parting, with or without a rupture, along a circumferentially
extending line of weakness.
At the other end, which is the inlet end, the hollow, cylindrical
body 1 of the syringe has a first flange 3 whose open face is
finished to permit sealing with a sealing member 4 (membrane) or a
lid by gluing, or fusing, or some other known technique. The
purpose of the sealing member 4 is primarily to hold the liquid in
the syringe and to prevent its coming in contact with materials
which can adulterate it during storage. The entire assembly, that
is the syringe and sealing member 4 is kept sterile in a
fluid-tight enclosure during storage just as in the case of storage
of empty syringes. As illustrated in FIG. 2, which is an exploded,
pictorial view of the syringe of FIG. 1 showing its lid 4 half
removed, the head of a piston 5 which includes a sealing, stiffener
flange 6, a point 7 and a seat 8 for a piston rod 9 is further
shown.
The head of the piston 5, and possibly its associated rod 9 as
well, are kept sterile outside of the syringe in a fluid-tight
envelope, which can be the same one that contains the syringe
proper.
The use of the syringe, shown in FIGS. 1 and 2, thus requires
tearing off or preparation of the sealing member 4, and putting the
piston 5 in its place within the hollow, cylindrical body 1.
One of the principal applications of any syringe constructed
according to the present invention is for the injection of contrast
material during radiographic examinations. In that case, the
syringes are used in combination with a suitable, automatic
injection apparatus which mechanically controls the advance of the
pistons as a function of the desired flow rate. The movement of
these pistons is relatively powerful and precise, this fact being
used to assure rupture of the sealing members.
For this purpose, one end of the piston 5 is in the shape of a
point 7. Thus, in the use of the syringe, one places the piston 5
on an end of the rod 9, which may be connected to an automatic
injection apparatus, and one places the syringe which includes the
body 1 together with its associated sealing member 4 in its holding
cradle (not shown).
The apparatus which acts upon the piston rod 9 pushes the piston 5
whose point 7 pierces the sealing member 4. The resulting pieces of
the sealing member 4 are pushed between the interior wall of the
hollow, cylindrical body 1 of the syringe and the piston 5. The
sealing member 4 is sufficiently thin and the sealing flange 6 of
the piston 5 is sufficiently elastic to make this passsage
possible.
In a variant of the syringe illustrated in FIGS. 1 and 2, shown in
axial cross-section in FIG. 3, the syringe includes a hollow,
cylindrical body 1 which is equipped with a piston 5 after being
filled and prior to having a sealing member (membrane) 11 attached.
However, the prolonged contact of the piston 5 and the injection
fluid can be detrimental to good preservation of the fluid. For
this reason, a sealing member (membrane) 10 is placed between the
piston 5 and the fluid within the hollow, cylindrical body 1. In
order to facilitate the insertion of the sealing member 10 when the
syringe is being filled, it has substantially the shape of a bell
or the like, or of a cylinder having a closed cone at one end.
FIG. 3 is an illustration of a section through the syringe
partially showing the hollow, cylindrical body 1, the piston 5, a
flange 3, and the rod 9. The piston 5 has same shape as the
embodiment of FIGS. 1 and 2, and includes a point 7. The sealing
member 10 is shaped as a cylinder having a closed-cone
configuration on one end, the other end being open. The sealing
member 10 almost completely surrounds the piston 5 and is pressed
against it. Its free, open end, which forms a second flange, is
fused or otherwise fixed to the first flange 3, as in the
embodiment shown in FIGS. 1 and 2. The sealing member 11, which is
planar, is superimposed over the sealing member 10 at the rear
portion of the piston 5 in order to hold it in place.
The use of the syringe illustrated in FIG. 3 is even simpler than
the one shown in FIGS. 1 and 2, because it is sufficient to merely
place it in its holding cradle (not shown). A piston rod 9,
actuated by an automatic injection apparatus, ruptures the sealing
member 11 and subsequently pushes the piston 5 whose point 7
pierces the sealing member 10, the remaining pieces of which are
pushed against the internal wall of the hollow, cylindrical body 1
just as in the embodiment of FIGs. 1 and 2.
In yet another variant based on the structure of FIG. 3 when the
syringe is placed into operation, the piston 5 ruptures the sealing
member 10 near the line of its attachment to the flange 3 and not
at its closed end. For this purpose, the thickness and/or the
strength of the sealing member 10 is lower in the vicinity of the
flange 3 than in the other parts of the same sealing member 10.
This reduction of the thickness and/or the strength, which
constitutes a rupture region for the sealing member 10, is
obtained, for example, by the partial removal of portions of the
material of the sealing member 10 during the operation of fusing or
otherwise fixing the sealing member 10 on the flange 3. After
rupture has occurred in the vicinity of its fusing line, the
sealing member 10 is pushed along by the piston 5 during its entire
travel within the hollow, cylindrical body 1.
