U.S. patent number 3,734,091 [Application Number 05/155,547] was granted by the patent office on 1973-05-22 for oxygen control system with blood oxygen saturation sensing means and method for closed system breathing.
This patent grant is currently assigned to Airco, Inc.. Invention is credited to Ronald H. Taplin.
United States Patent |
3,734,091 |
Taplin |
May 22, 1973 |
OXYGEN CONTROL SYSTEM WITH BLOOD OXYGEN SATURATION SENSING MEANS
AND METHOD FOR CLOSED SYSTEM BREATHING
Abstract
The blood circulating in the body of the subject, e.g. in the
ear pinna, is tested at suitable time intervals to detect
supersaturation of oxygen, using an optical oximeter and a
temporary oxygen-deficient (anoxic) breathing mixture in
conjunction with a timing device to develop a signal which varies
inversely with the time required for the anoxic mixture to bring
the oxygen level in the blood down to saturation level, which
signal is used to control the duty cycle of a valve in the line
supplying oxygen to the user's breathing bag, so that between tests
the user is provided with oxygen at a rate responsive to his
breathing requirements to maintain his system close to 100 percent
saturation in oxygen; an over-riding control being exerted by the
oximeter to increase the flow rate of oxygen to the user
immediately whenever the oximeter detects an oxygen level below
saturation; the anoxic mixture being provided by temporarily
reducing the flow rate of oxygen through the valve to a suitable
low value.
Inventors: |
Taplin; Ronald H. (Shirley,
EN) |
Assignee: |
Airco, Inc. (New York,
NY)
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Family
ID: |
22555871 |
Appl.
No.: |
05/155,547 |
Filed: |
June 22, 1971 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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65268 |
Aug 19, 1970 |
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708054 |
Feb 26, 1968 |
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Current U.S.
Class: |
128/204.23;
600/323 |
Current CPC
Class: |
A61M
16/10 (20130101); A61B 5/0833 (20130101); A61M
2230/005 (20130101); A61M 2230/205 (20130101); A61M
2230/205 (20130101) |
Current International
Class: |
A61B
5/083 (20060101); A61B 5/08 (20060101); A61B
5/15 (20060101); A61M 16/10 (20060101); A61b
005/00 () |
Field of
Search: |
;128/2L,2R,142,191,202 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Kamm; William E.
Parent Case Text
BACKGROUND OF THE INVENTION
This application is a Continuation-in-Part of an application Ser.
No. 65,268 , filed on Aug. 19, 1970, now abandoned. This last
mentioned application was a Streamlined Continuation of application
Ser. No. 708,054, filed on Feb. 26, 1968, now abandoned.
Claims
I claim:
1. In apparatus for controlling the oxygen concentration in a
breathing mixture for supplying a user, in combination, means to
measure supersaturation of oxygen in the blood stream of the user
by establishing the time required for an anoxic mixture to reduce
oxygen content at said blood stream below saturation, means
providing a control signal determined by said time, and means
responsive to said control signal to adjust the oxygen
concentration in said breathing mixture in relation to the measured
degree of supersaturation.
2. Apparatus for measuring the degree of oxygen supersaturation in
the blood stream, comprising, in combination, an oximeter of a type
that can detect oxygen concentration up to 100 percent of
saturation, means for temporarily supplying to the lungs a
breathing mixture having a constant degree of oxygen deficiency,
means employing said oximeter to continuously monitor the state of
the blood and to generate a signal when the blood stream is reduced
from whatever degree of supersaturation existed when the
oxygen-deficient mixture was first supplied to a condition of
substantially 100 percent saturation, and means to measure the time
elapsed from the time at which the oxygen-deficient mixture was
first supplied until the 100 percent saturation signal is generated
by the oximeter, whereby the elapsed time is a measure of the
original degree of supersaturation of the blood stream.
3. Apparatus in accordance with claim 2, together with means
responsive to the length of said elapsed time for controlling the
oxygen concentration of a breathing mixture normally supplied to
the user in accordance with the measured degree of
supersaturation.
4. A system for regulating the rate of oxygen supply for closed
system breathing in such manner as to avoid either under or over
saturation of the user's blood with oxygen, comprising in
combination, an optical oximeter arranged for continuously
monitoring the user's blood, said oximeter being capable of
detecting under-saturation of oxygen in the blood of the user,
means for periodically reducing the supply rate of oxygen to the
user to a constant oxygen-deficient rate, means for counting a
succession of time intervals of substantially equal duration, means
to start a count in said counting means coincidently with the
beginning of the oxygen-deficient supply to the user, means to
generate a signal when the oximeter first detects an oxygen
concentration less than 100 percent in the blood of the user, means
to use said signal to increase the supply rate of oxygen to a
non-deficient value and to stop the said count, and means to use
the magnitude of said count to regulate the said non-deficient rate
of oxygen supply to the user in response to the measured degree of
supersaturation.
