U.S. patent number 3,738,371 [Application Number 05/097,254] was granted by the patent office on 1973-06-12 for cardiac pacers with source condition-responsive rate.
This patent grant is currently assigned to ESB Incorporated. Invention is credited to Robert W. Johnson, William J. Raddi, Joseph W. Smithmyer.
United States Patent |
3,738,371 |
Raddi , et al. |
June 12, 1973 |
CARDIAC PACERS WITH SOURCE CONDITION-RESPONSIVE RATE
Abstract
In a pulse generating circuit, such as an implantable cardiac
pacer having parallel connected batteries as its power supply,
additional resistors are connected between the power supply and the
pulse generating circuit of the pacer and form a part of the pulse
generating circuit to indicate by a change in pulse rate when one
or more cells of the batteries of the power supply fail
prematurely.
Inventors: |
Raddi; William J.
(Philadelphia, PA), Johnson; Robert W. (Philadelphia,
PA), Smithmyer; Joseph W. (Philadelphia, PA) |
Assignee: |
ESB Incorporated (Philadelphia,
PA)
|
Family
ID: |
22262485 |
Appl.
No.: |
05/097,254 |
Filed: |
December 11, 1970 |
Current U.S.
Class: |
607/29; 307/48;
320/126; 307/53 |
Current CPC
Class: |
A61N
1/378 (20130101); A61N 1/362 (20130101); H03K
3/26 (20130101); H03K 3/30 (20130101) |
Current International
Class: |
A61N
1/362 (20060101); A61N 1/378 (20060101); A61N
1/372 (20060101); H03K 3/30 (20060101); H03K
3/00 (20060101); H03K 3/26 (20060101); A61n
001/36 () |
Field of
Search: |
;128/419P,419R,421,422
;320/29,40 ;307/48,53,55 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Kamm; William E.
Claims
We claim:
1. In an artificial cardiac pacer having
a. a power supply comprising a plurality of batteries connected in
parallel and wherein each battery is comprised of at least one
electrochemical cell and,
b. a pulse generating circuit operatively connected across the
power supply to translate the power supplied by the power supply
into electrical impulses, and being operable to provide said
electrical impulses to electrodes operatively connected to a
patient's heart, the improvement comprising, means for causing the
pulse generating circuit to generate pulses at a first frequency
and, upon failure of any of the batteries of the power supply, to
generate pulses at a second frequency different from the first
frequency; the power supply being further characterized as having
at least two parallel branches, each parallel branch of the power
supply having disposed therein at least one electrochemical cell,
and at least one semiconductor means operatively connected with the
electrochemical cell, the semiconductor means in each parallel
branch being arranged to permit current flow therethrough from the
electrochemical cell connected therewith to the pulse generating
circuit and to prevent current flow therethrough from the
electrochemical cells in other parallel branches of the power
supply, said means for causing the pulse generating circuit to
generate pulses at a first frequency and, upon failure of any of
the batteries of the power supply, to generate pulses at a second
frequency different from the first frequency including at least a
pair of resistors, each resistor being operatively connected to the
pulse generating circuit and forming a part thereof.
2. In an artificial cardiac pacer as set forth in claim 1 wherein
each resistor is operatively connected to a parallel branch of the
power supply at a point between the electrochemical cell and the
semiconductor means disposed in each parallel branch of the power
supply.
3. A body implantable artificial cardiac pacer comprising
a. a body compatible implantable insulating encapsulation
container,
b. a power supply in the encapsulation container comprising at
least two parallel branches, each parallel branch of the power
supply having disposed therein at least one electrochemical cell
and at least one semiconductor means in series circuit with the
electrochemical cell,
c. a semiconductor pulse generating circuit in the encapsulation
container operatively connected across the power supply to
translate the power supplied by the power supply into electrical
impulses and being operable to provide said electrical impulses to
electrodes operatively connected to a patient's heart, the
semiconductor means in each parallel branch being arranged to
permit current flow therethrough from the electrochemical cell in
series circuit therewith to the pulse generating circuit and to
prevent current flow therethrough from the electrochemical cells in
other parallel branches of the power supply, and
d. timing means in the encapsulation container operatively
connected to the power supply and forming a part of the pulse
generating circuit to govern the pulse repetition rate of the
pulses generated by the pulse generating circuit and, upon failure
of any of the electrochemical cells of the power supply to vary the
pulse repetition rate of the pulse generating circuit; said timing
means including at least a pair of resistors, each of the resistors
being operatively connected to a different parallel branch of the
power supply at a point between the electrochemical cell and the
semiconductor means disposed in each parallel branch of the power
supply.
