U.S. patent number 3,888,253 [Application Number 05/477,487] was granted by the patent office on 1975-06-10 for device for administration of medicines.
This patent grant is currently assigned to Beecham Group Limited. Invention is credited to Peter Ridgway Watt, Harold George Wilkinson.
United States Patent |
3,888,253 |
Watt , et al. |
June 10, 1975 |
Device for administration of medicines
Abstract
A device for the oral inhalation of finely divided solid
medicaments, which comprises within a housing a capsule holder
fixed to an elongate vibratable member which is fixed to the
housing. A capsule in the capsule holder is pierced and inhalation
by a patient causes the vibratable member to vibrate, medicament is
shaken from the capsule and inhaled into the patient's lungs.
Inventors: |
Watt; Peter Ridgway (Ewhurst,
EN), Wilkinson; Harold George (Goring-by-Sea,
EN) |
Assignee: |
Beecham Group Limited
(EN)
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Family
ID: |
27259363 |
Appl.
No.: |
05/477,487 |
Filed: |
June 7, 1974 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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382214 |
Jul 24, 1973 |
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Foreign Application Priority Data
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Aug 4, 1972 [GB] |
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36428/72 |
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Current U.S.
Class: |
128/203.15;
128/203.21 |
Current CPC
Class: |
A61M
15/0028 (20130101); A61M 15/0041 (20140204); A61M
15/0036 (20140204); A61M 15/0031 (20140204); A61M
2202/064 (20130101) |
Current International
Class: |
A61M
15/00 (20060101); A61m 015/00 (); A61m
015/06 () |
Field of
Search: |
;128/198,206,208,266 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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1,338,254 |
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Nov 1973 |
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GB |
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1,118,341 |
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Jul 1968 |
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GB |
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Primary Examiner: Medbery; Aldrich F.
Parent Case Text
This is a continuation, of application Ser. No. 382,214 filed July
24, 1973, and now abandoned.
Claims
We claim:
1. A device for the oral administration of finely divided solid
medicaments which device comprises a hollow housing, an elongate
semi-flexible vibratable member which is fixed adjacent one end
thereof within the housing and free at the other end, a capsule
holder attached to said end of the vibratable member at a point
remote from its fixed end; said housing having inlet and outlet
vents permitting air to flow through the housing, the outlet vent
being adapted for application to or insertion into the mouth; and
means for causing said member to vibrate comprising directed air
flow means reacting with said flexible vibrating member.
2. A device according to claim 1 wherein the air flow means for
causing said member to vibrate is provided by the construction and
arrangement of said inlet vents such that a turbulent airstream is
caused to flow through the housing between the vents by the intake
of breath by the user which flow in turn causes said member to
vibrate.
3. A device according to claim 1 wherein the air flow means for
causing said member to vibrate is provided by the construction and
arrangement of air flow control means on the interior of the
housing such that a turbulent airstream is caused to flow through
the housing between the vents by the intake of breath by the user
which flow in turn causes said member to vibrate.
4. A device according to claim 1 which device has only one outlet
vent.
5. A device according to claim 1 wherein the elongate vibratable
member is in the form of a rod which is able to vibrate in any
direction at right angles to its axis.
6. A device according to claim 5 wherein the rod is of circular
cross-section.
7. A device according to claim 1 wherein the vibratable member is
in the form of a long narrow flat strip, such that its primary
component of vibration is in a single plane.
8. A device according to claim 2 wherein the housing is provided
with a plurality of inlet vents in the region of the capsule
holder.
9. A device according to claim 8 wherein said inlet vents are
angled such that incoming air is directed to a circular path.
10. A device according to claim 8 wherein said inlet vents are
positioned adjacent internal angled barriers such that incoming air
is directed to a circular path.
11. A device according to claim 7 wherein the cross-sectional area
of the outlet vent is of the same general magnitude as the total
cross-sectional area of the inlet vents.
12. A device according to claim 1 wherein the capsule holder is
provided with a protuberance adapted to strike the inner walls of
the housing when the vibratable member vibrates.
13. A device according to claim 1 wherein the capsule holder is in
the form of a cup adapted to securely carry a capsule.
14. A device according to claim 1 wherein the capsule holder has a
passage to allow a flow of air from within the hollow housing to
one end of the major axis of the capsule.
15. A device according to claim 1 which device is provided with
means for piercing the capsule in situ in the device.
16. A device according to claim 15 which device is provided with
means for piercing the capsule at both ends of the major axis
thereof.
