U.S. patent number 3,870,645 [Application Number 05/358,404] was granted by the patent office on 1975-03-11 for ferromagnetic compositions of matter.
This patent grant is currently assigned to Yeda Research & Development Co. Ltd.. Invention is credited to Yusuf Benmair, Ephraim H. Frei, Shmuel Yerushalmi.
United States Patent |
3,870,645 |
Frei , et al. |
March 11, 1975 |
FERROMAGNETIC COMPOSITIONS OF MATTER
Abstract
A process for the measurement of peristalsis. A ferromagnetic
composition for the measurement of peristalsis, for diagnostic and
therapeutic purposes.
Inventors: |
Frei; Ephraim H. (Rehovot,
IL), Yerushalmi; Shmuel (Rehovot, IL),
Benmair; Yusuf (Rehovot, IL) |
Assignee: |
Yeda Research & Development Co.
Ltd. (Rehovoth, IL)
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Family
ID: |
27260489 |
Appl.
No.: |
05/358,404 |
Filed: |
May 8, 1973 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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94380 |
Dec 2, 1970 |
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Foreign Application Priority Data
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Dec 3, 1969 [GB] |
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58966/69 |
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Current U.S.
Class: |
424/9.41;
252/62.62; 424/9.42; 252/62.64 |
Current CPC
Class: |
A61K
49/0409 (20130101); H01F 1/445 (20130101) |
Current International
Class: |
A61K
49/04 (20060101); H01F 1/44 (20060101); C04b
035/26 () |
Field of
Search: |
;252/62.64,62.51
;128/2A,2S ;324/41 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Vertiz; Oscar R.
Assistant Examiner: Cross; Ethel R.
Attorney, Agent or Firm: Ostrolenk, Faber, Gerb &
Soffen
Parent Case Text
RELATED APPLICATIONS
This is a continuation-in-part of Application Ser. No. 94380 filed
Dec. 2, 1970, now abandoned.
Claims
We claim:
1. A ferromagnetic composition of matter for diagnostic purposes,
consisting essentially of a magnetic physiologically acceptable
ferrite, from the group consisting of magnesium ferrite, barium
ferrite, manganese ferrite, manganese-zinc ferrite, magnesium-zinc
ferrite, and nickel ferrite, and having incorporated therewith, at
least one member from the group consisting of sorbitol and citric
acid.
2. A ferromagnetic diagnostic composition as claimed in claim 1
wherein the sorbitol comprises 3 to 6 percent by weight and the
citric acid comprises 0.3 to 0.6 percent by weight of the
composition.
3. A ferromagnetic composition of matter according to claim 1
wherein the magnetic ferrite is selected from the group consisting
of magnesium ferrite, barium ferrite, manganese ferrite,
manganese-zinc ferrite, magnesium-zinc ferrite, nickel ferrite and
mixtures of these.
4. A ferromagnetic diagnostic composition of matter according to
claim 1 containing up to 30 percent by weight of the composition of
small particle size barium sulfate.
5. A ferromagnetic composition according to claim 1, consisting
essentially of 200 parts of magnesium ferrite, 3 to 6 percent
sorbitol, 0.3 to 0.6 percent citric acid and about 30 parts
water.
6. A ferromagnetic composition according to claim 5, consisting
essentially of 120 parts magnesium ferrite and 70 parts barrium
sulfate, 3 to 6 percent sorbitol, 0.3 to 0.6 percent citric acid
and about 30 parts water.
Description
BACKGROUND OF THE INVENTION
Field of the Invention
The present invention relates to a novel method for the measurement
of peristalsis, to novel compositions of matter for diagnostic and
for therapeutic purposes.
2. DESCRIPTION OF THE PRIOR ART
Various methods have been proposed for the measurement of
peristalsis, and especially of the peristaltic movement of the
stomach and intestines in humans, but these have not been developed
into widely used and generally accepted clinical methods. Swallowed
magnets have been used in order to show peristalsis, but the
movement of the magnet, once it has been swallowed, can be followed
only with difficulty and provides only scanty information. Magnets
have been implanted in the stomach walls of laboratory animals, but
this method is not applicable to humans. The passage of barium meal
through the intestinal tract can be studied by means of X-rays, but
this involves high exposures to radiation, which considerably
limits the applicability of this method. Various ferromagnetic
compositions have been proposed for this purpose. It is also known
that the rheological properties of barium sulfate can be improved
by the addition of sorbitol and citric acid, the effect being due,
according to its discoverers, to an influence of these additives on
the sulfate ions, resulting in a better wetting of the particles.
