U.S. patent number 3,699,947 [Application Number 05/162,165] was granted by the patent office on 1972-10-24 for electroencephalograph monitoring apparatus.
This patent grant is currently assigned to National Research Development Corporation. Invention is credited to Douglas Edward Maynard.
United States Patent |
3,699,947 |
Maynard |
October 24, 1972 |
**Please see images for:
( Certificate of Correction ) ** |
ELECTROENCEPHALOGRAPH MONITORING APPARATUS
Abstract
Monitoring equipment is provided for monitoring electrical
signals in the human brain. Signals from electrodes attached to the
scalp are passed to a bandpass filter where certain interference
signals, such as those arising from muscle action and rapid
psycho-galvanic responses, are removed. The filter also applies a
weighting to equalize the effect of random brain activity over the
filter band, and to allow rhythmic activity to be more clearly
observed. A logarithmic amplifier is connected to the filter output
to provide amplitude compression signals received from the brain.
The impedance between the electrodes is monitored to give an
indication if the electrodes become wholly or partially
disconnected.
Inventors: |
Maynard; Douglas Edward (Stoke
Poges, EN) |
Assignee: |
National Research Development
Corporation (London, EN)
|
Family
ID: |
22584434 |
Appl.
No.: |
05/162,165 |
Filed: |
July 13, 1971 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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771192 |
Oct 28, 1968 |
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Current U.S.
Class: |
600/544;
600/547 |
Current CPC
Class: |
A61B
5/30 (20210101) |
Current International
Class: |
A61B
5/04 (20060101); A61b 005/04 () |
Field of
Search: |
;128/2.1B,2.1R,2.1Z,2.06 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Howell; Kyle L.
Parent Case Text
This application is a continuation-in-part of Ser. No. 771,192,
filed Oct. 28, 1968, now abandoned.
Claims
I claim:
1. Apparatus for monitoring electric signals in the human brain,
comprising:
a pair of electrodes adapted to be fixed to the scalp,
filter means coupled to said electrodes, having a frequency versus
loss characteristic in which loss decreases with increasing
frequency so as to, in operation, substantially equalize the
amplitude of the filter output signals due to random electrical
activity of the brain, the said decrease in loss with increase in
frequency being from a low frequency designated the lower
predetermined frequency, to a high frequency designated the upper
predetermined frequency, the upper and lower predetermined
frequencies being below 30 c/s and above 0.3 c/s, respectively, and
loss below the lower predetermined frequency, and above the upper
predetermined frequency, being greater than the loss at the lower
and upper predetermined frequencies, respectively,
amplifying means for amplifying signals which pass through said
filter means, and indicator means for indicating the magnitude of
signals from said amplifying means.
2. Apparatus according to claim 1, wherein
the said filter means has a characteristic, plotted as the
logarithm of frequency against loss in decibels, such that said
decrease in loss with increase in frequency is at a generally
constant rate providing a loss decrease of between 4 and 12
decibels over the range 3 to 12 c/s.
3. Apparatus according to claim 1, wherein
said lower predetermined frequency of said filter means is
substantially 2 c/s.
4. Apparatus according to claim 1, wherein
said lower predetermined frequency of said filter means can be
varied from 2 to 12 c/s.
5. Apparatus according to claim 1, wherein
said upper predetermined frequency of said filter means is
substantially 15 c/s.
6. Apparatus according to claim 1, wherein
said upper predetermined frequency of said filter means can be
varied from 8 to 20 c/s.
7. Apparatus according to claim 1, comprising
low-noise amplifier means coupled between said electrodes and said
filter means.
8. Apparatus according to claim 1, wherein
said amplifying means includes a logarithmic amplifier.
9. Apparatus according to claim 1, wherein said indicating means
includes
a detector circuit coupled to said amplifying means and a recorder
coupled to said detector means having a pen to mark a recording
medium, said recorder being adapted to provide a visible record
whose intensity at a point depends on the number of times said pen
traverses said point.