17. A device according to claim 16 wherein the means of piercing
the end of the capsule nearest to the outlet vent is in the form of
a sharpened piercing member mounted within the hollow housing
coaxial with the capsule holder.
18. A device according to claim 17 wherein the sharpened piercing
member is slidably mounted within the housing.
19. A device according to claim 17 wherein the sharpened piercing
member is fixed within the housing and the device is provided with
means for moving the capsule holder towards the piercing
member.
20. A device according to claim 16 wherein the means for piercing
the end of the capsule furthest from the outlet vent is in the form
of a sharpened hollow piercing member attached to the capsule
holder onto which a capsule may be impaled.
21. A device according to claim 1 wherein the housing is separable
into two parts.
22. A device according to claim 19 wherein the two parts of the
housing are adapted to be reassembled by means of a screw
thread.
23. A device for the oral administration of finely divided solid
medicaments which device comprises a hollow housing separable into
two parts adapted to be reassembled by means of a screw thread; an
elongate semi-flexible vibratable rod of circular cross-section
which is able to vibrate in any direction at right angles to its
long axis and which is fixed towards one end thereof within the
housing and free at the other end; a capsule holder attached to
said end of the vibratable rod at a point remote from its fixed
end, the capsule holder being in the form of a cup adapted to
securely carry a capsule, having a passage to allow a flow of air
from within the hollow housing to one end of the major axis of the
capsule and having a protuberance adapted to strike the inner walls
of the housing when the vibratable rod vibrates; said housing
having one outlet vent and a plurality of inlet vents permitting
air to flow through the housing, the outlet vent being adapted for
application to or insertion into the mouth and the inlet vents
being in the region of the capsule holder and angled such that
incoming air is directed to a circular path, and in turn causes
said rod to vibrate; the device being provided with means for
piercing the capsule at both ends of the major axis thereof in situ
in the device, the means of piercing the end of the capsule nearest
the outlet vent being in the form of a sharpened piercing member
fixed within the housing coaxial with the capsule holder and means
for moving the capsule holder towards the piercing member, the
means for piercing the end of the capsule furthest from the outlet
vent being in the form of a sharpened hollow piercing member
attached to the capsule holder onto which a capsule may be
impaled.
24. A device for oral administration of finely divided solid
medicaments which device comprises a hollow housing separable into
two parts, an elongate semi-flexible vibratable narrow flat strip
such that its primary component of vibration is in a single plane,
which is fixed towards one end thereof within the housing and free
at the other end; a capsule holder attached to said end of the
vibratable flat strip at a point remote from its fixed end, the
capsule holder being in the form of a cup adapted to securely carry
a capsule; said housing having one outlet vent and one inlet vent
permitting air to flow through the housing, the outlet vent being
adapted for application to or insertion into the mouth, the
cross-sectional area of the outlet being of the same general
magnitude as the cross-sectional area of the inlet vent, and the
interior of the housing having constrictions to provide a turbulent
airstream to flow through the housing between the vents by the
intake of breath by the user of the device which flow in turn
causes the said flat strip to vibrate.
Description
This invention relates to a device for the application of finely
divided solid medicaments by oral inhalation.
The application of medicaments by oral inhalation, inhalation
therapy, is of considerable value in treating ailments of the
bronchial tract and of the lungs, and the route is also of value in
the systemic application of medicaments.
In order to obtain the maximum beneficial effect the medicament
should be carried to the area to be treated in the form of fine
particles suspended in the inhaled air. In the past this has been
achieved for example, by applying the medicament with a nebuliser
or by applying the medicament from a solution or suspension in a
pressurised pack. Both of these methods are however, rather costly,
and in the case of the pressurised pack, the apparatus is not
reusable. A disadvantage of the nebuliser is the difficulty of
administering an exact predetermined dose of medicament. Devices
are known for the insufflation of powdered medicament but many
require an additional source of power besides the patients
inhalation to blow the powder out of the device. Examples of such
additional sources of power include for example a rubber squeeze
bulb (see Belgian Pat. No. 764,576) or a source of gas under
pressure (see British Pat. No. 1,305,172). In such devices it is
difficult to synchronise the patients inhalation with the operation
of the additional source of power. Other inhalation devices which
are activated solely by the user's inhalation are described in
British Pat. Nos. 1,118,341, 1,182,779, 1,122,284, 1,295,081,
1,301,856 U.S. Pat. No. 3,635,219, and Belgian Pat. No.
781,102.
