U.S. patent number 3,714,956 [Application Number 05/254,733] was granted by the patent office on 1973-02-06 for aseptic storage and valving system.
Invention is credited to Philip E. Nelson.
United States Patent |
3,714,956 |
Nelson |
February 6, 1973 |
ASEPTIC STORAGE AND VALVING SYSTEM
Abstract
A plurality of storage tanks for bulk storage of materials under
aseptic conditions in which valves associated with the tanks have
chambers filled with liquid chemical sterilant surrounding movable
valve actuators for preventing the influx, via the valve actuators,
of contaminants to the material stored in the tanks. The chemical
sterilant is unheated to prevent the transfer of heat from the
sterilant to the stored material. The sterilant chambers are
connected serially to form a cascade between a source of fresh
sterilant and a chemical analyzer, with the chambers which become
more contaminated in use being connected in the cascade more remote
from the fresh sterilant supply. The sterilant chambers are
recharged with fresh sterilant by a flow of fresh sterilant from
the supply through the cascade, which flow is terminated when the
sterilant leaving the last chamber of the cascade upon analysis by
the chemical analyzer has reached a sterile level indicating that
the fresh sterilant has propagated through the cascaded chambers
successively flushing the chambers in the cascade of inactive, or
stale, sterilant and replenishing the chambers with fresh
sterilant. Each sterilant chamber is provided with an inlet passage
and an outlet passage located at the bottom and top of the
chambers, respectively, such that fresh sterilant enters the bottom
of the chamber, forcing inactive, or stale, sterilant from the
chamber through the top, insuring complete recharging of the entire
chamber with fresh sterilant.
Inventors: |
Nelson; Philip E. (West
Lafayette, IN) |
Family
ID: |
22965381 |
Appl.
No.: |
05/254,733 |
Filed: |
May 18, 1972 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
|
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40550 |
May 26, 1970 |
3678956 |
|
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Current U.S.
Class: |
137/238 |
Current CPC
Class: |
A23B
7/00 (20130101); A23B 7/157 (20130101); A23B
7/154 (20130101); Y10T 137/4245 (20150401) |
Current International
Class: |
A23B
7/157 (20060101); A23B 7/154 (20060101); A23B
7/00 (20060101); A23B 7/14 (20060101); F16k
051/00 () |
Field of
Search: |
;21/91,94
;137/15,238,240,241,332 ;99/105,154,155,186 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Klinksiek; Henry T.
Parent Case Text
This application is a continuation-in-part of the pending
application of Philip E. Nelson for "Aseptic Storage and Valving
System," Ser. No. 40,550, filed May 26, 1970, now U.S. Pat. No.
3,678,955.
Claims
Having described the invention, what is claimed is:
1. A method of recharging with fresh chemical sterilant and
flushing stale sterilant from sterilant-containing chambers which
surround movable actuators of aseptic valves, comprising the steps
of
connecting the chambers in series to form a cascade, and
pumping fresh sterilant from a source thereof to the first chamber
of said serially connected cascade of said chambers while
exhausting stale sterilant from the last chamber of said
cascade.
2. The method of claim 1 wherein said connecting step includes
connecting an output passage of each of said chambers located in
the top thereof to an input passage of the successive chamber in
said cascade located in the bottom thereof, and said pumping and
exhausting step includes pumping sterilant from said source into
the input passage of said first chamber and draining sterilant from
the output passage of said last chamber.
3. The method of claim 1 further including the step of analyzing
the sterilant exhausted from said last chamber and terminating said
pumping when the analysis indicates fresh sterilant is being
exhausted from said last chamber.
4. A method of maintaining in an aseptic condition material stored
in a tank having an aseptic valve, the method comprising the steps
of
charging a chamber surrounding a movable actuator of said valve
with a chemical sterilant prior to the time said tank is filled
with the material to be stored,
thereafter periodically recharging said sterilant-containing
chamber with fresh chemical sterilant and flushing stale sterilant
from said sterilant-containing chamber, and
after said material has been loaded into said tank, draining said
sterilant-containing chamber.
5. The method of claim 4 comprising the further step of recharging
said chamber with fresh chemical sterilant prior to and during the
removal of a sample from said tank and subsequently draining said
chamber after said sample has been withdrawn.
6. The method of claim 4 comprising the further step of recharging
said sterilant-containing chamber with fresh chemical sterilant
prior to and during the period in which a portion of the contents
of said tank are withdrawn and emptying said sterilant-containing
chamber after the said portion of the contents has been withdrawn,
whereby the remaining contents of said tank are maintained in
sterile condition.
7. A method of maintaining in an aseptic condition material stored
in a plurality of tanks each having an aseptic valve, the method
comprising the steps of
charging a chamber surrounding a movable actuator of each said
valve with a chemical sterilant prior to the time said tanks are
filled with the material to be stored,
thereafter periodically recharging said sterilant-containing
chambers with fresh chemical sterilant and flushing stale sterilant
from said sterilant-containing chambers, and
after said material has been loaded into said tank, draining said
sterilant-containing chambers.
8. The method of claim 7 comprising the further step of recharging
said chambers with fresh chemical sterilant prior to and during the
removal of a sample from said tanks and subsequently draining said
chambers after said sample has been withdrawn.
9. The method of claim 7 comprising the further step of recharging
said sterilant-containing chambers with fresh chemical sterilant
prior to and during the period in which a portion of the contents
of said tanks are withdrawn and emptying said sterilant-containing
chambers after the said portion of the contents has been withdrawn,
whereby the remaining contents of said tanks are maintained in
sterile condition.
Description
BACKGROUND OF THE INVENTION
This invention relates to the storage of material under aseptic
conditions, and more particularly to an aseptic valving and storage
system suitable for use with storage tanks in which material such
as food, pharmaceuticals, and the like, is stored in bulk form.
