U.S. patent number 3,835,835 [Application Number 05/304,563] was granted by the patent office on 1974-09-17 for two compartment locking sampling syringe.
This patent grant is currently assigned to Richardson-Merrell Inc.. Invention is credited to Robert D. MacKenzie, Ronald J. Thompson.
United States Patent |
3,835,835 |
Thompson , et al. |
September 17, 1974 |
TWO COMPARTMENT LOCKING SAMPLING SYRINGE
Abstract
A multi-barrel syringe for drawing blood from a vein which is
characterized by having a plunger member, an intermediate
plunger-barrel member, an outer barrel member and releasable
locking mechanism to fix the intermediate plunger-barrel to the
outer barrel and to release the two members from their fixed
relationship on predetermined movement of the plunger member while
at the same time fixing the said intermediate plunger-barrel to
said plunger whereby the intermediate member acts as a plunger and
causes formation of a chamber for receiving blood between said
outer barrel and said intermediate plunger-barrel member as the
plunger member is withdrawn.
Inventors: |
Thompson; Ronald J. (Lexington,
KY), MacKenzie; Robert D. (Cincinnati, OH) |
Assignee: |
Richardson-Merrell Inc. (New
York, NY)
|
Family
ID: |
23177042 |
Appl.
No.: |
05/304,563 |
Filed: |
November 7, 1972 |
Current U.S.
Class: |
600/575; 604/191;
600/578; 604/218 |
Current CPC
Class: |
A61B
5/153 (20130101); A61M 5/315 (20130101); A61B
5/150755 (20130101); A61B 5/15003 (20130101); A61B
5/150503 (20130101); A61B 5/150389 (20130101); A61B
5/150236 (20130101); A61B 5/150251 (20130101); A61B
5/150244 (20130101); A61M 2005/31598 (20130101); A61B
5/150259 (20130101); A61M 5/31505 (20130101); A61M
2005/31508 (20130101) |
Current International
Class: |
A61B
5/15 (20060101); A61M 5/315 (20060101); A61b
005/14 (); A61m 005/22 () |
Field of
Search: |
;128/DIG.5,218R,218A,218F,276,218M,218C,218PA,218P,220,2F,234-238
;222/136,137,153,386 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
|
|
|
|
|
|
|
2,007,311 |
|
Jan 1970 |
|
FR |
|
1,053,143 |
|
Mar 1959 |
|
DT |
|
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: McGowan; J. C.
Attorney, Agent or Firm: Hattan; L. Ruth Retter; Eugene O.
Rauchfuss, Jr.; George W.
Claims
We claim:
1. A multi-barrel two-compartment syringe for withdrawing blood
from a vein whereby the first drawn blood is introduced into one
compartment, and subsequently withdrawn blood is introduced into a
second compartment without mixing the two samples which
comprise:
a. an innermost plunger member,
b. an intermediate barrel member, and
c. an outer barrel member, the said three members being in
telescopic relationship and being independently movable along their
mutual axis to form two separate compartments, a fitment on one end
of the outer barrel for holding a hollow needle and having a
channel for blood, a channel in one end of said intermediate barrel
co-axially aligned with the channel in the fitment of the outer
barrel member permitting blood to flow into said intermediate
barrel member when the members having the two channels are in
abutment, means on said intermediate barrel member for fixing the
outer barrel member to the said intermediate barrel member to
prevent axial movement with respect thereto, said means further
comprising means releasing said outer barrel from said intermediate
barrel member on predetermined axial movement of said plunger
member and simultaneously fixing said plunger member to said
intermediate barrel whereby said intermediate barrel is withdrawn
from said outer barrel member and a compartment for holding blood
is thus formed between the said outer barrel member and the
intermediate member on continued withdrawal of the plunger.
2. A syringe in accordance with claim 1 in which the lowermost part
of the intermediate barrel member has a downwardly extending tip
with a channel, said tip fitting into a recess in the bottom of
said outer barrel thus providing a compartment between the said
outer and intermediate barrel members.
3. A multi-barrel two-compartment syringe for withdrawing blood
from a vein whereby the first drawn blood is introduced into one
compartment, and subsequently withdrawn blood is introduced into a
second compartment without mixing the two samples which
comprises:
a. an innermost plunger member,
b. an intermediate barrel member, and
c. an outer barrel member,
the said three members being in telescopic relationship and being
independently movable along their mutual axis to form two separate
compartments, a fitment on one end of the outer barrel for holding
a hollow needle and having a channel for blood, a channel in one
end of said intermediate barrel co-axially aligned with the channel
in the fitment of the outer barrel member permitting blood to flow
into said intermediate barrel member when the members having the
two channels are in abutment, holding means on the intermediate
barrel member to carry a locking means, locking means comprising a
lever arm pivoted on said holding means with studs on each end,
means on the outer barrel to engage a stud on the lower end of said
lever arm and hold the intermediate barrel and outer barrel in
fixed relationship, means on the innermost plunger for engaging a
stud on the upper end of said lever arm, means tending to hold the
stud on the upper end of the lever arm against the surface of the
plunger and force the said stud into fixed engagement with engaging
means on the innermost plunger when the relative position of the
two members permits.
