U.S. patent number 3,810,479 [Application Number 05/298,292] was granted by the patent office on 1974-05-14 for toothbrush having antimicrobial means.
This patent grant is currently assigned to Colgate-Palmolive Company. Invention is credited to Gilbert Dwayne Miles.
United States Patent |
3,810,479 |
Miles |
May 14, 1974 |
TOOTHBRUSH HAVING ANTIMICROBIAL MEANS
Abstract
A toothbrush of normal configuration and structure has a
relatively small well on the side of the brush having the bristles
and in relative proximity thereto. The well contains an
antimicrobial material which is sparingly soluble so that as the
brush is wetted the moisture will dissolve a small portion of the
antimicrobial agent which is then distributed over the bristles by
capillary action thereby sterilizing them.
Inventors: |
Miles; Gilbert Dwayne
(Ossining, NY) |
Assignee: |
Colgate-Palmolive Company (New
York, NY)
|
Family
ID: |
23149871 |
Appl.
No.: |
05/298,292 |
Filed: |
October 17, 1972 |
Current U.S.
Class: |
132/311;
401/268 |
Current CPC
Class: |
A46B
11/00 (20130101); A46B 11/0068 (20130101); A46B
2200/1066 (20130101) |
Current International
Class: |
A46B
11/00 (20060101); A45d 044/18 () |
Field of
Search: |
;132/84,92,93
;401/132,176 ;424/52 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: McNeill; G. E.
Attorney, Agent or Firm: Sylvester, Esq.; Herbert S. Grill,
Esq.; Murray M. Koch, Esq.; Kenneth A.
Claims
What is claimed is:
1. In a toothbrush for repeated use in oral hygiene having a handle
portion of a predetermined color and a bristle containing portion,
the improvement comprising providing a well intermediate the handle
portion and the bristle portion on the same side thereof, the well
containing a slightly water soluble antimicrobial containing
material suitable to sterilize said bristles after use, said
antimicrobial containing material being of a color contrasting with
said predetermined color and being transferred to said bristles by
leaching and capillary action when said toothbrush is wetted after
use.
2. The toothbrush of claim 1 wherein the well has a plurality of
ribs along the side walls thereof.
3. The toothbrush of claim 1 wherein the antimicrobial containing
material is in the form of a pellet having a cross
configuration.
4. The toothbrush of claim 1 wherein the antimicrobial agent is
selected from the group consisting of acriflavine, hexachlorophene
and sulfonamides.
5. The toothbrush of claim 4 wherein the antimicrobial agent is in
a binder selected from the group consisting of polyvinyl alcohol
and polyethylene glycol having an average weight of about 300 to
8,000.
Description
BACKGROUND OF THE INVENTION
It will be appreciated that there is major concern with the
presence of microbes on toothbrushes. Particular attention is
warranted in those situations where a toothbrush is utilized by
more than one person so that there can be a transfer of bacteria
from one person to another. Nevertheless, even when toothbrushes
are allocated for individual use the microbes which are always
present within the human mouth will remain on the bristles and on
the toothbrush proper even though it may be adequately rinsed and
shaken to remove the excess moisture. Small food particles
remaining on the bristles of the brush provide situs for microbial
multiplication so that when it is used again a new more virulent
infestation may occur in the mouth.
It is known that within 4-12 hours after birth, alpha-hemolytic
streptococci (strep viridans) become established as the most
prominent members of the normal resident flora of the mouth and
remain so for life.
Early in life, aerobic and anaerobic staphylococci, gram-negative
diplococci (neisseriae), diphtheroids and occasional lactobacilli
are added. When teeth begin to erupt, the anaerobic spirocheters
and fusiform bacilli and some anaerobic vibrios and lactobacilli
establish themselves. Actinomyces species are normally present in
tonsillar tissue and on the gingivae in adults. Additionally,
yeasts may also occur in the mouth.
It will be appreciated that in view of the extensive flora found in
the mouth positive action should be taken to ensure that flora
which has been conditioned to be harmless in one person's mouth is
not transmitted to another person where some problems could
occur.
The problem attendant toothbrushes not having means for
establishing asepsis has been attacked from a number of positions.
