U.S. patent number 3,800,798 [Application Number 05/270,640] was granted by the patent office on 1974-04-02 for hydrophobic catheter construction.
Invention is credited to Alvin L. Winkler.
United States Patent |
3,800,798 |
Winkler |
April 2, 1974 |
HYDROPHOBIC CATHETER CONSTRUCTION
Abstract
A catheter construction having a hydrophobic inner surface
adapted to provide extended blockage-free use. The inner surface is
defined by a coating of hydrophobic silicon dioxide. The coating
may be adhered to the catheter tubular wall by heat fusion,
adhesive, etc., means. In one heat fusion method, the inside
surface of the catheter tubing is heated while maintaining the
remainder of the tubing at relatively low temperature to maintain
the tubular integrity thereof while bonding the hydrophobic
material to the heated wall surface. In another method of producing
the catheter, powdered hydrophobic material is packed in the tubing
and the packed tubing is suitably treated to effect the desired
coating whereupon the remaining particulate material is removed
from the tubing as by fluid flow therethrough. In still another
method of forming the catheter construction, the tubing and coating
may be effectively concurrently formed.
Inventors: |
Winkler; Alvin L. (Oak Lawn,
IL) |
Family
ID: |
23032174 |
Appl.
No.: |
05/270,640 |
Filed: |
July 11, 1972 |
Current U.S.
Class: |
604/266;
138/145 |
Current CPC
Class: |
A61L
29/106 (20130101); A61M 25/0045 (20130101); A61M
25/0009 (20130101); A61M 25/007 (20130101); A61M
25/0032 (20130101) |
Current International
Class: |
A61M
25/00 (20060101); A61L 29/00 (20060101); A61L
29/10 (20060101); A61m 025/00 () |
Field of
Search: |
;128/348,349R,349B,349BV,350,351,239,DIG.21 ;138/145,146 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Truluck; Dalton L.
Attorney, Agent or Firm: Hofgren, Wegner, Allen, Stellman
& McCord
Claims
I claim:
1. A catheter construction providing extended blockage-free use,
comprising:
a flexible tubular catheter element having an inlet opening at one
end for receiving body fluids and an outlet opening at the opposite
end for discharging body fluids, said catheter being formed of
elastomeric polymeric material; and
a physiologically compatible coating effectively retained on the
inner surface of said tubular catheter of hydrophobic Silanox.
2. The catheter construction of claim 1 wherein said tubular
catheter element is formed of vinyl thermoplastic resin.
3. The catheter construction of claim 1 wherein said tubular
catheter element is formed of latex rubber.
4. The catheter construction of claim 1 wherein the outer surface
of the catheter element adjacent said inlet opening is provided
with said hydrophobic coating.
5. The catheter construction of claim 1 wherein the outer surface
of the catheter element is provided with said hydrophobic
coating.
6. The catheter construction of claim 1 wherein said coating is
thermally bonded to said catheter element.
7. The catheter construction of claim 1 wherein said coating is
adhesively bonded to said catheter element.
8. The catheter construction of claim 1 wherein a polyurethane
coating is provided on said inside surface of the catheter element
and said hydrophobic coating is provided on the inside surface of
said polyurethane coating.
9. The catheter construction of claim 1 wherein said tubular
catheter element is formed of a synthetic thermoplastic resin.
10. The catheter construction of claim 1 wherein said tubular
catheter element is provided with a thermally set adhesive coating
on said inner surface and said hydrophobic material is bonded to
said catheter element.
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to catheter constructions and in particular
to catheter constructions arranged to provide extended
blockage-free use.
2. Description of the Prior Art
Catheters have long been utilized for draining body fluids and the
like. One such common use is in the draining of urine. It has been
found that in such uses the conventional catheter constructions
tend to block up after a period of time requiring removal of the
catheter and either removal of the blockage or insertion of a
replacement catheter. Such operations are painful, time consuming,
and possibly injurious to the patient, and it is, therefore, a
desideratum that effectively maximum blockage-free operation of the
catheter be obtained to minimize the need for such removal and
replacement.
