U.S. patent number 3,890,953 [Application Number 05/241,727] was granted by the patent office on 1975-06-24 for electrical apparatus generating a low frequency, alternating magnetic field for promoting the growth of bone and other body tissues.
This patent grant is currently assigned to Werner Kraus. Invention is credited to Werner Kraus, Hans-Dieter Viehbach.
United States Patent |
3,890,953 |
Kraus , et al. |
June 24, 1975 |
Electrical apparatus generating a low frequency, alternating
magnetic field for promoting the growth of bone and other body
tissues
Abstract
The growth or repair of fractured bones or the growth of other
body tissues is promoted by means of a coil which is applied to
produce a magnetic field at the site in which growth is to be
encouraged. The coil is supplied with a low frequency alternating
voltage below 50 Hz. A device is applied to the body or implanted
in the body in order to concentrate the magnetic field produced by
the coil.
Inventors: |
Kraus; Werner (Munich,
DT), Viehbach; Hans-Dieter (Aisingerwies,
DT) |
Assignee: |
Kraus; Werner (Munich,
DT)
|
Family
ID: |
5804066 |
Appl.
No.: |
05/241,727 |
Filed: |
April 6, 1972 |
Foreign Application Priority Data
Current U.S.
Class: |
600/14; 600/12;
602/2 |
Current CPC
Class: |
A61F
2/30 (20130101); A61N 1/40 (20130101); A61N
2/02 (20130101); A61B 17/58 (20130101); A61F
2002/2821 (20130101) |
Current International
Class: |
A61B
17/58 (20060101); A61F 2/30 (20060101); A61N
1/40 (20060101); A61N 2/00 (20060101); A61N
2/02 (20060101); A61F 2/28 (20060101); A61n
001/42 () |
Field of
Search: |
;128/1R,1.3,1.5,82.1,404,405,411,418,419R,422 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
|
|
|
|
|
|
|
970,276 |
|
Sep 1958 |
|
DT |
|
954,128 |
|
Apr 1964 |
|
GB |
|
Primary Examiner: Kamm; William E.
Attorney, Agent or Firm: Spencer & Kaye
Claims
What is claimed is:
1. In an electrical apparatus for promoting the growth of bone and
other body tissues by the application thereto of a low frequency
alternating magnetic field, such apparatus having current
generating means and field applicator means, the improvement
wherein the applicator means comprises a flat solenoid coil having
an axis about which the coil is wound and composed of a plurality
of parallel and flexible windings, each said winding having two
adjacent elongate portions and two 180.degree. coil bends joining
said elongate portions together, said coil being flexible in the
coil plane in the region of said elongate portion for being bent
into a U-shape, said coil being bent into such U-shape about an
axis parallel to the coil axis and adapted for connection to a
source of low frequency alternating current.
2. In an electrical apparatus for promoting the growth of bone and
other body tissues by the application thereto of a low frequency
alternating magnetic field, such apparatus having current
generating means and field applicator means, the improvement
wherein the applicator means comprises a U-shaped flat solenoid
coil having an axis about which the coil is wound and composed of a
plurality of parallel windings, each said winding having two
adjacent, elongate U-shaped portions and two 180.degree. coil bends
joining the ends of said elongate portions together, the coil being
curved in such U-shape about an axis parallel to the coil axis and
adapted for connection to a source of low frequency alternating
current.
3. In an electrical apparatus for promoting the growth of bone and
other body tissues by the application thereto of a low frequency
alternating magnetic field, such apparatus having current
generating means and field applicator means, the improvement
wherein the applicator means comprises: a plurality of solenoid
coils each having an axis about which such coil is wound and
disposed adjacent one another with their axes parallel and adapated
for connection to a source of low frequency alternating current,
and hinge means connecting adjacent coils together for pivotal
movement about axes parallel to the axes of said coils.
4. An arrangement as defined in claim 3 wherein said coils having a
cylindrical cross section.
5. An arrangement as defined in claim 3 wherein said coils have an
elliptical cross section.
Description
BACKGROUND OF INVENTION
1. Field to which Invention Relates
The present invention relates to an apparatus for promoting the
growth of bone and other body tissues.
It is known that the shifting of an electrochemical equilibrium
exisitng in a living organism can lead to a change in a mechanical
state in the organism. Proceeses of this type are continuely taking
place in muscle tissue. Furthermore the contraction and expansion
of fibers of collagen, that is to say the connective tissue
substance, has been observed to take place following a change in
the concentration of a salt solution surrounding the fibers.
