U.S. patent number 3,727,602 [Application Number 05/110,445] was granted by the patent office on 1973-04-17 for instrument for taking samples from internal organs.
This patent grant is currently assigned to SAID Hyden and Victor, by said Larsson. Invention is credited to Victor Holger Hyden, Sune Torsten Larsson.
United States Patent |
3,727,602 |
Hyden , et al. |
April 17, 1973 |
INSTRUMENT FOR TAKING SAMPLES FROM INTERNAL ORGANS
Abstract
An instrument for taking samples from internal organs of humans
and animals in which a cannula for insertion into the organ is
detachably connected to a handle portion provided with a plunger
pump for drawing the sample into the cannula and a needle of
homogeneous material is secured in the pump plunger for axial
movement within the cannula and serves to prevent undesired
fragments of connective tissues entering the cannula when the
cannula passes through the tissues surrounding the internal organ
being sampled.
Inventors: |
Hyden; Victor Holger (412 71
Goteborg, SW), Larsson; Sune Torsten (Goteborg,
SW) |
Assignee: |
SAID Hyden and Victor, by said
Larsson (N/A)
|
Family
ID: |
20273549 |
Appl.
No.: |
05/110,445 |
Filed: |
January 28, 1971 |
Foreign Application Priority Data
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Jun 15, 1970 [SW] |
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8251/70 |
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Current U.S.
Class: |
600/566;
604/164.11 |
Current CPC
Class: |
A61B
10/04 (20130101); A61B 2090/034 (20160201); A61B
10/0283 (20130101) |
Current International
Class: |
A61B
10/00 (20060101); A61B 19/00 (20060101); A61b
010/00 () |
Field of
Search: |
;128/2B,2R,305,310,329,311,304,278,347,218C |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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193,900 |
|
Mar 1923 |
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GB |
|
459,483 |
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May 1928 |
|
DD |
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587,586 |
|
Jan 1959 |
|
IT |
|
187,228 |
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Apr 1967 |
|
SU |
|
Primary Examiner: Howell; Kyle L.
Claims
We claim:
1. An instrument for taking tissue samples from internal organs of
humans and animals comprising a tubular body having an open end and
a closed end, a plunger mounted for axial movement within the body,
said body and plunger constituting a vacuum pump, with said body
also serving as a handle for the instrument, a cannula constituting
a sampling portion of the instrument, said cannula having an outer
diameter of about 0.4 mm, means detachably connecting the cannula
to the open end of the body, a needle of homogeneous material,
means resiliently supporting the needle in the plunger, said needle
extending through the open end of the body into the cannula and
terminating in a point located immediately outside the end of the
cannula when the plunger is at the end of its stroke towards the
open end of the body, the outer diameter of the needle and the
inner diameter of the cannula being such as to provide a narrow
annular gap between the needle and cannula, said gap allowing for a
pressure balance between the cannula and the body upon movement of
the plunger from the open end toward the closed end of the body yet
preventing the passage of the tissue sample past the point of the
needle during the movement of the needle with thee plunger, said
body having an axial slot therein, means attached to the plunger
and projecting through said axial slot, a member slidably mounted
on the outside of said body to which said attaching means is
secured, the length of the axial slot limiting the stroke of the
plunger, and said body having an aperture in proximity to the open
end of the body to provide communication between the body and the
outer air, said aperture being closed when the plunger is adjacent
the open end of the body but being exposed when the plunger moves
toward the end of its stroke in the direction of the closed end of
the body after a tissue sample has been drawn into the cannula to
effect the pressure balance.
2. The instrument according to claim 1, characterized in that said
attaching means is a spring clip and said slidably mounted member
is a cover plate.
3. The instrument according to claim 1, characterized in that the
resilient supporting means for the needle comprises a twice-folded
resilient holder and an axial cylindrical hole in the plunger
having a widened mouth to form a conical guide into which the
holder may be inserted and removed.
Description
BACKGROUND OF THE INVENTION
This invention relates to an instrument for taking samples from
internal organs of human beings and animals.
PRIOR TECHNIQUES
A pathologic change of cells in an internal organ, for example the
liver, requires an early and safe diagnosis for allowing the curing
of the condition by simple means. Sucn pathologic changes
heretofore have been diagnosed by an indirect method, viz. by
examining the body liquids secreted from the organ in question.
