U.S. patent number 3,762,397 [Application Number 05/135,350] was granted by the patent office on 1973-10-02 for method and apparatus for the detection and recordation of high frequency sound in the cardiovascular system.
This patent grant is currently assigned to Hewlett-Packard Company. Invention is credited to John M. Cage.
United States Patent |
3,762,397 |
Cage |
October 2, 1973 |
**Please see images for:
( Certificate of Correction ) ** |
METHOD AND APPARATUS FOR THE DETECTION AND RECORDATION OF HIGH
FREQUENCY SOUND IN THE CARDIOVASCULAR SYSTEM
Abstract
High frequency sound, such as that produced by turbulence, in
the cardiovascular system is sensed, amplified, demodulated, and
filtered to produce an average of the amplitude of the sound, the
demodulated signal being synchronously averaged over a plurality of
successive cycles of the heart to produce a clear signature trace
of the demodulated sound, even in the presence of background
noise.
Inventors: |
Cage; John M. (Los Altos,
CA) |
Assignee: |
Hewlett-Packard Company (Pala
Alto, CA)
|
Family
ID: |
22467704 |
Appl.
No.: |
05/135,350 |
Filed: |
April 19, 1971 |
Current U.S.
Class: |
600/513;
600/528 |
Current CPC
Class: |
A61B
5/02 (20130101) |
Current International
Class: |
A61B
5/02 (20060101); A61b 005/02 () |
Field of
Search: |
;128/2.5R,2.5S,2.6R,21B,2K |
References Cited
[Referenced By]
U.S. Patent Documents
Other References
Moyer et al., "Transactions of the American Institute of Electrical
Engineers", Vol. 80, Part I, 1961, pp. 717-721..
|
Primary Examiner: Kamm; William E.
Claims
I claim:
1. The method of analyzing cardiovascular sound comprising the
steps of:
detecting the sound signals produced repetitively from a source
within the body;
detecting a periodic condition in the body synchronous with said
repetitively produced sound signals;
demodulating said detected sound signals to produce a data signal
representative of the average of the amplitude over a selected past
period of time;
synchronizing the detected sound signals with said periodic
condition in the body synchronous with said detected sound
signals;
averaging a plurality of said demodulated signals over a plurality
of successive time periods to obtain an average of the amplitudes
of the demodulated signals; and
displaying said average of the amplitudes.
2. The method as claimed in claim 1 wherein the step of
synchronizing the detected sound signals with a periodic condition
comprises the steps of synchronizing with an electrocardiographic
signal.
3. The method as claimed in claim 1 wherein the step of detecting
the sound signals comprises selecting a band pass above 200 Hz and
below 20,000 Hz.
4. The method as claimed in claim 1 wherein the step of averaging a
plurality of sound signals comprises averaging over at least
2.sup.6 signals.
5. Apparatus for analyzing cardiovascular sound comprising:
means for detecting the sound signals produced repetitively from a
source within the body;
said periodic condition in the body synchronous with said detected
sound signals;
means for demodulating said detected sound signals to produce a
data signal representative of the average of the amplitude over a
selected past period of time;
Means for synchronizing said detected sound signals with said
periodic condition in the body synchronous with said detected sound
signals;
means for averaging a plurality of said demodulated signals over a
plurality of successive time periods to obtain an average of the
amplitudes of the demodulated signals; and
means for displaying said average of the amplitudes.
6. Apparatus as claimed in claim 5 wherein said means for averaging
comprises a time averaging computer.
7. Apparatus as claimed in claim 5 wherein said synchronizing means
comprises means responsive to the electrocardiographic signal of
said body.
8. Apparatus as claimed in claim 5 wherein said means for detecting
said sound signals comprises a microphone positioned near said
body.
9. Apparatus as claimed in claim 5 including means for filtering
said detected sound signals to pass signals in selected bands above
200 Hz and below 20,000 Hz.
Description
BACKGROUND OF THE INVENTION
Ausculation, i.e., the diagnostic monitoring of sounds made by
internal organs or internal bodily parts, has been employed down
through the years. The most widely used technique involves
listening to cardiovascular sounds, generally with a stethoscope,
and more recently with microphones, amplifiers and recording
oscillographs.
Relatively loud, low frequency sounds are easily detected by modern
stethoscopes, while very weak, higher frequency sounds are lost to
the diagnostician.
In addition to listening to a successive number of heartbeats,
gating techniques have been developed to listen to only portions of
each cycle of the heart. Also, techniques have been employed
wherein only the low frequencies of the sounds are detected, or
only the high frequencies at any one time.
However, in addition to the typical sounds and vibrations produced
by the pumping action of the heart, certain very weak, relatively
high frequency sound is produced by turbulence in the blood flow,
and this sound is not clearly detectable by present techniques.