One example of the reversability of this principle is offered by
the piezoelectric behavior of bone: In this case electrical
deformation potentials, which arise owing to mechanical loading of
bone fiber, regulate the dynamic equilibrium between the free
calcium and phosphate ions in the blood, on the one hand, and the
bound calcium and phosphate ions in the crystal lattice of the
hydroxyl apatite on the other.
The changes in state occurring are thus due to the disturbance of
an existing mechanical-chemical equilibrium between free and bound
ions. The restoration of the original electro-neutrality is
determined by the speed of diffusion of the free ions and the
statistical distribution in the vicinity of the bound ions.
2. The Prior Art
In accordance with a previous proposal the reunion of fractured
bones was to be encouraged by alternating electric currents, which
were produced by means of a pick-up coil which was attached to a
splint (induction splint) serving for holding the bone in place.
The splint had electrodes which extended into the gap of the
fracture and the like.
In the case of clinical application of "induction splints" of the
proposed type effects were observed which cannot be completely
explained on the basis of the galvanic action of the induced
currents. On the basis of the above-mentioned considerations the
idea then arose that electro-dynamical occurrences -- and such
occurrences are involved in the case of the above-described
mechanicalchemical changes in equilibrium -- must be accompanied by
corresponding magnetic fields and that it should, however, also be
possible to produce corresponding chemical and physical reactions
by the action of electromagnetic fields in biological sytems.
Experiements carried out along these lines, which were aimed at
distinguishing the biological actions of the electric field and
that of the magnetic field, proved this assumption to be correct.
It was found in this respect that the application at certain times
and at certain locations of electromagnetic fields led to growth of
bone and other body tissues. As a consequence of the action of the
magnetic field a formation of new vessels occurring as a primary
factor was detected.
SUMMARY OF INVENTION
On the basis of these discoveries one aim of the present invention
is to provide an electrical apparatus for promoting the growth of
bone and other body tissues.
The present invention resides in an electrical apparatus for
promoting the growth of bone and other body tissues comprising a
generator for the supply of low frequency alternating current with
a frequency below 150 Hz, a coil which can be connected with the
output of the generator and whose shape is adapted to the shape of
the body part in which the growth of tissue is to be promoted and
to the structure of the tissue to be grown, and a device which can
be applied to the body part for concentration of the field produced
by the coil on to the zone of the body in which the tissue is to be
grown. The device which can be applied to the body part can if
necessary be implanted in the body.
With the apparatus in accordance with the invention substantial
successes in healing have already been obtained in practice. For
example in the case of severe accident casualities involving
fractures, the time for repair of the fracture was reduced to half
the normal time required for healing. Furthermore, the healing of
bed sores could be brought about or substantially accelerated.
LIST OF FIGURES OF DRAWINGS
Further development of the invention are defined in the
subclaims.
In what follows embodiments of the invention will be described with
reference to the accompanying drawings in detail.
FIG. 1 is a diagrammatic representation of a generator and a field
coil of an apparatus in accordance with one embodiment of the
invention.
FIGS. 2 and 3 show in perspective other types of field coils for a
device in accordance with the invention.
FIG. 4 is a sectional view of a fractured thigh bone with a marrow
or Kuntscher nail or pin, which comprises a field-concentrating
device in accordance with one embodiment of the invention.
FIG. 5 is a diagrammatic representation of an applied compression
screw, which also comprises a fieldconcentrating device in
accordance with the invention.
FIG. 6 shows a splint with embedded or inserted magnetic cores for
the purpose of field concentration.
FIG. 7 shows a device for field concentration which can be
implanted.
FIG. 8 shows a Kuntscher nail or pin, which comprises a magnetic
core serving both for field concentration and also the inductive
production of a galvanic current in the bone region.
DESCRIPTION OF PREFERRED EMBODIMENTS
The apparatus shown diagrammatically in FIG. 1 comprises a AC
generator 10, which supplies low frequency AC at the output
terminals 12. The frequency of the AC lies below 150 Hz, for
instance between 1 and 50 or 65 Hz. It has been found particularly
favorable to use a frequency range between 5 or 10 and 30 Hz, for
example 25 Hz. The half cycles of the alternating current should
have comparatively gently sloping leading and trailing flanks (rise
and fall times of the half cycles being for example in the order of
magnitude of a quarter to an eighth of the length of a cycle); the
AC can thus be a sinusoidal current with a low non-linear
distortion, for example less than 20 percent, or preferably less
than 10 percent, or a triangular wave current.
