U.S. patent number 3,802,097 [Application Number 05/297,885] was granted by the patent office on 1974-04-09 for dna model kit.
This patent grant is currently assigned to Or-Da Industries Limited. Invention is credited to Alfred I. Gluck.
United States Patent |
3,802,097 |
Gluck |
April 9, 1974 |
DNA MODEL KIT
Abstract
A kit for constructing a DNA (deoxyribonucleic acid) molecule,
and for demonstrating replication during mitosis, comprises, a
plurality of groups of chips, each group designating a component of
the DNA molecule, interlocking connectors carried by the chips
enabling them to be snap-fitted into others according to certain
predetermined combinations, a common base supporting the lower end
of the DNA molecule and carrying a supporting bar supporting the
upper end of the DNA molecule, the supporting bar being rotatable
180.degree. or 360.degree. and lockable in the rotated condition.
The common base carries four equally-spaced supporting elements,
such that a double-strand molecule may first be constructed by
supporting the lower ends of the strands on the two middle
elements, and then replication by mitosis may be demonstrated by
splitting the molecule into two strands, pivoting the two strands
supported on the middle elements, so that each faces one of the
remaining two elements, and then constructing two double-strand
molecules from the two strands.
Inventors: |
Gluck; Alfred I. (St. Nof Yam,
IL) |
Assignee: |
Or-Da Industries Limited
(Kiryat Weizmann Rehovat, IL)
|
Family
ID: |
23148129 |
Appl.
No.: |
05/297,885 |
Filed: |
October 16, 1972 |
Current U.S.
Class: |
434/279 |
Current CPC
Class: |
G09B
23/26 (20130101) |
Current International
Class: |
G09B
23/26 (20060101); G09B 23/00 (20060101); G09b
023/26 () |
Field of
Search: |
;35/18A,19R,20
;46/25 |
References Cited
[Referenced By]
U.S. Patent Documents
Other References
Science Teaching Aids Co., Catalogue entitled "STA Models for
Science", received Oct. 1964, pp. 16, 17..
|
Primary Examiner: Skogquist; Harland S.
Attorney, Agent or Firm: Barish; Benjamin J.
Claims
What is claimed is:
1. A kit for constructing a double-strand chemical molecule having
a twist therein, and for demonstrating its replication by mitosis,
comprising: a plurality of groups of chips, each group designating
a component of the molecule; interlocking connectors carried by the
chips enabling them to be detachably assembled together according
to certain predetermined combinations, each combination including
two molecular strands; a plurality of lower supporting elements for
supporting the lower ends of the molecular strands; and a plurality
of upper supporting elements for supporting the upper ends of the
molecular strands; one of said plurality of supporting elements
being rotatably mounted about a vertical axis for applying a twist
to the molecular strands supported thereby; characterized in that
said plurality of lower supporting elements are supported on a
common base, and that there are at least four of such lower
supporting elements equally spaced from each other on the common
base, so that a double-strand molecule may first be constructed by
supporting the lower ends of the strands on the middle two lower
supporting elements, and then replication by mitosis may be
demonstrated by splitting the molecule into two strands, pivoting
the two strands supported on the middle lower supporting elements
so that each faces one of the remaining two lower supporting
elements, and then constructing from the two strands two
double-strand molecules.
2. A kit as defined in claim 1, wherein said lower supporting
elements comprise tightly-coiled vertical springs to be received in
sockets in the lowermost chips of the molecular strands, and
wherein said upper supporting elements are in the form of openings
to receive pins in the uppermost chips of the molecular
strands.
3. A kit as defined in claim 1, wherein the kit includes a frame
having a horizontal beam supported by and over said common base,
said horizontal beam including at least one opening therethrough;
and wherein said plurality of upper supporting elements are carried
on a horizontal bar having a vertical arm passing through said
opening in the horizontal beam of the supporting frame, said
vertical arm being rotatable in said opening to apply the twist to
the molecular strands and being fixable in a predetermined position
within the opening to fix the twist in the molecular strands.
4. A kit as defined in claim 3, wherein said horizontal beam of the
supporting frame includes three equally-spaced openings, and said
kit includes at least two of said horizontal bars, the middle
opening in the beam being used for receiving the vertical arm of
one horizontal bar to construct the double-strand molecule, and the
remaining two openings in the beam being used for receiving the
vertical arms of two horizontal bars to construct the two
double-strand molecules when demonstrating replication by
mitosis.
