U.S. patent number 3,865,116 [Application Number 05/349,442] was granted by the patent office on 1975-02-11 for method of controlling tissue hypothermia.
Invention is credited to Harold W. Brooks.
United States Patent |
3,865,116 |
Brooks |
February 11, 1975 |
METHOD OF CONTROLLING TISSUE HYPOTHERMIA
Abstract
A pedicle flap is covered with a water-filled, latex rubber bag
having a surface in contact with and substantially the same size,
shape and outline as the pedicle flap. The cooling face of a
thermoelectric device is placed in contact with the exposed surface
of the bag. A thermostatic control system including a temperature
sensitive probe which is placed between the pedicle flap and the
bag maintains the predetermined temperature in the range of
15.degree.-20.degree.C. Heat generated by the thermoelectric device
is carried off by a coolant which flows through a coolant system
including a heat exchanger and a pump in series with the
thermoelectric device.
Inventors: |
Brooks; Harold W. (Danville,
PA) |
Family
ID: |
23372431 |
Appl.
No.: |
05/349,442 |
Filed: |
April 9, 1973 |
Current U.S.
Class: |
607/104 |
Current CPC
Class: |
A61F
7/10 (20130101); A61F 2007/0086 (20130101); A61F
2007/0075 (20130101); A61F 2007/0001 (20130101) |
Current International
Class: |
A61F
7/00 (20060101); A61f 007/00 () |
Field of
Search: |
;128/399,400,303.1,401,402 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Trapp; Lawrence W.
Attorney, Agent or Firm: Woodcock, Washburn, Kurtz &
Mackiewicz
Claims
What is claimed is:
1. A method of cooling a pedicle flap or graft in situ
comprising:
forming a thermal transmission medium having one surface of
substantially the same size, shape and outline as the pedicle flap
or graft to be cooled;
placing said one surface of said thermal transmission medium in
substantial contact with the entirety of the pedicle flap or
graft;
holding the cooling face of a thermoelectric device in contact with
an exposed surface of the thermal transmission medium;
maintaining a temperature sensing device in position between the
pedicle flap or graft and said one surface of said thermal
transmission medium; and
thermostatically controlling the temperature of the cooling face of
the thermoelectric device between the pedicle flap or graft and
said thermal transmission medium so as to maintain the temperature
of a substantial portion of the pedicle flap or graft at
15.degree.-20.degree. C.
2. The method of claim 1 wherein the temperature of the pedicle
flap or graft is maintained within 2.degree. C. of a preset
temperature in the range of 15.degree.-20.degree. C. over a
substantial portion thereof.
3. The method of claim 1 wherein the area of the thermoelectric
device cooling face is equal to at least 10 percent of the pedicle
flap or graft to be cooled.
4. The method of claim 1 including the step of circulating coolant
to and from said thermoelectric device so as to carry away heat
generated thereby.
Description
BACKGROUND OF THE INVENTION
This invention relates to methods for inducing hypothermia in
pedicle flaps and other types of tissue transplants.
The effect of moderate cold on living tissues and the healing of
wounds has been studied and chronicled for centuries. C. L. Kiehn
and J. D. Desprez, in an article entitled "Effects of Local
Hypothermia on Pedicle Flap Tissue," Journal of Plastic and
Reconstructive Surgery, Vol. 4, 1960, described studies involving
the cooling of experimental animal pedicle flaps to a temperature
of 15.degree.-20.degree. C. Two different systems for achieving
pedicle flap cooling are disclosed in the article. One of the
systems relies upon the circulation of a coolant through a copper
disc which is maintained in contact with the pedicle being cooled.
A thermistor is utilized as a temperature sensitive probe in the
vicinity of the copper disc but not in contact with the pedicle
flap to operate a circuit-breaker which interrupts the power to a
refrigerator unit associated with a coolant reservoir. The other
system involves the use of a dry ice reservoir which is placed in
thermal communication with the pedicle flap to be cooled by a cool
air column. In order to control the temperature, a thermistor which
is placed a considerable distance from the pedicle flap is again
utilized to actuate a circuit-breaker associated with a heating
element in the cold air column. The article fails to disclose the
relative sizes, shapes and outlines of the pedicle flap and the
copper disc on the one hand or the pedicle flap and the size of the
cold air column on the other hand. Although beneficial effects of
the hypothermia created by the systems in this article are beyond
question, the systems themselves are too cumbersome, impractical
and inexact for clinical use.