Description
BACKGROUND OF INVENTION
Numerous factors must be taken into consideration when collecting
blood for coagulation studies. One of the most important of these,
with which the present invention is concerned, involves the
extrinsic mechanism of blood coagulation. When tissue is damaged as
by puncture of a vein by a needle, a procoagulant, thromboplastin,
is released from the damaged tissue into the blood. To avoid the
presence of tissue thromboplastin in freshly drawn blood samples, a
two-syringe technique is employed.
In the two-syringe technique, the first one or two milliliters of
drawn blood are discarded because in this initial volume, tissue
thromboplastin is present as a result of the vein puncture.
Actually, the first milliliter or two of blood withdrawn washes the
needle free of thromboplastin so that subsequent blood may be
withdrawn through the same needle free of the coagulating substance
and the blood is more truly representative of that of the subject
being studied. However, a number of disadvantages exist in the
conventional two-syringe technique.
Changing syringes while the needle is in the punctured vein is
cumbersome, time consuming, and messy and may result in the needle
being dislodged from the vein or new injury to the tissue may be
caused which may result in further release of tissue
thromboplastin. The present invention provides a syringe which
makes it possible to withdraw two samples of blood from a vein with
a simple pull on an inner plunger member of the syringe. The first
sample of blood is segregated and kept apart from the subsequently
withdrawn analytical sample, and contamination of the analytical
sample with tissue thromboplastin is avoided. The syringe of the
present invention increases the efficiency of blood collection and
improves the consistency of the blood sample. It makes practically
nonexistent chance of contamination of blood samples by tissue
thromboplastin caused by poor technique in blood collection.
SUMMARY OF THE INVENTION
The present invention is a multi-barrel syringe which is so
constructed that it can draw a small amount of blood from a
punctured vein into one compartment of the syringe, and then draw a
larger amount of blood into a separate compartment without
disturbing the position of the needle in the initial puncture or
changing syringes as in the two-syringe technique. These results
are obtained by providing locking means which may fix the outer
barrel of the syringe to an intermediate plunger-barrel allowing an
innermost plunger to be withdrawn to form a first compartment for
receiving the first drawn blood sample between the said plunger and
the intermediate barrel member. At a predetermined position of the
plunger the intermediate barrel member is released from the outer
barrel and fixed to the plunger so that continued withdrawal of the
plunger draws out the intermediate barrel which then acts as a
plunger and forms a second compartment for receiving blood between
the outer barrel and the said intermediate plunger-barrel
member.
THE PRIOR ART
Multi-barrel two-compartment syringes for injecting drugs are known
but insofar as the inventors are aware there has not been described
a multi-barrel two-compartment syringe which automatically permits
blood to be drawn into one compartment and then have subsequent
amounts drawn into a distinct compartment from which it may be
removed for testing without becoming mixed with the first drawn
portion of blood.
THE DRAWINGS
In order that the nature of the invention may be more clearly
understood, reference is made to the accompanying drawings in
which:
FIG. 1 is an elevation partly in cross section of a preferred
embodiment of the syringe of the present invention.
FIGS. 2 and 3 are elevations partly in cross section showing the
syringe in different positions of its operation.
FIG. 4 is an elevation partly in cross section of the lower part of
an alternative structure.
Referring to FIG. 1 it will be seen that the novel syringe of the
present invention comprises an outer barrel 1 provided with a
conventional tip 2 to which a hollow needle (not shown) suited for
intravenous puncture may be attached. The outer barrel is also
provided with a lip 3 or equivalent engaging means.
An intermediate barrel member 4 fits snugly within the outer barrel
member, loose enough to permit easy axial movement but tight enough
to prevent air from leaking into chamber 5, FIG. 3, when the
intermediate barrel is withdrawn. The lower end 6 of the
intermediate plunger-barrel is formed to conform closely with the
shape of the lower inside end 7 of the outer barrel. The structure
should be such that first drawn blood cannot enter between the
outer barrel member and the intermediate barrel member. This may be
assured by forming a tip 22 on the intermediate barrel which fits
into a pocket or recess in the outer barrel. When made of glass the
joining surfaces may be ground. If of resilient plastic, accurately
molded parts will provide a sufficient seal. Rubber O rings may
also be used to provide a good seal.