Even when the high-frequency sounds are loud enough to be heard by
ausculation, the physician cannot accurately describe them.
The cardiovascular system of a human is so well designed that
normal yound persons are relatively free of any turbulent sounds.
However, even a healthy person with a good heart will usually
produce very brief bursts of turbulent sound as the various heart
valves close or open during each cycle of the heart. These sounds
are produced by a short burst or leakage of blood through a valve
just as it snaps shut or snaps open.
As the body ages, the blood system becomes less optimized and
conditions appear which result in turbulence which in turn result
in additional high frequency sounds. Most disorders of the heart
will also produce turbulence symptomatic of the disorder. For
example, a stenotic aortic valve or a mitral valve regurgitation
will produce distinctive turbulence sound. A septal defect caused
by congenital condition or by accident or disease permitting blood
flow between the right and left cavities of the heart, either the
atriums or the ventricose, will result in distinctive turbulence
noise.
In addition, poor circulation due to stenosis of the arteries will
produce turbulence in the blood flow through the blockage, and
sound is produced in high frequency components. It has been found
that over ninety percent (90 percent) of a coronary artery may be
occluded before a heart attack occur. Since this closure builds up
over a long period of time and produces turbulence noise during the
development period, early diagnosis based upon the detection of the
sound can lead to proper preattack treatment.
SUMMARY OF THE INVENTION
The present invention provides a novel method and apparatus whereby
the relatively high frequency sounds produced by turbulence in the
cardiovascular system, sounds heretofore lost to the diagnostician,
may be detected and recorded.
A sound transducer, such as a microphone, is positioned to pick up
the sounds from the body, and the relatively high frequency
components in a selected band, say from 800 to 1,200 Hz, are
separated out, amplified, and demodulated to obtain an envelope of
the amplitude of this sound. The demodulated output is transmitted
to a computer of average transients, or synchronized averager,
which is synchronized with a specific repetitive condition of the
cardiovascular system, such as the R wave of the electrocardiogram
(ECG). The demodulated signal output is thus synchronously averaged
over a plurality of sweep periods covering one cycle of the heart,
for example, 2.sup.6 or 2.sup.7 sweeps, to obtain a clear, smooth
average demodulated output trace of the sound. Environmental noise
and unsynchronized body noise are thereby eliminated from the
averaged signal.
The trace of the averaged signal will be a signature of the high
frequency turbulence sound, which in turn will be distinctively
related to the existing condition of the cardiovascular system.
In another embodiment, the sound signals are averaged without
demodulation to give useful information about the low frequency
sounds, even ones of sub-audible frequency.
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a block diagram of a preferred embodiment of the
apparatus used in the present invention.
FIG. 2 is a trace of the demodulated high frequency sounds produced
by turbulence in the cardiovascular system of an adult with a
normal, healthy heart and obtained using the technique of the
present invention.
FIG. 3 is a trace similar to that of FIG. 2 for a person that has
had at least one heart attack.
FIG. 4 is a trace similar to that of FIG. 2 for a person with a
late systolic murmur in idiopathic hypertrophic subaortic
stenosis.
FIG. 5 is a trace of the demodulated high frequency sounds obtained
for one cycle of the heart and without synchronous averaging over
repeated cycles.
FIG. 6 is a trace of the low frequency sound from a normal person,
without demodulation, averaged in a sycchronized signal
averager.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring now to FIG. 1, a microphone 11 is placed against the body
12 of the person being tested near the source of the noise to be
detected. For example, for heart disorders the microphone is placed
on the chest over the heart. If a stenosed artery is to be
examined, the microphone is placed as near to the occlusion as
possible.
The detected sound is amplified in pre-amplifier 13 and transmitted
to a band-pass filter 14 which passes only frequencies within the
selected high frequency rang of interest, for example 800 to 1,200
Hz. The frequency range is flexible and the limits are not
critical; selected bands within an overall range of from 200 to
20,000 Hz appear to be most useful. Bands can be selected to give
the best discrimination between one disease condition and
another.
The selected band of sound frequencies is amplified in amplifier 15
and delivered to a demodulator circuit 16 which rectifies and
filters the sound signal to produce an output signal proportional
to the running average of the amplitude of the sound in the
selected frequency band, this envelope having the form seen more
clearly in the traces of FIGS. 2-4 described below.