According to the present invention, there is provided a device for
the oral inhalation of finely divided solid medicaments which
device comprises a hollow housing and a capsule holder fixed to an
elongate vibratable member which is fixed towards one end within
the housing at a point remote from the capsule holder, said housing
having inlet and outlet vents permitting air to flow through the
housing the outlet vent being adapted for application to or
insertion into the mouth and the interior of the housing being
constructed and arranged so that the intake of breath by the user
of the device through the outlet vent causes a turbulent airstream
to flow within the housing which in turn causes the said member to
vibrate. In use the device of this invention is first loaded by
placing a capsule containing finely divided medicament into the
capsule holder. As the patient inhales through the outlet vent the
vibratable member vibrates in the turbulent airstream which is set
up within the hollow housing and the capsule holder and the capsule
held therein vibrate along with the vibratable member. Providing
the capsule is pierced, the finely divided medicament is shaken
from the capsule by the vibration into the interior of the housing.
It is then caught up in the airstream and is carried through the
outlet vent and down into the user's lungs. It will thus be clear
that the medicament capsule must either be pierced before insertion
into the capsule holder or must be pierced in situ. This latter
method is most convenient and thus in a preferred embodiment of
this invention the device is provided with means for piercing a
medicament capsule in situ in the device.
The capsule may be pierced at any position on its surface and the
preferred position of piercing depends on the particular embodiment
of the invention, as will be discussed below.
For ease of access to the interior of the housing in order to load
the device with a medicament capsule, part of the housing may be
detachable e.g. by way of screw threads or a snap-on/snap-off
locking mechanism. The hollow housing may conveniently be long and
narrow with the vibratable member mounted longitudinally within the
housing. With this embodiment a pleasing slim shape may be
achieved.
The elongate vibratable member may be in the form of a long narrow
flat strip of a suitable material e.g. a metal or plastic reed,
such that the primary component of vibration is in a single plane
i.e., the vibration corresponds roughly to harmonic motion.
Alternatively, the vibratable member may be in the form of a rod or
spindle which is able to vibrate in any direction at right angles
to its long axis. Preferably the rod is circular in
cross-section.
A capsule holder is fixed to one end of the vibratable member.
Preferably the capsule holder is located near the air outlet in the
housing. The capsule holder may be in the form of a simple cup into
which the capsule fits securely. It is then advantageous to
position the capsule holder in a constricted neck region within the
hollow housing e.g. an approximate Venturi orifice in order to give
a minimum pressure area in the vicinity of the capsule when the
patient inhales through the air outlet vent. Alternatively the
capsule holder may be in the form of a cup which has a passage to
allow a flow of air from within the hollow housing to one end of
the major axis of the capsule.
The device of this invention also has at least one outlet vent and
one or more inlet vents. Preferably the device has only one outlet
vent, and one or more inlet vents. In the case where there is one
inlet vent, this may be in the end or in the sides of the device.
Further inlet vents may be provided in the end or the sides of the
device for example there may be one main inlet in the end and one
or more subsidiary inlets e.g. the sides of the device.
When the vibratable member is in the form of a reed, it is
preferably that the cross-sectional area of the outlet vent is of
the same general magnitude as the total cross-sectional area of the
inlet vents.
The interior of the housing of the device is constructed and
arranged so that the intake of breath by the user of the device
through the outlet vent causes a turbulent airstream to flow within
the housing which in turn causes the said member to vibrate. Such
construction depends on the method desired to achieve dispersion of
the medicament in the air stream. When the vibratable member is in
the form of a reed turbulent airflow within the housing may be
ensured by the provision of baffles within the housing and/or on
the vibratable member itself. A second possible method of producing
the required turbulence, preferred when the vibratable member is in
the form or a rod, is to provide a number of inlet vents in the
side of the device in the region of the capsule holder. Preferably
these inlets are angled or are positioned adjacent internal angled
barriers, so that incoming air is directed to a circular path.
Dispersion of the medicament from the capsule may be further
facilitated and turbulence increased by providing the capsule
holder with a protuberance, for example in the form of a disc which
is able to strike the inner walls of the housing when the
vibratable member vibrates.
Suitably the device also incorporates a means for piercing the
medicament capsule. In the embodiments wherein the capsule holder
is in the form of a simple cup preferably the capsule is pierced on
opposite sides of its major axis. When the capsule holder is in the
form having an air passage it is preferable to pierce the capsule
along its major axis so that the two ends each have one centrally
placed hole through them.
