U.S. patent number 3,732,864 [Application Number 05/150,654] was granted by the patent office on 1973-05-15 for inhalation coordinated aerosol dispensing device.
This patent grant is currently assigned to Schering Corporation. Invention is credited to Ernest LeBreton, Robert E. Thompson.
United States Patent |
3,732,864 |
Thompson , et al. |
May 15, 1973 |
INHALATION COORDINATED AEROSOL DISPENSING DEVICE
Abstract
An aerosol dispensing device for discharging a metered amount of
a medicament-containing aerosol into the mouth of a patient by
manual compression thereof, which can be discharged only during
inhalation by the patient or by first tilting the device from its
normally vertical dispensing position to a horizontal position,
thereby releasing a gate which normally blocks actuation of the
device.
Inventors: |
Thompson; Robert E. (Maplewood,
NJ), LeBreton; Ernest (Lake Hiawatha, NJ) |
Assignee: |
Schering Corporation
(Bloomfield, NJ)
|
Family
ID: |
22535456 |
Appl.
No.: |
05/150,654 |
Filed: |
June 7, 1971 |
Current U.S.
Class: |
128/200.23 |
Current CPC
Class: |
A61M
15/009 (20130101); A61M 15/0095 (20140204) |
Current International
Class: |
A61M
15/00 (20060101); A61m 011/00 (); A61m
015/06 () |
Field of
Search: |
;128/173,208,201,266,225,211 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: Frinks; Ronald L.
Claims
What is claimed is:
1. An aerosol metering device for inhalation comprising:
a housing having a breathing tube and a spaced vent opening
communicative therewith;
means for dispensing a medicament-containing aerosol into the
housing comprising a dispensing element reciprocally received in
said housing and actuated upon inward reciprocation thereof to
dispense a dose of the contents thereof into said breathing
tube;
a pivotally mounted vane disposed in said breathing tube, said vane
having an upper member positioned in alignment with said dispensing
element so as to normally block depression of said dispensing
element and a lower member rigidly connected thereto by means of an
intermediate pivot which is offset from said upper member, whereby
said vane is inhalation actuated so as to be pivotally moved out of
alignment and blocking position of said dispensing element, such
that depression of said element during inhalation dispenses a dose
of medicament-containing aerosol into said breathing tube.
2. A device according to claim 1 wherein the means for dispensing
the aerosol into the breathing tube is a pressurized container
having a reciprocally actuated dispensing valve reciprocally
mounted in said housing to dispose said valve in engaging
relationship with the interior thereof, such that reciprocation of
said container results in actuation of said valve.
3. A device in accordance with claim 1 wherein said vane is
pivotally mounted so as to be gravity actuated in a blocking
position.
4. A device in accordance with claim 3 wherein said vane is
configured and weighted to move out of blocking position of said
dispensing element when said breathing tube is pointed
downwardly.
5. A device in accordance with claim 3 wherein said vane is
configured and weighted to remain in blocking position of said
dispensing element in both upright and downwardly pointed positions
until breath actuated into a non-blocking position.
6. A device in accordance with claim 1 wherein said vane is
configured so as to permit air to flow through said breathing tube
while said vane is in its blocking position.
7. A device in accordance with claim 6 wherein said vane is
pivotally mounted so as to be gravity actuated in a blocking
position.
8. A device in accordance with claim 7 wherein said vane is
configured and weighted to move out of blocking position of said
dispensing element when said breathing tube is pointed
downwardly.
9. A device in accordance with claim 7 wherein said vane is
configured and weighted to remain in blocking position of said
dispensing element in both upright and downwardly pointed positions
until breath actuated into a non-blocking position.
Description
BACKGROUND OF THE INVENTION
Aerosol dispensing devices which discharge a metered amount of a
medicament as an aerosol upon finger compression thereof are well
known. See U.S. Pat. No. 3,001,524. A problem associated with the
use of such devices is syncronizing the discharge of the medicament
with inhalation by the patient so that the medicament is inspired
deeply into the lungs. If a patient is uncertain whether he has
inhaled the medicament deeply, he sometimes will actuate the device
several times, which can lead to dangerous overdosage. Also, if the
propellant is not diluted by inhaled air, damage to or spasms of
the upper respiratory tract can occur. Therefore, several devices
have been developed which are inhalation-actuated. See U.S. Pat.
Nos. 3,157,179; 3,187,748; 3,302,834; 3,456,644; 3,456,645; and
3,456,646. Such devices are air-actuated, i.e., the device is first
compressed manually to prepare if for actuation by inhalation by
the patient, which triggers a mechanism which releases a metered
amount of the aerosol. Some such devices are triggered only by a
build-up of a vacuum produced by the patient sucking on the
mouthpiece, see U.S. Pat Nos. 3,157,179 and 3,302,834, which can be
difficult for a patient having an asthmatic attack. The prior art
devices which do not block the flow of inhaled air are discharged
from a cocked position by the force of a stream of inhaled air,
which require delicate and relatively complicated construction to
ensure that the force which maintains the device in cocked but not
discharged condition is overcome by the slight force imparted by a
stream of inhaled air. All of the air-actuated devices of the prior
art suffer from the deficiency that they cannot reliably be
discharged by the breath of a patient whose breath is too weak to
release the cocked mechanism.
