U.S. patent number 3,685,248 [Application Number 05/068,686] was granted by the patent office on 1972-08-22 for process for sterile filling of collyrium flasks and the like and apparatus for carrying out said process.
Invention is credited to Jozef Guido Godelaine.
United States Patent |
3,685,248 |
Godelaine |
August 22, 1972 |
**Please see images for:
( Certificate of Correction ) ** |
PROCESS FOR STERILE FILLING OF COLLYRIUM FLASKS AND THE LIKE AND
APPARATUS FOR CARRYING OUT SAID PROCESS
Abstract
A process for sterile filling of collyrium flasks and the like
wherein a flask, a stopper and a filter-holder are placed and
sterilized within a closed bag and manipulated from outside the bag
in the proper sequence to allow the filling of the flask and the
closure thereof prior to removing said flask from said bag.
Inventors: |
Godelaine; Jozef Guido (2610
Wilrijk, BE) |
Family
ID: |
3855623 |
Appl.
No.: |
05/068,686 |
Filed: |
September 1, 1970 |
Foreign Application Priority Data
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|
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Nov 10, 1969 [BE] |
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741,479 |
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Current U.S.
Class: |
53/425; 53/467;
141/1 |
Current CPC
Class: |
B65B
3/003 (20130101) |
Current International
Class: |
B21F
45/00 (20060101); B65B 3/00 (20060101); B21F
45/24 (20060101); B65b 001/04 (); B65b
003/04 () |
Field of
Search: |
;141/1,10,85,91,92,97,114,329,330,390,51,286
;21/1,2,56,58,78,91,DIG.4 ;53/37,282 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Bell, Jr.; Houston S.
Claims
What I claim is:
1. A process for sterile filling of collyrium flasks and the like,
characterized in that it comprises principally disposing the flask,
its stopper and a filter-holder with a bacteria filter in a
sterilization bag, closing said bag, sterilizing the bag with its
content and, after the sterilization, by manipulating the closed
bag from outside, namely by locally distorting it, bringing the
flask against the outlet opening of the filter-holder provided that
the latter has not been initially disposed on the flask, filling
the flask from outside the bag via a syringe and, by manipulating
from outside the bag, removing the filter-holder of the flask and
bringing the stopper on the latter and then opening the bag.
2. A process according to claim 1, characterized in that the said
bag is closed by clamping its open end around the filter-holder
with a bacteria filter, the inlet opening of said filter-holder
remaining thereby outside the bag.
3. A process according to claim 1, characterized in that the said
bag is normally closed whereby before or after the sterilization, a
clamping means is applied outside the bag and around the
filter-holder thereby forming two chambers in the bag so that one
of said chambers comprises the flask, the stopper and the outlet
portion of the filter-holder, whereas the second chamber, which
comprises the inlet portion of the filter-holder, is opened before
the injection.
Description
This invention relates to a process for sterile filling of
collyrium flasks and the like as well as to apparatuses for
carrying out said process. It is generally recognized and in
numerous countries, it is even mandatory to fill up collyrium
flasks in sterile conditions. The best method known heretofore to
practically meet this requirement comprises sterilizing the flask,
its stopper and a filter-holder with a bacteria filter in a
sterilization bag suitable therefor, whereupon these elements are
removed from the bag or bags to be manipulated with hand under
UV-irradiation or not. This direct handling presents a hazard of
smearing which cannot be completely excluded even with the said
UV-irradiation.
The object of this invention is to allow a simple preparation of
collyrium under quite sterile conditions.
For this purpose, there is suggested a process which comprises
principally disposing the flask, its stopper and a filter-holder
with a bacteria filter in a sterilization bag, closing said bag,
sterilizing the bag with its content and, after the sterilization,
by manipulating the closed bag from outside, namely by locally
distorting it, bringing the flask against the outlet opening of the
filter-holder provided that the latter has not been initially
disposed on the flask, filling the flask from outside the bag via a
syringe and, by manipulating from outside the bag, removing the
filter-holder of the flask and bringing the stopper on the latter
and then, opening the bag.
The said bag may be closed either by clamping its open end around
the filter-holder with bacteria filter so that the inlet opening of
the said filter-holder remains outside the bag, or normally in such
a way that, before or after the sterilization, a clamping means is
adapted outside the bag and around the filter-holder, thereby
forming two chambers in the bag, one of said chambers containing
the flask, the stopper and the outlet portion of the filter-holder,
whereas the second chamber which comprises the inlet portion of the
filter-holder, is opened before the injection.
By this way, the flask leaves the sterile bag or a sterile portion
thereof immediately after having been filled up and after having
been tightened with its drop-stopper. Then, it may be truly
question of a quite sterile filling.
In order to carry out said process more easily and more
particularly the said handlings, also in accordance with the
invention, use may be advantageously made of an apparatus
consisting at least of a holder for the flask, a holder for the
drop-stopper and a connecting means between said two holders, so
that relative turn over and/or translation movements between the
flask and the stopper may be induced by manipulation.
Some embodiments of such apparatus will be described hereafter with
more details by way of illustration and without any limitation,
reference being made to the enclosed drawings in which :
FIG. 1 is a front view of an apparatus according to the invention
in its two characteristic positions;
FIG. 2 shows another embodiment of an apparatus according to the
invention;
FIG. 3 shows a longitudinal section of a third embodiment according
to the invention;
FIG. 4 is a view taken according to arrow F4 of FIG. 2 and
FIG. 5 shows the apparatus according to FIGS. 3 and 4, immediately
before the preparation of a collyrium.
