U.S. patent number 3,666,955 [Application Number 05/053,211] was granted by the patent office on 1972-05-30 for automatic control system for radioactive regional ventilation studies.
Invention is credited to Clayton H. Douglas, Harold F. Rieth, Edgar L. Suprenant.
United States Patent |
3,666,955 |
Suprenant , et al. |
May 30, 1972 |
AUTOMATIC CONTROL SYSTEM FOR RADIOACTIVE REGIONAL VENTILATION
STUDIES
Abstract
A system for obtaining a permanent visual record of the air
passages of the lungs by the introduction of a measured quantity of
air mixed with a radioactive gas such as Xenon (Xe.sup.133) into
the lungs of the subject. A conventional scintillation camera or
other radioactive recording device is operated to produce a
permanent visual record. A separate air reservoir provides
non-tagged air to fill the breathing passages and confine the
radioactive tagged air to the lungs. The apparatus operates in
sequence to supply the desired quantity of radioactive tagged air
from a reservoir, followed by the measured quantity of ordinary air
from a second reservoir, and then prevents exhalation during the
time period necessary for the radioactive recording device to
operate. The supply of premeasured quantities of tagged air and
additional air insure that the subject will take only a normal size
breath. Ganged stepping switches and a timing device provide
automatic sequencing. A modified form of the apparatus utilizes a
flexible wall radioactive gas reservoir and an associated pivoted
lever which drops down to actuate a microswitch and open the valve
to the additional air when the radioactive gas reservoir is
depleted. A method is described in which measured quantities of
tagged air and additional air are sequentially applied to the
subject, exhalation is prevented during the period in which the
radioactive recording is made, and exhalation is thereafter
permitted.
Inventors: |
Suprenant; Edgar L. (Encino,
CA), Rieth; Harold F. (Costa Mesa, CA), Douglas; Clayton
H. (Palos Verdes, CA) |
Family
ID: |
21982662 |
Appl.
No.: |
05/053,211 |
Filed: |
July 8, 1970 |
Current U.S.
Class: |
424/1.11;
250/303; 128/200.26; 128/203.14; 128/203.29; 250/493.1 |
Current CPC
Class: |
A61B
5/0813 (20130101) |
Current International
Class: |
A61B
5/08 (20060101); G01t 001/20 () |
Field of
Search: |
;250/16T,71.5S ;128/2.8X
;424/1 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Lawrence; James W.
Assistant Examiner: Frome; Morton J.
Claims
We claim:
1. An automatic control system for radioactive regional ventilation
studies, comprising
a breathing device adapted for sealed communication with the
breathing passages of a living subject,
a control valve means for said breathing device having inlet and
outlet passages and being responsive to the breathing of the
subject to permit inhalation by the subject only from said inlet
passage and exhalation only through said outlet passage,
a radioactive gas reservoir capable of holding a measured volume of
gas at ambient pressure,
a gas supply valve connecting said inlet passage of said control
valve means to said radioactive gas reservoir,
an air supply reservoir capable of holding a measured volume of air
at ambient pressure,
an air supply valve connecting said inlet passage of said control
valve means to said air supply reservoir,
an ambient air supply valve connecting said inlet passage of said
control valve means to ambient air,
an exhaust conduit,
an exhaust valve connecting said outlet passage of said control
valve means to said exhaust conduit,
and actuating means operatively connected to said valves and formed
for opening and closing said valves in a desired sequence.
2. An automatic control system as described in claim 1, and wherein
said actuating means further comprises an actuating mechanism for a
radioactive recording device, with said actuating mechanism being
operated at desired places in said sequence.
3. An automatic control system as described in claim 1, and wherein
said actuating means is formed to cycle automatically through said
sequence.
4. An automatic control system as described in claim 1, and wherein
said actuating means further comprises solenoid actuators for each
of said valves, and switch means formed to provide electrical
current to said solenoid actuators in said desired sequence.
