U.S. patent number 3,780,936 [Application Number 05/215,482] was granted by the patent office on 1973-12-25 for mixer-separator for automated analytical chemistry system.
This patent grant is currently assigned to The United States of America as represented by the Secretary, Department. Invention is credited to Ian E. Bush.
United States Patent |
3,780,936 |
Bush |
December 25, 1973 |
MIXER-SEPARATOR FOR AUTOMATED ANALYTICAL CHEMISTRY SYSTEM
Abstract
A mixer-separator unit for use in automated analytical chemistry
systems wherein two liquid phases are brought into intimate contact
and then separated. The two liquids are put into a vessel where
slow rotation slops them around in the vessel to secure intimate
mixing. Fast rotation is begun after a preset interval which
results in fast and efficient centrifugal separation of the phases.
After another interval tap jets are opened to withdraw the denser
phase and then the lighter phase.
Inventors: |
Bush; Ian E. (Plainview, L. I.,
NY) |
Assignee: |
The United States of America as
represented by the Secretary, Department (Washington,
DC)
|
Family
ID: |
22803157 |
Appl.
No.: |
05/215,482 |
Filed: |
January 5, 1972 |
Current U.S.
Class: |
494/1; 494/12;
494/59; 494/43; 494/84 |
Current CPC
Class: |
B04B
5/0442 (20130101); B04B 11/04 (20130101); B04B
1/10 (20130101) |
Current International
Class: |
B04B
5/04 (20060101); B04B 1/00 (20060101); B04B
11/00 (20060101); B04B 11/04 (20060101); B04B
5/00 (20060101); B04B 1/10 (20060101); B04b
001/14 (); B04b 011/06 () |
Field of
Search: |
;233/19R,19A,2R,2A,47R,21,22,46 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Krizmanich; George H.
Claims
I claim:
1. A mixer-separator including
a base, said base having a side at some angle with the
horizontal;
rotation means mounted on the side, said rotation means having an
axis of rotation;
a mixing vessel attached to the rotation means and rotatable about
the axis of rotation thereby, said mixing vessel including fluid
holding means;
valveless ejection means for separating one liquid from another
liquid, said means being carried by said mixing vessel and
communicating with the fluid holding means for controlling the
retention of liquid therein, when said ejection means is in a first
position, and the withdrawal of liquid therefrom, when said
ejection means is in a second position, said ejection means
including an outlet means, the outlet means being a first axial
distance from the axis of rotation when said ejection means is in
the first position, the first axial distance being less than the
axial distance from the axis of rotation to the circumference of
the inner cylindrical surface of the liquid in the position it
assumes during centrifugal separation, and a second axial distance
from the axis of rotation when said ejection means is in the second
position, the second axial distance being greater than the axial
distance from the axis of rotation to the circumferences of the
inner and outer cylindrical surface of the liquid in the position
it takes during centrifugal separation; and
collection means for collecting the ejected liquid.
2. The device of claim 1 wherein the rotating means is a motor
which runs at more than one speed.
3. The device of claim 2 wherein the mixing vessel is essentially
in the shape of a truncated cone with its small end attached to the
rotating means.
4. The device of claim 3 wherein said fluid holding means is an
interior chamber of said mixing vessel, said interior chamber being
of a shape substantially corresponding to the shape of said mixing
vessel.
5. The device of claim 2 wherein the mixing vessel is essentially
in the shape of a truncated cone with its larger end attached to
the rotating means.
6. The device of claim 5 wherein said fluid holding means is an
interior chamber of said mixing vessel, said interior chamber being
of a shape substantially corresponding to the shape of said mixing
vessel.
7. The device of claim 1 wherein said valveless ejection means
includes a flexible tube connecting the fluid holding means with
the outlet means.
8. The device of claim 1 further including means for moving said
valveless ejection means between the first and second
positions.
9. The device of claim 1 wherein said valveless ejection means is
rotatably connected to said mixing vessel.
10. The device of claim 9 further including means for rotating said
valveless ejection means between the first and second
positions.
11. The device of claim 10 wherein said means for rotating said
valveless ejection means includes gears.
