U.S. patent number 3,807,386 [Application Number 05/245,945] was granted by the patent office on 1974-04-30 for radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation.
This patent grant is currently assigned to Commissariat A L'Energie Atomique. Invention is credited to Gilles Delouche, Jean-Antoine Rocoplan.
United States Patent |
3,807,386 |
Rocoplan , et al. |
April 30, 1974 |
RADIOACTIVE SOURCE APPLICATOR FOR UTERO-VAGINAL PLESIOCURIETHERAPY
ACCORDING TO THE METHOD OF NON-RADIOACTIVE PREPARATION
Abstract
The applicator comprises a uterine probe and two vaginal probes,
a coupling member consisting of a polyhedral block having low
density and transparent to X-rays, the block being provided with a
central passageway for the insertion of the uterine probe and two
symmetrical oblique passageways for the insertion of the two
vaginal probes, two cylindrical plugs resting on the coupling
member and each having a passageway for inserting the extremity of
one vaginal probe. The coupling member is provided with cylindrical
cups corresponding in the shape to the plugs and each located at
one end of a vaginal-probe passageway. The generator-lines of the
cups are inclined to the axes of the passageways of the plugs at an
angle which is slightly different from 90.degree..
Inventors: |
Rocoplan; Jean-Antoine
(Boulogne, FR), Delouche; Gilles (Paris,
FR) |
Assignee: |
Commissariat A L'Energie
Atomique (Paris, FR)
|
Family
ID: |
37398919 |
Appl.
No.: |
05/245,945 |
Filed: |
April 20, 1972 |
Current U.S.
Class: |
600/6 |
Current CPC
Class: |
A61M
31/00 (20130101); A61N 5/1016 (20130101) |
Current International
Class: |
A61N
5/10 (20060101); A61n 005/00 () |
Field of
Search: |
;128/1.1,2.2,2A,303,303.1,323,345 ;250/16S |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Howell; Kyle L.
Attorney, Agent or Firm: Craig & Antonelli
Claims
What we claim is:
1. A radioactive source applicator for utero-vaginal
plesiocurietherapy according to the method of non-radioactive
preparation, wherein said applicator comprises a tubular uterine
probe and two tubular vaginal probes, a coupling member constituted
by a polyhedral block formed of a low density material transparent
to X-rays, said block being provided with a central passageway for
receiving the uterine probe and with two oblique passageways which
are symmetrical with respect to said central passageway for
receiving the two vaginal probes, and two cylindrical plugs each
traversed by a passageway through which the vaginal probes extend,
said plugs being in contact with said coupling member, said
coupling member being provided with hollowed-out portions in the
form of cylindrical cups corresponding in shape to said plugs and
each located at one extremity of a vaginal-probe passageway, said
plugs adapted to rest in said hollowed-out portions, the direction
of the longitudinal axes of said cylindrical cups being inclined to
the direction of the longitudinal axes of the passageways of said
cylindrical plugs at an angle which is slightly different from
90.degree..
2. A radioactive-source applicator according to claim 1, wherein
the uterine probe and the two vaginal probes are constructed of a
plastic material which is sterilizable under radiation.
3. An applicator according to claim 1, wherein each vaginal probe
is sealed by means of an added end-cap.
4. An applicator according to claim 1, wherein each plug includes
two removable end-caps permitting the introduction of discs of
heavy metal.
5. An applicator according to claim 2, wherein each plug includes
two removable end-caps permitting the introduction of discs of
heavy metal.
6. An applicator according to claim 3, wherein each plug includes
two removable end-caps permitting the introduction of discs of
heavy metal.
Description
This invention relates to a radioactive source applicator for
utero-vaginal plesiocurietherapy according to the method of
non-radioactive preparation.
It is known that the majority of methods of treatment by
plesiocurietherapy require the introduction of a probe in the
uterus and of a colpostat in the vagina.
In the oldest methods of treatment by plesiocurietherapy, these two
instruments (probe and colpostat), known as applicators, were
loaded with radioactive sources before being brought into the
operating room and placed in position in the patient, which gave
rise to major disadvantages.
The considerable improvements made in the field of
plesiocurietherapy over the past few years have led to the
application of the so-called non-radioactive preparation technique
which consists in dissociating the positioning of applicators
(probe and colpostat) from the positioning of radioactive sources
in these applicators.