5. An automatic control system as described in claim 4, and wherein
said switch means includes a stepping switch, and a timing device
for cycling said stepping switch through said desired sequence in
desired increments of time.
6. An automatic control system as described in claim 1, and wherein
said air supply valve is responsive to depletion of said
radioactive gas reservoir.
7. An automatic control system as described in claim 6, and wherein
said radioactive gas reservoir comprises a flexible wall bag, a
pivoted arm rests on said bag and is formed to drop through an arc
as radioactive gas is removed from said bag, said air supply valve
is electrically operated, and a switch device is positioned to
intercept said arm and supply electrical current to said air supply
valve so as to open the latter when said arm drops a desired
distance.
8. A method of conducting radioactive regional ventilation studies,
comprising the steps of
excluding ambient air from the breathing passages of a subject,
supplying a measured quantity of radioactive tagged air equivalent
to the increase in normal volumetric capacity of the subject's
lungs during normal breath of the subject, said radioactive tagged
air being delivered at ambient air pressure to the breathing
passages of the subject for inhalation into the lungs,
supplying an measured quantity of additional air to said breathing
passages equivalent to the tidal volume thereof so as to
concentrate said radioactive tagged air in the lungs,
preventing exhalation of said measured quantities of radioactive
tagged air and additional air for a period of timed duration,
making a visual record of the lungs by radioactive recording during
said period of timed duration,
and permitting exhalation of said measured quantities of
radioactive tagged air and additional air at the end of said
period.
9. A method of conducting radioactive regional ventilation studies
as described in claim 8, and which comprises the additional steps
of venting the exhaled radioactive tagged air to the outside.
Description
BACKGROUND OF THE INVENTION
This invention relates to an Automatic Control System For
Radioactive Regional Ventilation Studies, and more particularly to
a method and apparatus to facilitate the making of a permanent
visual record of the air passages of the lungs with a scintillation
camera or other radioactive recording device responsive to
radioactive emissions from a quantity of radioactive tagged gas
breathed into the lungs by the subject.
Radioactive ventilation studies have proven to be valuable as a
diagnostic tool. However, a number of problems have been
encountered in the techniques used heretofore. A major problem
results from the necessity of performing a number of mechanical
operations in the proper sequence in less than a minute.
The proper quantity of radioactive tagged gas must be supplied to
the lungs of the subject, and an additional quantity of air
representing the tidal capacity of the subject's breathing passages
should be placed in such passages, the breath must be held during
the period of time necessary for the radioactive recording device
to operate, and the exhaled radioactive tagged gas must be removed.
Provision must be made to seal the system against escape of the
radioactive gas, and the study must be made as comfortable as
possible for the subject, who may be in poor physical
condition.
SUMMARY OF THE INVENTION
The automatic control system of the present invention includes
provisions for overcoming the recited difficulties by automatic
sequencing of the procedures in a manner providing consistent and
reproducable results. In order to simplify the operation, the
complete procedure is operated from a compact control box, and
preferably can be automatically programmed to cycle through the
desired sequence.
It is important that, during the radioactive regional ventilation
study, the patient take only a truly normal breath. A larger than
normal intake expands the lung passages and the resulting
scintiphoto thus indicates a false lung condition. Likewise, a
smaller than normal intake produces an inaccurate indication of the
lung condition of the patient. It is also advantageous to maintain
the lung area in the normal size because of the normally limited
camera coverage area available.
It is also an advantage during the radioactive regional ventilation
study to concentrate the radioactive gas and restrict it solely to
the lungs. In the present invention, this is accomplished by
limiting the measured radioactive gas volume to the volumetric
capacity of the lungs during a normal breath, and thereafter adding
a measured quantity of normal air equivalent to the volumetric
capacity of the breathing passages leading from the mouth to the
lungs.
The present apparatus is capable of sequential operation either
manually or by automatic cycling. In either case, the controls are
interlocked to assure the desired sequence of operation.