A number of different catheter materials have been employed in an
effort to find a catheter construction which would provide
substantially extended blockage-free use. None of the known
catheter constructions, however, have been fully satisfactory in
solving this vexatious problem.
SUMMARY OF THE INVENTION
The present invention comprehends an improved catheter construction
which provides substantially extended blockage-free use solving
this longstanding vexatious problem in a novel and simple
manner.
More specifically, the invention comprehends providing on the inner
surface of a plastic tubular catheter a hydrophobic coating of
silicon dioxide, effectively avoiding a blockage of the catheter
passage by deposited material such as urine salts. The catheter
tubing may be formed of an elastomeric polymeric material such as a
vinyl plastic, latex rubber, etc. The hydrophobic coating may be
effectively retained on the catheter tubing by a number of
different methods so as to provide a water repellent pellent
surface defined by microscopic projections having interstitial air
capillaries. The liquid tends to be carried on the projections to
maintain a body of air in the interstitial spaces.
One improved method for applying the hydrophobic silicon dioxide
comprehends extruding the tubing of synthetic thermoplastic resin
or rubber latex and flowing a stream of hydrophobic silicon dioxide
material against the inner surface of the extruded tubing so as to
effect a heat fusion of the hydrophobic material thereto and as a
result of the heat energy of the extruded tubing. The tubing may be
concurrently exteriorly cooled and delivery of the flowed
hydrophobic material may be suitably spaced from the point of
extrusion of the tubing so as to cause impingement of the material
on the tubing inner surface at a point where the temperature is a
preselected fusion bonding temperature.
Alternatively, the hydrophobic material may be packed in
particulate form in previously formed tubing and the packed tubing
subjected to heat or heat and pressure, such as steam pressure, to
effect the desired fusion bonding to the inner surface. The excess
powdered material is then removed such as by blowing the material
outwardly from the tubing to complete the manufacture.
Another method of forming the coating comprises dipping the
completed catheter tubing material in a liquid carrying the
hydrophobic material and allowing the liquid vehicle to evaporate
to effect the desired bonded coating deposition.
Alternatively, the coating may be adhered to the tube surface by
adhesive bonding methods. Illustratively, an adhesive may be flowed
through the tubing to provide a coating on the inside surface
thereof and the hydrophobic material subsequently flowed through
the adhesively coated tube to provide the coating deposit. The
hydrophobic material may be flowed in a body of cool air to effect
a setting of the adhesive. Further alternatively, the hydrophobic
material may be packed in the adhesive coated tubing and subjected
to a setting heat, as in an oven, to effect the desired set
bond.
Where the tubing is formed with the coating prior to the
manufacture thereof into the catheter construction, the portions of
the catheter construction not so coated, such as the tip or outside
surface of the tube, may be subsequently treated as by any of the
above methods to complete the coating of all desired surfaces with
the hydrophobic material .
BRIEF DESCRIPTION OF THE DRAWING
Other features and advantages of the invention will be apparent
from the following description taken in connection with the
accompanying drawing wherein:
FIG. 1 is a fragmentary side elevation illustrating one method of
applying the hydrophobic coating to a catheter tube;
FIG. 2 is an enlarged transverse section taken substantially along
the line 2--2 of FIG. 1;
FIG. 3 is a fragmentary side elevation illustrating the coating of
an end portion of the catheter construction;
FIG. 4 is a fragmentary side elevation with portions shown in
diametric section illustrating another method of coating the
catheter tubing;
FIG. 5 is an isometric view shown with a portion broken away
illustrating another method of providing the catheter construction
coating;
FIG. 6 is a fragmentary side elevation with portions shown in
diametric section illustrating still another method of coating the
catheter tubing;
FIG. 7 is an isometric view with a portion broken away illustrating
still another method of providing the catheter construction
coating;
FIG. 8 is a fragmentary side elevation illustrating still another
method of providing the catheter construction coating; and
FIG. 9 is a transverse section of the catheter construction coated
tube.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In the exemplary embodiments of the invention as disclosed in the
drawing, a catheter construction generally designated 10 is shown
to include a flexible tubular catheter element 11 provided with a
coating 12 on the inner surface 13 of the tubular catheter element.