In still another variant, which is illustrated in FIG. 4, a sealing
member (membrane) 12 replaces the sealing member 10 (FIG. 4) and is
a part of a piston 5, i.e., the elastic material of the piston 5,
which should not come in contact with the fluid, is covered with a
plastic foil which constitutes the sealing member 12, the foil
adhering to the piston 5. The plastic foil constituting the sealing
member 12 extends radially outward from the rear portion of the
piston 5 and forms a second flange 13 so that the sealing can be
affixed to the first flange 3. When the syringe is placed in
operation, the flange 13 separates from that part of the sealing
member 12 adhering to the piston 5 because of displacement of the
piston 5 by a piston rod 9. The plastic foil constituting the
sealing member 12 is sufficiently thin and flexible so that it can
produce an acceptable fluid tightness between the piston 5 and
hollow, cylindrical body 1 of the syringe during the entire travel
of the piston 5. Furthermore, the piston 5 and the sealing member
12 stick together and the sealing member 12 is fused to the edge of
the flange 3 of the syringe; consequently, it is no longer
necessary to provide a second sealing member, such as sealing
member 11 (FIG. 3) in order to hold the piston 5 within the body
1.
As shown in axial section in FIG. 5, the most preferred embodiment
of the invention, includes a hollow, cylindrical body 1 of the
syringe which terminates at its output end as a sleeve 2 including
a fluid-tight tip 20 intended to be cut off or otherwise ruptured
during use. At its entry end, the body 1 of the syringe is
terminated by a first flange 3 by means of which the body 1 is held
in position in an injection apparatus at one end face; the other,
free, face having a plane, annular form lying perpendicular to the
axis of the body 1, is equipped with a sealing member (membrane)
which closes it in a fluid-tight manner; and also constitutes a
piston 50 which is provided with a number of sealing, stiffener
flanges 6 which contact the interior wall of the body 1.
In this preferred embodiment, the piston 50 of the syringe is
itself made of a relatively flexible plastic material which is
resistant to the injection fluid contained permanently in the
syringe body 1 prior to its utilization. Such a choice of materials
makes it possible to omit the sealing member 4, 10, and 12, (FIGS.
2 and 3, 4) and to manufacture a sealing assembly, comprising the
piston 50 and a second sealing flange 51, out of one single piece
of plastic, for example, polypropylene. Prior to the use of the
syringe, the piston 50 is held fixed in the interior of the syringe
body 1, and the second flange 51 is fused to the free face of the
first flange 3, in such a way as to insure the fluid-tightness and
sterility of the fluid contained within the syringe body 1.
The thickness of the second flange 51, at the points where it is
joined to the piston 50, is reduced in thickness by a groove 52 in
order to create a rupture region between the piston 50 and the
flange 51 which permits easy separation when the piston 50 is
pushed into the body 1 of the syringe under the action of an
operating rod 9.
In a preferred variant of this embodiment, the piston 50 is itself
hollow and a tip 90 at the end of the operating rod 9 has the same
shape as the interior of the piston 50. In effect, the piston 50
constitutes an assembly comprising a flexible piston and a sealing
member where one part of the body of the piston 50 is formed in a
shape complimentary to the tip 90, which is made of a rigid
material.
Incidentally, the tip 90, at a distance of its end corresponding to
that between the interior bottom of the piston 50 and its junction
with the second flange 51, carries an enlargement 91 whose outer
diameter is approximately equal to the outer diameter of the piston
50. The enlargement 91 terminates in an edge with a sharp angle 92
facing the syringe body and forming a kind of circular blade
intended to cut the junction 52 between the second flange 51 and
the major portion of the piston 50.
In the same embodiment, the piston 50 is hollow and flexible and
essentially constitutes a sealing assembly and carries at least one
or preferably the several sealing stiffener flanges 6 of classical
annular form, such as are described previously and shown in FIG. 3,
as well as an end reinfforcement 60 of considerable length and
terminated at a sharp angle facing the outlet end of the syringe.
When the tip 90 is completely pushed into the hollow piston 50, the
end reinforcement 60 is strongly pressed against the internal wall
of the syringe body 1 and insures excellent sealing between the
piston 50 and the body 1.
Such syringes are really ready to use. They are especially adapted
to use in automatic injection systems and apparatus, especially to
those which, because of prolonged injection times, use a mechanism
wherein several syringes are placed into operation successively and
where an empty syringe must immediately be replaced by a full
one.
It is to be appreciated that the foregoing description of preferred
embodiments and variants thereof are set out by way of
illustration, not of limitation. Numerous other embodiments and
further variants are possible within the spirit and scope of the
invention, the scope being defined by the appended claims.
* * * * *