U.S. patent number 3,742,988 [Application Number 05/873,201] was granted by the patent office on 1973-07-03 for apparatus and method for dissolving soluble gas in a liquid.
This patent grant is currently assigned to Nuclear Medical Computer Corp.. Invention is credited to George S. Kush.
United States Patent |
3,742,988 |
Kush |
July 3, 1973 |
APPARATUS AND METHOD FOR DISSOLVING SOLUBLE GAS IN A LIQUID
Abstract
A container having a sealable access opening, an inlet conduit
and an outlet conduit with a valve therein and a plunger threadedly
engaged through the housing for breaking a glass ampule containing
a soluble gas within the housing from the exterior thereof. The
housing is flushed and filled with a desired fluid, the ampule is
broken and the solution of fluid and soluble gas is drawn from the
housing as desired.
Inventors: |
Kush; George S. (Burnsville,
MN) |
Assignee: |
Nuclear Medical Computer Corp.
(Minneapolis, MN)
|
Family
ID: |
25361168 |
Appl.
No.: |
05/873,201 |
Filed: |
November 3, 1969 |
Current U.S.
Class: |
141/2; 141/25;
250/303; 250/432R; 600/1; 141/105; 261/121.1; 604/24 |
Current CPC
Class: |
G01N
1/38 (20130101) |
Current International
Class: |
G01N
1/38 (20060101); B01l 005/00 () |
Field of
Search: |
;23/259 ;128/1.1,272
;141/1,2,4,5,9,18,21,25-27,37,11,69,100,105,107,114 ;169/6-8,32
;222/80 ;250/16R,16T ;261/1,121 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Geiger; Laverne D.
Assistant Examiner: Earls; Edward J.
Claims
What is claimed is:
1. Apparatus for dissolving a substantially soluble gas contained
in a sealed, breakable ampule in a liquid comprising:
a. a housing having a cavity therein with an access opening and a
removable cover sealingly engaged over the opening;
b. means mounted within the cavity of said housing and operable
from the exterior of said housing to break an ampule positioned
within the cavity;
c. inlet and outlet means communicating with the cavity in said
housing for introducing liquid into the cavity and removing liquid
and dissolved gas from the cavity, respectively; and
d. filter means mounted in the outlet for removing foreign material
from the liquid and dissolved gas as it is removed from the
cavity.
2. Apparatus as set forth in claim 1 wherein the outlet means
includes a fitting for receiving a syringe in sealed engagement
therewith and in communication with the cavity in the housing
through the outlet means.
3. Apparatus as set forth in claim 1 wherein the filter means
includes a microporous filter element.
4. Apparatus for dissolving a substantially soluble gas contained
in a sealed, breakable ampule in a liquid comprising:
a. a housing having a cavity therein with an access opening and a
removable cover sealingly engaged over the opening;
b. a portion of the cavity in said housing being designed for
receiving an unbroken, gas filled ampule therein and maintaining
the ampule in a desired orientation;
c. a member threadedly engaged in said housing with a portion
thereof external of said housing and a portion extending within the
cavity, said member being movable between a first position in which
the ampule is not engaged and a second position in which the ampule
is engaged and broken;
d. inlet means communicating with the cavity in said housing for
introducing liquid into the cavity;
e. outlet means communicating with the cavity adjacent the
uppermost portion of the cavity for removing a solution of liquid
and dissolved gas from the cavity;
f. microporous filter means mounted in the outlet means for
removing foreign material from the solution as it is removed from
the cavity; and
g. valve means in the outlet means adjustable to allow and prevent
the flow of liquid therethrough.
5. Apparatus as set forth in claim 4 wherein the portion of the
threadedly engaged member extending within the cavity includes a
surface parallel with and in juxtaposition to the inner surface of
the cavity having sealing means thereon, said parallel surface
sealingly engaging the inner surface of the cavity with the
threadedly engaged member in the first position for preventing the
escape of gas between the housing and the threadedly engaged
member.
