U.S. patent number 3,790,048 [Application Number 05/276,196] was granted by the patent office on 1974-02-05 for incremental dose dispenser.
This patent grant is currently assigned to Ortho Pharmaceutical Corporation. Invention is credited to Gustav V. Borden, Robert A. Luciano, Chester M. Zmijewski.
United States Patent |
3,790,048 |
Luciano , et al. |
February 5, 1974 |
INCREMENTAL DOSE DISPENSER
Abstract
A dispenser is provided for use in conjunction with syringes and
is capable of accurate, rapid dispensing of small incremental doses
and rapid and convenient refilling of the syringe. The dispenser
comprises an elongated plunger for engaging and advancing the
piston of the syringe to expell liquid doses therefrom. The plunger
is threaded along at least a portion of its longitudinal,
peripheral surface. A drive wheel is provided for advancing the
plunger; the drive wheel having its peripheral surface divided into
alternate threaded sections and longitudinal separating grooves.
The threaded sections engage the threaded portions of the plunger
advancing the same to rapidly dispense the incremental doses. The
longitudinal grooves provide a clearance between the plunger and
drive wheel thereby leaving the plunger disengaged for rapid
refilling of the syringe.
Inventors: |
Luciano; Robert A. (Warren,
NJ), Zmijewski; Chester M. (Martinsville, NJ), Borden;
Gustav V. (Warren, NJ) |
Assignee: |
Ortho Pharmaceutical
Corporation (Raritan, NJ)
|
Family
ID: |
23055599 |
Appl.
No.: |
05/276,196 |
Filed: |
July 28, 1972 |
Current U.S.
Class: |
222/390; 74/128;
604/211; 604/223; 222/391; 604/224 |
Current CPC
Class: |
A61M
5/31553 (20130101); A61M 5/31585 (20130101); Y10T
74/1529 (20150115); A61M 5/3156 (20130101); A61M
5/31593 (20130101); A61M 5/31575 (20130101) |
Current International
Class: |
A61M
5/20 (20060101); A61M 5/315 (20060101); A61m
005/22 () |
Field of
Search: |
;222/390,391
;128/218R,218A ;74/126,128 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Reeves; Robert B.
Assistant Examiner: Kocovsky; Thomas E.
Attorney, Agent or Firm: Jason Lipow et al.
Claims
1. A dispenser for delivering a controlled dose of liquid from a
syringe having a liquid containing cartridge open at one end and a
piston for expelling the liquid through the open end of the
cartridge, said dispenser comprising:
a. a housing;
b. an elongated plunger, reciprocally mounted on said housing,
having means at one end for engaging said piston, and being
threaded along at least a portion of its longitudinal peripheral
surface;
c. a cylindrical drive wheel for advancing said plunger, rotatably
mounted to said housing, said drive wheel being threaded along its
peripheral surface, said threads being interrupted by radially
spaced grooves cut into the peripheral surface and extending
parallel to the axis of said drive wheel and separating said
threads into radially spaced threaded sections;
d. said drive wheel being mounted, relative to said plunger, so
that it may be rotated to alternatively bring said threaded
sections and said grooves into register with said plunger, the
threaded sections when brought into register with said plunger,
engaging the threads of said plunger and the grooves when brought
into register with said plunger providing a clearance between said
drive wheel and said plunger; and
e. actuating means for rotating said drive wheel through at least
one threaded section and from registry with one separating groove
to registry with any separating groove, thereby advancing said
plunger and said piston, said rotation ending with said plunger
disengaged from said drive
2. The dispenser of claim 1 provided with preselecting means for
selecting the number of threaded sections through which said
actuating means will
3. The dispenser of claim 2 wherein said preselecting means
comprise:
a limiting pin mounted on said depressible element and projecting
therefrom in the direction of depression;
a cylindrical section barrel, rotatably mounted on said housing,
and having a face opposing and spaced apart from said limiting pin
when said depressible element is in the undepressed state;
said opposing face provided with a plurality of radially spaced
bores;
said selection barrel being mounted with respect to said limiting
pin so that each of said bores may be selectively brought into
register for receiving said limiting pin by rotating said selection
barrel, whereby the degree of reciprocal travel of said depressible
element is limited by the depth of each bore, each bore having a