This indirect method, however, did not allow for a sufficiently
early diagnosis which was its greatest disadvantage. When using a
direct method by taking a small tissue sample from the organ, the
diagnosis can be made at a very early stage. For this reason, the
direct method was introduced for trial purposes. Due to the absence
of an instrument of greater suitability, a usual hypodermic syringe
was used and which was provided with a relatively large cannula
having an outside diameter of about 2 mm and a conventionally
ground down point into which a tissue sample was sucked. The tissue
samples thus taken are to a high degree mixed with connective
tissues from the tissues surrounding the internal organ in
question. For this reason, introduction was made of the method of
placing into the cannula a needle of a homogenous material, and
removing the needle after the cannula had penetrated through the
tissues in front of the organ into the organ. The quality of the
sample thus taken was improved, but the sampling technique showed
certain disadvantages restricting its application. The large
cannula, as a matter of fact, in many cases gave rise to
complications in the form of bleedings and infections and was
somewhat painful for the patient.
A device for taking samples from internal organs which was
developed at a later date utilizes a capillary cannula with an
outer diameter of 0.3 - 0.4 mm, the point of which is cut off
perpendicularly and ground to a cone angle of 40.degree. -
50.degree. to form a circular edge. With this device, the
inconvenience and the risk of complications are at a minimum, and
the sample taken, when correctly applying the sampling technique,
is substantially free of undesirable connective tissue fragments.
The device, however, is not entirely satisfactory since it involves
obtaining an accurately adjusted vacuum of about 150 mm
water-column for sucking the sample into the cannula. A further
objection is that this vacuum has to be connected to a separate
pump or suction hose, which has made it relatively difficult to
handle the device in practical use.
SUMMARY OF THE INVENTION
The instrument according to the invention provides a complete unit
for easy handling, comprising a cannula detachably connected with a
handle portion, which includes a plunger pump for drawing the
tissue sample into the cannula. By applying the older idea of
utilizing a needle of a homogenous material in the cannula in a
new, improved manner, the difficulties of accurately adjusting the
vacuum are avoided and at the same time the sampling technique is
improved and simplified. By securing the needle in the plunger, it
draws itself automatically back out of the cannula when the sample
is being sucked in, and the sample cannot, by the strong vacuum, be
sucked up through the cannula to the pump. The cannula preferably
is so designed in accordance with the above mentioned prior art
device that the advantages of a capillary canula with its special
grinding of the point can be utilized. The outer diameter possibly
is to be increased to about 0.5 mm, for preventing the needle from
being so thin that it would be uncomfortable to insert the needle
into the cannula when the instrument is to be cleaned and
sterilized. This increase in diameter by some tenth of a millimeter
is so insignificant that it does not imply any disadvantages. The
needle diameter is so adjusted in relation to the inner diameter of
the cannula that the play therebetween allows the pump to effect
sucking through the gap formed, but prevents the tissue sample
sucked in to pass the needle. The length of the needle is so
adjusted that its free end terminates immediately outside of the
cannula mouth when the plunger is in its end position closest to
the cannula. When a desired sample quantity has been sucked into
the cannula, a pressure balance takes place which interrupts the
sucking operation, due to the fact that the plunger on its way
exposes a connection to the outer air. The plunger is actuated by a
sliding portion on the front part of the handle. The sliding
portion is mounted on a cover plate covering a gap, in which a
spring clip runs which is secured on the lower surface of the cover
plate. The spring clip embraces the plunger in a groove and acts as
a carrier. The gap in the pump tube limits the pump stroke. The
outer cross-section of the handle can be given a round shape or,
which is more advantageous, an angular shape with slightly rounded
corners, or it may be given another suitable shape providing a
comfortable and safe grip for the hand holding the instrument in
the manner of a thick pencil.
In order to avoid the risk of transferring to the patient, for
example, infectious yellow jaundice by an unsatisfactorily
sterilized cannula, use is made increasingly of throw-away
instruments, for example hypodermic syringes, packed in sterile
packages and discarded after use. These instruments are assembled
of a few simple plastic parts, and as only the cannula is of metal,
these instruments are quite inexpensive. The principle can be
applied alternatively to an instrument according to the invention.
The instrument in such case can be manufactured to be of the
throw-away type in its entirety, or it may be sufficient to
manufacture only those instrument parts for discard which are to be
inserted into the body tissues, i.e. the cannula and the needle.
The invention is designed so as to allow for a rapid and simple
mounting and dismounting of the cannula and needle.
A preferred embodiment of the instrument is described in greater
detail in the following, with reference to the accompanying
drawing.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a view of longitudinal section through the instrument,
with the plunger being in its forward position,
FIG. 2 is a view taken along the line II-II in FIG. 1, the view
looking in the direction of the arrows,
FIGS. 3 and 4 are fragmentary views showing details of the front
part of the cannula on an enlarged scale with the needle controlled
by the plunger, in which FIG. 3 shows the needle position when the
plunger is fully inserted, and
FIG. 4 the needle position when the plunger is fully retracted,
and
FIG. 5 is a fragmentary view illustrating the manner in which the
needle is secured in the plunger.
