U.S. patent number 3,722,502 [Application Number 05/190,143] was granted by the patent office on 1973-03-27 for multiple liquid sample collection apparatus.
Invention is credited to Sidney Besuner, Richard L. Pardun.
United States Patent |
3,722,502 |
Besuner , et al. |
March 27, 1973 |
MULTIPLE LIQUID SAMPLE COLLECTION APPARATUS
Abstract
A liquid sample collection apparatus which includes a collection
receptacle with a plurality of joined but separable sample
collection units. A liquid transmitting tube may be selectively
positioned to discharge into a desired collection unit, without
exposure to atmosphere and without sample cross-contamination. The
tube has an outlet which is insertable through internal openings to
the respective units. When a sample has been collected in one unit,
the flow of fluid is stopped and the outlet end of the tube is
withdrawn from the particular unit, but remains within the overall
receptacle. The opening between the filled unit and its adjacent
unit is then sealed, and the filled unit is separated from the
receptacle. The whole system remains sealed to external
contamination through successive sample collections and
separations.
Inventors: |
Besuner; Sidney (Ft. Thomas,
KY), Pardun; Richard L. (Cincinnati, OH) |
Family
ID: |
22700181 |
Appl.
No.: |
05/190,143 |
Filed: |
October 18, 1971 |
Current U.S.
Class: |
600/575; 604/326;
604/191; 600/580; 600/584 |
Current CPC
Class: |
A61B
5/150389 (20130101); A61B 5/150305 (20130101); A61B
5/150366 (20130101); A61M 1/69 (20210501); A61B
5/15003 (20130101); A61B 5/150251 (20130101); A61B
5/150213 (20130101); A61B 10/0045 (20130101); A61J
1/10 (20130101); A61B 5/155 (20130101); A61B
5/150221 (20130101); A61B 10/007 (20130101); A61J
1/2093 (20130101); A61J 1/12 (20130101); A61J
1/2034 (20150501); A61B 5/150992 (20130101) |
Current International
Class: |
A61J
1/00 (20060101); A61M 1/00 (20060101); A61B
10/00 (20060101); A61J 1/14 (20060101); A61b
005/00 () |
Field of
Search: |
;128/2F,214.2,275,295
;150/.5,1 ;53/29,183 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Laudenslager; Lucie H.
Claims
We claim:
1. A multiple liquid sample collection apparatus for collecting
samples such as urine or the like, from a patient, comprising:
a collection receptacle,
a drainage tube for connection to receive a liquid discharged from
a patient and having an outlet end positioned within said
collection receptacle,
said receptacle having a plurality of serially joined but separable
flexible sample collecting compartments, each with at least one
opening to adjacent compartments,
the said openings being arranged so that the outlet end of said
drainage tube is insertable through said openings in sequence to
communicate with each of the compartments, and
means for sealing predetermined ones of said openings subsequent to
removal of the outlet end of said drainage tube and prior to
separation of said separable sample collecting compartments.
2. Apparatus as in claim 1 including a plurality of heat sealed
strips extending from the bottom of the receptacle to points near
the top thereof for separating said compartments,
the said openings being formed through each such strip to permit
passage of said outlet end therepast.
3. Apparatus as in claim 2 including perforation means extending
from one end to the other end of each heat sealed strip for aiding
in the separation of said compartments.
4. Apparatus as in claim 1 wherein said sealing means includes a
plurality of clamp means, each clamp means having two legs provided
with cooperating projection means for engaging and sealing said
openings.
5. Apparatus as in claim 4 including clamp guide means on said
receptacle.
6. Apparatus as in claim 5 wherein said clamp guide means include a
plurality of longitudinal projections extending across the openings
between said compartments.
7. Apparatus as in claim 1 wherein the outlet end of said drainage
tube is provided with a retainer means for holding said end within
a selected compartment.
8. Apparatus as in claim 7 wherein said retainer means is an
enlargement adjacent the end of said tube which restricts free
movement of the tube end through said opening.
9. Apparatus as in claim 1 wherein one of said compartments is a
reservoir substantially larger than the others and includes vent
means and drainage means.
Description
This invention relates to a collecting apparatus and more
particularly to an apparatus for collecting samples of discharged
liquids without outside bacterial contamination. The apparatus is
useful for collecting successive samples from a patient, and is
especially useful for the collection of urine samples for
laboratory analysis to aid in therapeutic treatment of the patient,
although it may be utilized for the collection of blood or other
discharged liquids.