Accordingly, it is an object of the present invention to provide an
apparatus for conducting radioactive regional ventilation studies
in which a measured quantity of radioactive tagged gas is supplied
to the lungs of the subject in a manner simulating normal breathing
action.
Another object of the present invention is to provide an apparatus
of the character described in which the radioactive tagged gas is
confined to the lung area by filling the breathing passages from
mouth to lung with a measured quantity of normal air.
A further object of the invention is to provide an apparatus of the
character described in which exhalation is prevented during the
time necessary to operate a radioactive recording device.
A still further object of the invention is to provide an apparatus
of the character described which operates automatically in a
desired timed sequence.
Yet another object of the present invention is to provide a method
of conducting radioactive regional ventilation studies in which
measured quantities of radioactive tagged air and normal air are
sequentially supplied to the lungs and breathing passages of the
subject at ambient pressures and in a manner closely approximating
a normal breath, with exhalation of same being prevented during
operation of a radioactive recording device.
Other objects and features of advantage will become apparent from
the following specification and the attached drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
The preferred forms of the invention are illustrated in the
accompanying drawings forming part of this specification, in
which:
FIG. 1 is a schematic view of an automatic control system for
radioactive regional ventilation studies constructed in accordance
with the present invention;
FIG. 2 is a fragmentary enlarged plan view of a portion of the
apparatus of FIG. 1;
FIG. 3 is an electrical circuit diagram illustrating a sequential
stepping switch arrangement forming part of the present invention;
and
FIG. 4 is a perspective view of a control device constructed in
accordance with the present invention, said control device being
responsive to depletion of a radioactive gas reservoir
While only the preferred forms of the invention have been
illustrated in the drawings, it will be apparent that other
modifications and changes could be made within the purview of the
attached claims.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
Referring to the drawings in detail, it will be seen that the
automatic control system of the present invention, basically
includes a breathing device or mask 11 adapted for sealed
communication with the breathing passages 12 of a living subject
13, control valve means 14 having inlet and outlet passages 16 and
17, the control valve means 14 being formed to permit inhalation by
the subject 13 only from the inlet passage 16 and exhalation only
through the outlet passage 17, a radioactive gas reservoir 18
capable of holding a measured volume of gas at ambient pressure, a
gas supply valve 19 connecting said inlet passage 16 to the
reservoir 18, an air supply reservoir 21 capable of holding a
measured volume of air at ambient pressure, an air supply valve 22
connecting inlet passage 16 to reservoir 21, an ambient air supply
valve 23 connecting inlet passage 16 to ambient air, an exhaust
valve 26 connecting outlet passage 17 to conduit 24, and actuating
means 27 operatively connected to the recited valves and formed for
opening and closing these valves in a desired sequence.
The control valve means 14 is shown schematically in FIG. 2 as
including check valves 28, 29 and 31 in the passages leading to the
mask 11 from valves 19, 23 and 26, respectively. In FIG. 2, check
valves 28 and 29 permit air from reservoirs 18 and 21, and ambient
air to enter mask 11 through inlet passage 16, provided the
associated valves 19, 22 or 23 are open, but prevent reverse flow
of air or gas. Likewise, check valve 31 permits exhaled air to flow
from mask 11 through outlet passage 17, provided valve 26 is open.
Any suitable valve means which will permit inhalation from the
inlet passage 16 and restrict exhalation to the outlet passage 17
could be used. A commercial valve of this nature is manufactured by
W.E. Collins Co. and is identified by the part No. P-320.
Valve 19 is here connected through "Y" tubing to the reservoir 18
of radioactive tagged air through a check valve 32. The capacity of
reservoir 18 is chosen to approximate the amount of air normally
inhaled into the lungs of the subject during a normal breath
(usually about 300cc). Valve 32 permits the radioactive tagged air
to be removed from the reservoir 18, but prevents entry into
reservoir 18 of the non-radioactive air from reservoir 23.