10. Apparatus according to claim 1, including monitoring means for
monitoring the impedance between said electrodes, comprising
reactive means coupled between said electrodes,
oscillator means coupled across said reactive means and a further
impedance,
phase-comparison means for determining the phase relationship of
two signals in the monitoring means to provide an output signal,
dependent on the phase relationship of the said signals, giving an
indication of change in impedance between said electrodes, and
indicating means, for indicating said change of phase relationship,
coupled to the output of said phase comparison means.
11. Apparatus according to claim 10 wherein
said reactive means is a capacitor and the further impedance is a
resistor.
12. Apparatus according to claim 11 wherein the capacitor is
coupled in series with the resistor across the output of the
oscillator and the phase comparison means compares the oscillator
output voltage with the voltage across the capacitor.
13. Apparatus according to claim 12 wherein said phase comparison
means includes
first and second means for forming square-waves from said signals
from said oscillator and across said reactive means, respectively,
and
And gate means adapted to receive said square-wave signals as
inputs, the time during which said AND gate means is open providing
said indication of said phase relationship.
14. Apparatus according to claim 13, wherein
said AND gate is constructed to become permanently in one state if
there is no path for signals from said oscillator by way of said
reactive means.
15. Apparatus according to claim 10, wherein
the frequency of said oscillator is above the upper predetermined
frequency of said filter means,
said oscillator is coupled to said electrodes between said
electrodes and said filter;
said reactive means is coupled to the input of said filter, and
frequency-selective means is provided which is adapted to reject
all frequencies present at the input to said filter except that of
said oscillator, the input of said frequency selective means being
coupled in parallel with the input of said filter, and the output
of said frequency selective means is coupled to said phase
comparison means.
16. Apparatus for monitoring electrical electrical signals in the
human brain, comprising:
a pair of electrodes adapted to be fixed to the scalp,
filter means coupled to said electrodes, having a frequency versus
loss characteristic in which loss decreases with increasing
frequency at a generally constant rate providing a loss decrease of
between 4 and 12 decibels over the range 3 to 12 c/s, and loss
increases with decrease in frequency below, and with increase in
frequency above, the said range at a greater rate than the said
rate, amplifying means for amplifying signals which pass through
said filter means, and indicator means for indicating the magnitude
of signals from said amplifying means.
Description
The present invention relates to apparatus for monitoring
electrical signals in the human brain and to apparatus for
monitoring the impedance of electrodes attached to the body and
used particularly, but not exclusively, in the signal-monitoring
apparatus.
In some circumstances, such as recovery from prolonged cardiac
arrest, changes in the electroencephalogram (EEG) over a period of
hours to a few days are important. Continuous EEG recording is not
practical since it is excessively costly, so EEG sampling by
multi-channel recorders is used. It has been shown that the
sampling techniques are inadequate in assessing a patient's state
and can sometimes give misleading results.
The present invention springs from the realization that the EEG
shows two main forms of activity: so-called random activity whose
amplitude falls with frequency, and rhythmic activity which is
partly spread over the same band as the random activity and partly
takes the form of sinusoidal signals of widely fluctuating
amplitudes, those of greatest amplitude usually occurring in the
range 8 to 12 cycles per second (c/s).
According to the present invention there is provided apparatus for
monitoring electrical signals in the human brain, comprising a pair
of electrodes, adapted to be fixed to the scalp, coupled to a
filter of the type hereinafter specified in which the lower
predetermined frequency is above 0.3 c/s and the upper
predetermined frequency is below 30 c/s, respectively, and in which
the frequency versus loss characteristic falls with increase in
frequency between the lower and upper predetermined frequencies, so
as to in operation substantially equalize the amplitude of filter
output signals due to random electrical activity of the brain,
means for amplifying signals which pass through the filter, and
indicator means for indicating the amplitude of signals from said
amplifier means.
