U.S. patent number 3,739,779 [Application Number 05/032,547] was granted by the patent office on 1973-06-19 for hypodermic syringe and needle construction.
This patent grant is currently assigned to Medical Electroscience & Pharmaceuticals, Inc.. Invention is credited to Frederick W. Pfleger.
United States Patent |
3,739,779 |
Pfleger |
June 19, 1973 |
HYPODERMIC SYRINGE AND NEEDLE CONSTRUCTION
Abstract
A hypodermic syringe and needle construction comprising threaded
actuating means mounted on the end of a syringe ampule and adapted
to provide a mechanical advantage for piercing a needle and needle
holder unit through a piercable end closure. In another facet of
the invention, a ball-type closure is provided in a disposable
ampule unit, the unit including threaded actuating means on the
distal end of the ampule for moving the needle holder to dislodge
the ball in the closure and permit fluid communication between the
contents of the ampule and the lumen of the needle. A non-coring,
discrete needle and holder construction, adapted to be stored as a
separate unit from a syringe or ampule, has a hypodermic needle
provided with solid piercing means extending beyond the lumen of
the needle for initially piercing the end closure of an ampule
without producing a coring action, facilitating passage of the
lumen of the needle through the pierced closure without creating a
core, the needle holder being adapted to substantially rigidly,
sealingly engage the discharge end of a syringe or ampule.
Inventors: |
Pfleger; Frederick W. (Cherry
Hill, NJ) |
Assignee: |
Medical Electroscience &
Pharmaceuticals, Inc. (Cherry Hill, NJ)
|
Family
ID: |
21865515 |
Appl.
No.: |
05/032,547 |
Filed: |
April 28, 1970 |
Current U.S.
Class: |
604/205; 604/241;
604/411; 401/134; 604/274 |
Current CPC
Class: |
A61M
5/288 (20130101); A61M 5/3291 (20130101); A61M
5/3202 (20130101) |
Current International
Class: |
A61M
5/28 (20060101); A61M 5/32 (20060101); A61m
005/00 () |
Field of
Search: |
;128/218NV,218D,218DA,218M ;401/134 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Michell; Robert W.
Assistant Examiner: Heinz; A.
Claims
I claim:
1. A non-coring disposable hypodermic syringe comprising, a tubular
body for holding fluids and having a first end and a second end, a
movable plunger capable of being moved into said body and sealing
said first end, a piercable end closure sealing said second end of
said body, a needle holder with a non-coring hollow needle secured
therein, said needle holder adapted to telescopically fit onto said
second end of said body when the hypodermic syringe is assembled,
said needle having an inner end adapted to protrude through said
piercable end closure when the syringe is assembled and an outer
end projecting outwardly of said needle holder, said hollow needle
permitting fluid communication between the fluid within the tubular
body and the otuer end of the needle for administering injectable
fluids to humans or animals, said needle further including a
piercing element secured to said needle between said inner end and
said needle holder, said piercing element projecting longitudinally
beyond said inner end of said needle and adapted to prepierce said
piercable end closure so as to prevent a core cut from the
piercable end closure from obstructing the passage of fluid through
said needle when said needle holder is fitted onto said second end
of said tubular body.
2. A non-coring disposable hypodermic syringe according to claim 1
wherein said piercing element is substantially planar.
3. A non-coring disposable hypodermic syringe according to claim 1
wherein said piercing element is substantially semi-circular.
4. A non-coring disposable hypodermic syringe according to claim 1
including a retainer cap to secure said piercable end closure to
said body, a ring on said needle holder adaptable to said retainer
cap wherein said piercing element is guided to pierce said
piercable end closure on sliding said ring onto said retainer
cap.
5. A non-coring disposable hypodermic syringe according to claim 1,
including a retainer cap to secure said piercable end closure to
said body, a threaded surface on said retainer cap, a matching
threaded surface on said needle holder wherein rotation of said
needle holder on said cap provides the rotational and axial
movement to pierce said piercable end closure.
