U.S. patent number 3,768,486 [Application Number 05/233,135] was granted by the patent office on 1973-10-30 for atrial and ventricular demand pacer having wide-range atrial escape interval.
This patent grant is currently assigned to American Optical Corporation. Invention is credited to Barouh V. Berkovits, Robert A. Guillette.
United States Patent |
3,768,486 |
Berkovits , et al. |
October 30, 1973 |
ATRIAL AND VENTRICULAR DEMAND PACER HAVING WIDE-RANGE ATRIAL ESCAPE
INTERVAL
Abstract
There is disclosed an atrial and ventricular demand pacer in
which the atrial escape interval can be set to be less than 50
percent of the ventricular escape interval without multiple
stimulations of the atria between ventricular beats. The atrial
pulse generating circuit is triggered upon the occurrence of each
ventricular beat, a single atrial stimulating pulse then being
generated unless another ventricular beat is first detected within
the atrial escape interval. Because an atrial stimulating pulse
requires a trigger (ventricular beat), only one atrial stimulating
pulse can be generated after each ventricular beat.
Inventors: |
Berkovits; Barouh V. (Newton
Highlands, MA), Guillette; Robert A. (Methuen, MA) |
Assignee: |
American Optical Corporation
(Southbridge, MA)
|
Family
ID: |
22876015 |
Appl.
No.: |
05/233,135 |
Filed: |
March 9, 1972 |
Current U.S.
Class: |
607/27 |
Current CPC
Class: |
A61N
1/368 (20130101) |
Current International
Class: |
A61N
1/368 (20060101); A61n 001/36 () |
Field of
Search: |
;128/419P,421,422 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Kamm; William E.
Claims
What I claim is:
1. An atrial and ventricular pacer comprising ventricular pulse
generating means for generating a ventricular stimulating pulse for
extension to a patient's heart following the expiration of a
ventricular escape timing interval, means for detecting a
spontaneous ventricular beat of a patient's heart or the generation
of a ventricular stimulating pulse for synchronizing said
ventricular pulse generating means to the beating action of the
patient's heart, timing means responsive to the operation of said
detecting means for measuring an atrial escape timing interval,
means for adjusting the width of said atrial escape timing
interval, means responsive to the expiration of said atrial escape
timing interval for generating one and only one atrial stimulating
pulse for extension to a patient's heart for each single operation
of said detecting means and independent of the duration of said
atrial escape timing interval, said timing means including a
capacitor, first means for discharging said capacitor responsive to
the operation of said detecting means, means for controlling the
charging of said capacitor following the discharge thereof, second
means conductively connected to said first discharging means and
responsive to the voltage across said capacitor reaching a firing
level for discharging said capacitor and controlling the operation
of said atrial stimulating pulse generating means, and means for
maintaining said second discharging means conducting to hold the
voltage across said capacitor below said firing level, said second
discharging means turning off only after said capacitor is
discharged by said first discharging means.
2. An atrial and ventricular pacer in accordance with claim 1
wherein said ventricular pulse generating means includes means for
adjusting the width of the respective escape timing interval, and
each of said pulse generating means includes means for adjusting
the width of the respective generated stimulating pulse.
3. An atrial and ventricular pacer comprising ventricular pulse
generating means for generating ventricular stimulating pulses for
extension to a patient's heart, means for synchronizing said
ventricular pulse generating means to the beating action of a
patient's heart, timing means for operating in synchronism with the
beating action of a patient's heart for measuring an atrial escape
timing interval, means for adjusting the width of said atrial
escape timing interval, means responsive to the expiration of said
atrial escape timing interval for generating at most one atrial
stimulating pulse for extension to a patient's heart for each
venticular beating action of the patient's heart independent of the
duration of said atrial escape timing interval, said timing means
including a capacitor, first means for discharging said capacitor
responsive to a beating action of a patient's heart, means for
controlling the charging of said capacitor following the discharge
thereof, second means conductively connected to said discharging
means responsive to the voltage across said capacitor reaching a
firing level for discharging said capacitor and controlling the
operation of said atrial stimulating pulse generating means, and
means for maintaining said second discharging means conducting to
hold the voltage across said capacitor below said firing level,
said second discharging means turning off only after said capacitor
is discharging by said first discharging means.
4. An atrial and ventricular pacer in accordance with claim 3
wherein said atrial pulse generating means includes means for
adjusting the width of the generated atrial stimulating pulse
following the expiration of said atrial escape timing interval.