12. The device of claim 1 wherein said outlet means is a
tap-jet.
13. The device of claim 1 wherein said collection means includes a
splash board, said splash board substantially enclosing said mixing
vessel and said valveless ejection means.
Description
The present invention relates to liquid mixer-separators and, more
particularly, to liquid mixer-separators which bring two liquid
phases into intimate contact and then separates them.
An analytical procedure in chemistry consists of a series of
operations carried out in a fixed sequence which may be considered
as steps or stages. At first sight the variety of such procedures
suggests that their generalization would be difficult. Several
existing systems are based on a series of units arranged in a
linear series connected by tubing for transport of samples and
reagents, and activated by time delay programming switches of the
type common in domestic washing machines. They depend on the fact
that many simple analytical procedures, especially in clinical
chemistry, involve a simple and standardized sequence of
operations. Different procedures can be obtained merely by varying
the reagents mixed with the sample; the time sequence of operations
remaining the same.
The disadvantages of such types of apparatus are numerous, the main
ones being as follows: First, each set (or channel) of the
equipment has to be set aside for one procedure per batch of
samples. In order to carry out several procedures in parallel it is
necessary to purchase and run many channels, involving large
capital outlays and much waste of investment when channels are out
of use or being converted to a new procedure. Second, they are
unable to carry out efficiently certain operations which are common
in analytical procedures for trace-substances: e.g. liquid-liquid
extraction and washing, evaporation of bulky extracts, filtering,
and chromatographic extraction or fractionation.
The basic idea of the new systems, of which the present invention
is one of the components, is that all analytical procedures can be
boiled down to sets of stages whose logical structure is uniform.
This uniformity of each stage immediately suggests two features of
a generalized apparatus for automated analytical chemistry;
A. The information content of an analytical procedure is relatively
small and amenable to a very simple type of computer
programming.
B. The means by which samples and reagents are transported through
the system is the most important feature of the system. Thus, all
stages of an analytical procedure consist effectively of two
standard sub-stages.
1. Bring sample and reagents into a "vessel" or "operant unit"
designed to carry out a certain operation;
2. Carry out unit operation.
The sample may be the original sample in the usual sense or a
derived fraction of it resulting from previous stages of the
procedure. To emphasize this it will be called the "reactant" or
"reactant phase" in the following description. The important thing
is that most of the information content of sub-stage (2) is
contained in the mechanical properties of the apparatus or unit
used for each stage. The transportation sub-stage (1) can be
defined simply by the types of units involved--namely the next
operant unit in the sequence and the types of reagent supply units
to be marshalled into the operation.
The number of different types of units is not too large and can be
worked out in terms of the phases involved in each operation. At
the boundaries of the system a large number of physical measuring
instruments can be attached but usually only one or a few of each
type are needed.
The system arising from this analysis is essentially a matrix of
about 10 types of operant units connected by a transportation
system capable of passing reactants and reagents rapidly between
any and all pairs of units in the matrix.
With the above background information relative to the problems and
proposals of automated analytical chemistry systems in mind, it is
obvious that there exists a great need for efficient and reliable
components to carry out these systems. One such essential
component, and perhaps the most important, is a mixer-separator
unit which forms the subject matter of the present invention; this
mixer-separator automatically functions to bring together two
liquids, to mix them together in intimate contact, and then to
automatically separate them.
The device of the present invention can be controlled by computer,
and offers a great improvement over comparable units which are
expensive, clumsy, and very slow in performance. The present
invention through the expedient of slow rotation slops the two
liquids around in a vessel until they are intimately mixed, then a
fast rotation is begun which results in separation of the liquids
by centrifugal action. At a proper interval, suitable taps or
valves are opened to permit the liquids to flow out of the
vessel.
It is accordingly, an object of the present invention to overcome
the deficiencies of the prior art, such as indicated above.
Another object of the present invention is the provision of an
efficient mixer-separator for liquids.
Another object of the present invention is the provision of a
mixer-separator which may be controlled by a computer.
Yet another object of the invention is the provision of a
mixer-separator which may be used in an automated analytical
chemistry system.