Thermoelectric devices were suggested for use in inducing local
tissue hypothermia in an article entitled "A Thermoelectric Device
for Inducing Local Tissue Hypothermia and Hyperthermia," Nature,
Vol. 203, pp. 613-614, Aug. 8, 1964, D. M. Makow and H. C. Grice.
The Makow and Grice system comprises a thermally conductive tissue
holder which is placed in thermal communication with a
thermoelectric device. However, the temperature is maintained by
placing a thermister in thermal communication with the tissue
holder but spaced from the tissue being cooled. The system is not
adapted to cool transplanted tissue in situ.
SUMMARY OF THE INVENTION
It is an object of this invention to provide a practical clinical
method for inducing transplanted tissue hypothermia in situ.
It is also an object of this invention to provide a method which is
capable of precisely maintaining the optimum temperature at the
tissue.
It is a further specific object of this invention to maximize the
benefits to be derived from tissue hypothermia.
In accordance with these and other objects of the invention, a
thermal transmission medium having one surface of substantially the
same size and shape as the transplanted tissue to be cooled is
placed in substantial contact with the entirety of the transplanted
tissue without any substantial contact with the surrounding tissue.
The cooling face of a thermoelectric device is then placed in
contact with an exposed surface of the thermal transmission medium
to cool the transplanted tissue. A temperature sensing device such
as a thermistor is placed between the transplanted tissue and the
thermal transmission medium and a signal representing the sensed
temperature is applied to the input to the thermostatic control
which maintains the temperature of the transplanted tissue within
the selected 15.degree.-20.degree. C. temperature range.
In accordance with one important aspect of the invention, the
thermal transmission medium may comprise a flexible, liquid-filled
bag. The bag itself may be formed so as to have one surface of the
proper size, shape and outline so as to conform with the
transplanted tissue to be cooled. In this connection, the bag may
be formed from sheets of latex rubber which are adhesively sealed
together over a substantial portion of the periphery thereof,
filled with a liquid such as water, and then sealed shut.
In accordance with another object of the invention, the heat
generated by the thermoelectric device is carried off by a coolant
circulating system. The circulating system comprises a heat
exchanger, a pump and a pressure sensitive switch which is adapted
to interrupt the supply of power to the thermoelectric device when
a pressure drop in the collant circulating system is encountered,
as when the pump fails or the coolant otherwise fails to
circulate.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 illustrates an embodiment of the invention being utilized to
cool a pedicle flap in a laboratory animal;
FIG. 2 is an enlarged perspective view of the pedicle flap being
cooled in FIG. 1 and the cooling mechanism in contact
therewith;
FIGS. 3 (a--f) are simplified perspective views illustrating
various steps in the formation of a water-filled bag which serves
as the thermal transmission medium between the pedicle flap of FIG.
2 and a thermoelectric cooling device;
FIG. 4 is a schematic diagram of the electrical circuitry in a
preferred embodiment of the invention; and
FIG. 5 is a schematic diagram of the hydraulic system in a
preferred embodiment of the invention.
DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT
In accordance with this invention and as depicted in FIG. 1, a
thermoelectric cooling device 10 is being utilized to cool the
pedicle flap of a laboratory rabbit 12 through a thermal
transmission medium comprising a water-filled, latex rubber bag 14.
Since the pedicle flap must be cooled over an extended period of
time, the rabbit 12 is held in a substantially stationary position
by a restraining box 16. Electrical lead lines 18 from temperature
sensing and control devices, e.g., thermisters, and
electrical-hydraulic umbilical lines 20 from the thermoelectric
device 10 extend through an opening 21 in the restraining box 16.
As shown in FIG. 2, the thermisters 2282 a--c are connected to the
electrical leads 18.
In accordance with one very important aspect of the invention shown
in FIG. 2, the water-filled rubber bag 14 has a cooling surface 23
in contact with the pedicle flap 24 which is of substantially the
same size, shape and outline as the pedicle flap 24. By providing
such a cooling surface 23 on the rubber bag 14, a cooling face 26
of the thermoelectric device 12 which is in contact with exposed
surface 27 of the bag 14 is able to cool the pedicle flap 24 alone
without any substantial cooling of the surrounding tissue. This has
been found to be critical if high flap viability is to be
obtained.
