U.S. patent number 3,814,097 [Application Number 05/326,474] was granted by the patent office on 1974-06-04 for dressing.
This patent grant is currently assigned to Imperial Chemical Industries Limited. Invention is credited to David Ganderton, James McAinsh, Gordon Varney.
United States Patent |
3,814,097 |
Ganderton , et al. |
June 4, 1974 |
DRESSING
Abstract
A dressing for administering a drug through the skin of a host
comprising a reservoir for the drug and, located between the
reservoir and the skin of the host when the dressing is in use, a
pad provided with tiny spikes. These tiny spikes augment the
absorption of the drug without causing irritation.
Inventors: |
Ganderton; David (Macclesfield,
EN), McAinsh; James (Macclesfield, EN),
Varney; Gordon (Macclesfield, EN) |
Assignee: |
Imperial Chemical Industries
Limited (London, EN)
|
Family
ID: |
9819069 |
Appl.
No.: |
05/326,474 |
Filed: |
January 24, 1973 |
Foreign Application Priority Data
|
|
|
|
|
Feb 14, 1972 [GB] |
|
|
006692/72 |
|
Current U.S.
Class: |
604/304; 423/563;
600/556 |
Current CPC
Class: |
A61M
37/0015 (20130101); A61F 13/00063 (20130101); A61K
9/0021 (20130101); A61F 13/00068 (20130101); A61F
2013/0017 (20130101); A61M 2037/0007 (20130101); A61M
2037/0023 (20130101) |
Current International
Class: |
A61F
13/00 (20060101); A61K 9/70 (20060101); A61M
37/00 (20060101); A61f 007/02 () |
Field of
Search: |
;128/2W,260,268,253,215,333,214F |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Medbery; Aldrich F.
Attorney, Agent or Firm: Cushman, Darby & Cushman
Claims
What we claim is:
1. A pad for augmenting the absorption of a liquid formulation of a
pharmacologically active material through the skin of a host
comprising a sheet of material, a plurality of tiny hollow fibres
passing through the sheet and projecting from at least one face of
said sheet, said fibres having an external diameter at the end of
the fibre in the range 8 .mu.m. to 100 .mu.m. and projecting from
said sheet from 20 .mu.m. to 1,000 .mu.m and a means on one side of
said sheet material constituting a means for supplying said liquid
material.
2. A pad according to claim 1 wherein the sheet is provided with a
multitude of said tiny hollow fibres.
3. A pad according to claim 1 wherein the fibres are composed of
glass.
4. A pad according to claim 3 wherein the sheet is made from
cellulose acetate.
5. A dressing for administering a liquid formulation of a
pharmacologically active material to a host through the skin of
said host, comprising a pad according to claim 1 said supply means
comprising a reservoir for receiving a liquid formulation of the
pharmacologically active material located to permit said liquid
formulation, when present, to pass from said reservoir and through
said pad to the skin of said host.
6. A dressing according to claim 5 wherein the reservoir comprises
a case with the pad forming one wall.
7. A dressing according to claim 5 which additionally includes
pressure applying means for increasing the pressure in the
reservoir.
8. A dressing according to claim 5 which additionally includes
securing means for attaching the dressing to the skin of the
host.
9. A dressing according to claim 5 wherein the reservoir contains a
plug for the insertion of a means for supplying said liquid
formulation of the pharmacologically active material.
10. A dressing according to claim 9 wherein the pharmacologically
active material is a polypeptide.
Description
This invention relates to a dressing for application to the skin.
In particular, it relates to a dressing the primary use of which is
not to protect, or apply medication to, a wound or lesion, but in
the administration of a pharmacologically active material to man or
an animal.
It is well-known that pharmacologically active materials, including
drugs and medicinal products, may be administered to man or animals
by a variety of routes of which the most important are by mouth, by
injection or topically. However, topical application does not
usually result in the pharmacologically active material becoming
distributed throughout the body of the host, and not all
pharmacologically active materials may be administered by mouth.
Injection is an inconvenient method of administration, especially
if it has to be done frequently, and there is a need for an
alternative.
It is an object of the present invention to provide a dressing
which, on application to the skin, will enable a pharmacologically
active material to pass from a reservoir through the stratum
corneum and be adsorbed sufficiently to become distributed
throughout the body of the host. An essential component of this
dressing is a pad or plaster, provided with minute spikes, which is
located in contact with the skin.