Description
THE FIELD OF THE INVENTION
This invention relates to disposable hypodermic syringes and
ampules which are used in the administration of medicaments or
injectable fluids to humans or animals. Particularly, the invention
is directed to a syringe or ampule construction, and a needle and
needle holder construction, which are designed to produce an
optimum mechanical advantage for introducing the needle into the
syringe or ampule through a resealable closure without creating any
sudden release of fluid under pressure at the moment of insertion
of the needle through the end closure. The disposable hypodermic
syringes which exist are of two types. The first type is
pre-sterilized empty disposable syringe, in which the person
administering the medicament or injectable fluid transfers the
required amount of that liquid from a bulk container to the syringe
prior to injection, after which injection the entire syringe
assembly is discarded. The second type of disposable syringe is
that in which the medicament or injectable fluid is pre-filled in
the syringe under production filling conditions. Another type of
syringe is a reusable syringe, which is loaded with a disposable
ampule which has been pre-filled with medicament or injectable
fluid, and which also utilizes a disposable needle. The two latter
types of syringe have many advantages over the former, such as
printing the identification of the medicament or fluid and dosage
thereof in clear, identifiable language on the syringe or ampule,
and the limiting of contamination of the contents of the syringe or
ampule under production filling and handling techniques. These
contrast with the increased likelihood of contamination which
occurs when the person administering the liquid fills the
syringe.
THE PRIOR ART
It is necessary, in order to preserve the sterility of the contents
of pre-filled syringes and ampules, and to preserve the sterility
of the interior of non-pre-filled syringes, that the syringe or
ampule be sealed in such a manner as to avoid any contact with the
atmosphere. This is best accomplished by maintaining the needle as
a separate unit from the syringe unit prior to use. This separation
is also necessary because of the desirability of using various
sizes of needles with different fluids, as a result of which it is
more economical to separately produce and sell the syringes or
ampules and the needle units. Furthermore, many injectable liquids
have a corrosive reaction with the metal of which hypodermic
needles are typically made, so that it is desirable to maintain the
needle out of contact with the liquid for any prolonged period of
time prior to administration of a medicament or other
injectable.
It has long been recognized as being desirable to provide a
hypodermic needle which will pierce a piercable end closure of a
syring or ampule, to provide convenient assembly of the needle onto
a hypodermic syringe unit. Many prior art devices are known for
achieving this result. For example, U.S. Pat. No. 3,380,449
discloses one such type of unit, in which the needle is
manufactured as an integral portion of the ampule and closure
assembly, and a conventional, double-pointed needle is used to
pierce the necked-down section of an ampule stopper. U. S. Pat. No.
2,688,966 shows a similar construction as part of a reusable
syringe which uses disposable ampules, and in which the
double-pointed needle is screwed on the syringe and has one end
which penetrates the ampule stopple. Other types of devices, one
example of which is shown in U.S. Pat. No. 3,115,136, entail the
incorporation, as an integral part of the ampule unit, of a needle
holder assembly which is designed to dislodge a ball which is
mounted in the ampule closure, which closure is sometimes
piercable. The former two types of constructions have the
disadvantage of causing coring of the syringe or ampule closure, by
the sharp, pointed end of the syringe, cutting a core from the
closure as it passes therethrough. This core may obstruct the lumen
of the needle, and therefore prevent administration of the
medicament or injectable fluid, or alternatively, under the
pressures of administration, might be forced through the needle
into the patient with the attendant possibility of contamination,
or of injury to the patient, such as by creating a venal or
arterial obstruction. One disadvantage of the latter type of needle
construction, involving the dislodging of a ball, is the
possibility of pre-ejection of liquid at the moment that the ball
seal is released, under the considerable forces necessary to
dislodge the ball. This latter, ball-type construction is also much
more expensive to manufacture than the other types constructions.
because of the expense of the elements of the unit and of the
assembly thereof. The ball-type units are also more subject to
contamination than is a unit incorporating a one-piece end closure.
In those constructions of prior art pre-filled syringes of the
former type, there is also a possibility of pre-ejection of fluid
at the moment of entry of the needle Into liquid communication with
the ampule interior.
Brief summary of the invention and advantages over the prior
art
the hypodermic needle and syringe construction of this invention
overcome the disadvantages of the prior art of possible
contamination, expensive construction, coring, and pre-ejection of
liquid, by providing a needle construction which is inexpensive,
which will not core, which is not susceptible to contamination
during manufacture, which need not be stored as an integral part of
the syringe assembly, and which, in one embodiment of the
invention, is provided with a substantial mechanical advantage such
that communication between the needle lumen and ampule or syringe
interior can be gradually achieved to avoid an abrupt,
high-pressure communication and possible pre-ejection of
liquid.