In the processing of edible material, and prior to final packaging
in small units for consumer use, it is often necessary to store
large quantities of the material in bulk form and to do so under
aseptic conditions in order to insure ultimate purity of the
material as supplied to the consumer. The problem of aseptically
storing material in bulk form is compounded by two factors. First,
it is often necessary that the material remain in storage tanks for
protracted periods of time, often exceeding 3 months. Such is the
case, for example, in the processing of tomato products which are
sold throughout the year although available for harvesting during
only a few months. When edibles are stored for protracted periods,
contaminants, such as microorganisms, if admitted into the tank,
even when admitted in only small quantity, will eventually
contaminate the entire tank. Such is due to the characteristic
rapid growth, or multiplication, of microorganisms which persists
over the protracted storage period. Contamination of an entire tank
is a particularly acute problem in practice due to the fact that
conventional bulk storage tanks often store 50,000-70,000 gallons
each, and contamination of even one tank therefore represents a
substantial loss.
The second factor aggravating the bulk storage problem is that it
is often necessary to store the bulk material without a change in
its temperature. This is particularly true when the bulk material
has been previously partially or fully processed to a predetermined
desired intermediate or final condition, and change of its
temperature during storage will adversely affect the predetermined
desired condition of the stored material which resulted from its
pre-storage processing. When storage of partially or fully
processed bulk material is required without elevation of its
temperature, it is essential that the means utilized to facilitate
aseptic storage does not transfer heat to the stored material and
thereby occasion undesired increases in stored material
temperature. Since heat transfer to the stored material during
storage frequently must be avoided, utilization of thermal
sterilizing agents such as steam, often a sterilizing agent in
aseptic valving systems, is not feasible since such will in time
result in an undesirable increase in temperature of the stored
material.
SUMMARY OF THE INVENTION
Accordingly, it has been an objective of this invention to provide
means for storing large quantities of bulk material under aseptic
conditions, particularly for protracted periods, and to do so
without increasing the temperature of the stored material. This
objective has been accomplished in accordance with certain of the
principles of this invention by providing storage tanks in which
previously sterilized material can be placed for bulk storage with
aseptic valves which are characterized by having a chamber
surrounding the movable valve actuator which is filled with a
liquid sterilant of a chemical nature. The use of a chemical
sterilant, such as an iodine-based detergent sanitizer, permits
aseptic storage to be effected with an unheated sterilant and,
hence, without the transfer of heat and consequent elevation in
temperature of the stored material as would necessarily occur if
thermal sterilizing agents, such as steam, were utilized.
In addition to facilitating aseptic storage without undesirable
increase in stored material temperature, the use, in combination
with a storage tank, of a chemically sanitized valve vis-a-vis a
thermally sanitized steam valve provides a further advantage.
Specifically, it dispenses with the complications and expense of
generating steam. Steam sterilization is complicated and expensive
because the steam which is generated must be free of mineral
deposits to minimize lime deposits in the steam plumbing. Also, the
steam generating equipment used must necessarily be operated on a
24 hour basis due to the relatively short-lived sterilization
capability of thermal sterilants. Twenty-four hour operation is a
particularly expensive proposition when material is to be stored
for long periods, such as 3 months or more; whereas, a chemically
sanitized valve must be recharged with fresh sterilant on only an
intermittent basis, e.g., once per day, since chemical sterilants
maintain their aseptic nature for extended periods of time.
In accordance with a preferred embodiment of the aseptic storage
and valving system of this invention, the chemical sterilant is in
liquid form and the sterilant chambers of the valves have a
sterilant inlet passage at the bottom of the chamber and a
sterilant outlet passage at the top of the chamber. Utilization of
a chemical sterilant in liquid form with sterilant chambers having
lower and upper sterilant inlet and outlet passages insures that
when sterilant is introduced into the chamber any entrapped air
will be forced upwardly through the sterilant exit passage,
facilitating filling of the entire volume of the chamber with
sterilant. Additionally, location of the sterilant discharge
passage at the top of the chamber enables the entire volume of the
chamber to be filled with liquid sterilant before the sterilant
flows out of the chamber via the exit passage.
It has been a further objective of this invention to provide simple
and efficient means for periodically replenishing, or recharging,
the sterilant chambers of the valve with a fresh supply of
sterilant. This objective has been accomplished in accordance with
certain principles of this invention by connecting the sterilant
chambers of the valves in serial fashion, forming a cascade or
chain, the cascade or chain in turn being connected at its inlet
end to a supply of fresh sterilant and at its outlet end to a
chemical analyzer. By virtue of this unique combination, the
aseptic solutions in the valve sterilant chambers can be
periodically replenished and done so with a minimum of equipment,
insuring that the strength of the sterilant in the chambers is at
all times maintained at a suitable level.
In operation, periodic replenishing, or recharging, of the valve
sterilization chambers with fresh sterilant is accomplished by
activating the fresh sterilant supply, causing fresh sterilant to
be pumped into the first chamber of the cascade or chain. The fresh
sterilant entering the first chamber forces out of that chamber the
old, or stale, sterilant stored therein. This substitution of fresh
sterilant for stale sterilant propagates down the cascade or chain
until the stale solution in all chambers has been expelled or
flushed and fresh sterilant substituted in its place. Continued
pumping of fresh sterilant results in fresh solution being
introduced into the chemical analyzer from the chamber of the last
valve in the cascade or chain. When this occurs, the chemical
analyzer provides information indicating that fresh solution has
been transmitted the entire length of the chain, and that all valve
chambers have been charged with fresh aseptic solution. The
sterilant supply now terminates operation, and the fresh solutions
in the chambers remain until the next chamber recharging cycle.