Still another object of the invention is the provision of a
mixer-separator which permits individual withdrawal of the liquids
after they have been separated.
Other objects and many of the attendant advantages of the present
invention will be readily appreciated as the same becomes better
understood by reference to the following detailed description when
considered in connection with the accompanying drawings in which
like reference numerals designate like parts throughout the figures
thereof and wherein:
FIG. 1 is a sectional view of a preferred embodiment of the
invention;
FIG. 2 shows a modification of the invention;
FIG. 3 shows another modification of the invention;
FIG. 4 shows another view of the modification of FIG. 3; and
FIG. 5 shows a method of opening and closing the
mixer-separator.
Referring now to the drawings there is shown in FIG. 1, which
represents a preferred embodiment of the invention, a
cross-sectional view of the mixer-separator. There is provided a
base 10 of substantially triangular configuration, one leg of which
serves as a foundation and the hypotenuse of which forms a plane
about 30.degree.-45.degree. with the horizontal. Securely fastened
to the hypotenuse side of the base is an electric motor 11 having a
drive shaft 12 extending outwardly from the base. A mixing vessel
substantially in the shape of a truncated cone is attached to motor
drive shaft 12 at it's smaller end so that the entire vessel is
rotated by the motor 11.
Positioned across the larger outer end of vessel 13 is a lid 14
which is securely fastened to the vessel 13, the center of the lid
having a tubular shaped portion 15 connecting with the inner area
of the vessel and comprising an input channel for the admittance of
fluids to such vessel 13. Over the entire mixing vessel 13 and its
connections is a cover 16 which joins the base 10, the cover 16
being of relatively heavy gage material as a safety feature for
protection of personnel when the device is being spun particularly
at high speed by motor 11. The outer end of the tubular channel 15
extends through the cover 16 and has its edges beveled to assist in
the admittance of fluid to the vessel. A collar 17 forms a part of
lid 16, and with its associated ball bearings 18 provides a
rotating support for the outer end of the tubular channel 15.
Also extending through the lid 16 are two dowel pins 20 and 21,
having L-shaped arms 22 and 23 which contact a sleeve 24 enclosing
the upper part of channel 15. The free ends of arms 22 and 23 work
in two vertical grooves and a partial spiral slot (not shown) in
sleeve 24 as will be more fully described hereinafter. Pivotally
mounted on either side of the channel 15, by means of pins 25 and
26, are two small gears 27 and 28, these gears 27 and 28 serving as
means for turning two movable arms 30 and 31. Through the center of
each of the movable arms 30 and 31 there is provided, respectively,
a channel 32 and 33 ending in tap-jets 34 and 35, while connected
at the other ends of such channels are two short pieces of flexible
tubing 36 and 37. Tubing 36 is fastened to a connection 38 through
the lid 14 and into vessel 13 while tubing 37 is fastened to a
connection 40. A circular splash board 41 is located near vessel 13
and a drain plug 42 connects the top half of the mixer- separator
with the hollow area of the base 10.
In FIG. 2, there is shown another-embodiment of the invention.
Here, as in FIG. 1, there is a triangular shaped base 10, with the
hypotenuse at a slight angle to the horizontal, and a motor 11
integrally fastened to this hypotenuse. It is obvious, however,
that in this embodiment the truncated, cone-shaped, mixing vessel
13 has been reversed so that now the larger end is downward and
fastened to the drive motor 11. The smaller end does not require a
lid, but there is provided a port for the admission of fluids to be
mixed by the unit. The tap-jets 43 and 44 have a slightly different
configuration in that they take the form of two-position rotary
valves. In FIG. 2 tap-jet 43 is shown in the off position while
tap-jet 44 is in the on, or open, position to permit withdrawal of
fluid from the vessel. To operate tap-jet 43 there is provided a
valve arm 45 which is activated by a U-shaped bracket 46. When the
bracket 46 is moved up and down (by means either manual or
automatic, not shown) the outer end of valve arm 45 moves in the
bracket to rotate the circular valve part of the tap-jet and
thereby align a channel 47 through the valve with a drain hole 48
in the side of vessel 13, or to block the drain hole as the case
may be. By like analysis, tap-jet 44 has a valve arm 50 which moves
within a bracket 51 to align or block channel 52 with drain hole
53.
