U.S. patent number 3,699,970 [Application Number 05/049,094] was granted by the patent office on 1972-10-24 for striate cortex stimulator.
This patent grant is currently assigned to National Research Development Corporation. Invention is credited to Giles Skey Brindley, Peter Eden Kirwan Donaldson.
United States Patent |
3,699,970 |
Brindley , et al. |
October 24, 1972 |
STRIATE CORTEX STIMULATOR
Abstract
An implantable neurological prosthetic device comprises a
plurality of electrodes for stimulating the striate cortex, a
matrix of normally closed gates connected in one-to-one
relationship with said electrodes, and a plurality of radio
receivers tuned to predetermined frequencies and constituting at
least two distinctive sets, each gate being connected for switching
to an open state to energize the respective one of said electrodes
by a unique group of at least two of said receivers from
respectively different sets thereof. The receivers are themselves
energizable by externally located respective transmitters
conveniently positioned by a technique in which the transmitter
tuned circuit is included as one arm in a bridge circuit balanced
for maximum absorption by the respective receiver tuned circuit.
This technique is more generally applicable to any implant provided
with a tuned circuit.
Inventors: |
Brindley; Giles Skey (London,
EN), Donaldson; Peter Eden Kirwan (Oxford,
EN) |
Assignee: |
National Research Development
Corporation (London, EN)
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Family
ID: |
10337998 |
Appl.
No.: |
05/049,094 |
Filed: |
June 23, 1970 |
Foreign Application Priority Data
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Jun 26, 1969 [GB] |
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32,398/69 |
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Current U.S.
Class: |
607/54; 324/652;
607/60; 607/66; 607/61; 324/636; 324/692 |
Current CPC
Class: |
A61N
1/36046 (20130101) |
Current International
Class: |
A61N
1/36 (20060101); A61n 001/18 () |
Field of
Search: |
;3/1
;128/404,410,419P,419R ;340/407 ;324/101,57Q,57B ;343/703 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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575,075 |
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Apr 1924 |
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FR |
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1,910,972 |
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Oct 1969 |
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DT |
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Primary Examiner: Kamm; William E.
Claims
We claim:
1. An implantable device comprising a plurality of electrodes for
stimulating the striate cortex, a matrix of normally closed gates
connected in one-to-one relationship with said electrodes, and a
plurality of radio receivers tuned to predetermined frequencies and
constituting at least two distinctive sets, each gate being
connected for switching to an open state to energize the respective
one of said electrodes by a unique group of at least two of said
receivers from respectively different sets thereof.
2. A device according to claim 1 wherein adjacent receivers in at
least one set thereof are tuned to respectively different
frequencies.
3. A device according to claim 1 wherein each of said gates
comprises a semi-conductor switching device connected in the common
emitter configuration.
4. A device according to claim 1 in combination with a plurality of
radio transmitters respectively associated with and tuned to common
frequencies with said receivers in a one-to-one relationship, at
least one set of said transmitters being energizable at a
predetermined constant level, and the transmitters of at least one
other set thereof being energizable at adjustable power levels.
5. A device according to claim 1, in combination with a bridge
circuit having a tuned circuit in one arm thereof adapted to match
that of one of said receivers, and means for indicating the degree
of balance of said bridge circuit.
6. A device according to claim 1 wherein said gates and said
receivers are encapsulated in an anatomically shaped mold of
silicone rubber.
7. In combination,
an implantable device including a plurality of electrodes for
stimulating the striate cortex, a matrix of normally closed gates
connected in one-to-one relationship with said electrodes, and a
plurality of radio receivers tuned to predetermined frequencies and
constituting at least two distinctive sets, each gate being
connected for switching to an open state to energize the respective
one of said electrodes by a unique group of at least two of said
receivers from respectively different sets thereof, and
an exterior mounted device including a plurality of radio
transmitters respectively associated with and tuned to common
frequencies with said receivers in a one-to-one relationship, at
least one set of said transmitters being energizable at a
predetermined constant level, and the transmitters of at least one
other set thereof being energizable at adjustable power levels, and
means for mounting said exterior device on a body adjacent said
implantable device.
8. In combination,
an implantable device comprising a plurality of electrodes for
stimulating the striate cortex, a matrix of normally closed gates
connected in one-to-one relationship with said electrodes, a
plurality of radio receivers tuned to predetermined frequencies and
constituting at least two distinctive sets, means for energizing
said received each gate being connected for switching to an open
state to energize the respective one of said electrodes by a unique
group of at least two of said receivers from respectively different
sets thereof, and
an exterior device including a bridge circuit having a tuned
circuit in one arm thereof for matching one of said receivers, and
means for indicating the degree of balance of said bridge circuit.