The foregoing approach to recharging the sterilant chambers on a
periodic basis is particularly advantageous because it permits the
supply of fresh sterilant to utilize completely conventional
equipment. In a preferred form, the source of fresh sterilant is a
conventional liquid metering device which is connected to both a
supply of water and a supply of concentrated chemical liquid
sterilant. When recharging is required, water is automatically
mixed by the mixer with the sterilant concentrate at a
predetermined ratio, which ratio is independent of the flow rate of
the water. Thus, the sterilant recharging system of this invention
requires, in a preferred form, no equipment which is not already
commercially available.
It has been discovered that in practice certain of the valves
associated with the storage tanks are more likely to become
contaminated than other valves. For example, in a system having one
set of valves used only for admitting cleansing solution into the
tanks for cleaning purposes and a second set of valves for filling
and draining the tanks of stored material, it has been found that
the filling and draining valves are much more likely to become
contaminated than the tank cleansing valves. This is due to the
fact that the lines leading to the filling and draining valves
after a filling and/or draining operation, notwithstanding that
such a periodically flushed, contain traces of stored material
which are subject to decay, providing a potential source of
contaminant in the valve. Whereas, the cleansing valves, through
which only cleansing solution passes as it is introduced into the
tanks, are not subject to problems introduced by trace amounts of
material which is subject to decay since only cleansing solution
passes through these valves and not the material which is
stored.
It has been an objective of this invention to provide an aseptic
storage and valving system which minimizes the contamination
problem occasioned by the presence of trace amounts of stored
material in the filling and draining valves associated with the
tanks. This objective has been accomplished in accordance with
certain additional principles of this invention by locating in the
series-connected cascade of the valve sterilant chambers, at a
point which is remote from the supply of fresh sterilant, the
chambers of those valves which are more susceptible to
contamination. By ordering the sterilant chambers of the cascade in
this manner, i.e., the more contaminated ones remote from the
sterilant supply, the stale sterilant of the more contaminated
chambers, when purged from the chambers by incoming fresh
sterilant, travels through a minimum number of chambers in the
course of flushing the cascade. With the stale sterilant of the
more contaminated chambers following the shortest possible path out
of the chain, contamination of the other, less contaminated
chambers by the more highly contaminated stale sterilants is
reduced.
While the valve sterilization chambers can be maintained with a
full supply of sterilant throughout the material loading and
storage period, I have empirically determined that the present
aseptic valving system is so effective in practice that the valves
can in fact be drained of sterilant throughout the major portion of
the storage period. This is particularly advantageous not only
because it lowers the operating cost, but also because it
eliminates problems of freeze-up of the sterilizing system in
installations exposed to very low temperatures.
More particularly, I have determined that material may be
aseptically stored and maintained under aseptic conditions for
protracted periods by merely subjecting the valves to a sterilizing
action prior to the loading of the tank and during the loading
operation. Thereafter, the sterilizing system can be shut down and
the valves and system drained. The chemical sterilizing system need
be filled only in the event that a sample is to be taken or in the
event that part of the contents of a tank are to be withdrawn.
DESCRIPTION OF THE DRAWINGS
These and other objectives and advantages of the invention will
become more readily apparent from a detailed description of the
invention taken in conjunction with the drawings in which:
FIG. 1 is a perspective view of an aseptic storage and valving
system constructed in accordance with the principles of this
invention.
FIG. 2 is a front elevational view of an aseptic valve having a
chemical sterilant chamber surrounding the valve actuator.
FIG. 3 is a cross-sectional view taken along line 3--3 of FIG.
2.
FIG. 4 is a vertical cross-sectional view through a portion of an
aseptic valve, showing a selectively sealable port and cap therefor
which together form a chemical sterilant chamber.
FIG. 5 is a vertical cross-sectional view through the port of the
valve of FIG. 4, showing the port with the cap removed and a
90.degree. elbow substituted therefor to facilitate removal of a
sample of material from the storage tank with which the valve is
associated.
DESCRIPTION OF PREFERRED EMBODIMENT
A preferred embodiment of the aseptic storage and valving system of
this invention is depicted in FIG. 1. With reference to FIG. 1 the
aseptic storage and valving system is seen to include a plurality
of storage tanks 10A and 10B in which previously sterilized bulk
material, such as crushed tomatoes, is adapted to be stored under
aseptic conditions. The storage tanks 10A and 10B can be of any
suitable size and shape, and fabricated from any suitable material.
Preferably the storage tanks 10A and 10B have cylindrical side
sections 11A and 11B closed at the bottom with conical, or
funnel-shaped, bottom sections 12A and 12B and at the top with
domed sections 13A and 13B which are provided with selectively
removable flanged manhole covers 14A and 14B. The funnel-shaped
bottom sections 12A and 12B facilitate removal of stored material
from the tanks 10A and 10B by gravity action. The flanged manhole
covers 14A and 14B permit maintenance personnel to enter the
interior of the tanks for maintenance purposes. The tanks 10A and
10B preferably are fabricated of welded steel sections to which is
secured on the inside surfaces thereof a protective lining of
glass, plastic, or the like. Such lined steel tanks are
commercially available from a number of sources including The
Bishopric Products Company, Cincinnati, Ohio. While only two tanks
10A and 10B are shown in FIG. 1, it is to be understood that any
number of tanks can be used.
The tanks 10A and 10B are provided with cleansing ports 15A and 15B
through which liquid cleansing solution can be introduced for
cleaning and flushing the interior of the tanks when free of stored
material. Conduits, or pipes, 16A and 16B, which are connected at
one end to the cleansing ports 15A and 15B, are also provided to
facilitate cleansing of the tank interiors. Aseptic valves 17A and
17B, to be described in detail hereafter, control the flow of
cleansing solution to the interior of the tanks 10A, 10B via the
pipes 16A and 16B. Valves 17A and 17B have outlet ports 18A and 18B
connected to the conduits 16A and 16B and inlet ports 19A and 19B
which are selectively connectable to a source of cleansing solution
(not shown). The ports 18A and 19A of valve 17A and ports 18B and
19B of valve 17B can be selectively interconnected to permit the
flow of cleansing solution from a supply (not shown) to the
interiors of tanks 10A and 10B via pipes 16A and 16B by movement of
respective valve actuators 9A and 9B from an inner, closed
position, to an outer, open position, in a manner to become
apparent hereafter.