5. A system in accordance with claim 4, together with means
operative at any time that the oximeter detects a predetermined
oxygen concentration less than 100 percent of saturation to
generate a second signal, and means to utilize said second signal
to immediately increase the rate of oxygen supply to the user to
relieve the detected oxygen deficiency.
6. A system in accordance with claim 4, together with means for
adjusting the time period between successive operations of the said
oxygen supply rate reducing means.
7. A system for regulating the rate of oxygen supply for closed
system breathing in such manner as to avoid either under or over
saturation of the user's blood with oxygen, comprising in
combination, first regulatory means designed to determine a
relatively low, constant rate of oxygen supply useful for gradually
relieving a condition of supersaturation of oxygen in the user's
blood, second regulatory means arranged to determine a variable
rate of oxygen supply in accordance with the user's demand for
oxygen from time to time, a third regulatory means designed to
determine a constant rate of oxygen supply greater in magnitude
than any rate determined by either said first or said second
regulatory means for rapidly making up any oxygen deficiency in the
user's blood, an optical oximeter arranged to continuously monitor
the user's blood, time interval measuring means, sample interval
timing means for initiating a measurement of degree of
supersaturation of oxygen in the blood, means actuated by said
sample interval timing means to energize said first regulatory
means, and to start a time measurement in said time interval
measuring means, means operable by said oximeter upon detection of
less than 100 percent oxygen saturation in the user's blood to
terminate a time interval measurement by said time interval
measuring means and to disable said first regulatory means, means
controlled by said time interval measuring means for adjusting the
said second regulatory means, to determine an oxygen supply rate
inversely proportional to the time interval so measured and to
energize said second regulatory means, and means operable by said
oximeter upon detection of an oxygen deficiency in the user's blood
to enable said third regulatory means while at the same disabling
both said first and second regulatory means, to relieve said oxygen
deficiency at any time regardless of the operation of the remainder
of the system.
8. The method of controlling the oxygen concentration in a
breathing mixture for supplying a user, comprising the steps of
measuring supersaturation of oxygen in the blood stream of the user
by establishing the time required for an anoxic mixture to reduce
oxygen content at said blood stream below saturation, generating a
control signal determined by said time, and using the said control
signal to adjust the oxygen concentration in the said breathing
mixture in relation to the degree of supersaturation measured.
9. The method of measuring the degree of oxygen supersaturation in
the blood stream with the aid of an oximeter of a type that can
detect oxygen concentration up to 100 percent of saturation, which
method comprises the steps of temporarily supplying to the lungs a
breathing mixture having a constant oxygen deficiency, using the
oximeter to continuously monitor the state of the blood and to give
a signal when the blood stream is reduced from whatever degree of
supersaturation existed when the oxygen-deficient mixture was first
supplied to a condition of substantially 100 percent saturation,
and measuring the time elapsed from the time at which the
oxygen-deficient mixture was first supplied until the 100 percent
saturation signal is generated by the oximeter, whereby the elapsed
time is a measure of the original degree of supersaturation of the
blood stream.
10. The method in accordance with claim 9, together with the
further step of generating a control signal inversely proportional
to the said elapsed time, and utilizing the said control signal for
decreasing the supply rate of oxygen to the lungs in proportion to
the measured degree of supersaturation.
Description
FIELD OF THE INVENTION
The invention relates to systems for supplying a suitable breathing
mixture, with provision for automatic control of the rate of flow
of oxygen in order to supply oxygen to the user in accordance with
his needs from time to time, as while working under water, or while
being operated upon, etc.
DESCRIPTION OF THE PRIOR ART
In the past, an optical oximeter has been used to monitor the
oxygen level in the blood to produce an electric signal that is
used to regulate the supply of oxygen to breathing apparatus
carried by the user, e.g., a deep sea diver, increasing the oxygen
supply when the oxygen level falls and decreasing the oxygen supply
when the oxygen level rises. The object is to maintain the oxygen
level in the blood of the user substantially at saturation value at
all times. Light transmitted by the apparatus through blood varies
in intensity and color as the oxygen level in the blood varies due
to changes in the red corpuscles as they absorb oxygen, thus making
it possible to determine quantitatively the oxygen level of the
blood. However, a difficulty arises, in that when the blood becomes
saturated with oxygen, supersaturation will occur if more oxygen is
supplied to the blood stream, the excess oxygen being absorbed in
the blood plasma or in adjacent tissues instead of in the red
corpuscles, which latter can absorb no more. When this occurs,
there is no further change in the color or intensity of the
transmitted light, with the result that the oximeter is unable to
measure any degree of supersaturation of oxygen in the system of
the user. As it is known that supersaturation with oxygen is an
undesirable condition for the user and, if carried to excess, can
be dangerous to health, it is desirable that the breathing system
be enabled to respond not only to a condition of oxygen deficiency,
but also to a condition of supersaturation.