depth limiting the degree of said depressible element travel to
corresponding to a rotation of said drive
4. The dispenser of claim 1 wherein said actuating means
comprise:
a depressible element, reciprocally mounted to said housing;
translating means for translating the reciprocating motion of said
depressible means to rotary motion; and
5. The dispenser of claim 4 wherein said translating means
comprise:
a cam pin mounted on said depressible element and adopting the
reciprocal motion thereof;
a cam barrel, rotatably mounted on said housing and having a
helical cam way cut therein for receiving said cam pin and, by cam
action, converting the reciprocating motion of said cam pin into
rotary motion of said cam
6. The dispenser of claim 5 wherein the transmitting means
comprise:
a cam barrel drive shaft, integral with said cam barrel;
a driving element of a two-part ratchet, integral with said drive
shaft; and
the driven element of the two-part ratchet, integral with said
drive wheel;
said cam barrel, said drive shaft, said driving element, said
driven element, and said drive wheel all being coaxially aligned.
Description
This invention concerns liquid dispensers and particularly those
designed to be used in conjunction with syringes and capable of
dispensing accurate, incremental doses, each of which is only a
small fraction of the total capacity of the syringe. Such
dispensers are especially useful in laboratory work where a task
frequently involves the rapid and accurate dispensing of many small
incremental doses of a reagent from a storage supply such as a
prefilled syringe. In such work, it is frequently necessary to
refill the syringe after the supply is depleted and then continue
to dispense the small accurate doses. Heretofore, no device has
been available to smoothly perform the transition between accurate,
rapid dispensing of small doses and rapid and convenient refilling
of the syringe.
In accordance with this invention, a liquid dispenser is provided
for use with a syringe having a liquid-containing cartridge, open
at one end, and a piston, generally slidably mounted in the
cartridge, for expelling the liquid out of the open end. The
opening is usually fitted with a cannula for accurately directing
the flow of liquid to the desired delivering point.
The dispenser of this invention comprises a housing and, mounted
thereon and in reciprocating relationship thereto, an elongated
plunger having means at one end for engaging the piston of the
syringe so as to advance it and expell liquid therefrom. The
plunger is threaded along at least a portion of its elongated
peripheral surface. A cylindrical drive wheel, for advancing the
plunger, is rotatably mounted to the housing. The drive wheel is
threaded along its peripheral surface, the threads being
interrupted by radially spaced grooves cut into the peripheral
surface and extending parallel to the axis of the drive wheel.
Thus, the peripheral surface presents a plurality of alternating
threaded sections and separating grooves. The drive wheel is
mounted on the housing, relative to the plunger, so that it may be
rotated to, alternatively, bring the threaded sections and the
separating grooves into register with the threaded portion of the
plunger. Further, the threaded section of the drive wheel and the
threaded portion of the plunger engage when they are in register
and advance the plunger as the drive wheel is rotated. The grooves,
on the other hand, are of sufficient depth to provide a clearance
between the plunger and drive wheel when they are in the register.
Actuating means are provided for rotating the drive wheel through a
preselected degree of rotation, the degree of rotation, however,
selected so as to always terminate with a groove of the drive wheel
in register with the threads of the plunger (i.e., with the plunger
disengaged from the drive wheel by virtue of the clearance between
the threaded section of the plunger and the drive wheel).
In operation, as the drive wheel passes through a degree of
rotation corresponding to one threaded section in engagement with
the plunger, the plunger will advance reciprocally a discrete
incremental distance. This, in turn, will advance the piston of the
syringe the same incremental distance and hence dispense a
controlled incremental dose of liquid. By preselecting the degree
of rotation of the drive wheel to correspond to any number of
threaded sections, the plunger may be advanced a desired multiple
of increments and a dose, of the size corresponding to multiple
increments, may be delivered.