In the collection of liquid samples such as urine, it is important
to collect and maintain the sample free from any external
contamination which may make the sample useless, or render
inaccurate the results of any analysis conducted on the sample.
Moreover, exposure to atmosphere of the drainage passage or tube
may lead to patient infection. Such exposure or contamination may
readily occur through open air exposure of the sample, or exposure
of the tube end which drains into the collection apparatus. The
dangers of such contamination are pointed out in "Clinical
Evaluation of Closed Urinary Drainage Systems" by Finkelberg and
Kunin, J. American Medical Assn., vol. 207, pp. 1657-1662, Mar. 3,
1969, which compares eight different drainage systems for efficacy
in preventing contamination of bladder urine, and later in
"Bacteria During Indwelling Catheter Drainage", by Thornton and
Andriole, J. American Medical Assn., vol. 214, pp. 339-342, Oct.
12, 1970.
In one prior type of collector device, such as the disposable
urinary drainage bag assembly shown in U. S. Pat. No. 3,090,968,
contamination can be introduced into the sample through the opening
in the bag provided for the outlet end of the drainage tube.
Moreover, when a replacement bag is mounted to the drainage tube
for a subsequent sample, the outlet end and internal passage of the
drainage tube can become contaminated by air exposure. No provision
is made for successive sampling, without drain tube exposure.
We have invented a collection apparatus which provides a closed
system for the collection of samples, such that multiple samples
can be successively introduced to and removed from the apparatus
without exposing the interior thereof, or the drainage tube, to any
external contamination. By this apparatus a plurality of samples
may be taken, at different times, without exposing the system or
the drainage tube at any time to external contamination, each
successive sample-containing unit being separable from the
remaining apparatus.
One prior art device which provides for plurality of separable
blood collection units is disclosed in FIG. 10 of U. S. Pat. No.
2,702,034. Such prior art devices are utilized for collecting an
adult donation of blood and automatically dividing it into several
infant-size infusion quantities. A common inlet to all smaller
units is utilized, thus each sample compartment is opened to the
other and the liquid in each compartment is subject to
cross-contamination and overflow from the adjacent compartment if
successive samples were to be taken. Such devices have no apparatus
for the selective filling of a single removable compartment.
It has been a major object of this invention to provide apparatus
including a closed system for the collection of successive and
separable liquid samples, the apparatus being closed to external
contamination throughout the collection of the various samples.
Another object of the invention has been to provide a liquid
collection apparatus for the collection of successive liquid
samples into compartments separable from the apparatus, wherein
each compartment is filled separately and individually, without
flow to or from the adjacent compartment.
Briefly, our invention includes a plastic collection bag divided
into serially joined units or compartments, and a drainage tube
disposed within the bag which is extendable or introduceable
through openings near the tops of the respective compartments. The
tube has an outlet end and a retainer that is selectively
positionable within any given compartment, the retainer holding the
outlet end within the selected compartment. The compartment to
which the tube end opens receives liquid from the drainage tube
when an appropriate tube clamp is opened. When the desired amount
of liquid has been obtained, the clamp is closed and the outlet end
of the tube and retainer are withdrawn through the compartment
opening so as to reside within another compartment in the bag. The
opening of the filled compartment is thereafter sealed by a clamp
or other sealing means, and thereafter the sealed compartment is
removed from the bag for transportation to a laboratory for
analysis of the sample therein. The compartment which was adjacent
to the removed compartment remains sealed against external
contamination by sealing means utilized subsequent to the tube's
withdrawal, but prior to removal of the filled compartment.
The tube may be withdrawn into a larger, vented main compartment or
reservoir which accepts regular liquid flow, until another sample
is desired. The tube is then "threaded" or pushed through the
compartment openings to what is now the last compartment, for the
collection of another sample.
The compartmented apparatus may be formed from a plastic bag by the
process of heat sealing strip areas of the bag together to define
the various compartments. The sealing of the compartment openings
after filling may be accomplished by a mechanical seal, by heat
sealing, or in other manner. Perforations or tear lines may be
formed in the heat sealed areas of the bag in order to facilitate
individual removal of the various compartments.
The invention thus is capable of collecting a plurality of
sequential samples at different times, and yet maintaining the
entire collection system closed to external contamination.
The invention has the further advantage that the apparatus can be
utilized over a long period of time, the regular flow of fluid
being delivered into a larger compartment and drained therefrom as
necessary through an appropriate outlet. The drainage tube may be
inserted into a sample compartment only at such time as a sample is
required, and the whole system remains closed to external
contamination as well as to internal cross-contamination.