In this specification a filter of the type specified has a
frequency versus loss characteristic (that is the logarithm of
frequency plotted against loss in decibels) in which loss decreases
with increase in frequency at a generally constant rate from a low
frequency to a high frequency designated as the lower predetermined
frequency and the upper predetermined frequency, respectively. As
frequency falls below the lower predetermined frequency, or rises
above the upper predetermined frequency, loss increases at a rate
greater than the said generally constant rate.
The importance of the frequency versus loss characteristic of the
filter will now be appreciated; that is all frequency components of
the random activity falling within the passband of the filter are
equally represented, and the sinusoidal signals are prominent in
the output instead of being swamped by the low-frequency random
activity.
Preferably the apparatus includes a detector and a recorder and/or
meter.
By using the filter the trace provided by the recorder is converted
from a form in which little information of a useful character can
be obtained to one in which changes in the activity of the brain
can readily be observed, especially relatively long term changes
occurring in times of for example half an hour. Such changes are
difficult or impossible to observe on conventional EEG devices and
often give considerable warning, of for example an hour, of cardiac
arrest, an instant indication that all is not well during surgical
operations, and where resuscitation is being attempted an
indication that success will be achieved many hours before any
other signs of return to consciousness are seen.
The output from this apparatus being in a simple form, can to a
large extent be interpreted by medical and nursing staff who have
had experience of the apparatus. A far clearer indication of trends
is obtained than from successive EEG recordings, and it is believed
that operation could be carried out by relatively unskilled
staff.
Since the apparatus is inexpensive, continuous monitoring is
practicable and when used in conjunction with occasional EEG
samples on a multi-channel recorder gives almost as much relevant
information as would be obtained by continuous EEG recording.
The frequency versus loss characteristic of the filter preferably
falls at a generally constant rate which provides a loss decrease
of between 4 and 12 db over the range 3 to 12 c/s.
Although in some circumstances it may be convenient if the filter
has the frequency range mentioned above, the upper predetermined
frequency of the filter is preferably variable from 15 c/s to 5 c/s
and the lower predetermined frequency is variable from 2 c/s to 12
c/s.
The electrodes are preferably coupled to the filter by way of a low
noise amplifier which may be a parametric amplifier, and the output
from the filter is amplified by a logarithmic or semi-logarithmic
amplifier in order to compress the amplitude of the output
signal.
The impedance associated with electrodes attached to the body tends
to be subject to changes and, of course, the electrodes may become
completely disconnected. This is a weakness of the apparatus,
although the parametric amplifier can be designed to give only a 1
percent error in gain when the electrode impedance has risen to
about 80 Kilohms. At such impedance however the apparatus becomes
more sensitive to interference.
According to another aspect of the present invention therefore
there is provided apparatus for monitoring impedance between
electrodes comprising a reactive component coupled between a pair
of electrodes, each electrode being suitable for attachment to the
human body, and the reactive component being coupled with a further
impedance across the output of an oscillator, and phase comparison
means for comparing the phase of two signals in the apparatus to
provide an output signal dependent on the phase relationship of the
said signals, the apparatus being such that if, when the electrodes
are attached to a human body, the impedance between the body and
the electrodes changes, then a change in the said phase
relationship is indicated by the output signal of the phase
comparison means.
The reactive component is preferably a capacitor and the further
impedance a resistor. The electrodes may, of course, be those of
the signal-monitoring apparatus, if the oscillator frequency is
outside the passband of the filter.
Certain embodiments of the invention will now be described by way
of example with reference to the accompanying drawings in
which:
FIG. 1 is a block diagram of apparatus according to one aspect of
the invention for monitoring electrical signals in the human
brain;
FIG. 2 is a graph showing variation of electrical brain activity
with frequency;
FIG. 3 is a graph showing output signals from the filter 14 of FIG.