SUMMARY OF THE INVENTION
The invention provides a method and apparatus for using an optical
oximeter to monitor the blood of the user to detect supersaturation
of oxygen in the system of the user when this condition occurs, in
order to generate a signal proportional to the degree of such
supersaturation, which signal is used to reduce the oxygen supply
as required to relieve the condition of supersaturation and thus
maintain the system of the user substantially at 100 percent oxygen
saturation. Supersaturation is measured by periodically putting the
user on an anoxic breathing mixture of constant degree of oxygen
deficiency which gradually lowers the oxygen level in the user's
system. Return to a level just below saturation is detected by the
oximeter after a certain time interval that is proportional to the
degree of supersaturation that was present. A signal inversely
proportional to this time interval is used to regulate the oxygen
supply substantially to the 100 percent oxygen saturation level. An
over-riding control is provided so that the anoxic breathing
mixture will not be given to the user at any time when the blood is
deficient in oxygen, but instead the rate of oxygen flow will
immediately be increased.
BRIEF DESCRIPTION OF THE DRAWING
The single FIGURE is a block-type schematic circuit diagram of the
preferred embodiment of the invention.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring to the drawing, 20 is an intermittently operable on-off
valve connecting an oxygen supply to a breathing bag, under the
control of an optical oximeter 22 actuated by changes in color and
intensity of blood circulating in the body of the user, e.g. in the
ear pinna. The valve 20 is opened and closed by electrical pulses
from a controlled variable-width pulse generator 24 acting upon a
solenoid valve-actuating device represented schematically by an
inductance coil 26. The valve is open during each pulse and closed
between pulses. A suitable oximeter for use herein and an improved
earpiece therefor are shown and described in U. S. Pat. No.
2,790,438, issued Apr. 30, 1957 jointly to this applicant and to
William Paul. In general, the device 22 may be any device capable
of measuring the degree of oxygenation of the blood of the user
from an oxygen-deficient level up to but not over, 100 percent of
saturation in the blood corpuscles, at which latter level
detectable changes in the blood corpuscles cease while saturation
of the blood system as a whole can increase beyond 100 percent.
The time duration of the pulse, termed the pulse width, is
determined by the time required for an adjustable time-variable
one-shot multivibrator 28 to return to its stable state after being
put into an unstable state by a pulse from a valve cycle rate
adjuster 30. The time required by the multivibrator 28 to return to
its stable state is in turn determined by a direct current signal,
termed a d.c. level, applied to a control electrode of the
multivibrator. The lower the d.c. level, the shorter the time
interval determined by the multivibrator and hence the less the
pulse width of the pulse applied to the solenoid 26 by the
generator 24 and the shorter the open time of the valve 20.
Similarly, the higher the d.c. level, the longer the open time of
the valve 20. The total time interval or cycle time comprising a
pulse and the space following the pulse is adjustable by means of
the valve cycle time adjuster 30, which is arranged to deliver a
pulse to the multivibrator 28 at adjustable regular intervals
longer than the maximum time interval determined by the
multivibrator. Thus, the frequency at which the valve 20 operates,
as well as the duty cycle of the operation of the valve can be
adjusted over suitable ranges. The valve 20 will ordinarily open
and close every 2 to 5 seconds, although other frequencies of
operation may be used. As the user breathes from a breathing bag in
the conventional manner, the periodic closing of the valve 20 at
these rates does not interfere with breathing and is a part of
standard practice. The valve 20 performs the function of a make-up
for keeping the breathing bag up pg,5 to suitable pressure at all
times.
Three separate sources of d.c. level 31, 32 and 33 are provided for
varying the time interval determined by the multi-vibrator 28. The
source 31 has the lowest level, for establishing an anoxic mixture
by cutting down the oxygen flow rate through the valve 20 to a
suitable low value. This rate is adjustable by a potentiometer or
other suitable device shown as a d.c. level adjuster 34. The source
32 has a range of intermediate levels and the level provided at any
given time is varied in accordance with measurements made upon the
degree of supersaturation in the user's blood obtained with the aid
of the oximeter 22. The source 33 has the highest level and comes
into play whenever a condition below a minimum safe percent
saturation, e.g. 97 percent, is detected by the oximeter 22. The
oxygen flow rate to the breathing bag at any given time depends
upon which of the three sources 31, 32, 33 is at that time
controlling the multivibrator 28. When the source 33 is in control,
the valve 20 will have a duty cycle such that the valve is open
most of the time, e.g., 19 twentieths of the time. Consequently,
the oxygen deficiency alarm 33 is effective to increase the oxygen
pressure in the breathing bag at a very rapid rate, thus assuring
protection of the user from serious oxygen deficiency as detected
by the oximeter 22.
