U.S. patent number 3,760,812 [Application Number 05/126,145] was granted by the patent office on 1973-09-25 for implantable spiral wound stimulation electrodes.
This patent grant is currently assigned to The Regents of the University of Minnesota. Invention is credited to William E. Bradley, Gerald W. Timm.
United States Patent |
3,760,812 |
Timm , et al. |
September 25, 1973 |
IMPLANTABLE SPIRAL WOUND STIMULATION ELECTRODES
Abstract
Electrical stimulation electrodes for implantation within a
living body for transmission of stimuli to excitable neural or
contractile cells. The electrodes are characterized by flexibility
to permit following of contour variations and maintenance of
electrical contact with the stimulation region. The electrodes
include a pair of parallel spaced apart helically wound conductors
maintained in this configuration. When the electrode is implanted,
undesired excitation of nearby structures can be avoided.
Inventors: |
Timm; Gerald W. (Minneapolis,
MN), Bradley; William E. (Minneapolis, MN) |
Assignee: |
The Regents of the University of
Minnesota (Minneapolis, MN)
|
Family
ID: |
22423216 |
Appl.
No.: |
05/126,145 |
Filed: |
March 19, 1971 |
Current U.S.
Class: |
607/116; 174/130;
174/113C |
Current CPC
Class: |
A61N
1/05 (20130101) |
Current International
Class: |
A61N
1/05 (20060101); A61n 001/04 () |
Field of
Search: |
;128/404,416,418,419E
;174/113C,130 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Kamm; William E.
Claims
The embodiments of the invention in which an exclusive property or
privilege is claimed are defined as follows:
1. An electrical stimulation electrode for implantation in a living
body, said electrode consisting essentially of:
A. a pair of elongated parallel spaced apart helically wound
electrical conductors, said conductors being conductive
filaments,
B. means for supporting and maintaining said conductors in parallel
spaced apart helically wound configuration, said means
comprising:
1. a pair of elongated parallel spaced apart helically wound
insulative spacer strands, said spacer strands being alternated
with said conductors and wound in the same direction, and
2.
2. two pairs of elongated parallel spaced apart helically wound
insulative supporting strands, said supporting strands being wound
in the opposite direction from said conductors and spacer strands
and interwoven therewith, and
C. insulated conductor means for connecting said helically wound
conductors
to a source of electrical stimuli. 2. An electrical stimulation
electrode according to claim 1 further characterized in that said
conductors are spaced apart a distance about equal to the diameter
of the helical configuration.
3. An electrical stimulation electrode according to claim 2 further
characterized in that the spacing between said conductors and the
diameter of said helaical configuration are between about 1 and 3
mm.
4. An electrical stimulation electrode according to claim 1 further
characterized in that said insulative strands are formed from
nylon.
5. An electrical stimulation electrode according to claim 1 further
characterized in that said insulative strands are formed from
silk.
6. An electrical stimulation electrode according to claim 1 further
characterized in that said insulative strands are formed from
polyester.
7. An electrical stimulation electrode according to claim 1 further
characterized in that said conductors are formed from stainless
steel wire.
8. An electrical stimulation electrode according to claim 1 further
characterized in that said conductors are formed from platinum
wire.
9. An electrical stimulation electrode according to claim 1 further
characterized in that said conductors are formed from platinum
alloy wire.
10. An electrical stimulation electrode according to claim 1
further characterized in that said conductors are formed from
carbon impregnated polyester filament.
Description
The invention described herein was made in the course of work under
a grant or award from the Department of Health, Education and
Welfare.
This invention relates to implantable stimulation electrodes for
the application in a living body of a current of sufficient
magnitude in proximity of any desired excitable neural or
contractile cells to activate those neural or contractile cells in
the immediate vicinity of the electrode while avoiding excitation
of nearby structures. Although not limited thereto, the electrodes
are useful in bladder stimulation systems, of which those disclosed
in the patents of co-inventor William E. Bradley, U.S. Pat. No.
3,236,240 and No. 3,543,761, are exemplary.
Previous stimulation electrodes have included single or concentric
disc electrodes which are characterized by a lack of mechanical
flexibility which often causes them to lose electrical contact with
the stimulation region. Grid or mesh electrodes have electrical
characteristics which require the use of a backing sheet of
insulative material which cause the electrode to give
unidirectional stimulation. Such electrodes have the further
disadvantage that any large sheet covering a contractile organ in
the body causes a massive fibrotic reaction that ultimately impairs
the organ's contractile ability. Prior art electrodes have had the
further disadvantage of induction of wide current fields which
stimulate contiguous structures in an undesirable manner.
The electrode according to the present invention is flexible such
that it can follow contour variations in an organ without
interfering with the organ's normal contractile function. The
electrode may be embedded in the wall of the organ so that only
neural and contractile cells located within this wall will be
excited when electrical stimuli are applied. The electrode is
characterized by two parallel conducting wires extending in a
helical fashion and maintained in this configuration.
The invention is illustrated in the accompanying drawings in
which:
FIG. 1 is a diagrammatic illustration of one form of spiral wound
electrode with insulating core material;
FIG. 2 is a similar diagrammatic illustration showing the
approximate volume of tissue which is stimulated by a stimulus
applied in the use of the electrode;
FIGS. 3 and 4 are diagrammatic illustrations of the steps of an
imbrication technique for embedding the electrode in tissue to be
electrically stimulated; and
FIG. 5 is an illustration of an alternative form of electrode in
which conductor wires are interwoven with insulative spacing and
supporting strands.