1;
FIG. 4 is a block diagram of apparatus according to another aspect
of the invention for monitoring the impedance associated with
electrodes attached to the body;
FIG. 5 is a circuit diagram of the apparatus according to FIG. 4
which also shows, partly be means of a block diagram, how the two
monitors can be combined;
FIG. 6 shows the loss versus frequency characteristic of the filter
of FIG. 1;
FIGS. 7 and 8 show the output from the recorder of FIG. 1 in
different circumstances;
FIG. 9 is a part-circuit part-block diagram of the filter 14 and
the amplifier 15 of FIG. 1; and
FIG. 10 is a loss versus frequency characteristic used in
explaining the setting up of the filter 14.
In FIG. 1 two silver-disc electrodes 10 and 11 are, in use,
attached to the scalp to pick up electrical signals in the brain.
The electrodes are coupled by way of fully screened cables whose
characteristics do not vary with vibration i.e. the cables are
non-microphonic) to a low pass filter 12 which acts as a
radio-frequency trap preventing high frequency interference
reaching a low-noise parametric amplifier 13. A special filter 14
which has the weighted loss versus frequency characteristic shown
in FIG. 6, is coupled to the output of the amplifier 13. Signals
from the filter are amplified first by a logarithmic amplifier 15
which provides amplitude compression, and then by an amplifier 16.
A detector 17 provides a signal for a meter 18 and a recorder 19,
from the output of the amplifier 16.
The Isleworth Electronics pre-amplifier A101 is suitable as the
parametric amplifier 13, especially if specified as having selected
low noise input transistors, but many low noise differential
amplifiers are suitable such as the Burr Brown instrumentation
amplifiers nos. 3161/25 and 3061/25.
The loss versus frequency characteristic of the filter 14 which is
one of the most important features of the invention will now be
described, and then the construction of filters with this
characteristic will be discussed.
As can be seen from FIG. 6, to reduce the effect of interference of
originating from muscle action potentials without rejecting
significant rhythmic activity of cortical origin, the loss
introduced by the filter 14 rises abruptly above a frequency of
about 12 c/s. Below a frequency between 2 and 3 c/s loss also
increases to reduce the effects of interference originating from a
number of sources such as psycho-galvanic responses, sweating, and
electrode movement. A high degree of rejection is provided at
frequency of the power supply (e.g. 50 c/s in the U.K. as shown in
FIG. 6 or 60 c/s in the U.S.A.) to reduce the proportion of
amplified antiphase supply frequency components which can occur at
the input of the parametric amplifier 13 when connected to a
subject to whom other apparatus is attached.
Perhaps the most important part of the filter characteristic lies
between about 3 c/s and 13 c/s and has been devised following the
realization that the electrical activity of the brain can be
represented in a simplified form as shown in FIG. 2 for the
frequency range indicated where V.sub.E is the voltage between
electrodes fixed to the scalp. The random activity mentioned above
is represented by the line 40, and the rhythmic activity (that is
alpha rhythm) by lines 41, 42 and 43. Since it is random, the
random activity conveys no more information at any one frequency
than it does at any other. To get a good estimate of its level with
a high degree of confidence (a large number of degrees of freedom),
it is justifiable to weight the spectrum between about 3 c/s and 13
c/s as shown in FIG. 6 that is to have a decreasing loss with
frequency which rises at a rate of 7 db over a frequency range of 4
to 1. This rate of decrease substantially equalizes the amplitude
of signals, due to random electrical activity of the brain, at the
filter output, and the rate can be obtained from the change in
brain activity with frequency of FIG. 2. Fluctuation of high
frequency components now have the same degree of effect on the
output as do those at low-frequencies, as shown by the line 44 in
FIG. 3. The rate at which random activity varies depends to some
extent on the person considered and the 7 db rate mentioned above
gives a practical filter for general use and represents an average
rate. Individual variations are likely to be within - 3 db to + 5
db of the 7 db rate.
It is believed that the major component 43 of the rhythmic activity
usually occurs at about 10 cps. It this were to have a small
amplitude and the spectrum were not weighted, fluctuation of this
component would be swamped by fluctuations of the low frequency
random activity. However, by weighting the spectrum, fluctuations
of this component are more prominent - as shown at 45 in FIG. 3.