In one aspect of the invention, an ampule or a syringe is provided
with a piercable end closure, and the ampule or syringe and needle
may be pre-assembled as a single unit. The distal end of the ampule
or syringe is provided with a sealing cap, having a threaded inner
surface, which engages a mating threaded inner surface of the
needle holder. The proximal end of the needle extends below the
main surface of the needle holder, and the needle may be
constructed to provide a non-coring, piercing penetration of the
end closure, or, alternatively, to dislodge a sealing ball mounted
in the end closure. The needle unit may be pre-packaged as an
integral part of the syringe or ampule unit, or may be screwed into
the sealing cap immediately prior to its use. Communication between
the needle lumen and syringe or ampule contents is achieved by
rotating the needle unit until communication is obtained. The
mechanical advantage provided by the matingly threaded members
facilitates gradual communication between the needle and the
syringe or ampule contents, thereby avoiding the likelihood of
pre-ejection of liquid therefrom. In one embodiment of the
invention, the needle is provided with non-coring entry means at
its proximal end for piercing the syringe or ampule piercable end
closure, to provide an easy communication between the syringe or
ampule interior and the needle, without coring, and without
pre-ejection of liquid. In this embodiment, the needle holder and
needle cap may be lockingly constructed, so that rotation of the
cap will rotate the holder, for insertion of the needle into the
ampule or syringe without contaminating the needle.
Another aspect of this invention resides in a needle construction
which is adapted to be used with a disposable hypodermic syringe or
ampule, which needle is of a design such that no coring is produced
upon entry of the needle through the syringe or ampule end closure,
and which, in one embodiment, allows the needle and needle holder
to be constructed as a separate unit from the syringe or ampule
which can readily be produced and stored in a variety of needle
sizes, with a single size of holder which can be rigidly, sealingly
secured to any suitable syringe or ampule. The needle unit of this
invention is provided with a lumen which terminates in-board the
proximal end of the needle unit, such that the needle unit has a
solid end member which initially pierces the end closure of a
syringe or ampule, to form a suitable aperture for passage of the
needle, whereby no core is or can be produced during entry. In one
embodiment of the invention, the needle has a closed proximal end,
which may be formed by collapsing the normally open proximal end of
a conventional needle and then sharpening the same to produce a
piercing point. The fluid inlet near the proximal end of the needle
is spaced from that point at the proximal end, and is formed by
grinding an aperture through the side wall of the needle to the
lumen. In another embodiment of the invention, a conventional
needle having a lumen which extends from one end to the other, and
having one or two pointed ends, is provided with a pointed piercing
member formed integrally therewith, and extending about one-half
inch beyond the proximal end of the needle. The piercing member is
preferably of such size that it produces a slit, slightly wider
than the outside diameter of the needle, which is large enough to
permit convenient passage of the needle through the end closure,
while maintaining an adequate tight seal around the needle to avoid
leakage. The needle holder is of such design that, upon entry of
the needle through the syringe or ampule end closure, the needle
holder is tightly secured to the distal end of the syringe or
ampule, to provide a firm unitary combination of the two at the
time that the syringe or ampule is to be used for fluid
administration.
Therefore, it is an object of this invention to provide a
hypodermic needle construction which will not produce coring.
Another object of this invention is to provide a non-coring
hypodermic needle and needle holder construction which may be
manufactured and stored as separate units from the ampules or
syringes with which they may subsequently be used, and which will,
when assembled, provide a rigid, sealed assembly.
Yet another object of this invention is to provide a needle holder
and syringe or ampule combination construction, which is provided
with a considerable mechanical advantage, to facilitate gradual
communication between a hypodermic needle lumen and a sealed ampule
or syringe interior, to avoid pre-ejection of the contents of the
ampule or syringe.
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a cross-sectional view of a pre-filled hypodermic syringe
adapted for use with the needle and holder in this invention;
FIG. 2 is a cross-sectional view of a preferred embodiment of the
non-coring needle and needle holder of this invention, adapted to
be used with the syringe of FIG. 1;
FIG. 3 is a cross-sectional view, showing the needle holder of FIG.
2 seated on the end of the syringe of FIG. 1, with the needle
inserted in fluid communication with the syringe interior;
FIG. 4 is a fragmentary side view of the proximal end of the
non-coring needle of FIG. 1;
FIG. 5 is a fragmentary top plan view of the proximal end of a
modified embodiment of non-coring needle, which may be used with
the needle holder construction of FIG. 2;
FIG. 6 is an end view of the non-coring needle embodiment of FIG.