DETAILED DESCRIPTION OF THE INVENTION
The instrument shown in FIG. 1 comprises a tubular body defining an
elongated pump tube 1 having a hexagonal outer cross-section with
slightly rounded corners, FIG. 2, so as to provide a safe and
comfortable grip for the hand. The grip is improved in that the
forward portion of the pump tube 1 is knurled. In the forward
portion of the pump tube 1 is movably arranged a long plunger 2
provided with a sealing ring 4 mounted in a groove 3 in the
plunger. The plunger 2 is actuated by a finger portion 5 on a cover
plate 6 which is connected with the plunger 2 by a spring clip 7
embracing a groove 19 in the plunger 2. A slot 8 for the spring
clip 7 is provided in the pump tube 1 and limits the length of the
pump stroke. An aperture 9 in the pump tube 1 connects the interior
of the pump tube 1 with the outer air and brings about a pressure
balance immediately prior to the arrival of the plunger 2 at its
retracted end position, when the aperture 9 is exposed after a
sufficiently great tissue sample has been sucked into the
instrument. The rearward portion of the pump tube 1 is closed by a
rounded plug 10, and the forward portion of tube 1 is designed as a
reduced end piece 11 having an axial through bore and a gasket 12.
On the forward portion of the end piece 11, a quick-coupling 13 of
a bayonet type serves to detachably connect a capillary sampling
cannula 14 to the end piece. The cannula 14 has a pointed end 15,
FIGS., 3 and 4 which preferably is ground conical to form a sharp
circular edge, but it also may have another suitable form (not
shown). In the plunger 2, a needle 16 of a homogeneous material is
fastened and the needle extends through the axial bore in the end
piece 11 and the cannula 14 and terminates in a point 17. The point
17 extends immediately outside of the pointed end 15 of the cannula
14 when the plunger 2 is in its inner end position (FIG. 3). The
diameter of the needle 16 is so adjusted in relation to the inner
diameter of the cannula 14 as to form a narrow gap 18 therebetween,
which, during the pumping operation, allows for a pressure balance
between the cannula 14 and the interior of the pump tube 1, but
which is sufficiently narrow to prevent the tissue sample taken
from passing past the point 17 of the needle (FIG. 4).
For enabling a rapid exchanger or replacement, the needle 16 is
mounted detachably in the plunger 2, and more specifically, the
plunger 2 is provided with an axial cylindrical hole 20, the
forward portion or mouth of which is widened to provide a conical
guide 21 for a twice-folded resilient holder 22 of the needle 16.
Upon mounting the needle 16, the resilient holder 22 is moved in
the direction of the arrow against the plunger 2 with the insertion
into the hole 20 being facilitated by the guide 21. The needle 16
having reached the bottom of the hole 20, is resiliently secured in
the plunger 2. The force of resilience is sufficient for the needle
16 to participate in the movements of the plunger 2, but the force
is such that the needle easily can be withdrawn from the hole 20
for exchange purposes. The length of the needle 16 is so adjusted
that it projects after mounting, some distance outside of the
pointed end 15 of the cannula 14. This piece is cut off to align
with the pointed end 15.
Before sampling, it is desirable to make certain that the joints
between the end piece 11 and the quick-coupling 13 and between the
quick-coupling 13 and the cannula 14 respectively are tight. This
can be simply effected by sucking up into the instrument, a liquid
innocuous to the body tissues, for example a sterile isotonic
saline solution which thereafter is sprayed out of the instrument.
The liquid residue remaining in the gap 18 and in cavities behind
the gap does not disturb the sampling, but acts as an additional
barrier, not necessary per se, when thee instrument passes through
the tissue in front of the organ in question.
The instrument is then held similar to a pencil with one finger on
the sliding portion 5, which is held in its forward position while
the cannula 14 is inserted through the tissue surrounding the organ
until the pointed end 15 reaches the sampling area in the internal
organ. The plunger 2 is slowly retracted by means of the sliding
portion 5 at the same time as the cannula 14 is inserted an
additional short distance whereby a tissue sample is sucked into
the forward portion of the cannula 14 in front of the returning
needle 16. When the plunger 2 exposes the aperture 9, the vacuum in
the instrument is balanced, and the suction of the tissue sample is
completed. The instrument can now carefully be pulled out while the
plunger 2 still is in its retracted position. The sample then
removed from the cannula 14 for examination by moving the plunger 2
to its forward position.
The design of the individual parts as well as the choice of the
construction material can be varied to a substantial degree without
departing from the basic idea of the invention. It can be imagined,
for example, to manufacture the instrument of metal and/or glass,
with a constructional design which is suitable in such a case, not
the least in consideration of a repeated use of the instrument, or
the instrument can be given a highly simplified design, with most
of the details made of plastic, when the instrument is intended to
be discarded after use.
* * * * *