U.S. patent number 3,794,028 [Application Number 05/336,222] was granted by the patent office on 1974-02-26 for method for injecting chemicals into the papilla for depilation.
Invention is credited to Amos C. Griffin, Robert C. Mueller.
United States Patent |
3,794,028 |
Mueller , et al. |
February 26, 1974 |
METHOD FOR INJECTING CHEMICALS INTO THE PAPILLA FOR DEPILATION
Abstract
The invention disclosed provides a method of depilation in human
mammal by injecting a dose of chemical depilatory solution into
hair follicle such to permanently destroy hair growth at that
location. Injection of the chemical depilatory solution may be
effected by means of a hypodermic syringe for penetrating beneath
the skin surface and for dispensing effective dosage amounts of the
depilatory solution into the follicle.
Inventors: |
Mueller; Robert C. (Houston,
TX), Griffin; Amos C. (Houston, TX) |
Family
ID: |
23315100 |
Appl.
No.: |
05/336,222 |
Filed: |
February 27, 1973 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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175068 |
Aug 26, 1971 |
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Current U.S.
Class: |
604/506; 606/133;
8/161 |
Current CPC
Class: |
A61M
5/00 (20130101) |
Current International
Class: |
A61M
5/00 (20060101); A61b 017/00 (); A61m 005/00 () |
Field of
Search: |
;128/215,216,303.18,335,355 ;8/161 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Medbery; Aldrich F.
Attorney, Agent or Firm: Brown; Laurence R.
Parent Case Text
This application for U. S. letters Pat. is a continuation-in-part
of application Ser. No. 175,068, filed Aug. 26, 1971, now
abandoned.
Claims
What is claimed is:
1. A method of permanently destroying hair growth within a hair
follicle of a living mammal comprising the steps of inserting the
needle end of a hypodermic syringe to disperse a minute dosage of
chemical depilatory solution non-toxic to the biological system
beneath the skin into the follicle alongside the hair to be
destroyed, dispensing said chemical depilatory solution within the
hair follicle to reach the vicinity of the papilla, and withdrawing
said needle immediately after dispensing said solution.
2. The method as defined in claim 1, wherein in said insertion step
the needle end of said hypodermic syringe is inserted to a depth of
about 3 to 4 mm. within said hair follicle.
3. The method as defined in claim 2, wherein in said insertion step
the needle end of said hypodermic syringe enters the region of the
papilla.
4. A method of depilation in human mammal comprising the steps
of,
choosing as a dose a controlled amount of a selectively acting
depilatory chemical solution non-toxic to the biological system of
the mammal for adequately reacting with the hair forming structure
to destroy it,
injecting the dose of depilatory solution into the hair follicle
beneath the skin surface, and
permitting said solution to remain in the follicle until the
chemical reaction with the hair forming structure is completed, the
controlled quantity thereby limiting the possibility of
inflammation.
5. The method defined in claim 4, wherein the solution is a soda
solution.
6. The method defined in claim 4, wherein the solution is a
chemical that reacts with Keratin.
7. The method defined in claim 4, wherein the depth of insertion is
controlled and the solution is metered in amount and strength to
effect chemical reaction only in a limited region about the
papilla.
8. The method defined in claim 4, wherein the solution is about
0.01 N to about 0.10 N sodium hydroxide solution.
9. The method defined in claim 4 wherein the amount of solution
injected is about 1 to about 5 microliters.
Description
The present invention relates to a method of depilation in human
mammal and more particularly to depilation by injecting a dose of
chemical depilatory solution into hair follicile beneath the skin
surface.
In the present method, an appropriate depilatory solution
containing hydrolyzing and/or reducing agents is disposed in direct
contact with hair follicle by inserting a hypodermic syringe needle
into the follicle and discharging an effective dosage of the
depilatory solution.
Depilation is the well known process by which hair is removed by
chemical degradation of the hair keratin. This is in contrast to
epilation, wherein the hair is removed substantially intact.
One of the early depilatory compositions known in the prior art is
that described in U.S. Pat. No. 707,955, in which a composition
consisting of sulphur, hypersulfite of soda and oil of turpentine
is disclosed for use in weakening or permanently preventing growth
of hair on the human body. This composition was applied to the skin
where it remained for an appropriate time, after which the
composition was removed in a suitable manner. Several applications
were required at intervals of a few days to permanently destroy the
hair roots or follicles.
A number of additional chemical depilatory compositions are also
known to the art which destroy exposed portions of the hairshaft.
Examples of such compositions include additives based on stannites,
thioglycolates, alkaline sulfides of sodium and lithium; sulfides
and sulph-hydrates of alkali and alkaline earth metals;
dimethylamines and the like. Such depilatories are applied directly
to the skin, and thus are able only to destroy hair at skin
level.
Epilatory compositions, such as wax and rosin, are well known in
the art. These compositions are applied commonly in combination
with a bandage or pad for effecting hair removal. However, these
compositions do not produce desired results of permanently
destroying the hair root, thus preventing any further growth of the
hair at that location.
