U.S. patent number 3,836,329 [Application Number 05/191,889] was granted by the patent office on 1974-09-17 for method and apparatus for removing liquid from containers.
This patent grant is currently assigned to Damon Corporation. Invention is credited to Michael Jordan.
United States Patent |
3,836,329 |
Jordan |
September 17, 1974 |
**Please see images for:
( Certificate of Correction ) ** |
METHOD AND APPARATUS FOR REMOVING LIQUID FROM CONTAINERS
Abstract
An apparatus for removing a liquid from a container such as a
test tube comprising a probe having a diameter slightly smaller
than the container inside diameter. The probe has a bore connected
to a source of gas at a superatmospheric or subatmospheric pressure
which effects a gas flow between the probe and container to entrain
liquid from the container into the gas stream.
Inventors: |
Jordan; Michael (South
Merrimack, NH) |
Assignee: |
Damon Corporation (Needham
Heights, MA)
|
Family
ID: |
22707316 |
Appl.
No.: |
05/191,889 |
Filed: |
October 22, 1971 |
Current U.S.
Class: |
436/49; 134/21;
134/24; 141/130; 73/864.01; 134/22.11; 134/37; 134/22.12; 422/549;
422/562 |
Current CPC
Class: |
G01N
35/1095 (20130101); Y10T 436/114998 (20150115) |
Current International
Class: |
G01N
1/00 (20060101); B08b 005/04 (); B08b 009/00 ();
G01n 031/00 () |
Field of
Search: |
;23/23R,253R,259,292
;73/423A ;134/21,22R,22C,24,37 ;141/130 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Scovronek; Joseph
Attorney, Agent or Firm: Kenway & Jenney
Claims
I claim:
1. The method of removing residual liquid from a container which
comprises placing a probe adjacent the bottom inside surface of
said container, said probe having an outside diameter slightly
smaller than the inside diameter of the container, said probe
having a bore extending between its top and bottom surfaces, and
said bore being connected to a source of gaseous fluid, aspirating
fluid through said bore to entrain any liquid in the container into
said bore, removing said probe from said container, placing a
second probe adjacent the bottom inside surface of said container,
said second probe having an outside diameter slightly smaller than
the inside diameter of the container, said second probe having a
central bore extending between its top and bottom surfaces and
having at least one side bore extending between the central bore
and a side wall of said probe, said central bore in said second
probe being connected to a source of gaseous fluid, and forcing
such fluid through the bores in said second probe successively into
said container and outward from a top opening in said
container.
2. The process of claim 1 wherein such gaseous fluid is forced
through said second probe while said second probe is moved from the
bottom inside surface of said container and outward through the top
opening in said container.
3. In automated analysis apparatus which repeatedly delivers a
quantity of liquid material to at least one container having an
open end opposite a closed end, and having means for flushing said
container with wash liquid and for emptying said container thereof
intermediate the delivery of successive quantities of said liquid
material thereto, the improvement comprising
a probe having a free end and arranged for extension into, and
subsequent retraction from, said container intermediate said
flushing and said delivery of liquid material to the container,
said probe having a first portion adjacent said free end therrof
for disposition when said probe is so extended within said
container adjacent the container closed end,
said probe further having port means in said first portion and
having a fluid passage therein communicating with said port means
and for connection to gas pressure source means for producing, via
said fluid passage and said port means, a gas stream within said
container and through said container open end and including through
the annular space between the container inner surface and said
probe portion, and
means on said probe portion enlarging the size thereof for
constricting said annular space for thereby causing said gas stream
to pass said constricted space with a wiping action against the
container inner surface.
4. In automated apparatus as defined in claim 3 the further
improvement wherein said container has a substantially circular
interior cross section of uniform inside diameter, and said
enlarging means provides said probe portion with a circular cross
section having an outside diameter only slightly smaller than said
inside diameter of the container.