When this is added to the random activity, the width of the band
written out by the recorder, where the recorder is a slow speed
chart recorder, alters (because of the large amplitude fluctuations
of the rhythmic components), as does the amplitude distribution
within the band.
Therefore the lower edge of the band is expected to indicate the
lowest level usually reached by the random activity, assuming that
the rhythmic activity is not continuously present, while the upper
edge of the band indicates the highest level reached by the
rhythmic and/or random activity. The width of the band, its height
above the baseline, and the amplitude distribution within the band
indicate the type of activity in the signal. The rectified output
of random activity would tend to have a Rayleigh amplitude
distribution. However, by using a logarithmic amplitude scale, this
is converted to a more normal distribution, as well as giving
useful amplitude compression. For example, considering the output
from the chart recorder, if a component at about 4 c/s with a given
amplitude variance were to be compared with a 10 c/s component with
the same amplitude and variance, the width of the band drawn by the
chart recorder would be nearly the same in the two cases, but they
would be displaced by different amounts from the baseline, because
of the frequency loss characteristic of the filter. Conversely, if
both components formed part of the random activity where the 4 c/s
component would usually have a larger amplitude (see line 40 FIG.
2), the displacement for the two components and the width of the
band would be approximately the same.
The special characteristic of the filter 14 can be achieved in many
known ways, and one such way will now be described in detail.
The major part of the characteristic above about 3 c/s is
determined by a filter section 50 (see FIG. 9) of the type known as
an unbalanced twin "T" section. Such a filter section may be
designed in the way described in Electronic Engineering for Apr.
1967 at page 219 by W. Farrer in an article entitled "A Simple
Active Filter with Independent Control Over Pole and Zero
Locations," to have at first a balanced characteristic as shown at
51 in FIG. 10 with maximum rejection at a frequency of the power
supply. By successively adjusting potentiometers R5 and R9 the
section 50 becomes progressively unbalanced and has the
characteristics shown at 52 and 53. By measuring the characteristic
and adjusting the potentiometers R5 and R9 the required
characteristic above 3 c/s of FIG. 6 is obtained. A resistor R1 and
a capacitor C1 form a simple R-C low pass filter which provides
additional attenuation above 20 c/s.
Below 3 c/s the characteristic depends on a filter section 54 of
the type known as a Butterworth high pass filter. Such a filter may
be designed in the way described in the Burr Brown Handbook of
Operational Amplifier Active Networks at page 82. This handbook is
available from the Applications Engineering Section, Burr Brown
Research Corporation, International Airport Industrial Park,
Tuscon, Arizona.
The characteristic of FIG. 6 can be obtained with the component
values given in Table 1 where the designations refer to FIG. 9.
TABLE 1
Compon- Value Components Value or Type -ents
__________________________________________________________________________
R1 33 K.OMEGA. C1 0.22.mu. F R2 and 120 K.OMEGA. C2,C3 and C6
0.1.mu.F R3 R4 1 K.OMEGA. C4 and C5 0.5.mu.F R5 and up to 1
K.OMEGA. T1 and T4 2N 2484 R9 R6 and 22 K.OMEGA. T2 and T3 2S 304
R7 R8 11 K.OMEGA.
__________________________________________________________________________
instead of using a filter of the type shown in FIG. 9, the filter
14 may be designed according to the methods given by S.S. Haykin in
his book "Synthesis of R-C Active Filter Networks" published by
McGraw Hill, London 1969, see particularly Chapter 4.
Other ways are known in which filters with specific characteristics
can be designed and many of these ways are suitable for the design
of the filter 14.
The logarithmic amplifier 15 may comprise an operational amplifier
55 with two silicon diodes 56 and 57, for example type 1S44,
connected in its feedback path. To provide a smooth gain
characteristic for the amplifier 55 at very low voltages where the
diodes do not conduct a potentiometer R10 of maximum resistance 50
K.OMEGA. and a resistor R11 of resistance 100K.OMEGA. are connected
in parallel with the diodes. The amplifier 55 may be one of the
commercially obtainable operational amplifiers. The gain of the
amplifier 15 applies amplitude compression which is then
approximately proportional to the logarithm of the deviation of the
input signal from virtual earth at the non-inverting input terminal
of the operational amplifier.