The rise and decay times of the cycles can be in the order of one
quarter to one eighth of the cycle.
It is also possible for the current to consist of sinusoidal or
triangular pulses with alternating polarity, which alternate either
individually or in pairs with pulse intervals. It is clearly
important in all cases that the front and trailing flanks of the
current pulses or AC half cycles should slope relatively slightly.
The rise and fall times are preferably substantially greater than 5
ms (corresponding to a sinusoidal current of 50 Hz), and preferably
at least approximately 8 to 10 ms, for example up to 80 ms.
On the AC signal it is possible to superimpose a DC component
and/or an AC component with a higher frequency by means of a
modulating device contained in the generator 10. The frequency of
the component with the higher frequency can amount, for example, to
three to 10 times the basic frequency of the AC signal. It is also
possible for a DC component to be superimposed on the AC signal so
that the latter is asymmetric with respect to the zero line.
The output terminals 12 of the generator 10 are connected with a
field coil 14, which in the case of the embodiment shown comprises
an insulated copper ribbon in the form of an U-shaped flat coil on
a flexible flat core. The windings of the coil thus comprise two
respective bends of 180.degree.between which long relatively
adjacently running longitudinal parts lie, which are bent in a
U-shape. The particular shape of the coil is selected for producing
a magnetic field B, whose direction is adapted to the structure of
the bone or other body tissue whose growth is to be promoted. If,
for example, an extremity 16, as indicated in broken lines, for
example a thigh with a fractured femur is to be treated, the
magnetic field B preferably runs in the direction in which the
thigh bone is loaded during normal use, and the function of the
blood vessels is encouraged.
Preferably, however, it is not only the spatial orientation of the
magnetic field which is adapted to the circumstances present in the
living organism, but also the timing. In additon to known spatial
structures of bone and other body tissues, the timing of the effect
is also of significance. The most important change with time of the
mechanical influences acting on the substance of the organism from
the inside follows the heart beat. The rhythm and form of the
spread of the pressure wave of the blood in the organism determine
the metabolic events with their biochemical and biophysical
reactions to a substantial extent. For this reason actuation and/or
control of the generator 10, and thus of the electromagnetic fields
produced, is provided for by the systolic pressure wave in the zone
of application. This can be carried out in particular with a pulse
pressure wave detector 18, which is applied adjacent to the
treatment zone between the latter and the heart on the body part to
be teated.
The actuating pulse produced at the pulse detecting device 18 in
accordance with the systolic pressure wave can be used in a
generator 10 for initiating an individual oscillation cycle or for
the synchronisation of a continuous oscillation of the output
current.
In accordance with a further possibility the systolic pressure
change detected by the pulse detector 18 directly controls the
variation in the output current of the generator 10.
A further possibility resides in that the pulse produced from the
pulse detector 18 initiates an output current oscillation produced
by a function generator, for example a magnetic tape device, with
the shape of the function corresponding to the systolic pulse
pressure wave of a healthy person with blood vessels which are
still elastic, more particularly a young person.
FIG. 2 shows another embodiment of a field coil which can be used
for the present device. The field coil in accordance with FIG. 2
consists of a number of flat coils 14a, the shape of whose windings
is indicated in the case of the uppermost coil by solid lines 20.
The flat coils 14a can comprise ferromagnetic laminations and are
connected at the sides corresponding to bends in the windings in a
hinged manner so that the field coil 14', consisting of the flat
coils connected in parallel or in series, can be applied as desired
about a body part in order to induce in the latter a magnetic
field, whose direction is indicated by the double arrow B, the
paths of fields of the individual coils being indicated by
broken-line loops.
The flat coils 14a can on the other hand be connected at the end
faces 15 in a hinging manner with each other, if the field coil is
required for treating the spinal column for example.
The field coil 14" in accordance with FIG. 3 corresponds in
principle with the field coil in accordance with FIG. 2 with the
exception that the coils 14b, which are connected together in a
hinged manner, have a circular cross-section.
Instead of flat coils 14a or coils 14b with a circular
cross-section it is naturally also possible to use other suitable
coil forms, for example coils with an elliptical cross-section.
As a coil a cylindrical or solenoid coil 40'" is to be used, as
indicated in FIG. 4.
If desired the distribution of windings on the field coils can be
uneven in order to obtain a field concentration. For example the
winding density in the case of the coils 14', -" and 14'" can
increase from the outside in an inward direction or it is possible
to connect additional narrower coils which can be slid on in order
to achieve the desired field distribution.