The tanks 10A and 10B are each provided with inlet/outlet pipes, or
conduits, 20A and 20B through which bulk material flows when the
tanks are being filled or emptied with bulk material to be stored
or which has been stored, respectively. The inlet/outlet pipes 20A
and 20B at their upper end are connected to the lowermost portion,
or apex, of the funnel-shaped tank bottom sections 12A and 12B of
tanks 10A and 10B, and at their other ends are connected to ports
21A and 21B of aseptic valves 22A and 22B, to be described. The
valves 22A and 22B have second ports 23A and 23B, respectively,
which are always in communication, or connected, to ports 21A and
21B, respectively, regardless of whether the respective valve
actuators 8A and 8B are in outer, open or inner, closed positions.
Valves 22A and 22B have third ports 24A and 24B which can be
selectively connected to the ports 21A, 23A, 21B, 23B by movement
of valve actuators 8A and 8B from their inner, closed position to
their outer, open position.
The ports 24A and 24B of the valves 22A and 22B are provided with
selectively removable caps 38A and 38B. When the caps 38A and 38B
are secured to the ports 24A and 24B, the otherwise open ends of
the ports are closed by the caps. The caps 38A and 38B can,
however, be removed. When caps 38A and 38B are removed, a sample of
the material stored in the tanks 10A and 10B can be taken by
interconnecting the ports 24A and 21A, and the ports 24B and 21B,
by movement of their respective actuators 8A and 8B from the inner,
closed position to the outer, open position. When ports 24A and 21A
are connected, material in tank 10A flows out port 24A via pipe 20A
and port 21A. Similarly, when ports 24B and 21B are connected,
material in tank 10B flows out port 24B via pipe 20B and port
21B.
A second set of aseptic valves 30A and 30B, to the described, is
also associated with tanks 10A and 10B. The valves 30A and 30B
include port 31A and 31B which are connected via conduits, or
pipes, 32A and 32B to the ports 23A and 23B of the valves 22A and
22B. The valves 30A and 30B also include a pair of ports 33A and
34A, and 33B and 34B. The ports 33A and 34A of valve 30A, and the
ports 33B and 34B of valve 30B, are connected in series in a main
bulk material flow line 35. The ports 33A and 34A of the valve 30A
are always connected to each other to permit flow therebetween
regardless of the position of a valve actuator 36A. Similarly,
ports 33B and 34B of valve 30B are always connected for flow
therebetween regardless of the position of a valve actuator 36B.
The port 31A of valve 30C can be selectively connected to ports 33A
and 34A by movement of the valve actuator 36A from its inner,
closed position to its outer, open position. Similarly, the port
31B of the valve 30B can be selectively connected to the ports 33B
and 34B by movement of its actuator 36B from its inner, closed
position to its outer, open position.
A valve 40 is connected in the main bulk material flow line 35 at
the discharge end 35A thereof and is provided to selectively open
or close flow through the discharge end 35A of the main pipe 35. A
source of bulk material which has previously been sterilized (not
shown) is connected to the inlet end 35B of main flow line 35. The
source of sterilized bulk material (not shown) connected to inlet
end 35B of main flow line 35 may be the output of a bulk tomato
processing line of the type disclosed and claimed in the copending
application Ser. No. 40,549 of Philip E. Nelson and Glenn H.
Sullivan, entitled "Method for Processing and Storing Tomatoes,"
filed May 26, 1970, and assigned to the assignee of this invention,
which is incorporated herein by reference.
In operation, assuming previously sterilized bulk material is input
to the inlet end 35B of the main flow pipe 35 from a source (not
shown), tanks 10A and 10B are charged, or filled, by opening their
respectively associated valves 30A and 30B by moving actuators 36A
and 36B from their inner, closed position to their outer, open
position. This functions to connect port 31A to port 33A, and port
31B to port 33B, permitting bulk material to flow from the main
flow line 35 to the pipes 32A and 32B associated with the tanks 10A
and 10B. The bulk material in the pipes 32A and 32B then flows into
the tanks 10A and 10B, respectively, via lines 20A and 20B,
respectively, through ports 23A and 21A of valve 22A and ports 21B
and 23B of valve 22B, respectively, which ports are always
connected regardless of the position of their actuators 8A and 8B.
Of course, in filling the tanks 10A and 10B the ports 24A and 24B
of valves 22A and 22B must not be interconnected with ports 21A and
23A and ports 21B and 23B, respectively. This can be assured by
positioning valve actuators 8A and 8B in their inner, closed
position.
If desired, only one of the tanks 10A or 10B can be filled. If tank
10A only is to be filled, then the actuator 36A of valve 30A is
moved to its outer, open position to interconnect the ports 33A and
31A, allowing flow from the supply pipe 35 to the pipe 32A, valve
22A and inlet/outlet pipe 20A. The actuator 36B of valve 30B is
left in its inner, closed position when filling only tank 10A. This
disconnects ports 31B and 33B to prevent the flow of material from
the main flow line 35 to the tank 10B via the pipe 32B, valve 22B
and inlet/outlet pipe 20B. In a similar manner the tank 10B can be
filled without filling tank 10A.