In accordance with another important aspect of the invention, the
temperature of the pedicle flap 24 is precisely controlled to
maximize the viability of the pedicle flap. In this connection, the
thermister 22 a is located between and in contact with the flap 24
as well as the bag 14.
It has been found that the temperature of the pedicle flap 24 may
be maintained with a good deal of precision at a preset temperature
level in the range of 15.degree.-20.degree. C. Temperature at the
distal end of the flap stayed, for the most part, within
1.degree.-2.degree. C. of the pre-set temperature. Temperatures
taken at the sides of the flap (anteriorly and posteriorly) were at
times warmer than the pre-set temperature but all peripheral parts
of the flap were always at least 5.degree.-15.degree. C. (generally
10.degree. C.) cooler than the surrounding normal skin
temperatures. Temperatures of the surrounding tissue, as monitored
by the thermistor 22c, remained within 5.degree. of normal skin
temperature. The precision in temperature control is attributed to
the configuration of the bag 14 as well as the precise temperature
control afforded by the thermoelectric device. In addition, it is
believed that the thermal inertia provided by the liquid medium in
the water-filled bag which is separate and apart from any
circulating coolant is of great assistance in maintaining the
proper pedicle flap temperature.
In accordance with another important aspect of the invention, the
heat generated at the hot side 30 of the thermoelectric device 10
is carried away from the pedicle flap 24 by a coolant such as water
which is circulated to and from the hot side 30 of the
thermoelectric device 10 by means of the umbilical lines 20. This
removal of heat from the thermoelectric 26 which is in close
proximity to the patient permits the necessary cool temperatures at
the pedicle flap 24 to be maintained as well as eliminating any
discomfort to the patient due to the heating at the hot side 30.
The nature of the coolant circulating system including the
umbilical lines 20 will be described in somewhat further detail
with reference to FIG. 5.
Referring now to FIGS. 3a--f, a preferred method of forming a
water-filled bag having a cooling surface of the appropriate size,
shape and outline will now be described. As shown in FIG. 3a, a
sheet 40 of latex rubber or other water impervious material is
being cut to form two circular segments 42. Note that the segments
42 which may be first traced on to the sheet 40 using a template
are of the same shape and slightly larger size than the pedicle
flap to be cooled where the dotted circular lines correspond to the
size of the pedicle flap. A scalpel 44 or other suitable cutting
means may be utilized to cut the segments 42 from the sheet 40.
In FIG. 3b, a rubber or dermatome cement is being applied from a
tube 46 to a substantial portion of the peripheries 48 of the
segments 42. Note however that a portion 50 of the periphery of
each of the segments 42 does not receive the cement. In FIG. 3c,
the peripheries 48 of the segments 42 are being secured to one
another by sandwiching the segments 42 between a surface 52 and a
weight 54. After a suitable length of time to assure a good bond
along the peripheries 48 of the segments 42, water may be applied
through a hose 56 or other suitable means, to an opening formed at
peripheral portions 50 of the segments 42 as shown in FIG. 3d. Once
the segments 42 are filled with water, the peripheral portions may
be sealed shut utilizing cement from the tube 46 as shown in FIG.
3e and then brought into bonding relation by a clamp 58 shown in
FIG. 3f to incapsulate the water in the bag 14.
In the electrical schematic diagram of FIG. 4, the thermoelectric
device 10 is supplied by a power pack 60 (This is a simple, open
chasis, center tap transformer-choke-12 automotive-type diode
package with approximately 15 percent ripple at design output)
which is supplied by a 110 volt AC force 62 in series with a
variable transformer 64. A power switch 66 controls the application
of the 110 volts to the power pack 60.
A thermostatic control 68 such as the Yellow Springs Instrument
Temperature Controller, Model 73 or similar controlling unit is
connected in series with the thermoelectric device 10 in response
to the temperature being sensed by the thermister probe 22a.