In the embodiment shown in FIGS. 3 and 4, the mixer-separator has
it's mixing vessel 13 in the shape of a flattened oval rather than
a truncated cone, and the tap-jets for withdrawing fluid are
connected to the sides of the oval, and extend around the sides and
over the back to meet with drain pipes external to the mixer
itself.
Turning now to FIG. 5 there is shown a top view of the mechanism
for withdrawing fluid from the embodiment of FIG. 1., with the
tap-jets in both the open and closed positions. In place of the
taps 43 and 44 of FIG. 2, flexible chemically inert tubes 36 and 37
are connected to a plain outlet at each end of one of the diameters
of the rotor and these pass upward and then inwardly through small
movable arms 30 and 31, ending in a bend which provides short
outlet jets 34 and 35. The position of arms 30 and 31 is controlled
either by gearing, such as the gears 27 and 28 in the illustrated
embodiment, or by a variety of conventional cams or connecting
rods. The central gear 60, cam, or connecting rod rotor is mounted
on a sleeve 24 enclosing the upper shaft of the main centrifugal
rotor. Rotary movement of this gear 60, etc. is provided by a
further sleeve 61 containing two diametrically opposed dowel pins
20, 63 and 64 which work in two vertical grooves 65 and 66 on the
main shaft of the rotating tubular channel 15 and a partial spiral
slot [not shown] in the sleeve 24. These dowel pins 63 and 64 are
mounted in sleeve 6 in contact with a thrust bearing so that
movements of this bearing in the direction of the axis of the main
rotor can be achieved during high speed rotation of the latter. The
vertical movement of dowel pins 20 and 21 causes the corresponding
vertical movement of sleeve 61 and pins 64 and 65 which work in the
vertical grooves 65 and 66 of the tubular channel 15 and the spiral
slot in sleeve 24. The vertical movement of pins 64 and 65 in the
spiral slot, therefore, rotate the sleeve 24 and hence the central
gear 60 with respect to the rotor and in turn moving rocker arms 30
and 31 from the closed position to the open position. In the closed
position, the outlets of the tubes are within the circumference of
the inner cylindrical surface of the body of liquid in the position
it takes under the centrifugal force of high speed rotations. Under
these circumstances, no ejection of fluid takes place. In the open
position, the outlets are at the circumference of the main rotor so
that ejection takes place into a collector ring similar to the
previous modifications positioned at the appropriate height.
As to the operation of the device the two liquids which are to be
mixed are inserted in the mixing vessel 13 through the tubular
opening 15, and the motor 11 is turned on at slow speed. This slow
rotation slops the two liquids around in the vessel to secure
intimate mixing. After a preset interval fast rotation of motor 11
is begun which results in rapid and efficient centrifugal
separation of the phases. After a safe interval the two tap-jets 34
and 35 are deflected to the open position by means of gearing 27
and 28 (or valves 43 and 44 are opened by the movement of brackets
46 and 51 in FIG. 2). Since the heavier liquid making up the denser
phase will be ejected first, when the tap-jets are opened this
denser phase is ejected through jets 34 and 35 and against splash
board 41 to be withdrawn by drain plug 42. The interface with the
lighter phase is sensed by an electronic transducer (not shown)
which, via appropriate circuitry, again opens the tap-jets, and
this time the lighter liquid is ejected. The version shown in FIG.
3 has a conventional take-off head using tubes and a specially
machined grooved head as in a continuous flow centrifuge or
cream-separator.
From the above description of the structure and operation of the
present invention it is obvious that the device offers many
improvements over the weaknesses and shortcomings of prior
mixer-separators. The invention provides for the thorough and
intimate mixing of two liquids and then the fast and efficient
centrifugal separation of the dense and lighter phases. The device
may be readily used in an automated analytical chemistry system,
and is adaptable for control by a computer.
Obviously many modifications and variations of the present
invention are possible in the light of the above teachings. It is
therefore to be understood, that within the scope of the appended
claims, the invention may be practiced otherwise than as
specifically described.
* * * * *