Examples of two outputs obtained from the apparatus of FIG. 1 are
given in FIGS. 7 and 8. The recording electrodes 10 and 11 were
placed on the scalp of the subjects some two inches posterior to
the vertex and some 21/2 inches apart symmetrically disposed about
the mid-line. This electrode position was chosen because this is
the region in which the largest EEG activity is usually recorded
with a minimum of interference from muscle activity, and because it
records from both hemispheres simultaneously. A ground electrode,
which can be omitted if electrical isolation of the subject is
required, was placed on the subject's forehead.
FIG. 7 shows the output from a normal subject performing
mathematical calculations and drawing graphs. It can be seen that,
over the recorded period, the variation of amplitude remained
substantially constant, with occasional larger deflections
superimposed. In this case these larger deflections coincided with
bursts of alpha rhythms.
By comparison, FIG. 8 shows the output from a patient who had
survived a severe cardiac arrest. The electroencephalogram recorded
15 minutes prior to the start of this record had little discernible
activity apart from occasional large bursts of sinusoidal waves. It
can be seen that the general level of activity steadily declined,
to the point where a second cardiac arrest occurred. There followed
a brief period of high voltage activity during unsuccessful cardiac
massage.
In another case (not illustrated in the figures) a gradual rise in
the band of activity from the baseline was the first indication by
many hours of the recovery of an unconscious patient suffering from
an overdose of barbiturates. Had this indication not been available
resuscitation might have seemed hopeless and abandoned.
The usefulness of the write-out can be extended. If the large
spikes shown on the declining phase of FIG. 8 had occurred more
frequently, the output would have been simply a thick band of
activity. To avoid this possibility, an electro-sensitive or heat
sensitive write-out system can be used. In this case the write-out
can be arranged to have the greatest intensity at those levels most
frequently occurring where the pen of the recorder passes several
times over the same point on the recording medium giving an
amplitude distribution plot of the output by means of varying
shades of intensity. This enables different types of EEG activity
having different amplitude distribution to be recognized even
though they might have the same peak to peak range of
variation.
For some work it might prove desirable to have less low frequency
activity present in the output. This can be arranged by providing
variable sections to the filter which gives the low frequency
cut-off point at 2 c/s. By this means the operator can select the
appropriate low frequency cut-off point. A similar provision can be
made for the higher frequency cut-off point at 15 c/s.
Apparatus for monitoring the impedance of apparatus associated with
the electrodes 10 and 11 is shown in FIG. 4.
An oscillator 21 with a frequency which is well above the frequency
range of physiological activity of interest, and therefore outside
the passband of the filter 14, is applied across the electrodes 10
and 11 through series resistors R51 and R52 which are large
compared with the input impedance of the amplifier 13. A small
capacitor C19, the impedance of which is negligibly high at the
frequency of the physiological activity but not at the frequency of
the applied oscillations is connected across the input terminals of
the amplifier 13.
The source of signals being monitored is represented by a source
impedance 25 and an oscillator 26, the impedance 25 being partly
dependent on the conditions of contact between the skin and the
disc electrodes.
When the source impedance 25 is small compared with the impedance
of the capacitor C19 at the applied frequency, there will be little
phase difference between the output signals of the oscillator 21
and the voltage developed across the input terminals of the
amplifier 13, since both the capacitor C19 in parallel with the
impedance 25 and the complete oscillator load (including the
resistors R51 and R52, the capacitor C19 and the impedance 25) are
mainly resistive. However, if the impedance 25 increases so that it
becomes comparable with or greater than the impedance of the
capacitor C19, the impedance 25 and the capacitor C19 taken
together become more reactive and a phase lag up to a maximum of 90
degrees is produced at the amplifier input.