In accordance with this technique of non-radioactive preparation,
the following operations are performed:
1. THE APPLICATOR WHICH IS FITTED AT THE END OF A SO-CALLED OUTER
TUBE IS INSERTED INTO THE VAGINA;
2. THE OUTER TUBE IS ATTACHED TO A FLEXIBLE SHEATH WHICH IS JOINED
TO AN APPARATUS KNOWN AS A SOURCE PROJECTOR, FOR EXAMPLE OF THE
TYPE DESCIRBED IN U.S. Pat. application Ser. No. 11,226, filed Feb.
13, 1970, now abandoned, and pseudo-sources, that is to say
non-radioactive sources, are transferred by means of this projector
into said outer tube, then into the applicator and the vagina;
3. THE OUTER TUBE IS FREED FROM THE SHEATH;
4. POSITIONING OF THE APPLICATOR IS CHECKED BY RADIOGRAPHY OR BY
RADIOSCOPY;
5. THE PROJECTOR UNIT IS LOADED WITH RADIOACTIVE SOURCES, THE OUTER
TUBE IS AGAIN ATTACHED TO THE SHEATH, WHEREUPON SAID RADIOACTIVE
SOURCES ARE TRANSFERRED INTO THE OUTER TUBE, THEN INTO THE
APPLICATOR AND THE VAGINA.
In point of fact, the majority of applicators at present in use are
metallic and have the disadvantage of being heavy, which makes it
difficult to maintain them in the irradiation position throughout
the period of treatment; moreover, their poor X-ray transparency
does not make it possible to obtain a good control negative.
Different designs have been developed in order to overcome these
disadvantages (applicators constructed in particular of light
material such as plastic, rubber, neoprene, polyethylene) but these
also are subject to the following disadvantages:
A. - The material of which the applicator is formed does not
readily withstand sterilization, especially sterilization by
radiation. This makes the applicator unsuited for pre-sterilization
prior to use and for spray-jet treatment after use. As a further
consequence, the applicator has to be carefully cleaned and
sterilized each time before use.
Moreover, the constituent material of applicators is often
delicate, is subject to ageing and therefore to a further major
drawback in regard to storage stability; in addition, the
projector-unit tubes which serve to place the radioactive sources
in the irradiation position are often so designed as to permit
introduction only in a rectilineal position by reason of the fact
that, if the outer tube containing the applicator is bent, its
section becomes ovalized and thus prevents easy introduction or
withdrawal of radioactive sources.
b. - That portion of the applicator which is intended to receive
the vaginal sources (namely the portion known as a colpostat) is
not provided with any shield for reducing the dose applied to sound
radiation-sensitive tissues such as the vesical or rectal
walls.
c. - In the irradiation position, the assembly consisting of
uterine probe and colpostat is coupled by means of a metallic
spring or else may not be coupled, which gives rise to two
disadvantages.
The first disadvantage is to make it very difficult to introduce
the applicator through the opening of the speculum; the second
disadvantage arises from the fact that the assembly of vaginal and
uterine sources cannot be maintained in a fixed position. As a
result, even accurate positioning of the applicator does not give
any guarantee of satisfactory position-maintenance throughout the
period of treatment.
d. - The number of possible respective positions of the vaginal
sources with respect to the uterine source is either too small
(three, for example, with three sizes of vaginal plugs) or else may
be infinite if no component is provided for adjusting and
maintaining a fixed respective position. As a result, the dosimetry
is either very difficult to calculate or else does not have any
parameters of variation to permit adaptation both to the patient's
anatomy and to the stage of development of the cancerous
lesion.
The present invention relates to an applicator which is free from
the disadvantages noted in the foregoing.
The precise object of the invention is to provide a radioactive
source applicator for utero-vaginal plesiocurietherapy according to
the method of non-radioactive preparation, said applicator being
characterized in that it comprises a uterine probe and two
colpostats or vaginal probes, a coupling member constituted by a
polyhedral block formed of material which has low density and is
transparent to X-rays, said block being provided with a central
passageway which serves to insert the uterine probe and with two
oblique passageways which are symmetrical with respect to said
central passageway and serve to insert the two vaginal probes, and
two cylindrical plugs each traversed by a passageway which serves
to insert the extremity of a vaginal probe and rests on said
coupling member, said member being provided with hollowed-out
portions in the form of cylindrical cups corresponding in shape to
said plugs and each located at one extremity of a vaginal-probe
passageway, the direction of the generator-lines of said
cylindrical cups being inclined to the direction of the axes of the
passageways of said cylindrical plugs at an angle which is slightly
different from 90.degree..
