U.S. patent number 3,804,094 [Application Number 05/330,461] was granted by the patent office on 1974-04-16 for body fluid absorbent material containing periodic acid as deodorizing agent.
This patent grant is currently assigned to L'Oreal. Invention is credited to Koovi Gatien Dossou, Martine Gascon, Georges Manoussos.
United States Patent |
3,804,094 |
Manoussos , et al. |
April 16, 1974 |
BODY FLUID ABSORBENT MATERIAL CONTAINING PERIODIC ACID AS
DEODORIZING AGENT
Abstract
An absorbent material for use in absorbing body fluids, has a
fluid permeable outer portion impregnated with deodorizing amounts
of periodic acid.
Inventors: |
Manoussos; Georges (Paris,
FR), Dossou; Koovi Gatien (Vert-Galant par Vaujours,
FR), Gascon; Martine (Aulnay-sous-Bois,
FR) |
Assignee: |
L'Oreal (Paris,
FR)
|
Family
ID: |
19726942 |
Appl.
No.: |
05/330,461 |
Filed: |
February 7, 1973 |
Foreign Application Priority Data
Current U.S.
Class: |
604/359; 424/401;
424/668; 604/368; 604/378; 424/430; 604/360; 604/375; 604/400 |
Current CPC
Class: |
A61L
15/18 (20130101) |
Current International
Class: |
A61L
15/16 (20060101); A61L 15/18 (20060101); A61f
013/16 () |
Field of
Search: |
;128/285,29R,296
;424/150,27-28 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Rosenbaum; Charles F.
Attorney, Agent or Firm: Cushman, Darby & Cushman
Claims
What is claimed is:
1. An absorbent material for absorbing body fluids having in a
fluid permeable outer portion thereof which is in direct contact
with the body periodic acid in amounts effective to deodorize said
body fluids.
2. The absorbent material of claim 1 comprising a shaped article
made of woven or non-woven cellulose, wool or synthetic textile
fibers.
3. The absorbent material of claim 2 wherein said absorbent
material comprises an absorbent core essentially surrounded by said
fluid permeable outer portion which is in direct contact with the
body, said outer portion being saturated with 3-10 mg of said
periodic acid.
4. The absorbent material of claim 3 wherein said outer portion is
saturated with 4-7 mg of said periodic acid.
5. A sanitary napkin for absorbing fluid associated with menstrual
discharge comprising a body of an absorbent material having a fluid
permeable outer portion for contact with vaginal mucous, said outer
portion containing periodic acid in amounts effective to deodorize
said fluid associated with menstrual discharge.
6. The sanitary napkin of claim 5 wherein said absorbent material
comprises an absorbent core essentially surrounded by said fluid
permeable outer portion which is in direct contact with the vaginal
mucous, said outer portion being saturated with 3-10 mg of said
periodic acid.
7. The sanitary napkin of claim 6 wherein said outer portion is
saturated with 4-7 mg of said periodic acid.
8. The sanitary napkin of claim 5 wherein said absorbent material
is woven or non-woven cellulose, wool or synthetic textile fibers
or mixtures thereof.
Description
This invention relates to an absorbent material for absorbing body
fluids and in a particular embodiment thereof to a catamenial
device or sanitary napkin for absorbing fluid associated with
menstrual discharge.
Heretofore, it has been known to utilize in an absorbent material
for absorbing body fluids, and especially in sanitary napkins, as a
deodorizing agent, a bactericide or a fungicide, inasmuch as these
agents are known to act directly on the micro-organisms of the
vaginal flora by killing such micro-organisms. It is also known
that the formation of odors associated with menstrual discharge are
occasioned by the biological degradation of the menstrual discharge
by these micro-organisms to form ammonia, dimethylamine and
particularly trimethylamine as well as other basic substances. Thus
while the use of bactericides and fungicides has been found
effective to eliminate the source of such odors, by destroying the
micro-organisms, however, it has also been found that the use of
these bactericides and fungicides is also disadvantageous in that
they tend also to destroy the vaginal flora. This harmful effect
thus significantly minimizes a widespread acceptance of sanitary
napkins containing bactericides and fungicides and gynecologists
generally recommend they not be used.
It has also been proposed to utilize certain oxidizing agents, such
as peroxides, as a deodorizing agent in sanitary napkins. These
known oxidizing agents however have been found to be generally
inefficient in their deodorizing activity. They have also been
found to provoke irritation of the vagina and even to destroy at
least part of the vaginal flora.