5. An atrial and ventricular pacer in accordance with claim 3
wherein said width adjusting means of said atrial escape timing
interval is adjustable to produce an escape interval less than 50
percent of the time interval separating successive stimulating
pulses generated by said ventricular pulse generating means.
Description
This invention relates to atrial and ventricular demand pacers, and
more particularly to such pacers in which at most one atrial
stimulating pulse is generated for each ventricular beat.
In my co-pending application Ser. No. 214,218 filed on Dec. 30,
1971, which application is hereby incorporated by reference, there
is disclosed an improved synchronized atrial and ventricular pacer.
Each of the atrial and ventricular pulse generating circuits
functions to generate a stimulating pulse a respective
predetermined time interval after the last ventricular beat. The
ventricular escape interval (the time period between successive
ventricular beats) is longer than the atrial escape interval (the
time period between successive ventricular and atrial beats) so
that an atrial stimulating pulse, if one is required, will be
generated before a ventricular stimulating pulse, if one is
required, Each detected ventricular beat controls the resetting of
both pulse generating circuits. In the presence of 60-Hz noise,
both pulse generating circuits operate in a continuous mode, as
opposed to a demand mode. In such a case, whenever a ventricular
stimulating pulse is generated not only does the ventricular pulse
timing circuit restart, but so does the atrial pulse timing
circuit. Thus, even in the presence of noise the atrial pulse
generating circuit is synchronized to the ventricular pulse
generating circuit.
In the pacer disclosed in the aforesaid application, as well as in
other prior art atrial and ventricular pacers, each of the pulse
generating circuits is free-running in that respective atrial or
ventricular stimulating pulses are generated at fixed intervals in
the absence of the resetting of the pulse generating circuit. The
pacer timing is synchronized to the natural heartbeats by
controlling the resetting of the two circuits upon the detection of
each ventricular beat. While systems of this type are satisfactory
for implantable pacers, a problem has been encountered when they
are used in connection with external pacers, that is, pacers which
are external to the patient except for electrical leads.
In an atrial and ventricular demand pacer, each of the pulse
generating circuits includes a potentiometer which can be adjusted
for setting the respective escape interval. Since the pulse
generating circuits are free-running in the absence of a resetting
pulse, it is apparent that if the atrial escape interval is less
than 50 percent of the ventricular escape interval, then two or
more atrial stimulating pulses may be generated between each pair
of ventricular stimulating pulses. The detection of a ventricular
beat, or the generation of a ventricular stimulating pulse, causes
both pulse generating circuits to be reset. If the ventricular
escape interval is N milliseconds and the atrial escape interval is
less than N/2 milliseconds, since both pulse generating circuits
are free-running, it is apparent that if a spontaneous ventricular
beat is not detected prior to the expiration of the ventricular
escape interval, then at least two atrial stimulating pulses will
be generated. That is because atrial stimulating pulses are
generated continuously and at fixed time intervals in the absence
of the detection of a spontaneous ventricular beat or the
generation of a ventricular stimulating pulse. Multiple atrial
stimulating pulses, of course, can only produce deleterious effects
since the atria should not be stimulated too close in time to the
ventricular beat.
In the case of implantable pacers, where the potentiometer settings
are established on the production line and are not subject to
change, the problem is not severe because satisfactory production
procedures can be employed for ensuring that multiple stimulating
pulses are not generated. However, in the case of an external
pacer, medical and hospital personnel adjust the various control
knobs to vary the two escape intervals. Especially with poorly
trained personnel, the atrial escape interval can be set to be less
than 50 percent of the ventricular escape interval, in which case
multiple atrial stimulation is possible.
It is a general object of my invention to provide an atrial and
ventricular pacer in which multiple atrial stimulation is precluded
even with very short atrial escape intervals.
In accordance with the principles of my invention, the ventricular
pulse generator is free-running as in prior art pacers. However,
the atrial pulse generating circuit is not; instead, it includes a
one-shot multivibrator. The detection of a spontaneous ventricular
beat, or the generation of a ventricular stimulating pulse,
triggers an atrial timing circuit. At the end of the pre-set atrial
escape interval, the multivibrator is fired and an atrial
stimulating pulse is generated. Thereafter, the multivibrator
returns to the quiescent state; no further atrial stimulating
pulses are generated. In order for the multivibrator to be
triggered once again, a new timing period must be initiated, and
this takes place only when the next spontaneous ventricular beat is
detected or the next ventricular stimulating pulse is generated.
