U.S. patent number 3,810,456 [Application Number 05/240,529] was granted by the patent office on 1974-05-14 for abortifacient.
This patent grant is currently assigned to Medical Concepts, Inc.. Invention is credited to Harvey Karman.
United States Patent |
3,810,456 |
Karman |
May 14, 1974 |
ABORTIFACIENT
Abstract
An intrauterine device for use as an abortifacient, a method of
making the device, and method of inducing an abortion. The device
is a strip or ribbon of plastic material set in a coiled
configuration. The coiled strip retains a memory of its generally
circular form and tends to maintain a coiled planar configuration
after insertion into the uterus.
Inventors: |
Karman; Harvey (Playa Del Rey,
CA) |
Assignee: |
Medical Concepts, Inc. (El
Segundo, CA)
|
Family
ID: |
22906909 |
Appl.
No.: |
05/240,529 |
Filed: |
April 3, 1972 |
Current U.S.
Class: |
128/830; 128/839;
128/840 |
Current CPC
Class: |
A61B
17/42 (20130101); A61F 6/142 (20130101) |
Current International
Class: |
A61B
17/42 (20060101); A61F 6/00 (20060101); A61F
6/14 (20060101); A61b 019/00 () |
Field of
Search: |
;128/1R,130,127,128,129
;205/53-55 |
References Cited
[Referenced By]
U.S. Patent Documents
Other References
"Permanent Reversible Contraception with an Intra-Uterine Plastic
Spiral", Marguiles, New York, New York, Time, Gynecology, July 31,
1964..
|
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: Cohen; Lee S.
Attorney, Agent or Firm: Harris, Kern, Wallen &
Tinsley
Claims
I claim:
1. An intrauterine device for use as an abortifacient, comprising
in combination:
a retainer having a bottom and a circumferential rim fixed to said
bottom, said rim having a slot therein;
a strip of plastic material of generally rectangular cross section
and set in a multiturn coil with free inner and outer ends, with
said coil positioned in said retainer with the outer turn urged
outwards engaging said rim in coil restraining relation; and
a string affixed to said strip outer end and projecting through
said slot for withdrawing said strip from said retainer through
said slot.
2. An intrauterine device for use as an abortifacient, including in
combination:
a flexible tube having an outer end and an inner end, with said
inner end having a tapered flexible tip;
a retainer having a bottom and a circumferential rim, with a slot
in said rim;
a strip of plastic material set in a multiturn coil within said
retainer, with the outer end of said coiled strip projecting
through said retainer slot into said tube inner end, with said tube
tip overlying said retainer slot; and
a string affixed to said strip outer end and extending through said
tube and out said tube outer end.
3. A device as defined in claim 2 wherein said tube has an arcuate
configuration with an open side of the tapered tip on the concave
side of said tube, and wherein said strip has a tapered flexible
tip at its inner end.
Description
BACKGROUND OF THE INVENTION
This invention relates to abortifacients and in particular to a
device for insertion into the uterus for inducing an abortion, and
to a method for making such a device, and to a method for inducing
an abortion.
Intrauterine devices have been used in the past for preventing
conception. These devices consist of metal or plastic wires and
other shapes of small cross-sectional area and various
configurations, including open and closed loops and helices. The
devices are flexible so that they can be pushed through an
inserter, and they are readily deflected in all directions to
conform to voids in the uterus.
SUMMARY OF THE INVENTION
The intrauterine device is a strip or ribbon of plastic material of
generally rectangular cross section and set in a multiturn coil.
The strip is self-stressed to remain coiled and tends to maintain a
planar configuration, opposing any tendency of the strip to meander
through a void.
The device may be made by winding a strip of plastic material into
a multiturn coil, restraining the strip in the coiled condition,
and then heating the coiled strip for a period of time such that
the strip remains coiled after cooling and retains a memory of the
coiled condition so that it will return to the coiled configuration
after passing through an inserter.
