U.S. patent number 3,900,028 [Application Number 05/445,852] was granted by the patent office on 1975-08-19 for injection site for sterile medical liquid container.
This patent grant is currently assigned to American Hospital Supply Corporation. Invention is credited to Charles J. McPhee.
United States Patent |
3,900,028 |
McPhee |
August 19, 1975 |
Injection site for sterile medical liquid container
Abstract
An injection site for a parenteral liquid bottle with an
improved structure and assembly method for securing a puncturable
diaphragm to a closure of the bottle. The closure is formed with an
integral upstanding tube that has an internal flange at its outer
end. A rubber diaphragm and a tubular retainer are telescopically
inserted into the upstanding tube from the tube's inner end before
the closure is assembled to the bottle. The retainer squeezes the
diaphragm against an undersurface of the flange to form a seal and
the retainer is locked in this position. After the closure is
joined to the bottle, the entire joint between the upstanding tube
and the retainer is inside the bottle and protected from external
bacterial contamination.
Inventors: |
McPhee; Charles J. (Sylmar,
CA) |
Assignee: |
American Hospital Supply
Corporation (Evanston, IL)
|
Family
ID: |
23770453 |
Appl.
No.: |
05/445,852 |
Filed: |
February 26, 1974 |
Current U.S.
Class: |
604/415;
215/247 |
Current CPC
Class: |
A61J
1/1406 (20130101) |
Current International
Class: |
A61J
1/00 (20060101); A61J 001/00 () |
Field of
Search: |
;128/272,214D,214C,214R,214.2,DIG.24,227
;215/DIG.3,247-253,264,292,309,200 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: McGowan; J. C.
Attorney, Agent or Firm: Barger; Larry N. Merrick; Robert
T.
Claims
I claim:
1. A container connected to a tube that has a puncturable
resealable diaphragm secured within this tube, wherein the
improvement comprises:
a container with a preformed opening therein; a closure with a
rigid transverse wall spanning the container opening, with a
periphery of the closure joined to the container at a hermetic
seal; said transverse wall having an opening that is substantially
smaller than the container opening and spaced from said hermetic
seal; a rigid tube integrally formed with the transverse wall
without any seam or joint therebetween, said tube having a passage
communicating with the transverse wall opening; an inwardly
extending flange integrally formed with the tube without any seam
or joint therebetween; and a tubular retainer within said tube and
spaced from said heremetic seal; said retainer, rigid tube, and
flange combining to confine the diaphragm, and said retainer and
flange engaging the diaphragm to form a hermetic seal whereby all
external joints between the container and closure are remote from
the diaphragm.
2. The combination as set forth in claim 1, wherein there is a
locking means maintaining the retainer in a fixed relationship to
the flange.
3. The combination as set forth in claim 2, wherein said tube and
retainer are rigid, and one of the tube and retainer has an annular
groove and the other has a deformed section extending into said
groove forming the locking means.
4. The combination as set forth in claim 3, wherein the retainer
has one end portion that compressingly engages the puncturable
resealable diaphragm and has an annular groove at an opposite end
of the retainer, and said tube has an annular deformed bead
extending into said groove.
5. The combination as set forth in claim 4, wherein the closure
including the tube has an inner surface adjacent the groove in the
retainer; and said retainer has an inner end surface adjacent said
groove, whereby alignment of the two inner surfaces insures a
proper compression of the diaphragm between the flange and
retainer.
6. The combination as set forth in claim 1, wherein the rigid tube
extends outwardly from the transverse thermoplastic wall.
7. The combination as set forth in claim 6, wherein the rigid tube
has an outer end and the flange is adjacent this outer end.
8. The combination as set forth in claim 7, wherein the closure's
transverse wall, outwardly extending rigid tube, and internal
flange are formed of a homogeneous mass of thermoplastic
material.
9. The combination as set forth in claim 1, wherein the retainer
includes a rigid puncture support member for a central portion of
the puncturable resealable diaphragm.
10. The combination as set forth in claim 9, wherein the rigid
puncture support member includes an annular collar engaging an
inner surface of the diaphragm and the diaphragm has a peripheral
area extending outwardly from the annular puncture support collar,
and this peripheral area is hermetically sealed between the tube's
flange and the retainer.
11. The combination as set forth in claim 10, wherein the retainer
has an annular recess between the rigid puncture support and an end
portion of the retainer that compressingly squeezes the diaphragm
against the flange, whereby the diaphragm can at least partially
deform into said recess when its peripheral area is under
compression.
12. The combination as set forth in claim 11, wherein the diaphragm
has an upwardly offset central portion, and this offset portion is
supported on its under surface by the rigid puncture support
collar.
