U.S. patent number 3,779,235 [Application Number 05/154,561] was granted by the patent office on 1973-12-18 for cardiovascular test station pressurometer interface system.
This patent grant is currently assigned to Searle Medidata Inc.. Invention is credited to Joseph B. Ferguson, William J. Murphy, Jr., Edward B. Rawson.
United States Patent |
3,779,235 |
Murphy, Jr. , et
al. |
December 18, 1973 |
**Please see images for:
( Certificate of Correction ) ** |
CARDIOVASCULAR TEST STATION PRESSUROMETER INTERFACE SYSTEM
Abstract
A pressurometer interface circuit operative to provide serial,
binary data representative of patient pulse rate and patient
systolic and diastolic blood pressures. In response to automatic
inflation and deflation of a cuff the interface circuit receives in
parallel a plurality of bilevel signals, each associated with a
given cuff pressure and indicating whether a Korotkoff sound
response is detected at the cuff pressure. The bilevel signals are
converted, for efficient data communication, to serial binary coded
data representative of the boundaries of the range of pressures
during which Korotkoff sounds are exhibited. Further binary data is
generated indicating patient pulse rate as interpreted from the
Korotkoff sounds during deflation.
Inventors: |
Murphy, Jr.; William J.
(Framingham, MA), Ferguson; Joseph B. (Harvard, MA),
Rawson; Edward B. (Lincoln, MA) |
Assignee: |
Searle Medidata Inc. (Waltham,
MA)
|
Family
ID: |
22551817 |
Appl.
No.: |
05/154,561 |
Filed: |
June 18, 1971 |
Current U.S.
Class: |
600/495 |
Current CPC
Class: |
A61B
5/02208 (20130101) |
Current International
Class: |
A61B
5/022 (20060101); A61b 005/02 () |
Field of
Search: |
;128/2.5A,2.5D,2.5G,2.5M,2.5N,2.5P,2.5Q,2.5R,2.5T,2.1A,2.6G |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Kamm; William E.
Claims
What is claimed is:
1. A pressurometer interface circuit operative to provide patient
diastolic and systolic pressure data from a pressurometer of the
type having a cyclically inflatable cuff and a plurality of bilevel
signals, each associated with a particular cuff pressure, and being
in one of the two levels in response to the presence of Korotkoff
sounds at the corresponding cuff pressure and in the second of the
two levels in response to the absence of Korotkoff sounds at the
corresponding pressure, said interface circuit comprising:
means for receiving said plurality of bilevel signals;
means for sequentially sampling the level of each of said received
bilevel signals to provide a sequence of sampled signals each
representing a corresponding bilevel signal;
said sampling means including means for providing an indication of
which of said bilevel signals is sampled;
means for detecting a difference in signal level of adjacent
signals in said sequence of sampled signals; and
means responsive to detection of a difference in signal level for
generating an address signal in serial bit form to represent the
sampled, adjacent bilevel signals detected as different, thereby to
provide output indicia of said patient diastolic and systolic
pressure data.
2. The pressurometer interface circuit of claim 1 further
comprising:
means for adjusting the signal level of said received plurality of
bilevel signals to a predetermined range of levels compatible with
said interface circuit.
3. The pressurometer interface circuit of claim 1 further
including:
means responsive to deflation of the pressurometer cuff for
generating pulses coincident with patient Korotkoff sounds; and
means responsive to cuff exhaustion for inhibiting the generation
of said pulses and for enabling sampling by said sampling means of
said plurality of bilevel signals.
4. In combination with a pressurometer interface circuit of the
type claimed in claim 1 further apparatus including:
means for transmitting said generated serial bit form address
signal;
a test station console for receiving said address signal; and
a central computation facility in communication with said console
for data processing of said address signal as received by said
console to provide diastolic and systolic pressure data;
said console, in association with said central computation
facility, having means responsive to said diastolic and systolic
pressure data from said central computation facility for displaying
said data at said console;
said console further having means for causing said central
computation facility to record said diastolic and said systolic
pressure data in response to activation thereof.
5. The apparatus and pressurometer interface circuit of claim 4
further including means for causing recycling of said interface and
pressurometer for additional testing in response to activation
thereof.
6. The pressurometer interface circuit of claim 1 wherein said
sampling means further includes:
a multiplexer system receiving said plurality of adjusted, bilevel
signals at parallel inputs thereof; and
a counter operating at a predetermined frequency to count through a
predetermined number of steps;
said multiplexer system operating in response to the counting of
said counter to provide at an output of said multiplexer system
said sequence of sampled signals;
each step in the count of said counter causing said multiplexer to
provide at the output thereof one signal of said sequence of
sampled signals in correspondence with that step in the count.