It is usually preferable to position a guard grid in the outlet
vent in order to prevent the entire capsule from being inhaled by
the patient should some mishap dislodge the capsule from the
capsule holder. In the case of patients who find it difficult to
inhale strongly the airflow through the housing may be supplemented
by an additional source of power such as a rubber squeeze bulb
which is squeezed as the the patient inhales. With such an
embodiment the bulb must be fitted to an air inlet in the housing
leaving another air outlet free to allow the user of the device to
inhale.
The invention will now be illustrated in some of its specific
embodiments with reference to the accompanying drawings
wherein:
FIG. 1 is a cross section of an oral inhalation device in
accordance with this invention;
FIG. 2 is a cross section of a second device in accordance with
this invention;
FIG. 3 is a cross section through the line A--A of FIG. 2;
FIG. 4 is a cross section of a third device in accordance with this
invention;
FIG. 5 is a cross section of a fourth device in accordance with
this invention;
FIG. 6 is a cross section of a further device in accordance with
this invention;
FIG. 7 is a cross section through the line B--B of FIG. 6;
FIG. 8 is a cross section through the line C--C of FIG. 6;
FIG. 9 is a cross-section of a further device in accordance with
this invention;
FIG. 10 is a cross-section through line D--D of FIG. 9;
FIG. 11 is a cross-section through line E--E of FIG. 9;
FIGS. 12 and 13 are cross-sections of two further, preferred
devices in accordance with this invention.
Referring first to FIG. 1 a hollow housing 1 contains capsule
holder 2 which is shown as holding a capsule 3 containing finely
divided medicament. The capsule holder 2 is mounted on the end of a
vibratable member in the form of a reed 4 which is fixed at the end
remote from the capsule holder to a projection 5 extending from the
housing. Air inlet vents 6 and air outlet vents 7 permit the
passage of air through the housing. The outlet vents 7 are adapted
to be inserted into the mouth by suitably shaping the housing in
the vicinity of the outlet vents. Baffles 8 project from the wall
of the housing in a direction normal to the logitudinal axis of the
housing and a co-operating baffle 9 is mounted on the vibratable
member. The dimensions and location of co-operating baffle 9 are
chosen to leave a small gap 11 between baffles 8 and co-operating
baffle 9. Constrictions 10 form a neck region about the capsule and
capsule holder.
In use the patient inserts the portion of the housing in the
vicinity of outlet vent 7 into his mouth having first loaded the
device with a capsule 3. The capsule may either be pierced before
loading or pierced in situ by a mechanism not shown in FIG. 1. In
order to load the device the housing is separable at points X by
screw threads (not shown). The patient then inhales through outlet
vents 7 thereby drawing air through the inlet vents 6 and thence
through the housing 1. As the airstream negotiates baffles 8 and 9
via the gap 11, an aerodynamically unstable situation arises at the
gap 11. The vibratable member begins to vibrate in the plane of the
drawing and the medicament is shaken from the pierced capsule into
the interior of the housing. It is then caught up in the airstream
and drawn down into the patient's lungs as he inhales. The
constricted neck formed by the constrictions 10 ensures a minimum
pressure area in the vicinity of the capsule thereby assisting in
the dispersal of the medicament.
FIGS. 2 and 3 represent a device similar to that of FIG. 1. Again a
hollow housing 101 contains a capsule holder 102 fitted with a
capsule 103 of finely divided medicament. A harmonically vibratable
member in the form of a reed 104 is fixed to projection 105 from
the housing at the end remote from the capsule holder 102. The
housing again may be separated at point Y and the capsule may
either be pierced before loading or pierced in situ. The housing
has inlet vents 106 and outlet vents 107. The vibratable member
carries baffles 109 positioned adjacent the inlet vents 106, with a
small gap between baffles 109 and the wall 108 of the inlet vents
106.
In operation as the patient inhales through inlet vents 107 air
flows into the device through inlet vent 106. As the airstream
negotiates the gap between baffle 109 and walls 108, again an
unstable aerodynamic situation is set up and the vibratable member
vibrates in the plane of the drawing.
FIG. 4 represents another device in accordance with this invention.
Again a housing 201 contains a capsule holder 202 fitted with a
capsule 203, the capsule holder mounted on a vibratable member in
the form of a reed 204 fixed to projection 205. The housing has
inlet vents 206 in its side and outlet vents 207. The walls 208 of
the inlet vents define slots 213. The vibratable member has mounted
thereon baffles 209 which have leading edges 212 positioned near to
and parallel to longitudinal slots 213.
As air is sucked through inlet vents 206 and thence through slots
213, the airstream plays on leading edges 212 of baffles 209 and
causes the entire vibratable member to vibrate.