To prevent the monitoring voltage applied across the capacitor C19
from disappearing if the electrodes are short circuited, small
resistors R53 and R54 of negligible impedance compared to the input
impedance of the amplifier 13 are connected in series with the
electrode leads.
At the output of the amplifier 13 the signal from the oscillator 21
is separated from the signals from the source 26 by a frequency
selective amplifier 30 and formed into a square-wave by a clipping
amplifier 31. To compare the phase of the square-wave signal with
that of the output signals of the oscillator 21, the square-wave
signal is applied to an AND gate 32, together with signals from the
oscillator 21 which have been formed into a square-wave by a
clipping amplifier 33.
When signals across the capacitor C19 and at the output of the
oscillator 21 are in phase, signals arriving at the AND gate 32 by
the two paths are out of phase, due to an inversion arranged in one
path. Thus the AND gate is not open for in phase oscillator and
capacitor signals, but opens, for increasing periods, as the phase
difference increases. Consequently the magnitude of the signal from
a smoothing network 34 depends on the phase difference and hence on
the source impedance 25.
A recorder 35 gives a continuous record of the condition of the
electrodes and a trigger circuit 36 operates an alarm 37 when the
source impedance rises to an unacceptable level. The trigger
circuit 36 may be of any suitable known voltage sensitive type.
A further trigger circuit may be added so that if the impedance
falls below a given level, indicating an input short circuit,
another alarm circuit may be operated. This alarm circuit may be of
such a nature that the chart recorder pen is deflected from the
recording area, preventing the recording of inaccurate
information.
A further features of the impedance monitor is that it can be
arranged to give an indication if the signal from the oscillator 21
is prevented from passing from the amplifier 13 to the amplifiers
30 and 31 by blocking of the amplifier 13 or by circuit failure.
This is accompanied by adjusting the bias of clipping amplifier 31
so that, in the absence of an input from amplifier 30 the input to
the AND gate 32 switches to the "on" state. Under normal circuit
conditions, with a very low source resistance 25, the two inputs to
the gate 32 are 180.degree. out of phase and the gate does not
open. With a very large source resistance, the two inputs to the
gate are 90.degree. out of phase and the gate opens for one quarter
of a cycle. With no input to the amplifier 31 the gate is switched
solely to the clipping amplifier 33 an input from the amplifier 31
being present permanently, and is open for alternate half
cycles.
Therefore it can be seen that, if the output voltage from the
smoothing network 34 is zero for a very small source resistance 25
and is V for a very large source resistance then, if the input to
the clipping amplifier 31 is removed, the output becomes 2V. Other
output configurations can be achieved. For example, by including a
90.degree. phase shift in amplifier 30 the output from the
smoothing network 34 can be zero for large source resistance, V for
zero source resistance, and 2V for no input to amplifier 31.
While suitable circuits for the impedance monitor are well known, a
circuit diagram for the above described impedance monitoring
equipment including a 90.degree. phase shifter in the amplifier 30
is shown in FIG. 5.
A resistor R12 and a capacitor C7 in the amplifier 30 together with
the input impedance of a transistor T5 in parallel with the
resistors R13 and R15 form a high pass filter which attenuates
frequencies having a physiological origin but which permits the
impedance monitoring signal to pass with less attenuation. A
capacitor C11 and a resistor R25 with the input impedance of a
transistor T10 in parallel with the impedance of a biasing resistor
R28 have the same effect as do a capacitor C9, a resistor R17, the
input impedance of a transistor T6 in parallel with a resistor R20.
Thus signals of physiological origin are prevented from reaching
the clipping amplifier 31.
The resistors R53 and R54 and the capacitor C19 are used as part of
the R.F. trap 12. It is convenient to use a multi-vibrator as the
oscillator 21, although a square-wave source produces more
complicated phase changes across the capacitor C19 than a sine
wave. Performance is not much degraded but some phase adjustment
may be desirable at the output of the amplifier 13. Since the
multivibrator provides a square-wave the clipping amplifier 33 is
not required.