5. A kit as defined in claim 1 for constructing a DNA
(deoxyribonucleic acid) molecule, wherein said plurality of groups
of chips designate components of the DNA molecule and include a
group of S-chips each designating the sugar chain, a group of
P-chips each designating the phosphate chain, a group of T-chips
each designating the thymine base, a group of C-chips each
designating the cytosine base, a group of A-chips each designating
the adenine base, and a group of G-chips each designating the
guanine base; the S-chips and the P-chips including first
interlocking connectors enabling a P-chip to be attached at either
end of an S-chip and to be pivoted with respect thereto along a
first pivotable axis extending lengthwise of the S-chip; the S-chip
and the four base-chips including second interlocking connectors
enabling any one of the base-chips to be attached at one end
thereof to a mid-portion of the S-chip and to be pivoted with
respect thereto along a second pivotable axis extending widthwise
of the S-chip and at right angles to said first pivotable axis; the
four base-chips including third interlocking connectors at their
ends opposite to said one end thereof enabling said opposite end of
a T-chip to be attached to an A-chip, and said opposite end of a
C-chip to be attached to a G-chip.
6. A kit as defined in claim 5, wherein said first interlocking
pivotable connections comprise sockets formed at both ends of the
S-chips and adapted to receive pins carried at both ends of the
P-chips.
7. A kit as defined in claim 5, wherein said second interlocking
pivotable connection comprise further sockets formed in said
mid-portion of the S-chips adapted to receive pins carried at said
one end of each of the four base chips.
8. A kit as defined in claim 5, wherein said third interlocking
connections comprise two pins each terminating in a ball carried at
said opposite ends of the T-chips and A-chips, and three pins each
terminating in a ball carried at said opposite ends of the C-chips
and G-chips.
9. A kit as defined in claim 5, wherein the S-chips are each formed
with two opposed short sides joined at one end by a long straight
side at right angles to the opposed short sides, and joined at the
opposite end by two further sides forming an obtuse angle juncture
with each other at said mid-portion of the S-chip, said first
interlocking connectors of the S-chips being at said opposed short
sides, and said second interlocking connectors of the S-chips being
at said obtuse angle juncture.
10. A kit as defined in claim 9 wherein said P-chips are each in
the form of a square; said T-chips and C-chips are each in the form
of a hexagon; and said A-chips and G-chips are each in the form of
a hexagon joined at one side to a pentagon.
Description
BACKGROUND OF THE INVENTION
The present invention relates to kits for constructing DNA
(deoxyribonucleic acid) molecules and for demonstrating their
replication by mitosis.
A number of different types of kits are available for demonstrating
the construction of the DNA molecule and also its replication
during mitosis. One type, for example, uses a supporting rod and
two stretchable rubber strands, representing sugar and phosphate
chains which join the ends of the bases forming the molecule. The
stretchable rubber strands enable the molecules to be given the
double-twist characteristic of such molecules. To demonstrate
replication, the DNA molecule is assembled on a stand, and the
molecule is then split and placed on another stand for reassembling
two complete DNA molecules. Such an arrangement, however, is not
convenient in constructing the DNA molecule and also in
demonstrating replication.
SUMMARY OF THE PRESENT INVENTION
The present invention provides a kit enabling chemical molecules in
general, and DNA molecules in particular, to be constructed, and
also to be replicated, in a much more convenient manner than the
known arrangement described above.
According to the present invention, there is provided a kit for
constructing a double-strand chemical molecule having a twist
therein, and for demonstrating its replication by mitosis, the kit
comprising a plurality of groups of chips, each group designating a
component of the molecule, interlocking connectors carried by the
chips enabling them to be detachably assembled together according
to certain predetermined combinations, each combination including
two molecular strands; a plurality of lower supporting elements for
supporting the lower ends of the molecular strands; and a plurality
of upper supporting elements for supporting the upper ends of the
strands. One of the plurality of supporting elements, preferably
the upper plurality, are rotatably mounted about a vertical axis
for applying a twist to the molecular strands supported thereby.
The plurality of lower supporting elements are supported on a
common base there being at least four of such lower supporting
elements, equally spaced from each other on the common base.
The arrangement is such that a double-strand molecule may first be
constructed by supporting the lower ends of the strands on the
middle two lower supporting elements, and then replication by
mitosis may be demonstrated by splitting the molecule into two
strands, pivoting the two strands supported on the middle lower
supporting element so that each faces one of the remaining two
lower supporting elements, and then constructing from the two
strands two double-strand molecules.
The kit is particularly intended for constructing a DNA
(deoxyribonucleic acid) molecule, in which case the plurality of
groups of chips designate components of the DNA molecule and
include a group of S-chips each designating the sugar chain, a
group of P-chips each designating the phosphate chain, a group of
T-chips each designating the thymine base, a group of C-chips each
designating the cytosine base, a group of A-chips each designating
the adenine base, and a group of G-chips each designating the
guanine base. The S-chips and the P-chips include interlocking
connectors enabling a P-chip to be attached at either end of an
S-chip and to be pivoted with respect thereto along a pivotable
axis extending lengthwise of the S-chip. The S-chip and the four
base-chips include other interlocking connectors enabling any one
of the base-chips to be attached at one end thereof to a
mid-portion of the S-chip and to be pivoted with respect thereto
along a pivotable axis extending widthwise of the S-chip and at
right angles to the first pivotable axis. The four base-chips
include further interlocking connectors enabling a T-chip to be
attached to an A-chip, and a C-chip to be attached to a G-chip.