FIG. 5 represents another device in accordance with this invention.
Again a housing 301 contains a capsule holder 302 fitted with a
capsule 303, the capsule mounted on a vibratable member in the form
of a reed 304 fixed within the end of the housing 305. The housing
has one inlet vent 306 in its side and outlet vents 307. The reed
304 is able to move away from inlet vent 306 and expose an annular
gap 314. The region of the housing near to the outlet 307 is
provided with a plug 315 which is drilled with a hole 316. The
cross-sectional area of the hole 316 is approximately equal to the
area of the annular gap 314 exposed at the maximum excursion
position. For example using a device with a reed about 12 mm wide
covering a circular inlet vent 306 of diameter 8 mm it is possible
to produce an ampitude of movement of some 0.5 mm at the mid-point
of the inlet vent 306. The area of the annular gap exposed at the
maximum excursion position is thus fractionally over 12 mm.sup.2.
An area of 12 mm.sup.2 corresponds also to a circular hole of about
4 mm diameter. Thus a hole 316, of diameter 4 mm is provided in the
plug 315.
In operation a pulse of air passes through the inlet vent 306
lifting the reed 304 slightly and travels on towards the outlet
vent 307. As the air reaches the plug 315 its movement is
restricted and consequently the rate of air intake is reduced and
the reed 304 closes. The contained air passes through the outlet
vents 307 so that the internal pressure is reduced, and the reed is
once again opened by the external air pressure. A continuation of
this sequence causes the reed to move up and down, and the rate at
which this happens will tend to set at a natural resonant frequency
of the reed.
FIGS. 6 to 8 represent a further device in accordance with this
invention. A hollow housing 401 contains a capsule holder 402
fitted with a capsule 403 of finely divided medicament. A
vibratable member in the form of a rod 404 is fixed to the end of
the housing. The housing again may be separated at a point Z. The
housing has inlet vents 406 and an outlet vent 407. The inlet vents
406 are in the form of holes drilled roughly tangentially in the
housing in the region of the capsule-holder 402, as shown in FIG.
7. The housing has one further inlet vent 406a near the end of the
housing to which the rod 404 is attached. The capsule holder 402
has an internal passage 417 and a circular disc 418, which is of
larger diameter than the capsule holder 402. A sharpened piercing
member 421 is slidably mounted coaxially within the housing by
means of a spider arrangement 420.
The extension of the outlet vent 407 projects slightly into the
main housing thereby forming an annular trough 422.
In operation the device is first separated at points Z loaded with
a capsule 403 and the two halves of the housing are reassembled.
The capsule is then pierced at both ends of its major axis by
moving the piercing element 421 through the capsule and out again.
The patient then inhales through the outlet vent 407 thereby
drawing air through the tangential holes 406, inducing a vortex in
the region of the capsule holder 403. Providing the flow rate is
sufficient the capsule holder 403 is thereby made to rotate in an
orbital movement such that the disc 418 strikes the inside of the
housing in a succession of light blows. The orbital movement
coupled with the tapping effect fluidises the powder inside the
capsule so that aggregates are dispersed. At the same time air is
drawn in through the inlet vent 406a, passes through the device
towards the outlet vent end 407. As the airstream reaches the
capsule holder 402, some passes into the passage 417 and thence
through the pierced capsule 403. The rapid vibration of the capsule
403 ensures that the powdered medicament issues freely from the
hole at the end nearest the outlet vent 407. The remaining portion
of the airstream from vent 406a reaches the disc 418 and causes
further turbulence in the vicinity of the capsule. As the powder
issues from the capsule it is caught up in the airstream and is
carried towards the outlet vent 407. As the stream of circulating
particles passes through the housing, centrifugal force holds
particles above a given size against the walls of the housing and
they circulate within the trough 422, while entrainment in the air
flow carries finer particles down the outlet vent 407 and into the
patient's lungs.
During their rotation in the trough 422, the large particles are
subject to attrition by rubbing themselves against the walls of the
housing so that progressively more material is released at a low
particle size and escape through the outlet vent 407.
An important benefit to be derived from this particular design is
ease of construction and assembly. The moving part does not have to
be in a critical relation with the static part and as a result of
this it is possible to form the assembly from injection mouldings
produced in low-cost moulds. Small variations in the shape and size
of the moulded parts do not matter particularly and the device
works without the necessity for close alignment.