Description
Consideration has been given to the possibility of producing a
prosthesis which will afford electrical stimulation of the striate
cortex and give useful visual sensations to patients who have lost
the use of their eyes. Initial work to this end has proved
promising. Briefly, this work involved the implantation of an array
of radio-driven stimulators. The implant comprised an intracranial
part and an extracranial part. The intracranial part had the form
of a cap of silicone rubber, molded to fit the calcarine and
neighboring cortex of the right hemisphere, and bearing a plurality
of platinum electrodes. The electrodes were joined in a one-to-one
relationship by a cable to the extracranial part which comprised an
array of radio receivers between the parieto-occipital skull and
pericranium. Delivery of a train of short pulses of radio waves to
one of the receivers resulted in the patient "seeing " a small spot
of white light, or phosphene, while simultaneous delivery to a
number of receivers produced a pattern of phosphenes. In practice,
it was proposed that delivery to such a device be affected by a
corresponding array of radio transmitters housed in a cap or hat
for the patient.
Various aspects of the above work are discussed in more detail in
articles entitled "Transmission of electrical stimuli along many
independent channels through a fairly small area of intact skin" by
G.S. Brindley (J. Physiol. 177, 44-46P), "The visual sensations
produced by electrical stimulation of the medical occipital cortex"
by G.S. Brindley and W.S. Lewin (J. Physiol. 194, 54-55P), and "The
sensations produced by electrical stimulation of the visual cortex"
by G.S. Brindley and W.S. Lewin (J. Physiol. 196, pp.479-493).
Clearly a useful endeavor of this kind will involve a large number
of stimulating electrodes, and corresponding numbers of receivers
and transmitters.
According to the present invention in one aspect, the number of
receivers in such a device, and by the same token the number of
associated transmitters also, is reduced by employing a selection
matrix arrangement for controlling the energization of the
electrodes. Thus, a matrix of gate circuits is provided for
connection to the stimulating electrodes, each gate being
controlled by a unique group of receivers, one each from at least
two sets of receivers connected with the matrix of gates in
respectively different co-ordinate senses.
Selection matrix arrangements are in fact known in other
applications and it is usual to talk of rows and columns in the
matrix since the matrix is normally thought of as a
two-dimensional, rectangular one with Cartesian coordinates.
Reference is accordingly made hereinafter to rows and columns, but
it is to be understood that this is for convenience only since the
physical lay-out need not be rectangular and there can be more than
two dimensions.
In any event, a clearer understanding of this aspect of the
invention will be gathered from the following consideration of the
accompanying drawings which are given by way of example, and in
which:
FIG. 1 illustrates the circuit, partly schematically, of one
embodiment of the invention, and
FIG. 2 similarly illustrates a further circuit ancillary to that of
FIG. 1.
In FIG. 1, three row conductors R1, R2, R3 and three column
conductors CL1, CL2, and CL3 are shown affording control of nine
gates by way of six receivers. Three of the receivers RR1, RR2, RR3
are respectively connected to the row conductors R1, R2, R3 and the
other three receivers RC1, RC2, RC3 are respectively connected to
the column conductors CL1, CL2, and CL3. Gate G11 is connected to
row conductor R1 and column conductor CL1, gate G12 is connected to
row conductor R1 and column conductor CL2, and so on to gate G33
connected to row conductor R3 and column conductor CL3. Each gate
is connected to a different one of nine stimulating electrodes
denoted as terminals E11, E12, . . . . E33, and each electrode is
energized by sending a radio signal to the row and column receivers
to which the associated gate is connected. This energization is
such that the row receiver connects the base of the gate transistor
T1 to earth, while the column receiver lowers the emitter potential
of that transistor, and so the gate is rendered conductive against
the base electrode bias B which normally holds all of the gates
non-conductive.
In operation of the device to produce a pattern of phosphenes, it
is necessary that the gates be controlled by a scanning action. For
example, if only gates G11 and G22 are to be activated, receivers
RR1 and RC1 and receivers RR2 and RC2 are involved, but
simultaneous energization of these four receivers will also
activate gates G12 and G21. Accordingly, the row receivers are
energized on a sequential basis and the column receivers for any
gates to be activated in a given row are selectively energized
simultaneously with the receiver for that row. This may appear to
be a practical disadvantage consequent upon the use of a selection
matrix arrangement, but it is in fact fully compatible with the
normal visual processes. Indeed, there is practical advantage in
that compensation can be made for the different threshold
energization appropriate to stimulation with different ones of the
electrodes. Thus, the row receivers can be scanned with
energization at a predetermined level, while the column receivers
are selectively energized at variable levels. Alternatively,
variation of column receiver duration of energization can be
employed in place of power level.
This mode of operation is indicated schematically in the drawing by
the row transmitters TR1, TR2, TR3 and column transmitters TC1,
TC2, TC3 which are tuned to match their respective receivers RR1,
RR2, RR3 and RC1, RC2, RC3, and are respectively energizable from
power sources PR and PC by way of selector switches SR and SC. It
will be noted that the power source for the column transmitters is
denoted as variable by an arrow, this denoting variability of
transmitted pulse power level or duration.
In connection with production of patterns rather than "single"
phosphenes, it is desirable, particularly where different
energization levels are to be involved, that adjacent column
receivers be tuned to mutually different frequencies to avoid any
cross-talk, and these frequencies should also differ from that, or
those, of the row receivers.