4. In an artificial cardiac pacer having
a. a power supply comprising a plurality of batteries connected in
parallel and wherein each battery is comprised of at least one
electrochemical cell and,
b. a pulse generating circuit operatively connected across the
power supply to translate the power supplied by the power supply
into electrical impulses, and being operable to provide said
electrical impulses to electrodes operatively connected to a
patient's heart, the improvement comprising, means including
circuit means operatively connected to each of the batteries and to
the pulse generating circuit and forming a part of the pulse
generating circuit for causing the pulse generating circuit to
generate pulses at a first frequency and, upon failure of any of
the batteries of the power supply, to generate pulses at a second
frequency different from the first frequency.
5. A body implantable artificial cardiac pacer comprising
a. a body compatible implantable insulating encapsulation
container,
b. a power supply in the encapsulation container comprising at
least two parallel branches, each parallel branch of the power
supply having disposed therein at least one electrochemical cell
and at least one semiconductor means in series circuit with the
electrochemical cell,
c. a semiconductor pulse generating circuit in the encapsulation
container operatively connected across the power supply to
translate the power supplied by the power supply into electrical
impulses and being operable to provide said electrical impulses to
electrodes operatively connected to a patient'heart, the
semiconductor means in each parallel branch being arranged to
permit current flow therethrough from the electrochemical cell in
series circuit therewith to the pulse generating circuit and to
prevent current flow therethrough from the electrochemical cells in
other parallel branches of the power supply, and
d. timing means including means operatively connected to each
branch of the power supply and to the pulse generating circuit and
forming a part of the pulse generating circuit in the encapsulation
container for governing the pulse repetition rate of the pulses
generated by the pulse generating circuit and, upon failure of any
of the electrochemical cells of the power supply to vary the pulse
repetition rate of the pulse generating circuit.
6. In an artificial cardiac pacer having
a. a power supply comprising a plurality of batteries connected in
parallel and wherein each battery has substantially the same
terminal voltage and is comprised of at least one electrochemical
cell and,
b. a pulse generating circuit operatively connected across the
power supply to translate the power supplied by the power supply
into electrical impulses, and being operable to provide said
electrical impulses to electrodes operatively connected to a
patient's heart, the improvement comprising, means for causing the
pulse generating circuit to generate pulses at a first frequency
and, upon failure of any of the batteries of the power supply, to
generate pulses at a second frequency different from the first
frequency.
7. A body implantable artificial cardiac pacer comprising
a. a body compatible implantable insulating encapsulation
container,
b. a power supply in the encapsulation container comprising at
least two parallel branches, each parallel branch of the power
supply having disposed therein at least one electrochemical cell
and at least one semiconductor means in series circuit with the
electrochemical cell, each electrochemical cell having
substantially the same terminal voltage,
c. a semiconductor pulse generating circuit in the encapsulation
container operatively connected across the power supply to
translate the power supplied by the power supply into electrical
impulses and being operable to provide said electrical impulses to
electrodes operatively connected to a patient's heart, the
semiconductor means in each parallel branch being arranged to
permit current flow therethrough from the electrochemical cell in
series circuit therewith to the pulse generating circuit and to
prevent current flow therethrough from the electrochemical cells in
other parallel branches of the power supply, and
d. timing means in the encapsulation container operatively
connected to the power supply and forming a part of the pulse
generating circuit to govern the pulse repetition rate of the
pulses generated by the pulse generating circuit and, upon failure
of any of the electrochemical cells of the power supply to vary the
pulse repetition rate of the pulse generating circuit.
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to pulse generating devices, and more
particularly to pulse generating devices where it is desired to
determine the state of the batteries of the power supply of the
device from the rate of operation of the device. The invention will
here be described in most detail in association with battery
powered electronic organ stimulation device or cardiac pacer since
the apparatus according to the invention has been particularly
developed for use with such pacers, however, the apparatus may be
used in other battery powered pulse generating devices. It might
perhaps be used in conjunction with stimulators for the brain,
bladder and other organs as well, and with pacers other than the
type hereinafter described without departing from the scope of the
invention.
2. Description of the Prior Art
It may be explained that cardiac pacing has become the standard
mode of therapy for heart block and its complications. Briefly,
heart block is the reduction or complete lack of coordination in
the beating of the atria and ventricles of the heart. In the human
body, blood is pumped primarily by the contractions of the
ventricles of the heart which are triggered by natural electrical
signals originating in the atrium of the heart. Physiological
conditions which weaken or eliminate these natural signals result
in a lack of coordination between the atria and ventricles and
consequently, the natural pumping action of the heart is affected,
at times resulting in death.