Even if the atrial escape interval is set to be less than 50
percent of the ventricular escape interval, the multivibrator is
triggered only once for each ventricular beat. Consequently, it is
not possible for there to be multiple atrial stimulations between
ventricular beats.
It is a feature of my invention to provide in the atrial pulse
generating circuit a mechanism for generating only a single atrial
stimulating pulse after a predetermined time interval has elapsed
following the detection of the last spontaneous beat or the
generation of the last ventricular stimulating pulse.
Further objects, features and advantages of my invention will
become apparent upon consideration of the following detailed
description in conjunction with the drawing in which:
FIG. 1 is the same as the drawing in my above-identified
application and discloses the circuitry of an atrial and
ventricular pacer which can result in multiple atrial stimulations
if care is not taken in insuring that the atrial escape interval is
greater than 50% of the ventricular escape interval; and
FIG. 2 depicts an illustrative embodiment of the present
invention.
Only those parts of the circuit of FIG. 1 will be explained which
are required for an understanding of the present invention. The
pacer includes a pair of electrodes, E1 and E2, which are used for
ventricular stimulation and a pair of electrodes, E3 and E4, which
are used for atrial stimulation. A spontaneous ventricular beat
causes a signal to appear on electrodes E1 and E2, and this signal
is processed and results in a pulse being applied through capacitor
53 to the base of transistor T6 and through capacitor 54 to the
base of transistor T10. (If switch S is closed, then the pacer
operates in a continuous mode and no pulses are extended to the
bases of transistors T6 and T10. Similarly, in the presence of
60-Hz noise, transistors T3 and T4 function to prevent the
application of pulses to the bases of transistors T6 and T10 so
that the pacer can operate in the continuous mode.) Capacitor 57
normally charges from batteries 1-5 through potentiometer 35,
poteniometer 37, and resistors 61 and 63. When the voltage across
the capacitor is sufficient to fire transistors T7 and T8, these
transistors conduct and a large current flows through them to raise
the potential across resistor 63. At this time transistor T9 fires
and capacitor 65 discharges through the transistor, the electrodes
and the heart tissue to stimulate the ventricles. After transistor
T9 turns off, capacitor 65 recharges in preparation for the
generation of another stimulating pulse. The setting of
potentiometer 35 determines the magnitude of the charging current
for capacitor 57. This, in turn, determines the ventricular escape
interval. Each time that the voltage across capacitor 57 is high
enough to cause transistors T7 and T8 to fire, the capacitor
discharges through them so that another timing cycle can begin. The
duration of the discharge is determined by the setting of
potentiometer 37. Since a large current flows through resistor 63
whenever transistors T7 and T8 conduct, it is apparent that the
setting of potentiometer 37 determines the width of the ventricular
stimulating pulse. If a spontaneous ventricular beat is detected
before the expiration of the ventricular escape interval, then
transistor T6 conducts and capacitor 57 discharges through it. In
such an event, the ventricular stimulating pulse which would
otherwise have been generated when the voltage across capacitor 57
would have reached the firing level is not generated. Instead, a
new timing cycle begins, with a ventricular stimulating pulse being
generated only if the ventricular escape interval elapses before
the detection of another spontaneous ventricular beat.