A known method of permanently destroying the hair root is through
electrolysis. In electrolysis treatment, an instrument is used
which includes a self-contained source of electric energy having a
small needle of about 5 mils. in diameter at one end. This needle
is inserted through the skin alongside the hair to be removed and
is maintained in contacting engagement with the papilla vascular
connective process which nourishes the hair root. Contacting
engagement is maintained for a predetermined number of seconds
while the needle is electrically activated, after which the needle
is withdrawn. The hair is thus permanently destroyed and may be
manually pulled out of location. The electrical energy working in
the papilla permanently destroys any tendency for future growth of
hair. This operation is continued hair-by-hair over the area of the
skin desired to be treated.
The electrolytic process is based on decomposing the natural sodium
chloride of the organism by the generation of current which
accumulates soda within the follicle. The soda is the medium which
destroys the hair and prevents any future growth at that location.
This type of electrolytic treatment may cause pain to the person
being treated when supplying electric energy inside the body.
Practice of the present invention will become more apparent by
reference to the drawing wherein there is diagrammatically
illustrated injection of a depilatory into the papilla by a
hypodermic needle. Needle 5 of hypodermic syringe 6 is inserted
through the skin 7 alongside hair 8, to be removed. The needle is
inserted to a depth of about 3 to 4 mils. or a depth sufficient to
insert a depilatory solution, such as soda, into follicle 9 such
that the solution can reach the region of the papilla 10.
The extent of chemical reaction in the region of the papilla by the
injected solution can be controlled by the concentration of the
solution, having just enough selectively acting chemicals to finish
the process of killing the hair-forming structure before being used
up in chemical reaction. The chemistry of the reaction which takes
place within the hair follicle to permanently kill the hair may be
that described in detail hereinafter.
The papilla 10 has root contacts 11 which communicate with the body
flood vessels to nourish the hair. It is in this region that the
depilatory solution serves to permanently destroy the capacity of
the hair to regrow. Thus, the depilatory solution serves not only
to attack the hair fiber itself, but also the hair nourishment
structure. Preferably, therefore, the injected solution is limited
to the region of the papilla to permit the hair to be chemically
attacked only at the end. Thus, the root end of the hair may be
permanently killed by chemical action and then may be pulled out of
the follicle 9 by the external hair portion. Pulling of the hair
for removal may be by wiping or pulling action at some later time.
Removal leaves little decomposed hair fiber within the papilla, as
would necessarily result by the surface skin treatment methods and
thus, limits the possibility of infection or inflammation.
In accordance with this invention, therefore, a number of
advantages may be realized. For example, human hair may be
completely converted to a soft, plastic mass which is easily
removed from the skin by wiping or rinsing. Also, the present
method permits non-toxic hair removal of the biological system and
non-irritation of the skin.
A depilatory solution may be thus readily applied at each desired
follicle through a hypodermic syringe economically, and with no
pain such as is experienced by application of electrical
energy.
In the chemical reaction, Keratin, the protein to which hair
largely owes its characteristic physical properties, is
particularly high in the sulphur containing amino acid, cystine
(about 17%). Cystine, in turn, is linked chemically with other
non-sulphur amino acids, including aspartic and glutamic acids. The
disposition of the sulphur in the hair fiber becomes such as to
form a sulphur-to-sulphur bridge between polypiptide chains (R) :
CH.sub.2 -S-S-CH.sub.2 -R. The kind and arrangement of these amino
acid residues in juxtaposition to cystine seemingly govern the
degree of protection or the vulnerability of the S-S (disulfide)
linkage to attach by chemical agents since all S-S linkages in
human hair are not equally reactive. Mostly, chemical treatment of
hair involves rupture and reformation of S-S linkages, which, under
normal condition, confer stability and flexibility to the hair
fiber. Whereas it is most important to prevent complete breakdown
of all crosslinking disulfide bonds in a permanent waving process,
it is the objective of chemical depilation to cleave sufficient S-S
indiscriminately so that the hair will readily disintegrate for
removal and the like linkages of the papilla are permanently
destroyed. Under the influence of such different chemical agents as
alkali, metal sulfides and sulfites, cyanides, amines, mercaptans
and certain metal salts, the S-S bond in Keratin is affected;
increasing osmotic pressure develops within the hair fiber which
swells, loses its tensile strength, and generally deteriorates. A
mass of jelly-like consistency which can be easily removed by
wiping or scraping is the final stage of the alkaline hydrolysis in
the presence of a reducing agent. Both the outer layer (cuticle)
and inner color-bearing layer (cortex) are disintegrated.
An example of the effect of alkali on S-S linkages is as follows:
##SPC1##
Also, addition of organic bases, such as methylamines and
dimethylamines, monoethanolamine, ethylenediamine, hydroxylamine,
hydrazine, guanidine, aminoguanidine, and piperidine accelerate the
dehairing effect of hydroxide suspensions. In general, alkaline
degradation involves first the rupture of cystine linkages between
main polypeptide chains, then progressing under more drastic
treatment to hydrolyses of main polypeptide chains. The process is
dependent on concentration of hydroxyl ions, temperature and time
of reaction.