In order to overcome this condition, cardiac pacer have been
developed to artifically stimulate the contraction of the
ventricles with electrical pulses generated by the pacer. These
pacers are implanted in the body of a patient along with batteries
for powering the pacer and electrical leads attached to the
heart.
At present, most commercial cardiac pacers utilize a set of five or
six primary mercury cells connected in series as their power
source. With such pacers, a change in pace or pulse rate reflects a
change in battery voltage, for example, a rate decrease of several
pulses per minute will indicate a drop in battery voltage,
suggesting pacer replacement.
Accordingly, a pulse rate decrease in pacers that use five or six
cells connected in series is an indication of battery exhaustion. A
disadvantage of such a configuration is that should an individual
cell of the power source fail prematurely, it is possible for the
failed cell to be driven by the other cells of the battery into
potential reversal and thus generate internal gas pressure from the
electrolysis of the electrolyte in the failed cell. Furthermore,
performance and reliability of such pacers are also affected as a
result of reduced battery voltage. Consequently, when one or two
cells fail in a conventional pacer utilizing a power supply of five
or six series connected cells, future operation of the pacer
becomes doubtful and the unit is preferably replaced. Pacer
longevity, therefore, is not necessarily determined by the average
cell life but instead it can and often times is limited by the
performance of the weakest cell in the battery forming the power
supply of the pacer.
Because battery failure or premature battery exhaustion has been
determined to be the principal cause of failure in cardiac pacers,
it has become desirable to use several batteries connected in a
parallel redundant configuration as the pacer power source.
The parallel connection of the cells or batteries is generally made
through diodes or transistors such that when a cell or battery in
one parallel branch fails prematurely the diode associated with
that battery reverse biases thereby automatically disconnecting
that battery from the load. Thus, the voltage of the power supply
supplying the pacer remains relatively unchanged and the operation
of the pacer remains virtually unchanged. As with the type pacers
having a single battery comprised of series connected primary cells
as the power source, pacers having parallel connected batteries as
a power source will, near the end of life of the batteries of the
power source, manifest a change in operation due to lower voltage
which is reflected in a change in the pulse rate.
There is, however, a major disadvantage of using redundant
batteries in that when one of the batteries or cells in one of the
parallel branches prematurely fails there is no outward indication
of such failure. In pacers having a battery comprised of series
connected cells, as set forth above, the usual indication of
battery failure is reduced pulse rate which, generally is
proportional to battery terminal voltage. Consequently, with a
three-cell redundant system as for example, the pacer could be
operating on one third power very shortly after implant if cells of
two parallel branches fail, with no outward indication to either
patient or attending physician. The danger of this situation is
obvious since it is assumed that after implantation the pacer will
operate safely for a predicted period of time when, in fact, in
only one third or less of that time the pacer will certainly
fail.
SUMMARY OF THE INVENTION
Briefly, the invention provides apparatus that will indicate when
one or more of the electro-chemical cells powering a pulse
generating devices fails.
In accordance with the invention, a pulse generating device is
provided having a power supply comprising a plurality of batteries
connected in parallel wherein each battery is comprised of at least
one electrochemical cell. A pulse generating circuit is provided
operatively connected across the power supply to translate the
power supplied by the power supply into electrical impulses. Means
are provided adapting the pulse generating circuit to generate
pulses at a first frequency and, upon failure of at least one of
the electrochemical cells of the power supply, to generate pulses
at a second frequency different from the first frequency.
The apparatus, in accordance with the invention, is essentially
free of the defects of the prior art devices having parallel
connected batteries in that it provides an outward indication of
cell or battery failure in the power supply when such failure
occurs. The apparatus of the invention is an improvement over
devices having five or six series connected cells as a power supply
in that if a cell or battery of the power supply of the apparatus
of the invention fails, there is an ample reserve of energy to
permit continued operation of the pacer.
A more complete understanding of the invention will become apparent
from the following description, taken in conjunction with the
accompanying drawings which form a part of this specification.
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a schematic diagram of a prior art pacer having a power
supply comprising a plurality of cells connected in parallel;
FIG. 2 is a schematic diagram of a pacer is accordance with the
invention;
FIG. 3 is a bar graph illustrating the effect of cell failure in
the pacer of FIG. 2; and
FIG. 4 is a perspective view of the encapsulation container in
which the circuit of FIG. 2 is housed.
DESCRIPTION OF THE PREFERRED EMBODIMENT
The invention may be best understood from the following detailed
analysis of a prior art pacer shown in FIG. 1 and the pacer of the
invention shown in FIG. 2. In the drawings, like reference
characters refer to like parts throughout the several drawings.