According to the invention therefore there is provided a pad
comprising a sheet of material provided with tiny fibres projecting
from at least one face of the sheet, the fibres being sufficiently
rigid and projecting sufficiently from one face of the sheet such
that upon application of that face of the sheet to the skin of a
host, the fibres penetrate the skin to permit a liquid formulation
of a pharmacologically active material, when present, to pass into
the host and become distributed throughout the body of the
host.
The invention thus provides the basis of a dressing which can be
used as an alternative to injection for the administration of a
pharmacologically active material.
The number of fibres projecting from a unit area of the sheet may
vary widely, but in the preferred embodiments, a multitude of
fibres are used. Thus, for example, while some patches may have as
few as 4 fibres per cm.sup.2, others may have as many as, or more
than, 100 fibres per cm.sup.2 depending upon the diameter of the
fibres; it being necessary that the fibres be spaced apart
sufficiently to penetrate the skin. Usually, the fibres will be
made from material different from that of the sheet, and in such a
case, the fibres are necessarily located within the sheet as well
as projecting from a face of the sheet. However, the fibres may be
made of the same material as the sheet and simply project from the
sheet.
A wide variety of materials, especially plastics materials, are
known which may be used to form the sheet. Particularly useful such
materials are, for example, plasticised or unplasticised
homopolymeric thermoplastics, for example polyvinylchloride,
polyvinylbutyral, polyethylene, polyamides, for example nylon, or
cellulosics such as cellulose acetate; plasticised or unplasticised
copolymeric thermoplastics, for example ethylene vinyl acetate;
cross-linked water soluble polymers, for example polyvinylacetate
or polyvinylpyrrolidone; rubbers, both natural and synthetic, for
example polyisobutylene or polybutadiene; or foams, for example
polyurethane foam, polyester foam or cellulose foam. In this latter
case, the range of materials which may be used is very wide indeed,
but care should be taken to choose a foam which is sufficiently
rigid to support the fibres and yet sufficiently porous. Preferred
plastics materials for the sheet are cellulose acetate or
nylon.
The sheet may also be made of metal, for example stainless steel,
which may either be provided with fibres in the form of fine
stainless steel tubes or projections of metal left round the edges
of holes punched in the metal sheet. Alternatively a former, for
example a naturally spiky material such as a nettle or delphinium
leaf may be coated with a metal to give a pad according to the
invention, or a pad prepared from other materials may be coated
with metal to strengthen the fibres.
The fibres may be made of any material the surface of which is
inert to body tissue and which is sufficiently strong when in the
form of tiny fibres to penetrate the stratum corneum under the
conditions in which the complete dressing is used. Particularly
suitable such materials are, for example, inorganic materials, for
example a glass, carbon, alumina, zirconia or silicon nitride;
organic materials, for example nylon or polyparabenzamide; or
metals, for example stainless steel. Alternatively, a
bio-degradable material may be used. The type of material chosen
for any particular use will depend upon the site at which the
complete dressing is to be applied, the nature of the drug to be
administered and any other features associated with that particular
use of the complete dressing.
In a preferred use of the pad, a reservoir of pharmacologically
active material is arranged to dispense that material on to that
surface of the pad remote from the projecting fibres. In this use,
the pad must be permeable to a liquid formulation of a
pharmacologically active material. This permeability may be
achieved by using fibres in the form of tiny tubes, usually called
capillary tubes, by using a sheet of material provided with a
number of transverse holes, or by using an intrinsically permeable
material for the sheet. If the sheet is made of a foam then the
foam serves to allow passage of the desired liquid formulation. Any
method of combination of methods of rendering the pad permeable may
be used depending upon whether solid or hollow fibres are used and
whether or not an intrinsically permeable sheet is used, but the
use of hollow fibres is considered to be desirable.
The precise diameter of the fibres is not critical provided that
they can penetrate the stratum coneum, but it is preferred that the
diameter be in the range 8 .mu.m. to 100 .mu.m. unless the ends of
the fibres are sharpened in which case, the diameter of the end of
the fibre is preferably in the range 8 .mu.m. to 100 .mu.m. The
length of fibre which projects from the sheet is, however,
important since it must be long enough to penetrate the stratum
corneum, but not be so long that serious irritation is caused. In
this context, a penetration of at least 20 .mu.m. is desirable, and
a penetration of 1,000 .mu.m. is probably the maximum which can be
tolerated, depending upon the site at which the pad is located. The
fibres therefore should project from the sheet for a distance
within the above range, and for preference, within the range 50-500
.mu.m. Clearly, the fibres should be aligned so that they project
from that face of the sheet which is to be applied to the skin of a
host at an angle which will achieve penetration of the skin, such
as an angle of approximately 45.degree.-90.degree. to the face of
the sheet.
