U.S. patent number 3,779,371 [Application Number 05/234,064] was granted by the patent office on 1973-12-18 for package of separated materials to be mixed.
This patent grant is currently assigned to Century Laboratories, Inc.. Invention is credited to Walter M. Rovinski.
United States Patent |
3,779,371 |
Rovinski |
December 18, 1973 |
**Please see images for:
( Certificate of Correction ) ** |
PACKAGE OF SEPARATED MATERIALS TO BE MIXED
Abstract
A package in which two materials maintained in separated
relation can be mixed and dispensed in which a liquid is preloaded
in one member and a material to be taken up in the liquid in
another member and the two members are joined to form a package in
which the materials are maintained in their separated relation but
in which the liquid can be transferred from the one member to the
other without member separation for taking up the other material in
solution or suspension.
Inventors: |
Rovinski; Walter M.
(Turnersville, NJ) |
Assignee: |
Century Laboratories, Inc.
(Turnersville, NJ)
|
Family
ID: |
22879740 |
Appl.
No.: |
05/234,064 |
Filed: |
March 13, 1972 |
Current U.S.
Class: |
206/221; 215/6;
604/90; 604/416 |
Current CPC
Class: |
A61J
1/2089 (20130101); A61J 1/201 (20150501); A61J
1/2037 (20150501); A61J 1/2044 (20150501) |
Current International
Class: |
A61J
1/00 (20060101); B65d 081/32 () |
Field of
Search: |
;206/47A,63.5 ;215/6
;128/218M,272 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Dixson, Jr.; William T.
Claims
I claim:
1. A package of measured amounts of two materials, at least one of
which is a liquid, in which the materials are maintained in a
separated relation in the package until substantially immediately
prior to use and are admixed while still in the package from which
the mixture of materials can be poured comprising a vial in the
form of a test tube having an opening only at the top containing a
measured amount of a material to be mixed with the liquid, a
tubular member having a neck portion at the forward end with a
passage extending continuously therethrough from the open rearward
end to the open forward end, said tubular member being dimensioned
to have a forward wall to wall dimension which is less than the
wall to wall dimension of the vial, a sealing member on the neck
portion of the tubular member dimensioned to engage the walls of
the vial in sealing engagement when the tubular member is inserted
in the open end portion of the vial as a stopper, sealing means
closing the passage through the tubular member at the forward end
portion to separate the passage of the tubular member from the
material in the vial in normal position and to provide an open
passage communicating the interior of the vial with the passage
upon actuation to operative position in response to pressure from
the liquid in the tubular member, a piston ring dimensioned
slidably to be received in the passage of the tubular member, and
means for actuating the piston ring from normal position in the
rearward end of the passage to operated position in the forward end
portion of the passage to force the liquid from the tubular member,
the liquid in the tubular member being maintained in sealing
relation within the tubular member between the sealing means and
the piston ring.
2. A package as claimed in claim 1 in which the sealing means on
the neck end portion of the tubular member comprises a diaphragm
spanning the open end of the passage at the forward end of the
tubular member and having a passage which remains closed while the
diaphragm is in normal position and which opens responsive to
flexure of the diaphragm in response to liquid pressure from within
the tubular member.
3. A package as claimed in claim 1 in which the sealing means
comprises a sealing ring of flexible material within the forward
end portion of the passage through the tubular member but rearward
of the neck portion, and means for opening a passage through the
sealing ring responsive to internal pressure from the liquid in the
tubular member.
4. A package as claimed in claim 3 in which the sealing ring is
formed with a slit through the central portion thereof which
remains closed when in normal position and which opens in response
to flexure of the ring in response to fluid pressure.
5. A package as claimed in claim 2 in which the passage in the
diaphragm is in endwise alignment with the end portions of the
tubular member for abutment with the neck flange to effect a
sealing relation therewith when in normal seated position.
6. A package as claimed in claim 1 in which the sealing means
comprises a sealing ring of flexible material within the forward
end portion of the passage through the tubular member but rearward
of the neck portion, a diaphragm extending crosswise of the sealing
ring to seal off the passage, a support extending crosswise within
the passage between the diaphragm and the shoulder formed by the
neck portion of the tubular member and which engages the shoulder
as a stop, a bayonet fixed to the support with the pointed end
extending in the direction of the diaphragm for piercing the
diaphragm responsive to internal fluid pressure.
7. A package as claimed in claim 2 in which the sealing member and
diaphragm are of unitary construction of a flexible sealing
material.
8. A package as claimed in claim 3 in which the sealing ring is
formed of an elastomeric material having circular ribs dimensioned
to extend into sealing engagement with the inner wall of the
tubular member.
9. A package as claimed in claim 1 which includes means on the
rearward end of the piston ring for attachment of an actuator and
which includes an elongate actuator dimensioned to exceed the
length of travel of the piston ring through the tubular member.
10. A package as claimed in claim 9 in which the actuator comprises
an elongate rod dimensioned to be received in telescoping relation
within the tubular member and with means for attachment of the
actuator to the piston ring.