Referring now to FIG. 1, the numeral 10 generally designates a
heart stimulator or cardiac pacer which is adapted to provide
electrical impulses of predetermined duration and rate for
application to the human heart. The pacer 10 includes a power
supply 12 comprising three parallel branches 14, 16 and 18 and the
pacer circuitry shown at 19. Each branch of the power supply
comprises a battery preferably consisting of two electrochemical
primary cells connected in series. Each cell is preferably a 1
ampere-hour, medically certified cell having a terminal voltage of
approximately 1.38 volts at 25.degree. C. Other suitable batteries
may, of course, be utilized. The power supply described stores
sufficient energy to operate the pacer 10 for a projected 5 year
life.
Each parallel branch of the power supply includes a diode 20.
Preferably, the diodes 20 are germanium diodes to minimize the
forward voltage drop across them. The diodes 20 effect the parallel
connection of the batteries such that if any one or two of the
three batteries should fall, the voltage at the cathode side of the
diodes would be relatively unchanged since the particular diode or
diodes connected to the failed battery or batteries would reverse
bias thereby disconnecting the defective battery from the power
supply. Consequently, the operation of the pacer will be
essentially unchanged if one or two of the three batteries of the
power supply fails. This is because the pacer circuitry 19 requires
very low currents in terms of the capacity of the batteries of the
power supply and because each of the batteries of the power supply
has a very low internal resistance.
The pacer circuitry 19 includes the pulse generating circuit, shown
generally at 22. The pulse generating circuit 22 is connected
across the power supply 12 to translate the power supplied by the
power supply into electrical impulses.
In considering the operation of the pulse generating circuit 22,
the transistors 25 and 26 are connected as a two stage rate
adjustable complementary astable blocking oscillator which produces
pulses of fixed duration, as for example, a 1ms pulse approximately
once every 833ms. The pulse rate of the oscillator is proportional
to the voltage of the power supply 12 and this feature provides an
indication of battery voltage which can be used to predict normal
pacer failure or normal battery exhaustion. The transistor 25 is of
the NPN type and the transistor 26 is the PNP type. Both
transistors have the usual emitter, collector and base electrodes.
When the power supply charges capacitor 28 via resistors 30 and 32
sufficiently to forward bias the emitter base junction of the
transistor 25, this transistor conducts. The resistor 31 is
connected between the emitter of transistor 25 and point 35. Since
the collector of transistor 25 is connected to the base of
transistor 26, it in turn causes transistor 26 to conduct. As
transistor 26 conducts, current flows through the primary winding
33 of transformer 34 which induces a voltage in the secondary
winding 36 of transformer 34. The secondary winding is so connected
that the induced voltage further increases the base current
supplied to transistor 25. This regenerative action causes a rapid
pulse rate which continues until both transistors 25 and 26 are in
saturation. Transistors 25 and 26 remain saturated for the duration
of the pulse during which capacitor 28 is partially discharged. The
width of the pulse thus produced is controlled primarily by the
inductance of the transformer 34 and the capacitance of capacitor
28 with little dependence upon supply voltage.
Continuing with the operation of the pulse producing circuit 22 of
FIG. 1, when the induced voltage in the secondary winding 36 begins
to diminish, the current flowing into the base of transistor 25
also diminishes which in turn reduces the base current of
transistor 26. As transistor 26 turns off, the current in primary
winding 33 decreases which further reduces the induced secondary
voltage of winding 36. This latter regenerative action rapidly
switches transistors 25, 26 from saturation to cut-off and the
pulse terminates. The voltage which was developed across capacitor
28 during the pulse now reverse biases the emitter-base junction of
transistor 25 to the voltage level at which the capacitor 28 was
partially discharged. The cycle repeats with the charging of
capacitor 28 through resistors 30 and 32.
Continuing with the operation of the pacer 10 of FIG. 1, the pulse
appearing across the primary winding 33 of transformer 34 is
coupled through resistor 40 to the base of transistor 42.
Transistor 42 acts as a switch which connects the voltage of the
power supply, less the voltage drop across the diodes 20, via
capacitor 43 to a simulated heart load, shown here as resistor 44,
which is connected across the output terminals. The resistor 46
discharges capacitor 43 between pulses.
The pacer circuit of FIG. 1 is characterized by the fact that the
pulse repetition rate of the pulse generating circuit 22 is
determined by the rate at which capacitor 28 charges to the base
potential at which transistor 25 will conduct current. The current
that charges capacitor 28 is determined by the resistors 30 and 32.