In this same connection, it is to be understood that the primary
input pattern can be derived from a television camera tube or other
suitable form of sensor, the output of which is translated to
appropriate signal form for energization of the transmitters to
stimulate a corresponding pattern in the recipient. In general, the
transmitters will normally energize the row receivers in sequence,
each for a period during which any relevant associated column
receivers are also energized, so giving a column scanning action
within each phase of a row scanning action.
While various circuit arrangements may be employed for the
receivers of the presently proposed device, and also for the
associated receivers, the illustrated common emitter configuration
is preferred for the gates.
For completeness, the component values of the illustrated example
are as follows:
C1 = 1.mu.F C2 = 100pF C3 = 1000pF C4 = 150pF C5 = 10000pF R1 =
8k.OMEGA.Transistors T1 currently have Vceo .gtoreq. 60V.
Diodes D1 are currently chosen with p.i.v. .gtoreq. 60V.
Zener diodes Z are 55V, that is, less than Vceo of T1.
The tuned circuit coils are all wound from common material to 1 cm.
diameter. Coils I1 for the rows are each wound to twelve turns and
tapped at two turns for a frequency of 10 Mc/s. Coils I2 and I3 are
used in alternating sequence along the columns, I2 being wound to
thirteen turns and tapped at ten turns for a frequency of 8 Mc/s,
and I3 being wound to seventeen turns and tapped at ten turns for a
frequency of 6 Mc/s.
Turning to another aspect of the present invention: difficulty may
arise in attaining the desired location of the transmitters
relative to the receivers since the latter are implanted while the
former are employed externally of the subject. The difficulty is
not exclusive to the above-proposed visual prosthetic device, but
it clearly becomes more significant when a number of inductive
links are to be established within a small area. It might also be
mentioned that this difficulty is not readily resolved by
attempting to mark on a patient's exterior the locations of the
implanted receivers.
A technique for obviating this difficulty has been evolved in the
course of the present work, which technique derives from the fact
that the implant or implant item to be located in the present
instance includes a tuned circuit, and there is a corresponding
external tuned circuit in the associated transmitter. Location is
achieved by connecting the external tuned circuit in a bridge
circuit including a meter and arranged for balance when a
corresponding tuned circuit is immediately adjacent that of the
bridge. Thus, the bridge is balanced for maximum absorption from
its tuned circuit and it can be used to locate the corresponding
tuned circuit of an implant by watching the meter while scanning
the patient with the tuned circuit.
This technique is naturally suitable when, as here, the tuned
circuits are to be provided anyway, and this is indicated in FIG. 2
by the bridge circuit B in which the voltage to one side of the
meter M is derived from the tuned circuit of the relevant
transmitter.
The results with this technique have been found so satisfactory
that tuned circuits, or an adjustable tuned circuit, might be
provided specifically for the purposes of receiver location. Indeed
the technique can be employed more generally in the location of
implanted devices, and an absorption or rejection mode may be
employed.
Accordingly, the present invention provides, in a second aspect,
apparatus for locating an implant including a tuned circuit, the
apparatus comprising a bridge circuit including a corresponding
tuned circuit as one arm of the bridge, and means for indicating
the degree of balance of the bridge. The indicating means need not
necessarily be of visual form, such as a meter, but may
alternatively, or in addition, be of audible form whereby a
variable tone is generated in dependence upon the degree of bridge
balance.
Yet another aspect of the present invention involves the
manufacture, and in particular the molding and encapsulation of
implantable prosthetic devices. It is usual to encapsulate such
devices with a silicone rubber material which is conventionally
available as a paste in a tube. However, this form of material has
not been found fully satisfactory in a situation such as that for
the above form of device where the encapsulating material can also
serve as a mold material to be formed to a required shape in which
other components are carried. The necessary molding will often, as
here, be best carried out by casting and a paste is clearly not
suitable. Also, the usual paste material is only self-adhesive and
not suitable for encapsulating complex physical shapes, such as an
array of electrodes. Lastly, the usual paste material is somewhat
hard when cured for the present purpose.
These difficulties have been reduced in accordance with the
invention in its last-mentioned aspect, by mixing a medical
silicone rubber adhesive of paste form with a solvent to form a
liquid adhesive, and adding an inert filler. Initially, the
adhesive paste was simply mixed with the solvent, but this was
found to be too thin and to leave cavities and voids after pouring
and curing with consequent trapping of air and water. This is
undesirable as a cause of electrical failure, and the filler is
included to reduce this problem. As to the constituent proportions:
these can be varied dependent on the hardness or softness of cured
rubber required. However, it is useful to specify the constituents
of the product found generally satisfactory for the above purposes,
namely, Dow Corning Medical Adhesive Type A, Dow Corning Medical
Fluid 360 and xylene in the respective proportions of nine inches,
5 c.c. and 10 c.c. This resultant adhesive does not shrink,
distort, or absorb water.
* * * * *