The demodulated sound signal is transmitted to a standard form of
synchronized signal averager 17 or computer of average transients,
for example the model HP 5480A instrument manufactured and sold by
Hewlett-Packard Co. of Palo Alto, Calif., the assignee of this
patent application. The synchronizing signal for the averager 17 is
obtained from a standard form of electrocardiograph instrument 18
coupled to the subject via three adhesive ECG electrodes 19. The
sync signal is delivered to the synchronous averager 17 from the
ECG instrument preferably at the initial rise of the R wave in the
heart cycle. Each demodulated sound signal averaged in the computer
circuit will be synchronized with the R wave, and by averaging over
a suitable number of sweeps or heart cycles, for example 2.sup.6 or
2.sup.7 sweeps, a very clean envelope signal is obtained for
recording on the display instrument 21.
It should be understood that the invention could take other forms;
for example the sound signal could be synchronized with other
periodic conditins, for example parts of the QRS complex other than
the initial rise of the R wave. Where there is no built-in sync
signal due to cyclic sound variations, as would be the case with a
venous stenosis, cyclic venous flow rates may be produced
artificially by mechanical means that repetitiously constrict the
vein. The synchronous averager would then be synchronized with the
mechanical means.
The synchronous averager could utilize analog or digital averaging
techniques. An alternative to synchronized averaging is to
cross-correlate successive scans of the demodulated high frequency
sounds.
There is shown in FIG. 2 the trace obtained with the apparatus of
the present invention from a person with a normal, healthy heart.
The sounds were measured with a microphone placed on the chest
directly over the heart. The beginning of the trace at point A on
the left hand side is synchronized with the early rise time of the
R wave of the ECG of the subject, and the total trace covers one
beat cycle of the heart. The trace is the average computed over
2.sup.7 successive heart beats.
The first peak is the envelope of the very brief turbulent sounds
made by the closing and opening of various valves just before the
ventricles of the heart commence pumping blood into the arteries.
The second peak is the envelope of the turbulence sounds made by
the valves as the ventricles cease pumping and begin filling.
The sounds are relatively high frequency and weak amplitude,
falling typically within the range over 400 Hz, and of a type not
heard with a stethoscope since they are well over the range in
which a stethoscope is sensitive. The well defined curve results
from the demodulation of the sounds and the repeated averaging of
the envelope obtained by the demodulation.
The trace shown in FIG. 3 was obtained under operating conditions
similar to those employed to obtain FIG. 2 except the subject was a
person with a late systolic murmur in idiopathic hypertrophic
subaortic stenosis. There was an overgrowth of heart muscle near
the outflow tract. The high frequency sound begins gradually at
about the time the heart begins to pump blood and builds up to its
loudest point just before the finish of the ventricular
contraction. Thus this slight constriction in the heart makes a
substantial murmur that is clearly defined as shown, building up
during systole to a late peak.
The trace of FIG. 4 was obtained from a person who has had at least
one coronary occlusion. The envelope of the sounds due to the
closing of the mitral and aortic valves are seen, although these
two peaks are not as crisp as those of FIG. 2. In addition, two
smaller peaks appear between the two valve sounds, these two
turbulent murmurs most probably being caused by damage left within
the heart arteries.
These traces serve to illustrate the many possible forms of traces
that can serve as signatures for the many different types of heart
disease. These sounds can be detected during routine physicals and
before serious damage occurs.
The advantage of synchronized time averaging over a relatively
large number of sweeps, as utilized to obtain FIGS. 2 through 4, is
seen by reference to FIG. 5 which is a trace of a single sweep of
the demodulated noise between 800 and 1,200 Hz obtained from a
subject. Although there is the appearance of a relatively loud
sound near the beginning of the sweeps, no peaks are very clearly
defined and the signature contains very little useful information
of the type obtained from repeated averaging of a plurality of
sweeps. Actually, the subject has a murmur which produces a noise
peak between the mitral and aortic valve peaks and which became
clear when 2.sup.7 sweeps were synchronously averaged.
Note that in this technique it is not necessary that a regular,
periodic heart rate exist, since the measured noise is synchronized
with the R wave which may itself be irregularly spaced.
The present invention will be most useful in the diagnosis of
septal defects, coronary artery disease, faults in prosthetic
valves, stenosis and regurgitation of valves, stenosis in
peripheral blood vessels, including veins, and aneurisms and
shunts. There is a definite possibility of the measurement of blood
pressures through the use of cuffs and partial occlusions, rapid
diagnosis of myocardial infarction by observing sound resonances,
quantitative measurement of blood velocity and physical dimensions
of biological structures, and improved display of
phonocardiograms.
In some cases, the sound signals are averaged in the synchronized
signal averager without demodulation, demodulator 16 having been
eliminated from the system, to give useful information about the
low frequency sounds, even ones of sub-audible frequency. A trace
of this type from a normal person is shown in FIG. 6, points A and
B, being typically 40-50 cycle components of the sound of the heart
valves, and the remaining sounds being the synchronously produced
sounds within the chest cavity.
* * * * *