To insure that the material stored in the tanks 10A and 10B, and
which has previously been sterilized, is maintained in a sterile
condition, the valves 17A and 17B, 22A and 22B, and 30A and 30B are
provided with aseptic devices 50A and 50B, 51A and 51B, and 52A and
52B, respectively, which are described in detail hereafter. It is
sufficient at this point to note that aseptic devices 50A and 50B,
51A and 51B, and 52A and 52B include chambers surrounding their
respectively associated valve actuators 9A and 9B, 8A and 8B, and
36A and 36B which contain chemical sterilant for establishing a
sterile zone or barrier around the actuators for preventing the
entry of contaminants into the tanks 10A and 10B via the bores in
the valves in which the actuators move. Since the chemical
sterilant in the chambers of aseptic valve devices 50A and 50B, 51A
and 51B, and 52A and 52B has a tendency to become stale, i.e., to
lose its sterilizing capability due to chemical decomposition after
a predetermined length of time, a sterilant chamber recharging
system is provided. This system includes a source of fresh chemical
sterilant 53, a sterilant supply line 54 to which the sterilant
chambers are connected, and a sterilant analyzer 55. Collectively
the interconnected sterilant supply 53, supply line 54, and
analyzer 55 function to periodically flush the stale sterilant from
the sterilant chambers and replenish them with fresh sterilant.
To insure that contaminants do not enter the tanks 10A and 10B via
the sample ports 24A and 24B of valves 22A and 22B, the chambers
defined by the ports 24A and 24B when sealed with the caps 38A and
38B, are also filled with chemical sterilant and connected in the
sterilant supply line 54 for periodic flushing of stale sterilant
and replenishment with fresh sterilant from the fresh sterilant
supply 53.
With reference to FIGS. 2 and 3, an aseptic valve 60 is shown in
solid lines which is identical to valves 17A and 17B. The valve 60,
which is shown in solid lines, when provided with a port 61 (shown
in phantom lines) is then identical to valves 22A, 22B, 30A and
30B. In describing the valve 60 of FIGS. 2 and 3, parenthetical
reference numerals are provided to identify corresponding elements
of the valves 17A, 17B, 22A, 22B, 30A and 30B shown in FIG. 1.
The valve 60 includes a valve body having detachable body sections
63, 64 and 65 which are coaxially connected together to form a
unitary valve structure by circular clamps 66 and 67. Clamps 66 and
67 function to urge together circular flanges 68 and 69 of valve
body sections 63 and 64 and flanges 70 and 71 of valve body
sections 64 and 65. A gasket 72 seals the mating surfaces of
circular flanges 68 and 69 when clamped together by clamp 66. A
gasket 73 seals the mating surfaces of the valve body sections 64
and 65 when clamped by clamp 67.
The valve body member 63 is provided with a cavity 75.
Communicating with the cavity 75 is a port 76, a port 77, and the
optional port 61, the latter port being omitted in valves 17A and
17B and included in valves 22A, 22B, 30A and 30B. Positioned within
the cavity 75 is a valve sealing member 78 which is selectively
movable to an inner, closed position shown in phantom lines in FIG.
3 to terminate communication between the port 76 and the cavity 75
and, hence, between the port 76 and the port 77 and the optional
port 61. The valve sealing member 78 is also selectively movable to
an outer, open position shown in solid lines in FIG. 3 to connect
the port 76 and the chamber 75, and hence to connect the port 76 to
the port 77 and the optional port 61. Regardless of whether the
valve sealing member 78 is in its inner, or sealed, position shown
in phantom lines or its outer, or open, position shown in solid
lines, the port 77 and the optional port 71 always communicate with
the cavity 75. Hence, if the optional port 61 is provided, the
ports 61 and 77 are always in communication with each other to
enable flow therebetween regardless of the position of the valve
sealing member 78.
To facilitate movement of the valve sealing member 78 between its
inner, closed position shown in phantom lines and its outer, open
position shown in solid lines, an actuating stem 80 is provided.
The actuating stem 80 is fixedly connected at its inner end to the
valve sealing member 78. The central section of the valve stem 80
is fitted in a circular bore 81 formed in the valve body section 64
and in a circular bore 82 formed in the valve body section 65. The
fit between the valve stem 80 and the bores 81 and 82 of the valve
body sections 64 and 65 is such as to permit the valve stem 80 to
slide and rotate within the bores 80 and 81.
To facilitate translation of the valve stem 80 between its inner,
closed position shown in phantom lines and its outer, open position
shown in solid lines, an actuating handle 85 is provided. The
actuating handle 85 is in the form of a hollow tube which at its
inner end 86 threadably engages external threads 87 provided on the
axially projecting section of the valve body member 65. The
actuating handle 85 is provided at its outer end with a cap 88
having an axial bore 89 therethrough which receives a stepped-down
diameter section 90 of the actuating stem 80. A shoulder 91 on the
actuating stem 80 engages the cap end 88 of the handle 85, enabling
the actuating stem 80 and, hence, the valve seal member 78 to be
moved from the outer, open position shown in solid lines to the
inner, closed position shown in phantom lines when the handle 85 is
rotated to translate it to the left as viewed in FIG. 3. A
transverse pin 93 passing through a cross bore in the stepped-down
diameter section 90 of the actuating stem 80 and projecting
radially beyond the stepped-down diameter section 90, engages the
outer end 88 of the handle member 85 to facilitate movement of the
actuator stem 80 and, hence, of the valve seal member 78 from its
inner, closed position shown in phantom lines to its outer, open
position shown in solid lines when the handle 85 is rotated to
translate it to its outer or right position shown in FIG. 3.
The central valve body member 64 is provided with a chamber 95
which completely encircles a portion of the actuator stem 80 at a
point intermediate its inner and outer ends. The chamber 95 is
adapted to contain chemical sterilant for the purpose of
establishing a sterile barrier or zone circumscribing the stem 80
to prevent the influx of contaminants to the cavity 75 and, hence,
to the stored material in the tank with which the valve is
associated, via the bores 82 and 81 in valve body members 65 and 64
in which the valve stem 80 translates in the course of moving
between its inner, closed and outer, open positions shown in
phantom and solid lines.