5;
FIG. 7 is a fragmentary top plan view of the proximal end of
another embodiment of non-coring needle of this invention;
FIG. 8 is an end view of the non-coring needle embodiment of FIG.
7;
FIG. 9 is a fragmentary cross-sectional view of a preferred
embodiment of a combined syringe and needle construction in
accordance with this invention, showing the position of the needle
prior to piercing the syringe end closure;
FIG. 10 is a fragmentary view, of the unit of FIG. 9, showing the
needle in fluid communication with the contents of the syringe;
and
FIG. 11 is a fragmentary cross-sectional view of another embodiment
of the invention shown in FIG. 8, showing the position prior to
displacing the ball out of the end closure.
As seen in FIG. 1, the syringe 100 comprises a plastic or glass
cartridge 110 in which a liquid, which may be a medicament or other
injectable fluid, is maintained in sealed condition. The proximal
end of syringe 100 is sealed with a piston or plunger 111 which is
made of rubber or a matching ground glass surface, and which is
attached at the end of a syringe plunger rod 115. The other end of
syringe 100 is formed with a reinforced, reduced diameter, neck
section 101, over the end of which resealable rubber diaphragm 112
is sealingly held by a sealing ring 113. Sealing ring 113 has an
aperture 116 which provides access to the central outer surface of
the rubber diaphragm 112 for entry of a hypodermic needle. Sealing
ring 113 is provided with an annular groove 114, which engages the
edge of diaphragm 112, and the purpose of which will be more fully
discussed hereinafter. The general construction of the disposable
syringe, insofar as the syringe material, the piston and syringe
plunger construction, and the manner of fastening the rubber
diaphragm 112 about the neck 101 of the syringe with an annular
sealing ring 113, are well known in the art, and do not form any
part of this invention.
As seen in FIG. 2, hollow needle 201 is mounted in a needle holder
202, in such manner that a substantial length 207 of the needle 201
projects in front of the needle holder 202, for insertion into a
human or animal for administration of medicament or other
injectable fluid. The needle holder 202, which is formed of
moldable, slightly yieldable plastic material, such as is provided
with a depending annular skirt 208 which extends slightly beyond
the proximal, pointed end 206 of needle 201. The skirt 208 is
provided, at its upper extremity, with an annular inwardly
extending lip 205, which is designed to lockingly, sealingly seat
in recessed portion 114 of annular ring 113. The interior diameter
204 of the annular skirt 208 is approximately the same as the outer
diameter of annular ring 113, and the needle holder 202 is formed,
as noted, of somewhat yieldable plastic material, such that the lip
205 will releasably, tightly seat in groove 114, and the skirt will
snugly engage annular ring 113, when the needle holder is in the
administering position shown in FIG. 3. Hypodermic needle 201 has a
closed pointed end 206, and fluid communication with the
fluid-receiving portion of the needle 201 is provided through side
opening 210, which is preferably located at least one-quarter inch
from the point on end 206, as best seen in FIG. 4.
One manner of forming needle 201 is by taking a conventional
hypodermic needle which is pointed at both ends, or which has one
flat end and collapsing the proximal end (the flat end in a needle
having only one point) and grinding a point thereon, to provide a
closed, pointed proximal end 206. An aperture 210 is then ground
through the side wall of needle 201 to provide fluid communication
between the needle exterior near the proximal end of the needle and
the lumen 211 of the needle.
Prior to use, the needle and needle holder unit 201, 202 would
preferably be stored in a sterilized package. Sterility of the
needle 201 could be achieved by providing an end cap for the skirt
portion 208 of the needle holder, and a needle cap which would
sealingly seat around one of the annular surfaces 209 or 212 at the
distal end of the needle holder. Needle caps and end closures of
this sort are well known in the art, and form no part of this
invention. Alternatively, sterility could be maintained by
packaging sterilized needle and holder units 201, 202 in a
pre-sterilized, sealed envelope in a manner which is well known in
the art.