It is envisaged that any liquid formulation of a pharmacologically
active material may be used in conjunction with the pad of the
invention provided that the formulation has a sufficiently low
viscosity to pass through the pad by the means provided. Not only
solutions, but suspensions and creams can be used with the
appropriate pad.
A pad according to the invention may be constructed by any suitable
method. Thus for the construction of small pads, the fibres may be
laid individually on a work base and cemented together using a
solution of a plastics material as defined above to form a sheet
containing the fibres. Several such sheets may then be joined to
form a block which on being sliced normal to the fibres, produces a
sheet containing transverse fibres. On washing the surface of such
a sheet with solvent, the fibres can be exposed to any desired
length. Alternatively the fibres may be drawn directly on to a drum
coated with plastics material and while still on the drum coated
with the same plastics material to give a sheet similar to that
produced by hand. Other techniques are the "tack-spin" process for
producing a carpet-like pile of fibres, modified whereby a
micro-mesh grid is used to draw a plastics material in the molten
state into a pad of fibres, or the "flock-spraying" process for
depositing whiskers of organic or inorganic material upon a
plastics backing.
A pad according to the invention can be used to assist the
absorption of a topically applied formulation of a
pharmacologically active material, for example a cream or gel, by
being placed over the applied formulation. In this case, of course,
the pad need not be permeable. However the principal use envisaged
for a pad according to the invention is as part of a dressing for
the administration of a pharmacologically active material to man or
an animal.
According to a further feature of the invention there is provided a
dressing for the administration of a pharmacologically active
material to a host comprising a pad as previously defined in
accordance with the invention in which the pad is permeable to a
liquid formulation of a pharmacologically active material, and a
reservoir for a liquid formulation of a pharmacologically active
material so located that the pharmacologically active material,
when present, can pass from the reservoir and through the pad.
In order that this aspect of the invention may be clearly
understood, two simple embodiments of a dressing according to the
invention will now be described with reference to the accompanying
drawings of which:
Fig. i is a diagrammatic representation of a vertical section of
one embodiment
and
Fig. ii is a diagrammatic representation of a vertical section of
another embodiment.
Referring first to FIG. I, the dressing comprises a relatively
rigid case 1 of metal or hard plastics material in the shape of an
inverted shallow dish provided with a rim 2. Across the case 1,
approximately in line with the rim 2, is a pad according to the
invention in the form of a sheet of plastics material 3, provided
with tiny fibres 4 projecting from the lower face of the sheet 3.
As illustrated, the projection of the fibres 4 from the sheet 3 is
much exaggerated in order to render it visible. Particular pads
which may be used in the dressing are illustrated in the
accompanying Example 1-6, and in the event of such a pad not being
permeable to a formulation of pharmacologically active material by
virtue of the permeability of the sheet or the fibres being hollow,
the pad is made permeable by being pierced in 5-10 places. If
necessary, such intrinsic permeability is augmented by holes
pierced through the pad. The space formed between the pad and the
case 1 forms a reservoir 5, and at the upper part of case 1 (the
base of the inverted dish) is located a means for filling the
reservoir in the form of a hole which is closed by a plug 6, made
of relatively soft material, for example neoprene, which is capable
of re-sealing after a needle has been passed through and then
withdrawn from the plug. Secured to the case 1 are straps 7 which
extend from each side of the case 1.
In use, the dressing is secured upon the skin of the host to whom a
pharmacologically active material is to be administered by means of
the straps 7 so that the fibres 4, projecting from the sheet 3 are
held against the surface of the skin. A liquid formulation of the
pharmacologically active material, usually in the form of a
solution, is filled into the reservoir 5 through the needle of a
hypodermic syringe inserted through the plug 6. When the reservoir
5 is filled, the needle is withdrawn and the plug re-seals. The
dressing is then left in place on the skin of the host until
sufficient pharmacologically active material has been administered
through the skin of the host.