It is therefore an object of this invention to provide an
inhalation-coordinated aerosol dispensing device of simple,
reliable and inexpensive construction. Another object is the
provision of such a device which requires a very slight flow of
inhaled air to permit discharge thereof. A further object is the
provision of such a device which can be discharged, if desired, by
means other than the force of inhaled air. It is another object of
this invention to provide such a device which precludes
unintentional multiple dosing by furnishing a system which must be
first actuated by inhalation and then by mechanical depression for
each inhaled breath of the user.
SUMMARY OF THE INVENTION
An inhalation-coordinated aerosol dispensing device is provided
with a pivotally mounted vane, positioned in a chamber which
provides communication between an air inlet and a medicament
discharging outlet, which blocks the compression-activation of the
aerosol valve and the air inlet until shifted to a non-blocking
position by a stream of inhaled air or, optionally, also unless the
device is tilted from its normal vertical-dispensing position to a
downward-pointing horizontal position.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is an elevational view, partially in section, of a device in
accordance with the invention;
FIG. 1a is an enlarged fragmentary sectional view of another
embodiment incorporating features in accordance with the
invention;
FIG. 2 is a bottom view, partially in section along line II--II of
FIG. 1; and
FIG. 3 is a side elevation view.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In FIGS. 1, 2 and 3 the device is seen to comprise a housing 10
with a cylindrical portion 12 formed in the upper surface thereof
to slidably receive an aerosol dispensing container 14 therein. The
container is conventional in the art and generally includes a
hollow valve stem or movable element 16 which transmits a metered
dosage of aerosol under pressure from within the dispenser 14 when
the stem is depressed against spring pressure into the container.
As described above, the contents of the dispenser can include any
of the known medicaments for treating respiratory problems.
The housing 10 further includes a breathing tube 18 mounted normal
to the cylindrical portion 12 and forming an intersection
therewith. A nozzle member 20 is mounted on the bottom of the
housing 10 in alignment with the breathing tube 18 and is provided
with an opening 22 in the upper side thereof communicating with the
nozzle and positioned and adapted to receive the stem 16 of the
dispenser 14. As can be seen, then, depression of the dispenser 14
to actuate the valve stem 16 by contact with the nozzle member on
downward movement of the dispenser in the cylindrical portion 12
causes a dose of aerosol to be discharged through the nozzle member
into the breathing tube 18.
Positioned at the opposite end of the housing 10 from the breathing
tube 18 are vent openings 24 which open to the ambient for purposes
to be described below. A vane 26, pivotally mounted on an axle 28
with an upper member 27 and lower member 29 offset in opposite
directions from axle 28, is disposed within the housing 10 between
the vent openings and the breathing tube 18 and subjacent to the
lower portion of the dispenser 14. The vane is pivotal in the
direction indicated by the arrow and is normally positioned in the
illustrated configuration under the influence of a counterweight 30
and is blocked from further counterclockwise rotation by a stop 32.
As can be seen by reference to the figure, the vane 26 is so
configured and positioned to normally block downward movement of
the dispenser 14 thereby normally precluding depression of the
dispenser 14 and dispensation of a dose of aerosol through the
nozzle 20.
In normal operation, the user places his mouth over the breathing
tube 18 and inhales, thereby drawing air through the vent openings
24 and deflecting the vane 26 in a clockwise direction. Deflection
of the vane 26 moves the portion thereof normally positioned below
the dispenser 14 from beneath the lower end thereof, thereby
freeing the dispenser for downward movement thereof within the
cylindrical portion 12. The dispenser 14 is then depressed and a
dose of aerosol is dispensed into the breathing tube 18 and lungs
of the user. When pressure is released on the dispenser 14, the
spring (not shown) contained within the mechanism for maintaining
the valve stem 16 extended, returns the dispenser to the
illustrated position and the vane 26 is rotated counterclockwise by
the counter weight 30 to resume a blocking position. Additional
doses require an identical, two phase, repetition of the
above-described procedure.
In the event that a user is unconscious and respiration is slight,
the device may be used by placing the device in the mouth of the
user with the cylinder portion 12 in a horizontal position and the
axis of breathing tube 18 vertical. In this position, the counter
weight 30 swings the vane 26 open, thereby allowing the medicament
to be administered at will, as shown in FIG. 2.
The configuration of the vane may be varied as desired and the
self-opening feature of the vane may be omitted if so desired. In
FIG. 1a a variation of the vane configuration is illustrated.
Components of this embodiment corresponding to those of the
preceding embodiment are indicated by like numerals of the next
higher order. In that embodiment, the vent opening 124 is disposed
through the lower wall of the housing 110 and the vane 126 is in an
inverted "L" shaped configuration mounted on the axle 128 above the
vent opening. Air passes in the direction indicated by the arrows
and deflects the vane clockwise when the user inhales as was
described above. Rotation of the housing 110 to point the breathing
tube 118 downward will not result in opening of the vane 126
automatically.
The disclosed device, in both its disclosed forms, precludes the
administration of medicament in its upright position without prior
inhalation followed by mechanical actuation. The danger of
overdosage by multiple actuation is therefore minimized. Because
air can flow around the top portion 27 of vane 26 even before it is
moved to its unblocking position, the patient does not experience a
feeling of suffocation while the vane 26 is in its blocking
position.
What has been set forth above is intended primarily as exemplary to
enable those skilled in the art to practice the invention.
From the foregoing description, one skilled in the art can easily
ascertain the essential characteristics of this invention, and
without departing from the spirit and scope thereof, can make
various changes and modifications of the invention to adapt it to
various usages and conditions.
* * * * *