U.S. patent number 3,837,341 [Application Number 05/390,739] was granted by the patent office on 1974-09-24 for medicament inhalation device with audible indicating means.
This patent grant is currently assigned to Fisons Limited. Invention is credited to John Howard Bell.
United States Patent |
3,837,341 |
Bell |
September 24, 1974 |
MEDICAMENT INHALATION DEVICE WITH AUDIBLE INDICATING MEANS
Abstract
There is described an inhalation device, which is adapted to
administer a medicament to the lungs and to be activated by the
inspiration of the user, in combination with means adapted to
indicate audibly when a desired air flow through the device is
achieved.
Inventors: |
Bell; John Howard
(Loughborough, EN) |
Assignee: |
Fisons Limited (London,
EN)
|
Family
ID: |
10408084 |
Appl.
No.: |
05/390,739 |
Filed: |
August 23, 1973 |
Foreign Application Priority Data
|
|
|
|
|
Aug 23, 1972 [GB] |
|
|
39173/72 |
|
Current U.S.
Class: |
128/203.15;
128/203.21 |
Current CPC
Class: |
A61M
15/0033 (20140204); A61M 15/0028 (20130101); A61B
5/087 (20130101); A61M 2205/43 (20130101); A61M
2202/064 (20130101) |
Current International
Class: |
A61B
5/08 (20060101); A61B 5/087 (20060101); A61M
15/00 (20060101); A61m 015/06 () |
Field of
Search: |
;128/206,208,266 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Medbery; Aldrich F.
Attorney, Agent or Firm: Wenderoth, Lind & Ponack
Claims
I claim
1. An inhalation device, for administering and dispensing a
medicament to the lungs comprising a movable means activated by the
air inspiration of the user, in combination with a means for
indicating the operation of the device comprising an audible means
operated by said inspired air when a desired air flow through the
device is achieved.
2. A device according to claim 1, wherein the device has a means
for administering a powdered medicament.
3. A device according to claim 1, further comprising a hollow
elongate housing having at both ends thereof an air passageway and
having one end adapted for insertion into the mouth; and said
movable means comprises a propeller-like member rotatably mounted
in the housing on a rigid shaft mounted in the housing and coaxial
with the longitudinal axis of the housing, said propeller-like
device having on the part thereof furthest from the end of the
housing adapted for insertion into the mouth, mounting means
adapted to receive a container, such as a gelatine or like capsule
for the medicament to be inhaled and said propeller-like device
being so mounted on said shaft that the passage of a stream of air
through the device causes not only rotational movement of the
propeller-like device, but also a vibrational movement of the
propeller-like device.
4. A device according to claim 1, wherein said audible means is an
acoustic whistle.
5. A device according to claim 1, wherein said audible means is a
siren.
6. A device according to claim 4, wherein the acoustic whistle has
an edge-type tone generator.
7. A device according to claim 4, wherein said acoustic whistle is
a hole-type tone generator.
8. A device according to claim 1, wherein said audible means is a
double orifice whistle.
9. A device according to claim 1, wherein said audible means
includes means operable to produce a change from not sounding to
sounding.
10. A device according to claim 1, wherein said audible means is
operable when the user inhales through the device, but not when the
user exhales through the device.
11. A device according to claim 1, wherein said audible means is a
propeller-like device in which the blades are designed to emit a
noise when reaching a given speed.
12. A device according to claim 7 wherein said acoustic whistle is
a ring-type tone generator.
Description
BACKGROUND OF THE INVENTION
This invention relates to a new form of device for the inhalation
of medicaments and the like.
In British Patent Specifications Nos. 1,122,284 and 1,182,779 there
are described devices for the inhalation of medicaments in finely
divided form, which comprise a hollow elongate housing having at
both ends thereof an air passageway and having one end adapted for
insertion into the mouth; and a propeller-like member rotatably
mounted in the housing on a rigid shaft mounted in the housing and
coaxial with the longitudinal axis of the housing, said
propeller-like device having on the part thereof furthest from the
end of the housing adapted for insertion into the mouth, mounting
means adapted to receive a container, such as a gelatine or like
capsule for the medicament to be inhaled and said propeller-like
device being so mounted on said shaft that the passage of a stream
of air through the device causes not only rotational movement of
the propeller-like device, but also a vibrational movement of the
propeller-like device. The device may be provided with means for
piercing the container in situ in the device.