Referring now to FIG. II, the dressing illustrated is similar to
that of FIG. I in that it comprises a relatively rigid case 1, and
a pad, formed from a sheet of plastics material 3 with fibres 4,
forming a reservoir 5 which can be filled with a liquid formulation
of a pharmacologically active material via a plug 6 located in the
side wall of the case 1. The dressing of FIG. II is however
provided with means for applying pressure to the formulation of
pharmacologically active material, when such is present in the
reservoir 5, in the form of a chamber 8 in the upper part of the
case 1, separated from the reservoir 5 by a flexible membrane 9,
and capable of retaining gas under a pressure greater than
atmospheric pressure. In the particular embodiment of FIG. II, the
chamber 8 can contain granules of sodium bicarbonate, preferably
coated with a polymer, so that on admitting an acidic solution to
the chamber 8 via the needle of a hypodermic syringe inserted
through the plug 10, carbon dioxide gas is slowly generated and a
pressure is exerted on the membrane 9.
The embodiment of FIG. II is used in the same way as that of FIG.
I, being secured to the host by straps 7.
Clearly the two embodiments illustrated represent only particular
examples of dressings according to the invention, and many
variations of detail can be envisaged.
Thus the reservoir may be distinct from the pad, for example the
walls of the reservoir may be separate from the case and/or the
pad. The reservoir could be, for example, a sachet of plastics
material permeable to the liquid formulation of the
pharmacologically active material and located within the space
formed by the case and the pad in the embodiments illustrated, or
it could be formed from the case and a permeable wall extending
across the case along the inside of the pad. Alternatively, it
could be in the form of, for example, a foam in which a solution of
the pharmacologically active material can be retained by capillary
action; a capsule which can be filled with pharmacologically active
material to be pierced with a needle when it is desired to admit
that material to the pad; or a piece of wadding which may be
impregnated with the desired pharmacologically active material. As
yet a further alternative, the reservoir may be a gel which may be
impregnated with pharmacologically active material as desired.
When the dressing is provided with pharmacologically active
material and is in use, that material will diffuse from the
reservoir to the pad, and the rate at which this takes place is
dependent upon the nature of the reservoir wall and its thickness,
both of which can be varied as desired. In the cases illustrated
where the pad itself forms one wall of the reservoir, the rate of
diffusion is dependent upon the pad and its fibres.
The dressing may also be provided with a layer of material between
the reservoir and the pad to act as a diffusion layer to control
the rate of delivery of the pharmacologically-active material to
the pad.
As illustrated in FIG. II, the dressing may also be provided with
means whereby pressure is exerted on the formulation of
pharmacologically active material to increase the rate at which it
passes from the reservoir and/or through the pad. Alternatives to
the specific means illustrated are, for example, a distendible
reservoir which can be filled under pressure; a spring-loaded
reservoir which exerts a mechanical or hydrostatic pressure on its
contents; or a pressure bandage which is used both to retain the
dressing in place and to exert pressure on the contents of the
reservoir.
In addition, or as an alternative to, a pressure bandage, the
dressing may be secured to the skin of a host by means of adhesive
tape or an elasticated net, and such securing means may form part
of the dressing itself. As part of the securing means of the
dressing, in order to prevent undue leakage of the formulation of
pharmacologically active material from the periphery of the area of
skin to which the pad is pressed, the area surrounding the pad, for
example the rim 2 in the embodiments illustrated or part of the
straps 7, may bear an adhesive to secure that area to the skin of
the host.
As indicated above, the rate of diffusion of the liquid formulation
of pharmacologically active material from the reservoir to the host
is dependent upon the nature of the reservoir and the nature of the
pad. Clearly, the total amount of material administered to the host
is also dependent upon the surface area of the reservoir and pad.
When an extremely potent drug is to be administered, a small
surface area only is required, and the pad may have an area of only
a few cm.sup.2. For less potent materials, where administration of
a larger amount of material is necessary, a greater surface area is
needed and the dressing may be large enough, say to cover the whole
of a patient's forearm or a major part of the abdomen.
It will be clear that a dressing according to the present
invention, as well as being capable of being used to administer
pharmacologically active materials normally given by injection, can
also be used to administer such materials continuously over an
extended period. Such a method of administration enables the
variation in the concentration of a pharmacologically active
material in the blood of a host, produced by administration of the
material at intervals, to be reduced, and this advantage is not
limited to materials which are normally administered by
injection.
As examples of pharmacologically active materials which are
normally administered by injection and which may be administered by
the use of a dressing according to the invention may be mentioned
polypeptides, for example polypeptide hormones and synthetic
polypeptides possessing some at least of the pharmacological
properties of the hormones, for example insulin, oxytocin,
bradykinin, gastrin, pentagastrin or urogastrone; or
prostaglandins.