In accordance with this invention, the preselected degree of
rotation always terminates with the threaded portion of the plunger
in register with a groove on the drive wheel. Thus, by virtue of
the clearance between the groove and the plunger, the dispenser is
always in a disengaged state after each dose has been dispensed,
i.e., the plunger free to move, reciprocally to any extent with-out
having to actuate the rotating mechanism. A user may, therefore,
dispense any number of doses, each of a preselected size, and then,
after a series of dose dispensing, the user may freely move the
plunger, so as to fill or empty the syringe.
A better understanding of the invention will be had by referring to
the appended drawings, illustrating a specific embodiment of the
invention, as taken together with the following description.
Referring now to the drawings:
FIG. 1 is a perspective view of a dispenser embodying this
invention as used in conjunction with a syringe;
FIG. 2 is a longitudinal, partial section taken along line 2--2 of
FIG. 1;
FIG. 3 is a transverse, partial section taken along line 3--3 of
FIG. 2; and
FIG. 4 is an exploded, perspective view of a portion of the
dispenser and syringe shown in FIG. 1.
As best shown in FIG. 1, a dispenser 10 is provided with a
gun-shaped housing 12 having an arm 14 for supporting a syringe 16.
The syringe comprises a cartridge 18 for containing a supply of a
liquid, the cartridge terminating in an opening 20 having, fitted
therein, a cannula 22 for accurately directing the flow of liquid
to the desired delivery point. Externally accessible, depressible
means, illustrated in the drawing, by a trigger 24, is provided for
actuating the dispenser, and a selection wheel 26 is provided for
selecting the size of the dose corresponding to one full actuation,
i.e., one full depression of the trigger. The housing 12 is also
provided with an arm 28 for supporting a plunger (not shown in FIG.
1) which engages the piston of the syringe (also not shown in FIG.
1). The arm 28 has a slot 30 running longitudinally therewith
through which a projection 32, integral with the plunger, extends
for manually repositioning the plunger. In operation, the size of a
given dose is preselected, by rotating the selection wheel. The
trigger is then depressed, activating the dispenser and advancing
the plunger and the piston of the syringe so as to dispense the
preselected dose.
Referring now to FIGS. 2, 3, and 4, the plunger 34 as illustrated,
reciprocally mounted to the housing 12, and provided with means for
engaging the piston 36, said piston being slidably mounted in the
cartridge 18 of the syringe 16 so as to be capable of advancing and
expelling liquid contained within the cartridge through the cannula
22. The engagement means shown comprise a small projection 38
extending collinearly from the end of the plunger and having a
circumferential bead 40 for snap-fitting into a corresponding bore
42 provided in one end of the piston 36.
The plunger comprises an elongated member having threads 44 on a
portion of its longitudinal peripheral surface. As best shown in
FIGS. 2 and 3, surfaces of the plunger 46, and 48 are preferably
flattened and contained against corresponding surfaces 46', and 48'
of the housing to prevent rotation of the plunger in operation and
to limit movement of the plunger to reciprocal motion. Thus, as
assembled, the plunger, the piston and the syringe cartridge are
each co-aligned and collinear with the reciprocating motion of the
plunger.
A drive wheel 50, for advancing the plunger is rotatably mounted to
the housing and is provided with threads 52, cut into its
peripheral surface. These threads are interrupted by radially
spaced grooves 54, extending parallel to the axis of the drive
wheel. Thus, as best viewed in cross-section in FIG. 3, and in
perspective in FIG. 4, the peripheral surface of the drive wheel
displays a plurality of radially spaced, alternating threaded and
grooved sections.
The drive wheel is rotatably mounted in the housing so that the
threaded sections 52 may be rotated into register and engage the
threaded portion of the plunger. In this position of engagement,
the plunger can only be advanced by rotation of the drive wheel,
the extent of the advance being determined by the degree of
rotation of the drive wheel and the pitch length of the threads.