7. The pressurometer interface circuit of claim 1 wherein said
address signal generating means includes means for providing an
indication in said address signal of the level of one said
adjacent, different bilevel signals.
8. The pressurometer interface circuit of claim 1 wherein said
sampling means includes means for providing a signal of a
predetermined level in said sequence to indicate the end of said
sequence.
9. An interface circuit operative in association with a blood
pressurometer of the type having a blood flow restricting
inflatable cuff cyclable through an inflate and deflate sequence
and adapted to sense the Korotkoff sounds during at least a portion
of the sequence, said pressurometer further including a plurality
of two display state elements each associated with a particular
pressure in a range of pressures for said cuff, said pressurometer
adapted to cause each of said two state elements to change from a
first display state to a second display state in response to the
existence of said Korotkoff sounds at the corresponding pressure
level of each said element during deflation of said cuff, said
interface circuit comprising:
means for sensing the state of each of said plurality of two state
elements;
means for developing a plurality of bilevel signals, each
representative of the sensed state of a corresponding two state
element;
means for adjusting each said bilevel signal in signal level to a
predetermined data logic scheme;
multiplexer means for receiving each of said plurality of bilevel
signals on one of a plurality of parallel inputs;
a binary counter operative to count at a predetermined rate through
a predetermined number of binary steps;
said multiplexer means being operative in response to the count of
said counter to provide as an output signal, a signal
representative of the level of an input to said receiving means
corresponding to the count of said counter in order to provide at
the output of said multiplexer means a sequence of signals
representative of the signal level at each of said plurality of
parallel inputs to said multiplexer means;
means for sampling and retaining for approximately one step of said
counter each signal in said sequence of signals at the output of
said multiplexer means;
means for comparing each signal in the sequence of signals from
said multiplexer means with the signal retained by said sampling
and retaining means;
said comparing means providing an indication of a difference
between adjacent signals at the output of said multiplexer means;
and
means for generating a signal representative of the count of said
binary counter coincidental with the indication by said comparing
means of different adjacent signals in said sequence.
10. The interface circuit of claim 9 further including:
means for sensing Korotkoff sound signals from said
pressurometer;
means for producing a signal representative of said sensed
Korotkoff sound signals;
means for sensing the state of inflation of said cuff by said
pressurometer;
means for enabling the production of said signals representative of
Korotkoff sound signals only during relatively noise free portions
of an inflate-deflate cycle; and
means for inhibiting said counter whenever said sensed cuff status
indicates partial or complete cuff inflation;
said counter being operative in response to said sensed cuff status
to commence counting at a predetermined count whenever said cuff
status signal indicates cuff exhaustion after an inflate-deflate
cycle.
11. The interface circuit of claim 10 further including:
means for indicating the inflation status of said cuff;
means responsive to the indicated deflation of said cuff and the
sensed Korotkoff sounds for producing patient pulse signals in
serial bit form; and
means for alternatively transmitting said generated and said
produced signals.
12. The interface circuit of claim 9 wherein said generating means
further includes:
second multiplexer means for receiving the binary states of said
counter;
a second counter counting at a predetermined higher rate than the
first mentioned counter;
said second multiplexer means including means responsive to the
count sequence of said second counter for providing as an output a
sequence of signals representative of the binary states of said
first counter as applied to said second multiplexer means.
13. The interface circuit of claim 9 further including means for
causing said generating means to generate an end of sequence signal
when said binary counter has counted through said predetermined
number of binary steps.
14. The interface circuit of claim 9 having apparatus associated
therewith including:
a serial bit data link
means for applying said generated signal to said data link;
control means for recovering said generated signal from said data
link and for applying a supervisory signal to said data link;
said interface circuit including means for recovering said
supervisory signal from said data link and for applying said
recovered supervisory signal to control said binary counter;
said control means having means for determining and displaying
patient cardiovascular data in response to said recovered generated
signal and further including means having first and second states
to record said data in said first state and to enable, with said
supervisory signal, said interface circuit to generate further
signals in said second state.
15. The interface circuit and apparatus of claim 14 further
including:
a tonometer test unit; and
an electrocardiograph test unit;
means for interconnecting said units with said control means for
processing received test information.
Description
FIELD OF THE INVENTION
This invention relates to electronically automated medical
examination of patients and in particular to data interfacing for
pressurometer testing.