In use, the end cap and needle cover would be removed from the
needle holder, and the exposed surface of syringe diaphragm 112
sterilized with alcohol. Alternatively, the diaphragm 112 could be
provided with a suitable removable sealing cover, to protect the
sterility of the outer diaphragm surface. The outer surface of the
needle holder, such as surface 212, is grasped by the person
assembling the unit, and the holder is slipped over the neck 101 of
the syringe 100. As it thus slides over the neck 101, point 206 of
the needle 201 pierces the rubber diaphragm 112 which closes the
syringe. The needle holder skirt 208 is pushed down tightly over
the syringe neck, a moderate amount of force being required to
yield lip 205, so that it tightly engages annular groove 114,
whereby a substantially rigid union is formed between the syringe
and the needle holder.
Because of the closed, pointed construction of the proximal end 206
of needle 201, the needle presses through the rubber diaphragm 112,
and cannot cut a core from the diaphragm, inasmuch as the lumen 211
of the needle 201 is closed at the pointed end 206. Thus, the
hypodermic needle construction of this invention readily avoids the
coring problem so frequently associated with the prior art
constructions. After pointed end 206 of needle 201 pierces
diaphragm 112, the apertured portion of the needle enters the
pierced diaphragm, to provide fluid communication between the
needle lumen 211 and the interior of syringe 100. As a result of
the tight fit between the needle holder skirt 208 and the annular
ring 113 surrounding the rigid neck 101 of the syringe, when the
needle, needle holder and syringe are in the position shown in FIG.
3, they form a substantially rigid unit for reliable utilization in
the injection of medicaments and other injectable fluids into human
beings and animals.
FIGS. 5 and 6 illustrate an alternative embodiment of the
non-coring needle of this invention, which can be used as the
proximal end construction for a non-coring needle mounted, for
example, in the needle holder illustrated in FIGS. 2 and 3. The
needle of FIGS. 5 and 6 constitutes a conventional hypodermic
needle 501 which is pointed at both ends, and the lumen of which is
in fluid communication with both pointed ends of the needle. A
substantially semi-circular metal piercing member 502 has a pointed
end extending about one-fourth inch beyond the proximal point of
needle 501. Piercing member 502 is preferably formed of rigid metal
or plastic and is rigidly joined to needle 501, as by a
high-stength adhesive or by welding. It is noted that the diameter
of semi-circular member 502 is slightly greater than the outer
diameter of the needle, so that the semi-circular cut which is made
in rubber diaphragm 112 when the needle passes through the rubber
diaphragm into the syringe is adequate to permit convenient,
substantially liquid-tight access of needle 501 into the syringe
interior. In the embodiment of FIGS. 5 and 6, the proximal end of
hypodermic needle 501 could be blunt, rather than pointed, if
desired.
FIGS. 7 and 8 illustrate an alternative non-coring needle
construction, similar to that shown in FIGS. 5 and 6, with the
exception that the piercing member is a planar member 702, which is
fastened along the side of needle 701. Planar member 702 extends
approximately one-fourth inch or more beyond the point of the
proximal end of needle 701, and provides a slit-type opening
through the rubber diaphragm 112, to permit non-coring passage of
the needle 701 through the diaphragm into fluid communication with
the syringe contents. In this embodiment, the proximal end of the
needle does not have to be pointed, and may be blunt, if
desired.
It will be appreciated that the needle and holder construction
illustrated may be modified for use with a variety of needle sizes,
and that these various needle sizes can be provided in a holder,
the proximal end dimensions of which may be consistent, so that a
single basic holder construction may be used to provide non-coring,
rigid, fluid-tight communication between a variety of sizes of
hypodermic needles, and a single size of hypodermic syringe or
ampule units.
It is also to be noted that, although a filled syringe is
illustrated in the drawings, it is equally possible and useful to
apply the article of this invention to use in an unfilled syringe
construction, in which the medicament or injectable fluid to be
administered is withdrawn from a bulk container.
Too, the principles of the invention may be used with ampules which
are designed for insertion in reusable metal hypodermic syringe
constructions, in which a pre-filled ampule or cartridge is
inserted in a reusable administration unit comprising an ampule
receptacle and an actuating plunger.