Further properties and advantages of the present invention will be
brought out by the following description in which one embodiment of
the applicator according to the invention is given by way of
explanation and not in any limiting sense, reference being made to
the accompanying drawings, in which:
FIG. 1 is a sectional view showing the applicator in accordance
with the invention and as positioned in the patient;
FIG. 2 is a perspective view showing the same applicator alone.
The applicator according to the invention is essentially composed
of a uterine probe 1 and of two vagina probes (or colpostats) 2 and
3 which are maintained in rigidly fixed relation during the
application by means of a coupling member 4 and are disposed at the
end of so-called outer tubes 10. The uterine probe 1 and the
vaginal probes 2 and 3 are constituted by a plastic tube (for
example of polyethylene) which is sterilizable under radiation. The
internal diameter of the probes is chosen so as to permit ready
introduction of flexible source-holders even with substantial
curvatures or precurvatures of the probes. The external diameter of
the probes 1 to 3 is chosen so as to leave a thickness of plastic
material which is sufficient to endow the probes with compressive
strength but is not too great in order to maintain flexibility of
the material (thickness comprised between 15 and 20 percent of the
external diameter).
Each vaginal probe is sealed by an added end-cap 5 which is bonded
in the hot state, thus making the interior of the probe impervious
to infiltrations and secretions and also sufficiently strong to
prevent any source-holder from piercing the extremity and causing
injury to the patient.
Each vaginal probe 2 or 3 supplies a plug 6, the axis of which
makes an angle of approximately 100.degree. with the axis of the
corresponding vaginal probe in order to ensure better holding in
place or retention within the vaginal fornices. Each plug 6
comprises two removable end-caps 7 so as to permit the insertion of
discs of heavy metal (such as depleted uranium, lead, tungsten and
the like) which serve to shield the highly radiation-sensitive
vesical or rectal walls.
The applicator can be constructed in a number of different sizes
which differ in the dimensions of the plugs 6 and of the coupling
member 4.
The coupling member 4 slides along the probes and can be introduced
after positioning of the uterine probe 1 and the vaginal plugs 6.
Member 4 is provided with two sets of recesses or hollowed-out
portions 8 having the shape of cylindrical cups which are intended
to accommodate the vaginal plugs 6. The arrangement of said
recesses 8 makes it possible to obtain in the case of each size of
plug two respective arrangements of the vaginal probes 2 and 3,
namely a convergent arrangement in one case (as shown in FIG. 2)
and a divergent arrangement in the other case (as shown in FIG. 1).
There can thus be obtained six fixed distances between the vaginal
sources and this makes it possible on the one hand to adapt the
applicator to the patient's anatomy and, on the other hand, to
utilize an atlas of precalculated isodose curves (corresponding to
the respective fixed positions of the radioactive sources within
the interior of the probes).
The constituent material chosen for the coupling member is intended
to have low density and to be transparent to X-rays (expanded
polystyrene, for example).
A collar 9 serves to support the applicator assembly in a more
effective manner.
The applicator in accordance with the invention, as constructed of
plastic material, has the following advantages over applicators of
the prior art:
a. - The constituent material of the applicator is light in weight
for tolerance by the patient and retention during the period of
treatment; the applicator can be sterilized in a plastic bag by
radiation and permits introduction by means of curved tubes.
b. - The dimensions of the carrier tubes are such as to permit the
introduction of radioactive sources in the case of all degrees of
curvature of said tubes; moreover, the diameter of the uterine
probe 1 is chosen so as to prevent excessive proximity of the
tissues in the irradiation position (this being the case with
diameters which are too small) and excessive prior expansion of the
uterine duct under anaesthesia (5 to 6 mm).
c. - Each of the two vaginal plugs 6 of the colpostats is hollow in
such manner as to permit X-ray detection and is additionally
provided with two end-caps 7 for the introduction of discs of heavy
metal (tungsten, lead, for example) which serve to shield the
radiation-sensitive front and rear walls of the patient.
d. - The coupling member 4 of lightweight material which is
transparent to X-rays makes it possible during the application to
maintain the uterine probe 1 and the vaginal probes 2 and 3 in a
strictly geometrical position.
* * * * *