The intermediate barrel member is provided with lugs 8, 9 or
equivalent means of mounting a locking means 10 as will be
explained hereafter.
An innermost plunger member 11 is provided with a tip 16 which fits
snugly within the intermediate barrel member. Means 12 for grasping
the plunger between the operator's fingers is provided.
The innermost plunger, the intermediate barrel and the outer barrel
members are in telescopic relationship and slide smoothly along
their mutual axis as do the plunger and barrel of a conventional
syringe. Withdrawal of the plunger from the intermediate barrel
forms a chamber 13 into which the first drawn blood can be
introduced through channel 14 in the tip 2.
The innermost plunger is provided with a groove 15 or other means
of engaging stud 18 on the locking means 10.
As noted above, the intermediate plunger-barrel member is provided
with means to mount a locking mechanism. For purposes of clarity in
the drawings only one such locking means is shown. This means may
comprise a rocker arm pivoted 20 to lug 8. A similar rocker arm
will be mounted on lug 9. Studs 18, 19 are provided on each end of
the rocker arm. A spring 21 holds the stud 18 firmly against the
inner-most plunger member as shown in FIG. 1. When the plunger is
in the position shown in FIG. 2, the stud 18 slips into groove 15
as shown in FIG. 2, thus locking the plunger to the intermediate
barrel and releases the outer barrel thus permitting the two
innermost members to act as a single plunger and withdrawal thereof
results in formation of the second chamber 5 as shown in FIG. 3.
The suction created by formation of this second chamber draws blood
into it.
It should be understood that the length of the lower section of the
lever arm, that is the distance from the pivot point 20 to the
locking stud 19 should be such that the lowermost part of the
intermediate barrel fits tightly against the inside bottom of the
outer barrel so that blood may not enter between the two members
while the initial blood is being drawn.
It will also be understood that the location of a locking groove 15
on the inner plunger member will determine capacity of chamber 13
and the volume of blood that may be drawn into it before the
locking mechanism releases the outer barrel and locks the
intermediate barrel to the plunger. The lower the locking groove on
the plunger the greater the volume of the chamber 13 that is
formed. A capacity of 2 milliliters is usually sufficient.
An important variation in the structure of the syringe of the
present invention is shown in FIG. 4. In this modification the tip
22 of the intermediate barrel is extended downwardly a distance
sufficient to form a chamber 23 when the intermediate barrel is
inserted into the outer barrel. This chamber may be filled with a
diluent, an anti-coagulant, a sequestering agent, or some other
solution with which it is desired to mix with the blood sample.
Although it is not a part of the present invention, it is pointed
out that all surfaces which may come in contact with the drawn
blood, particularly when of borosilicate glass, should be coated
with a solution of silicone to avoid activation of the Hageman
Factor of the blood.
The capacity of the second formed compartment of the syringe may
vary by any desired amount from one-half milliliter to 100
milliliters. Usually the volume for blood coagulation studies will
be between 5 and 30 milliliters. These volumes may be determined by
varying the lengths of the outer and intermediate barrels or by
increasing their diameters. Suitable calibration marks may, of
course, be placed on a suitable location on the parts of the
syringe.
Although the manner of using the syringe of the present invention
is believed to be obvious from the foregoing description, the
method of using it will be recapitulated. The operator will, of
course, attach a suitable needle to the tip of the assembled
syringe which will be in the closed position shown in FIG. 1. All
parts should be clean and sterile. The vein from which blood is to
be drawn is punctured and the innermost plunger member 11 is slowly
withdrawn to the position shown in FIG. 2. This draws blood into
chamber 13. When groove 15 comes opposite stud 18 the lever arm 10
will be moved by spring 21 into the position shown in FIG. 2. As
will be seen from the drawing, stud 19 is released from the lip 3
of the outer barrel.
As will be obvious from the drawings, continued withdrawal of the
inner plunger 11 brings with it the intermediate barrel 4 which
then acts as a plunger drawing blood into chamber 5 as the
withdrawal movement is continued. Withdrawal continues until the
desired amount of blood, uncontaminated by tissue thromboplastin,
is collected in chamber 5.
When using the alternative structure shown in FIG. 4 the drawn
blood will be mixed with whatever solution is in chamber 23 at the
start of the operation. Uncontaminated blood is forced out of the
chamber by telescoping the intermediate plunger-barrel to force the
blood out of chamber 5. As noted, the locking means prevents the
inner plunger member from ejecting the blood from sample 13 until
it is released by depressing lever arm 10.
Obviously other means by which the outer barrel may be fixed to the
inner barrel while the plunger is allowed to move axially and then
release the inner barrel from the outer barrel and fix the inner
barrel member to the plunger so that the latter two may move
axially as a unit with respect to the outer barrel will occur to
those skilled in the art of syringe design.
* * * * *