In the embodiment of the invention illustrated in FIGS. 9, 10, and
11, a hypodermic syringe and needle construction is provided which
has a substantial mechanical advantage to facilitate gradual,
non-pre-ejecting communication between a pre-filled syringe or
ampule and a hypodermic needle. Viewing FIG. 9, hypodermic needle
901 is shown as being of a type similar to that illustrated in
FIGS. 5 and 6, in that access through the syringe end closure is
provided by the use of a rigid, pointed, semi-circular piercing
member 941, having a point 940 for passing through the necked-down
portion 915 of a sealing rubber end closure member 911. The needle
901 is mounted in a needle holder 902, which comprises a solid body
having a narrow pendulous section to which the piercing member 941
is fastened, as by an adhesive, and which section 905 has an
opening for fluid communication with the proximal end 906 of
hypodermic needle 901. The outer surface of needle holder member
902 is provided with surface threads 920 which rotatably matingly
engage surface threads 921 on the inner face of sealing cap 913,
which cap 913 is tightly fitted on the lip 917 of disposable
syringe 910.
Syringe 910 is of a generally well-known construction, in that it
comprises a rigid, elongated, liquid-containing syringe body, one
end of which is closed by piston 912, and the other end of which is
closed by piercable rubber closure 911 having a central,
necked-down piercing section 915. The closure 911 has an outwardly
extending flange 916 which overlies lip 917 of the syringe.
The distal end of the syringe has an outwardly extending lip 917
which is connected to a narrow neck 918 between that flange and the
syringe body, and which seats the body of closure 911.
The sealing cap 913 has a downwardly extending skirt portion 919
terminating in an annular lip 914 which is seated below the lip 917
of the syringe in the narrow neck section 918. The sealing cap 913
has an inwardly extending threaded portion 922 which overlies the
rubber closure member 911, so that the rubber closure member 911 is
tightly, sealingly held by the sealing cap 913 between the lip 914
and the inwardly extending portion 922. Cap section 922 terminates
inwardly in internal threads 921 which matingly engage the threads
920 of needle holder 904. The sealing cap is fixed on the neck of
the syringe, and is not rotatable thereon.
Needle cover 903 overlies the distal end of needle 901 and the
needle holder section 904. The needle cap 903 is provided with a
downwardly extending projection 932 which engages in a detent 930
in the needle holder body, such that rotation of the needle cap 903
rotates the needle holder 902 through the engagement of projection
932, thereby gradually lowering the needle holder toward the
syringe. As lowering occurs, the piercing point 940 of piercing
member 941 engages the thin neck portion 915 of the syringe closure
911 and, as it rotates therein, cuts a flap 924 therefrom. FIG. 10
illustrates the final seated position of the needle holder 902
against the upper surface of the syringe closure member 911, so
that there is a tight, liquid seal between the needle holder and
the end closure, whereby liquid can flow through the aperture
created by flap 924, and through the opening in the proximal end
906 of needle 901.
The embodiment of FIG. 11 differs from that shown in FIGS. 9 and 10
only in the use of a ball 1101, mounted in an aperture 1115 in
rubber diaphragm 1102, to seal the aperture. The ball is made of
stainless steel or of plastic, and may be desired in certain
embodiments of the invention, to provide for thorough mixing of the
contents of the syringe prior to injection. Needle holder 1105 is
substantially the same as needle holder 902, with the exception
that the dependent projection 1104 of the needle holder is somewhat
longer in the embodiment of FIG. 11, than its counterpart 905 in
FIGS. 9 and 10, as the projection is used to dislodge the ball
1101. Also, the lower end of projection 1104 is formed with a
hemispherical recess 1107, to facilitate fluid communication
between the contents of the syringe and the needle 1106 in needle
holder 1105. In the use of this embodiment, needle cap 1103, which
lockingly engages needle holder 1105 by the action of projection
1132 in recess 1130 is rotated to lower the needle holder assembly,
dislodge ball 1101, and provide sealed fluid contact between the
syringe and the needle, in the manner shown in FIG. 10.
It may be desired to seal the needle holder and cap assembly of the
embodiment of FIGS. 9, 10 and 11, separately from the syringe or
ampule and its end closure assembly, in order to permit a wide
variety of needle sizes to be used with the syringe or ampule. In
that case, a suitable closure is provided for sealing cap 913, to
maintain the sterility of the upper surface of the syringe closure
911. Also, a suitable cap could be fabricated to cover the piercing
point 941 of the needle holder assembly, to prevent its
contamination. In that instance, a wide variety of needle sizes,
fabricated with holders 904 and caps 903 as parts of the same unit,
could be separately stored for use with a single size of syringe or
ampule and sealing cap, depending upon the size of the needle
needed for a particular purpose.
* * * * *