To seal the actuator stem 80 relative to the bores 81 and 82 formed
in the valve body members 64 and 65, O-rings 97 and 98 located in
circular grooves 99 and 100 formed in the stem are provided. The
groove 99 and O-ring 97 are located on the stem 80 at a point such
that the O-ring 97 always remains in the bore 81 intermediate the
ends 101 and 102 thereof, regardless of whether the valve stem is
(a) in its outer position wherein the O-ring 97 is in proximity to
the end 102 of bore 81 as shown in solid lines, or (b) in its inner
position wherein the O-ring 97 is proximate the end 101 of the bore
81 as shown in phantom lines. The groove 100, and hence the O-ring
98, is axially located relative to the stem 80 such that the O-ring
98 remains in the bore 82 between its ends 105 and 106, regardless
of whether the valve stem 80 is (a) in its inner position wherein
the O-ring 98 is proximate the end 105 of the bore 87 as shown in
phantom lines, or (b) in its outer position wherein the O-ring 98
is in a central position within the bore 82 as shown in solid
lines.
To prevent retraction of the stem 80 to a point such that the
O-ring 97 passes out of the bore 81 beyond the end 102 into the
sterilant chamber 95, which would destroy the seal produced by bore
81 and O-ring 97, a shoulder 108 is formed on the inner end of the
stem 80. The shoulder 108 abuts the inner, left-hand face 101 of
the valve body member 64 to prevent and limit movement of the
O-ring 97 beyond the solid line position shown in FIG. 3,
preventing the O-ring 97 from leaving the bore 81 and entering the
chamber 95 and thereby destroying the seal. Movement of the stem 80
inwardly to a point where O-ring 98 passes beyond the end 105 of
bore 82, which would destroy the seal between bore 82 and O-ring
98, is prevented by abutment of sealing member 78 and port 76 which
occurs when the stem is moved to its inner, closed position shown
in phantom lines.
To facilitate flushing of chemical sterilant from the chamber 95
and the replenishment thereof with fresh sterilant as is necessary
periodically since the chemical sterilant decomposes, losing its
aseptic characteristics, a sterilant inlet passage 110 and a
sterilant outlet passage 111 are provided.
The chemical sterilant inlet passage 110, if the sterilant is in
liquid form, is preferably located in the bottom of the chamber 95
while the sterilant outlet passage 111 is preferably located in the
top of the chamber. By locating the sterilant inlet and outlet
passages 110 and 111 in the bottom and top of the chamber 95, two
unobvious advantages are provided. First, the tendency of gas to be
trapped in the chamber 95 is overcome since provision of the
sterilant outlet passage 111 in the top of the chamber 95 permits
such gas to bubble out through the top of the chamber via the
sterilant outlet passage 111. With the possibility of entrapping
gas in the chamber 95 removed, the chamber 95 can be completely
filled with sterilant. Second, by locating the inlet and outlet
passages 110 and 111 in the bottom and top of the chamber 95, the
chamber 95 can be entirely filled with sterilant entering through
passage 110 before sterilant drains out of the chamber via passage
111.
Were the sterilant outlet passage 111 to be disposed horizontally,
that is, at a point 90.degree. angularly displaced about the axis
of stem 80 from the position shown in FIG. 3, it would be possible
for gas to be trapped in the upper half of the chamber 95,
preventing the chamber 95 from being completely filled with liquid
sterilant. Additionally, were the passage 111 to be disposed
horizontally, liquid sterilant entering the chamber 95 from the
inlet passage 110 would, before completely filling the chamber 95,
flow out of the chamber via the outlet passage 111, preventing the
chamber from being completely filled with sterilant.
FIG. 4 illustrates the port 76 of valve 60 sealed by a cap 115. The
cap 115 includes a tubular section 116 which at its left end 117 is
closed. The right-hand end of the tubular section 116 is provided
with a circular flange 118. The flange 118, when the cap 115 is
secured to the port 76, mates with a corresponding circular flange
120 formed on the end of the port 76, sandwiching a gasket 119
therebetween. To maintain the flanges 118 and 120 in their mating,
sealing condition, a circular clamp 114 is provided which, in the
clamped position shown in FIG. 4, urges the mating surfaces of the
flanges together to sandwich the gasket 119 therebetween. The cap
115 can be removed for unsealing the port 76 by removal of the
circular clamp 114 from the flanges 118 and 120.
When the cap 115 is secured to the valve port 76 and the valve seal
member 78 is in its inner, closed position shown in FIG. 4, a
chamber 121 is defined by the cap, port and valve seal member. To
prevent contaminants from entering the valve cavity 75, and, hence,
the storage tank with which the valve is associated, the chamber
121 is filled with chemical sterilant. To facilitate flushing of
the chamber 121 of stale sterilant and the replenishment thereof
with fresh sterilant, sterilant inlet and outlet passages 122 and
123 are provided in the bottom and top,respectively, of the cap 115
which partially defines the chamber 121. The sterilant inlet and
outlet passages 122 and 123 function with respect to the cavity 121
in a manner identical to the manner in which the inlet and outlet
passages 110 and 111 function relative to the cavity 95, i.e., to
facilitate flushing of stale sterilant and replenishment with fresh
sterilant. The inlet and outlet passages 122 and 123 are provided
at the bottom and top, respectively, of the cavity 121 for the same
reason that the inlet and outlet passages 110 and 111 are provided
in the bottom and top of the cavity 95, i.e., to prevent gas
entrapment and to prevent draining of sterilant from the cavity 121
via passage 122 before the cavity is entirely filled with
sterilant.