5. In automated apparatus as defined in claim 3, the further
improvement wherein
said probe has a further portion thereon spaced from said free end
and said port means and of significantly lesser cross-sectional
size than the cross-sectional size of said enlarging means, and
said enlarging means provides said probe first portion with a
sufficiently large cross-sectional size relative to said container
to produce a substantial pressure drop in said gas stream between
said port means and said second portion.
6. In automated apparatus as defined in claim 3 the further
improvement wherein said probe first portion
has an inner end removed from said probe end and of substantially
lesser cross-sectional size than said enlarging means, and
has a convexly rounded surface between said inner end thereof and
said enlarging means.
7. In automated apparatus as defined in claim 3 the further
improvement comprising gas pressure source means connected with
said fluid passage of said probe and producing a gas stream that
exits from said fluid passage at said port means for passage
through said constricted annular space and outward from said
container through said open end thereof.
8. In automated apparatus as defined in claim 3 the further
improvement comprising gas pressure source means connected with
said passage of said probe and drawing said gas stream into said
passage via said port means for drawing said gas stream into said
container through said open end thereof and through said
constricted annular space.
9. In automated apparatus as defined in claim 3 the further
improvement wherein said probe first portion has an end surface
contoured substantially like the contour of said container closed
end.
10. In automated apparatus as defined in claim 3 the further
improvement wherein said port means includes at least a port at the
extreme free end of said probe first portion.
11. In automated apparatus as defined in claim 3 the further
improvement wherein said port means includes a plurality of side
ports passing through sidewalls of said probe first portion and
communicating with said fluid passage.
12. In automated apparatus as defined in claim 3 the further
improvement wherein said fluid passage extends along a first axis
within said probe and
said port means includes an end port in line with said passage and
a plurality of side ports extending transversely from said passage
and exiting from said probe first portion along the sides
thereof.
13. In automated apparatus as defined in claim 3 the further
improvement comprising
means for selectively and alternately extending said probe into
said container and withdrawing said probe from said container.
14. Clinical analysis apparatus for removing liquid residue from a
container of selected interior cross section and having an open end
opposite a closed end, said apparatus comprising
probe means
arranged for repeated extension into, and retraction from, said
container through said open end thereof and without closing said
open end,
having a free end arranged for disposition adjacent said container
closed end when said probe means is extended into said container,
and
having at least one port and having a fluid passage communicating
with said port,
a source of gas pressure connected with said probe passage for
producing, by way of said passage and port and when said port is
within said container, a gas stream within said container and
passing through said open end thereof, and
an enlarged end portion on said probe at said free end and through
which said port is exposed, said enlarged portion having a
cross-sectional size that is larger than elsewhere on said probe
within said container when extended, and is sufficiently large
relative to the interior cross-section of said container to
constrain said gas stream to pass therearound with a wiping action
on the container inner surface.
15. In the automated analysis of liquid material, an improvement in
the process of removing such liquid from a container having a
closed end opposite an open end and which repeatedly receives a
quantity of the liquid material, said improvement comprising the
successive steps of
introducing a gas stream into said container through said open end
thereof and via a passage removably and replaceably extending into
said container to adjacent said closed end thereof, and
constraining said gas stream to pass contiguously along the
container inner surface through an annular space of small
cross-sectional area relative to the cross-sectional area of said
container, so that said gas stream removes liquid from the
container inner surface.
16. In the automated treatment of liquid material, an improvement
in the process of removing such liquid from a container having a
closed end opposite an open end and which repeatedly receives a
quantity of the liquid material, said improvement comprising the
successive steps of
providing a passage-forming probe removably and replaceably
extending into said container through said open end thereof with
the passage end adjacent said container closed end, said probe
having on at least a portion thereof an enlargement of the outer
surface sufficient to leave only a space which is small relative to
said container between said probe outer surface and said
container,
introducing a gas stream into said container by means of said probe
passage, and
constraining said gas stream to pass through said small space
contiguous with said container inner surface, thereby to produce
with said gas stream a wiping action of such fluid material from
the container inner surface.