A number of other devices are also known and used for the
inhalation of powder and other medicaments, and a number of these
devices also depend upon the inspirational power of the user to
actuate them or to disperse the medicament into the air stream to
be inhaled (see for example Belgium Pat. No. 781,102 in which there
is described a device comprising a chamber in which a perforated
capsule containing a powdered medicament can be freely tumbled by
tangential jets of incoming air and the air into which the
medicament is dispersed passes from the chamber to the inhalers
mouth). Indeed in certain devices and using certain medicament
formulations it is desirable that a given minimum air speed be
achieved (or maximum air speed avoided) to produce a satisfactory
operation of the device (e.g. dispersion of the medicament). In
some instances notably with children and old people, it can be
difficult to teach the user to inhale in such a manner as to
operate the device satisfactorily. Furthermore inhalation devices
are often used by people who have reduced inspiratory power, e.g.
those suffering from respiratory diseases, and children. Therefore
when people having reduced inspiratory power use inhalation devices
it is not always possible to determine whether the flow of air
through the device has been sufficient to actuate the device
satisfactorily. Thus some such users may be receiving variable or
insufficient medication.
SUMMARY OF THE INVENTION
According to our invention we provide an inhalation device, which
is adapted to administer a medicament to the lungs and to be
activated by the inspiration of the user, in combination with means
adapted to indicate audibly when a desired air flow through the
device is achieved.
The inhalation device may be any of those conventionally used, but
is preferably a device which is designed to administer a powdered
medicament, e.g. the device described in either of British Patent
Specifications Nos. 1,122,284 or 1,182,779.
The means adapted to indicate audibly when the desired air flow
through the device (indicating means) is achieved may be, for
example a whistle (Robert C Chanaud, Scientific American, January
1970 pages 40 to 46), such as an aerodynamic whistle. Aerodynamic
whistles may be roughly classified into three groups (a)
hydrodynamic whistles, (b) acoustic whistles and (c) reflected
whistles. Many conventional whistles combine characteristics of
more than one of these groups. As hydrodynamic whistles there may
be mentioned aeolian tone generators (e.g. a thin cylinder placed
in an air stream), and vortex whistles in which latter a swirling
flow of air encounters the open end of a pipe. Acoustic whistles
include those generated by the impingement of a jet of air on an
edge, a ring or a hole to produce respectively an edge tone, a ring
tone or a hole tone. We particularly prefer to use a hole tone
generated by the passage of air through a double orifice hole with
an intervening chamber, as in the whistle of a whistling kettle.
Acoustic whistles comprise those in which a resonant or reflecting
structure is involved, as in a flute or organ pipe. For the
purposes of the present invention an acoustic whistle similar to
the type used by English policemen (simple flute type) or by
American policement (comprising a solid object, e.g. a pea or the
like, loosely trapped in a sounding chamber) may be used. A reed
whistle may also be used. Other indicating means include a
propeller like device in which the blades are designed to emit a
noise on reaching a given speed; or may be a siren. Any of the
above indicating means may be used in conjunction with an air
by-pass, the air by-pass being of such a size that the indicating
means will only commence to sound or will change the sound at the
desired air-flow rate.
The indicating means may be such that the sound emitted changes at
more than one rate of air flow through the device. Thus the
indicating means may be adapted to indicate a minimum and a maximum
desirable air flow, or a minimum and a desirable average air
flow.
The change of sound should be such as to be easily noticed and may
be, for example a change of volume, pitch, quality, frequency, tone
etc. We prefer the change to be from not sounding to sounding, or
vice versa.
We prefer that the indicating means should be actuatable when the
user inhales through the device, but not when the user exhales
through the device.
The indicating means may be made integrally with the inhalation
device, or may be made separately, the two parts being made in such
a way that they may be fitted together, for example by a screw
thread, a bayonet fit or a simple push fit.