The device is used in inducing an abortion by inserting the device
into the uterus through an inserter, permitting the device to
remain in the uterus for a substantial period of time, such as 6 to
24 hours, and then removing the strip. Often several of the devices
will be used in the treatment, being inserted one at a time, and
removed one at a time. The uterus is evacuated spontaneously
shortly after device removal. With this method, the scheduling of
the procedure may be controlled by the physician.
It appears that the effectiveness of the device is due at least in
part to its presence as a foreign body and to its inherent tendency
to maintain a coiled configuration and its resistance to
deformation from the plane of the coil, i.e., from the plane
perpendicular to the axis of the coil.
It is an object of the invention to provide such a new and improved
intrauterine device and an inserter therefor. Other objects,
advantages, features and results will more fully appear in the
course of the following description. The drawings merely show and
the description merely describes a preferred embodiment of the
present invention which is given by way of illustration or
example.
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a perspective view of an intrauterine device
incorporating the presently preferred embodiment of the
invention;
FIG. 2 is a view similar to that of FIG. 1 showing the device in a
retainer;
FIG. 3 is a view similar to that of FIG. 1 showing the device
partly uncoiled;
FIG. 4 is a side view of the device and retainer of FIG. 2 with an
insertion tube suitable for placing the device;
FIG. 5 is a view of the inserter of FIG. 4, partly in section, with
the device of FIG. 1 ready for use;
FIG. 6 is an enlarged partial sectional view taken along the line
6--6 of FIG. 5;
FIG. 7 is a side view of one end of the device of FIG. 1 showing
the suture and serrations;
FIG. 8 is a view similar to that of FIG. 7 showing an alternate
form for the strip;
FIG. 9 is a view similar to that of FIG. 5 illustrating the use of
a rod for moving the strip through the inserter;
FIG. 10 is an enlarged perspective view of the rod of FIG. 9;
FIG. 11 is an enlarged partial sectional view taken along the line
11--11 of FIG. 9;
FIG. 12 is an enlarged sectional view taken along the line 12--12
of FIG. 9; and
FIG. 13 is an enlarged sectional view of a portion of the inserter
and strip of FIG. 5 showing the tip of the strip.
DESCRIPTION OF THE PREFERRED EMBODIMENT
The intrauterine device is a strip, preferably in ribbon form, of a
flexible plastic material. The strip is relatively large, typically
in the order of 1/32 inch thick, 5/32 inch wide and 14 inches long.
The strip, designated by the reference numeral 20, preferably has a
tapered and rounded tip 21 (see FIGS. 6 and 13), which tip is very
flexible. The strip may be serrated along one side, as seen in
FIGS. 7 and 13. The serrations 22, which may be produced by
embossing or molding, are applied to the side of the strip which
becomes the outer side of the coil. The serrations appear to
enhance the presence and effectiveness of the device in the uterus
and also may be utilized to retain material in liquid or gel or
cream form. A suture or string 24 may be attached to the end 25 of
the strip for removing the strip. Serrations may also be provided
at the inner face of the tip 21, as seen in FIG. 13, for enhancing
the tip flexibility and its tendency to curl.
An alternate configuration for the strip is shown in FIG. 8, with a
series of perforations 27 through the strip. The cavities formed by
the perforations are particularly suited for carrying medications
and other substances into the uterine cavity.
In one process, the strip 20 is initially straight and may be
formed by extrusion or by slitting from sheet stock or by other
conventional processes. The strip is wound into a tight coil,
typically in the order of 1 to 11/4 inch diameter, as seen in FIG.
1. The coiled strip is heated to set it in the coiled
configuration. The coil is restrained during the heating and this
may be accomplished by placing the coil in a cup-shaped retainer 26
which may also be used for subsequent storage and packaging of the
coil. The temperature and duration of the heating operation will
depend upon the size and type of material utilized for the strip
and can readily be determined. Nylon is a preferred material for
the strip. By way of example, a strip of Zytel 101 nylon of the
specific dimensions previously given, may be heated at 212.degree.
F. for 5 to 10 seconds, as by placing it in boiling water, to
provide the desired set.
In an alternate process, the device may be initially formed in the
coiled configuration, as by injection molding.