6. A method of dissolving a substantially soluble gas contained in
a sealed, breakable ampule in a liquid comprising the steps of:
a. placing the ampule in a sealed container having a liquid inlet
and an outlet for the solution of liquid and gas, which outlet has
valve means therein adjustable between open and closed positions,
said container further having a member movable from the exterior of
the container to engage and break the ampule;
b. applying a source of the desired liquid to the inlet of the
container and opening the outlet valve to fill the container with
the desired liquid and flush all undesirable material from the
container;
c. maintaining the source of the desired liquid in communication
with the inlet and closing the outlet valve;
d. moving the member to break the ampule within the liquid filled
container; and
e. applying a syringe to the outlet, opening the outlet valve and
drawing out a desired amount of the solution.
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
In some fields it is necessary to dissolve a soluble gas in a
liquid without allowing any substantial quantities of the gas to
escape and, in some instances, without allowing the gas or the
ultimate solution to come into contact with any foreign objects or
material, such as the operator, the atmosphere, etc. This is
especially true in the medical field.
The present apparatus and method were developed to dissolve the
radioisotope .sup.133 xenon, which is purchased in the gaseous
state, in a sterile saline solution. In this particular instance it
is imperative that the gas is isolated from the individual
performing the task, because of the radiations from the
radioisotope, and that the ultimate solution is isolated from the
atmosphere, because it must be maintained sterile. .sup.133 xenon
is obtained in glass ampules containing a volume of about 5 cc of
gas at a pressure of approximately 10 mm of mercury. The ampule is
wrapped in a lead foil to minimize radiation exposure to personnel
handling the ampule.
2. Description of the Prior Art
A prior art method of dissolving .sup.133 xenon in a saline
solution is described in the following two publications:
Loken, M. K. and Westgate, H. D.: Evaluation of pulmonary function
using xenon-133 and the scintillation camera. Am. J. Roentgen.,
Rad. Ther. and Nuclear Med. 100:835, 1967.
Loken, M. K. and Westgate, H. D.: Using xenon-133 and a
scintillation camera to evaluate pulmonary function. J. of Nuclear
Med. 5:45, 1968. Unfortunately, this prior art method is only
approximately 35 percent efficient, is difficult to set up and
requires that the transfer apparatus be kept in a laboratory
exhaust hood because of the finite chance of loss of the
radioactive gas.
SUMMARY OF THE INVENTION
The present invention pertains to apparatus for dissolving a
substantially soluble gas contained in a sealed breakable ampule in
a liquid including a container having a liquid inlet and outlet
with valve means therein, a sealable access opening and a member
movable from the exterior of the container to engage and break the
ampule when the container is filled with the desired liquid.
It is an object of the present invention to provide improved
apparatus for dissolving a substantially soluble gas contained in a
sealed breakable ampule in a liquid.
It is a further object of the present invention to provide
apparatus for dissolving soluble gas in a liquid, which apparatus
is sealed to prevent leakage of undissolved gases.
It is a further object of the present invention to provide
apparatus for dissolving a soluble gas in a liquid, which apparatus
is relatively efficient, inexpensive to manufacture and simple to
operate.
It is a further object of the present invention to provide an
improved method of dissolving a soluble gas in a liquid while
maintaining the liquid sterile and the operator free from exposure
to the gas.
These and other objects of the present invention will become
apparent to those skilled in the art upon consideration of the
accompanying specification, claims and drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
Referring to the drawings, wherein like characters indicate like
parts throughout the figures:
FIG. 1 is a view in top plan of the present apparatus with syringes
connected to the inlet and outlet;
FIG. 2 is a view, somewhat diminished in size, as seen generally
from the line 2--2 in FIG. 1;
FIG. 3 is a sectional view as seen from the line 3--3 in FIG. 1;
and
FIG. 4 is a view similar to FIG. 3 with the movable parts in a
different position.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring more specifically to the drawings the numeral 10
generally designates a container including a generally cylindrical
housing 11 having a cylindrical cavity 12 therein, opening axially
outwardly at one end of the housing 11, and a cover 13 sealingly
engaged with the housing 11 to close the cavity 12. The container
10 is adapted to be positioned with the cavity 12 opening upwardly
and a generally coaxial well 15, having a substantially smaller
diameter than the cavity 12, is formed in the lower end of the
cavity 12. An inlet passageway 16 is formed in the side of the
housing 11 so as to communicate with the lower end of the well 15.