17. In a process as defined in claim 16, the further improvement
comprising the steps of
gradually withdrawing said probe from said container, and
maintaining said gas stream through said passage during the
withdrawal of said probe from said container.
18. In a process as defined in claim 16, the further improvement
wherein said gas stream introducing step discharges gas into said
container from said probe passage.
19. In a process as defined in claim 16, the further improvement
comprising the steps of
moving said probe relative to said container to move said large
probe surface between said container ends, and
maintaining said gas stream during said relative movement, thereby
to constrain said gas stream to pass contiguous with said container
inner surface along the length thereof between said container ends.
Description
This invention relates to a method and apparatus for removing
liquids from containers particularly containers which must be
cleaned repeatedly.
In some present automatic constituent analyzers of liquids, an
aliquot is introduced into a container, such as a test tube,
reacted therein and then removed therefrom for analysis to
determine the degree of reaction. Prior to introducing the next
successive aliquot, the container must be rendered free of any
remaining liquid to prevent the contamination of the incoming
aliquot. At the present time, the most common method employed
involves aspirating the fluid by means of a hollow probe having a
substantially smaller diameter than the container, introducing wash
liquid into the container and then aspirating the wash liquid from
the container with the same size probe. Since the wetting of the
container wall generally is non-uniform, residual liquid remains
thereon after aspiration. Thus, this method is undesirable since
the removal of liquid from the walls and bottom of the container is
incomplete. It has been proposed also to provide additional
subsequent steps of introducing desiccated or heated gas such as
air into the container after the wash fluid has been removed
thereby to effect the desired liquid removal. However, the use of
desiccated or heated air is expensive by virtue of the desiccated
cost or heat control cost and therefore in most cases this solution
is impractical. More importantly, removing the water from the
vessel by evaporation may not produce the desired cleanliness since
the contaminants dissolved in the water will not evaporate and will
remain behind.
The present invention is based upon the discovery that a container,
as for example a test tube, can be rendered free of liquid by
employing a probe, the bottom end of which has a diameter only
slightly smaller than the inside diameter of the container and
having ports for passing fluids therethrough. In one aspect of the
present invention, the enlarged portion of the probe has a port on
the bottom surface thereof so that when inserted in the container,
the port is adjacent the bottom surface of the container. In this
aspect, a vacuum is applied to the probe chamber so that liquid in
the container can be aspirated through the probe and out of the
container. In another aspect of the present invention, the probe
can also be provided with ports on the side walls, at a vertically
intermediate height of the enlarged portion, to pass gas under
pressure into the container. In the latter case, blowing is
continued while withdrawing the probe from the container so that
any liquid therein precedes the probe and exits from the top of the
container.
It has been found that by employing the probe of this invention,
substantial pressure drops can be generated between the top of the
probe portion having the enlarged diameter and the fluid port or
ports so that all of the liquid on the walls and on the bottom of
the container can be entrained in the moving gas stream generated
either through the probe or by being forced out of the top of the
container. It is preferred that the top of the probe portion having
the large diameter be convex to eliminate sharp edges which might
damage the containers and to effectively maintain the pressure drop
generated between the probe port or ports and the top surface of
the enlarged portion of the probe.
This invention will be more fully understood with reference to the
accompanying figures.
FIG. 1 is an isometric view, in partial cross-section, of a portion
of a fluid analysis system in which test tubes periodically
received liquids and periodically are cleaned.
FIG. 2 is a side view, in partial cross-section, of the system of
FIG. 1 wherein the probes of this invention are located in the
bottom of test tubes.
FIG. 3 is a side view, in partial cross-section, of the system of
FIG. 1 while the probes are being withdrawn from the test
tubes.
FIG. 4 is a cross-sectional view of a probe with side ports taken
along the line 4--4 of FIG. 3.
FIG. 5 is a cross-sectional view of a probe taken along the line
5--5 of FIG. 3.
