U.S. patent number 3,889,674 [Application Number 05/420,641] was granted by the patent office on 1975-06-17 for mixing syringe.
Invention is credited to Constabile A. Cilento.
United States Patent |
3,889,674 |
Cilento |
June 17, 1975 |
Mixing syringe
Abstract
This invention comprises a mixing syringe which has a chamber in
both the barrel portion and plunger portion of the syringe. One
component to be mixed is placed into the plunger chamber, the
plunger slideably inserted into the syringe barrel and rotatably
oriented so that the barrel and plunger chambers are not in
alignment. At the time of use, a second component is drawn into the
syringe, the plunger rotated to align the plunger and barrel
chambers, and the plunger withdrawn until the components come into
contact and mix.
Inventors: |
Cilento; Constabile A.
(Bridgeton, NJ) |
Family
ID: |
23667270 |
Appl.
No.: |
05/420,641 |
Filed: |
November 30, 1973 |
Current U.S.
Class: |
604/518;
604/82 |
Current CPC
Class: |
A61M
5/31596 (20130101) |
Current International
Class: |
A61M
5/315 (20060101); A61m 005/22 () |
Field of
Search: |
;128/218M,218P,218D,218R,218DA,215,218NV,220,218PA,234,235,272,DIG.28
;206/219,221 ;222/136,386 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: McGowan; J. C.
Attorney, Agent or Firm: Berman, Bishoff & Platt
Claims
What I claim is:
1. A syringe capable of storing and mixing substances comprising a
barrel having a nipple opening at one end, a plunger receiving
opening at the other end, and a chamber formed on the surface of
said barrel by the outward protrusion of a section of said surface;
a plunger slidably disposed within said barrel, said plunger having
seals on an upper and lower portion and between said seals a
chamber formed in said plunger by the inward intrusion of a section
of the surface of the plunger surface, said plunger being rotatable
in said barrel to align said outward protrusion and said inward
intrusion to form a single chamber for mixing of a substance
contained within the syringe.
2. A syringe as in claim 1 wherein said outward protrusion on said
barrel is a longitudinal shaped section comprising up to half of
the circumference of said barrel.
3. A syringe as in claim 2 wherein said inward intrusion on said
plunger is a longitudinal shaped section comprising up to half of
the circumference of said plunger.
4. A syringe as in claim 3 wherein said barrel chamber and said
plunger chamber when aligned form a symmetrical chamber.
5. A syringe as in claim 4 wherein said symmetrical chamber is
ellipsoidal in shape.
6. A syringe as in claim 1 wherein there is a cap seal on said
barrel at said inlet-outlet opening whereby the internal surfaces
of said syringe are maintained antiseptic.
7. A syringe as in claim 1 wherein a solid substance is contained
within said chamber formed by said inward intrusion on said
plunger.
8. A syringe as in claim 1 wherein said barrel at said nipple
opening has a cannula.
9. A method of mixing at least two substances using a syringe
comprising:
a. providing a syringe having an outward protruding chamber on the
barrel portion and an inward intruding chamber on the plunger
portion, said plunger being rotatable within and sealing against
said barrel portion;
b. inserting a first substance into the chamber on said plunger and
aligning said plunger so that said plunger chamber is not in
alignment with the chamber on said barrel portion;
c. drawing a second substance up into the barrel;
d. rotating said plunger so that said plunger chamber and said
barrel chamber are in alignment; and
e. withdrawing said plunger from said barrel a sufficient distance
such that the plunger allows mixing of said first and second
substances.
10. A method of mixing as in claim 9 wherein during step (e) said
syringe is maintained in an upwardly pointing orientation with said
plunger being drawn downwardly from said barrel.
11. A method of mixing as in claim 10 wherein after step (e) said
syringe is pointed downwardly whereby the mixed substances occupy a
space in said syringe adjacent the nipple opening.
12. A method of mixing as in claim 11 wherein said plunger is slid
downwardly until it contacts said mixed substances.
13. A method of mixing as in claim 12 wherein said first substance
is a solid and said second substance is a liquid.
