U.S. patent number 3,660,241 [Application Number 05/002,231] was granted by the patent office on 1972-05-02 for container for organ perfusion or the like.
This patent grant is currently assigned to Baxter Laboratories Inc.. Invention is credited to Paul Joseph Michielsen.
United States Patent |
3,660,241 |
Michielsen |
May 2, 1972 |
CONTAINER FOR ORGAN PERFUSION OR THE LIKE
Abstract
A container having at least one access port defined therein; and
a flexible conduit passing through the access port in sealing
relation, in which the conduit is slideable relative to the port
without disruption of the seal.
Inventors: |
Michielsen; Paul Joseph
(Herent, BE) |
Assignee: |
Baxter Laboratories Inc.
(Morton Grove, IL)
|
Family
ID: |
21699815 |
Appl.
No.: |
05/002,231 |
Filed: |
January 12, 1970 |
Current U.S.
Class: |
435/284.1;
222/522 |
Current CPC
Class: |
A01N
1/0205 (20130101); A01N 1/02 (20130101) |
Current International
Class: |
A01N
1/02 (20060101); C12k 009/00 () |
Field of
Search: |
;195/127 ;128/DIG.3
;23/258.5 ;150/1 ;222/211,478,522,523 |
References Cited
[Referenced By]
U.S. Patent Documents
Other References
Eiseman et al., A Disposable Liver Perfusion Chamber, 60 Surgery,
No. 6, pp. 1183-1186.
|
Primary Examiner: Monacell; A. Louis
Assistant Examiner: Andewelt; Roger B.
Claims
I claim:
1. A container having an outer casing with a plurality of access
ports and a mouth opening defined therein, said mouth opening being
spaced from said access ports, a flexible conduit passing through
each said access port having a cross sectional shape generally
conforming to the shape of said access port and being of at least
equal transverse dimension to said port to provide a seal between
said container and conduit at the port, whereby said conduit is
slidable relative said port without disruption of said seal.
2. The container of claim 1 in which each said conduit is of such
length as to be able to extend through both said port and said
mouth opening at one sliding position of said conduit.
3. The container of claim 1 which said outer casing is made of
flexible material.
4. The container of claim 1 which said casing is rigid and
self-supporting.
5. The container of claim 1 comprising a pair of flexible,
transparent plastic sheets sealed together at the edges to define a
bag, said access ports being defined by tubular plastic sleeves
mounted between said plastic sheets at edges thereof.
6. The container of claim 9 in which a portion of the edges of said
plastic sheets are in unsealed relation to define said mouth
opening.
Description
BACKGROUND OF THE INVENTION
This application relates to a container having tubing leading into
the interior through a sealing port, which is useful as an organ
container for perfusion techniques.
The science of organ perfusion has been rapidly increasing in
importance in recent years because of the increase in organ
transplantation as a medical procedure. Basically, in organ
perfusion an organ such as a kidney, liver, lung, or heart is
removed from a donor and maintained in viable condition by
artificial means. This is done to maintain the organ until the
recipient is selected and prepared to receive it. At the present
time, organs of potential donors have sometimes been unavailable to
recipients in desperate need of them, because the donor, who is
often a victim of a fatal accident or illness, is located at a
region remote from the recipient. In this case, emergency measures,
such as maintaining the vital functions of a clinically dead donor
by elaborate artificial means, must be performed while transporting
the donor and the required life maintenance equipment to the
location of the recipient. This is frequently impossible to do.
The technique of organ perfusion is intended to simplify the
problem of storing and transporting living organs by providing a
generally portable artificial environment in which the organ can
survive until the time of implantation.
The organ, once severed from a donor, is generally cannulated to
connect it to a source of circulatory fluid which carries oxygen
and optional nutrients. The cannulation process generally takes
substantial manual dexterity, and it is desirable to perform the
operation in a relatively large space unhindered by the walls of an
organ perfusion container. However, the cannulated organ must then
be placed in the container, and it is undesirable to have
extraneous loops of cannula tubing coiling around the organ within
the container.
DESCRIPTION OF THE INVENTION
In accordance with this invention, a container is provided having
at least one access port defined therein which is spaced from a
mount opening in the container. Flexible conduit tubing passes
through the access port, the conduit tubing having a
cross-sectional shape generally conforming to the shape of the
access port, and being of at least equal transverse dimension to
the port to provide a pressure seal between the container and
conduit at the port. Thus, the conduit tubing is slideable relative
to the port without disruption of the seal to permit leakage and
interior contamination. Typically, the conduit tubing is long
enough to be able to pass through both the access port and the
mouth of the container in one sliding position of the conduit. Thus
an organ such as a heart, liver, lung, or kidney can be cannulated
outside of the container, and then placed within the container,
drawing excess tubing through the port out of the container.
The container of this invention can be rigid and self supporting,
or it can be a flexible, collapsible bag, or any other
configuration as desired.
Referring to the drawings:
FIG. 1 is a plan view of a flexible, collapsible bag made in
accordance with this invention, showing a cannulated organ
connected to some of the conduits of the bag.
FIG. 2 is a plan view of the same bag as in FIG. 1, showing how the
organ is placed within the bag and the conduits drawn through the
access ports out of the bag.
FIG. 3 is a sectional view taken along line 3--3 of FIG. 1, showing
details of the structure of the access port.