For example, when the threads of the drive wheel have a pitch
length equal the the threads of the plunger, the plunger will move
reciprocally one pitch length per thread-engaged revolution. On the
other hand, if the wheel is rotated through only one fifth of the
revolution, the plunger will advance a distance equal to 0.2 times
the pitch length. For the specific embodiment illustrated in the
drawings, the drive wheel comprises five equal, radially spaced,
grooves 54. The pitch length is chosen so that rotation of the
drive wheel through one threaded section will advance the plunger
and hence, the engaged piston of the syringe, a distance equivalent
to one incremental dose. A rotation of the drive wheel through two
threaded sections will deliver a dose equal to two increments.
Similarly, a three, four and five incremental dose may be delivered
by corresponding rotation of the drive wheel through a
corresponding number of threaded sections. As will be more fully
described below, means are provided for actuating the device to
rotate the drive wheel through a pre-selected number of thread
sections per actuator and hence deliver a preselected dose size per
actuation.
Irrespective of the number of threaded sections selected to be
rotated in engagement with the plunger per actuation, at the end of
each actuation, the drive wheel rotation terminates with a
longitudinal groove in register with the threads of the plunger. As
best viewed in FIG. 3, the longitudinal grooves are cut to a depth
sufficient to provide a clearance 56 between the threads of the
plunger and the drive wheel when the grooves and the plunger are in
register. By virtue of this clearance, the plunger is then free to
move reciprocally after every rotation. Thus, in accordance with
this invention, the drive wheel may be actuated repeatedly to
deliver repeated doses, each of a pre-selected size. At the end of
each delivery, the plunger is completely disengaged from the drive
wheel and may be manually repositioned by gripping the projection
32 and sliding the plunger. Thus, for example, at any time the
syringe may be refilled and the plunger will be immediately ready
to deliver further incremental doses. To insure that the threads
will mesh, as the threaded section of the wheel is rotated into
engagement with the threads of the plunger, bearing plate 58 is
provided, urged into contact with the plunger by a spring 60.
As mentioned above, means are provided for actuating the device by
rotating the drive wheel through a preselected degree of rotation.
Such means comprise the trigger 24, for depressing once per
actuation and a spring 62, to thereafter return the trigger to its
original, undepressed position. Translating means are provided for
translating the reciprocating motion of the depressing trigger into
a rotary motion for rotating the drive wheel. The translating means
comprise a cam pin 64 mounted to the trigger and hence adopting the
reciprocating motion of the trigger when depressed. The cam pin
cooperates with a cam barrel 66, rotatably mounted to the housing
and having cut therein, a helical camway 68 in which the cam pin
travels reciprocally and, by cam action, rotates the cam barrel.
Transmitting means are provided for transmitting the rotary motion
of the cam barrel to the drive wheel. These transmitting means
comprise, in serial, coaxial alignment: a cam barrel drive shaft
70; integral therewith, the driving element 72 of a two-element
ratchet; and, integral with the drive wheel 50, the driven element
74 of the ratchet. The cam barrel, the cam barrel drive shaft and
the driving element of the ratchet all rotate when the trigger is
either depressed or repositioned by the action of spring 62. The
two elements of the ratchet co-engage by means of teeth 75, slanted
so as to cause the driving element, when rotated, as when the
trigger is depressed, to rotate the driven element 74 in a
direction corresponding to the advancement of the plunger. On the
other hand, when the driving element is rotating in the opposite
direction, as when the trigger is repositioned by the action of the
spring 62, the teeth 75 will slip past each other and the driven
element 74 will not rotate. To allow for such slippage, the driving
element 72 of the ratchet is mounted on the end of the cam barrel
drive shaft 70 so as to be limitedly slidable, with a spring 76
provided to supply sufficient tension to urge the teeth of the two
elements to co-engage when the trigger is depressed, the spring
also being sufficiently yieldable to allow the driving element to
slide back on the cam barrel drive shaft when the trigger returns
to the undepressed position by the action of the spring 62.