13. The combination as set forth in claim 12, wherein the
puncturable resealable diaphragm has an indicia indicating the
location of a center passage through the rigid puncture support
collar of the retainer.
14. The combination as set forth in claim 13, wherein the indicia
is an upstanding ring on an outer surface of the diaphragm.
15. The combination as set forth in claim 1, wherein the flange is
located at an outer end of the rigid tube and includes an inwardly
beveled approach surface of the flange.
16. The combination as set forth in claim 1, wherein the
puncturable resealable diaphragm is rubber.
17. The combination as set forth in claim 1, wherein the
compressive forces on the puncturable resealable diaphragm are in a
direction parallel to a longitudinal axis through the rigid
tube.
18. The combination as set forth in claim 17, wherein the diaphragm
is free of any substantial hoop compression.
19. An injection site structure connected to a sterile medical
liquid container comprising: a rigid thermoplastic inner closure
having a transverse wall hermetically sealed to an opening of the
container; a rigid upstanding thermoplastic tube integrally formed
with the transverse wall and extending upwardly from said
transverse wall; an inwardly extending thermoplastic flange
integrally formed with an upper end portion of the upstanding tube,
said flange having a beveled lead-in surface and an under surface;
a rubber puncturable resealable diaphragm having an upwardly offset
center portion and a peripheral sealing portion fitting within said
tube and having an upper annular peripheral surface in abutting
engagement with the under surface of said flange; a rigid
thermoplastic tubular retainer fitting within said rigid upstanding
tube and compressingly squeezing an annular peripheral portion of
the rubber diaphragm into hermetic sealing engagement with the
under surface of said flange; a rigid thermoplastic tubular
retainer fitting within said rigid upstanding tube and
compressingly squeezing an annular peripheral portion of the rubber
diaphragm into hermetic sealing engagement with the under surface
of the flange; a locking means securing the retainer in a fixed
position within said upstanding tube; a peelable foil secured to an
outer end of said upstanding tube; and an outer cap fitting over
said upstanding tube and foil, said outer cap being frangibly
secured to the bottle.
Description
BACKGROUND
Sterile medical liquid such as parenteral solution is commonly
infused into a patient's vein from a container hanging above the
patient. The sterile liquid flows by gravity through a tubular
administration set connected at one end to the container and at an
opposite end to a venous needle in the patient.
Sterile parenteral solutions, such as 5% dextrose, normal saline,
etc. are frequently supplied to the hospital in sealed sterilized
containers. These containers are partially filled with liquid and
have sterile air occupying the remainder of their volume. This is
so that additive medication can be added to the air space of the
container and mixed with the liquid of the bottle prior to
administering to the patient. Many of the sterile medical liquid
containers include what is termed as a "injection site" through
which these additive medications can be injected. The injection
site includes a rubber diaphragm through which a hypodermic needle
of a syringe or a pointed hollow spike of an additive container can
be inserted. After withdrawal of the needle or spike the diaphragm
reseals.
In the past these rubber diaphragms have been secured to the
containers by a series of external clamping structures. These
external clamps which included crimped metal rings, tape bands,
etc., compressively sealed the edges of the rubber diaphragm to the
container structure.
When these external clamp members were not sufficiently crimped or
tightened a small liquid seepage could occur at the edge of the
puncturable rubber diaphragm. Such a small seepage in this area
could be beneath the external clamp and hidden from view. Although
many scientific tests are performed to determine there is no
leakage or seepage in this area, it would be a definite advantage
to have an additional visual test of any seepage.
SUMMARY OF THE INVENTION
The present invention provides an improved injection site which
requires no separate external clamping devices which might cause
cracks, crevices, seams, etc. and where liquid seepage would be
hidden from view. This invention provides an injection site
structure that includes a rigid upstanding thermoplastic tube
integrally formed with a thermoplastic inner closure of the bottle.
This rigid tube has an integral inwardly extending thermoplastic
flange at its outer end. Before the inner closure is assembled to
the bottle a puncturable rubber diaphragm and a tubular retainer
are pre-assembled. This diaphragm and retainer are telescopically
inserted into an inner end of the upstanding tube and the retainer
squeezingly compresses the rubber diaphragm against an under
surface of the tube's integral flange to form a hermetic seal. With
this structure the inner closure presents a homogenous mass of
thermoplastic material of the inner closure, integral upstanding
tube, and integral flange that externally supports the rubber
diaphragm. There is no seam, cracks or crevices between the flange
and upstanding tube. If there were any liquid seepage around the
edge of the rubber diaphragm it would be readily visible on a top
surface of the diaphragm. While such liquid seepage would be
extremely rare, it is a definite advantage to visually see such
seepage.