The coating comprises a coating of hydrophobic material providing
improved liquid flow through the passage 14 of the catheter to
effectively provide extended blockage-free use of the catheter such
as in draining of body fluids.
More specifically, the hydrophobic material may comprise a fumed
silicon dioxide material providing a rough outer surface which
cooperates with the hydrophobicity provided by the chemical nature
of the material to minimize the wetting of the coating surface by
liquids such as aqueous solutions and more specifically, body
fluids. The fumed silicon dioxide provides microscopic projections
which tend to support the water on the tips of the projections so
as to provide open spaces between the tips and thereby providing
substantially increased hydrophobic characteristics of the coating.
The coating preferably exhibits a contact angle with water of
between approximately 125.degree. and 150.degree.. While a number
of different hydrophobic materials may be utilized providing such
hydrophobicity, it has been found that an excellent material for
this purpose is that identified as Silanox marketed by Cabot
Corporation, of Boston, Massachusetts, and comprising a fumed
silicon dioxide reacted with a silane to define the following
molecular structure: ##SPC1##
Such Silanox material is marketed under the grade identification of
Silanox 101 and has the following physical characteristics:
Appearance -- Superfine, fluffy white powder
Surface area -- 225m.sup.2 /gm (BET)
Primary particle size -- 7 m.mu.
Bulk density -- 3 lbs./cu. ft.
325 mesh residue -- 0.02%
*pH -- 8-10
Specific gravity -- 2.2
X-ray structure -- Amorphous
*4% dispersion of Silanox 101 in 50% IPA/50% water.
The fumed silicon dioxide may be produced by the hydrolysis of
silicon tetrachloride in a flame process to produce a silicon
dioxide material which is nonporous, amorphous, of high chemical
purity, and of large specific surface area. The particles are
sintered into long, branched, submicron sized aggregates which are
then reacted with the silane material to replace hydroxyl groups
with hydrophobic hydrocarbon groups.
It has been unexpectedly found that by providing a low wetting
characteristic to the inner surface of a tubular catheter, a
substantially blockage-free characteristic of the catheter is
obtained, permitting extended retention of the catheter in the body
orifice and avoiding the need for periodic removal and replacement
of the catheters as has been required in the past with conventional
catheter constructions. Thus, it has been found that not only does
the provision of the hydrophobic coating 12 on catheter surfaces 13
provide for facilitated flow of the body fluids through the
catheter for facilitated removal of the body fluids from the
patient, but also provides synergistically a blockage-free
operation eliminating the vexations and serious problem of required
periodic replacement of the conventional catheters.
The catheter construction of the present invention may be formed in
a number of novel manners. More specifically, as shown in FIGS. 1
and 2, a tube 15 of suitable catheter material may be extruded from
a conventional extruder 16 through a head 17. Concurrently with the
extrusion of the tube 15, Silanox material may be directed against
the inner surface 18 of the tube by means of a nozzle 19 projecting
coaxially through extrusion head 17 and provided with a plurality
of radial passages 20. The material may be urged outwardly from the
nozzle 19 by means of a pressurized fluid, such as air, which may
be relatively cool so as to cause the setting of the Silanox
material on the tube surface 18 in the form of a thin coating 21.
Thus, the coating may be bonded to the tube surface 18 by a fusion
bonding action as a result of the thermal energy of the extruded
tube 15. The outer surface 22 of the tube may concurrently be
cooled by directing cooling air thereagainst by means of an air
flow structure 23. Thus, the coated tube may be quickly set in the
desired final configuration with the coating of hydrophobic
material permanently bonded to the inside surface.