The fluid analysis system shown in FIG. 1, wherein aliquots of
fluid are continually tested for various substituents and the
containers in which the chemical reactions occur are continually
cleaned, is more fully described in the commonly assigned copending
application entitled "Constituents-Measuring Chemical Analyzer
Having Sample Processing Conduit Feeding Aliquot-Processing
Conveyor System" by David I. Kosowsky, Andres Ferrari and Carl R.
Hurtig and filed concurrently herewith, i.e. on Oct. 22, 1971 and
bearing Ser. No. 191,884, now U.S. Pat. No. 3,764,286, issued Oct.
9, 1973. The system for delivering and removing fluids from test
tubes comprises a top tray 1 adapted to move vertically by vertical
drive means (not shown) and having probes for delivering or
removing liquids to or from test tubes retained in bottom tray 2.
As shown in FIG. 1, the tray 1 is slightly thicker at the portion
thereof employing larger probes extending to the bottom inside
surface of the test tubes to improve axial stability of these
probes when they register in the test tubes. The tray 1 is provided
with a plurality of holes through its thickness to accommodate
probes that extend through and beyond the thickness of the tray 2
and suitable connections for distributing samples, reagents and
washing fluid as well as for delivering air or removing air for
purposes of cleaning the test tubes in tray 2. In the system, all
fluids are introduced into the test tubes located in tray 2 when
tray 1 is moved vertically downward so that the probes in the
various positions register within the tubes.
By way of example, samples are introduced into two test tubes in
tray 2 through conduits 3 and 4 and probes 5 and 6 extending from
probe holders 7 and 8. After the sample has been introduced into
the two test tubes, tray 1 is elevated relative to tray 2 to the
position shown in FIG. 1 and tray 2, having rotational drive means
(not shown), is indexed counterclockwise to register the two tubes
beneath reagent probes 11 and 12 connected with conduits 9 and 10.
Tray 1 is then moved vertically toward tray 2 so that the reagent
can be introduced through conduits 9 and 10 into the two test tubes
on tray 2 into which the probes 11 and 12 extend. The vertical
movement of tray 1 and the indexing of tray 2 counterclockwise is
repeated until the two test tubes containing the reacted
sample-reagent mixture are located beneath probe holders 14 and 15.
Each probe holder 14 and 15 has three probes associated therewith,
each connected to a conduit for passing fluids. Conduits 16 and 17
are connected to a source of vacuum, illustrated as the vacuum
section 60a of a pressure source 60, and to probes, of which the
one probe 19 connected to conduit 17 is shown, so that the
serum-reagent mixture is aspirated via these probes through
conduits 16 and 17 into a means for determining the extent of
reaction, such as a colorimeter (not shown). After the
sample-reagent mixture has been aspirated, trays 1 and 2 remain
juxtaposed and wash fluid is introduced through conduits 20 and 21
and through probes, of which the one probe 22 connected to conduit
21 is shown, to preliminary clean the two test tubes, as shown in
FIG. 2 for the one test tube 19a. Conduits 24 and 25 are connected
to a source of vacuum and to probes, of which the one probe 26
connected to conduit 25 is shown, that extend a short vertical
distance within the test tube so that wash fluid introduced through
the latter two probes will not overflow onto tray 2 but rather will
be aspirated through these probes. Thereafter, wash fluid is
aspirated to the colorimeter via the probes connected to conduits
16 and 17.