Other advantages of the improved injection site include three
important structural advantages. First, the tubular retainer
confines substantially all compressive forces against the rubber
diaphragm in a direction parallel to the longitudinal axis of the
upstanding tube so there is no substantially hoop compression on
the edges of the diaphragm. Hoop compression used to seal prior
rubber diaphragms to injection sites sometimes cause additional
binding on the hypodermic needle puncturing the diaphragm.
Secondly, the tubular retainer has a rigid puncture support collar
that supports an underside of the diaphragm surrounding its
principle puncturing target to prevent excessive downward
deflection of the diaphragm during puncture. This prevents
excessive distortion stresses from being transferred to the
peripheral sealed area of the diaphragm. Thirdly, the puncture
support collar fits into a recess on the underside of the diaphragm
for aligning the diaphragm and the retainer prior to insertion of
this preassembled unit into the rigid tube of the injection
site.
THE DRAWINGS
FIG. 1 is a front elevational view of the medical liquid container
as it is supplied to the hospitals;
FIG. 2 is an enlarged perspective view of an upper end of the
container showing its outer cap removed;
FIG. 3 is a top plan view of a puncturable resealable diaphragm
portion of the injection site;
FIG. 4 is a sectional view taken along line 4--4 of FIG. 3.
FIG. 5 is an enlarged sectional view showing the method of
assembling the injection site;
FIG. 6 is an enlarged sectional view of the injection site that has
been assembled;
FIG. 7 is a further enlarged sectional view of the upper portion of
the injection site showing the compressed edge of the diaphragm;
and
FIG. 8 is a further enlarged sectional view of a lower portion of
the injection site showing the means for locking the tube and
retainer together.
DETAILED DESCRIPTION
Referring to these drawings bottle 2 is shown in FIG. 1 having a
neck 4 with an external flange 6. Secured to flange 6 is an outer
cap 8 which houses the injection site. The bottle 2 is supported by
a series of feet such as 10 and 12 at its lower end. Between feet
10 and 12 is a recess 14 that contains a hinged hanger 16. A front
of the bottle has a label 21c located between calibrations 21a and
21b.
Within the bottle is a sterile liquid 18 and a sterile gas 19, such
as air. It is into this air space 19 that an additive medication
can be injected immediately prior to administering the liquid 18.
It is to such an injection site that this invention relates.
In FIG. 2, the perspective view shows the outer cap 8 removed from
the bottle to expose the inner cap and the injection site. This
outer cap is shown frangibly connected to the bottle by a series of
frangible webs. The precise details of this outer cap are described
in my copending application entitled, "Three Barrier Closure System
for Medical Liquid Container," Ser. No. 445,834. Alternatively,
this outer cap could be a frangible cap such as disclosed in a
copending application entitled, "Frangible Closure System for
Medical Liquid Container and Method of Making Same," Ser. No.
338,685, invented by Pradip Choksi.
The inner closure of FIG. 2 includes a transverse wall 22 that is
joined to an upstanding collar 24 which is permanently sealed to
container neck collar 26. Integrally formed with the inner closure
transverse wall 22 is an upstanding rigid thermoplastic tube 28
that has an outlet structure for connecting to an administration
set through which liquid is dispensed to the patient. Also
integrally formed with transverse wall 22 is a rigid upstanding
tube 30 that forms a portion of the injection site structure which
is indicated generally at 20.
Hermetically sealing off the outer end of both rigid tubes 28 and
30 is a thermoplastic metal foil 32 which is shown in FIG. 2. This
foil 32 is preferably in two portions so that the foil can be
peeled back from either tube without interfering with the foil's
seal to the other tube. This foil on rigid tube 30 is peeled back
immediately before use to expose a puncturable resealable diaphragm
34.
The puncturable resealable diaphragm 34, shown in the enlarged top
view of FIG. 3, includes a peripheral sealing portion 36 and a
central puncture portion 38. Puncture portion 38 is surrounded by
an upstanding target ring 40 that acts as a guide for locating the
hypodermic needle or puncturing spike on the diaphragm. As shown in
FIG. 4, the central puncturing area 38 is offset upwardly from
peripheral sealing portion 36 and thus forms a recess 42 in a
bottom side of the diaphragm. The purpose of recess 42 and its
relationship to a tubular retainer and puncturing support section
will be explained later.
The construction of the injection site and method of assembly is
shown in more detail in FIG. 5. Here, rigid tube 30 is clearly seen
as have its lower end integrally formed with transverse wall 22 of
the inner closure. There are no seams, cracks, crevices, etc.
between rigid tube 30 and transverse wall 22. An upper end of the
rigid tube has an integral inwardly extending thermoplastic flange
44. This flange also has no joints, cracks, crevices, etc. between
the flange and rigid tube 20. The flange 44 has a beveled lead-in
surface 46, a downardly directing sealing surface 48, and an inner
surface 50. This inner surface 50 defines an opening through which
the diaphragm can be punctured.