It should be understood that the inlet passageway 16 might
communicate with the well 15 at a different position but the
illustrated position was chosen because it insures a complete
flushing of the cavity 12 when fluid is injected through the
passageway 16, as will become apparent presently. The well 15 is
designed to receive a pointed end of an ampule 20 therein with the
ampule extending into the cavity 12 above the well 15, as
illustrated in FIG. 3. Further, the ampule 20 fits into the well 15
so that liquid from the inlet passageway 16 can flow freely
therearound and the ampule 20 is maintained in the upright
position.
Adjacent the upper end of the housing 11 a radially outwardly
extending step is formed in the wall of the cavity 12 around the
entire periphery thereof. Further, a radially outwardly extending
flange 25 is formed as an integral part of the housing 11 at the
upper end thereof adjacent the radially outwardly extending step in
the cavity 12. An outlet passageway 26 extends through the housing
11 and into communication with the cavity 12 adjacent the radially
outwardly extending step therein. As will become apparent
presently, the outlet passageway 26 is adjacent the inner surface
of the cover 13 so that all air and other foreign material can be
flushed from the cavity 12 by injecting fluid into the inlet
passageway 16 and allowing the foreign materials and fluid to pass
out through the outlet passageway 26.
The cover 13 is formed in a generally disk shape with the radius
thereof being approximately equal to the radius of the flange 25.
The bottom surface of the cover 13 is formed with a generally
axially outwardly extending step 30 therein generally circular and
coaxial with the cover 13 and housing 11. The radius of the step 30
is slightly smaller than the radius of the radially outwardly
extending step in the cavity 12 and mates therewith so that the
cover 13 engages the upwardly directed surfaces of the housing 11
and forms an upper wall for the cavity 12 at the radially outwardly
directed step therein. A plurality of internally threaded, upwardly
opening holes are provided in the flange 25 and screws 31 are
threadedly engaged therein through axially extending holes in the
cover 13 to hold the cover 13 firmly in place. A circumferentially
extending upwardly opening groove is formed in the upper surface of
the radially outwardly extending step in the cavity 12 and a
resilient O-ring 32 is positioned therein to form a seal between
the housing 11 and the cover 13. As previously described, the
outlet passageway 26 communicates with the cavity 12 at the
downwardly directed surface of the step 30 in the cover 13.
A circular well is formed coaxially in the upper surface of the
cover 13, which well extends axially downwardly into the cover 13.
A pressure disk 35 having a radius slightly smaller than the radius
of the well in the cover 13 and an axial width substantially
smaller than the axial depth of the well, is positioned in the well
adjacent the bottom thereof. A second disk 36, similar in shape to
the pressure disk 35, is positioned within the well in overlying
relationship to the disk 35. A plurality of holes are provided
through the disks 35 and 36 and axially aligned internally threaded
holes are formed in the cover 13 so that screws 37 inserted through
the holes in the disks 35 and 36 engaged into the cover 13,
maintain the disks 35 and 36 in tight overlying relationship. An
axially aligned opening is formed through the disk 36, pressure
disk 35 and cover 13 and the hole is internally threaded for
reasons which will become apparent presently.
An externally threaded elongated shaft 40 is threadedly engaged in
the hole through the disks 35 and 36 and the cover 13 so that one
end thereof extends into the cavity 12 and the other end is
accessible external of the container 10. The internal end of the
shaft 40 has a disk 41 generally coaxially affixed thereto for
axial movements within the cavity 12 in response to rotation of the
shaft 40. The upper surface of the disk 41, or the surface adjacent
the lower surface of the cover 13, has a peripheral groove therein
with a resilient O-ring 42 engaged therein. The O-ring 42 provides
a seal between the disk 41 and the cover 13 when the shaft 40 is
rotated outwardly as far as it can be. The O-ring 42 prevents the
egress of any fluid or gas from the container 10 between the shaft
40 and the cover 13. The pressure disk 35 is formed of some
material which is slightly compressible, such as some of the
tetrafluoroethylene fluorocarbon resins sold under the trademark
"Teflon" and the like, so that a seal is provided between the cover
13 and the shaft 40 when the disk 36 is engaged tightly against the
pressure disk 35 by the screws 37. Thus, with the cover 13
sealingly engaged on the housing 11 the container 10 is
substantially sealed and the shaft 40 is movable from the exterior
of the container 10 to a position where the disk 41 within the
cavity 12 engages and breaks the ampule 20.