14. A method of mixing as in claim 9 wherein said first substance
is a solid and said second substance is a liquid.
Description
This invention relates to a syringe. More particularly, this
invention relates to a mixing syringe having a barrel chamber and a
plunger chamber, and wherein one of the substances which is mixed
in the syringe is contained within the plunger chamber until
mixing. When the plunger chamber and barrel chamber are aligned and
the plunger extended partially from the barrel, the contained
substance mixes with a second substance which has been drawn into
the syringe barrel.
There are many uses for mixing syringes in the medical and
analytical chemical arts. Generally in the instances when these
syringes are used one of the components is not stable in the
presence of one or more of the other substances. The substances are
therefore mixed just prior to use. As an example, a freeze-dried
substance, for instance for use in inoculations, can be placed in
the syringe immediately after sterilization of the syringe and
maintained in a sterile-dry condition for a period of time. Just
prior to use, water or an aqueous solution can be drawn into the
syringe for mixing with the freeze-dried substance. After
preferably shaking to effect faster dissolution, the solution is
ready for use. In another use a sterile liquid can be stored in the
syringe and subsequently mixed with a second liquid. There are yet
many other uses for a mixing syringe, and particularly for such a
syringe which can store a substance to be mixed in a dry and/or
sterile state.
Various types of mixing syringes are known in the prior art. U.S.
Pat. No. 2,541,621 discloses a syringe wherein a solid tablet or
other material can be added to a syringe and dissolved within the
syringe. The disadvantages of this syringe are that one of the
components is not stored within the syringe and that the syringe
will not be antiseptic since the barrel and plunger are exposed to
the atmosphere. U.S. Pat. No. 1,456,469, although not a mixing
syringe, has an interesting structure. This is a refilling syringe
wherein the material to be injected is stored outside of the
syringe but enters the syringe through an opening in the barrel
wall. The plunger has a longitudinal groove so that added liquid
can reach the cannula end of the barrel during filling. However,
this syringe will not store a substance and subsequently mix it
with another substance.
The mixing syringe of this invention has many advantages over prior
mixing syringes and comprises a syringe and plunger, each of which
has a chamber section. The barrel chamber is a protruding chamber
which extends only partially around the circumferential surface of
the barrel and preferably extends less than half the
circumferential distance around this surface. Otherwise the shape
of this chamber may vary, with a longitudinal elongated shape being
preferred. This barrel receives a rotatable plunger at one end, and
at the other end has means for the attachment of a conventional
cannula. The plunger has two seals or sets of seals, one near each
end of the plunger. Intermediate the ends of the plunger and
between the seals is an indented plunger chamber. This indented
chamber may be of any shape, but like the barrel chamber does not
extend around the full circumferential surface of the plunger, and
preferably it extends around less than half the circumference of
the plunger. Otherwise the shape of this chamber may vary, with a
longitudinal elongated shape being preferred. In a specifically
preferred embodiment, the shapes of the barrel chamber and plunger
chamber are complementary in that they form a symmetrical space
such as an ellipsoid, or ovoid when aligned.
It is therefore a prime object of this invention to set out a
mixing syringe which maintains one component to be admixed isolated
in an antiseptic condition, but which allows for a fast and easy
means of mixing within the syringe and for administration of the
admixed substances.
Other objects and advantages of this invention will be apparent
during the course of the following detailed description.
FIG. 1 is a side elevation of the syringe in a horizontal
orientation.
FIG. 2 is a cross-sectional view of the syringe taken substantially
on the line 2--2 of FIG. 1.
FIG. 3 is a vertical cross-sectional view of the syringe taken
substantially on the line 3--3 of FIG. 2 showing the barrel chamber
and plunger chamber in a non-aligned condition.
FIG. 4 is a vertical cross-sectional view of the syringe similar to
that of FIG. 3 showing the barrel chamber and plunger chamber in
alignment.
FIGS. 5-7 are vertical cross-sectional views of the syringe similar
to that of FIG. 4, illustrating the manipulative steps for mixing
substances within the syringe.
In the form of the invention shown in FIG. 1, there is provided a
syringe having a barrel 10, preferably of cylindrical formation.