The solenoid coil 40'" in FIG. 4 has such a large internal diameter
that it can be slid over an extremity to be treated, for example a
thigh 22, for example when the healing of the fractured femur 24 is
to be promoted. The bone 24 is pinned in a conventional manner with
a Kuntscher nail 26 or pin, in whose interior a field concentrating
device of a rod-shaped body 28 of ferromagnetic material with a
high initial magnetic permeability and a low remanence is used,
that is to say a magnetically "soft" material. The body 28 is fixed
by staples 30 in the desired position. It brings about a
concentration of the magnetic field at the site of the fracture 32.
The core is coated with an inert polytetrafluoroethylene layer. In
a manner similar to the arrangement to be described with reference
to FIG. 7, it is also possible to provide several cores with a
spacing between them in the nail or pin and between the cores a
relatively strong leak field occurs which promotes growth. This
leak field extends into the gap in the fracture or the site of the
fracture.
FIG. 5 shows a so-called compression screw 34, which is provided
with an axial hole, in which a ferromagnetic body 36, serving for
field concentration, is located, which preferably is also made of a
magnetically soft material.
FIG. 6 shows a splint which can be implanted or support plate as is
conventional in principle for fixing fractured bones, with which it
is connected by screw means. In the construction shown in FIG. 6
there is, however, the novel feature that it comprises embedded or
inserted bodies 40 of ferromagnetic material in order to bring
about a concentration of the magnetic field produced by the field
coil adjacent to the fractured bone.
Since with the invention a comparatively rapid restoration of the
bone and other body tissue can be achieved it is possible to make
the splint 38 and other corresponding support structures (pins
etc.) so as to be substantially lighter than has been the case to
date. For example the splint 38 can be made of plastics material
and can be used only for fixing the bone fracture parts, since the
bone will be rapidly repaired to such an extent that it can carry
the load itself.
Preferably such support structures are made of organic material,
for example cut or milled from animal bone. This material, which
must be freed of protein, may then possibly be absorbed by the
living body, can then possibly be absorbed or taken up by the body,
so that subsequent treatment is substantially simplified. The
production of bone fracture support parts such as pins or nails,
plates, half-shells and screws of bone substance or synthetically
produced molded parts, which are treated with calcium and
orthophosphates and can be taken up by the body, offers advantages
not only with the present purpose.
FIG. 7 shows a further apparatus for producing a field
concentration. It comprises a flexible tube 42 of an inert material
such as polyethylene, in which rod-shaped bodies 44 of a
metnetically soft material with a high permeability are embedded.
The flexible tube 42 can be shrunk after the insertion of the
bodies in order to fix the bodies 44 with a spacing between them.
The flexible tube with the bodies 44 can then be embedded in the
tissue to be renegerated.
The position of the magnetic core 44, see FIG. 7, in the flexible
tube 42 can also be fixed by means of distance pieces 43, such as
pieces of polytetrafluoroethylene, which are arranged between the
cores.
The marrow or Kuntscher nail 26' or pin shown in FIG. 8 comprises,
as is the case with the nail 26 in accordance with FIG. 4, a
magnetic core 28', which serves for field concentration at the site
of fracture. Furthermore the core carries at least one winding 46,
in which the low frequency magnetic field produces an alternating
voltage. The ends of the winding are connected with bare
platinum-iridium electrodes 48, which may be in the form of wires
or metal sheet. The electrodes are arranged on an insulated section
50 of the outside of the nail or they can be embedded in an
insulated manner in the outside of the nail. The alternating
current flowing between the electrodes 48 through the fracture site
also encourages the healing process and callus formation, as has
already been proposed in connection with the splint.
Instead of using magnetically soft material, it is also possible to
use a ferromagnetic material with a relatively low remanence, which
is so selected that a certain premagnetisation can be set and this
premagnetisation has superimposed on it the alternating
magnetisation as produced by the field coil. The same effect can be
achieved by superimposing a DC component on the AC supply to the
field coil.
It is naturally possible for other coil and magnetic core
arrangements to be used in order to concentrate the low frequency
alternating magnetic field adjacent to the organism, in which the
growth or regeneration of tissue is to be promoted. The direction
of the magnetic field lines then preferably runs parallel to that
of the fiber or vessel structure.
All parts coming into contact with the body substance consist of a
physiologically compatible material, at least on their surface.
* * * * *