The atrial pulse generating circuit is very similar to the
ventricular pulse generating circuit. Capacitor 58 is the timing
capacitor, with potentiometer 62 being used to adjust the atrial
escape interval and potentiometer 60 being used to adjust the
atrial stimulating pulse width. Whenever the voltage across
capacitor 58 reaches the triggering level transistors T11 and T12
conduct, and a large current flows through resistor 66. At this
time transistor T14 conducts and (through a circuit different from
that used in the ventricular pulse generator) an atrial stimulating
pulse flows through electrodes E3 and E4. If a spontaneous
ventricular beat is detected after the previous ventricular beat
and prior to the expiration of the atrial escape interval, then the
pulse transmitted through capacitor 54 to the base of transistor
T10 controls the discharge of capacitor 58. In such a case, an
atrial stimulating pulse is not generated and a new atrial timing
period begins. Since it is possible for a premature ventricular
beat to occur prior to the expiration of the atrial escape
interval, the detection of a spontaneous ventricular beat controls
the resetting of the atrial pulse generator along with the
resetting of the ventricular pulse generator so that the two pulse
generating circuits are synchronized to each other and to the
natural heart rhythm. Furthermore, in the presence of noise when
spontaneous ventricular beats cannot be detected reliably, the
generation of a ventricular stimulating pulse causes the atrial
pulse generating circuit to be reset; when transistors T7 and T8
conduct, a pulse is transmitted through diode 36 and resistor 38 to
the base of transistor T10. Thus, at the same time that capacitor
57 discharges through transistors T7 and T8 to control the
generation of a ventricular stimulating pulse and the start of a
new ventricular escape timing interval, capacitor 58 discharges
through transistor T10 to control the start of a new atrial escape
timing interval. In this manner the two pulse generating circuits
are synchronized to each other even when spontaneous ventricular
beats are not detected (either as a result of noise, or the failure
of the ventricular beat detecing circuit).
The problem with using the circuit of FIG. 1 for an external pacer
in which the settings of potentiometers 35 and 62 can be manually
adjusted by medical or hospital personnel is that it is possible
for the atrial escape interval to be set to be less than 50 percent
of the ventricular escape interval. In such a case, consider what
happens following the detection of a spontaneous ventricular beat
or the generation of a ventricular stimulating pulse. In the former
situation, capacitor 57 discharges through transistor T6 and in the
latter the capacitor discharges through transistors T7 and T8. But
in either case, the ventricular escape timing interval begins at
this time. Also, in both situations the base of transistor T10 is
pulsed (in the former situation, through capacitor 54, and in the
latter situation, through diode 36 and resistor 38) and capacitor
58 discharges through transistor T10. Thus the atrial escape timing
interval also begins at this time. Sometime before half of the
ventricular escape timing interval has elapsed the potential across
capacitor 58 is great enough to fire transistors T11 and T12. At
this time an atrial stimulating pulse is generated and capacitor 58
discharges through the two transistors. The capacitor then starts
to charge once again through potentiometer 62 and after another
atrial escape interval has elapsed, a second atrial stimulating
pulse is generated. Depending of how low the setting of
potentiometer 62, two or more stimulating pulses may be generated
before another spontaneous ventricular beat is detected or another
ventricular stimulating pulse is generated. In either case, the
atrial escape timing interval in progress is interrupted when the
next ventricular beat (either spontaneous or stimulated) occurs so
that the two pulse generators are synchronized to each other. But
it is apparent that multiple atrial stimulating pulses have been
generated to the detriment of the patient.
In accordance with the principles of my invention, the circuit of
FIG. 2 has a considerably different atrial pulse generator.
Capacitor 58 charges through potentiometer 62, the setting of the
potentiometer determining the atrial escape interval. That end of
the capacitor connected to the emitter of transistor T10 is
returned directly to conductor 9, rather than through resistors 64
and 66 as in the circuit of FIG. 1. Potentiometer 60 is not
provided in the circuit of FIG. 2 because it is potentiometer 95
which determines the width of the generated pulse.
In the circuit of FIG. 1, the level to which the voltage across
capacitor 58 must rise before transistors T11 and T12 turn on is
determined by the potential of the base of transistor T11. This
potential, or firing level, is derived by resistors 70, 72 and 74,
transistor T13 and diode 76. Capacitor 68 functions as a filter to
prevent variations in the firing level as various transients are
generated in the overall circuit. In the circuit of FIG. 2,
transistor T13 and diode 76 are not provided, and the firing level
is determined by the relative magnitudes of resistors 70, 72 and
74, the base of transistor T11 being connected to the junction of
resistors 72 and 74. To minimize the effect of transients, filter
capacitor 98 is connected between the junction of resistors 70 and
72, and conductor 9.
when capacitor 58 fires through transistors T11 and T12, an atrial
stimulating pulse is generated. Transistors T11 and T12 do not then
turn off. In the steady state, a small current flows from the
batteries through potentiometer 62, transistors T11 and T12,
resistor 92, potentiometer 95, and resistors 96 and 97. The current
is large enough to keep transistors T11 and T12 on, but it is small
enough so that the potential developed across resistors 97 does not
forward bias the base-emitter junction of transistor T14. The
voltage across capacitor 58 is equal to the battery voltage minus
the drop across potentiometer 62. When transistors T11 and T12
first conduct, as will be described below, current also flows
through capacitor 93 and resistor 94. Capacitor 93 charges and then
discharges until the potential across it is equal to the potential
drop across potentiometer 95, and resistors 96 and 97 connected in
series. At this time a steady-state condition is reached in which
there are no voltage variations in the circuit.