FIG. 5 shows the port 76 of valve 60 with the cap 115 removed
therefrom and a 90.degree. elbow 130 substituted therefor. The
elbow 130 permits a sample of the material stored in the tank with
which the valve having port 76 is associated to be conveniently
removed from the tank via the port 76 when the sealing member 78 is
moved to its outer, open position as shown in FIG. 5 wherein port
76 is connected to valve cavity 75. The 90.degree. elbow 130
includes a first open end 131 through which the sample is
discharged into a suitably positioned flask or the like container,
and an open end 132 which communicates with the outer end of the
port 76. The end 132 of the elbow 130 is provided with a circular
flange 133 and a gasket 134 which is adapted to mate with the
circular flange 120 formed on the outer end of the port 76. The
flanges 133 and 120 are maintained in engaged position, sandwiching
the gasket 134 therebetween, as shown in FIG. 5, by a circular
clamp 135.
The clamps 66, 67, 114 and 135 include a variable diameter central
circular section flanked on each side by variable diameter,
circular, diverging side sections. The diameter of the clamps 66,
67, 114 and 135 when reduced urges the mating flanges engaged by
the clamp together, and when increased permits the mating flanges
associated therewith to become separated from each other and from
the clamp.
To facilitate periodic flushing of the chambers 95 and 121 of stale
chemical sterilant, that is, of sterilant which has decomposed and
lost its aseptic qualities, and the replenishment thereof with
fresh chemical sterilant, the source of fresh sterilant 53,
sterilant supply line 54, and sterilant analyzer 55 are provided.
The supply of fresh sterilant 53, while capable of taking many
forms, preferably includes a conventional liquid mixer 140 having a
first inlet connected to a supply of pressurized sterilant carrier
141 and a second inlet connected to a supply of concentrated
chemical sterilant 142. The mixer 140, when actuated, provides to
the sterilant supply line 54 fresh chemical sterilant comprising a
mixture of (a) a carrier, and (b) concentrated sterilant at a
predetermined weight ratio. In accordance with a preferred
embodiment of this invention, the carrier is water and the
sterilant concentrate is an iodophor compound. A suitable iodophor
compound is marketed by Klenzade Products, Division of Economics
Laboratory, Inc., St. Paul, Minnesota, under the trademark
MIKRO-KLENE and includes the following compounds by weight:
Active butoxpolyprotoxy, polyethoxy, ethanol-iodine complex,
providing 1.75% titratable iodine 15.5% Phosphoric acid 6.5% Inner
liquid carrier 78.0%
When a chemical sterilant concentrate is used of the type set forth
above, the sterilant concentrate is mixed with the carrier, which
preferably is water, at a ratio by weight of 20-25 parts of iodine
per million parts of water.
The mixer 140 can take any form and preferably is of the type
commercially available from Economics Laboratory, Inc., St. Paul,
Minn., marketed under the name Micro-Master, Model 5C63.
To facilitate the simple and efficient flushing of the chambers 121
and 95 of stale sterilant and the replenishment thereof with fresh
sterilant from the supply 53, the sterilant chambers 95 and 121 of
the valves 60 are connected in series in the sterilant supply line
54 to form a chain or cascade of sterilant chambers. Specifically,
the sterilant chambers 50A, 50B, 52A, 51B, 52B, 51A, 38A-24A and
38B-24B are connected in series in the order mentioned in the
sterilant supply line 54. With the sterilant chambers so connected
in the supply line 54 to the source of fresh sterilant 53 pumped
into the inlet end 54-1 of supply line 54, the stale sterilant in
the series-connected sterilant chambers 50A, 50B, 51B, 52B, 51B,
52A, 38A-24A and 38B-24B is flushed from the chambers and the
supply of sterilant replenished with fresh sterilant, the chambers
being flushed and replenished on a sequential basis in the order
mentioned. Specifically, when the supply of fresh sterilant 53 is
first activated, fresh sterilant is pumped into the supply line
section 54-1 to the bottom of the sterilant chamber of aseptic
device 50A of valve 17A. The entry of fresh sterilant into the
bottom of the chamber 95 of aseptic device 50A via line 54-1 and
associated sterilant inlet passage 110 functions to flush out of
the top of that chamber the stale sterilant therein, forcing such
stale sterilant into sterilant supply line section 54-2 via
sterilant outlet passage 111. The stale sterilant flushed out of
the sterilant chamber 95 of aseptic device 50A of the valve 17A and
which is in sterilant supply line section 54-2, then enters the
bottom of the chamber 95 of aseptic device 50B of valve 17B via
passage 110, forcing out of the top of that chamber the stale
sterilant via outlet passage 111. This process continues until the
stale sterilant in all chambers 95 and 121 of the aseptic devices
50A, 50B, 52B, 51B, 52A, 51A, 38A-24A and 38B-24B connected in the
line 54 has been flushed and fresh sterilant from supply 53
substituted therefor.
To readily determine when all the stale sterilant has been flushed
from the chambers 95 and 121 of the aseptic devices 50A, 50B, 51A,
51B and 52A, 52B, 38A-24A and 38B-24B and fresh sterilant from the
supply 53 substituted therefor, the chemical analyzer 55 is
provided which is connected via supply line section 54-n to the
sterilant outlet passage 123 of the sterilant chamber 121 of the
last aseptic device 38B-24B in the cascade. The chemical analyzer
55 monitors the sterilant in line 54-n leaving the last sterilant
chamber 121 of device 38B and determines the sterilization
capability of the sterilant in line 54-n. When the sterilant
leaving the last sterilant chamber 121 of aseptic device 58B-24B of
the cascade or chain via line 54-n corresponds in strength, that
is, in sterilization capability, to that of the fresh sterilant
leaving the supply 53 and entering the cascade or chain via supply
line section 54-1, the sterilant supply 53 is deactivated, stopping
the flow of fresh sterilant into line 54-1. At this point the stale
sterilant in all the chambers 95 and 121 of the cascaded chain of
aseptic devices 50A, 50B, 52B, 51B, 52A, 51A, 38A-24A and 38B-24B
is deemed to have been flushed from the chain or cascade, and the
sterilant chambers of the chain or cascade replenished with fresh
sterilant from supply 53.