The applicants have now surprisingly found that it is possible to
eliminate the formation of odors associated with menstrual
discharge without disadvantageously affecting the vaginal flora by
providing a sanitary napkin comprising a body of an absorbent
material having a fluid permeable outer portion for contact with
the vaginal mucous, said outer portion containing periodic acid in
amounts effective to deodorize said fluid associated with menstrual
discharge.
In accordance with this embodiment of the invention, when the
sanitary napkin is applied directly on the pelvic region,
particularly on the vulva and perineum, essentially no irritation
is experienced by the user and the periodic acid present in the
napkin does not destroy the micro-organisms of the vaginal flora,
thereby maintaining a physiological balance. It has also been
observed that the elimination of undesirable odors is rapid and
that the deodorizing effect persists for even several hours after
removal of the sanitary napkin.
Thus, the sanitary napkins of the present invention exhibit several
significant advantages over presently known catamenial devices such
as non-irritation of the vulva and perineum regions, preservation
of the vaginal flora, rapid and essentially total elimination of
undesirable odors associated with menstrual discharge and a
prolonged deodorizing activity, even after removal of the sanitary
napkin.
Tests have been conducted to show, unequivocally, that the
micro-organisms present in the vagina are not destroyed in the
presence of the periodic acid present in the sanitary napkin of
this invention. Such micro-organisms include the following:
Bacillus Subtilis, Sarcina Lutea, Escherichia Coli, Proteus
Vulgaris, Staphylococcu Epidermitis, Streptococcus Fecalis,
Herellea Vaginicola, Saccaromyces Cerevisiae, Lactobacillus
Acidophilus, Lactobacillus Bifudis and Micrococcus Aureus. It can
thus be concluded that the periodic acid, in not destroying these
micro-organisms, directly acts rather on the products of biological
degradation of the menstrual discharge, as described above, and
thus avoids destroying the vaginal flora.
For instance, it has been observed that when there is applied to an
absorbent material saturated with periodic acid a culture of
micro-organisms as described above, the culture of micro-organisms
does not develop in those areas which have been subjected to the
action of periodic acid. However, when the absorbent material
containing the periodic acid is removed, it is observed, after a
period of about 24-48 hours, that the culture develops under normal
conditions and that the micro-organisms which have been subjected
to the action of the periodic acid can be used to grow other
cultures which develop in the same manner as if they had been grown
from micro-organisms not subjected to the action of periodic
acid.
Thus, it has been observed that activity characteristics of
periodic acid provide acceptable levels of the elimination of
undesirable odors over a prolonged period, even when the sanitary
napkin containing the same has been removed. For example, it has
been noted that the elimination of these odors continued to be
effective five hours after removing the sanitary napkin of this
invention, even when this sanitary napkin was replaced by a
conventional cantamenial device not containing the active
deodorizing agent of this invention.
Furthermore, the safety of periodic acid has been verified by the
following tests involving a vaginal injection of the same on three
animal species: a rabbit, a guinea pig and a rat. An aqueous
solution of the following concentration (2-5 ml of a N/2 solution
for the rabbit; 3-5 ml of a N/2 solution for the guinea pig; and
5-8 ml of a N/2 solution for the rat) is administered by a syringe
in the vagina of these animals each day for a period of 15 days.
The animals were then killed and the autopsy performed on each
revealed that the vagina was in perfect shape. Furthermore,
biopsies of the vagina were carried out and in all cases normal
histological images were obtained.
The absorbent material used to produce the device of the present
invention can be woven or non-woven cellulosic material (such as
cotton), wool or synthetic textile fibers, such as those of
viscose, rayon and the like. Obviously other conventionally
employed absorbent materials used to produce sanitary napkins,
dressings or bandages can also be employed. In one embodiment of
this invention, a sanitary napkin can be made up of several
superimposed layers of a selected absorbent material, shaped to the
desired configuration, such as an elongated body, to form the core
which then can be essentially surrounded by a fluid permeable outer
portion, for instance a layer of gauze or netting conforming to the
selected configuration. Obviously other shapes and assemblies of
absorbent materials can be employed depending upon the desired end
use, such as for a medical bandage or dressing. The entire
absorbent material need not be impregnated or saturated with
periodic acid, it having been found that only the fluid permeable
outer portion of the absorbent material which is in direct contact
with the body need contain the deodorizing agent of the present
invention. Thus, in a sanitary napkin, it is only necessary that
the outer layer or portion of the napkin which comes into contact
with the pelvic region need contain the periodic acid.