BACKGROUND OF THE INVENTION
Modern medical examination procedures are placing increasing
reliance upon electronics for gathering the response of patients to
a variety of new and traditional patient tests. One of the
traditional tests being performed electronically today is the
reading of patient pulse rate and blood pressure. Several units are
commercially available, such as the Avionics Research Products,
Pressurometer Model 1900, which provide a visual display of the
correlation between patient blood pressure and the existence of
patient Korotkoff sounds. Korotkoff sounds are noise generated by
blood flowing through vessels which are partially constricted in
response to the degree of inflation of an inflatable cuff wrapped
around a patient's extremity. Patient systolic and diastolic
pressure levels, the medically significant parameters of a
patient's blood pressure, are indicated by the largest and smallest
pressures for which Korotkoff sounds are detected by the
pressurometer.
While such a pressurometer greatly simplifies the task of obtaining
patient blood pressure data, manual reading of the pressurometer
scales and manual recording of pressure data is still required.
This additional work reduces the efficiency of blood pressure
testing and increases its cost as well as the chance of error. A
need clearly exists for an electronic system capable of directly
converting pressurometer output format into machine readable binary
signals representative of patient diastolic and systolic pressure.
At the same time, significant efficiency in medical data taking can
be gained if patient pulse rate can be determined during the blood
pressure test to avoid the necessity of connecting additional
apparatus to the patient to sample this pulse rate. Finally, since
pressurometer data may have to be transmitted over a distance
through a data link, data should be presented to the data link in a
form allowing for efficient communication.
SUMMARY OF THE INVENTION
An interface circuit is provided operative with available
pressurometer units of the type which correlate patient blood
pressure with the presence of Korotkoff sounds, the interface
circuit providing, in serial bit form, binary coded signals
representing patient diastolic and systolic blood pressures and
patient pulse rate for subsequent machine data processing.
In pressurometers of the type indicated, a plurality of selectively
illuminated lamps are provided with each lamp corresponding to a
particular patient blood pressure level. The pressurometer is
operative to cycle an inflatable cuff through an inflation and
deflation sequence and during deflation the selectively illuminated
lamps are lighted in response to detection of Korotkoff sounds at
the patient pressure level corresponding to each lamp.
Also during cuff deflation detected Korotkoff sounds are pulse
shaped and encoded into a uniquely recognizable serial, binary
sequence and conveyed to a station console and associated central
processor in real time sequence to indicate patient pulse rate.
After complete deflation and evacuation of the cuff, the interface
circuit switches to a blood pressure mode in which the status of
the pressurometer lamps are sequentially sampled to enable the
generation of binary coded signals representing diastolic and
systolic pressure levels. The interface circuit performs this
function by sequentially sampling the status of each lamp and
detecting the existence of a different lamp status between adjacent
pressure levels, indicative of a transition between Korotkoff
sounds and no Korotkoff sounds at the corresponding pressure level.
Upon the detection of a lamp status transition, the identity of a
lamp adjacent the transition is automatically read out in serial
binary form and conveyed to the central processing unit via the
test station console.
DESCRIPTION OF THE DRAWINGS
These and other features of the invention will be more fully
understood by reference to the following detailed description of a
preferred embodiment, presented for purposes of illustration and
not by way of limitation and to the accompanying drawings of
which:
FIG. 1 is a pictorial view of a pressurometer interface circuit in
a cardiovascular test station; and
FIG. 2 is a partial schematic and partial block diagram of an
interface circuit according to the invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
In the realm of medical science the taking of patient blood
pressure information is achieved by strapping an inflatable cuff
around a patient's arm, or other extremity, and inflating the cuff
to the point where the circulation of arterial blood flow in
vessels is inhibited. Cuff pressure is then reduced at a slow,
controlled rate until the attending physician detects, through the
use of a stethoscope, the presence of Korotkoff sounds indicating
the beginning of blood flow through the constricted blood vessels.
The pressure at which Korotkoff sounds are first noticed is known
as the systolic blood pressure level. With further cuff deflation,
a pressure is reached where Korotkoff sounds are last noticed, and
this pressure is termed the diastolic pressure level.
Referring now to FIG. 1, there is shown a cardiovascular test
station set up for measuring patient blood pressure and pulse rate
and utilizing a pressurometer interface circuit 12 according to the
invention. In the example of FIG. 1, a patient 14 has an inflatable
cuff 16 wrapped around his arm and connected to a pressurometer 18
of the type exemplified by Avionics Research Products,
Pressurometer Model 1900. A pressure pump and a release valve, not
shown, within the pressurometer 18, are connected through pneumatic
tubing 20 to the cuff 16. Within the cuff 16 a detector 22 senses
blood vessel Korotkoff sounds and conducts electrical
representations thereof over a line 24 to the pressurometer 18.