Two complementary outputs are taken from the multivibrator to drive
two subordinate AND gates made up of diodes D1 and D2, and D3 and
D4, respectively. The clipping amplifier 31 also acts as a phase
splitter with the collectors of transistors T10 and T11 driven in
antiphase. Thus the two subordinate AND gates operate in antiphase
and charge is supplied to capacitor 13 twice as frequently as would
otherwise occur and the amplitude of the output signal applied to a
buffer amplifier 38, provided to drive the recorder and the trigger
circuit, is doubled. The 90.degree. phase shift in the amplifier 30
is obtained at the junction of the capacitor C8 and the resistor
R17 which are driven from antiphase outputs at the collector and
emitter of the transistor T5.
Where it is required to indicate loss of the impedance monitoring
signal generated by the multivibrator 21, the diodes D3, D4 and D6
are omitted, thus one gate only is provided. Also a resistor (not
shown) is added between the base of the transistor T11 and the
terminal to which the - 8.5V bias is applied. This resistor is
individually selected to provide a suitable bias for the AND gate
when the monitoring signal is absent. The loss of the input signal
then causes the gate to be open for one half of each cycle, zero
impedance at the electrodes 10 and 11 opens the gate for a quarter
of each cycle and with high impedance the gate is closed during the
whole cycle. With such an arrangement the alarm circuit which
detects a short circuit input may also be used to detect loss of
the monitoring signal.
The circuit of FIG. 5 may be constructed using the components given
in TABLE II, where the designations used are those shown in FIG.
5.
TABLE II
Components Value Components Value or Type
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R14 R16 R38 1 K.OMEGA. C8 C11 C13 0.1 .xi.F R18 R19 R28 10 K.OMEGA.
C7 C14 C15 0.01 .mu.F R32 R42 R45 10 K.OMEGA. C9 0.047 .mu.F R20
R22 R33 R34 22 K.OMEGA. C12 C10 1 .mu.F R39 R47 22 K.OMEGA. C16 C17
0.005 .mu.F R12 R15 47 K.OMEGA. C19 0.001 .mu.F R21 R24 R25 2.2
K.OMEGA. C18 0.002 .mu.F R30 R31 2.7 K.OMEGA. T5 T6 T7 T13 2 N 3707
R53 R54 2.2 K.OMEGA. R41 R46 R49 R50 4.7 K.OMEGA. T10 T11 T9 T8 2 N
3703 R13 120 K.OMEGA. T12 2 S 304 R17 1.5 K.OMEGA. T14 T15 2 N 1304
R23 1 M.OMEGA. D1 D2 D3 0 A 91 R26 6.8 K.OMEGA. D4 D5 D6 0 A 91 R27
3.3 K.OMEGA. D7 D8 0 A 91 R29 680 .OMEGA. R37 330 K.OMEGA. R40 R48
56 K.OMEGA. R43 R44 82 K.OMEGA. R51 R52 70 M.OMEGA.
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the arrangement of FIGS. 4 and 5 is inherently insensitive to
changes of gain of the amplifier 13 and since the monitoring
voltages are alternating the electrodes are not polarized.
The impedance monitoring apparatus has been specifically described
for use with the signal-monitoring apparatus but it could of course
be used wherever the impedance associated with electrodes is
important.
It is expected that in addition to monitoring of EEG following
cardiac arrests the signal-monitoring apparatus will find a useful
application in monitoring EEG under long term anaesthesia, with
particular emphasis on open heart surgery where the maintenance of
a sufficient blood supply to the brain is of critical importance.
Apart from warning of imminent cortical extinction, the clear
representative of trends should prove to be more convenient than
retrospective visual comparisons of conventionally recorded
EEG.
A further intended application of the apparatus for monitoring EEG
is in studying the effect of drugs and the monitoring of long term
sleep changes under various conditions.
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