In forming the completed catheter construction, a tip portion 24
may be secured to one end of a cut length of the coated tube, as
shown in FIG. 3, and the tip provided with a coating of the
hydrophobic material as by dipping the tip in a fluidized bed 25
thereof. Alternatively, the tip 24 may be heated by suitable
heating means and merely dipped into a body of powdered hydrophobic
material to effect the desired bonded coating.
As shown in FIG. 4, the catheter may further include a connecting
portion 26 attached to the opposite end of the tube 15. As further
shown in FIG. 4, the coating of the inner surface 18 of the tube
may be provided by packing the powdered hydrophobic material in the
tube upon completion of the connection of tip portion 24 and
connecting portion 26 thereto as by injecting the material
thereinto by means of a suitable injector nozzle 27. Upon filling
of the passage with the hydrophobic material, the tip openings are
suitably closed as by taping and the powder compacted by vibrating
the assembly. Alternatively, the powder may be compacted by
centrifuging the assembly with the tip outermost. The packed tube
may then be suitably heated as by placement in a suitable oven 28,
as shown in FIG. 7, to fuse the coating layer 12 to the tube inner
surface. The powdered hydrophobic material remaining unbonded to
the tube surface is then suitably removed as by passing a stream of
air through the catheter to complete the manufacturing operation.
As shown in FIG. 8, a suitable air nozzle 29 may be inserted into
the connector portion 26 of the catheter to blow cool air through
the catheter and thereby quickly set the coating 12.
Still another method of manufacturing the catheter construction 10
is to place the tube 15 with the tip 24 and connector 26 attached
thereto in a body of liquid 30 in a suitable tank 31. Liquid 30 may
comprise a solution of the coating material in a volatile vehicle
and a small percentage of binder. Upon removal of the structure
from the tank, the vehicle may be suitably evaporated leaving the
desired bonded coating thereon.
Still further, as shown in FIG. 6, the hydrophobic material may be
secured to the tube wall surface 18 by firstly applying a layer of
suitable bonding material or adhesive to the surface 18 by
injecting the adhesive into the catheter through a suitable
injection nozzle 32 as shown in FIG. 6. The hydrophobic material
may then be passed through the tube to form a coating thereof on
the layer 33 of adhesive material previously deposited. The
adhesive is then caused to set to complete the manufacture. The
provision of the hydrophobic material in the adhesive coated tube
may be effected by the packing of the material therein, as shown in
FIG. 4, with the subsequent removal of the excess nonbonded
hydrophobic material as by flowing air through the tube, as shown
in FIG. 8.
Specific examples of methods of forming the catheters are as
follows:
EXAMPLE I
A vinyl tube was packed with hydrophobic Silanox material and
vibrated in a vertical position to compact the material uniformly
throughout the tube. The tube was then heated for a period of 20
minutes in an oven heated to a temperature of 340.degree. F. The
tube was then removed and allowed to cool to room temperture
whereupon the loose Silanox material was removed by passing an air
stream therethrough.
EXAMPLE II
A vinyl tube was packed with hydrophobic Silanox material and
vibrated in a vertical position to compact the material uniformly
throughout the tube. The tube was then heated for a period of 20
minutes in an autoclave in a steam atmosphere at 340.degree.F.
under a pressure of 35 p.s.i. The tube was then removed and allowed
to cool to room temperature whereupon the loose Silanox material
was removed by passing an air stream therethrough.
EXAMPLE III
A vinyl tube was packed with hydrophobic Silanox material and the
material then compacted with a rod. The tube was then heated for a
period of 10 minutes in an oven heated to a temperature of
340.degree.F. The tube was then removed and allowed to cool to room
temperature whereupon the loose Silanox material was removed by
passing an air stream therethrough.