As soon as a spontaneous ventricular beat is detected or a
ventricular stimulating pulse is generated, transistor T10 conducts
and capacitor 58 fully discharges through it. At this time, the
voltage across transistors T11 and T12 is negative (relative to the
direction of current flow through them) since capacitor 93 is
charged slightly. Prior to the discharge of capacitor 58,
transistors T15 and T16 are held off because no current flows
through capacitor 93 and resistor 94 to forward bias the
base-emitter junction of transistor T16; with transistor T16 being
held off, no base current can flow in transistor T15. As soon as
transistors T11 and T12 turn off and no longer deliver current
through potentiometer 95 and resistors 96 an 97, capacitor 93
discharges through these elements and resistor 94. Transistors T15
and T16 still remain off because the direction of current flow
through resistor 94, as a result of the discharge of capacitor 93,
is in a direction to reverse bias the base-emitter junction of
transistor T16. With transistors T10, T11 and T12 off, capacitor 58
begins to charge through potentiometer 62 from a near-zero level as
a result of its heavy discharge through transistor T10. As soon as
the capacitor voltage rises sufficiently to forward bias the
base-emitter junction of transistor T11 (the time interval for this
taking place being determined by the setting of potentiometer 62,
that is, the atrial escape interval), transistors T11 and T12
conduct and current flows through resistor 92, capacitor 93 and the
base-emitter junction of transistor T16. The transistor turns on
and controls the conduction of transistor T15. When the latter
transistor turns on, the additional current through potentiometer
95 contributes to the charging of capacitor 93. Current from
transistor T15 also flows through resistors 96 and 97, and the
resulting pulse across resistor 97 turns on transistor T14 to
control the application of an atrial stimulating pulse to the
atrial electrodes.
As soon as transistors T11 and T12 fire, capacitor 93 starts to
charge from both transistor T12 and transistor T15. Eventually, the
current through resistor 94 is so small that transistors T16 and
T15 turn off. Capacitor 93 then starts to discharge through
potentiometer 95, and resistors 94, 96 an 97. The capacitor stops
discharging when the voltage across it equals the combined drop
across potentiometer 95, and resistors 96 and 97 (produced by
current flow from transistor T12). The combined drop is determined
by the potentiometer and the resistor magnitudes. Capacitor 58 no
longer can fire transistors T11 and T12 because these transistors
are already on. The capacitor voltage remains equal to the battery
voltage drop across potentiometer 62. For another atrial
stimulating pulse to be generated, it is necessary to completely
discharge the capacitor through transistor T10 so that transistors
T11 and T12 can turn off and capacitor 93 can fully discharge.
Thereafter, capacitor 58 starts to charge toward the firing level
and when it reaches the firing level an atrial stimulating pulse is
generated. Thus, only one atrial stimulating pulse can be generated
for each ventricular beat trigger (turning on of transistor
T10).
When transistor T15 first turns on, following the expiration of the
atrial escape timing interval when transistors T11 and T12 turn on,
collector current from transistor T15 flows through resistors 96
and 97 to turn on transistor T14. But collector current also flows
through potentiometer 95 and capacitor 93 to contribute to the
charging of the capacitor. Thus capacitor 93 is charged not only
from the emitter current of transistor T12, but also from the
collector current of transistor T15 flowing through potentiometer
95. Transistor T14 conducts only as long as transistor T15 is on;
thus the atrial stimulating pulse width is determined by the
setting of potentiometer 95 since the potentiometer impedance
determines the time constant of the charging circuit which includes
capacitor 93.
Not only does the circuit of FIG. 2 allow continuous adjustment of
the two escape intervals and the pulse widths but in accordance
with the principles of the invention the atrial escape interval can
be made less than 50 percent of the ventricular escape interval
without producing multiple atrial stimulations.
Although the invention has been described with reference to a
particular embodiment, it is to be understood that this embodiment
is merely illustrative of the application of the principles of the
invention. Numerous modifications may be made therein and other
arrangements may be devised without departing from the spirit and
scope of the invention.
* * * * *