These and other objects and advantages will become readily apparent
from the following detailed description of a preferred embodiment
and from the drawings, in which:
FIG. 1 is a general side elevation of the apparatus showing the
compartmented drainage bag and drainage tube;
FIG. 2 is taken along line 2--2 of FIG. 1 and shows an enlarged
horizontal section of the lower portions of the separable
compartments;
FIG. 3 is taken along line 3--3 of FIG. 1 and shows an enlarged
horizontal section of the upper portions of the separable chambers
including the clamp guides and a pair of clamps;
FIG. 4 is an enlarged vertical view taken along line 4--4 of FIG. 1
and shows a clamp in operative position; and
FIG. 5 is an enlarged horizontal sectional view of a clamp, taken
on line 5--5 of FIG. 4.
Now referring particularly to the drawings, a preferred form of
drainage bag or collection receptacle 10 embodying the invention is
shown in FIG. 1 thereof. The bag 10 may be made from any suitable
material such as thermoplastic sheet material, e.g., polyethylene,
and includes a large compartment or reservoir 11 and separable
compartments or units 12-15 connected to the main reservoir. The
relative sizes of these are not critical, but the compartments
12-15 could usefully be of 50cc capacity, and reservoir 11 of
1800cc capacity.
The separable units 12-15 are separated from each other and from
the large compartment 11, preferably by heat sealing the sides of
the bag 10 together along spaced parallel strips 16-19. The heat
sealed strips extend from the bottom 20 of bag 10 (as seen in FIG.
1) to points 21 short of the top 22 of the bag 10, thus leaving a
passageway or open zone 8 between the points 21 and the top 22 of
the bag. The passageway 8 is best seen in FIG. 3, between
compartments 14 and 13, 13 and 12, and 12 and 11. The opening
between compartments 14 and 15 is shown sealed, as will be
discussed. Perforations or tear lines 9 extend from the bottom 20
of the bag 10 to the points 21 in the middle of the heat sealed
strips 18, and aid in separation of the compartments as will be
discussed.
The large compartment or reservoir 11 of the bag includes a typical
pledget 23 which commonly includes a plug of cotton or other
material for providing a vent in compartment 11. Although air can
pass through the pledget 23, it maintains the bag closed to
external contamination.
A liquid outlet or drain 24 is provided at the bottom of
compartment 11 for the purpose of draining liquid from the
compartment 11 through an outlet or discharge tube 25. This tube is
provided with a clamp 26 which may be opened or closed, either to
drain or seal the compartment 11. It is to be noted that the
drainage of compartment 11 through the tube 25 does not allow
external contamination into the bag 10, because clamp 26 is only
opened while fluid is flowing out of tube 25 and is closed before
air enters port 24. The liquid flow itself seals the bag against
the introduction of external contamination through this outlet.
A drainage tube 30 is provided for introducing liquid into the bag
10. The tube enters the bag through a fixed, sealed opening 29. The
tube 30 includes an enlarged diameter circular retainer 31 located
near the end 32 of the tube. The retainer may be an integral part
of the tube 30, or it may be washer-shaped and fitted tightly onto
tube 30. The retainer has an outside diameter of such dimension
that it may be manually worked through the openings 8 provided
between the various compartments. The fit of the retainer in these
openings is such that the retainer will nto freely pass through the
openings but effectively act as a stop when it abuts one of the
openings. It thereby prevents inadvertent withdrawal of the tube
end from the particular compartment in which it has been
placed.
The retainer is not so large, however, that it cannot be pulled
through the opening when desired. To this end, the retainer may be
made of a deformable material, or the material from which the bag
is made may be yieldable to allow the retainer and tube to pass
through the opening by a predetermined force.
For attachment of the bag 10 to collect a sample of liquid from the
patient, tube 30 may be attached to a tube 35 or catheter of known
type, connected to the patient for receiving the discharge liquid.
A clamp 36 is provided on tube 30, or on tube 35, to valve the flow
of liquid as will be described.
For sealing off one of the separable compartments 12-15 from the
others, a clamp 40 such as the preferred clamp shown in FIGS. 4 and
5 may be utilized. Such a clamp may be "hairpin" or U-shaped, and
comprises longitudinal legs 41 and 42, hinged or joined at 44. The
legs are provided with vertically extending interfitting grooves 43
which cooperate with serrations in the opposite leg as shown in
FIG. 5. The clamp may be pushed over the top portion 22 of the bag
10 and downwardly, thereby gripping the bag material in the
saw-tooth or serration portion of the clamp. The legs of the clamp
are yieldable, but are urged toward each other so as to clamp
together material over which the clamp is applied.