EXAMPLE IV
A tube was coated with a film of adhesive by passing a solution of
5% thermoplastic polyurethane polymer in 95% methyl ethyl ketone,
the polyurethane polymer comprising a No. 5715 B. F. Goodrich Co.
Estane material. The tube was then filled with the hydrophobic
Silanox material and vibrated in a vertical position. The packed
tube was then heated to 200.degree.F. for a period of 20 minutes.
The tube was then removed and allowed to cool to room temperature
whereupon the loose Silanox material was removed by passing an air
stream therethrough.
EXAMPLE V
A vinyl tube was coated with a film of adhesive by passing a
solution of 50% thermoplastic polyurethane polymer in 50% benzene,
the polyurethane polymer comprising B. F. Goodrich Co. Vulcalock
material, and dried for 12 hours. The tube was then filled with the
hydrophobic Silanox material and vibrated in a vertical position.
The packed tube was then heated to 200.degree.F. for a period of 20
minutes. The tube was then removed and allowed to cool to room
temperature whereupon the loose Silanox material was removed by
passing an air stream therethrough.
EXAMPLE VI
A latex rubber tube was coated with a film of adhesive by passing a
solution of 50% thermoplastic polyurethane polymer in 50% benzene,
the polyurethane polymer comprising B.F. Goodrich Co. Vulcalock
material, and dried for 12 hours. The tube was then filled with the
hydrophobic Silanox material and vibrated in a vertical position.
The packed tube was then heated to 200.degree.F. for a period of 20
minutes. The tube was then removed and allowed to cool to room
temperature whereupon the loose Silanox material was removed by
passing an air stream therethrough.
EXAMPLE VII
A latex rubber tube was packed with hydrophobic Silanox material
and vibrated in a vertical position to compact the material
uniformly throughout the tube. The tube was then heated for a
period of 20 minutes in an autoclave in a steam atmosphere at
370.degree.F. under a pressure of 37 p.s.i. The tube was then
removed and allowed to cool to room temperature whereupon the loose
Silanox material was removed by passing an air stream
therethrough.
EXAMPLE VIII
A latex rubber tube was coated with a film of adhesive by passing a
solution of 5% thermoplastic polyurethane polymer in 95% methyl
ethyl ketone, the polyurethane polymer comprising a No. 5715 B. F.
Goodrich Co. Estane material. The tube was then filled with the
hydrophobic Silanox material and vibrated in a vertical position.
The packed tube was then heated to 200.degree.F for a period of 20
minutes. The tube was then removed and allowed to cool to room
temperature whereupon the loose Silanox material was removed by
passing an air stream therethrough.
The adhesive materials may be modified to vary the thickness
thereof. Further, the Silanox may be dissolved in suitable adhesive
materials so as to provide both the bonding and hydrophobic
materials in a single layer. The treating of the tubing in a
liquid, as shown in FIG. 5, may comprise a step of utilizing
bonding material as the liquid 30 and subsequently treating the
bond coated structure with the powdered hydrophobic material. In
the embodiment of FIG. 4, the nozzle 27 may provide the powdered
hydrophobic material in a stream of hot air which effects the
desired heating of the inner surface 18 of the tube to permit
adherance and bonding of the carried hydrophobic material thereto
with a continuous flow of the hot air stream through the tubing.
Such a method of coating the tubing presents an advantage in that
the entire tube is not heated and thereby maintains the tubular
configuration.
Alternatively, hot air can be passed from the nozzle 27 prior to
flowing of the powdered material therethrough so as to effect a
preheating of only the inner surface portion 18 with the powdered
material being delivered subsequently thereto at a relatively low
pressure and at a lower temperature. As soon as sufficient material
is adhered to the surface 18, a stream of cool air may be flowed
through the tube to complete the setting of the coating.
The foregoing disclosure of specific embodiments is illustrative of
the broad inventive concepts comprehended by the invention.
* * * * *