FIG. 4 is a sectional view taken along line 4--4 of FIG. 3.
FIG. 5 is an elevational view of another modification of a rigid,
self-supporting container of this invention.
FIG. 6 is a view of the closed container of FIG. 5.
Referring to FIGS. 1 through 4, flexible bag 10 is shown being used
as an organ perfusion container for a human kidney 12. Bag 10
comprises a pair of flexible, transparent plastic sheets 14, 16
sealed together at the edges by seal line 18 and rivets 19, or by
any other conventional means, to define a bag. In FIG. 1, sheet 14
is partly broken away to show sheet 16 behind it. A portion 20 of
the edges are left unsealed to define a mouth opening in the
bag.
Conduits 22, 24, 26, 28, and 30 are sealingly slideable, each in a
separate semi-rigid plastic sleeve 32. The sleeves 32 are sealingly
mounted between plastic sheets 14 and 16 to provide access ports
into the bag 10. Conduits 22, 24, 26, 28, and 30 are made of a
flexible material such as silicone rubber, and have a
cross-sectional shape generally conforming to the shape of the
sleeves or access ports 32, which are typically cylindrical. The
above mentioned conduits are typically of slightly larger size than
the ports 32 to provide a pressure seal between the bag and
conduits at the port. Thus conduits 22, 24, 26, 28, and 30 are
sealingly slideable within sleeves 32 when pulled on one end or the
other so that the length of each conduit within the bag is
adjustable.
In the embodiment shown, conduit 24 is cannulated to the renal
artery of kidney 12 to provide blood or other perfusate to the
kidney during perfusion. Conduit 28 is attached to the renal vein
of kidney 12 to receive the same fluid upon circulation through the
kidney and to carry it away from the kidney to conventional organ
perfusion equipment, which provides the necessary functions of
pumping the fluid and oxygenating it. Conduit 30 is cannulated to
the ureter of kidney 12 to receive and carry away waste products
formed therein. Conduits 22 and 26 are not used in this instance
and carry caps 23 and 27. These conduits are made available to
permit use of the bag with other organs or in the case of
bifurcations of the renal artery and vein.
After cannulation of the kidney with the aforementioned conduits,
the kidney 12 is placed within bag 10 and the mouth opening is
sealed by folding over and clamping or any other manner as desired.
Simultaneously therewith, the cannulated conduits are pulled by
their outer ends to cause each of them to slide through their
associated sleeve 32 to reduce the length of each conduit residing
within bag 10 so as not to crowd the kidney or to cause twisting of
the cannulation sites at which each conduit is connected to the
kidney.
Conduits 34, 36, and 38 serve as inlet and outlet conduits for
providing wash or perfusion solution to bathe the inside of the bag
and the outside of the organ. If desired, one can bathe the kidney
in an oxygenated, nutrient-containing isotonic solution through
conduits 34 and 36, which is withdrawn through conduit 38.
Throughout the period of kidney storage in bag 10, blood or other
perfusion solution is pumped to and from the kidney 12 through
conduits 24 and 28.
If desired, only one sliding conduit is connected to the kidney at
the renal artery, the renal vein and the ureter being allowed to
spill into the bag. Perfusion solution is then withdrawn from the
bag by a conventional conduit, e.g. conduit 38.
The entire bag 10 can be placed in an outer cooling bath to control
the temperature of kidney 12 and the perfusion solution. By the use
of this bag, great convenience is achieved in cannulating the
kidney to connect it to the appropriate conduits prior to placing
it into the bag. Then the kidney can be inserted in the bag and
sealed in a relatively sterile environment to maintain it in a
viable condition by perfusion of oxygenating solution which
optionally contains nutrient.
Referring to FIGS. 5 and 6, a self supporting organ perfusion
container made of acrylic plastic or the like is shown as including
a cylindrical bowl 40 having an open top 41, four sliding conduits
42, 43, 44, and 45, each of which slides through an access port
comprising a sleeve 46 to gain entrance to the container. As in the
previous embodiment, conduits 42 to 45 have a cross-sectional shape
conforming to the shape of each access port or sleeve 46, and are
of equal or slightly greater cross-sectional size to ports 46 to
provide a sliding pressure seal between the container 40 and the
conduits. Thus the conduits are slideable relative to the access
ports without disruption of the seal, thus preventing leakage out
of the container. Conduits 42 to 45 are of such length that they
can extend out of the top opening of bowl 40 for cannulation to an
organ such as a liver 48 (the conduits connecting, for example, to
one artery, two veins, and the bile duct). After cannulation is
complete, the conduits are withdrawn into the container by sliding
them through their respective sleeves 46, and the organ is
simultaneously placed into the container. The mouth opening 41 of
the bowl 40 can then be sealed or capped in any manner desired,
such as by sealing top 50.
The bowl 40 can be drained from bottom drain 51 as desired. A
conduit for flushing the outside of the organ can also be added, if
desired.
The containers of this application are thus suited for the
convenient cannulation and perfusion of a number of different
organs, to maintain the organs in viable condition outside of a
living body.
The previous disclosure is for illustrative purposes only and is
not to be taken as limiting the scope of the invention of this
application. It is to be understood that the arrangement and the
numbers of conduits connected to the containers of this invention
can be varied as desired in accordance with the objective to be
obtained.
* * * * *