In the procedure for assembling the injection site the diaphragm 34
is fitted onto a rigid tubular retainer 52 to form a sub-assembly.
An upper end 54 of the tubular retainer 52 engages peripheral
portion 36 of diaphragm 34. The tubular retainer also includes a
rigid puncture support collar 56 that is supported by transverse
member 58. Above transverse member 58 is a recess 60 into which the
squeezed peripheral portion 36 of the diaphragm is relieved when
compressively sealed against under surface 48 of flange 44.
FIG. 5 shows how the rigid puncture support collar 56 fits within
recess 42 of diaphragm 34 to align the diaphragm with opening 50 of
the flange of rigid tube 30. The sub-assembly of diaphragm 34 and
tubular retainer 52 is telescopically inserted into an inner end of
the rigid tube 20 until the peripheral section 36 of the diaphragm
is tightly gripped between an upper end 54 of the retainer and an
under surface 48 of flange 44. When this occurs the diaphragm 34
takes on the configuration as shown in FIG. 6. Here the peripheral
area 36 is tightly squeezed to form a hermetic seal and a portion
of the squeezed diaphragm forms an annular bulge 62 that is
relieved into annular recess 60 of the retainer. The diaphragm is
sufficiently squeezed when the lower ends of the retainer and tube
are in substantial alignment. At a lower end 64 of retainer 52 is
an external recess 66. A portion 68 of the lower end of rigid tube
20 is deformed by heat and pressure to create an annular rib or
flange that extends into recess 66. There is also some deformation
of the retainer at its lower end as shown in FIG. 8. This
construction locks the retainer 52 into rigid tube 30 to
continually squeeze the diaphragm against the under surface 48 of
flange 44.
At the top of FIG. 6 the operation of the rigid support collar 56
is shown during a needle puncture. Here the rigid support collar 56
supports an area of the diaphragm immediately outward of the target
ring 40. Thus, when hypodermic needle 70 is forced through
diaphragm 34, support collar 56 will prevent excessive strain and
deflection of the diaphragm from being transmitted to the critical
hermetic seal area 36. Also in FIG. 6 the compressive forces on
area 36 of diaphragm 34 are substantially all in a direction
parallel to a longitudinal axis 72 through the injection site. The
diaphragm 34 in this construction is relieved of inwardly directed
hoop forces tending to laterally compress the diaphragm 34 against
cannular 70. Such hoop compression could cause the needle to bind
as it passes through diaphragm 34. Some of the previous puncturable
resealable diaphragms relied on a hoop compression around the
peripheral of the diaphragm for making a seal with the
closures.
FIG. 7 has a more detailed view that shows the compressed area 36
of diaphragm 34 that is tightly squeezed between surface 48 and
surface 54 of the flange and retainer respectively.
In FIG. 8 the enlarged sectional view at the bottom end of the
injection site shows in more detail how rib 68 is deformed into the
annular recess to lock tubular retainer to the tube 30.
The method of assembling the unique injection site of this
invention includes placing the diaphragm 34 on retainer 52 and
aligning it with the rigid puncture support collar 56. Next the
sub-assembly is telescopically inserted into a lower end opening of
rigid tube 20 as shown in FIG. 5 and moved into tube 20 until
peripheral section 36 of the diaphragm 34 is tightly compressed in
a hermetic seal. Next the lower end of rigid tube 20 is deformed by
heat and pressure to form a rib 68 that occupies at least a portion
of groove 66 to lock retainer 52 to rigid sleeve 20. The inner
closure, diaphragm 34 and retainer 52 forms a unit that is next
connected to thermoplastic metal foil 32.
After the foil has been attached, the inner closure is fitted to
the neck of a liquid containing bottle 2. Then the collar 24 and
the inner closure 26 of the container are heat fused together.
Finally the outer cap 8 is fitted over the inner closure and
secured to the bottle flange by fusing a flange 9 of the closure to
bottle flange 6.
It has been found that the above described invention works very
well when the bottle, inner closure with integral tubes 28 and 30,
and tubular retainer are all made of a propylene-ethylene
thermoplastic. Preferably, the puncturable resealable diaphragm 34
is of natural or synthetic rubber.
In the above description a specific embodiment has been used to
illustrate the invention. However, it is understood that persons
skilled in the art can make modifications to this embodiment
without departing from the spirit and scope of the invention.
* * * * *