Further features and advantages of the invention will be apparent
from the description below.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention is herein described by way of example only, with
reference to the accompanying drawings, wherein:
FIG. 1 illustrates one chip of each of the component groups used in
constructing the DNA molecule; namely an S-chip designating the
sugar chain; a P-chip designating the phosphate chain; a T-chip
designating the thymine base; a C-chip designating the cytosine
base; an A-chip designating the adenine base; and a G-chip
designating the guanine base;
FIG. 2 illustrates the attachment of a C-chip to a G-chip;
FIG. 3 illustrates the use of the foregoing chips in constructing a
DNA molecule;
FIG. 4 illustrates the DNA molecule so constructed and given a
double-twist; and
FIG. 5 illustrates the construction of two DNA molecules in
side-by-side relationship to demonstrate replication by
mitosis.
DESCRIPTION OF THE PREFERRED EMBODIMENT
The kit illustrated in the drawings comprises a plurality of groups
of flat chips each group designating a component of the DNA
molecule. Thus, there are six groups of chips, one of each being
shown in FIG. 1, namely; a group of S-chips 2 each designating the
sugar chain; a group of P-chips 4 each designating the phosphate
chain; a group of T-chips 6 each designating the thymine base; a
group of C-chips 8 each designating the cytosine base; a group of
A-chips 10 each designating the adenine base; and a group of
G-chips 12 each designating the guanine base. These chips are
preferably all made of plastic material and are colour-coded to
distinguish the different groups.
The S-chips 2 are shaped according to the approximate shape of a
sugar chain, being formed with two opposed short sides 2a, 2b,
joined at one end by a long straight side 2c and joined at the
opposite end by two further sides 2d, 2e forming an obtuse angle
juncture with each other at the midportion 2' of the chip. The two
short sides 2a, 2b are each formed with a central pin-socket 22a,
22b, and the midportion 2' is formed with a third pin-socket 22c.
In addition, the S-chip carries the numbers "3" and "5" adjacent to
the sockets 22a, 22b, respectively, and the number "1" adjacent to
socket 22c, these numbers representing the carbon atoms of the
sugar chain approximately at these positions.
The P-chips 4 are of square shape to approximate the shape of the
phosphate chain, and each carries pins 24a, 24b at the centre of
two opposed sides. These pins form interlocking connectors with
sockets 22a, 22b of the S-chips 2, being snap-fitted therein when
constructing the DNA molecule.
Both the T-chips 6 and the C-chips 8 are of the same hexagonal
shape to approximate the shape of the thymine and cytosine bases,
respectively, and carry pins 26 28 centrally of one side. At the
opposite side of the respective hexagons, T-chip 6 is formed with
two spaced pins 30 each terminating in a ball 32, and C-chip 8 is
formed with three spaced pins 34 each terminating in a ball 36.
These pins represent the chemical valences of these bases.
Both the A-chips 10 and the G-chips 12 are components the form of a
hexagon joined at one side to a pentagon, thereby approximating the
shape of the chemical componets they represent. One end of each of
the two chips is formed with a pin 40, 42 respectively. The
opposite end of the A-chip is formed with two spaced pins 44, each
terminating in a ball 46, and the opposite end of G-chip 12 is
formed with three spaced pins 48, each terminating in a ball 50 to
represent the chemical valences of these bases.
Pins 24a, 24b of the P-chips 4 form an interlocking connector with
sockets 22a, 22b of the S-chips 2, enabling a P-chip to be attached
at either end of an S-chip and to be pivoted with respect thereto
along a pivotable axis extending lengthwise of the S-chip. Pins 26,
28, 40, 42 of the base chips 6, 8, 10, 12, each form an
interlocking connector with socket 22c of the S-chips 2 enabling
any one of the base chips to be attached to mid-portion 2' of the
S-chip and to be pivoted with respect thereto along a pivotable
axis extending widthwise of the S-chip, i.e., at right angles to
the first-mentioned pivotable axis of the P-chips 4. The two pins
30 and balls 32 of the T-chips 6 form an interlocking connector
with the two pins 44 and balls 46 of the A-chips 10 and permit
these two chips to be attached together at that end; whereas the
three pins 34 and balls 36 of the C-chips 8 form an interlocking
connector with the three pins 48 and balls 50 of the G-chips 12 and
permit these two chips to be attached together at that end, as
shown in FIG. 2. The rules accompanying the use of the kit may
specify that chips containing two pins and two balls may only be
attached to each other, and chips containing three pins and three
balls may only be attached to each other, although the spacing
between the pins and balls, or the shape of such spacing, may be
designed to enforce this requirement.