The apparatus according to FIG. 1 comprises principally a holder 1
for the flask 2, a holder 3 for the drop-stopper 4 and, between
said two holders, a connecting means 5. The latter is formed, on
one hand, by two upright diametral strips 6-7 fixed to the holder 1
and, on the other hand, by two profiled arms 8-9 fixed to holder 3,
whereby said strips 6-7 and arms 8-9 are pivotally connected to
each other near their ends by means of rivets 10 and 11
respectively. Near their free ends, the said both arms 8-9 have a
bent edge portion 12-13 respectively bearing agents the edges of
the strips 6 and 7 when the holders 1 and 3 are disposed
coaxially.
The two extreme positions of said apparatus are shown respectively
on the left hand and on the right hand of FIG. 1.
In the embodiment according to FIG. 2, the connecting means 5
consists of an L-shaped plate 14 in which are provided two slots 15
and 16 at right angles to each other. Two sliders 17 and 18
respectively may be shifted along said slots. The flask-holder 1,
under the form of a resilient clamp may be fastened on slider 17,
whereas two similar clamps fastened on slider 18 are forming the
drop-stopper holder 3.
On plate 14 and at one end of slot 15, is fixed a small bracket 19
with a ring 20. Around said ring 20, may be shifted the outlet side
of a filter-holder 21 known per se, the latter being disposed
coaxially with holder 1.
In the embodiment shown in FIGS. 3-5, the connecting means 5 is
formed by a U-shaped plate 22 with a long leg 23 and a short leg
24, the latter being connected to each other through a cross-piece
25.
On leg 23, is fastened the flask-holder 1 under the form of a
resilient clamp.
Practically, with collyrium flasks, a drop-stopper consists of a
dropper 4a which may be screwed on the neck of the flask, and of a
stopper proper 4b. When using the described apparatus, the dropper
4a is permanently mounted upon flask 2.
In that case, the stoppper-holder 3 consists of a firstly conical
and then cylindrical bore passing through the cross-piece 25 and in
which the stopper 4b is pushed. The stopper may be tightened in
this pushed position by means of a screw 26.
Under the stopper-holder 3, the cross-piece 25 has a bore 27 in
which the end of the dropper 4a may be pushed.
The free end of leg 24 has two diverging guide flanges 28 and 29
bent in the direction of leg 23. In addition, the plate 22 is
provided with a bore and a bearing piece 30-31 respectively so that
an outlet needle 32 of the filter-holder 21 projects also through
said bore 27.
When carrying out the process according to the invention by means
of any of the above described apparatuses, the flask 2 and the
stopper 4 (4b) are firstly fitted in holders 1 and 3 respectively.
The filter-holder 21 loaded with a bacteria filter 33 remains
either disengaged from the apparatus (FIG. 1) or is mounted on the
apparatus (FIGS. 2, 3, 5).
The apparatus and the filter are then pushed in a sterilization bag
34 known per se, said bag being then closed. Before or after the
sterilization, the bag is adapted around the filter-holder 21, e.g.
by means of a resilient ring 35, thereby forming two chambers 36-37
respectively in the bag. Chamber 36 comprises the loaded apparatus
and the outlet end of the filter-holder 21, whereas chamber 37
comprises only the inlet end of the filter-holder.
After the sterilization, chamber 37 is opened by cutting or tearing
the bag.
By manipulating the bag from outside, the flask is brought against
the outlet opening of the filter-holder by shifting either the
whole apparatus (FIG. 1, right position) or the slider 17 (FIG. 2)
towards the filter-holder. Of course, the above mentioned opening
of chamber 37 could just occur at that point.
With the apparatus according to FIGS. 3-5, this shifting of the
flask towards the filter-holder is not necessary.
Then, the flask may be filled up with liquid via the filter-holder
and the filter by means of a syringe.
The flask is then removed from the filter-holder (by shifting the
whole apparatus (FIG. 1), by shifting the slider 17 (FIG. 2) or by
axially shifting the flask (FIGS. 3-5).
The flask and the stopper are then almost coaxially disposed by
pivoting the connecting means 5 (FIG. 1) or by shifting the slider
18 (FIG. 2) or by tilting the flask (FIGS. 3-5). The flask is then
shifted towards the stopper and screwed therein.
All these handlings have been thus carried out within the still
closed sterile chamber 36. The latter may be then closed.
The above mentioned sterilization may of course be carried out with
dry heat, steam, radiation and sterilizing gases.
Of course, as regards the apparatus, the invention is not limited
to the above described embodiments. For instance, it could be
possible to modify the apparatus according to FIGS. 3-5 so that the
flask and the stopper are kept normally and substantially coaxial,
the needle 32 being thereby resiliently distorted to penetrate the
dropper.
The described apparatuses may be also adapted in accordance with
the nature and the shape of the used drop-stoppers.
This invention covers also an equipment considered as a new
industrial product and consisting of at least a sterilization bag,
an apparatus of the above described type and a clamping means
intended to divide the said bag into two chambers.
* * * * *