As described above, the size of the dose delivered per actuation of
the device, i. e., per depression of the trigger, is determined by
the degree of rotation of the drive wheel. Stated in other words,
the dose size is determined by the number of threaded sections of
the drive wheel rotated in engagement with the thread plunger.
Because of the coaxial alignment of the cam barrel, cam barrel
drive shaft, ratchet and drive wheel, the degree of rotation of the
drive wheel is determined by the degree of one full rotation of the
cam barrel; rotation of the cam barrel in the advancing direction
of the plunger will produce a full rotation of the drive wheel. The
degree of rotation of the cam barrel, in turn, is a function of the
extent of travel of the cam pin in the cam way. In the embodiment
illustrated in the drawings, means are provided for setting the
travel of the cam pin to a preselected limit and hence preselecting
the size of the dose per actuation. These means comprise a limiting
pin 78 mounted on the trigger and projecting therefrom in the
direction of trigger travel. The limiting pin cooperates with a
selection barrel 80, rotatably mounted on the housing and having a
face 82 opposing, and spaced apart from, the limiting pin. The
selection barrel is provided, on the face of the barrel opposing
the limiting pin, with a series of radially spaced bores 84 of
varying depth. Each of the bores may be selectively brought into
register for receiving the limiting pin by rotating the selection
barrel.
When any one of the bores is brought into register, the extent of
travel of the trigger when fully depressed is limited to the
distance between the projecting end of the limiting pin and the
bottom of the bore. Accordingly, by rotating the selection barrel
into register with a selected bore, the degree of travel of the
trigger, the degree of rotation of the drive wheel and hence, the
dose size may be selected. In the embodiment illustrated in the
drawings, the depth of the shallowest bore is sized to correspond
to a degree of rotation of the drive wheel equal to rotating the
drive wheel through one threaded section 52 from one longitudinal
groove 54 to the next. Accordingly, when selectively registering
the shallowest bore, the device will dispense a dose of an
incremental size equivalent to the plunger and piston advancement
resulting from rotating the one threaded section 52 of the drive
wheel in engagement with the threads of the plunger. The deepest
bore corresponds to rotating the drive wheel through one full
rotation, i. e., five threaded sections 52, and hence by
registering this bore, the device will dispense a five-fold
incremental dose. Stated generally, the selection barrel is
provided with a bore of a depth limiting the degree of trigger
travel, to that corresponding to a rotation of the drive wheel
through a preselected number of threads sections on the drive
wheel.
It will be apparent to one skilled in the art that the actual
volume of a single incremental dosage, i. e., a dosage equivalent
to rotating the drive wheel through one threaded section, is a
function of such factors as the pitch length selected for the
threads, the number of threaded sections per revolution, and the
volume displaced in the syringe by a limited length of piston
travel. The device may be designed to delivery any of a wide range
of incremental dose sizes. For example, a device dispensing a one
micro-litre incremental dose may be designed by using a syringe
having an inside diameter of 1/8-in. in combination with a drive
wheel, threaded with five sections and using a pitch length of
0.025 inches for both the threads on the drive wheel and the
threads on the plunger. With this combination, the device is
capable of alternatively delivering doses of 1, 2, 3, 4 or 5
microlitres per actuation.
The dispenser of this invention may be made from various materials
of construction known to those skilled in the art and limited only
by such economic considerations as the cost of raw material, the
ease of manufacture, and the durability of parts, when taking into
consideration the repeated usage of the dispenser. For example, a
preferred method of manufacture is the well-known injection molding
technique using various materials and composites such as ABS
(acrylonitrude, butadiene and styrene), Noryl (polycarbonate), or
reinforced nylon. Metals, capable of being machined, such as
aluminum, stainless steel or brass are also suitable.
While the dispenser of this invention and the methods for making
and using the same have been described in terms of specific
embodiments and illustrations, it will be apparent to one skilled
in the art that various changes may be made in form, construction
and arrangement of parts without departing from the scope and
spirit of the invention. Accordingly, the scope and spirit of the
invention should not be restricted except as defined in the
accompanying claims.
* * * * *