After cooling, the coiled strip should tend to remain in the coiled
configuration, although some unwinding as seen in FIG. 3 does not
detract from the use of the device. The plastic material of the
coiled strip should retain the generally circular configuration and
should return to the circular form after being pushed through a
length of tubing. Desirably the strip should return to a coil in
the order of 2 inch diameter after passing through a length of
tubing.
The coil with its ribbon or rectangular cross section is a stable
structure which tends to remain coiled and in a planar
configuration. The device resists twist and meandering, and while
the utilimate size and shape it assumes when inserted is a function
of the space available, the inherent tendency to assume the planar
coil form appears to be a significant factor in the effectiveness
of the device.
The strip 20 may be introduced into the uterus through a tube and a
preferred inserter 30 is illustrated in FIG. 4. The inserter is a
tube with an interior cross section corresponding to that of the
strip 20, typically elliptical or rectangular with rounded corners,
and preferably is formed of a flexible plastic material in a
generally arcuate shape. The inserter 30 has a tapered and very
flexible tip 31 with a closed side to the convex side of the
inserter and an open side to the concave side thereof, as best seen
in FIGS. 5 and 6. A flange 32 may be provided at the other end of
the inserter to provide a gripping means.
The device may be packaged for use in the form shown in FIG. 4. The
strip 20 is in the retainer 26 with the end 25 of the strip passing
through a slot 34 in the circumferential wall of the retainer. The
strip end 25 is positioned in the tip end of the inserter 30, with
the string 24 passing through the inserter to the other end.
To use the device the retainer 26 is removed and the strip is
pulled into the inserter to a position with the strip tip 21 at or
within the inserter tip and with the strip end projecting from the
inserter.
Next the inserter is guided through the cervical canal into the
uterus and may be manipulated as a sound to locate a void. The
arcuate shape of the inserter facilitates the sounding action. The
feather tapered, flexible tip 31 readily bends as seen in FIG. 9,
substantially reducing the likelihood of perforation of the wall of
the uterus. After a void is located, the strip may be advanced
through the inserter by manually grasping the end 25. If no
obstruction is encountered, the strip may be pushed through the
inserter, as by a push rod 40, with the strip emerging from the
inner end at the tip 31, as seen in FIG. 9. The inserter preferably
is shorter than the strip so that the initial exiting of the tip
end 21 can be manually controlled by grasping the other end of the
strip.
In the preferred configuration of the tip 31 as illustrated in the
drawings, the extreme end is flat and quite flexible so that it
will readily bend on encountering the wall of the uterus to avoid
damage to the wall, and also to serve as a guide for the tip of the
strip 20, as seen in FIG. 9. The tip 21 of the strip also is quite
flexible so as to avoid damage. With the inherent coil
configuration, the emerging strip tends to assume the coiled form,
further reducing the likelihood of damage. The tip 21, while being
flexible, retains its curvature and avoids any spearing action
during insertion.
The push rod 40 typically is a length of plastic with enlarged ends
41 to act as a piston for pushing the strip 20 through the inserter
30 into the uterus. After the strip has been pushed out of the
inserter, the rod and inserter may be removed.
As the strip emerges from the inserter it tends to return to its
initial multiturn coil configuration such as is shown in FIGS. 1
and 3. In the moist, warm environment, the strip may assume a
larger diameter such as 3 to 4 inches, or even larger, but there is
very little force in this expansion. In a typical treatment several
of the devices may be inserted, one after another, depending upon
the interuterine space available.
The device or devices are left in place in the uterus for a
substantial period of time, typically 6 to 24 hours and may be
removed at a scheduled time in the conventional manner by means of
the string 24. It has been found that contractions generally do not
occur while the device is in place but may commence shortly after
removal. This delay and its predictability is of great aid in
scheduling the final stage of the procedure.
Although an exemplary embodiment of the invention has been
disclosed and discussed, it will be understood that other
applications of the invention are possible and that the embodiment
disclosed may be subjected to various changes, modifications and
substitutions without necessarily departing from the spirit of the
invention.
* * * * *