The quantity of periodic acid present in the fluid permeable outer
portion of the absorbent material can be quite small thereby
avoiding any possible harmful effect when the absorbent material is
in direct contact with the body. Generally the periodic acid is
present in amounts of about 0.015 to 0.5 mg/cm.sup.2 grams per
square inch, preferably about 0.02 to 0.35 mg/cm.sup.2 grams per
square inch in the fluid permeable outer portion of the absorbent
material which comes into direct contact with the body. For
conventional size sanitary napkins having a surface area of about
100 to 200 cm.sup.2 this amounts generally to about 1.5 - 100 mg
while for conventional tampons having a surface area of about 20-30
cm.sup.2 this amounts to about 0.3 - 15 mg (total) of periodic acid
in the outer portion of the napkin.
The present invention also relates to a method for preparing an
absorbent material for absorbing body fluids, said material
comprising an absorbent core essentially surrounded by a fluid
permeable outer portion, said method comprising impregnating a
portion of an absorbent material with a solution of periodic acid
in a solvent selected from the group consisting of water and an
aqueous alcoholic solution, evaporating said solvent from said
portion and assembling said portion about said core to form said
absorbent material. Generally, the solvent is evaporated by
subjecting the portion of absorbent material which constitutes the
fluid permeable outer portion of the absorbent material to a
temperature in the range of about 30.degree.-80.degree. C. The
absorbent material of the present invention can also include
conventionally employed adjuvants such as perfume, antiseptics,
antibiotics, blood coagulants, disinfectants, local anesthetics,
coloring agents and the like, the choice of any particular adjuvant
depending upon the ultimate use of the absorbent material as a
dressing, medical bandage, diaper, sanitary napkin or the like.
The following examples describe the production of a sanitary napkin
according to the teachings of the present invention and are to be
considered as exemplary only.
Example 1
Material to be used as the fluid permeable outer portion of a
sanitary napkin and known under the trademark CRYLOR (polyamide
synthetic fiber) was impregnated with a N/10 aqueous solution of
periodic acid. The material was then placed in an oven at a
temperature of about 37.degree. C for a time sufficient to
evaporate essentially all the water therefrom. The dried material
was then assembled about a core of absorbent material to constitute
the said fluid permeable outer portion of the resulting sanitary
napkin which had a total weight of 15 g and which contained 8 mg of
periodic acid.
This sanitary napkin used in a conventional manner eliminates the
formation of undesirable odors and does not destroy the vaginal
flora. Further the deodorizing activity of the periodic acid
persisted for a period of about 5 hours after removal of the
napkin.
The quantity of periodic acid (8 mg) impregnated on the sanitary
napkin was determined using another outer portion impregnated with
essentially the same solution and dried under essentially the same
conditions. This sample was then impregnated with water and the
resulting aqueous solution was potentiometrically dosed using a
N/50 solution of trimethylamine.
Example 2
Non-woven cotton material to be used as the fluid permeable outer
portion of a sanitary napkin is impregnated with a N/5 aqueous
solution of periodic acid. The material is then dried in an oven at
a temperature of about 45.degree. C to evaporate the water, after
which it is assembled about a core of absorbent non-woven cotton to
constitute the said fluid permeable outer portion of the resulting
sanitary napkin which had a total weight of 13 g and a periodic
content of 4 mg. The periodic content was determined essentially in
the same way as set forth in Example 1, using a sample napkin
prepared in essentially the same way.
Example 2 is repeated except that in one instance the absorbent
material employed was rayon and the quantity of periodic acid of
the resulting napkin was 3.5 mg and in another instance the
absorbent material was viscose and the quantity of periodic acid of
the resulting napkin was 7 mg.
Each of these sanitary napkin, conventionally employed, rapidly
eliminated undesirable odors and exhibited prolonged activity
without destroying the micro-organisms of the vaginal flora.
Further, after removing each of the napkins, the deodorant activity
persisted for about 5-8 hours.
Example 3
Cotton fabric to be used as the fluid permeable outer portion of a
cylindrically shaped sanitary napkin is saturated with a N/10
aqueous solution of periodic acid. The thus impregnated cotton
fabric is dried at a temperature of about 30.degree.-40.degree.C
after which it is assembled about a core of absorbent cotton fabric
to constitute essentially the outer portion of the resulting
sanitary napkin. The resulting assembly is then enclosed in an
outer cotton netting or gauze to provide a sanitary napkin weighing
about 5 grams and containing about 5 mg of periodic acid, this
quantity being determined in essentially the same manner as
described in Example 1.
The resulting sanitary napkin, used in a conventional manner,
essentially eliminated the formation of undesirable odors and did
not destroy the bacterial flora of the vagina. Further, the
deodorizing activity of the periodic acid persisted for a period of
about 5-6 hours after removal of the sanitary napkin from the
vagina.
* * * * *