Tray 1 then is moved vertically upward and tray 2 is indexed
counterclockwise so that the two test tubes now designated 29a and
30a, register with probes 29 and 30 connected to conduits 31 and 32
through which is introduced excess water. As the tray 2 is rotated,
the test tubes contact heated liquid in troughs 36 and 36a which
are maintained at different temperatures depending upon the type of
reaction being carried out at the radial position corresponding to
troughs 36 and 36a. Sufficient wash water is introduced through
probes 29 and 30 so that the wash water in the test tubes will
overflow the test tube onto tray 2 and be confined by walls 33 and
34 to flow into trough 35. All of the test tubes are maintained
above the surface of tray 2 by walls 13 so that no liquid will flow
into the test tubes from the tray surface. The test tubes filled
with water then are indexed to register beneath probes 37 and 38
which are connected to a source of vacuum through conduits 39 and
40 to aspirate the water from the test tubes 37a and 38a. Since the
probes 37 and 38 have substantially smaller diameters than the test
tubes, all of the water in the test tubes 37a and 38a is not
aspirated.
The operation of the probes of this invention will be described
with reference to FIGS. 2 and 3. When trays 1 and 2 are juxtaposed,
probes 41 and 42, having enlarged end portions 43 and 44 extend to
the bottom of test tubes 41a and 42a. Conduits 45 and 46 are
connected to a source of vacuum and to probes 41 and 42. During
aspiration, through probes 41 and 42 and openings 47 and 48, air is
caused to move downwardly through the test tubes 41a and 42a and
into the small volume between the test tube inner surfaces and the
outer surfaces of the probe extensions 43 and 44, thereby effecting
a relatively large pressure drop between the top of the probe
extensions 43 and 44 and the probe openings 47 and 48. Thus, any
water in the small volume or adjacent the probe extensions 43 and
44 will be entrained by the moving air into openings 47 and 48. The
test tubes are retained in positions during entry and removal of
the enlarged probe extension by means of tight fitting "0" rings
49.
As shown in FIG. 3, when trays 1 and 2 are moved apart, air is
blown under pressure e.g. from the pressure section 60b of air
source 60 (FIG. 1) through conduits 50 and 51 into probes 52 and 53
and is caused to move through bottom ports 55 and 56 and side ports
57 so that when tray 1 is moved vertically upward, air passing
between the outer surface of probe extensions 58 and 59, and the
inner surface of the test tubes 52a and 53a, causes any entrained
liquid to pass before the moving probes 58 and 59 upwardly and out
of the test tubes 52a and 53a.
As shown in FIG. 4, the probes employed when blowing air into test
tubes having a plurality of side ports 57 and a central bore 55
thereby causing the largest volume of air to pass through side
ports 57 and upwardly through the tube during withdrawal of the
probe 52 from the test tube 52a.
It has been found that the use of probes having a size only
slightly smaller than the container that all of the liquid can be
removed therefrom. Thus, it is not necessary to employ both of the
larger size probes as shown in the figures.
Summarizing the foregoing description and the drawings, this
invention thus provides an improvement for automated apparatus
having at least one container with a closed end opposite an open
end and which repeatedly receives a quantity of liquid material.
The apparatus further has means for flushing the container with
wash liquid and for emptying the container of the wash liquid,
intermediate the delivery of successive quantities of the liquid
material to the container. The improvement is in a probe having a
fluid passage therein and arranged on such apparatus for extension
into the container with the probe free end adjacent the container
closed end. In particular, the improvement is to provide the probe
with at least the portion at its free end contoured substantially
to fill the cross section of the container. This large portion of
the probe causes a fluid stream delivered to the probe from an
external source to pass between the probe portion and the container
inner wall with a wiping action. The outer end of the probe portion
preferably is further contoured, as FIGS. 2 and 3 illustrate, to
conform relatively closely with the closed end of the
container.
The source of the fluid stream is a gaseous pressure source
connected with the probe for creating the fluid stream as a gas
stream. Where the gas stream is drawn into the probe, the aforesaid
wiping action picks up fluid material from the container inner
surface and removes it from the container by way of the probe.
Where the gas stream is directed into the container from the probe,
the wiping action removes fluid material from the container upward
beyond the large probe portion toward the container open top for
discharge therethrough from the container. With either or both of
these arrangements, the wiping action which the invention provides
removes residual fluidic particles from the container prior to the
delivery of another quantity of liquid to it.
* * * * *