An important characteristic of the preferred device as described
with reference to FIGS. 6 to 8 is that vibration does not take
place below a certain critical level of air flow; consequently
active release of the powdered medicament is always associated with
a certain minimum amount of lung ventilation and this ensures
effective transfer of the powder to the lungs. In general this
critical level will be at or about 30-35 1/min of air flow, but the
rate is pre-determined by the number and disposition of the holes
through which air passes into the device on suction.
It is possible by covering one such hole with the finger to ensure
that powder is released on a reduced rate of air-flow rather than
or the normal one. This feature could be of use, for example in the
administration of medicaments by adults to small children with
relatively low lung capacity.
FIGS. 9 - 11 represent a preferred embodiment of the device of this
invention. A hollow housing 501 contains a capsule holder 502 to
carry a capsule (not shown) of finely divided medicament. A
vibratable member in the form of a plastic rod 504 is fixed at one
end to the capsule holder 502 and at the other end to a push button
505 slidably mounted within one end of the housing 501.
A return spring 524 is situated between the push button 505 and an
annular stop 525.
The housing is separable into two parts by means of a screw thread
523. The housing has inlet vents 506 and an outlet vent 507. The
inlet vents 506 are in the form of holes drilled roughly
tangentially in the housing in the region of the capsule-holder 502
as shown in FIG. 10. The capsule holder 502 carries a hollow
piercing member 517 having a tapered end which is extended through
to the back of the capsule holder. The capsule holder 502 also
carries a circular disc 518 which is of larger diameter than the
capsule-holder 502. A second sharpened piercing member is fixed
co-axially within the housing near to the outlet vent 507 by means
of a spider arrangement 520. The region of the housing near to the
outlet 507 is provided with a plug 515 which is drilled with a hole
516.
In operation, the device is first separated into two parts by
unscrewing at the screw thread 523, and the capsule-holder 502
loaded with a capsule by impaling the latter onto the hollow
piercing member 517, thereby piercing one end of the capsule. The
two halves of the housing are then reassembled. The push button 505
is then depressed by hand against the spring 524, thus moving the
capsule onto the second piercing member 521 and piercing its other
end. The spring 524 then causes the return of the capsule holder to
its original position. The patient inhales through the outlet vent
507 thereby drawing air through the tangential holes 506, inducing
a vortex in the region of the capsule holder 502. The capsule
holder 502 is thus made to rotate in an orbital movement such that
the disc 518 strikes the inside of the housing in a succession of
light blows. The orbital motion coupled with the tapping effect
again fluidises the powder within the capsule. At the same time
some of the air drawn in through the inlet vents 406 passes behind
the disc 518 into extended passage 517 and thence through the
pierced capsule. As the powder issues from the capsule it is caught
up in the vortex of air and carried towards the outlet vent 507. As
with the embodiment of FIG. 6, the finer particles in the air
stream pass through the hole 516 the outlet vent 507 and into the
patients lungs. Coarser particles are held back by the annular plug
515 until they are reduced in size by attrition sufficiently to
escape through the central hole 516.
FIGS. 12 and 13 represent embodiments of the device substantially
similar to that shown in FIG. 9, but with modifications of the
method of piercing the capsule.
In FIG. 12 the end of the vibratable member in the form of a rod
604 is attached to a knob 605, integral with an outer sleeve 626
which fits over the outside of the housing 601. Again a spring 624
returns the knob and sleeve to its original position after if has
been depressed during the piercing operation. Alternatively the end
of the housing 627 which carries the knob 605 may be provided with
a coarse screw thread to co-operate with a similar thread (not
shown) on the outer surface 628 of the knob. In such an embodiment,
when the sleeve 626 is depressed it also rotates and the capsule in
the capsule holder 602 is rotates onto the fixed piercing member
621. This rotating action during the piercing produces an easier
and more reliable piercing.
A similar arrangement is shown in FIG. 13. Again the fixed end of
the rod 704 is attached to a knob 705 integral with a sleeve 726
which fits over the outside of the housing 701. The outer surface
of the knob 705 is provided with a screw thread 728 which screws
into a similar thread 727 on the end of the housing. A coiled
spring 724 is situated in the annular space between the knob 705
and the sleeve 726, one end being attached to the housing and the
other end to the sleeve. To pierce the capsule, the sleeve is
screwed in, thereby rotating the capsule contained in the holder
702 onto the fixed piercing member 721 and also imparting torsional
tension to the spring 724. When the sleeve is released, the coiled
spring exerts torsional torque to the sleeve to unscrew and return
the sleeve to its original position, thereby withdrawing the
capsule from the piercing member 721.
* * * * *