Ferrites alone have the drawback of a lesser degree of X-ray
absorption as compared with barium sulfate. Barium sulfate by
itself gives good X-ray pictures, but it cannot be manipulated from
the outside of the body once it has been ingested.
SUMMARY OF THE INVENTION
The present invention relates to a number of improvements in the
use of ferromagnetic materials for diagnostic and for therapeutical
purposes, to novel compositions of matter for these uses and to a
novel device for the determination of the movement of ingested
ferromagnetic materials through the gastrointestinal tract.
The compositions according to the present invention are
characterized by the possibility to manipulate them from the
outside of the body by the application of a suitable magnetic
field; they have good covering properties and they can also be
viewed by X-rays. The process according to the present invention
for the measurement of peristalsis and for the determination of the
velocity of movement of ingested material through various parts of
the gastrointestinal tract and their retention therein is of
diagnostic value and can also be used as an indicator for the
functioning of various organs of the body. The movement of such
ferromagnetic materials through the gastrointestinal tract can be
monitored by various conventional means, such as X-rays,
magnetometers and the like.
DESCRIPTION OF PREFERRED EMBODIMENTS
According to the present invention there is provided an improved
ferromagnetic contrast material for diagnostic and therapeutical
purposes, which comprises in combination small particles of a
suitable ferrite sorbitol and citric acid. The ferrites so utilized
are ferromagnetic ceramic oxides containing two magnetic lattices
which are opposed to one another but which do not cancel each other
out. Ferrites which may be employed include magnesium ferrite,
barium ferrite, manganese ferrite, manganese-zinc ferrite,
magnesium-zinc ferrite, and nickel ferrite. These ferrites
generally possess a high enough magnetization, e.g., about 30
e.m.u. per gram at body temperature to permit control by external
magnetic fields. If desired, a certain quantity of barium sulfate
can be added, and this enhances the opacity towards X-rays. It is
of course to be understood that before ingestion a quantity of
water is added to these ingredients, the mixture is stirred and
thus a slurry or suspension of suitable consistency is obtained
which can be swallowed by the person to be diagnosed or treated.
Any suitable ferrite may be used which has suitable magnetic
properties, and which is physiologically acceptable, so that it can
be ingested and causes no problems during the period of time when
it passes through the digestive tract of the patient.
Advantageously there is used a ferrite of the type defined above,
which contains an excess of magnesium oxide over the
stoichiometrical ratio. An excess of about 10 percent over the
stoichiometrical ratio enhances the saturation magnetisation of the
ferrite. It is clear that also other suitable biologically
acceptable ferrites of adequate saturation magnetisation can be
used, but especially good results were obtained with magnesium
ferrite with an excess of about 10 percent magnesium oxide which
has both good magnetic and biological properties. Also the other
ferrites defined above are satisfactory in these respects. The
ferrites are prepared by conventional means, as known in the art,
and the obtained material is finely ground till a particle size of
from about 1 to 50 microns is obtained. When magnesium ferrite is
rapidly quenched immediately after sintering, there is obtained a
higher saturation magnetisation than when the material is cooled
gradually.
The novel compositions comprising sorbitol and citric acid have a
higher fluidity, and for a given fluidity there can be incorporated
greater quantities of ferrite as compared with compositions without
these two ingredients. It is clear that a lesser viscosity
facilitates the swallowing of the preparation, and that a larger
content of ferromagnetic material improves both the opacity towards
X-rays and also facilitates the movement of the ingested material
by the application of a magnetic field from the outside of the
body.
The ferrites defined above are substantially inert in the
environment of the gastrointestinal tract, and they can be
manipulated from the outside of the body by magnetic fields. They
are good contrast materials as regards coating properties and as
regards absorption of X-rays. The absorption of X-rays is inferior
to that of barium sulfate, and thus it is advantageous for certain
purposes to add a certain percentage of barium sulfate, which will
generally be from zero to about 30 percent by weight of the entire
composition of matter.
In the following there are given by way of example compositions of
matter for the above purposes. The magnesium ferrite containing an
excess of about 10 percent of magnesium oxide was obtained by
sintering of the necessary components. It is used in the form of
particles of from 1 to 50 microns. The other ferrites were prepared
in a similar manner. For therapeutic purposes an active ingredient
can be added, and when ingested, the material is monitored as it
passes through the gastrointestinal tract, and it can be held in
place at a desired location by the application of an external
magnetic field.
In the following examples the parts are parts by weight.