The disulfide linkges in Keratin can be broken by chemical
reduction which is analogous to the reduction of cystine to
cysteine: ##SPC2##
This process is independent of R radical; reduction of S-S
groupings in Keratin with aliphatic thiols, sulfides, bisulfites or
cyanides; occurs in neutral, or better, in alkaline media through
nucliophiltic attached radical displacement; or by an ionic
mechanism.
The sulfides of Li, Na, K, CS, Mg, Ca, Sr, Ba, Al, As and Sn
accelerate dehairing in the presence of calcium hydroxide
suspensions. These depilatory formulations involve no unusual
health hazard in skin surface treatments, and may be considered
similarly safe when used in the present invention. The use of soda
solution, for example, produces the effect caused by electrolysis,
which has been used safely for many years. Moreover, use of the
present method wherein the depilatory solution is placed into the
hair follicle avoids the problem encountered when using cream or
paste depilatories wherein the necessarily high pH's of the
formulation hinders removal of hair below the skin by swelling the
skin until openings of the hair follicles are constricted such that
the alkali cannot get in and the hair root cannot get out.
The following examples are illustrative of the various chemical
depilatory solutions that may be used in accordance with the
teachings of the invention:
EXAMPLE I
Percent By Ingredient Weight Potassium Sulfide 10 Propylene Glycol
11.5 Alcohol (Ethyl) 4 Water 73 Menthol 0.2 Perfume 1.0 Sodium
Carboxymethyl cellulose (low viscosity) 0.3
EXAMPLE II
Percent By Ingredient Weight Sodium Sulfide 10 Glycerin 10 Alcohol
(Ethyl) 5 Water 73 Benzocaine 0.3 Menthol 0.2 Perfume 1.5
EXAMPLE III
Percent By Ingredient Weight Calcium Thio- glycolate 8
Propyleneglycol 11 Carbowax 6000 (trademark for polyethylene
glycols by Union Carbide Corp.) 4 Alcohol (Ethyl) 6 Water 70
Perfume 1.0 Ammonium Hydroxide 10
EXAMPLE IV
Percent By Ingredient Weight Dimethylamine 4.0 Glycerin 10 Water 80
Tween 20 (trademark for polyoxyethylene derivatives of fatty acid
partial esters of hexitol anhydrides By Atlas Chemical Co.) 5
Perfume 1.0
EXAMPLE V
Percent By Ingredient Weight Sodium Sulfide 10 Sorbitol 9 Water 74
Atlas G-2160 (trademark for a polyoxyethylene oxypropylene stearate
containing emulsifier by Atlas Chemical Co.) 6 Perfume 1.0
EXAMPLE VI
10% by weight caustic soda solution
EXAMPLE VII
The present method was performed on a 53 year old caucasian
volunteer. A section of the lateral left forearm (2 .times. 2 cm)
was chemo-epilated in the following manner. Using an especially
prepared micro-syringe, 1.0 microliter portion of a 0.1 N NaOH
solution was injected into the base of the follicles through the
follicular oriface. The hair was then mechanically removed and the
follicles were marked for later identification with a ball point
pen. 24, 48 and 72 hours later, representative follicles were
biopsied using a 2 mm dermal punch with local anesthesia. The
specimens were then submitted for histological examination by
serial sections and hematoxalin and eostin staining.
Patient discomfort and post-treatment reaction was minimal. The
results of this test showed permanent, non-scarring epilation.
In practicing the present method, the depilatory solution may be
administered by inserting a minute dose into each follicle to be
destroyed by injection under the skin alongside the hair to reach
the vicinity of the papilla with a hypodermic needle, as shown in
the drawing. Typically, an effective dosage for use herein is about
1 to about 5 microliter quantities of 0.01 N and 0.1 N sodium
hydroxide solution or the equivalent thereof. In this way, an
economical, effective depilation method is provided which may
utilize the skills of technicians now employing electrolysis for
depilation, since the needles are inserted in the region of the
papilla in a similar manner, but the sometimes painful step of
introducing the electric current is eliminated.
The hair growth is, therefore, permanently destroyed in accordance
with this invention by inserting a depilatory solution under the
skin into the follicle in the region of the papilla with a
hypodermic syringe. The needle of the syringe is immediately
withdrawn after injecting the depilatory solution so that the
method is faster than electrolysis aand more effective. Hairs may
be removed after processing by pulling or wiping without the
necessity of letting solutions be in contact with large areas of
skin for long periods of time.
The chemicals used are selectively operable to attach the protein
hair fiber of Keratin and to cause little reaction with other body
tissue. In any event, the dosage is so small and may be so
controlled by metering a given amount of a solution of given
concentration that any reaction or damage to other tissue is
confined to a small region adjacent the papilla.
Accordingly, the state of the depilation art is improved by the
method of this invention with unexpected advantages of less pain,
less time, less chance of inflammation and infection, and more
effective permanent destruction of life of the hairs treated.
It is to be understood that the foregoing detailed description is
given merely by way of illustration and that many variations may be
made therein without departing from the spirit of this
invention.
* * * * *