In operation, the pressurometer 18 is automatically, or manually,
cycled to provide inflation pressure to the cuff 16, pressurizing
it to a point where all blood flow through the vessels of the arm
is eliminated. The pressurometer 18 then deflates the cuff 16 at a
predetermined rate until the cuff is exhausted.
During deflation of the cuff 16, detection circuitry within the
pressurometer 18 samples the signal on line 24 for the existence of
Korotkoff sounds at predetermined pressure levels, and if a
Korotkoff sound is detected at that pressure level a corresponding
lamp, of a set of lamps 26 on the face of the pressurometer 18, is
illuminated. After an inflation and deflation cycle has been
completed by the pressurometer 18, a series of lamps in the set 26
will be illuminated denoting the range of patient blood pressures
during which Korotkoff sounds were detected.
By appropriate connection within the pressurometer 18, a plurality
of electrical lines 28 are provided from the pressurometer 18 to
the interface circuit 12, with each line carrying a signal
representative of the status of a corresponding lamp in the set 26.
Additionally, a signal representative of the detected Korotkoff
sounds is conducted from the pressurometer 18 over a line 30 to the
interface circuit 12, a signal indicating that the cuff is
deflating is fed to the interface over line 31, and a signal
indicating cuff exhaustion is provided from the pressurometer 18
over a line 32 to the interface circuit 12.
The pressurometer interface circuit 12 converts the plurality of
inputs containing pulse rate and pressure information into serial
data and conveys it, via a single line 34, through a data link 35,
to a cardiovascular station console 36. The data link 35 may
include substantial distance and it is, therefore, an economic
benefit that data is in serial bit form and only necessitates a
single data line 34. Supervisory and clock signals are provided by
preferably a single line 38 from the console 36 to the interface
circuit 12.
Referring to FIG. 2, and the more detailed description of the
interface circuit 21, the plurality of lamp condition lines 28 are
conducted to an attenuator and inverter circuit 40 which provides
signal level normalization of the lamp status signals through a
plurality of corresponding voltage dividers 42 and transistor
driving circuits 44 in order to match level requirements for the
interface circuit 12. The plurality of normalized lamp condition
signals are bunched in groups of, for example, six signals, each
group leading into one of a plurality of primary multiplexer
circuits 46 through 56. An output from each primary multiplexer
46-56 is conducted to a secondary multiplexer circuit 58 along with
an end of test signal. The output of the secondary multiplexer 58
is conducted to a sample and temporary hold circuit 60 and to one
input of an exclusive OR gate 62. The output of the sample and hold
circuit 60 is conducted to a second input of the exclusive OR gate
62. The output of the exclusive OR gate 62 is conducted to a
junction circuit 64 which in turn passes the signal of gate 62 to a
gate 66 that feeds the data line 34 to the test station console 36
via data link 35.
The supervisory signal on line 38 from the console 36 comprises a
clock signal conducted, through an amplifier 67, to a binary
counter 68 that counts through a plurality of steps in a
predetermined count including one step for each of the lamps in the
pressurometer 18 and at least one additional step for control
purposes. A further counter 70 receives the clock signal on line 38
and provides a binary count through a predetermined number of steps
for each step of the counter 68. The binary states of the counter
70 are fed in parallel to an address multiplexer 72 along with the
binary states, in parallel, from the counter 68. The binary states
of the counter 68 are also applied to the primary multiplexers 46
through 56 and to the secondary multiplexer 58. The counter 68 has
a reset and enable signal provided to it over line 32.
When appropriately reset and enabled, the counter 68 operates to
count through the steps of its predetermined count in response to
the clock signal on line 38. Each of the primary multiplexers 46
through 56 is adapted to recognize a predetermined binary state in
the count of counter 68 in an exclusive range for each primary
multiplexer and to provide an output signal representative of the
one of its inputs which corresponds to the particular binary state
of the counter 68. The secondary multiplexer 58 is adapted to
recognize the exclusive ranges of binary states from the counter 68
and provide at its output a signal representative of the signal
input thereto from the particular one of the primary multiplexers
in the corresponding exclusive range of binary states recognized.
In this fashion the primary multiplexers 46 through 56 and the
secondary multiplexers 58 operate as a single pole multiple throw
switch cycling in correspondence with the states of the counter 68
to sample each of the plurality of inputs to the primary
multiplexers and to provide at an output of the secondary
multiplexer a signal representing the status of the input
sampled.