11. A package as claimed in claim 1 which includes flange members
extending radially outwardly from the rearward end portion of the
tubular member for use as a finger grip.
12. A package as claimed in claim 3 in which the sealing ring
comprises a unitary disc member having a central body portion and
rim portions of greater thickness than the central body
portion.
13. A package as claimed in claim 3 in which the sealing ring
comprises a pair of axially spaced rim portions, a tubular portion
joining the inner areas of said rim portions and a disc portion
spanning the tubular portion with a slit therethrough.
Description
This invention is addressed to a package in which two materials can
be maintained in separated relation and from which the material can
be dispensed after intermixing.
There are a number of applications, primarily in the chemical and
pharmaceutical arts, where it is desirable to combine two materials
in a predetermined ratio but where the materials cannot be premixed
in the desired ratio to provide a stock solution because of the
instability of the mixture or solution. Under such circumstances,
it is necessary that such admixture be effected almost immediately
prior to use.
This means that the materials must be kept separated one from the
other until immediately prior to admixture. When made available in
separate containers, error can arise with respect to removal of
specified amounts of materials for admixture in the desired ratio.
This means that separate containers for each of the materials must
be provided as well as a container for admixture and it means
further that contamination can take place during the separate
handling of the materials and their admixture in a separate
container.
Devices of the type illustrated in U. S. Pats. No. 3,464,414, No.
3,198,194, and No. 2,695,614 have been provided in which a single
container is divided into separate compartments by means of a plug
seated in a restricted portion between the compartments, with a
view towards sealing the compartments one from the other. The plug
is adapted to be displaced from the restricted portion into the
lower compartment in response to fluid pressure to enable the
material in the one compartment to flow into the other through the
freed constricted portion connecting the compartments.
This construction is faced with a number of problems, such as
providing an effective seal to prevent transmission of vapors from
one compartment to the other and it is faced further by the
contamination by the plug which is displaced into the one
compartment in which the materials are to be mixed. In addition,
difficulties are often experienced in loading the device with the
plug in sealing relationship between the compartments and in
displacement of the plug to provide communication between
compartments.
It is an object of this invention to provide a simple and efficient
package in which the materials subsequently to be mixed, at least
one of which is a liquid, can be preloaded into separate members
which are adapted to be joined in sealing relation whereby the two
materials can be safely maintained in their separated relation,
completely sealed one from the other, wherein the liquid component
in one compartment can be displaced for admixture with material in
another compartment without displacement of a foreign material into
the mixing compartment, and wherein the materials in the separated
compartments can be introduced in exact measured amounts for
admixture in the desired ratio for immediate use without exposure
to the atmosphere or other containers thereby to provide for an
uncontaminated, measured increment of the solution or mixture.
These and other objects and advantages of this invention will
hereinafter appear and for purposes of illustration, but not of
limitation, an embodiment of the invention is shown in the
accompanying drawings, in which:
FIG. 1 is a schematic sectional elevational view of the package
representative of the practice of this invention in loaded
condition;
FIG. 2 is a sectional elevational view of the package shown in FIG.
1 with the elements in actuated position;
FIG. 3 is a sectional elevational view of the separated vial with
the freshly mixed solution;
FIG. 4 is an enlarged elevational view of the sealing plug; and
FIG. 5 is an enlarged sectional elevational view of a modification
in the sealing plug and means for establishing communication
therethrough.
The invention will be described with reference to a device or
package in which one material is a particulate, powdered, or other
solid material while the other is a liquid in which the solid
material is to be suspended or dissolved. It will be understood
that instead of a solid particulate or powdered material, the one
material can be a liquid, gel or the like for admixture or solution
with the other liquid immediately prior to use.
Referring now to the drawings for a detailed description of the
invention, the numeral 10 indicates an outer vial which may be in
the form of a test tube or other tubular member which is closed at
the bottom 12 and open at the top 14 with the lip 16, about the
top, extending curvilinearly outwardly. The vial can be formed of
metal, plastic or the like material but it is preferred to form the
vial of glass.
A tubular member 20 which is open at both ends 22 and 24 is
dimensioned to have an outer wall to wall dimension which is less
than the inner wall to wall dimension of the vial 10 so as to
enable the forward end portion 26 of the tubular member to be
received in telescoping relation within the open end 14 of the
vial. The tubular member is formed with a passage 28 extending
continuously therethrough between the open ends. The forward end
portion of the tubular member is formed with a neck portion 30 of
smaller cross-section to provide an inner step-shoulder 32 and the
neck portion is fitted about its outer wall with a sealing member
34 of elastomeric material.
The sealing member 34 is in the form of a stopper having an outer
ribbed portion 36 which fits in gripping relation about the neck
and is adapted to have an outer wall to wall dimension slightly
greater than the inner wall to wall dimension of the vial so as to
grip the vial in sealing relation, as a stopper, while enabling
relative axial movement therebetween for insertion of the tubular
member into the end of the vial during assembly and to enable
removal of the tubular member for separation from the vial after
the materials have been admixed and it is desired to pour the
solution or mixture from the vial.