Accordingly, the values of the resistors 30, 32 and the value of
the capacitor 28 may be considered as a RC timing means or circuit
which determines the length of time between pulses, i.e., the pulse
repetition rate. As described above, as the voltage of the power
supply 12 decreases, the pulse rate will also decrease. The
batteries of the power supply 12, however, are of the type that
maintain a substantially constant voltage throughout their lives
and then suddenly run down. Therefore, a change or decrease in
pulse rate is normally not had with the pacer of FIG. 1 unless the
batteries of the power supply are near the end of their useful
lives. The pacer of FIG. 1, therefore, has an inherent disadvantage
in that there will be no outward indication, i.e., decrease in
pulse rate, when one or two of the batteries of the power supply
fails since the terminal voltage of the power supply is virtually
unchanged due to the redundant configuration of the batteries of
the power supply. Consequently, pulse rate proportional to voltage,
as provided by the circuit 22 of FIG. 1, is only useful when all
three batteries of the power supply fail simultaneously, generally,
near the end of the expected life of the batteries. If one or two
of the batteries of the power supply fail shortly after
implantation of the pacer, the pacer could be operating on
one-third original capacity and there would be no way of
determining this fact with the pacer of FIG. 1.
In order to have an outward indication of the premature failure of
one or two of the batteries of the power supply, the pacer of FIG.
1 was modified as shown in FIG. 2.
Comparing FIG. 1 and FIG. 2, it will be seen that they differ in
that FIG. 2 has included therein three resistors 50, 52, and 54.
Each of the resistors is connected at one end to the junction point
56 which in turn is connected to the junction point 58 between
resistors 30 and 32. The opposite end of each resistor 50, 52 and
54 is connected to one of the batteries of the power supply 12; the
resistor 50 being connected to the point 60 between the battery of
and the diode 20 of parallel branch 18; the resistor 52 being
connected to the point 62 between the battery and the diode 20 of
parallel branch 16; and the resistor 54 being connected to the
point 64 between the battery and the diode 20 of parallel branch
14.
It can be seen that portions of the current that charge capacitor
28 in FIG. 2 are provided through the resistors 50, 52 and 54 in
addition to the current provided through resistors 30 and 32, the
latter resistors being the only ones in the charging path between
the power supply 12 and the capacitor 28 in the circuit of FIG. 1.
The resistors 50, 52 and 54, therefore, form part of the RC timing
circuit of pulse generating circuit 22 of FIG. 2.
In the pacer circuit of FIG. 2, should a battery in one parallel
branch fail prematurely, the portion of capacitor current provided
by the specific resistor 50, 52, or 54 associated with the failed
battery will be reduced which in turn will reduce the pulse rate of
the pacer. The modified pacer shown in FIG. 2 will, therefore,
provide an outward indication of battery failure reflected in a
reduction in pulse rate. This indication can be used to inform the
patient or physician of impending pacer failure.
FIG. 3 is a bar graph illustrating the effect of catastrophic or
irregular cell failure in the pacer of FIG. 2. The failure mode in
each situation was simulated by replacing a cell of the various
batteries of the power supply 12 with a short circuit. The data
given for three and four cells failed was obtained with one of the
2-cell batteries in one parallel branch intact.
FIG. 4 shows the circuit of FIG. 2 in an encapsulation container
designated by the reference numeral 70. The components of the
circuit are assembled on a circuit board, not shown, and
encapsulated in a suitable epoxy resin or other suitable body
implantable material. The container 70 may be surgically implanted
in a body with the insulated unipolar transvenous catheter 72
connected to the heart at the desired location, preferably, the
endocardium. A large corrosive resistant metal anode plate
functions as the catheter antipode and is physically located on the
outer surface of the encapsulation container as is shown at 77.
Saline body fluids complete the current path between catheter
electrode 78 and the anode plate 77 when the pacer is implanted in
the body.
In a practical embodiment of this invention, the components of the
described apparatus can have the following values.
Resistance (ohms) 50 10,000K 52 10,000K 54 10,000K 30 680K 32 680K
33 1K 46 47K 40 4.7K Capacitors (.mu.F) 28 2.3 43 15 Transistors:
25 2N718A 26 2N3217 42 2N2219A Transformer: 34 United Transformer
Corp. No. BIT - 250 - 48 Diodes: 20 1N3287
while there has been described and pointed out the fundamental
novel features of the invention as applied to a preferred
embodiment, it will be understood that various omissions and
substitutions and changes in the form and details of the device
illustrated and its operation may be made by those skilled in the
art, without departing from the spirit of the invention. It is the
intention, therefore, to be limited only as indicated by the scope
of the following claims.
* * * * *