Referring to FIG. 1, the electrode, indicated generally at 10, is
comprised of two parallel conducting wires 11 and 12 wrapped
helically around a flexible cylindrical insulative core 13. Current
flow between conductors 11 and 12 is provided through the tissue in
which the electrodes are embedded. The lead-in conductors 15 and 16
are insulated by flexible insulative tubes 17 and 18, respectively,
between the source of electrical stimuli and the body situs to be
stimulated by the electrode. By using a small diameter core,
between about 1 to 3 millimeters, and varying the spacing between
the two wires, the field confining properties of the electrode can
be varied.
The spatial relationship between conductors 11 and 12 may be
maintained by providing core 13 with shallow spiral channels or
grooves in which the conductors are wound; or the conductors may be
secured by means of adhesive material, such as medical grade
Silastic adhesive; or the conductor may be produced by printed
circuit techniques.
The flexibility of the electrode configuration is determined by the
mechanical properties of the core and of the wires. The wire can be
any implantable electrical current conductor, such as stainless
steel, platinum or one of its alloys, such as platinum-irridium,
carbon impregnated polyester (Dacron), or the like. The insulating
core is typically made from implantable grade silicone rubber,
nylon, silk, or other implantable insulating material. The
insulating tubes 17 and 18 for the lead-in wires are typically
implantable silastic or polytetrafluoroethylene (Teflon)
tubing.
As seen in broken lines in FIG. 2, experimentation has shown that
stimulus is effective within a volume described by a cylinder 20
concentric to the electrode 10, the diameter of the cylinder being
equal to the diameter D of the electrode plus twice the spacing S
between the helical wires (D + 2S) and with a height or length
equal to the electrode length L plus the cylinder diameter (L + D +
2S). As a general rule, the best confining properties of the
electrode are achieved when the spacing S between parallel wires 11
and 12 approximately equals the diameter D of the electrode. For
example, to stimulate the nerve net supplying the intestine or
urinary bladder, the electrodes were made with the spacing between
the conductors and diameter equal, and between about 1 and 3
millimeters. Stimuli were completely confined to the intestinal or
bladder wall during chronic implants of two months duration. The
tissue remained excitable during this time when stimulated at rates
between 10 and 40 pulses per second at pulse amplitudes below 50
volts. Intravesical pressure rises in excess of 60 centimeters
H.sub.2 O were typically obtained and complete bladder evacuation
was induced.
The electrode is so designed that it will follow contour variations
in an organ stimulated by it without interfering with the organ's
normal contractile function. Thus, by embedding the electrode in
the wall of an organ, only neural and contractile cells located
within this wall will be excited when electrical stimuli are
applied between the two wires in the electrode so that contraction
of only the stimulated organ will be accomplished. The electrode
can be surgically embedded by incision of the outer layers of the
organ to be stimulated, placing the electrode entirely in the wound
produced by the incision and suturing over it.
Alternatively, as shown in FIGS. 3 and 4, the electrode 10 may be
positioned on the surface 21 of the organ by means of sutures 22.
The sutures 22 are passed into and out of the tissue 23 of the
organ on one side of the electrode, passed over the electrode and
then into and out of the tissue on the opposite side, as shown in
FIG. 3. Then, as shown in FIG. 4, the electrode 10 is imbricated in
the tissue by pulling the opposite ends of the suture 22 together
around and over the electrode, and the ends of the suture are tied.
This, of course, is repeated as required along the length of the
electrode.
An alternative embodiment of the stimulation electrode according to
the present invention is shown in FIG. 5. According to this
embodiment, the conductor wires 11A and 12A, here shown as solid
black lines, are interwoven with six strands of small diameter
insulative strands such as braided nylon suture, silk, polyester,
or the like. Conductors 11A and 12A are wrapped helically in
parallel spaced relation, with the spacing between conductors
approximately equaling the diameter of the electrode, as already
described. In order to maintain the conductors spaced from one
another, a pair of insulator spacer strands 25 and 26 are wrapped
in the same helical fashion spaced between the adjacent winds of
the conductors. These insulative strands 25 and 26 are shown as
being stippled, for greater clarity.
The conductor wires 11A and 11B and alternating spacers 25 and 26
are maintained in the described relationship by means of four
insulative strands 27-30 helically wound in the opposite direction
from the conductor and spacer strands with substantially the same
spacing and interwoven with the conductors and spacers. Thus it
will be seen that one supporting strand is interwoven so as to pass
under each conductor wire and over each spacer strand. The next
adjacent supporting strand is interwoven to pass over each
conductor wire and under each spacer strand and so on for the
length of the electrode. The result is a symmetrical tubular
configuration in which the helical spatial relationship of the
conductor wires is maintained and separation of the wires is
assured. A flexible insulative core may be within the electrode or
not, as desired. For convenience the woven electrode is shown as
formed on an elongated cylindrical core or mandrel which may be
removed before the electrode is put into use. Conductors are
provided with insulated lead-ins for connection to a source of
electrical stimuli. This form of electrode may be imbricated in the
manner already described.
It is apparent that many modifications and variations of this
invention as hereinbefore set forth may be made without departing
from the spirit and scope thereof. The specific embodiments
described are given by way of example only and the invention is
limited only by the terms of the appended claims.
* * * * *