For instance, in one aspect the toothbrush after utilization is
simply dipped into a receptacle containing an antimicrobial agent
such as alcohol. In another embodiment, of fairly recent vintage,
is the technique to expose the bristles of the toothbrush to a
chamber having an ultraviolet producing lamp so that the toothbrush
is continuously stored in an environment having ultraviolet
radiation. In another embodiment the bristles of a brush have been
fabricated of a synthetic material into which has been incorporated
a germicidal material. An example of this can be found in U. S.
Pat. No. 3,294,099. In still another solution a toothbrush has been
constructed having a reservoir in the back of the bristle portions.
The reservoir is filled with an antimicrobial agent and is in
communication with the bristles through suitable apertures between
the bristle holders and the reservoir. This last arrangement would
be under ordinary circumstances quite satisfactory, but for the
expense involved has not become popular.
All of the above described prior art type arrangements have proven
to be satisfactory to a considerable degree. In each case, however,
the primary drawbacks would be in the totalization of the expense
in producing a toothbrush or in the case utilized to house such a
toothbrush.
BRIEF SUMMARY OF THE INVENTION
The present invention sets forth an ingenious arrangement which not
only has the primary duty of solving quite inexpensively the
problem of maintaining a toothbrush in a relative sterilized
condition and at the same time the manner in wyich this is
accomplished also results in an indication as to when a toothbrush
should be replaced. The present concept of the invention is
accomplished by employing a toothbrush which has a relatively
shallow well or receptacle positioned in an area intermediate the
bristle portions of the toothbrush and the handle portion. The well
is also on the side where the bristles are located. The well is
filled with a slug or pellet of an antimicrobial agent of a
sufficient quantity and of a degree of solubility so that the
moisture employed in washing and rinsing the toothbrush gradually
leaches the antimicrobial agent in the pellet so that is is
distributed over the toothbrush in that portion that has become
wet. By making the pellet of a contrasting color to the toothbrush
handle the pellet acts as an indicator when all of the
antimicrobial agent has been solubilized. At that juncture in time,
the owner and user of the toothbrush becomes informed that all of
the antimicrobial agent has been utilized and that is is now a good
opportunity to purchase a new toothbrush.
DETAILED DESCRIPTION OF THE INVENTION
It will be readily apparent that not just any type of antimicrobial
agent may be employed. A number of facets must be considered to
make the antimicrobial agent applicable to carrying out the present
invention. A first consideration, of course, is relative to the
effectiveness as an antimicrobial agent for the bacteria normally
found in the mouth. Secondly, the antimicrobial agent must not be
too soluble in water so that it is dissolved from the well of the
toothbrush in too rapid a manner. On the other hand, it must not be
too insoluble for in such a situation the effectiveness of
obtaining antimicrobial activity is not obtained.
If a binder is used in which the antimicrobial agent is
incorporated, it too should have a degree of solubility so that
additional antimicrobial material may be duly exposed. It is
contemplated within the purview of the invention, however, that the
antimicrobial agent be included as an impregnant in the interstices
of an absorbent pad such as an interconnecting cellular structure
produced from foamed polyurethane. However, such embodiment does
not give the indicator as the cellular pad will remain after all of
the antimicrobial agent has been leached therefrom.
Antimicrobial agents of the phenolic type are applicable as they
are effective at high (1-2 percent aqueous solutions) and low
concentrations, but are generally objectionable in smell and taste.
Hexachlorophene [2,2'- methylenebis (3,4,6 - trichlorophenol)] is
an exception to this. It is not objectionable and is practically
insoluble in water. It was first patented in U.S. Pat. No.
2,250,480.
Another applicable antimicrobial agent is acriflavine which is a
bacteriostatic mixture of 2,8-diamino-10 methylacridinium chloride
and of 2,8-diaminoacridine. It is somewhat soluble in water and is
interesting in that it changes color when in aqueous solution to a
reddish orange (from deep orange).