The output of the multiplexer 58 is sampled by the sample and hold
circuit 60 and held for the duration of one step in the counter 68
such that its output is representative of the condition of the lamp
previously sampled. The exclusive OR gate 62 receives as inputs the
current and previously sampled lamp conditions and provides an
output indicating when its two inputs differ. The two inputs differ
in response to a transition between lighted and unlighted lamps and
correspondingly a transition between the existence of Korotkoff
sounds and non-existence of Korotkoff sounds.
The output of the exclusive OR gate 62, indicating this transition,
is conducted through the junction circuit 64 to the gate 66 where
it causes the gate 66 to respond to and pass the signal from the
address multiplexer 72. The address multiplexer 72 operates to
provide, as its output to the gate 66, a sequence of binary signals
representative of the state of the counter 68 at the time of
detected transition. The counter 70 effects the sampling of the
state of the counter 68 by causing the multiplexer 72 to sample
each of the binary states of counter 68 in correspondence with the
count of the counter 70. The output of the multiplexer 72, in
response to a transition, comprises an initial bit of predetermined
information followed by binary signals indicating the state of
binary counter 68. The output of the sample and hold circuit 60 is
also applied to the multiplexer 72 which encodes that signal in the
last bit of data provided from the multiplexer.
The end of test signal applied to secondary multiplexer 58 causes
detection of an artificial transition beyond the pressure range of
the pressurometer and thus produces a signal which is communicated
to the console 36 to indicate the completion of a test. The console
36 operating with a central processing unit or computer 74
recognizes the end of test address and operates to preclude further
testing for that patient unless an override is activated. The
interface can be signaled to stop testing, by, for example,
removing the clock signal.
The Korotkoff sounds and the cuff deflation and exhaustion status
signals from the pressurometer 18 are applied respectively over
lines 30, 31 and 32 to the circuits of FIG. 2. The Korotkoff sounds
on line 31 are applied to a gate 82. The cuff deflation signal on
line 31 is applied to a detector 84 which provides an enable signal
to gate 82 when the cuff is in the deflation portion of an
inflation-deflation cycle. The Korotkoff sounds are conducted from
gate 82 during deflation only, to eliminate noise interference from
rapid inflation, and applied to a pulse shaper circuit 86 which
also receives the clock signal and produces an output pulse of
appropriate shape to reflect patient pulse which it represents
synchronized with the clock signal on line 38. This signal is
conducted to junction circuit 64 and thence to gate 66. The signal
from multiplexer 72 to gate 66 is normally at an enable level and
thus permits passage of the clocked pulse signals through gate 66
to console 36 to indicate patient pulse.
The cuff exhaustion signal on line 32 is fed to counters 68 and 70
and resets the counters 68 and 70. Prior to exhaustion, this signal
by application to counters 68 and 70 prevents counter operation and
thus inhibits system operation but after cuff exhaustion by
resetting counters 68 and 70 enables the system operation described
above and thereby causes the lamps of the pressurometer 18 to be
sampled and read out through gate 66.
As shown in FIG. 1 and FIG. 2 the console 36 is a central control
system for a cardiovascular station which includes a manual or
automatic tonometer 90 and a manual or automatic electrocardiograph
92 communicating with the console 36 to provide patient data in
response to control signals. All tests are conveniently performed
with the patient in a horizontal position. As shown in FIG. 2 the
central processing unit 74 is operative in conjunction with the
console 36 to receive patient data and perform appropriate
calculations thereon to provide indicia of patient cardiovascular
condition. In response to data on patient blood pressure and pulse
rate, the console 36 communicates this data to the central
processing unit 74 which, after calculation of blood systolic and
diastolic pressures and pulse rate, returns this information to the
console for presentation on a display 96. An enter button 98 is
provided on the console 36 to cause the central processing unit 74
to record the displayed data as part of the patient's medical
information in response to activation of the entry button 98 when
the test operator is satisfied with the appearance of the data. A
repeat button 100 is provided to enable recycling of the test if
the data is unsatisfactory. When the button 100 is depressed, the
clock signal is reapplied and the test is recycled in response to
activation of a cycle button on the pressurometer.
Having described a preferred embodiment of the present invention,
it will occur to those skilled in the art that modifications and
alterations can be made to the specific disclosure while
accomplishing the spirit of the invention. It is accordingly
intended to limit the scope of the invention only as indicated in
the following claims.
* * * * *