Two clamps are provided for each opening associated with each heat
sealed strip, so that each end of an opening 8 can be sealed when a
compartment is to be separated from the bag 10. Guides or clamp
confinements 45 are provided as shown in FIGS. 1 and 3 to prevent
the clamps from any slide slippage. These guides are located, as
shown in FIG. 1, on each side of the perforations 9 and are merely
longitudinal ribs, guides or projections, and may be extruded,
pressed, molded or otherwise combined with the sides of bag 10 in
any suitable manner.
A hanger loop 50 is provided on the bag 10 in order to facilitate
the hanging of the bag in an appropriate position for receiving a
liquid. Graduations as at 51 may be printed, to show liquid
volume.
In use, to collect samples, such as urine samples from a patient,
the bag 10 is hung appropriately near the patient and the tube 30
is connected to the catheter tube 35, which in turn is connected to
the urinary bladder. During normal use, the end 32 of the tube is
located within reservoir compartment 11 of the bag and the regular
fluid flow is received and contained therein. This compartment may
be drained as necessary by the opening of clamp 26 on outlet tube
25.
When it is desired to analyze the flow at the specific time, or
over a certain period, the clamp 36 is closed to stop liquid flow
through tube 30. The tube end 32 is then moved relatively through
the openings 8 by pulling and sliding the compartments over the
retainer 31 of tube 30 in an accordion-like fashion, until the end
32 of tube 30 protrudes into the last or farthest compartment 15.
During this operation, the tube does not slide with respect to the
seat at 29. Clamp 36 is then released, and the sample is discharged
into compartment 15 only. During the collection of the sample in
compartment 15, the retainer 31 holds the end 32 of tube 30 within
this compartment. When the desired sample has been collected, clamp
36 is closed, and the outlet end 32 of tube 30 is retracted through
the openings back into large compartment 11. Clamp 36 may then be
opened to pass the normal liquid flow into this compartment. This
procedure maintains the other compartments free of any fluid
discharge through tube 30 during movement of outlet end 32 through
the various openings.
In order to seal and separate the compartment 15 from the bag 10,
two clamps 40 are placed into operative position between their
respective guides 45, as best seen in FIGS. 1 and 3. These clamps
effectively seal closed the opening between compartments 15 and 14,
and the sample may now be removed from the bag 10 by merely tearing
or cutting compartment 15 away from compartment 14 along the
perforations 9 in the heat sealed strip 19. It is to be understood
that the heat sealed strip 19. It is to be understood that the heat
sealed strips are wide enough to form effective seals even when the
units are torn apart along the perforations. When the compartment
15 has been separated up to the point 21 where the perforations
end, the remaining material may be cut between the clamps to
complete the separation of the sample.
The sample, completely sealed within compartment 15 by one clamp
40, may be transferred to the laboratory for analysis. The bag 10
remains sealed by virtue of the remaining clamp 40 on what is now
the end compartment 14. Successive samples may be obtained by
repeating the same procedure. As can be seen, tube end 32 has at no
time been exposed to atmosphere.
It can be appreciated that many alternatives may be provided. For
instance, after the collection of a sample into a sample
compartment and withdrawal of tube 30 therefrom, the opening could
be sealed by any suitable means such as modified clamps or by
further heat sealing.
In an alternate embodiment, the bag 10 may comprise a plurality of
like-sized compartments with the end of the drainage tube disposed
in the last. The tube 35 is connected to a patient (through a
bypass valve or the like) only when a sample is desired. The sample
could then be collected and separated in much the same manner as in
the uses of the preferred embodiment, the end of the drainage tube
being successively retracted into the next adjacent compartment and
the opening sealed before a collected sample is separated.
Thus it can be seen that we have provided a sample collection
apparatus which can be utilized for the collection of urine, blood,
or the like which is discharged from a patient, the apparatus
including a collection system which is constantly sealed against
external contamination. The invention also provides a system
whereby a single apparatus can be utilized in the collection of
successively discharged liquid samples, the system being sealed
against external contamination as well as against internal
contamination between a plurality of separable sample collection
compartments or units.
While we have described preferred and alternate embodiments of the
invention, other modifications and variations will become apparent
to those of ordinary skill in the art and we intend to be bound
only by the appended claims.
* * * * *