The indicating means may be positioned downstream of the point at
which medicament is dispersed into the air stream, but, in order to
avoid contamination of the indicating means, it is preferably
positioned upstream of this point, e.g. at the point of entry of
the air stream into the device.
The device according to the invention is particularly useful when
it incorporates an inhalation device as described in British Patent
Specification No. 1,182,779 and is used to disperse a powder
composition as described in British Patent Specification No.
1,242,211, i.e., a mixture of a solid finely divided medicament
having a particle size in the range 0.01 to 10 microns and a solid
pharmaceutically acceptable water soluble carrier having an
effective particle size in the range 30 to 80 microns, e.g. a
mixture of fine particles of sodium cromoglycate and coarse
particles of lactose.
The indicating means may be made of any suitable material, for
example metal or plastics materials, e.g. PVC, polypropylene,
polyethylene or nylon.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention is illustrated by the attached drawing, which is not
to scale and in which FIG. 1 is a longitudinal section through a
device according to the invention, which incorporates a device
according to British Patent Specification No. 1,182,779.
DETAILED DESCRIPTION OF THE INVENTION
In FIG. 1 an inhalation degice comprises a housing of approximately
circular cross-section comprising two engaging housing members 6
and 7, housing member 7 being adapted for insertion into the mouth
and having passageways 8 therein to permit the passage of air.
Mounted rigidly in and co-axially with housing member 7 is shaft 2
upon which is loosely and rotatebly mounted by means of bearing 17
propeller-like member 3 having blades 4.
Propeller-like member 3 has a cup shaped member adapted to receive
and hold a capsule or container 5 of finely powdered
medicament.
Shaft 2 engages in bearing 17 on propeller-like member 3. The
diameter at the inner end of bearing 17 is about 3.75 percent
greater than the diameter of shaft 2 and the diameter at the outer
end of bearing 17 is equal to the diameter of shaft 2 plus about
2.5 percent of the total length of the bearing, which is about 7
times the diameter of shaft 2.
Housing member 6 has in its end wall air passages 9 to permit the
passage of air. Housing 6 is firmly attached to body member 1, for
example it may be glued thereto, and mouthpiece 7 is removably
attached to body member 1 by means of co-operating screw threads 34
in body member 1 and mouthpiece 7.
Housing member 6 has a central projection 25 with a slot in which
is mounted resilient piercing member 26. Piercing member 26 is
retained in the slot in projection 25 by means of retaining block
27 which is, in turn, held in position in the slot by means of pin
28. The arms of resilient piercing member 26 are located in slots
in the walls of body member 1 and in guideways formed by guide
members (not shown) extending inwardly from the inner surface of
body member 1.
Slidably mounted on body member 1 is tubular member 30 having
cam-like projections 31 extending inwardly through the slots in
body member 1. When member 30 is slid downwards from the position
shown in FIG. 1 cam-like projections 31 engage with the arms of
resilient piercing member 26 to force them inwards and thus to
force piercing projections 32 into contact with the surface of
capsule 5 and finally to pierce capsule 5, the depth of piercing
being limited by stops 33. When the member 30 is slid back to the
position shown in FIG. 1 the resilience of member 26 causes the
arms to spring apart and to resume the position shown in FIG.
1.
Mounted on housing member 6 by means of a push fit is a double
orifice whistle 41 comprising a first orifice plate 35 having
central orifice 36, a second orifice plate 37 having a central
orifice 38, a primary sound chamber 39 and a secondary sound
chamber 40.
In operation, the device is first loaded with capsule 5 by
unscrewing mouthpiece 7 from body member 1 and placing capsule 5 in
the cup-like depression in propeller-like device 3. Mouthpiece 7 is
then screwed back into body member 1, and capsule 5 pierced by
sliding member 30 downwards from the position shown in FIG. 1 and
then back to the position shown in FIG. 1.
The user then places mouthpiece 7 in the mouth and inhales through
the device causing rotation and vibration of the propeller-like
member 3, (and, when the desired air speed is achieved causing the
whistle 41 to sound) thus administering powdered medicament
contained in capsule 5.
* * * * *