To remove a sample of stored material from one of the tanks 10A or
10B, cap 38A or 38B, as the case may be, is removed from the port
24A or 24B by removing the associated clamp 114. The elbow 130 is
then secured to the port 24A or 24B using the clamp 135, which
clamp in reality would preferably be the same clamp as clamp 114
which held the cap 38A or 38B secured to the port 24A or 24B. With
the elbow 130 in place and a suitable flask positioned in
communication with the elbow mouth 131, the valve actuator 8A or 8B
is moved to its outer position causing the valve sealing member 38
to unseal the port 24A or 24B. When the sample is obtained, the
valve actuator 8A or 8B is moved to its inner position to seal the
port 24A or 24B with the valve sealing member 78. The port 24A or
24B is again sealed by the cap 38A or 38B using the clamp 114. At
this point it is desirable to recharge all sterilant chambers in
the cascade, thereby returning the port 24A or 24B and associated
cap 38A or 38B which collectively define a sterilant chamber 121,
which is associated with the tank from which the sample has just
been removed, to a sterile condition.
The chemical analyzer 55, while capable of a variety of designs,
preferably is designed in accordance with the principles
incorporated in the iodine/chlorine Test Kit No. 101 marketed by
Klenzade Products, Division of Economics Laboratory, Inc., St.
Paul, Minn.
To retard the decomposition of chemical sterilant, the sterilant
supply line 54 and the aseptic devices 50A, 50B, 51A, 51B, 52A,
52B, 38A-24A and 38B-24B are preferably opaque, thereby shielding
the sterilant from sunlight which accelerates decomposition of the
sterilant, making it become stale more quickly. Additionally, the
supply line 54 and the aseptic devices 50A, 50B, 51A, 51B, 52A,
52B, 38A-24A and 38B-24B are preferably fabricated of material as
chemically inert as possible. This prevents decomposition of the
sterilant and retards corrosion by the sterilant of the tubing 54
and the aseptic devices 51A, 51B, 52A, 52B, 50A, 50B, 38A-24A and
38B-14B. A material having the desired opacity to retard
decomposition of the sterilant, and the desired inertness to resist
corrosion by the sterilant as well as decomposition of the
sterilant, is stainless steel.
The chemical sterilant, if in the form of an iodine-based liquid,
should be maintained at a temperature below 110.degree. F. above
which iodine sublimes to gas.
It has been discovered in practice that the chemical sterilant in
certain of the series connected sterilant chambers 95, 121 of
aseptic devices 50A, 50B, 51A, 51B, 52A, 52B, 38A-24A and 38B-24B
in line 54 tend to become contaminated to a greater extend than the
chemical sterilant in certain other of the sterilant chambers.
Specifically, it has been found in practice that the sterilant in
chambers 121 of the type defined by caps 38A and port 24A, and cap
38B and port 24B tends to become more contaminated than the
sterilant in chambers 95 of aseptic devices 52A, 52B, 51A and 51B
due to residues of stored material which remain in ports 24A and
24B when samples are withdrawn; and that the sterilant in chambers
95 of aseptic devices 51A, 51B, 52A and 52B tends to become more
contaminated than the sterilant in chambers 95 of aseptic devices
50A and 50B due to the fact that stored material passes through
valves 22A, 22B, 30A and 30B and not through valves 17A and 17B. In
view of this tendency of the sterilant of certain of the sterilant
chambers to become more contaminated than others, the sterilant
chambers should be connected in series in a line 54 such that the
sterilant chambers which are contaminated to a greater extend are
closer to the drain end 54-n of the sterilant supply line 54, and
the sterilant chambers which tend to become contaminated to a
lesser extent are closer to the supply of fresh sterilant 53. In
this way the sterilant of the chambers which become contaminated to
the greatest extent, i.e., chambers 121 of devices 38A-24A and
38B-24B, is not passed through the sterilant chambers of the
devices which become contaminated to a letter extent, i.e.,
chambers 95 of aseptic devices 50A, 50B, 51A, 51B, 52A and 52B,
which if allowed to occur would unnecessarily introduce
contaminants from the more contaminated sterilant chambers into the
less contaminated sterilant chambers, compounding the overall
contamination problem.
While the valves may be kept full of sterilant which is
periodically replenished throughout the entire period of storage, I
have empirically determined that in many installations this is not
required. Specifically, I have determined that a satisfactory
alternate method of operation involves the sterilization of the
valves as described above prior to the loading of the tanks. The
valves are maintained in a sterilized condition during the loading
operation with the sterilant being periodically replenished as
described above. However, after the tanks have been loaded, the
valves and sterilant system are drained. Unless, samples are to be
taken or the tank is to be partially emptied, the contents of the
tanks are maintained in an aseptic condition during the entire
period of storage without further operation of the sterilizing
system.
In the event a sample is to be taken, the sterilizing system is
charged with sterilant and operated as described above prior to and
during the period of sampling. After the sample has been taken, the
valves and sterilizing system can be shut down and drained. If all
of the material from the tank is to be removed at one time, I have
determined that is is unnecessary to recharge the sterilant system
during the withdrawal period. If, however, only a portion of the
contents of the tank are to be removed, the sterilizing system
should be operated immediately prior to the removal of material
from the tank, during the period of removal and for a brief period
immediately following removal. After this, the sterilizing system
can be shut down and drained and the remaining material in the tank
will be kept under aseptic conditions.
* * * * *