The rubber stopper 34 is preferably though not necessarily formed
with a diaphragm or disc 38 which spans the open end of the tubular
member to seal the passage and, when present, it is provided with
one or more openings 40 in portions offset laterally from the axial
alignment with the passage and in position to abut the flanged
portion of the neck 30 when in normal position to plug the openings
and which are unseated from the abutment when the diaphragm is
flexed in response to internal pressure imposed by the liquid, as
will hereinafter be described.
When dependence is had on a separate sealing member, provided
within the passage of the tubular member, openings through the disc
portion can be axially aligned with the passage.
The primary seal is provided in the passage of the tubular member
in the form of a rubber-like sealing plug 42 having one or more
axially spaced sealing ribs 44 dimensioned to engage the walls of
the passage through the tubular member in sealing engagement. For
this purpose, it is desirable to dimension the sealing ribs
crosswise by an amount slightly greater than the inner wall to wall
dimension of the tubular member so that the ribbed portions 44 will
be flexed in response to compression during engagement with the
walls so as to insure a sealing engagement therewith. The sealing
disc may be of uniform thickness throughout its cross-section or it
can be formed with a rim portion 46 of greater thickness than the
web portion 48 spanning the area between the rim. One or more slits
50 are provided to extend through the central portion whereby the
slits are closed under normal conditions but are opened in response
to fluid pressure to enable fluid to pass therethrough.
In the preferred embodiment, the sealing plug is in the form of an
integrally formed disc member having axially spaced parallel
circumferential ribs extending radially outwardly from an annular
rim portion with the flexible web having a central slit 50 spanning
the area between the rim.
Instead of forming the sealing member with a central web portion
having a slit, the sealing member can be formed, as shown in FIG.
5, with a web portion 52 which is free of any openings but which is
in position to be pierced by a bayonet 54 fixed to the neck portion
of the tubular member with the piercing point 56 in axial alignment
with the central portion of the web 52 but spaced a short distance
forwardly therefrom in position to pierce the web either upon
flexure of the web in response to internal fluid pressure or in
response to axial displacement of the sealing plug to bring the web
into engagement with the bayonet, in response to fluid
pressure.
A piston plug 60 of resilient material stoppers the rearward end
portion of the tubular member and it is provided with means on the
end thereof for operative engagement by an actuator 62 to effect
displacement of the piston plug through the passage of the tubular
member to force liquid 64 from the tubular member into the vial.
The piston plug 60 is formed of a resilient material and is
dimensioned to be received in the passage of the tubular member in
sealing engagement for axial sliding movement. The outer end
portion of the piston plug can be provided with an attached
actuator rod 62 dimensioned to have a length greater than the
distance that the plug is adapted to be displaced into the tubular
member for forcing the liquid therefrom. Instead, the piston plug
can be provided with a threaded stud or with a threaded recessed
portion 66 into which the threaded forward end 68 of an actuator
can be screwed.
The rearward end of the tubular member is formed with a radially
outwardly extending flanged rim 70 which functions as a finger
grip. Instead, a flanged bracket, which receives the tubular member
in fitting relationship, can be employed as a finger grip.
The liquid component is adapted to be loaded into the tubular
member 20 and it may be preloaded therein in the desired amount for
confinement therein by the piston plug 60 and the sealing plug
42.
The particulate material can be preloaded in the desired amount in
the vial and sealed therein with a conventional stopper or by
assembly of the preloaded tubular member onto the end of the
vial.
After the vial 10 has been loaded with the measured increment of
material to be dissolved or suspended in the liquid, the preloaded
tubular member can be inserted as a stopper for the vial to effect
the assembled package.
It will be apparent that the vial and tubular members are capable
of separate loading for mass production and subsequent assembly to
provide the desired amount of liquid and material to be dissolved
or suspended therein. The assembled unit can be shipped or stored
over extended periods of time without fear of contamination or
premixing of the one material with the other.
When it is desired to combine the two materials, it is only
necessary to effect displacement of the piston plug, as by means of
the actuator 62, while holding the assembly with one hand with two
fingers about the flanged rim portion 70 and the thumb on the
actuator.
In response to displacement of the piston plug, the sealing disc 38
and/or the sealing plug 42 are flexed axially forwardly to free the
passage through which the liquid can flow under pressure from the
tubular member into the vial. When the measured amount of liquid
has been transferred from the tubular member to the vial, the
assembly can be shaken while the vial is still stoppered to admix
the materials for solution or suspension. Thereafter, the tubular
member is removed to free the open end 14 of the vial for pouring
the freshly formed mixture or solution therefrom.
It will be apparent that the package described is subject to a
number of variations and modifications without departing from the
spirit of the invention, especially as defined in the following
claims.
* * * * *