A measurement to determine supersaturation of oxygen in the user's
blood is initiated at time intervals of about one to five minutes,
under the control of a sample interval timer 44, the length of the
interval being adjustable by any suitable means, shown as a sample
rate adjuster 46. The timer 44 sends start signals, (1) to a
counter-clear device 48 connected to a counter 50 to re-set the
counter to zero, (2) to operate a switch 52 to immediately admit a
train of regularly spaced pulses from a counter time base pulse
generator 54 to the counter 50 through the switch 52 to make a
count, and (3) to turn on a flip-flop 56 by applying a signal to a
conductor 58 causing the flip-flop to generate a high level or ON
output signal on a conductor 60 connected to one input terminal of
the linear gate 36, and to generate a low level or OFF output
signal on a conductor 62 connected to one input terminal of the
linear gate 38. The presence of the ON signal on the conductor 60
permits the d.c. level from device 31, which is always present on a
conductor 64 connected to the second input terminal of the linear
gate 36 to pass through that circuit to the signal mixer amplifier
40 with the result that the valve 20 is operated in a low duty
cycle suitable to deliver the desired anoxic mixture for the
saturation measurement. Linear gates of the type shown in schematic
form are well known in the art. Such gates can be designed to
transmit analog information and can be opened or closed by a
controlling voltage.
The anoxic mixture is supplied to the user and, if the user's blood
is supersaturated, the counter 50 counts until the oxygen level in
the user's blood has fallen from the degree of supersaturation
existing at the start of the count to approximately 100 percent
saturation, at which time the oximeter 22 detects a lack of 100
percent saturation and sends a signal from a 100 percent saturation
detection signal means 66 (1) to the switch 52 over a conductor 67
to stop entry of pulses into the counter 50 through the switch 52,
thereby stopping the count, and (2) over a conductor 68 to reverse
the flip-flop 56, putting a low level or OFF signal on the
conductor 60 and a high level or ON signal on the conductor 62. The
effect of reversing the flip-flop 56 is to disable the linear gate
36 and enable the linear gate 38. The stopped count remains stored
in the counter 50 until the next time the counter-clear 48 is
actuated. A digital to analog converter 70 is provided which at all
times converts the count to a d.c. level which increases with the
count. An inverter 72 is provided to give a d.c. level which
decreases as the count increases, so as to provide for decreasing
the flow rate of oxygen to correspond with an increase in the
degree of supersaturation found in the test. The inverter 72
controls the d.c. level in the device 32. The converter 70 and
inverter 72 are so adjusted that a zero count, indicating an
absence of supersaturation will provide the proper d.c. level in
device 32 to set the valve 20 for a flow rate suitable to just
maintain 100 percent saturation.
The linear gate 38 remains in the enabled condition, transmitting
the d.c. level from the device 32 to the signal mixer amplifier 40
continuously until the next operation of the sample interval timer
44 initiating a new measurement of the blood condition, the result
of which measurement may be to increase the rate of oxygen supply,
or to decrease the supply, or to continue the previous rate
according to the user's blood condition. Diodes 41 and 42 are
positioned so as to direct signals into the mixer amplifier 40 and
to prevent the gates from interacting with each other.
However, if at any time, even during the progress of a count, the
oximeter should detect an oxygen deficiency, that is, a blood
condition a predetermined degree below 100 percent oxygen
saturation, the device 33 is actuated to impress a high d.c. level
signal upon the signal mixer amplifier 40. Because this high d.c.
level signal is greater than any d.c. level ever applied to
amplifier 40 either by device 31 or by device 32 the signal from
device 33 is predominant and immediately re-sets the multivibrator
28 to produce a longer on-time of the valve 20, thereby quickly
increasing the supply rate of oxygen to the user. Amplifier circuit
40 contains appropriate amplitude sensitive circuitry, including
resistors, to allow the signal from device 33 to override the
signal coming from either 31 or 32.
While illustrative forms of apparatus and methods in accordance
with the invention have been described and shown herein, it will be
understood that numerous changes may be made without departing from
the general principles and scope of the invention.
* * * * *