Reservoir 21 contains an additional volume of non-radioactive air
approximating the volume of the breathing passages of the subject
between the mouth and the lungs (usually about 150cc).
Valves 19, 22, 23 and 26 are preferably provided with actuating
devices which may be remotely controlled. Should manual operation
be desired, it may be accomplished by solenoids or air actuators,
controlled by a series of interlocking push-buttons, or individual
switches, or air valves. A table listing the several switch
positions and the resulting open or closed state of the valves, is
as follows:
Xe Switch Ambient Gas In Air Air Scint. Position Air in (Valve
exhaust reservoir Camera (Valve 19) (Valve (Valve 23) 26) 22)
__________________________________________________________________________
1 Open Closed Open Closed Off 2 Closed Open Open Closed Off 3
Closed Open Closed Open On 4 Closed Closed Closed Closed On 5 Open
Closed Open Closed Off
__________________________________________________________________________
The operator initiates the cycle by turning switch handle 41 on the
control box 42 to position 1 which opens valves 23 and 26, allowing
the subject to breath in ambient air through valve 23 and inlet
passage 16, and to breath out through outlet passage 17 and exhaust
valve 26, the exhaled air passing through a tube 43 to the exterior
of the building.
During an exhalation, the operator moves switch handle 41 to
position 2, closing ambient air supply valve 23 and opening
radioactive gas supply valve 19 so that the next inhalation will
draw the radioactive gas from reservoir 18.
At the instant the radioactive gas reservoir 18 is empty, the
operator moves the switch handle 41 to position 3 which opens valve
22 to supply the additional volume of non-radioactive air from
reservoir 21. Position 3 also closes the exhaust valve 26 and at
the same instant supplies electrical energy to close a relay 43
which starts the scintillation camera or other radioactive
recording device 44. The scintillation camera 44 requires
approximately 5 seconds to register the 15,000 counts necessary for
the print. The operator moves switch handle 41 to position 4 to
close valve 19 and, inasmuch as the valves 23 and 26 are already
closed, the subject is unable to exhale or inhale further.
At the expiration of the approximately 5 second time-count
interval, the scintillation camera 44 automatically shuts off and
the operator moves switch handle 41 to position 5, opening ambient
air supply valve 23 and air exhaust valve 26 so the subject can
resume normal breathing. Thus, switch settings 1 and 5 represent
the same set of conditions.
Additional scintiphotos can be obtained at various time intervals
following the initial tests, and under various conditions as
selected by the operator, if so desired. Such additional tests can
be automatically timed and programmed into stepping switch 38.
Where a completely automatic sequence is desired, stepping switch
38 is driven by timer 39, and the entire cycle is initiated by
closing switch 46. Obviously, the timer 39 should be adjusted to
permit sufficient time at each of the switch positions for the
intended function to take place.
A modified form of the invention is illustrated in FIG. 4 wherein
valve 22 is opened automatically as soon as the contents of the
radioactive gas reservoir are exhausted. The reservoirs 18a and
21a, corresponding to reservoirs 18 and 21 in FIG. 1, are provided
in the form of inflatable, flexible walled bags, such as rubber
bags. Reservoir 18a is supported on a platform 51, to which a
swingable arm 52 is pivoted to overlie and rest upon reservoir 18a
so that arm 52 swings upwardly as bag 18a is inflated and swings
downwardly as bag 18a is deflated. Arm 52 is in the position shown
in solid lines at the beginning of the cycle when reservoir 18a is
inflated. As the subject exhausts the contents of reservoir 18a,
the arm 52 drops under its own weight to the position shown in
dotted lines where the distal end of arm 52 actuates a microswitch
53 to supply electrical current to open solenoid valve 22 and allow
the normal air contents of reservoir 21a to be supplied to the
subject.
From the foregoing it will be apparent that the automatic control
system for radioactive regional ventilation studies of the present
invention provides a novel method of conducting such studies and a
novel apparatus capable of manual or automatic use.
* * * * *