The choice of antibiotics would be dependent upon the bacteria of
consequence. For instance in the chart below have been set forth
the antibiotic useful for the purpose intended:
Drug of 1st Drug of 2nd Microbe Normally In Mouth Choice Choice 1)
Strep viridans Penicillin Erythromycin 2) Anaerobic streplococans
Tetracycline Penicillin G 3) Vibria comma Tetracycline Streptomycin
Sulfonamide 4) Actisomyces Penicillin G Tetracycline
Cepbalothin
Many antibiotics can be incorporated with binders such as wax, such
as waxy polyethylene glycol, resins, such as polyvinyl alcohol,
fats, solid hydrogenated oils, or infiltrated into a polyurethane
open connecting cellular pad. Most antibiotics are quite water
soluble, however. One gram of procaine penicillin G dissolves in
250 ml. water. Succinylsulfathiazol (U.S. Pat. No. 2,324,013) is an
exception. One gram of this material dissolves in 4800 ml. of
water. Another applicable sulfanilamide is N', N'-dimethyl N.sup.4
-sulfanilylsulfanilamide along with sulfapyridine. Consequently, it
will be appreciated that the applicable bacteriostatic agents would
be hexachlorophene, acriflavin or one of the sulfa drugs.
Preferably the material would be in a suitable soluble binder which
could be of choice.
Suitable binders would be water soluble paraffin waxes such as a
waxy polethylene glycol as exemplified in Pat. No. 3,431,339. Also,
a 5 percent concentration of polyvinyl alcohol would also be
applicable as can be seen from its prior use in a dental stick in
Patent No. 2,623,003.
DRAWINGS OF THE INVENTION
FIG. 1 is a side elevational view of a fragmentary portion of a
toothbrush which is partially in cross section.
FIG. 2 is a top plan view taken along lines 2--2 of FIG. 1.
FIG. 3 is similar to FIG. 2 except that it shows another
embodiment.
FIG. 4 is similar to FIG. 3 but shows still another embodiment.
FIG. 5 is similar to the view of FIG. 2 and is yet to another
embodiment.
EXAMPLES OF THE INVENTION
FIG. 1 depicts in side view the working portion of a toothbrush
wherein 11 refers to the bristles which are secured as tufts in the
base portion 12. The handle 13 is shown as a fragment of the whole.
To the right of the bristles as shown a relatively small well 14 is
shown. This well 14 is designed to carry the pellet 15 comprising
the antimicrobial material or antimicrobial carrying material.
The form of the pellet 15 may take one of a number of forms. For
instance in FIG. 2 the pellet 15 has a cylindrical configuration
with four elongated ribs 16. The ribs function to provide a
friction fit in the well 14 as the pellet need not be adhesively
secured in the well. The well 14 must of course have corresponding
grooves adapted to accept the ribs on the pellet.
In FIG. 3 the pellet has a plurality of corrugations which
correspond to those in the well. FIG. 4 is to a hexagonal shape
while in FIG. 5 the pellet has a cross configuration.
In manufacture the pellets are extruded. The pellets are cut into
suitable lengths for insertion into the handle of the
toothbrush.
EXAMPLE I
By Weight Acriflavine 93.9% Polyvinyl alcohol 5.0% Glycerin 1.0%
Flavoring 0.09% Coloring agent 0.01% (eosin)
The essential ingredient is, of course, the acriflavine, the
polyvinyl alcohol and the glycerin. The above quantities of the
various ingredients are mixed with water to form a paste. The paste
is then molded into a rod like object. In molding the rods the
paste is preferably extrusion molded into the form desired as shown
in the above figures. The rods may be dried by the application of
heat during the molding process or they may be removed from the
molds and dried to drive off the water.
EXAMPLE II
The formulation is similar to Example I, however, hexachlorophene
is substituted for the acriflavine.
EXAMPLE III
Instead of the binder of Example I, polyethylene glycol having an
average molecular weight of 6,000 - 7,500 (carbowax) is
substituted.
Other applicable coloring agents are ponceau red and basic
fuchsia.
While there have been shown and described particular embodiments of
the invention, it will be obvious to those skilled in the art that
various changes and modifications may be made therein without
departing from the invention, and, therefore, it is aimed to cover
all such changes and modifications as fall within the true spirit
and scope of the invention.
* * * * *