In order to circulate the coolant through the thermoelectric device
10, a pump 70 is also connected across the 110 volt source 62. A
pressure switch 72, which is responsive to the pressure of the
coolant being pumped by the pump 70 is connected to relay 74 having
a coil 76. When the pressure sensed by the switch 72 is at or above
a predetermined leve, a movable contact bar 78 is in contact with
contact points 80 to provide power from the power pack 60 to the
temperature controller 68 and the thermoelectric device 10.
However, when the pressure sensed by the switch 72 drops below a
predetermined level, the contact between the bar 78 and the point
80 is broken and contact between a coolant bar 82 and contact
points 84 is established so as to apply power from the source 62 to
an indicating light 86 or other suitable alarm means while
interrupting power to the thermoelectric device 10. When the light
86 is on, it may indicate a pump failure which would result in an
increase in the temperature at the cooling face 26 of the
thermoelectric device 10 and a resulting, potentially harmful rise
in the temperature of the pedicle flap 24.
A fan 88 is also connected across the source 62. The fan circulates
the air across the vanes of the heat exchanger. It also assures
proper cooling of the electrical components in the system. An
on/off light 89 is also provided across the source 62 so as to
indicate when the power switch 66 is closed. Fuses 90 are provided
in series with the power switch 66, the pump 70, the fan 88 and the
power pack 60. A volt meter 91 is provided across the output
terminals of the power pack 60 to permit the monitoring of the
input voltage to the thermoelectric device 10.
As mentioned previously, the coolant is circulated through the
thermoelectric device 10 to carry away the heat from the hot face
thereof. As shown in FIG. 5, the coolant is circulated by the pump
70 through the pressure switch 72 and into and out of the
thermoelectric device 10. Coolant then flows to a heat exchanger 92
and into a coolant reservoir 94. The coolant may comprise water or
other suitable liquid coolants.
Various thermoelectric devices may be utilized in this system. As
utilized herein, the term "thermoelectric device" embraces any and
all devices which utilize the Peltier Effect involving the
generation of or obstruction of heat (depending upon the direction
of current) at a rate Q, at the junction between two different
semiconductors when a current I flows through the semiconductors.
The rate Q equals II .times. I where II is the Peltier coefficient
which is a function of semiconductor conductivities.
One particularly satisfactory thermoelectric device is the model
no. CP 1.4-71-06 manufactured by the Melcor Corporation, 990 Spruce
Street, Trenton, N.J. This device has a cooling face of 1.17 square
inches which is capable of 102 BTU's per hour with a maximum
current of 6 amps. The device includes a coolant circulating path
associated with the warm face of the device. This particular size
thermoelectric device is particularly suitable for use with a
pedicle flap of 3+ square inches. In general, it is desirable and
preferred to utilize a thermoelectric device having a cooling face
with area which is equal to at least 10 percent of the pedicle flap
area and preferably 33 percent or more. This of course means that
the thermoelectric device cooling face is equal to at least 10
percent and preferably 33 percent or more of the cooling surface of
the rubber, water-filled bag in contact with the pedicle flap.
Experiments conducted on pedicle flaps which were not cooled and
those which were cooled with the previously described system of
this invention indicate that the latter have greatly improved
chances of survival as compared with the former. Without cooling,
slough of the uncooled flaps was evident by the end of the first
day and well-established by the end of the third day. In contrast,
the flaps which were cooled with the system of this invention were
for the most part healthy afer 7 days. Without cooling, the
estimated survival of viability of the flaps was 20 percent as
compared with 643 percent for the flaps cooled in accordance with
this invention. The survival or viability of the flaps cooled with
the invention would have been higher except for the loss of one
flap. If it were not for the loss of this one flap, final estimates
of viability would have increased 75 percent in the cooled flaps.
It has also been found that the viability of the flaps is
dramatically reduced if the surrounding tissue is cooled or the
temperature of the tissue is allowed to fluctuate as by spacing the
control thermister from the tissue to be cooled.
Although the system has been described in conjunction with the
cooling of pedicle flaps, it is understood that it is equally
applicable to the cooling of grafts and other tissue transplants in
situ also. Even though a particular embodiment of the invention has
been shown and described in detail, it will be understood that
various modifications will occur to those of ordinary skill in the
art which fall within the true spirit and scope of the invention as
set forth in the appended claims.
* * * * *