Referring to FIG. 1, the inlet passageway 16 has an adapter 50
affixed thereto with a lock 51 associated therewith for receiving
the needle of a syringe 52 therein and sealingly engaging the end
of the syringe 52. In this embodiment the relatively large syringe
52 is utilized as a supply of a desired liquid but it should be
understood that other devices might be utilized as a supply. The
adapter 50 provides communication between the syringe 52 and the
cavity 12 and prevents contact of the fluid in the needle with the
atmosphere.
The outlet passageway 26 has a microporous filter element 55
connected in communication therewith, the outlet of which goes to a
valve 56. The microporous filter element 55 may be any type of
element which will filter various foreign material, such as glass
particles, bacteria, etc., from the solution passing through the
outlet passageway 26. Typical microporous filter disks are sold
under the trademark "Millipore" and have a 25 mm diameter with 0.45
micron pores therethrough. The valve 56 has an adapter 57 and lock
58 associated therewith for receiving a syringe 59 therein similar
to the adapter 50 and lock 51. The syringe 59 is utilized to draw a
desired amount of solution from the container 10 with the valve 56
open.
In the operation of the present apparatus, the container 10 and the
inlet and outlet passageways 16 and 26 with the adapters 50, 57 and
valve 56, all of which are formed of some suitable material such as
stainless steel, are sterilized by autoclaving or the like. An
ampule 20 containing .sup.133 xenon is then sterilized by some
convenient method, such as immersing it in an aqueous zepharin
chloride solution 1.750 for approximately 60 minutes. After the
ampule 20 is properly sterilized it is placed in the cavity 12 with
the pointed end thereof engaged in the well 15 to hold the ampule
20 in an upright position. The cover 13 is then sealingly engaged
on the housing 11 and the large syringe 52 filled with a sterile
saline solution is affixed in the adapter 50. The valve 56 is
opened and saline solution is forced from the syringe 52 into the
cavity 12 to flush all air and other foreign materials therefrom.
With all air removed from the cavity 12 the valve 56 is closed and
the shaft 40 is rotated until the disk 41 engages and breaks the
ampule 20. The shaft 40 is then immediately rotated in a reverse
direction until the O-ring 42 in the upper surface of the disk 41
engages the cover 13 to insure a good seal between the cover 13 and
the shaft 40.
With the ampule 20 broken the soluble gas therein dissolves in the
saline solution within the cavity 12. The smaller syringe 59 is
then engaged in the adapter 57 and the valve 56 is opened to allow
solution to be withdrawn from the container 10 as required. As
solution is withdrawn from the container 10 by the syringe 59 new
sterile saline solution is automatically injected by the syringe
52. In the present embodiment, with the size of ampule described,
the inside dimensions of the cavity 12 are approximately a 4 cm
diameter and a 5 cm height. Assuming complete mixing of the
replacement saline solution, the concentration of the xenon-saline
solution in the cavity 12 decreases according to the following
formula:
C.sub.v = C.sub.o e - (Q/V)
where C.sub.v = residual concentration in the container 10 after
the removal of the dose, measured in millicuries per milliliter
(mC.sub.i /ml)
C.sub.o = the original concentration correct for decay (mC.sub.i
/ml).
Q = total volume of saline solution removed to date (ml)
V = volume of the container 10 (ml).
In general, C.sub.o is approximately equal to 15 mC.sub.i /ml at
the time the gas is dissolved in the saline solution. It should be
understood that gases other than .sup.133 xenon might be used in
the present apparatus and, depending upon the amount of gas
utilized and the type, the size and material utilized for the
container 10 and the concentrations may vary considerably.
Thus, apparatus is disclosed wherein a soluble gas can be dissolved
in a liquid with little or no danger of the gas escaping or of
contaminating the ultimate solution. Further, the apparatus is
relatively inexpensive to manufacture, simple to operate and
requires no additional elaborate equipment because of its inherent
safety features.
* * * * *