EXAMPLE 1
Magnesium ferrite (MgFe.sub.2 O.sub.4.10% excess of MgO) 200 parts
Sorbitol 7 parts Citric acid 0.7 parts Water 30 parts
Before use, there were mixed 100 parts ferrite, the sorbitol, the
citric acid and the water. After obtaining a homogenous suspension,
the remaining 100 parts of ferrite were added and mixing was
continued until a homogenous mixture was obtained. The resulting
suspension had a consistency similar to that of maple syrup. This
could be ingested without difficulty and gave good results when
viewed by X-rays. It could be moved in the stomach by the
application of a magnetic field from the outside of the body.
EXAMPLE 2
Magnesium ferrite (as in Example 1) 120 parts Sorbitol 8 parts
Citric acid 0.7 parts Barium sulfate (1 to 20 microns) 70 parts
Water 30 parts
All ingredients, except for 70 parts of the ferrite, were mixed and
stirring was continued till a homogenous slurry was obtained. The
rest of the ferrite was added and stirring was continued until a
homogenous mixture was obtained. The consistency of this was
similar to the composition of Example 1.
The opacity of this composition to X-rays is greater than that of
the composition of Example 1. The coating properties of the
composition are satisfactory, and it can be manipulated in the
stomach and in the other parts of the gastrointestinal tract by an
external magnetic field of adequate field strength.
EXAMPLE 3
Barium ferrite (BaFe.sub.2 O.sub.4, 10% excess of BaO) 200 parts
Sorbitol 10 parts Citric acid 1 part Water 35 parts
Before use half the ferrite, the sorbitol, the citric acid and the
water were mixed until a homogenous suspension was reached. The
remainder of the ferrite was added and mixing was continued till a
homogenous mixture was obtained. The consistency and use was the
same as in Example 1.
EXAMPLE 4
A mixture was prepared, comprising 200 parts of magnesium-zinc
ferrite instead of the barium ferrite of Example 3. The preparation
and the other ingredients were the same. The properties of the
homogenous mixture obtained were practically identical with those
of Example 3.
EXAMPLE 5
A mixture was prepared from 200 parts nickel ferrite, 4 parts
sorbitol, 0.5 parts citric acid and 30 parts water. The preparation
was the same as in Example 1. The homogenous suspension obtained
had similar properties to those of the suspension obtained in
Example 1.
EXAMPLE 6
A mixture was prepared comprising 100 parts magnesium ferrite and
100 parts magnesium-zinc ferrite, 10 parts sorbitol, 1 part citric
acid and 35 parts water. Half of the ferrite mixture was admixed
with the other ingredients, homogenized and the remainder of the
ferrite was added and homogenized. The properties and uses are like
those of the suspension of Example 1.
EXAMPLE 7
A mixture was prepared wherein instead of 200 parts barium ferrite
of Example 3 there were used 150 parts ferrite and 50 parts barium
sulfate. The other ingredients and the manner of preparation were
as in Example 3. The properties of the suspension were like those
of Example 2.
EXAMPLE 8
A mixture was prepared consisting of 100 parts of magnesium
ferrite, 50 parts manganese ferrite and 50 parts barium sulfate,
together with 8 parts sorbitol and 0.9 parts citric acid and 30
parts water. The preparation was as in Example 2 and the
consistency and properties were as those of the suspension of
Example 2.
Various compositions were prepared, and it has been found that the
quantity of the ingredients can be varied within certain limits
while still resulting in satisfactory compositions. The quantity of
sorbitol can vary from about 3 to 6 percent of the entire
composition (by weight) and that of citric acid from about 0.3
percent to 0.6 percent.
For diagnostic purposes a certain quantity of a composition of the
type exemplified in any of Examples 1 to 8 is ingested by the
person to be diagnosed, and this may be given together with some
pudding or the like. Quantities of from about 10 to 200 grams of
the composition are ingested, depending on the measurement
intended. The passage of the composition through the
gastrointestinal tract, and the arrival of the said ferromagnetic
composition at a predetermined location in the gastrointestinal
tract can be monitored. It is possible to ingest a certain quantity
of this material and to determine the retention time in the
stomach. Furthermore, the novel ferromagnetic compositions
according to the present invention are good contrast media for
X-ray examination of various parts of the gastrointestinal tract.
They can be moved by the application of an external magnetic field,
and thus facilitates the determination of the exact location of
malignant growths and the like.
The movement of the ferromagnetic compositions according to the
present invention through the gastrointestinal tract can be
monitored, as already mentioned, by the use of X-rays and also by
the use of sensitive magnetometers.
* * * * *