As a further feature of the invention there is provided a dressing
as defined together with a liquid formulation of a
pharmacologically active material.
Pads according to the invention are illustrated by the following
Examples, and such pads may be tested for efficacy by comparing the
transfer of a solution containing a pharmacologically active
material through skin in the presence of the pad with the transfer
effected in its absence. Both in vitro and in vivo methods may be
used. The following is an example of such a test:
A pad, prepared as described in Example 2, was applied to a clipped
and shaved area on the back of a rabbit and secured in place by a
rubber pad containing a 2 cm. diameter hole in register with the
prepared area of the pad. One ml. of a solution of C.sup.14 radio
labelled
3-t-butylamino-1-(5-propionamido-naphth-1-yloxy)-2-propanol, a
.beta.-adrenergic blocking agent, in water containing 0.74 mg./ml.
was applied to the pad uniformly over a period of 5 hours. Blood
samples were taken at regular intervals from the ear of the rabbit
and the amount of radioactive drug present measured using a
scintillation counter. The experiment was repeated in the absence
of the pad and again with the stratum corneum of the skin removed
by a hand dermatome. The following results were obtained:
Application to: Peak blood concentration observed Skin less than
2-3 ng./ml. Pad prepared as in Ex. 2 14 ng./ml. Skin minus straum
corneum 48 ng./ml.
These results show that the pad increased the absorption of the
pharmacologically active material through the stratum corneum from
an extent giving a negligible peak blood concentration to nearly
one third of that obtainable when the stratum corneum was
absent.
EXAMPLE 1
Fibres, in the form of glass capillary tubes 40 .mu.m. in external
diameter and approximately 15 cm. long, were laid individually on a
glass plate parallel to each other and about 0.5 mm. apart. The
ends of the tubes were retained on two strips of double-sided
adhesive tape located approximately 13 cm. apart. A solution in
acetone of cellulose acetate containing acetyl triethyl citrate as
plasticiser was brushed on to the aligned glass tubes and the
solvent allowed to evaporate. The process was repeated until a film
0.5-1 mm. thick had been built up. Several such films were prepared
and cut into squares approximately 2.5 cm. .times. 2.5 cm. The
faces of these squares were then brushed with acetone and laid on
top of each other with the tubes all pointing in the same
direction. Pressure was applied to the stack of film for several
hours, causing the individual squares of film to adhere together to
form a cube. This cube was then sliced with a microtome normal to
the axis of alignment of the tubes to produce small sheets of
material about 1-2 mm. thick containing glass capillary tubes
arranged at 1 mm. intervals across the thickness of the sheet. One
face of a small sheet was then etched away by alternately brushing
that surface with acetone and then with water until about 100
.mu.m. of glass capillary tube was exposed projecting from the
surface of the sheet. This condition usually took some 30-40
applications of acetone and water to achieve and the extent of
projection of the tubes was checked by examination of the sheet
under a microscope using oblique illumination. In order to avoid
blockage of the capillary tubes, air was blown through the pad
during the etching process, and this was conveniently achieved by
clamping the pad over the surface of a fine ground glass funnel
through which air was being blown.
The product was a square of cellulose actate sheet having a centre
portion 2 cm. in diameter provided with tiny glass capillary tubes
about 0.5 mm. apart extending through the sheet and projecting from
one surface by about 100 .mu.m.
EXAMPLE 2
The procedure described in Example 1 was repeated except that solid
glass fibres 40 .mu.m. in diameter were used, and the operation of
blowing air through the pad during the etching process was omitted.
The pad was rendered permeable by being pierced with a fine needle
in 6 places in a 2 cm. square.
EXAMPLE 3
A platinum crucible was filled with small spheres of E-glass and
the whole heated to 1,000.degree. C. to melt the glass. The
crucible was then maintained at 1,200.degree. C. for about 2 hours
after which the glass was ready to be drawn into a fibre on a
rotating drum. The drum was first coated with a layer of plastics
material, usually cellulose acetate, by application of a solution
of the plastics material in acetone to the surface of the drum and
evaporation of the acetone. A fibre of glass was then drawn from
the tip of the crucible and wound on to the drum through a guide.