The surface of barrel 10 protrudes outwardly at 11 thereby forming
barrel chamber 12. This barrel chamber preferably comprises a
section of less than half the circumference of the barrel cylinder.
The barrel chamber may be of any reasonable shape or size, with a
longitudinal extending shape being a preference. This barrel
chamber is located distal to the ends of the barrel and preferably
near the mid-region. The syringe barrel terminates in a flange 13
at one end which aids in gripping the syringe, and in a sloping
bottom wall 14 which terminates in apertured nipple 15 at the other
end. Cap seal 16 covers the apertured nipple so that an antiseptic
environment can be maintained within the syringe.
The plunger 17 is rotatably and slideably disposed in barrel 10 of
the syringe and has a flange 18 at one end and a sloping bottom
wall 19 at the other end. The sloping wall of the plunger is
complementary with the sloping bottom wall 14 of the barrel.
Between the ends of the plunger there are two seals 20 and 21
carried on the plunger. These seals may be O-ring seals or any
other equivalent and suitable sealing means. Intermediate the
plunger seals is a plunger chamber 22 formed by the indentation of
plunger surface 23. This plunger chamber may be of any shape but
preferably is longitudinally shaped and comprises less than half
the circumference of the plunger. In the embodiment shown in the
drawings the barrel chamber and plunger chamber when in alignment
form an ellipsoid having its major axis along a projection of the
plunger barrel contact surface. The elipsoid shape is a preferred
shape for these chambers.
FIG. 2 shows the syringe in cross-section with the barrel chamber
12 and plunger chamber 22 in a non-aligned condition. On the
rotation of the plunger 17 the two chambers can be aligned. FIG. 3
is a vertical cross-section showing one substance 24 stored in
plunger chamber 22 and another substance 25 contained in the barrel
in the space between the plunger sloping wall and the barrel
sloping bottom wall. This component 25 is usually a liquid and is
inserted by being drawn up through apertured nipple 15. At this
time the cap seal 14 may be replaced with cannula if desired. When
the plunger in FIG. 3 is rotated the plunger chamber and barrel
chamber can be made to align as shown in FIG. 4. The component 24
is then disposed within the combined plunger chamber-barrel
chamber.
FIGS. 5-7 show the manipulative steps for mixing substances 24 and
25 shown in FIG. 4. In a first step the plunger 17 is withdrawn out
of the barrel a sufficient distance so that the substances 24 and
25 can intermix. The syringe can be in almost any orientation
during this step. Preferably the syringe is held in an upward
orientation, that is, as shown in FIG. 5 with the nipple end of the
barrel pointing upwardly. In this orientation the substances mix.
The syringe can be shaken in order to enhance mixing. After mixing
is essentially complete the syringe is oriented as shown in FIG. 6,
with the nipple end of the barrel pointing downwardly. In this
orientation the mixture flows out the barrel chamber 12 and plunger
chamber 22 to a point in the nipple end of the barrel. Air in the
syringe occupies the volume of the barrel chamber and plunger
chamber. The original source of this air was from the barrel
chamber and plunger chamber. The plunger 17 is then pushed
downwardly with the syringe maintained in the same orientation as
shown in FIG. 7. The mixed substances are now ready for
administration or some other use.
The syringe barrel and plunger can be constructed out of glass,
metal, plastics or combinations of these materials. These are the
usual syringe construction materials. The seals 20 and 21 and cap
seal 16 can be fabricated out of rubber or any suitable elastomeric
material. Various known techniques can be used to construct the
syringe components. The barrel and plunger are constructed
separately and then assembled. The syringe can be sterilized by the
syringe manufacturer, with a subsequent addition of the contained
component 24 to the plunger chamber in an antiseptic atmosphere, or
the sterilization can be performed by the user just prior to
inserting the contained substance into the plunger chamber.
Various changes in the shape, size and arrangement of parts may be
made to the syringe herein shown and described without departing
from its scope. Such changes, in order to adopt the syringe to a
specific use, are obvious to those in the art.
* * * * *