The kit further includes a common base 52 (FIG. 3) in the form of a
hollow box 53 for housing all the chips as well as the other parts
of the kit. The common base supports four equally spaced
tightly-coiled vertical springs 54 (two of which are shown in FIG.
3) which serve as pivotable pins receivable in sockets 22a or 22b
of the S-chips 2 in order to support the lower end of the
constructed DNA molecule. In addition, a pair of end-rods 56 are
removably attached to the base, the upper ends being bridged by a
horizontal beam 58 of rectangular section. End rods 56, which may
comprise telescoping tubes to permit disassembly, form with
bridging beam 58 a frame for supporting a bar 60, which bar
supports the upper end of the DNA molecule. For this purpose, bar
60 is formed with a pair of end openings 61 into which may be
snap-fitted the pins 24b of the P-chips 4. Bar 60 is fixed to the
lower end of a square rod 62 the upper end of which passes through
a circular opening (63) formed in beam 58. Bar 60 may thus be
rotated with respect to the vertical axis of the constructed DNA
molecule, and is fixed in its rotated position (180.degree. or
360.degree.) by means of a channel member 64 having a square
opening through which square rod 62 passes, the sides of the
channel member straddling the sides of beam 58. Thus, rod 62 and
bar 60 carried at its lower end may be raised or lowered by moving
same within the square opening of channel member 64. In addition,
the channel member may be lifted to permit the bar to be rotated,
e.g. 360.degree. to provide a double-helix in the constructed DNA
molecule, and then the bar may be locked in its rotated position by
lowering channel member so that it engages the sides of beam
58.
To construct the DNA molecule, the two centre pins 54 are first
used as shown in FIG. 3. First, a single strand is assembled of
alternating S-chips 2 and P-chips 4 by snap-fitting the pins 24a,
24b of the P-chips into sockets 22a, 22b of the S-chips. The lowest
chip is an S-chip 2 and its lowermost socket is snap-fitted into
the spring pin 54 of stand 52, whereas the top chip in the string
is a P-chip 4 and its pin is snap-fitted into one of the end
openings 61 in cross-bar 60. 10 S-chips 2 alternating with 10
P-chips 4 are thus assembled forming a single strand of 10
mucleotides. A second strand of 10 nucleotides is formed in a
similar manner between the adjacent centre pin 54 and the other end
of cross-bar 60. The sugar chains in the first strand should point
in the direction opposite to those in the second strand, i.e., the
"5" hydrogen should be down in one strand and up in the other
strand.
Next, the appropriate base chips 6, 8, 10 and 12 are assembled
between the centre sockets 22c of the S-chips 2 in both strands. As
one way of accomplishing this, a T-chip 6 is paired with an A-chip
10 by interconnecting pins 30 of one with pins 44 of the other, and
the pair is then snap-fitted into the centre sockets 22c of a pair
of aligned S-chips 2 in the two strands; similarly, a C-chip 8 is
paired with a G-chip 12 by interlocking pins 34 and 48, and the
pair is snap-fitted into the centre sockets 22c of another pair of
aligned S-chips 2 in the two strands. Another way of accomplishing
this is to attach the appropriate base chips to the S-chips of one
strand, and then of the other strand (as shown) in FIG. 3; then to
rotate the two strands to face each other; and finally to attach
together the pins 30, 34, 44, 48 of the base chips to be
paired.
After the DNA molecule is thus assembled, channel member 64 is
lifted off of beam 58, and rod 62 carrying cross-bar 60 is rotated
360.degree. to form a double helix in the DNA molecule as shown in
FIG. 4. The channel member 64 is then returned onto beam 58 to lock
the bar in this twisted condition.
During this twisting operation, it will be seen that the
interlocking connector arrangements described above permit the
P-chips to be pivoted with respect to the S-chips, and the S-chips
to be twisted with respect to the base chips. In addition, pins 54
supporting the lower ends of the DNA molecule permit some pivoting
of the S-chips, and pins 24b of the P-chips at the upper end of the
molecule permit pivoting of the P-chips.
To demonstrate replication of the DNA molecule by mitosis, the
molecule is straightened (i.e., untwisted) by reversing the process
described above. The molecule is then split in half by
disconnecting the connectors between the two base chips of each
pair between the two strands. Then, each strand is pivoted
180.degree. (to the position illustrated in FIG. 3), and two
further strands are assembled between the end pins 54 of the common
base. The original cross-bar 60 including its supporting rod 62 and
locking channel member 64 is moved over to one side of the frame
and is used for assembling one of the new DNA molecules, and a
second cross-bar 60' including rod 62' and locking channel member
64' is used for assembling the second DNA molecule.
Many variations, modifications and other applications of the
illustrated embodiment will be apparent.
* * * * *