The drum was rotated, and the guide was allowed to traverse the
coated surface of the drum at a speed to give the required density
of wound fibre, usually 1 fibre/mm. The fibre was then cut, and a
coat of plastics material applied to the wound fibre using a
solution in acetone. After the acetone had evaporated, the film of
plastics material with the glass fibres aligned within it was
stripped from the drum. The operation was repeated many times, and
then all the sheets so obtained were then interleaved with sheets
of the same plastics material of the same thickness but not
containing glass fibres. The sheets were treated with a small
amount of acetone and/or methanol as solvent, and by applying
pressure to the sheets, a block was built up in which the glass
fibres were all aligned in the same direction and evenly spaced
apart. The block was then sectioned transverse to the glass fibres
to give small sheets of material about 1-2 mm. thick containing
glass fibres at approximately 90.degree. to the plane of the sheet
and evenly spaced apart. One surface of the sheet was then etched
away using a mixture of acetone and methanol, conveniently 60-70
percent v/v of acetone, to leave the glass fibres projecting from
the surface of the sheet. A particularly convenient technique for
etching a number of such sheets was to secure such sheets to the
circumference of a wheel and, by rotation of the wheel, allow the
sheets to rub against one or more brushes loaded with solvent.
In this technique, the diameter of the drawn fibre could be varied
by variation in the speed of rotation of the drawing drum. Thus
typically, a drawing speed of 0.5 metre/sec. produced a fibre of
about 40 .mu.m. diameter, and a drawing speed of 3 metres/sec.
produced a fibre of 15 .mu.m. diameter.
Also, the extent of projection of the fibre from the surface of the
sheet of plastics material could be varied by controlling the
extent of the etching of the plastics material. In any particular
pad, the fibres did not all project to the same extent, but
nevertheless, a variation in average projection from about 75
.mu.m. to 250 .mu.m., with individual variation from 50 .mu.m. to
400 .mu.m. could be achieved.
In a variation of the above technique, a glass tube of
approximately 1 mm. external diameter was drawn through a heater at
800.degree. C. and wound on to a drum coated with plastics material
as above. By following the above general procedure, sheets of
plastics material provided with tiny, projecting hollow glass
fibres were produced.
By using the techniques described above, a considerable variety of
pads comprising a sheet of plastics material provided with a
multitude of tiny glass fibres projecting from one face thereof
have been prepared. A representative selection of such pads is set
out below:
Plastics Solid or Diameter Projection of Material Hollow glass of
fibre fibre from fibre plastics
__________________________________________________________________________
sheet Cellulose acetate solid 40 .mu.m. ca 150 .mu.m. containing
acetyl 140-340 .mu.m. triethyl citrate 60-180 .mu.m. as plasticiser
60-200 .mu.m. 100-300 .mu.m. 80-240 .mu.m. 120-340 .mu.m. 10 .mu.m.
ca. 150 .mu.m. hollow 40-60 .mu.m. ca. 150 .mu.m. nylon* solid 40
.mu.m. 300-400 .mu.m. * In the case of pads made with nylon as the
plastics material, the sheets without glass fibres were obtained by
compression moulding instead of by evaporation of a solution, and
the pads were etched with methanol.
EXAMPLE 4
The procedure described in Example 1 was repeated using hollow
nylon fibres of 50 .mu.m. external diameter or carbon fibres of 10
.mu.m. diameter to give pads of cellulose acetate provided with
tiny hollow nylon or carbon fibres projecting to about 1.5 .mu.m.
from the surface.
EXAMPLE 5
A sheet of EN 58B stainless steel, 26 .mu.m. in thickness was cut
into discs about 1.5 cm. in diameter and 20 holes punched into each
disc by means of a sewing needle mounted in the chuck of a bench
drill which was lowered, without rotation, on to the steel disc to
a controlled extent. The holes so produced were 78 .mu.m. in
diameter and a burr 104 .mu.m. in length was left projecting from
one side of the steel sheet. The net result was a pad, consisting
of a sheet of steel provided with tiny fibre-like spikes projecting
from one surface, and being permeable to liquid by virtue of the
holes.
EXAMPLE 6
A stainless steel dish 2 cm. in external diameter and 1.5 cm.
internal diameter was provided with 6 holes in the base, each 200
.mu.m. in diameter. Fine steel tubes 200 .mu.m. in external
diameter, 100 .mu.m. in internal diameter were sharpened at one end
and then cemented into the holes leaving 150 .mu.m. of sharpened
tube projecting from the lower face of the base of the dish. The
net result was a pad of stainless steel provided with fibre-like
sharpened hollow steel tubes projecting from one surface.
* * * * *